1 Single cell expression data

Source:
High-throughput single-cell functional elucidation of neurodevelopmental disease-associated genes reveals convergent mechanisms altering neuronal differentiation, GEO accession: GSE142078.

Perturbations:
CRISPR knock-down of 14 autism spectrum disorder (ASD)–associated genes (3 gRNAs per gene) + 5 non-targeting gRNAs.

Cells:
Lund human mesencephalic (LUHMES) neural progenitor cell line.
Cells from 3 batches were merged together into 1 analysis. All cells have only a single type of gRNA readout. Quality control resulted in 8708 cells.

Genes:
Top 6000 genes ranked by the multinomial deviance statistics were kept.

Normalization:
Deviance residual transformation.
Batch effect, unique UMI count, library size, and mitochondria percentage were all corrected for. The corrected and scaled expression data were used as input for subsequent factor analysis.

Here, our "guide", \(G\) matrix, consists of 15 types (14 genes + NTC) of gene-level knock-down conditions across cells.

In each case, Gibbs sampling was conducted for 3000 iterations, and the posterior mean estimates were averaged over the last 1000 iterations. SVD Initialization.

1.1 Monocle Pseudotime Trajectory

We attempted to reproduce the pseudotime trajectory of cells as reported in the original paper.

1.2 Marker Gene Expression in Pseudotime

Neuronal markers (MAP2 and DCX) increase along the pseudotime trajectory, whereas progenitor markers (TP53 and CDK4) decrease, consistent with Fig 3B of original paper.

Neuron progenitor (NPC): TP53, CDK4, NEUROD1, NES?
Post-mitotic neuron: MAP2, DCX, STMN2

Glutamatergic neuron (excitatory): SLC17A6
Cortical neuron: BRN2 (POU3F2)
Developing striatal neurons: EBF1
Subtypes of inhibitory neurons: SST
Subtypes of extitatory neurons: NEFM

We separate the cells into 2 groups:

Early stage: 2523 cells in pseudotime state 1 - 3;
Late stage: 6185 cells in pseudotime satte 4 - 9.

We modified GSFA so that the associations (\(\beta\)) between factors and perturbations are estimated for early and late stage cells separately.

2 Factor ~ Perturbation Association

2.1 Early stage cells

2.2 Late stage cells

2.3 Correlation within Factors

2.3.1 Correlation with factors inferred using all cells

3 Factor Interpretation

3.1 Factor by gene loading

Cell differentiation markers and neuronal cell type markers:

protein_name	gene_name	type
TP53	TP53	Cell proliferation
CDK4	CDK4	Cell proliferation
Nestin	NES	NPC
Doublecortin	DCX	Post-mitotic neuron
STMN2	STMN2	Post-mitotic neuron
MAP2	MAP2	Post-mitotic neuron
DPYSL3	DPYSL3	Mature neuron
HSPA5	HSPA5	Mature neuron
MAP1B	MAP1B	Mature neuron
CRMP1	CRMP1	Mature neuron
CRABP2	CRABP2	Mature neuron
MAPT	MAPT	Mature neuron
NEFL	NEFL	Mature neuron
MEF2C	MEF2C	Mature neuron
ZEB2	ZEB2	Mature neuron
ITM2C	ITM2C	Negative regulation of neuron projection
CNTN2	CNTN2	Negative regulation of neuron projection
SERPINF1	SERPINF1	Negative regulation of neuron projection
Neurofilament-M	NEFM	Excitatory neuron
VGLUT2	SLC17A6	Excitatory neuron
Somatostatin	SST	Inhibitory neuron
EBF1	EBF1	Developing striatal neuron

3.2 Selected factor GO enrichment

4 DEG Interpretation

4.1 Number of DEGs detected under different methods

4.1.1 Early stage cells

Number of genes that passed GSFA LFSR < 0.05 under each perturbation:

4.1.2 Late stage cells

Number of genes that passed GSFA LFSR < 0.05 under each perturbation:

4.2 Perturbation effect on gene markers

Cell differentiation markers and neuronal cell type markers:

protein_name	gene_name	type
TP53	TP53	Cell proliferation
CDK4	CDK4	Cell proliferation
Nestin	NES	NPC
Doublecortin	DCX	Post-mitotic neuron
STMN2	STMN2	Post-mitotic neuron
MAP2	MAP2	Post-mitotic neuron
DPYSL3	DPYSL3	Mature neuron
HSPA5	HSPA5	Mature neuron
MAP1B	MAP1B	Mature neuron
CRMP1	CRMP1	Mature neuron
CRABP2	CRABP2	Mature neuron
MAPT	MAPT	Mature neuron
NEFL	NEFL	Mature neuron
MEF2C	MEF2C	Mature neuron
ZEB2	ZEB2	Mature neuron
ITM2C	ITM2C	Negative regulation of neuron projection
CNTN2	CNTN2	Negative regulation of neuron projection
SERPINF1	SERPINF1	Negative regulation of neuron projection
Neurofilament-M	NEFM	Excitatory neuron
VGLUT2	SLC17A6	Excitatory neuron
Somatostatin	SST	Inhibitory neuron
EBF1	EBF1	Developing striatal neuron

4.2.1 Early stage cells

4.2.2 Late stage cells

4.3 DEG GO enrichment

4.3.1 Early stage cells

4.3.2 Late stage cells

5 Gene Set Enrichment Analysis by Factor

Target genes: Genes w/ non-zero loadings in each factor (PIP cutoff at 0.95);
Backgroud genes: all 6000 genes used in factor analysis;
Statistical test: hypergeometric test (over-representation test);
Only GO terms/pathways that satisfy fold change \(\geq\) 2 and test FDR \(<\) 0.05 are shown below.

5.1 GO Slim Over-Representation Analysis

Gene sets: Gene ontology "Biological Process" (non-redundant).

Factor 1 : 7 significant GO terms

GeneSet	description	enrichRatio	pValue	FDR	GeneRatio	geneSymbols
GO:0006414	translational elongation	4.53	3.25e-09	2.39e-06	21/109	MRPL37; MRPL9; MRPS9; MRPL44; MRPS22; MRPL47; MRPS30; MRPL22; MRPS18B; MRPS10; EEF1A1; MRPL50; MRPS2; MRPS35; MRPL42; MRPS34; ERAL1; MRPL10; EIF4A3; GADD45GIP1; MRPL39
GO:0140053	mitochondrial gene expression	4.06	5.70e-08	2.09e-05	20/116	MRPL37; MRPL9; MRPS9; MRPL44; MRPS22; MRPL47; MRPS30; MRPL22; MRPS18B; MRPS10; TBRG4; MRPL50; MRPS2; MRPS35; MRPL42; MRPS34; ERAL1; MRPL10; GADD45GIP1; MRPL39
GO:0016072	rRNA metabolic process	3.03	2.40e-06	5.88e-04	22/171	RPF1; WDR43; MRPS9; NIFK; RPSA; RRP9; ABT1; BYSL; RPL7L1; DDX56; DCAF13; WDR74; GTPBP4; NGDN; RPS27L; RPS2; RSL1D1; NOB1; EIF4A3; GLTSCR2; RRP1B; RRP1
GO:0032984	protein-containing complex disassembly	2.57	2.36e-05	2.89e-03	23/211	PEX14; STMN1; MRPL37; MRPL9; MRPS9; MRPL44; MRPS22; MRPL47; MRPS30; MRPL22; MRPS18B; MRPS10; STMN4; STMN2; MRPL50; MRPS2; MRPS35; MRPL42; MRPS34; ERAL1; MRPL10; GADD45GIP1; MRPL39
GO:0034470	ncRNA processing	2.53	1.92e-05	2.82e-03	24/223	RPF1; WDR43; MRPS9; MRPL44; RPSA; RRP9; ABT1; BYSL; RPL7L1; DDX56; DCAF13; WDR74; GTPBP4; NGDN; RPS27L; RPS2; RSL1D1; NOB1; EIF4A3; TP53RK; GLTSCR2; TRMU; RRP1B; RRP1
GO:0006091	generation of precursor metabolites and energy	2.37	3.94e-05	4.13e-03	25/248	SDHB; HMGCL; NDUFS2; NDUFB5; ADH5; SDHA; PRELID1; NDUFA4; TBRG4; PMPCB; COX6C; CYC1; SDHD; GLRX3; NDUFA9; ATP5B; TRAP1; COQ9; NCOR1; IDH3B; SIRT6; UQCRFS1; GLTSCR2; MT-CO3; MT-ND4
GO:0022613	ribonucleoprotein complex biogenesis	2.28	6.65e-06	1.22e-03	32/330	EIF3I; RPF1; WDR43; MRPS9; RPSA; RRP9; BRIX1; MRPL22; ABT1; BYSL; RPL7L1; DDX56; DCAF13; EIF3E; MRPS2; WDR74; GTPBP4; PRMT5; NGDN; RPS27L; RPS2; RSL1D1; NOB1; RPL23A; ERAL1; MRPL10; EIF4A3; GLTSCR2; EIF3D; RRP1B; RRP1

Factor 2 : 28 significant GO terms

GeneSet	description	enrichRatio	pValue	FDR	GeneRatio	geneSymbols
GO:0070972	protein localization to endoplasmic reticulum	9.33	0.00e+00	0.00e+00	84/119	RPL22; RPL11; RPS8; RPL5; RPS27; SRP9; RPS7; RTN4; RPS27A; RPL31; RPL37A; RPL32; RPL15; RPSA; RPL14; RPL29; RPL24; RPL35A; RPL9; RPL34; RPS3A; RPL37; RPS23; RPS14; RPS18; RPS10; RPL10A; RPS12; RPS4X; RPL36A; RPL39; BCAP31; RPL10; RPS20; RPL7; RPL30; GPAA1; RPL8; RPS6; RPL35; RPL12; RPL7A; RPLP2; RPL27A; RPS13; SPCS2; RPS3; RPS25; RPS24; RPL41; RPL6; RPLP0; RPL21; RPS29; SRP14; RPS27L; RPL4; RPLP1; RPS17; RPS2; RPS15A; RPL13; RPL26; RPL23A; RPL23; RPL19; RPL27; RPL38; VAPA; DDRGK1; RPS21; RPS15; RPL36; RPS28; RPL18A; UBA52; RPS16; RPS19; RPL18; RPL13A; RPS11; RPS9; RPL28; RPS5; RPL3
GO:0006413	translational initiation	6.90	0.00e+00	0.00e+00	82/157	RPL22; RPL11; RPS8; RPL5; RPS27; RPS7; RPS27A; RPL31; RPL37A; RPL32; RPL15; RPSA; RPL14; RPL29; RPL24; EIF4A2; RPL35A; RPL9; RPL34; RPS3A; RPL37; RPS23; RPS14; RPS18; RPS10; RPL10A; RPS12; RPS4X; RPL36A; RPL39; MCTS1; RPL10; RPS20; RPL7; RPL30; PABPC1; RPL8; RPS6; RPL35; RPL12; RPL7A; RPLP2; RPL27A; RPS13; PPP1CA; RPS3; RPS25; RPS24; RPL41; RPL6; RPLP0; RPL21; RPS29; RPS27L; RPL4; RPLP1; RPS17; RPS2; RPS15A; RPL13; EIF4A1; RPL26; RPL23A; RPL23; RPL19; EIF1; RPL27; RPL38; RPS21; RPS15; RPL36; RPS28; RPL18A; UBA52; RPS16; RPS19; RPL18; RPL13A; RPS11; RPS9; RPL28; RPS5; RPL3
GO:0090150	establishment of protein localization to membrane	5.70	0.00e+00	0.00e+00	88/204	RPL22; RPL11; RPS8; RPL5; RPS27; SRP9; RPS7; YWHAQ; RPS27A; RPL31; RPL37A; RPL32; RPL15; RPSA; RPL14; RPL29; RPL24; RPL35A; NSG1; RPL9; RPL34; RPS3A; RPL37; RPS23; RPS14; RPS18; RPS10; RPL10A; RPS12; RPS4X; RPL36A; RPL39; RPL10; GDI1; RPS20; SDCBP; RPL7; RPL30; RPL8; RPS6; RPL35; RPL12; RPL7A; RPLP2; RPL27A; RPS13; RPS3; RPS25; RPS24; RPL41; RPL6; RPLP0; RPL21; RPS29; CALM1; HSP90AA1; SRP14; RPS27L; RPL4; RPLP1; RPS17; RPS2; RPS15A; ARL6IP1; RPL13; YWHAE; RPL26; RPL23A; RPL23; RPL19; RPL27; RPL38; YWHAB; RPS21; RPS15; RPL36; RPS28; RPL18A; UBA52; RPS16; RPS19; RPL18; RPL13A; RPS11; RPS9; RPL28; RPS5; RPL3; WRB
GO:0002181	cytoplasmic translation	5.43	1.11e-15	1.36e-13	30/73	RPL11; RPL31; RPL32; RPL15; TMA7; RPL29; RPL24; RPL35A; RPL9; RPS23; RPL10A; RPL36A; RPL39; MCTS1; RPL30; RPL8; RPL41; RPL6; RPLP0; RPS29; RPLP1; RPL26; RPL19; RPL38; RPS21; RPL36; RPS28; RPL18A; RPL18; RPL13A
GO:0006401	RNA catabolic process	4.76	0.00e+00	0.00e+00	85/236	RPL22; RPL11; RPS8; RPL5; RPS27; RPS7; RPS27A; RPL31; SSB; RPL37A; RPL32; RPL15; RPSA; RPL14; RPL29; RPL24; RPL35A; RPL9; RPL34; RPS3A; RPL37; RPS23; RPS14; RPS18; RPS10; RPL10A; RPS12; RPS4X; RPL36A; RPL39; RPL10; RPS20; RPL7; RPL30; PABPC1; RPL8; RPS6; RPL35; RPL12; SET; RPL7A; RNH1; RPLP2; RPL27A; RPS13; RPS3; RPS25; HSPA8; RPS24; RPL41; RPL6; RPLP0; UBC; RPL21; RPS29; SLIRP; RPS27L; RPL4; RPLP1; RPS17; RPS2; RPS15A; RPL13; RPL26; RPL23A; RPL23; RPL19; RPL27; RPL38; EIF4A3; YWHAB; RPS21; RPS15; RPL36; RPS28; RPL18A; UBA52; RPS16; RPS19; RPL18; RPL13A; RPS11; RPS9; RPL28; RPS5; RPL3
GO:0006605	protein targeting	4.56	0.00e+00	0.00e+00	90/261	RPL22; RPL11; RPS8; RPL5; RPS27; SRP9; RPS7; RPS27A; RPL31; RPL37A; RPL32; RPL15; RPSA; RPL14; RPL29; RPL24; RAB7A; RPL35A; RPL9; RPL34; RPS3A; RPL37; RPS23; RPS14; RPS18; RPS10; RPL10A; RPS12; TOMM7; RPS4X; RPL36A; RPL39; RPL10; GDI1; RPS20; SDCBP; RPL7; RPL30; RPL8; RPS6; RPL35; RPL12; RPL7A; RPLP2; RPL27A; RPS13; SPCS2; RPS3; RPS25; HSPA8; RPS24; RPL41; RPL6; RPLP0; UBC; RPL21; RPS29; HSP90AA1; SRP14; RPS27L; RPL4; RPLP1; RPS17; RPS2; RPS15A; ARL6IP1; UQCRC2; RPL13; RPL26; RPL23A; RPL23; RPL19; RPL27; RPL38; YWHAB; RPS21; RPS15; RPL36; RPS28; RPL18A; UBA52; ECH1; RPS16; RPS19; RPL18; RPL13A; RPS11; RPS9; RPL28; RPS5; RPL3
GO:0002576	platelet degranulation	4.41	6.95e-06	5.10e-04	12/36	TAGLN2; SCCPDH; TUBA4A; MAGED2; APLP2; PSAP; CD63; CALM1; SCG3; ALDOA; LGALS3BP; SOD1
GO:0051187	cofactor catabolic process	4.41	1.53e-03	4.00e-02	6/18	ACOT7; PRDX1; BLVRA; PRDX4; PRDX5; PRDX2
GO:0006081	cellular aldehyde metabolic process	3.92	6.13e-04	2.25e-02	8/27	PARK7; TKT; TALDO1; AKR1C1; PGAM1; TPI1; ESD; IDH2
GO:0006090	pyruvate metabolic process	3.78	9.19e-06	5.62e-04	14/49	ENO1; PDHB; VDAC1; PDHA1; PGK1; LDHA; PGAM1; GAPDH; TPI1; LDHB; PKM; ALDOA; ENO3; BSG
GO:0001906	cell killing	3.78	8.03e-04	2.56e-02	8/28	PRDX1; TUBB; HSP90AB1; RPL30; TUBB4B; GAPDH; RPS19; PVRL2
GO:0070671	response to interleukin-12	3.65	1.04e-03	3.17e-02	8/29	CDC42; HNRNPA2B1; PPIA; TALDO1; CFL1; RPLP0; PSME2; SOD1
GO:0009566	fertilization	3.57	2.96e-04	1.14e-02	10/37	PARK7; H3F3A; CCT7; CCT5; VDAC2; CCT2; REC8; SLIRP; ALDOA; PVRL2
GO:0016999	antibiotic metabolic process	3.42	1.67e-05	9.44e-04	15/58	PARK7; PRDX1; MDH1; PDHB; MDH2; AKR1B1; PDHA1; PRDX4; PRDX5; AKR1C1; ALDH2; ESD; IDH2; PRDX2; SOD1
GO:0072524	pyridine-containing compound metabolic process	3.41	9.00e-06	5.62e-04	16/62	ENO1; MDH1; TKT; PDHB; MDH2; PDHA1; PGK1; TALDO1; LDHA; PGAM1; GAPDH; TPI1; PKM; IDH2; ALDOA; ENO3
GO:0048857	neural nucleus development	3.41	1.67e-03	4.11e-02	8/31	CDC42; ATP5F1; YWHAQ; ACTB; DYNLL1; CALM1; CKB; YWHAE
GO:0099132	ATP hydrolysis coupled cation transmembrane transport	3.31	2.08e-03	4.49e-02	8/32	ATP6V0B; ATP5F1; ATP5G3; ATP6AP1; ATP5C1; ATP5B; ATP6V0D1; ATP5A1
GO:0045861	negative regulation of proteolysis	3.02	5.89e-07	4.80e-05	24/105	PARK7; RPL11; TMEM59; RPL5; AGT; RPS7; SERPINI1; HSP90AB1; NGFRAP1; SDCBP; PRDX5; APLP2; GAPDH; PEBP1; MAP1A; ARL6IP1; HERPUD1; GABARAPL2; YWHAE; SERPINF1; RPL23; DDRGK1; CST3; CDKN2D
GO:0005996	monosaccharide metabolic process	2.74	6.50e-05	2.99e-03	18/87	ENO1; MDH1; TKT; PDHB; MDH2; AKR1B1; PDHA1; PGK1; TALDO1; PPP1CA; PGAM1; GAPDH; TPI1; PKM; ALDOA; ENO3; G6PC3; CYB5R3
GO:0016051	carbohydrate biosynthetic process	2.61	7.04e-04	2.35e-02	14/71	ENO1; MDH1; TKT; MDH2; AKR1B1; PGK1; TALDO1; PPP1CA; PGAM1; GAPDH; TPI1; ALDOA; ENO3; G6PC3
GO:0036230	granulocyte activation	2.49	1.70e-07	1.79e-05	36/191	DDOST; ILF2; ARPC5; PSMD6; RAB7A; TUBB; CSNK2B; HSP90AB1; DYNLT1; PSMB1; PPIA; PRDX4; ATP6AP2; SDCBP; GGH; TUBB4B; PSMD13; GSTP1; NDUFC2; HSPA8; PSAP; PGAM1; CD63; CCT2; DYNLL1; ACTR10; HSP90AA1; SRP14; PKM; ALDOA; PSMD7; RAB5C; VAPA; CST3; FTL; CYB5R3
GO:0002446	neutrophil mediated immunity	2.47	2.24e-07	2.05e-05	36/193	DDOST; ILF2; ARPC5; PSMD6; RAB7A; TUBB; CSNK2B; HSP90AB1; DYNLT1; PSMB1; PPIA; PRDX4; ATP6AP2; SDCBP; GGH; TUBB4B; PSMD13; GSTP1; NDUFC2; HSPA8; PSAP; PGAM1; CD63; CCT2; DYNLL1; ACTR10; HSP90AA1; SRP14; PKM; ALDOA; PSMD7; RAB5C; VAPA; CST3; FTL; CYB5R3
GO:0071897	DNA biosynthetic process	2.36	1.35e-03	3.71e-02	15/84	RPS27A; CCT7; CTNNB1; CCT5; HSP90AB1; HNRNPA2B1; PPIA; PTGES3; CCT2; UBC; HSP90AA1; TERF2IP; CDKN2D; UBA52; UFD1L
GO:0052547	regulation of peptidase activity	2.31	1.54e-04	6.28e-03	22/126	PARK7; AGT; ARL6IP5; SERPINI1; MTCH1; CYCS; NGFRAP1; BCAP31; PRDX5; RPS3; APLP2; GAPDH; PEBP1; PSME2; RPS27L; ARL6IP1; HERPUD1; YWHAE; SERPINF1; DDRGK1; CST3; CDKN2D
GO:0031098	stress-activated protein kinase signaling cascade	2.23	1.31e-03	3.71e-02	17/101	CDC42; PRDX1; GADD45A; AGT; RPS27A; ARL6IP5; SKP1; EZR; AKR1B1; SDCBP; DNAJA1; GSTP1; RPS3; UBC; HACD3; UBA52; PRMT1
GO:0019058	viral life cycle	2.22	7.02e-04	2.35e-02	19/113	CDC42; RPS27A; RAB1A; RPSA; RAB7A; HSP90AB1; DYNLT1; PPIA; PABPC1; CHMP5; TSG101; HSPA8; UBC; PPIB; HACD3; VAPA; UBA52; PVRL2; CHMP2A
GO:0016072	rRNA metabolic process	2.16	6.52e-05	2.99e-03	28/171	RPL11; RPS8; RPL5; RPS27; RPS7; RPSA; RPL14; RPL35A; H2AFY; RPS14; RPL10A; RPL7; RPS6; RPL35; RPL7A; RPS24; NPM3; RPS27L; RPS17; RPS2; RPL26; RPL27; EIF4A3; RPS21; RPS15; RPS28; RPS16; RPS19; RPS9
GO:0016053	organic acid biosynthetic process	2.02	1.77e-03	4.11e-02	20/131	ACOT7; PARK7; ENO1; PHGDH; MGST3; CDO1; ASNS; PGK1; PTGDS; LDHA; PGAM1; GAPDH; TPI1; PTGES3; HACD3; PKM; ALDOA; ENO3; TECR; XBP1

Factor 3 : 10 significant GO terms

GeneSet	description	enrichRatio	pValue	FDR	GeneRatio	geneSymbols
GO:0070972	protein localization to endoplasmic reticulum	39.50	0.00e+00	0.00e+00	66/119	RPL11; RPS8; RPL5; RPS27; RPS7; RPS27A; RPL31; RPL37A; RPL32; RPL15; RPL14; RPL29; RPL24; RPL35A; RPL9; RPL34; RPS3A; RPL37; RPS23; RPS14; RPS18; RPL10A; RPS12; RPS4X; RPL36A; RPL39; RPL10; RPS20; RPL7; RPL30; RPL8; RPS6; RPL35; RPL12; RPL7A; RPLP2; RPL27A; RPS13; RPS3; RPS25; RPS24; RPL41; RPL6; RPLP0; RPL21; RPS29; RPLP1; RPS17; RPS15A; RPL13; RPL26; RPL23A; RPL23; RPL19; RPS15; RPL36; RPS28; RPL18A; RPS16; RPS19; RPL18; RPL13A; RPS9; RPL28; RPS5; RPL3
GO:0006413	translational initiation	30.00	0.00e+00	0.00e+00	66/157	RPL11; RPS8; RPL5; RPS27; RPS7; RPS27A; RPL31; RPL37A; RPL32; RPL15; RPL14; RPL29; RPL24; RPL35A; RPL9; RPL34; RPS3A; RPL37; RPS23; RPS14; RPS18; RPL10A; RPS12; RPS4X; RPL36A; RPL39; RPL10; RPS20; RPL7; RPL30; RPL8; RPS6; RPL35; RPL12; RPL7A; RPLP2; RPL27A; RPS13; RPS3; RPS25; RPS24; RPL41; RPL6; RPLP0; RPL21; RPS29; RPLP1; RPS17; RPS15A; RPL13; RPL26; RPL23A; RPL23; RPL19; RPS15; RPL36; RPS28; RPL18A; RPS16; RPS19; RPL18; RPL13A; RPS9; RPL28; RPS5; RPL3
GO:0002181	cytoplasmic translation	25.40	0.00e+00	0.00e+00	26/73	RPL11; RPL31; RPL32; RPL15; RPL29; RPL24; RPL35A; RPL9; RPS23; RPL10A; RPL36A; RPL39; RPL30; RPL8; RPL41; RPL6; RPLP0; RPS29; RPLP1; RPL26; RPL19; RPL36; RPS28; RPL18A; RPL18; RPL13A
GO:0090150	establishment of protein localization to membrane	23.40	0.00e+00	0.00e+00	67/204	RPL11; RPS8; RPL5; RPS27; RPS7; RPS27A; RPL31; RPL37A; RPL32; RPL15; RPL14; RPL29; RPL24; RPL35A; RPL9; RPL34; RPS3A; RPL37; RPS23; RPS14; GNB2L1; RPS18; RPL10A; RPS12; RPS4X; RPL36A; RPL39; RPL10; RPS20; RPL7; RPL30; RPL8; RPS6; RPL35; RPL12; RPL7A; RPLP2; RPL27A; RPS13; RPS3; RPS25; RPS24; RPL41; RPL6; RPLP0; RPL21; RPS29; RPLP1; RPS17; RPS15A; RPL13; RPL26; RPL23A; RPL23; RPL19; RPS15; RPL36; RPS28; RPL18A; RPS16; RPS19; RPL18; RPL13A; RPS9; RPL28; RPS5; RPL3
GO:0006401	RNA catabolic process	19.90	0.00e+00	0.00e+00	66/236	RPL11; RPS8; RPL5; RPS27; RPS7; RPS27A; RPL31; RPL37A; RPL32; RPL15; RPL14; RPL29; RPL24; RPL35A; RPL9; RPL34; RPS3A; RPL37; RPS23; RPS14; RPS18; RPL10A; RPS12; RPS4X; RPL36A; RPL39; RPL10; RPS20; RPL7; RPL30; RPL8; RPS6; RPL35; RPL12; RPL7A; RPLP2; RPL27A; RPS13; RPS3; RPS25; RPS24; RPL41; RPL6; RPLP0; RPL21; RPS29; RPLP1; RPS17; RPS15A; RPL13; RPL26; RPL23A; RPL23; RPL19; RPS15; RPL36; RPS28; RPL18A; RPS16; RPS19; RPL18; RPL13A; RPS9; RPL28; RPS5; RPL3
GO:0006605	protein targeting	18.00	0.00e+00	0.00e+00	66/261	RPL11; RPS8; RPL5; RPS27; RPS7; RPS27A; RPL31; RPL37A; RPL32; RPL15; RPL14; RPL29; RPL24; RPL35A; RPL9; RPL34; RPS3A; RPL37; RPS23; RPS14; RPS18; RPL10A; RPS12; RPS4X; RPL36A; RPL39; RPL10; RPS20; RPL7; RPL30; RPL8; RPS6; RPL35; RPL12; RPL7A; RPLP2; RPL27A; RPS13; RPS3; RPS25; RPS24; RPL41; RPL6; RPLP0; RPL21; RPS29; RPLP1; RPS17; RPS15A; RPL13; RPL26; RPL23A; RPL23; RPL19; RPS15; RPL36; RPS28; RPL18A; RPS16; RPS19; RPL18; RPL13A; RPS9; RPL28; RPS5; RPL3
GO:0016072	rRNA metabolic process	8.75	4.33e-15	3.97e-13	21/171	RPL11; RPS8; RPL5; RPS27; RPS7; RPL14; RPL35A; RPS14; RPL10A; RPL7; RPS6; RPL35; RPL7A; RPS24; RPS17; RPL26; RPS15; RPS28; RPS16; RPS19; RPS9
GO:0034470	ncRNA processing	6.71	9.44e-13	7.70e-11	21/223	RPL11; RPS8; RPL5; RPS27; RPS7; RPL14; RPL35A; RPS14; RPL10A; RPL7; RPS6; RPL35; RPL7A; RPS24; RPS17; RPL26; RPS15; RPS28; RPS16; RPS19; RPS9
GO:0022613	ribonucleoprotein complex biogenesis	6.70	0.00e+00	0.00e+00	31/330	RPL11; RPS8; RPL5; RPS27; RPS7; RPL14; RPL24; RPL35A; RPS23; RPS14; RPL10A; RPL10; RPL7; RPS6; RPL35; RPL12; RPL7A; RPS24; RPL6; RPLP0; RPS17; RPL26; RPL23A; RPS15; RPS28; RPS16; RPS19; RPL13A; RPS9; RPS5; RPL3
GO:0071826	ribonucleoprotein complex subunit organization	6.55	3.13e-10	2.30e-08	17/185	RPL11; RPL5; RPS27; RPL24; RPS23; RPS14; RPL10; RPL12; RPL6; RPLP0; RPL23A; RPS15; RPS28; RPS19; RPL13A; RPS5; RPL3

Factor 4 : 40 significant GO terms

GeneSet	description	enrichRatio	pValue	FDR	GeneRatio	geneSymbols
GO:0010737	protein kinase A signaling	8.28	1.69e-04	6.08e-03	5/11	RAB13; AKAP12; EZR; GAL; AKAP6
GO:0007218	neuropeptide signaling pathway	7.29	1.43e-03	2.84e-02	4/10	PCSK1N; GAL; SSTR2; PTH2
GO:0010644	cell communication by electrical coupling	7.01	4.30e-04	1.26e-02	5/13	ATP1B1; FKBP1B; SRI; ANK3; CALM1
GO:0035637	multicellular organismal signaling	4.66	1.33e-05	8.13e-04	11/43	ATP1B1; AGT; FKBP1B; SCN3A; SCN9A; CHRNA1; SRI; AKAP9; ANK3; ATP2B1; CALM1
GO:0010959	regulation of metal ion transport	4.42	3.03e-10	2.23e-07	24/99	SEPN1; ATP1B1; AGT; FKBP1B; GNAI2; SNCA; CAMK2B; SRI; AKAP9; CHD7; GAL; FXYD6; ANK3; KCNIP2; CD63; JPH4; AKAP6; CALM1; B2M; VAMP2; NEDD4L; NKAIN4; HOMER3; FXYD7
GO:0032409	regulation of transporter activity	4.27	4.17e-08	1.02e-05	19/81	SEPN1; ATP1B1; FKBP1B; SNCA; MEF2C; ACTB; SRI; AKAP9; TMSB4X; GAL; FXYD6; ANK3; KCNIP2; JPH4; AKAP6; CALM1; VAMP2; NEDD4L; FXYD7
GO:0031644	regulation of neurological system process	4.25	9.50e-04	2.17e-02	7/30	AGT; NRXN1; AKAP9; CBLN1; EIF4A3; BAIAP2; CELF4
GO:0099565	chemical synaptic transmission, postsynaptic	4.16	4.78e-04	1.35e-02	8/35	NRXN1; CHRNA1; SNCA; MEF2C; CBLN1; EIF4A3; BAIAP2; CELF4
GO:0034765	regulation of ion transmembrane transport	3.74	1.13e-08	4.14e-06	24/117	SEPN1; ATP1B1; AGT; FKBP1B; SCN3A; SCN9A; SNCA; MEF2C; SRI; AKAP9; TMSB4X; CHD7; GAL; FXYD6; ANK3; KCNIP2; CD63; JPH4; AKAP6; CALM1; VAMP2; NEDD4L; CACNA1A; FXYD7
GO:0006813	potassium ion transport	3.49	8.55e-04	2.09e-02	9/47	ATP1B1; AKAP9; GAL; ANK3; KCNIP2; CD63; AKAP6; VAMP2; NEDD4L
GO:0003012	muscle system process	3.42	4.86e-07	7.81e-05	21/112	LMNA; ATP1B1; AGT; FKBP1B; CHRNA1; MYL1; IGFBP5; MEF2C; HDAC2; CAMK2B; SRI; CALD1; KCNIP2; MYL6; AKAP6; CALM1; ACTC1; SSTR2; MYL12A; NEDD4L; PDE9A
GO:0034764	positive regulation of transmembrane transport	3.31	2.01e-04	6.71e-03	12/66	ATP1B1; AGT; CAPN10; SNCA; SRI; AKAP9; TMSB4X; GAL; ANK3; KCNIP2; AKAP6; CALM1
GO:0042391	regulation of membrane potential	3.19	1.60e-06	1.67e-04	21/120	MLLT11; ATP1B1; FKBP1B; NRXN1; SCN3A; SCN9A; CHRNA1; SNCA; MEF2C; SRI; AKAP9; ANK3; KCNIP2; AKAP6; CBLN1; MAPT; EIF4A3; BAIAP2; CELF4; NEDD4L; CACNA1A
GO:0072507	divalent inorganic cation homeostasis	3.18	9.29e-06	6.20e-04	18/103	SEPN1; SV2A; ATP1B1; AGT; FKBP1B; SNCA; SRI; CHD7; GNG3; ANK3; ATP2B1; HSP90B1; JPH4; AKAP6; CALM1; CALR; CACNA1A; SMDT1
GO:0001764	neuron migration	3.18	5.33e-04	1.40e-02	11/63	DNER; IGSF10; GPM6A; MAP1B; MEF2C; TUBB2B; MDGA1; CAMK2B; AUTS2; DCX; NRG1
GO:0019932	second-messenger-mediated signaling	3.17	3.14e-05	1.77e-03	16/92	SEPN1; ATP1B1; AGT; FKBP1B; NEUROD1; GNAI2; SRI; NRG1; GAL; JPH4; AKAP6; CALM1; MAPT; HOMER3; APLP1; PDE9A
GO:0070972	protein localization to endoplasmic reticulum	3.06	5.45e-06	4.00e-04	20/119	RPS27; RPS7; RPL37A; RPL29; RPS3A; RPL37; RPS14; RPS18; RPL10A; RPL39; RPS20; RPL12; RPLP2; RPL41; RPLP1; RPS15A; RPL23; RPS21; RPS11; RPL28
GO:0021953	central nervous system neuron differentiation	3.04	2.38e-03	4.26e-02	9/54	DRAXIN; LMO4; MAP2; SOX4; MDGA1; FZD1; MYCBP2; CBLN1; MAPT
GO:0031345	negative regulation of cell projection organization	3.04	8.02e-04	2.03e-02	11/66	DRAXIN; MAP2; ITM2C; PTPRG; NR2F1; DPYSL3; HDAC2; STMN2; B2M; EFNB3; NGFR
GO:0099177	regulation of trans-synaptic signaling	3.00	5.32e-07	7.81e-05	25/152	AGT; NRXN1; GNAI2; NSG1; SNCA; MEF2C; CPLX2; TUBB2B; GRM4; AKAP12; CAMK2B; AKAP9; PCDH17; JPH4; CALM1; RAB26; CBLN1; EFNB3; VAMP2; MAPT; EIF4A3; BAIAP2; CELF4; CACNA1A; RAB3A
GO:0043270	positive regulation of ion transport	2.95	1.04e-03	2.18e-02	11/68	ATP1B1; AGT; SNCA; SRI; AKAP9; TMSB4X; GAL; ANK3; KCNIP2; AKAP6; CALM1
GO:0060537	muscle tissue development	2.88	3.91e-05	1.91e-03	18/114	SEPN1; LMNA; AGT; ZBTB18; CHRNA1; IGFBP5; DNER; GPX1; MEF2C; FAM65B; UQCC2; MEOX2; NRG1; CHD7; MYL6; AKAP6; ACTC1; CALR
GO:0003013	circulatory system process	2.88	1.74e-04	6.08e-03	15/95	ATP1B1; AGT; FKBP1B; MYL1; GPX1; GNAI2; MEOX2; SRI; AKAP9; CHD7; KCNIP2; ATP2B1; CALM1; ACTC1; NEDD4L
GO:0007517	muscle organ development	2.87	6.70e-05	2.89e-03	17/108	SEPN1; ZBTB18; CHRNA1; DNER; GPX1; MEF2C; FAM65B; UQCC2; MEOX2; SRI; FZD1; NRG1; CHD7; MYL6; AKAP6; ACTC1; TCF12
GO:0072511	divalent inorganic cation transport	2.72	1.34e-04	5.18e-03	17/114	SEPN1; ATP1B1; AGT; FKBP1B; GNAI2; SNCA; GPM6A; CAMK2B; SRI; CHD7; ATP2B1; JPH4; AKAP6; CALM1; CACNA1A; HOMER3; SMDT1
GO:0097485	neuron projection guidance	2.71	5.31e-04	1.40e-02	14/94	DRAXIN; LHX9; NRXN1; ALCAM; GAP43; SPON2; PDLIM7; TUBB2B; EZR; DPYSL2; SPTAN1; FEZ1; MYCBP2; EFNB3
GO:0051235	maintenance of location	2.70	2.28e-04	7.28e-03	16/108	SEPN1; FKBP1B; SNCA; MDFI; EZR; SRI; AKAP9; TMSB4X; CHD7; FTH1; ANK3; HSP90B1; JPH4; AKAP6; CALM1; CALR
GO:0009914	hormone transport	2.69	9.04e-04	2.14e-02	13/88	MPC2; AGT; FKBP1B; NEUROD1; CAPN10; SOX4; UQCC2; SRI; CHD7; GAL; VAMP2; CACNA1A; SELM
GO:0010975	regulation of neuron projection development	2.63	1.10e-06	1.35e-04	29/201	DRAXIN; PTPRF; CRABP2; AGT; FKBP1B; MAP2; ITM2C; PTPRG; TNIK; MAP1B; MEF2C; NR2F1; DPYSL3; TUBB2B; HDAC2; CAMK2B; FZD1; NEFL; DPYSL2; STMN2; MYCBP2; B2M; SERPINF1; EFNB3; MAPT; NGFR; BAIAP2; NEDD4L; PREX1
GO:0050808	synapse organization	2.62	3.78e-05	1.91e-03	21/146	PTPRF; NRXN1; CHRNA1; DNER; GAP43; SNCA; GPM6A; MEF2C; TUBB; MDGA1; ACTB; CAMK2B; FZD1; NEFL; NRG1; ANK3; PCDH17; CBLN1; MAPT; BAIAP2; RAB3A
GO:0090130	tissue migration	2.60	1.25e-03	2.54e-02	13/91	RAB13; AGT; IQSEC1; GPX1; PTPRG; MEF2C; MEOX2; TMSB4X; GLIPR2; ATP5B; ACTC1; SERPINF1; CALR
GO:0061564	axon development	2.55	2.04e-06	1.88e-04	29/207	DRAXIN; STMN1; PTPRF; CRABP2; LHX9; FKBP1B; NRXN1; MAP2; ALCAM; GAP43; SPON2; MAP1B; NREP; PDLIM7; TUBB2B; EZR; AUTS2; NEFM; NEFL; DPYSL2; SPTAN1; FEZ1; ANK3; MYCBP2; EFNB3; MAPT; NGFR; BAIAP2; RAB3A
GO:0023061	signal release	2.52	4.54e-05	2.08e-03	22/159	WLS; SV2A; MPC2; AGT; FKBP1B; NRXN1; NEUROD1; CAPN10; SNCA; MEF2C; CPLX2; SOX4; UQCC2; GRM4; SRI; CHD7; GAL; CALM1; VAMP2; CACNA1A; RAB3A; SELM
GO:0090150	establishment of protein localization to membrane	2.50	4.68e-06	3.81e-04	28/204	RPS27; ATP1B1; RPS7; REEP1; RPL37A; RPL29; NSG1; RPS3A; RPL37; RPS14; RPS18; RPL10A; RPL39; RPS20; RPL12; RPLP2; ANK3; RPL41; CALM1; RPLP1; RAB26; RPS15A; VAMP2; RPL23; RAB31; RPS21; RPS11; RPL28
GO:0006413	translational initiation	2.44	1.12e-04	4.57e-03	21/157	RPS27; RPS7; RPL37A; EIF1B; RPL29; RPS3A; RPL37; RPS14; RPS18; RPL10A; RPL39; RPS20; RPL12; RPLP2; RPL41; RPLP1; RPS15A; RPL23; RPS21; RPS11; RPL28
GO:0051961	negative regulation of nervous system development	2.38	1.95e-03	3.67e-02	14/107	DRAXIN; PBX1; MAP2; ITM2C; PTPRG; NR2F1; DPYSL3; HDAC2; NRG1; STMN2; B2M; EFNB3; NGFR; CALR
GO:0010721	negative regulation of cell development	2.36	1.53e-03	2.96e-02	15/116	DRAXIN; PBX1; MAP2; ITM2C; PTPRG; NR2F1; DPYSL3; HDAC2; NRG1; STMN2; GAL; B2M; EFNB3; NGFR; CALR
GO:0050769	positive regulation of neurogenesis	2.29	2.71e-04	8.29e-03	21/167	CRABP2; AGT; FKBP1B; NEUROD1; MAP1B; MEF2C; DPYSL3; TUBB2B; HDAC2; CAMK2B; FZD1; NEFL; STMN2; TCF12; SERPINF1; MAPT; NGFR; BAIAP2; TCF4; NEDD4L; PCP4
GO:0031346	positive regulation of cell projection organization	2.18	1.00e-03	2.17e-02	19/159	CRABP2; AGT; FKBP1B; CDC42EP3; GPM6A; MAP1B; DPYSL3; TUBB2B; FAM65B; CAMK2B; AUTS2; FZD1; NEFL; STMN2; SERPINF1; MAPT; NGFR; BAIAP2; NEDD4L
GO:0022604	regulation of cell morphogenesis	2.08	1.01e-03	2.17e-02	21/184	DRAXIN; EPB41; RHOC; CRABP2; CDC42EP3; MAP2; TNIK; MAP1B; TUBB2B; EZR; CAMK2B; NEFL; DPYSL2; MYCBP2; EFNB3; MAPT; NGFR; BAIAP2; NEDD4L; PREX1; CALR

Factor 5 : 18 significant GO terms

GeneSet	description	enrichRatio	pValue	FDR	GeneRatio	geneSymbols
GO:0070972	protein localization to endoplasmic reticulum	6.14	0.00e+00	0.00e+00	44/119	RPS8; RPL5; RPS27; RPL31; RPL32; RPL15; RPL14; RPL24; SEC62; RPL35A; RPL34; RPS3A; RPS23; RPS14; RPS18; RPL10A; RPS4X; RPL36A; RPL10; RPS20; RPL7; RPL30; RPL12; RPL7A; RPLP2; SPCS2; RPS3; RPS25; RPS24; RPL6; RPLP0; RPS29; RPS27L; RPL4; RPLP1; RPS15A; RPL26; RPL23; RPS21; RPS28; RPL18; RPS9; RPL28; RPS5; RPL3
GO:0006413	translational initiation	5.61	0.00e+00	0.00e+00	53/157	RPS8; RPL5; RPS27; DDX1; RPL31; RPL32; RPL15; RPL14; RPL24; EIF4A2; RPL35A; RPL34; RPS3A; RPS23; RPS14; RPS18; RPL10A; HSPB1; RPS4X; RPL36A; RPL10; RPS20; RPL7; RPL30; PABPC1; EIF3E; RPL12; RPL7A; RPLP2; POLR2G; PPP1CA; RPS3; RPS25; RPS24; RPL6; RPLP0; RPS29; EIF5; EIF3J; RPS27L; RPL4; RPLP1; RPS15A; EIF4A1; RPL26; RPL23; EIF6; RPS21; RPS28; RPL18; RPS9; RPL28; RPS5; RPL3
GO:0002181	cytoplasmic translation	4.78	7.27e-10	8.89e-08	21/73	RPL31; RPL32; RPL15; RPL24; RPL35A; RPS23; RPL10A; RPL36A; RPL30; EIF3E; RPL6; RPLP0; RPS29; EIF5; EIF3J; RPLP1; RPL26; RPS21; EEF2; RPS28; RPL18
GO:0010257	NADH dehydrogenase complex assembly	4.71	4.13e-08	3.03e-06	17/60	NDUFB4; NDUFC1; NDUFS6; NDUFS4; NDUFB11; NDUFB9; NDUFA8; NDUFS3; NDUFS8; NDUFC2; NDUFB8; NDUFA12; NDUFB10; NDUFAB1; NDUFV2; NDUFS7; NDUFA6
GO:0090150	establishment of protein localization to membrane	4.15	0.00e+00	0.00e+00	51/204	RPS8; RPL5; RPS27; RPL31; RPL32; RPL15; RPL14; RPL24; SEC62; RPL35A; RPL34; RPS3A; RPS23; RPS14; GNB2L1; RPS18; RPL10A; CD24; GOPC; RPS4X; RPL36A; RPL10; RPS20; RPL7; RPL30; RPL12; RPL7A; RPLP2; RPS3; RPS25; RPS24; RPL6; RPLP0; RPS29; HSP90AA1; RPS27L; RPL4; RPLP1; RAB26; RPS15A; VPS35; RPL26; RPL23; NMT1; RPS21; RPS28; PDCD5; RPL18; RPS9; RPL28; RPS5; RPL3
GO:0006401	RNA catabolic process	3.94	0.00e+00	0.00e+00	56/236	RPS8; MAGOH; RPL5; RBM8A; RPS27; RPL31; RPL32; LSM3; RPL15; RPL14; RPL24; RPL35A; RPL34; RPS3A; RPS23; HNRNPA0; RPS14; RPS18; RPL10A; HSPB1; RPS4X; RPL36A; UPF3B; RPL10; RPS20; RPL7; RPL30; PABPC1; EIF3E; EXOSC4; RPL12; RPL7A; RPLP2; POLR2G; RPS3; RPS25; RPS24; EXOSC1; RPL6; RPLP0; RPS29; SLIRP; RPS27L; RPL4; RPLP1; RPS15A; RPL26; RPL23; RPS21; RPS28; HNRNPM; C19orf43; RPL18; RPS9; RPL28; RPS5; RPL3
GO:0006414	translational elongation	3.81	3.20e-09	3.35e-07	25/109	AURKAIP1; MRPS5; MRPL47; MRPS18C; MRPL22; GNB2L1; MRPS18A; EEF1A1; MRPL18; MRPL32; MRPL13; RPLP2; MRPL21; MRPL51; RPLP1; MRPL46; MRPL28; MRPL27; MRPS23; ICT1; MRPS7; MRPS26; EEF2; GADD45GIP1; MRPL40
GO:1902600	proton transmembrane transport	3.67	2.05e-06	1.16e-04	17/77	ATP6V0B; COX5B; ATP5G3; COX7C; COX7A2; TMSB4X; COX7B; COX6C; COX8A; ATP5B; COX6A1; ATP5E; NDUFS7; COX6B1; ATP5O; MT-CO1; MT-CYB
GO:0006605	protein targeting	3.37	4.44e-16	6.52e-14	53/261	ATPIF1; RPS8; RPL5; RPS27; RPL31; RPL32; RPL15; RPL14; RPL24; SEC62; RPL35A; RPL34; RPS3A; RPS23; RPS14; RPS18; RPL10A; SLC25A6; RPS4X; RPL36A; RPL10; RPS20; RPL7; RPL30; RPL12; RPL7A; PMPCA; RPLP2; AIP; SPCS2; RPS3; RPS25; RPS24; RPL6; RPLP0; RPS29; HSP90AA1; RPS27L; RPL4; RPLP1; RPS15A; RPL26; RPL23; RPS21; RPS28; UBL5; PDCD5; ECH1; RPL18; RPS9; RPL28; RPS5; UBE2L3; RPL3
GO:0033108	mitochondrial respiratory chain complex assembly	3.25	1.19e-05	5.58e-04	17/87	NDUFB4; NDUFC1; NDUFS6; NDUFS4; NDUFB11; NDUFB9; NDUFA8; NDUFS3; NDUFS8; NDUFC2; NDUFB8; NDUFA12; NDUFB10; NDUFAB1; NDUFV2; NDUFS7; NDUFA6
GO:0140053	mitochondrial gene expression	3.01	4.00e-06	2.09e-04	21/116	AURKAIP1; MRPS5; MRPL47; MRPS18C; MRPL22; MRPS18A; MRPL18; MALSU1; MRPL32; MRPL13; MRPL21; MRPL51; MRPL46; MRPL28; MRPL27; MRPS23; ICT1; MRPS7; MRPS26; GADD45GIP1; MRPL40
GO:0009141	nucleoside triphosphate metabolic process	2.90	1.53e-08	1.40e-06	33/189	ATPIF1; PARP1; COX5B; ATP5G3; NDUFB4; NDUFC1; NDUFS6; NDUFS4; COX7C; COX7A2; TMSB4X; NDUFB9; NDUFA8; NDUFS3; NDUFS8; NDUFC2; NDUFB8; TPI1; ATP5B; NDUFA12; COX6A1; RAN; NDUFB10; NDUFAB1; NDUFV2; EIF6; ATP5E; NDUFS7; UQCRFS1; NDUFA6; ATP5O; MT-CO1; MT-CYB
GO:0009123	nucleoside monophosphate metabolic process	2.73	1.18e-07	7.86e-06	32/195	ATPIF1; PARP1; COX5B; ATP5G3; NDUFB4; NDUFC1; NDUFS6; NDUFS4; COX7C; COX7A2; TMSB4X; NDUFB9; NDUFA8; NDUFS3; NDUFS8; NDUFC2; NDUFB8; TPI1; ATP5B; NDUFA12; COX6A1; NDUFB10; NDUFAB1; NDUFV2; EIF6; ATP5E; NDUFS7; UQCRFS1; NDUFA6; ATP5O; MT-CO1; MT-CYB
GO:0071826	ribonucleoprotein complex subunit organization	2.42	1.22e-05	5.58e-04	27/185	RPL5; RPS27; DDX1; LSM3; RPL24; YTHDC1; RPS23; RPS14; MRPL22; SNRPC; HSP90AB1; RPL10; EIF3E; RPL12; RPL6; RPLP0; HSP90AA1; EIF5; EIF3J; RPS27L; MRPS7; SNRPB; EIF6; PRPF6; RPS28; RPS5; RPL3
GO:0006091	generation of precursor metabolites and energy	2.41	4.42e-07	2.70e-05	36/248	SDHB; ATPIF1; COX5B; NDUFB4; NDUFC1; NDUFS6; NDUFS4; COX7C; COX7A2; COX7B; COX6C; NDUFB9; NDUFA8; NDUFS3; COX8A; PPP1CA; NDUFS8; NDUFC2; NDUFB8; TPI1; ATP5B; NDUFA12; COX6A1; VIMP; NDUFB10; NDUFAB1; NDUFV2; EIF6; ATP5E; NDUFS7; UQCRFS1; COX6B1; NDUFA6; ATP5O; MT-CO1; MT-CYB
GO:0022613	ribonucleoprotein complex biogenesis	2.32	3.24e-08	2.65e-06	46/330	RPS8; RPL5; RPS27; DDX1; CEBPZ; LSM3; RPL14; RPL24; RPL35A; YTHDC1; RPS23; RPS14; MRPL22; SNRPC; RPL10A; HSP90AB1; MALSU1; RPL10; RPL7; DCAF13; EIF3E; EXOSC4; RPL12; RPL7A; TRMT112; RPS24; EXOSC1; NPM3; RPL6; RPLP0; RAN; HSP90AA1; EIF5; EIF3J; RPS27L; RPL26; DDX52; MRPS7; SNRPB; EIF6; RPS21; PRPF6; RPS28; RPS9; RPS5; RPL3
GO:0009259	ribonucleotide metabolic process	2.13	2.09e-05	9.01e-04	33/257	ATPIF1; PARP1; COX5B; ATP5G3; NDUFB4; NDUFC1; NDUFS6; NDUFS4; COX7C; COX7A2; TMSB4X; NDUFB9; NDUFA8; NDUFS3; NDUFS8; NDUFC2; NDUFB8; TPI1; ATP5B; NDUFA12; COX6A1; RAN; NDUFB10; NDUFAB1; NDUFV2; EIF6; ATP5E; NDUFS7; UQCRFS1; NDUFA6; ATP5O; MT-CO1; MT-CYB
GO:0016072	rRNA metabolic process	2.04	1.26e-03	4.64e-02	21/171	RPS8; RPL5; RPS27; RPL14; RPL35A; RPS14; RPL10A; RPL7; DCAF13; EXOSC4; RPL7A; TRMT112; RPS24; EXOSC1; NPM3; RPS27L; RPL26; DDX52; RPS21; RPS28; C19orf43; RPS9

Factor 6 : 12 significant GO terms

GeneSet	description	enrichRatio	pValue	FDR	GeneRatio	geneSymbols
GO:0051131	chaperone-mediated protein complex assembly	12.30	2.04e-04	0.018682	4/11	HSPD1; HSP90AB1; CCT2; HSP90AA1
GO:0070670	response to interleukin-4	12.30	2.04e-04	0.018682	4/11	HSP90AB1; HSPA5; TUBA1B; XBP1
GO:0001818	negative regulation of cytokine production	5.05	3.92e-04	0.028773	7/47	HSP90AB1; TMSB4X; LAPTM4B; UBE2L6; HMGB1; C1QBP; PIN1
GO:0071897	DNA biosynthetic process	4.44	2.93e-05	0.009816	11/84	CENPF; HNRNPD; HSP90AB1; HNRNPA2B1; PPIA; DKC1; UBE2L6; HNRNPA1; CCT2; HNRNPC; HSP90AA1
GO:0006457	protein folding	4.18	4.28e-07	0.000314	17/138	PDIA6; FKBP1B; HSPD1; HSPE1; CANX; HSP90AB1; PPIA; PRDX4; HSPA5; HSPA8; PFDN5; CCT2; HSP90B1; HSP90AA1; PDIA3; PPIB; CALR
GO:0032200	telomere organization	4.13	2.83e-04	0.023113	9/74	GNL3; HNRNPD; HSP90AB1; HNRNPA2B1; DKC1; HNRNPA1; CCT2; HNRNPC; HSP90AA1
GO:0006338	chromatin remodeling	3.59	8.02e-04	0.049030	9/85	NASP; ANP32E; PTMA; HMGB2; NPM1; HELLS; NPM3; HMGB1; HNRNPC
GO:0006403	RNA localization	3.26	4.53e-05	0.009816	15/156	SFPQ; SRSF7; SSB; HNRNPA3; NOP58; NPM1; SRSF3; HNRNPA2B1; DKC1; HNRNPA1; PA2G4; CCT2; RAN; SRSF2; FBL
GO:1903311	regulation of mRNA metabolic process	3.07	5.35e-05	0.009816	16/177	SERBP1; PRDX6; SRSF7; PCBP4; HNRNPD; NPM1; SRSF3; HNRNPA2B1; PABPC1; HSPA8; HNRNPA1; HNRNPC; RBM25; C1QBP; SRSF2; HNRNPM
GO:0060249	anatomical structure homeostasis	2.95	6.83e-04	0.045598	12/138	PRDX1; NEUROD1; GNL3; HNRNPD; HSP90AB1; HNRNPA2B1; DKC1; HNRNPA1; CCT2; HNRNPC; HSP90AA1; ACTG1
GO:0006401	RNA catabolic process	2.59	1.67e-04	0.018682	18/236	SERBP1; SSB; PCBP4; HNRNPD; RPL37; NPM1; RPS4X; RPL39; RPL10; DKC1; PABPC1; RPS13; HSPA8; HNRNPC; HNRNPM; C19orf43; RPS9; RPL28
GO:0010608	posttranscriptional regulation of gene expression	2.49	7.97e-05	0.011700	21/286	SERBP1; EPRS; EIF5B; NCL; PCBP4; HNRNPD; NPM1; SOX4; HNRNPA2B1; RPS4X; RPL10; DKC1; PABPC1; HSPA8; PA2G4; RAN; HNRNPC; C1QBP; HNRNPM; CALR; RPS9

Factor 7 : 19 significant GO terms

GeneSet	description	enrichRatio	pValue	FDR	GeneRatio	geneSymbols
GO:0010257	NADH dehydrogenase complex assembly	6.83	0.00e+00	0.00e+00	30/60	NDUFS5; NDUFB3; NDUFAF3; NDUFB4; NDUFC1; NDUFS6; NDUFA2; NDUFB2; NDUFB11; NDUFA1; NDUFB9; TMEM261; NDUFB6; NDUFA8; NDUFS8; NDUFC2; NDUFB8; NDUFA12; NDUFB1; NDUFB10; NDUFAB1; NDUFS7; NDUFA11; NDUFA7; NDUFB7; NDUFA13; NDUFA3; NDUFA6; MT-ND3; MT-ND4
GO:0070972	protein localization to endoplasmic reticulum	6.54	0.00e+00	0.00e+00	57/119	RPL11; RPS8; RPL5; RPS27; RTN4; RPS27A; RPL37A; RPL32; RPL15; RPSA; SPCS1; RPL9; RPL34; RPS3A; RPL37; RPS23; RPS14; RPS18; RPL10A; RPS12; SEC61G; RPS4X; RPL39; RPL10; RPS20; RPL7; RPL30; RPS6; SEC61B; RPL35; RPL7A; RPL27A; RPS13; RPS3; RPS26; RPL41; RPL6; RPLP0; RPL21; RPS29; SRP14; RPL4; RPS17; RPS2; RPS15A; RPL13; RPL26; RPL23A; RPL23; RPL19; RPL18A; RPS16; RPS19; RPL18; RPL13A; RPS11; RPL3
GO:0033108	mitochondrial respiratory chain complex assembly	5.97	0.00e+00	0.00e+00	38/87	NDUFS5; COX20; NDUFB3; NDUFAF3; COX17; NDUFB4; NDUFC1; NDUFS6; NDUFA2; UQCC2; NDUFB2; NDUFB11; NDUFA1; UQCRB; NDUFB9; TMEM261; NDUFB6; NDUFA8; NDUFS8; NDUFC2; NDUFB8; COX14; NDUFA12; NDUFB1; NDUFB10; NDUFAB1; COA3; NDUFS7; NDUFA11; PET100; NDUFA7; NDUFB7; NDUFA13; NDUFA3; UQCR10; NDUFA6; MT-ND3; MT-ND4
GO:1902600	proton transmembrane transport	5.68	0.00e+00	0.00e+00	32/77	PARK7; ATP6V0B; COX5B; ATP5G3; COX17; ATP5I; COX7C; COX7A2; NDUFA4; ATP5J2; ATP6V1F; TMSB4X; COX7B; COX6C; ATP6V1G1; COX8A; ATP5L; ATP5G2; SLC25A3; COX6A1; COX5A; COX4I1; ATP5G1; ATP5H; ATP5A1; ATP5E; NDUFS7; COX6B1; ATP5J; ATP5O; MT-CO1; MT-ND4
GO:0006413	translational initiation	5.48	0.00e+00	0.00e+00	63/157	RPL11; RPS8; RPL5; RPS27; DDX1; RPS27A; RPL37A; RPL32; RPL15; RPSA; EIF4A2; RPL9; RPL34; RPS3A; RPL37; RPS23; RPS14; RPS18; RPL10A; RPS12; RPS4X; RPL39; MCTS1; RPL10; EIF4EBP1; RPS20; RPL7; RPL30; EIF3E; EIF3H; RPS6; RPL35; RPL7A; EIF3F; RPL27A; RPS13; RPS3; RPS26; RPL41; RPL6; RPLP0; RPL21; RPS29; EIF3J; RPL4; RPS17; RPS2; RPS15A; RPL13; RPL26; RPL23A; RPL23; RPL19; EIF1; RPL18A; EIF3K; RPS16; RPS19; RPL18; RPL13A; RPS11; EIF3L; RPL3
GO:0002181	cytoplasmic translation	5.24	3.40e-14	1.92e-12	28/73	RPL11; RPL32; RPL15; TMA7; RPL9; RPS23; RPL10A; RPL39; MCTS1; EIF4EBP1; RPL30; EIF3E; EIF3H; EIF3F; RPS26; RPL41; RPL6; RPLP0; RPS29; EIF3J; RPL26; RPL19; EEF2; RPL18A; EIF3K; RPL18; RPL13A; EIF3L
GO:0090150	establishment of protein localization to membrane	4.35	0.00e+00	0.00e+00	65/204	RPL11; RPS8; RPL5; RPS27; RPS27A; RPL37A; RPL32; RPL15; RPSA; RPL9; RPL34; RPS3A; RPL37; RPS23; RPS14; GNB2L1; RPS18; RPL10A; CD24; RPS12; FIS1; RPS4X; RPL39; RPL10; RPS20; RPL7; RPL30; YWHAZ; RPS6; SEC61B; RPL35; RPL7A; RPL27A; RPS13; TIMM10; RPS3; RPS26; RPL41; RPL6; RPLP0; RPL21; RPS29; CALM1; SRP14; RPL4; RPS17; RPS2; RPS15A; RPL13; VAMP2; RPL26; RPL23A; RPL23; RPL19; ROMO1; TIMM13; RPL18A; NDUFA13; PDCD5; RPS16; RPS19; RPL18; RPL13A; RPS11; RPL3
GO:0099132	ATP hydrolysis coupled cation transmembrane transport	4.27	5.84e-05	2.38e-03	10/32	ATP6V0B; ATP5G3; ATP6V1F; ATP5L; ATP5G2; ATP5G1; ATP5H; ATP5A1; ATP5E; ATP5O
GO:0009141	nucleoside triphosphate metabolic process	4.19	0.00e+00	0.00e+00	58/189	PARK7; ATPIF1; NDUFS5; UQCRH; COX5B; ATP5G3; NDUFB3; NDUFB4; ATP5I; NDUFC1; NDUFS6; COX7C; UQCRQ; NDUFA2; UQCC2; COX7A2; NDUFA4; CYCS; ATP5J2; NDUFB2; TMSB4X; NDUFA1; UQCRB; NDUFB9; NDUFB6; NDUFA8; AK1; NDUFS8; NDUFC2; ATP5L; NDUFB8; TPI1; ATP5G2; NDUFA12; COX6A1; RAN; NDUFB1; COX5A; NDUFB10; NDUFAB1; DCTPP1; COX4I1; ATP5G1; NME1; ATP5H; ATP5A1; ATP5E; NDUFS7; NDUFA7; NDUFB7; NDUFA3; UQCR10; NDUFA6; ATP5J; ATP5O; MT-CO1; MT-ND3; MT-ND4
GO:0009123	nucleoside monophosphate metabolic process	3.92	0.00e+00	0.00e+00	56/195	PARK7; ATPIF1; NDUFS5; UQCRH; COX5B; ATP5G3; NDUFB3; NDUFB4; ATP5I; NDUFC1; NDUFS6; COX7C; UQCRQ; NDUFA2; UQCC2; COX7A2; HDDC2; NDUFA4; CYCS; ATP5J2; NDUFB2; TMSB4X; NDUFA1; UQCRB; NDUFB9; NDUFB6; NDUFA8; AK1; NDUFS8; NDUFC2; ATP5L; NDUFB8; TPI1; ATP5G2; NDUFA12; COX6A1; NDUFB1; COX5A; NDUFB10; NDUFAB1; COX4I1; ATP5G1; ATP5H; ATP5A1; ATP5E; NDUFS7; NDUFA7; NDUFB7; NDUFA3; UQCR10; NDUFA6; ATP5J; ATP5O; MT-CO1; MT-ND3; MT-ND4
GO:0017004	cytochrome complex assembly	3.90	6.45e-04	2.49e-02	8/28	COX20; COX17; UQCC2; UQCRB; COX14; COA3; PET100; UQCR10
GO:0006605	protein targeting	3.72	0.00e+00	0.00e+00	71/261	RPL11; ATPIF1; RPS8; RPL5; RPS27; RPS27A; RPL37A; RPL32; RPL15; RPSA; SPCS1; RPL9; RPL34; RPS3A; RPL37; RPS23; RPS14; RPS18; RPL10A; RPS12; TOMM7; SEC61G; FIS1; SLC25A6; TIMM17B; RPS4X; RPL39; RPL10; RPS20; RPL7; RPL30; YWHAZ; RPS6; SEC61B; RPL35; RPL7A; RPL27A; RPS13; IMMP1L; TIMM10; RPS3; TIMM8B; RPS26; RPL41; RPL6; RPLP0; UBC; RPL21; RPS29; SRP14; RPL4; RPS17; RPS2; RPS15A; RPL13; RPL26; RPL23A; RPL23; RPL19; ROMO1; TIMM13; UBL5; RPL18A; NDUFA13; PDCD5; RPS16; RPS19; RPL18; RPL13A; RPS11; RPL3
GO:0006401	RNA catabolic process	3.59	0.00e+00	0.00e+00	62/236	RPL11; RPS8; RPL5; RPS27; RPS27A; RPL37A; RPL32; LSM3; RPL15; RPSA; RPL9; RPL34; RPS3A; RPL37; RPS23; RPS14; RPS18; RPL10A; RPS12; LSM5; LINC01420; RPS4X; RPL39; RPL10; RPS20; RPL7; RPL30; YWHAZ; EIF3E; RPS6; RPL35; RPL7A; RPL27A; RPS13; RNASEH2C; RPS3; RPS26; RPL41; RPL6; RPLP0; UBC; RPL21; RPS29; SLIRP; RPL4; RPS17; RPS2; RPS15A; RPL13; RPL26; RPL23A; RPL23; RPL19; LSM7; RPL18A; LSM4; RPS16; RPS19; RPL18; RPL13A; RPS11; RPL3
GO:0006091	generation of precursor metabolites and energy	3.47	0.00e+00	0.00e+00	63/248	PARK7; SH3BGRL3; ATPIF1; NDUFS5; UQCRH; COX20; COX5B; NDUFB3; COX17; NDUFB4; ATP5I; NDUFC1; NDUFS6; COX7C; GLRX; UQCRQ; NDUFA2; UQCC2; COX7A2; NDUFA4; CYCS; ATP5J2; NDUFB2; COX7B; NDUFA1; UQCRB; COX6C; NDUFB9; NDUFB6; NDUFA8; COX8A; NDUFS8; NDUFC2; ATP5L; CISD1; NDUFB8; TPI1; BLOC1S1; NDUFA12; COX6A1; HMGB1; NDUFB1; COX5A; NDUFB10; NDUFAB1; COX4I1; ATP5H; ATP5A1; ATP5E; NDUFS7; UQCR11; NDUFA7; NDUFB7; COX6B1; ETFB; NDUFA3; UQCR10; NDUFA6; ATP5J; ATP5O; MT-CO1; MT-ND3; MT-ND4
GO:0007006	mitochondrial membrane organization	3.34	5.54e-07	2.90e-05	21/86	ATPIF1; ATP5G3; ATP5I; TMEM14A; DYNLT1; ATP5J2; YWHAZ; TIMM10; ATP5L; ATP5G2; CALM1; ATP5G1; ATP5H; ATP5A1; ROMO1; ATP5E; TIMM13; NDUFA13; PDCD5; ATP5J; ATP5O
GO:0009259	ribonucleotide metabolic process	3.14	2.22e-16	1.36e-14	59/257	PARK7; ATPIF1; NDUFS5; UQCRH; COX5B; DBI; ATP5G3; NDUFB3; NDUFB4; ATP5I; NDUFC1; NDUFS6; COX7C; HINT1; UQCRQ; NDUFA2; UQCC2; COX7A2; NDUFA4; CYCS; ATP5J2; NDUFB2; TMSB4X; NDUFA1; UQCRB; NDUFB9; NDUFB6; NDUFA8; AK1; NDUFS8; NDUFC2; ATP5L; NDUFB8; TPI1; ATP5G2; NDUFA12; COX6A1; RAN; NDUFB1; COX5A; NDUFB10; NDUFAB1; COX4I1; ATP5G1; NME1; ATP5H; ATP5A1; ATP5E; NDUFS7; NDUFA7; NDUFB7; NDUFA3; UQCR10; NDUFA6; ATP5J; ATP5O; MT-CO1; MT-ND3; MT-ND4
GO:0006839	mitochondrial transport	2.42	1.73e-05	7.46e-04	26/147	ATPIF1; COX5B; ATP5I; TMEM14A; DYNLT1; TOMM7; ATP5J2; FIS1; SLC25A6; TIMM17B; YWHAZ; IMMP1L; TIMM10; TIMM8B; ATP5L; ATP5H; ATP5A1; ROMO1; ATP5E; TIMM13; UBL5; NDUFA13; PDCD5; SMDT1; ATP5J; ATP5O
GO:0070585	protein localization to mitochondrion	2.35	1.00e-03	3.68e-02	16/93	ATPIF1; TOMM7; FIS1; SLC25A6; TIMM17B; YWHAZ; IMMP1L; TIMM10; TIMM8B; DDIT3; CALM1; ROMO1; TIMM13; UBL5; NDUFA13; PDCD5
GO:0071826	ribonucleoprotein complex subunit organization	2.29	8.39e-06	4.11e-04	31/185	MRPL20; RPL11; RPL5; RPS27; SNRPE; DDX1; SNRPG; LSM3; RPSA; RPS23; RPS14; LINC01420; MCTS1; RPL10; EIF3E; EIF3H; EIF3F; SNRPF; RPL6; RPLP0; EIF3J; RPL23A; SNRPD1; LSM4; EIF3K; RPS19; SNRPD2; RPL13A; EIF3L; RPL3; SNU13

Factor 8 : 4 significant GO terms

GeneSet	description	enrichRatio	pValue	FDR	GeneRatio	geneSymbols
GO:0050954	sensory perception of mechanical stimulus	4.63	2.45e-04	0.04498	8/39	CASP3; FAM65B; POU3F4; NAV2; COL2A1; CACNB3; SRRM4; SIX1
GO:0070972	protein localization to endoplasmic reticulum	3.41	3.72e-06	0.00273	18/119	RPL32; RPSA; RPL34; RPS18; RPL36A; RPL10; RPL12; RPL27A; RPS13; RPS3; RPS26; RPL41; OS9; RPL6; RPLP0; RPS17; RPL26; RPL23
GO:0006413	translational initiation	2.59	1.70e-04	0.04158	18/157	RPL32; RPSA; RPL34; RPS18; RPL36A; RPL10; RPL12; RPL27A; RPS13; RPS3; RPS26; RPL41; RPL6; RPLP0; DENR; RPS17; RPL26; RPL23
GO:0090150	establishment of protein localization to membrane	2.43	8.08e-05	0.02965	22/204	RPL32; RPSA; NSG1; RPL34; GNB2L1; RPS18; RPL36A; RPL10; RPL12; RPL27A; RPS13; RPS3; CACNB3; RPS26; RPL41; RPL6; RPLP0; CALM1; RPS17; VAMP2; RPL26; RPL23

Factor 9 : 35 significant GO terms

GeneSet	description	enrichRatio	pValue	FDR	GeneRatio	geneSymbols
GO:0014075	response to amine	9.41	5.44e-04	0.028630	4/10	HDAC2; ASIC1; CALM1; NME1
GO:0048645	animal organ formation	8.56	8.26e-04	0.031152	4/11	GNG5; CTNNB1; ROBO1; SIX1
GO:0007586	digestion	7.24	1.67e-03	0.043405	4/13	NEUROD1; SST; NEUROG1; LIMA1
GO:0010644	cell communication by electrical coupling	7.24	1.67e-03	0.043405	4/13	RYR2; CAMK2D; ANK3; CALM1
GO:0035270	endocrine system development	4.41	1.96e-03	0.044935	6/32	PBX1; SIX3; NEUROD1; CDKN1C; SIX1; ONECUT2
GO:0035637	multicellular organismal signaling	4.38	3.73e-04	0.028630	8/43	RYR2; SCN3A; CHRNA1; ANK2; CAMK2D; ANK3; ATP2B1; CALM1
GO:0014074	response to purine-containing compound	4.22	1.09e-03	0.036375	7/39	JUN; RYR2; IGFBP5; SPARC; HDAC2; AKAP6; NME1
GO:0003007	heart morphogenesis	4.04	6.41e-05	0.015684	11/64	JUN; GNG5; RYR2; ID2; CTNNB1; ROBO1; IFT57; COL4A3BP; OLFM1; SIX1; ACTC1
GO:0045165	cell fate commitment	4.01	6.99e-04	0.030163	8/47	ID2; NEUROD1; CTNNB1; GAP43; CASP3; NEUROG1; SIX1; ONECUT2
GO:0008544	epidermis development	3.92	8.59e-05	0.015766	11/66	POU3F1; CRABP2; PKP4; IGFBP5; SATB1; CTNNB1; CASP3; HDAC2; AGPAT2; GAL; TNFRSF19
GO:0030048	actin filament-based movement	3.92	1.72e-03	0.043405	7/42	RYR2; ANK2; CAMK2D; TPM2; MYL6; ACTC1; TNNC2
GO:0003012	muscle system process	3.78	8.09e-07	0.000572	18/112	RYR2; CHRNA1; IGFBP5; ANK2; CAMK2D; SORBS2; COL4A3BP; NEUROG1; HDAC2; MTPN; TPM2; VCL; MYL6; AKAP6; CALM1; ACTC1; SSTR2; TNNC2
GO:0043588	skin development	3.72	5.79e-04	0.028630	9/57	STMN1; POU3F1; PKP4; IGFBP5; CTNNB1; CASP3; HDAC2; GAL; TNFRSF19
GO:0006814	sodium ion transport	3.42	2.02e-03	0.044935	8/55	SCN3A; CAMK2D; GLRX; SLC17A6; FXYD6; ANK3; ASIC1; NKAIN4
GO:0097305	response to alcohol	3.36	6.57e-04	0.030140	10/70	EEF1B2; CTNNB1; SPARC; HDAC2; LANCL2; TNC; ATP2B1; CALM1; ACTC1; MT-ND4
GO:0032409	regulation of transporter activity	3.20	5.54e-04	0.028630	11/81	RYR2; ANK2; CAMK2D; GLRX; ACTB; TMSB4X; GAL; FXYD6; ANK3; AKAP6; CALM1
GO:0060560	developmental growth involved in morphogenesis	3.17	3.33e-04	0.028630	12/89	DRAXIN; CRABP2; ZEB2; CTNNB1; ALCAM; MAP1B; TNC; OLFM1; GAL; VCL; SIX1; SYT4
GO:0048568	embryonic organ development	3.14	1.20e-04	0.017667	14/105	MFAP2; NES; PBX1; RYR2; ID2; NCOA1; SIX3; NEUROD1; CTNNB1; IFT57; NEUROG1; CTHRC1; CDKN1C; SIX1
GO:0043270	positive regulation of ion transport	3.11	2.11e-03	0.045645	9/68	RYR2; ANK2; GLRX; TMSB4X; GAL; ANK3; AKAP6; CALM1; SYT4
GO:0050673	epithelial cell proliferation	3.00	5.56e-04	0.028630	12/94	JUN; ID2; IGFBP5; SCG2; CTNNB1; ROBO1; IFT57; SPARC; CDKN1C; SIX1; PGF; NME1
GO:0097485	neuron projection guidance	3.00	5.56e-04	0.028630	12/94	DRAXIN; SHC1; EFNA3; LHX9; CNTN2; ROBO1; ALCAM; GAP43; SPON2; PDLIM7; ETV1; NCAM1
GO:0048880	sensory system development	2.88	8.14e-04	0.031152	12/98	MFAP2; JUN; NES; SIX3; ZEB2; NEUROD1; CTNNB1; HDAC2; CDKN1C; ATP2B1; MAB21L1; CELF4
GO:0051961	negative regulation of nervous system development	2.86	5.34e-04	0.028630	13/107	DRAXIN; PBX1; CNTN2; ID2; SIX3; ITM2C; CTNNB1; NR2F1; DPYSL3; HDAC2; B2M; LINGO1; SYT4
GO:0010959	regulation of metal ion transport	2.85	8.92e-04	0.031169	12/99	RYR2; CTNNB1; ANK2; CAMK2D; GLRX; GAL; FXYD6; ANK3; AKAP6; CALM1; B2M; NKAIN4
GO:0090130	tissue migration	2.84	1.49e-03	0.043405	11/91	JUN; ZEB2; SCG2; IQSEC1; ROBO1; SPARC; MEOX2; TMSB4X; ACTC1; PFN1; MAPRE2
GO:0061564	axon development	2.84	1.56e-06	0.000572	25/207	DRAXIN; STMN1; JUN; S100A6; SHC1; EFNA3; CRABP2; LHX9; CNTN2; ZEB2; ROBO1; ALCAM; GAP43; SPON2; CASP3; MAP1B; PDLIM7; ETV1; TNC; OLFM1; NCAM1; ANK3; VCL; LINGO1; ADARB1
GO:0010721	negative regulation of cell development	2.84	3.51e-04	0.028630	14/116	DRAXIN; PBX1; CNTN2; ID2; SIX3; ITM2C; CTNNB1; NR2F1; DPYSL3; HDAC2; GAL; B2M; LINGO1; SYT4
GO:0007517	muscle organ development	2.83	5.85e-04	0.028630	13/108	RYR2; CHRNA1; CTNNB1; NEUROG1; ETV1; MEOX2; MTPN; MYL6; AKAP6; SIX1; ACTC1; TCF12; ADARB1
GO:0007389	pattern specification process	2.57	2.25e-03	0.047172	12/110	PBX1; SIX3; ZEB2; NEUROD1; CTNNB1; ROBO1; IFT57; NEUROG1; MEOX2; PBX3; EMX2; SIX1
GO:0007015	actin filament organization	2.50	8.49e-04	0.031152	15/141	STMN1; ARPC5; CDC42EP3; CD47; WDR1; SORBS2; DPYSL3; CAP2; MTPN; TMSB4X; TPM2; CFL1; LIMA1; ACTC1; PFN1
GO:0030900	forebrain development	2.44	1.62e-03	0.043405	14/135	DRAXIN; POU3F1; ARPC5; CNTN2; ID2; SIX3; ZEB2; NEUROD1; CTNNB1; ROBO1; CASP3; EMX2; NME1; SSTR2
GO:0002009	morphogenesis of an epithelium	2.42	1.73e-03	0.043405	14/136	PBX1; RYR2; ZEB2; IGFBP5; CTNNB1; IFT57; WDR1; CTHRC1; TNC; CFL1; VCL; SIX1; PGF; PFN1
GO:0051098	regulation of binding	2.27	1.67e-03	0.043405	16/166	STMN1; EPB41; JUN; NES; ID2; NEUROD1; CTNNB1; HDAC2; ACTB; TMSB4X; CTHRC1; CALM1; B2M; CCPG1; WFIKKN1; NME1
GO:0050769	positive regulation of neurogenesis	2.25	1.77e-03	0.043405	16/167	CRABP2; ID2; NCOA1; ZEB2; NEUROD1; CTNNB1; ROBO1; MAP1B; NEUROG1; DPYSL3; HDAC2; TCF12; NME1; SYT4; TCF4; PCP4
GO:0009636	response to toxic substance	2.23	2.01e-03	0.044935	16/169	JUN; EPHX1; CHRNA1; EEF1B2; CASP3; SPARC; HDAC2; ACTB; PON2; TNC; RPS3; ASIC1; CALM1; ACTC1; NXN; MT-ND4

Factor 11 : 12 significant GO terms

GeneSet	description	enrichRatio	pValue	FDR	GeneRatio	geneSymbols
GO:0070972	protein localization to endoplasmic reticulum	30.90	0.00e+00	0.00e+00	77/119	RPL22; RPL11; RPS8; RPL5; RPS27; RPS7; RPS27A; RPL31; RPL37A; RPL32; RPL15; RPSA; RPL14; RPL29; RPL24; RPL35A; RPL9; RPL34; RPS3A; RPL37; RPS23; RPS14; RPS18; RPS10; RPL10A; RPS12; RPS4X; RPL36A; RPL39; RPL10; RPS20; RPL7; RPL30; RPL8; RPS6; RPL35; RPL12; RPL7A; RPLP2; RPL27A; RPS13; RPS3; RPS25; RPS24; RPL41; RPL6; RPLP0; RPL21; RPS29; RPL4; RPLP1; RPS17; RPS2; RPS15A; RPL13; RPL26; RPL23A; RPL23; RPL19; RPL27; RPL38; RPL17; RPS21; RPS15; RPL36; RPS28; RPL18A; UBA52; RPS16; RPS19; RPL18; RPL13A; RPS11; RPS9; RPL28; RPS5; RPL3
GO:0006413	translational initiation	23.40	0.00e+00	0.00e+00	77/157	RPL22; RPL11; RPS8; RPL5; RPS27; RPS7; RPS27A; RPL31; RPL37A; RPL32; RPL15; RPSA; RPL14; RPL29; RPL24; RPL35A; RPL9; RPL34; RPS3A; RPL37; RPS23; RPS14; RPS18; RPS10; RPL10A; RPS12; RPS4X; RPL36A; RPL39; RPL10; RPS20; RPL7; RPL30; RPL8; RPS6; RPL35; RPL12; RPL7A; RPLP2; RPL27A; RPS13; RPS3; RPS25; RPS24; RPL41; RPL6; RPLP0; RPL21; RPS29; RPL4; RPLP1; RPS17; RPS2; RPS15A; RPL13; RPL26; RPL23A; RPL23; RPL19; RPL27; RPL38; RPL17; RPS21; RPS15; RPL36; RPS28; RPL18A; UBA52; RPS16; RPS19; RPL18; RPL13A; RPS11; RPS9; RPL28; RPS5; RPL3
GO:0002181	cytoplasmic translation	19.60	0.00e+00	0.00e+00	30/73	RPL11; RPL31; RPL32; RPL15; RPL29; RPL24; RPL35A; RPL9; RPS23; RPL10A; RPL36A; RPL39; RPL30; RPL8; RPL41; RPL6; RPLP0; RPS29; RPLP1; RPL26; RPL19; RPL38; RPL17; RPS21; EEF2; RPL36; RPS28; RPL18A; RPL18; RPL13A
GO:0090150	establishment of protein localization to membrane	18.30	0.00e+00	0.00e+00	78/204	RPL22; RPL11; RPS8; RPL5; RPS27; RPS7; RPS27A; RPL31; RPL37A; RPL32; RPL15; RPSA; RPL14; RPL29; RPL24; RPL35A; RPL9; RPL34; RPS3A; RPL37; RPS23; RPS14; GNB2L1; RPS18; RPS10; RPL10A; RPS12; RPS4X; RPL36A; RPL39; RPL10; RPS20; RPL7; RPL30; RPL8; RPS6; RPL35; RPL12; RPL7A; RPLP2; RPL27A; RPS13; RPS3; RPS25; RPS24; RPL41; RPL6; RPLP0; RPL21; RPS29; RPL4; RPLP1; RPS17; RPS2; RPS15A; RPL13; RPL26; RPL23A; RPL23; RPL19; RPL27; RPL38; RPL17; RPS21; RPS15; RPL36; RPS28; RPL18A; UBA52; RPS16; RPS19; RPL18; RPL13A; RPS11; RPS9; RPL28; RPS5; RPL3
GO:0006401	RNA catabolic process	15.60	0.00e+00	0.00e+00	77/236	RPL22; RPL11; RPS8; RPL5; RPS27; RPS7; RPS27A; RPL31; RPL37A; RPL32; RPL15; RPSA; RPL14; RPL29; RPL24; RPL35A; RPL9; RPL34; RPS3A; RPL37; RPS23; RPS14; RPS18; RPS10; RPL10A; RPS12; RPS4X; RPL36A; RPL39; RPL10; RPS20; RPL7; RPL30; RPL8; RPS6; RPL35; RPL12; RPL7A; RPLP2; RPL27A; RPS13; RPS3; RPS25; RPS24; RPL41; RPL6; RPLP0; RPL21; RPS29; RPL4; RPLP1; RPS17; RPS2; RPS15A; RPL13; RPL26; RPL23A; RPL23; RPL19; RPL27; RPL38; RPL17; RPS21; RPS15; RPL36; RPS28; RPL18A; UBA52; RPS16; RPS19; RPL18; RPL13A; RPS11; RPS9; RPL28; RPS5; RPL3
GO:0006605	protein targeting	14.30	0.00e+00	0.00e+00	78/261	RPL22; RPL11; RPS8; RPL5; RPS27; RPS7; RPS27A; RPL31; RPL37A; RPL32; RPL15; RPSA; RPL14; RPL29; RPL24; RPL35A; RPL9; RPL34; RPS3A; RPL37; RPS23; RPS14; RPS18; RPS10; RPL10A; RPS12; SLC25A6; RPS4X; RPL36A; RPL39; RPL10; RPS20; RPL7; RPL30; RPL8; RPS6; RPL35; RPL12; RPL7A; RPLP2; RPL27A; RPS13; RPS3; RPS25; RPS24; RPL41; RPL6; RPLP0; RPL21; RPS29; RPL4; RPLP1; RPS17; RPS2; RPS15A; RPL13; RPL26; RPL23A; RPL23; RPL19; RPL27; RPL38; RPL17; RPS21; RPS15; RPL36; RPS28; RPL18A; UBA52; RPS16; RPS19; RPL18; RPL13A; RPS11; RPS9; RPL28; RPS5; RPL3
GO:0016072	rRNA metabolic process	6.98	3.33e-15	3.06e-13	25/171	RPL11; RPS8; RPL5; RPS27; RPS7; RPSA; RPL14; RPL35A; RPS14; RPL10A; RPL7; RPS6; RPL35; RPL7A; RPS24; RPS17; RPS2; RPL26; RPL27; RPS21; RPS15; RPS28; RPS16; RPS19; RPS9
GO:0022613	ribonucleoprotein complex biogenesis	5.35	0.00e+00	0.00e+00	37/330	RPL11; RPS8; RPL5; RPS27; RPS7; RPSA; RPL14; RPL24; RPL35A; RPS23; RPS14; RPS10; RPL10A; RPL10; RPL7; RPS6; RPL35; RPL12; RPL7A; RPS24; RPL6; RPLP0; RPS17; RPS2; RPL26; RPL23A; RPL27; RPL38; RPS21; RPS15; RPS28; RPS16; RPS19; RPL13A; RPS9; RPS5; RPL3
GO:0034470	ncRNA processing	5.35	1.71e-12	1.39e-10	25/223	RPL11; RPS8; RPL5; RPS27; RPS7; RPSA; RPL14; RPL35A; RPS14; RPL10A; RPL7; RPS6; RPL35; RPL7A; RPS24; RPS17; RPS2; RPL26; RPL27; RPS21; RPS15; RPS28; RPS16; RPS19; RPS9
GO:0071826	ribonucleoprotein complex subunit organization	5.16	7.84e-10	5.76e-08	20/185	RPL11; RPL5; RPS27; RPSA; RPL24; RPS23; RPS14; RPS10; RPL10; RPL12; RPL6; RPLP0; RPL23A; RPL38; RPS15; RPS28; RPS19; RPL13A; RPS5; RPL3
GO:0034248	regulation of cellular amide metabolic process	3.16	6.27e-05	4.18e-03	15/227	RPL5; IGFBP5; RPS14; GNB2L1; SOX4; EEF1A1; RPS4X; RPL10; RPS3; GAPDH; RPL26; RPL38; EEF2; RPL13A; RPS9
GO:0010608	posttranscriptional regulation of gene expression	2.67	2.52e-04	1.54e-02	16/286	RPL5; RPS27A; IGFBP5; RPS14; GNB2L1; SOX4; RPS4X; RPL10; RPS3; GAPDH; RPL26; RPL38; EEF2; UBA52; RPL13A; RPS9

Factor 12 : 5 significant GO terms

GeneSet	description	enrichRatio	pValue	FDR	GeneRatio	geneSymbols
GO:0070972	protein localization to endoplasmic reticulum	12.00	2.71e-08	1.99e-05	9/119	RPL31; RPL37A; RPL37; SEC61G; RPL39; RPLP2; RPS24; RPS2; RPL38
GO:0006413	translational initiation	9.09	3.02e-07	7.40e-05	9/157	RPL31; RPL37A; RPL37; RPL39; RPLP2; RPS24; RPS2; RPL38; EIF2S2
GO:0090150	establishment of protein localization to membrane	7.00	2.78e-06	5.09e-04	9/204	RPL31; RPL37A; RPL37; RPL39; RPLP2; RPS24; HSP90AA1; RPS2; RPL38
GO:0006605	protein targeting	6.69	2.50e-07	7.40e-05	11/261	RPL31; RPL37A; RPL37; SEC61G; RPL39; RPLP2; RPS24; UBC; HSP90AA1; RPS2; RPL38
GO:0006401	RNA catabolic process	6.05	9.24e-06	1.36e-03	9/236	RPL31; RPL37A; RPL37; RPL39; RPLP2; RPS24; UBC; RPS2; RPL38

Factor 15 : 3 significant GO terms

GeneSet	description	enrichRatio	pValue	FDR	GeneRatio	geneSymbols
GO:0015844	monoamine transport	15.40	1.18e-05	0.00868	5/17	GPM6B; SYT7; SNCG; SYT1; SYT4
GO:0015696	ammonium transport	11.40	5.87e-05	0.01437	5/23	GPM6B; SYT7; SNCG; SYT1; SYT4
GO:0007517	muscle organ development	4.84	3.32e-05	0.01219	10/108	TNNI1; CHRNA1; BASP1; NEUROG1; ETV1; G6PD; CNTFR; MYL6; EFNB2; SIX1

Factor 18 : 11 significant GO terms

GeneSet	description	enrichRatio	pValue	FDR	GeneRatio	geneSymbols
GO:0070972	protein localization to endoplasmic reticulum	12.70	0.00e+00	0.00e+00	32/119	RPL22; RPL5; RPS7; RTN4; RPL37A; RPL15; RPSA; RPL14; RPS3A; RPL37; RPL10A; RPS4X; RPL10; RPS20; RPL7; RPL35; RPL7A; RPS3; RPS26; RPL41; RPL6; RPLP0; RPS29; RPL4; RPS2; RPL23; RPL36; RPS28; KDELR1; RPL13A; RPS9; RPL3
GO:0006413	translational initiation	12.30	0.00e+00	0.00e+00	41/157	RPL22; RPL5; RPS7; RPL37A; RPL15; RPSA; EIF1B; RPL14; EIF4A2; RPS3A; RPL37; NPM1; RPL10A; RPS4X; RPL10; RPS20; RPL7; PABPC1; EIF3E; EIF3H; RPL35; RPL7A; EIF3F; EIF3M; RPS3; RPS26; RPL41; RPL6; RPLP0; RPS29; RPL4; RPS2; RPL23; EIF1; RPL36; RPS28; RPL13A; RPS9; EIF3D; EIF3L; RPL3
GO:0002181	cytoplasmic translation	11.70	3.33e-15	4.07e-13	18/73	RPL15; TMA7; RPL10A; EIF3E; EIF3H; EIF3F; EIF3M; RPS26; RPL41; RPL6; RPLP0; RPS29; EEF2; RPL36; RPS28; RPL13A; EIF3D; EIF3L
GO:0006401	RNA catabolic process	7.21	0.00e+00	0.00e+00	36/236	RPL22; YBX1; RPL5; RPS7; RPL37A; RPL15; RPSA; RPL14; RPS3A; RPL37; NPM1; RPL10A; RPS4X; RPL10; RPS20; RPL7; PABPC1; EIF3E; RPL35; RPL7A; RPS3; RPS26; RPL41; RPL6; RPLP0; RPS29; SLIRP; RPL4; RPS2; RPL23; CIRBP; RPL36; RPS28; RPL13A; RPS9; RPL3
GO:0090150	establishment of protein localization to membrane	7.19	0.00e+00	0.00e+00	31/204	RPL22; RPL5; RPS7; RPL37A; RPL15; RPSA; RPL14; RPS3A; RPL37; GNB2L1; RPL10A; RPS4X; RPL10; RPS20; RPL7; RPL35; RPL7A; RPS3; RPS26; RPL41; RPL6; RPLP0; RPS29; RPL4; RPS2; RPL23; RPL36; RPS28; RPL13A; RPS9; RPL3
GO:0006605	protein targeting	5.80	0.00e+00	0.00e+00	32/261	RPL22; RPL5; TOMM20; RPS7; RPL37A; RPL15; RPSA; RPL14; RPS3A; RPL37; RPL10A; SLC25A6; RPS4X; RPL10; RPS20; RPL7; RPL35; RPL7A; RPS3; RPS26; RPL41; RPL6; RPLP0; RPS29; RPL4; RPS2; RPL23; RPL36; RPS28; RPL13A; RPS9; RPL3
GO:0071826	ribonucleoprotein complex subunit organization	4.60	3.90e-08	3.58e-06	18/185	RPL5; RPSA; NPM1; RBMX; RPL10; EIF3E; EIF3H; EIF3F; EIF3M; RPL6; RPLP0; CIRBP; RPS28; GLTSCR2; RPL13A; EIF3D; EIF3L; RPL3
GO:0034248	regulation of cellular amide metabolic process	3.75	8.85e-07	7.22e-05	18/227	RPL5; EIF1B; EIF4A2; NPM1; GNB2L1; EEF1A1; RPS4X; RPL10; PABPC1; EIF3E; EIF3H; RPS3; EIF1; CIRBP; EEF2; RPL13A; RPS9; EIF3D
GO:0022613	ribonucleoprotein complex biogenesis	3.73	2.18e-09	2.29e-07	26/330	RPL5; RPS7; RPSA; RPL14; NPM1; RPL10A; RBMX; RPL10; RPL7; EIF3E; EIF3H; RPL35; RPL7A; EIF3F; EIF3M; RPL6; RPLP0; RPS2; CIRBP; RPS28; GLTSCR2; RPL13A; RPS9; EIF3D; EIF3L; RPL3
GO:0016072	rRNA metabolic process	3.32	2.26e-04	1.51e-02	12/171	RPL5; RPS7; RPSA; RPL14; RPL10A; RPL7; RPL35; RPL7A; RPS2; RPS28; GLTSCR2; RPS9
GO:0010608	posttranscriptional regulation of gene expression	3.31	1.51e-06	1.11e-04	20/286	YBX1; RPL5; H3F3A; EIF1B; EIF4A2; NPM1; GNB2L1; RPS4X; RPL10; PABPC1; EIF3E; EIF3H; POLR2L; RPS3; EIF1; CIRBP; EEF2; RPL13A; RPS9; EIF3D

Factor 20 : 2 significant GO terms

GeneSet	description	enrichRatio	pValue	FDR	GeneRatio	geneSymbols
GO:0008277	regulation of G protein-coupled receptor signaling pathway	7.57	2.99e-05	0.0220	7/45	STMN1; RGS16; RGS2; ATP2B4; ABHD6; RGS10; CALM1
GO:0003012	muscle system process	4.35	8.47e-05	0.0311	10/112	RGS2; ATP2B4; AGT; RYR2; MYL1; NEUROG1; CAMK2B; CALM1; SSTR2; PDE9A

Summary:
Factor	1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	19	20
Signif_GO_terms	7	28	10	40	18	12	19	4	35	0	12	5	0	0	3	0	0	11	0	2

5.1.1 Factors of interest

4, 9, 15

6 Gene Set Enrichment Analysis by Perturbation

Target genes: Genes w/ LFSR < 0.05 under each perturbation marker gene;
Backgroud genes: all 6000 genes used in factor analysis;
Statistical test: hypergeometric test (over-representation test);
Only GO terms/pathways that satisfy fold change \(\geq\) 2 and test FDR \(<\) 0.05 are shown below.

6.1 GO Slim Over-Representation Analysis

Gene sets: Gene ontology "Biological Process" (non-redundant).

6.1.1 Early stage cells

ADNP : 12 significant GO terms

GeneSet	description	enrichRatio	pValue	FDR	GeneRatio	geneSymbols
GO:0007218	neuropeptide signaling pathway	12.10	2.04e-04	0.028393	4/10	GAL; NMB; SSTR2; PTH2
GO:0008277	regulation of G protein-coupled receptor signaling pathway	4.72	5.84e-04	0.038949	7/45	STMN1; RGS16; RGS2; ATP2B4; CNTN2; ABHD6; DNM1
GO:0030534	adult behavior	4.72	5.84e-04	0.038949	7/45	CNTN2; ID2; HDAC2; PBX3; LGI4; SEZ6L; CSTB
GO:0003012	muscle system process	4.34	5.63e-07	0.000413	16/112	RGS2; ATP2B4; AGT; IGFBP5; CAMK2D; SORBS2; COL4A3BP; HDAC2; CAMK2B; MTPN; TPM2; VCL; ACTC1; SSTR2; TNNC2; PDE9A
GO:0003007	heart morphogenesis	4.27	2.13e-04	0.028393	9/64	JUN; ID2; NRP2; ROBO1; IFT57; COL4A3BP; OLFM1; SIX1; ACTC1
GO:0097305	response to alcohol	3.90	4.24e-04	0.034555	9/70	RGS2; EEF1B2; SPARC; HDAC2; LANCL2; TNC; GSTP1; ACTC1; MT-ND4
GO:0050673	epithelial cell proliferation	3.88	4.98e-05	0.012178	12/94	JUN; VASH2; ID2; NRP2; IGFBP5; SCG2; ROBO1; IFT57; SPARC; SIX1; PGF; SERPINF1
GO:0001101	response to acid chemical	3.34	3.95e-04	0.034555	11/100	FABP3; ATP2B4; CASP3; SPARC; HDAC2; LANCL2; TNC; GSTP1; SIX1; SERPINF1; BAIAP2
GO:0090130	tissue migration	3.34	7.33e-04	0.044844	10/91	JUN; AGT; ZEB2; NRP2; SCG2; IQSEC1; ROBO1; SPARC; ACTC1; SERPINF1
GO:0001525	angiogenesis	3.31	2.32e-04	0.028393	12/110	JUN; SHC1; EFNA3; VASH2; AGT; NRP2; SCG2; ROBO1; SPARC; VAV2; PGF; SERPINF1
GO:0061564	axon development	3.08	3.13e-06	0.001149	21/207	STMN1; JUN; S100A6; SHC1; EFNA3; CNTN2; ZEB2; NRP2; ROBO1; SPON2; CASP3; ETV1; TNC; OLFM1; NCAM1; ANK3; VCL; LINGO1; BAIAP2; DCC; ADARB1
GO:0099177	regulation of trans-synaptic signaling	2.80	4.23e-04	0.034555	14/152	PRKCZ; CNTN2; AGT; ABHD6; CPLX1; CPLX2; CAMK2B; DNM1; SYT7; NTF3; RAB26; BAIAP2; CELF4; DCC

ARID1B : 24 significant GO terms

GeneSet	description	enrichRatio	pValue	FDR	GeneRatio	geneSymbols
GO:0010257	NADH dehydrogenase complex assembly	4.83	9.74e-14	2.38e-11	28/60	NDUFS5; NDUFB3; NDUFAF3; NDUFB4; NDUFS6; NDUFA2; NDUFB2; NDUFB11; NDUFA1; NDUFB9; TMEM261; NDUFB6; NDUFA8; NDUFS8; NDUFC2; NDUFB8; NDUFB1; NDUFB10; NDUFAB1; NDUFS7; NDUFA11; NDUFA7; NDUFB7; NDUFA13; NDUFA3; NDUFA6; MT-ND3; MT-ND6
GO:0010644	cell communication by electrical coupling	4.78	7.47e-04	3.05e-02	6/13	ATP1B1; FKBP1B; DBN1; SRI; ANK3; CALM1
GO:0033108	mitochondrial respiratory chain complex assembly	4.17	1.95e-14	7.17e-12	35/87	NDUFS5; COX20; NDUFB3; NDUFAF3; COX17; NDUFB4; NDUFS6; NDUFA2; UQCC2; NDUFB2; NDUFB11; NDUFA1; NDUFB9; TMEM261; NDUFB6; NDUFA8; NDUFS8; NDUFC2; NDUFB8; COX14; NDUFB1; NDUFB10; NDUFAB1; COA3; NDUFS7; NDUFA11; PET100; NDUFA7; NDUFB7; NDUFA13; NDUFA3; UQCR10; NDUFA6; MT-ND3; MT-ND6
GO:1902600	proton transmembrane transport	4.03	4.15e-12	5.30e-10	30/77	PARK7; COX5B; ATP5G3; COX17; ATP5I; COX7C; COX7A2; NDUFA4; ATP5J2; ATP6V1F; ATP6V0E2; TMSB4X; COX7B; COX6C; COX8A; ATP5L; ATP5B; SLC25A3; COX6A1; COX5A; COX4I1; ATP5G1; ATP5H; ATP5A1; ATP5E; NDUFS7; COX6B1; ATP5J; ATP5O; MT-CO1
GO:0099132	ATP hydrolysis coupled cation transmembrane transport	3.56	1.19e-04	6.25e-03	11/32	ATP5G3; ATP6V1F; ATP6V0E2; ATP5L; ATP5B; ATP2B1; ATP5G1; ATP5H; ATP5A1; ATP5E; ATP5O
GO:0031644	regulation of neurological system process	3.11	1.52e-03	4.31e-02	9/30	PRKCZ; AGT; NRXN1; AKAP9; FABP5; CBLN1; EIF4A3; BAIAP2; CELF4
GO:0009141	nucleoside triphosphate metabolic process	3.07	2.22e-15	1.63e-12	56/189	PARK7; ATPIF1; NDUFS5; UQCRH; ATP1B1; COX5B; ATP5G3; NDUFB3; NDUFB4; ATP5I; SNCA; NDUFS6; COX7C; UQCRQ; NDUFA2; UQCC2; COX7A2; NDUFA4; CYCS; ATP5J2; NDUFB2; TMSB4X; NDUFA1; NDUFB9; NDUFB6; NDUFA8; AK1; NDUFS8; NDUFC2; ATP5L; NDUFB8; TPI1; ATP5B; COX6A1; RAN; NDUFB1; COX5A; NDUFB10; NDUFAB1; DCTPP1; COX4I1; ATP5G1; NME1; ATP5H; ATP5A1; ATP5E; NDUFS7; NDUFA7; NDUFB7; NDUFA3; UQCR10; NDUFA6; ATP5J; ATP5O; MT-CO1; MT-ND3
GO:0050663	cytokine secretion	2.88	1.62e-03	4.31e-02	10/36	PRKCZ; S100A13; AGT; SELK; BTN2A2; EZR; TMSB4X; CADM1; HMGB1; MIF
GO:0009123	nucleoside monophosphate metabolic process	2.87	1.65e-13	3.04e-11	54/195	PARK7; ATPIF1; NDUFS5; UQCRH; ATP1B1; COX5B; ATP5G3; NDUFB3; NDUFB4; ATP5I; SNCA; NDUFS6; COX7C; UQCRQ; NDUFA2; UQCC2; COX7A2; HDDC2; NDUFA4; CYCS; ATP5J2; NDUFB2; TMSB4X; NDUFA1; NDUFB9; NDUFB6; NDUFA8; AK1; NDUFS8; NDUFC2; ATP5L; NDUFB8; TPI1; ATP5B; COX6A1; NDUFB1; COX5A; NDUFB10; NDUFAB1; COX4I1; ATP5G1; ATP5H; ATP5A1; ATP5E; NDUFS7; NDUFA7; NDUFB7; NDUFA3; UQCR10; NDUFA6; ATP5J; ATP5O; MT-CO1; MT-ND3
GO:0070972	protein localization to endoplasmic reticulum	2.70	1.47e-07	1.20e-05	31/119	RPL5; RPS27A; RPL15; RPSA; SPCS1; RPL9; RPS3A; RPS12; SEC61G; RPS4X; RPL7; SEC61B; RPL35; RPL12; RPL7A; RPLP2; RPS3; RPS26; RPLP0; SRP14; RPL4; RPS2; RPL13; RPL23A; RPL19; RPS21; RPS19; RPL18; RPL13A; RPL28; RPL3
GO:0035637	multicellular organismal signaling	2.65	1.99e-03	4.88e-02	11/43	ATP1B1; AGT; FKBP1B; SCN3A; SCN9A; SRI; AKAP9; ANK3; ATP2B1; CALM1; SOD1
GO:0007006	mitochondrial membrane organization	2.53	4.52e-05	2.62e-03	21/86	ATPIF1; ATP5G3; ATP5I; SNCA; DYNLT1; ATP5J2; YWHAZ; TIMM10; ATP5L; ATP5B; CALM1; ATP5G1; ATP5H; ATP5A1; ROMO1; ATP5E; TIMM13; NDUFA13; PDCD5; ATP5J; ATP5O
GO:0006091	generation of precursor metabolites and energy	2.50	4.34e-12	5.30e-10	60/248	PARK7; SH3BGRL3; ATPIF1; NDUFS5; UQCRH; COX20; COX5B; NDUFB3; COX17; NDUFB4; ATP5I; SNCA; NDUFS6; COX7C; GLRX; UQCRQ; NDUFA2; UQCC2; COX7A2; NDUFA4; CYCS; ATP5J2; NDUFB2; COX7B; NDUFA1; COX6C; NDUFB9; NDUFB6; NDUFA8; COX8A; NDUFS8; NDUFC2; ATP5L; CISD1; NDUFB8; TPI1; BLOC1S1; ATP5B; COX6A1; HMGB1; NDUFB1; COX5A; NDUFB10; NDUFAB1; COX4I1; ATP5H; ATP5A1; ATP5E; NDUFS7; UQCR11; NDUFA7; NDUFB7; COX6B1; NDUFA3; UQCR10; NDUFA6; ATP5J; ATP5O; MT-CO1; MT-ND3
GO:0010959	regulation of metal ion transport	2.41	4.63e-05	2.62e-03	23/99	SEPN1; ATP1B1; AGT; FKBP1B; GNAI2; SNCA; GLRX; CAMK2B; SRI; AKAP9; SARAF; CHD7; ANK3; KCNIP2; CD63; JPH4; AKAP6; CALM1; B2M; NKAIN4; HOMER3; FXYD7; ATF4
GO:0009259	ribonucleotide metabolic process	2.38	6.85e-11	7.18e-09	59/257	PARK7; ATPIF1; NDUFS5; UQCRH; ATP1B1; COX5B; DBI; ATP5G3; NDUFB3; NDUFB4; ATP5I; SCD5; SNCA; NDUFS6; COX7C; HINT1; UQCRQ; NDUFA2; UQCC2; COX7A2; NDUFA4; CYCS; ATP5J2; NDUFB2; TMSB4X; NDUFA1; NDUFB9; NDUFB6; NDUFA8; AK1; NDUFS8; NDUFC2; ATP5L; NDUFB8; TPI1; ATP5B; COX6A1; RAN; NDUFB1; COX5A; NDUFB10; NDUFAB1; COX4I1; ATP5G1; NME1; ATP5H; ATP5A1; ATP5E; NDUFS7; NDUFA7; NDUFB7; NDUFA3; UQCR10; NDUFA6; ATP5J; ATP5O; PDE9A; MT-CO1; MT-ND3
GO:0006413	translational initiation	2.31	1.37e-06	1.01e-04	35/157	RPL5; RPS27A; RPL15; RPSA; EIF1B; EIF4A2; RPL9; RPS3A; RPS12; RPS4X; RPL7; EIF3E; EIF3H; RPL35; RPL12; RPL7A; RPLP2; EIF3F; RPS3; RPS26; RPLP0; EIF3J; RPL4; RPS2; RPL13; RPL23A; RPL19; RPS21; RPS19; RPL18; RPL13A; RPL28; EIF3L; RPL3; ATF4
GO:0043270	positive regulation of ion transport	2.28	1.70e-03	4.31e-02	15/68	PARK7; ATP1B1; AGT; COX17; SNCA; GLRX; SRI; AKAP9; TMSB4X; ANK3; KCNIP2; AKAP6; CALM1; MIF; ATF4
GO:0090150	establishment of protein localization to membrane	2.28	5.50e-08	5.05e-06	45/204	RPL5; ATP1B1; RPS27A; REEP1; RPL15; RPSA; NSG1; RPL9; RPS3A; GNB2L1; CD24; RPS12; FIS1; RPS4X; RPL7; YWHAZ; SEC61B; RPL35; RPL12; RPL7A; RPLP2; TIMM10; RPS3; ANK3; RPS26; RPLP0; CALM1; SRP14; RPL4; RPS2; RAB26; RPL13; RPL23A; RPL19; RAB31; ROMO1; RPS21; TIMM13; NDUFA13; PDCD5; RPS19; RPL18; RPL13A; RPL28; RPL3
GO:0032409	regulation of transporter activity	2.17	1.53e-03	4.31e-02	17/81	PARK7; SEPN1; ATP1B1; FKBP1B; COX17; SNCA; GLRX; ACTB; SRI; AKAP9; TMSB4X; ANK3; KCNIP2; JPH4; AKAP6; CALM1; FXYD7
GO:0072593	reactive oxygen species metabolic process	2.17	1.16e-03	4.07e-02	18/86	PARK7; ATPIF1; PRDX1; GADD45A; AGT; GPX1; GNAI2; SNCA; HSP90AB1; PRDX5; GSTP1; SH3PXD2A; MAPT; ROMO1; PREX1; PRDX2; NDUFA13; SOD1
GO:0019932	second-messenger-mediated signaling	2.14	1.02e-03	3.73e-02	19/92	SEPN1; ATP1B1; AGT; FKBP1B; NEUROD1; GNAI2; SELK; HINT1; SRI; FIS1; NRG1; PEBP1; JPH4; AKAP6; CALM1; MAPT; HOMER3; APLP1; PDE9A
GO:0072507	divalent inorganic cation homeostasis	2.11	6.71e-04	2.90e-02	21/103	SEPN1; ATP1B1; AGT; FKBP1B; SELK; SNCA; CD24; SRI; FIS1; CHD7; ANK3; DDIT3; ATP2B1; HSP90B1; HMGB1; TPT1; JPH4; AKAP6; CALM1; CACNA1A; ATF4
GO:0052547	regulation of peptidase activity	2.05	3.29e-04	1.51e-02	25/126	PARK7; NRDC; LAMTOR5; AGT; HSPE1; GPX1; SNCA; GNB2L1; CYCS; HIP1; FIS1; PCSK1N; NGFRAP1; ANP32B; PRDX5; RPS3; PEBP1; HMGB1; MAPT; NGFR; TIMP2; CST3; NDUFA13; PDCD5; CSTB
GO:0051235	maintenance of location	2.01	1.28e-03	4.27e-02	21/108	PARK7; SEPN1; HNRNPU; FKBP1B; TMSB10; SNCA; SKP1; DBN1; MDFI; EZR; SRI; AKAP9; TMSB4X; CHD7; TXN; ANK3; DDIT3; HSP90B1; JPH4; AKAP6; CALM1

CHD2 : 13 significant GO terms

GeneSet	description	enrichRatio	pValue	FDR	GeneRatio	geneSymbols
GO:0070972	protein localization to endoplasmic reticulum	8.32	0.00e+00	0.00e+00	58/119	RPL22; RPL11; RPS8; RPL5; RPS27; RPS27A; RPL31; RPL37A; RPL32; RPL15; RPSA; RPL14; RPL24; RPL35A; RPL9; RPL34; RPS3A; RPS23; RPS14; RPS10; RPS12; RPS4X; RPL39; RPL10; RPL7; RPL30; RPS6; RPL35; HSPA5; RPL7A; RPL27A; RPS13; RPS3; RPS24; RPL41; RPL6; RPLP0; RPL21; RPS29; RPL4; RPLP1; RPS17; RPS15A; RPL13; RPL26; RPL23A; RPL19; RPL27; RPL38; RPL17; RPS15; RPS28; RPL18A; RPS16; RPS19; RPL18; RPL13A; RPL3
GO:0006413	translational initiation	6.85	0.00e+00	0.00e+00	63/157	RPL22; RPL11; RPS8; RPL5; RPS27; RPS27A; RPL31; RPL37A; RPL32; RPL15; RPSA; EIF1B; RPL14; RPL24; RPL35A; RPL9; EIF4E; RPL34; RPS3A; RPS23; RPS14; RPS10; RPS12; RPS4X; RPL39; RPL10; COPS5; RPL7; RPL30; EIF3E; RPS6; RPL35; RPL7A; RPL27A; RPS13; RPS3; RPS24; RPL41; RPL6; RPLP0; RPL21; RPS29; RPL4; RPLP1; RPS17; RPS15A; RPL13; EIF4A1; RPL26; RPL23A; RPL19; RPL27; RPL38; RPL17; RPS15; RPS28; RPL18A; RPS16; RPS19; RPL18; RPL13A; RPL3; ATF4
GO:0002181	cytoplasmic translation	5.85	1.02e-13	1.24e-11	25/73	RPL11; RPL31; RPL32; RPL15; TMA7; RPL24; RPL35A; RPL9; RPS23; RPL39; RPL30; EIF3E; RPL41; RPL6; RPLP0; RPS29; RPLP1; RPL26; RPL19; RPL38; RPL17; RPS28; RPL18A; RPL18; RPL13A
GO:0090150	establishment of protein localization to membrane	4.94	0.00e+00	0.00e+00	59/204	RPL22; RPL11; RPS8; RPL5; RPS27; RPS27A; RPL31; RPL37A; RPL32; RPL15; RPSA; RPL14; RPL24; RPL35A; RPL9; RPL34; RPS3A; RPS23; RPS14; RPS10; RPS12; RPS4X; RPL39; RPL10; RPL7; RPL30; RPS6; RPL35; RPL7A; RPL27A; RPS13; RPS3; RPS24; RPL41; RPL6; RPLP0; RPL21; RPS29; CALM1; RPL4; RPLP1; RPS17; RPS15A; RPL13; VAMP2; RPL26; RPL23A; RPL19; RPL27; RPL38; RPL17; RPS15; RPS28; RPL18A; RPS16; RPS19; RPL18; RPL13A; RPL3
GO:0006401	RNA catabolic process	4.34	0.00e+00	0.00e+00	60/236	RPL22; RPL11; RPS8; RPL5; RPS27; RPS27A; RPL31; RPL37A; RPL32; RPL15; RPSA; RPL14; PCBP4; RPL24; RPL35A; RPL9; RPL34; RPS3A; RPS23; RPS14; RPS10; RPS12; RPS4X; RPL39; RPL10; RPL7; RPL30; EIF3E; RPS6; RPL35; RPL7A; RPL27A; RPS13; RPS3; RPS24; RPL41; RPL6; RPLP0; RPL21; RPS29; SLIRP; RPL4; RPLP1; RPS17; RPS15A; RPL13; RPL26; RPL23A; RPL19; RPL27; RPL38; RPL17; RPS15; RPS28; RPL18A; RPS16; RPS19; RPL18; RPL13A; RPL3
GO:0006605	protein targeting	3.93	0.00e+00	0.00e+00	60/261	RPL22; PEX14; RPL11; RPS8; RPL5; RPS27; RPS27A; RPL31; RPL37A; RPL32; RPL15; RPSA; RPL14; RPL24; PARL; RPL35A; RPL9; RPL34; RPS3A; RPS23; RPS14; RPS10; RPS12; AKAP12; RPS4X; RPL39; RPL10; RPL7; RPL30; RPS6; RPL35; RPL7A; RPL27A; RPS13; RPS3; RPS24; RPL41; RPL6; RPLP0; RPL21; RPS29; RPL4; RPLP1; RPS17; RPS15A; RPL13; RPL26; RPL23A; RPL19; RPL27; RPL38; RPL17; RPS15; RPS28; RPL18A; RPS16; RPS19; RPL18; RPL13A; RPL3
GO:0010959	regulation of metal ion transport	3.10	1.28e-05	1.05e-03	18/99	SEPN1; AGT; GNAI2; SNCA; CAMK2B; AKAP9; CHD7; GAL; KCNIP2; CD63; JPH4; CALM1; B2M; VAMP2; NEDD4L; NKAIN4; FXYD7; ATF4
GO:0034765	regulation of ion transmembrane transport	2.77	3.91e-05	2.87e-03	19/117	EPHB2; SEPN1; RGS2; AGT; SCN3A; CRBN; SNCA; AKAP9; TMSB4X; CHD7; GAL; KCNIP2; CD63; JPH4; CALM1; VAMP2; NEDD4L; CACNA1A; FXYD7
GO:0016072	rRNA metabolic process	2.60	5.05e-06	5.01e-04	26/171	RPL11; RPS8; RPL5; RPS27; RPSA; RPL14; RPL35A; RPS14; RPL7L1; CHD7; RPL7; RPS6; RPL35; RPL7A; RPS24; RPS17; RSL1D1; NOB1; RPL26; ZNHIT3; RPL27; RPS15; RPS28; RPS16; RPS19; GLTSCR2
GO:0010038	response to metal ion	2.40	8.73e-04	4.58e-02	16/114	PEF1; S100A13; ID2; SNCA; HSPA5; SYT7; KCNIP2; CALM1; B2M; SERPINF1; NEDD4L; BSG; JUNB; CALR; ATF4; MT-CO1
GO:0099177	regulation of trans-synaptic signaling	2.25	4.83e-04	2.83e-02	20/152	PRKCZ; EPHB2; AGT; GNAI2; SNCA; EIF4E; CPLX2; GRM4; AKAP12; CAMK2B; AKAP9; SYT7; NTF3; JPH4; CALM1; CBLN1; VAMP2; BAIAP2; CELF4; CACNA1A
GO:0071826	ribonucleoprotein complex subunit organization	2.22	1.65e-04	1.10e-02	24/185	RPL11; RPL5; RPS27; RPSA; RPL24; RPS23; RPS14; MRPL22; RPS10; RPL10; EIF3E; STRAP; RPL6; RPLP0; RPL23A; ZNHIT3; RPL38; CELF4; RPS15; RPS28; RPS19; GLTSCR2; RPL13A; RPL3
GO:0022613	ribonucleoprotein complex biogenesis	2.07	5.46e-06	5.01e-04	40/330	RPL11; RPS8; RPL5; RPS27; RPSA; RPL14; RPL24; RPL35A; RPS23; RPS14; MRPL22; RPS10; RPL7L1; RPL10; CHD7; RPL7; EIF3E; RPS6; RPL35; RPL7A; RPS24; STRAP; RPL6; RPLP0; RPS17; RSL1D1; NOB1; RPL26; RPL23A; ZNHIT3; RPL27; RPL38; CELF4; RPS15; RPS28; RPS16; RPS19; GLTSCR2; RPL13A; RPL3

DYRK1A : 9 significant GO terms

GeneSet	description	enrichRatio	pValue	FDR	GeneRatio	geneSymbols
GO:0051131	chaperone-mediated protein complex assembly	12.50	1.93e-04	0.017703	4/11	HSPD1; HSP90AB1; CCT2; HSP90AA1
GO:0070670	response to interleukin-4	12.50	1.93e-04	0.017703	4/11	HSP90AB1; HSPA5; TUBA1B; XBP1
GO:0071897	DNA biosynthetic process	4.50	2.57e-05	0.008269	11/84	CENPF; HNRNPD; HSP90AB1; HNRNPA2B1; PPIA; DKC1; UBE2L6; HNRNPA1; CCT2; HNRNPC; HSP90AA1
GO:0006457	protein folding	4.24	3.49e-07	0.000256	17/138	PDIA6; FKBP1B; HSPD1; HSPE1; CANX; HSP90AB1; PPIA; PRDX4; HSPA5; HSPA8; PFDN5; CCT2; HSP90B1; HSP90AA1; PDIA3; PPIB; CALR
GO:0032200	telomere organization	4.18	2.55e-04	0.020819	9/74	GNL3; HNRNPD; HSP90AB1; HNRNPA2B1; DKC1; HNRNPA1; CCT2; HNRNPC; HSP90AA1
GO:0006403	RNA localization	3.31	3.85e-05	0.008269	15/156	SFPQ; SRSF7; SSB; HNRNPA3; NOP58; NPM1; SRSF3; HNRNPA2B1; DKC1; HNRNPA1; PA2G4; CCT2; RAN; SRSF2; FBL
GO:1903311	regulation of mRNA metabolic process	3.11	4.51e-05	0.008269	16/177	SERBP1; PRDX6; SRSF7; PCBP4; HNRNPD; NPM1; SRSF3; HNRNPA2B1; PABPC1; HSPA8; HNRNPA1; HNRNPC; RBM25; C1QBP; SRSF2; HNRNPM
GO:0006401	RNA catabolic process	2.62	1.40e-04	0.017109	18/236	SERBP1; SSB; PCBP4; HNRNPD; RPL37; NPM1; RPS4X; RPL39; RPL10; DKC1; PABPC1; RPS13; HSPA8; HNRNPC; HNRNPM; C19orf43; RPS9; RPL28
GO:0010608	posttranscriptional regulation of gene expression	2.53	6.48e-05	0.009508	21/286	SERBP1; EPRS; EIF5B; NCL; PCBP4; HNRNPD; NPM1; SOX4; HNRNPA2B1; RPS4X; RPL10; DKC1; PABPC1; HSPA8; PA2G4; RAN; HNRNPC; C1QBP; HNRNPM; CALR; RPS9

PTEN : 12 significant GO terms

GeneSet	description	enrichRatio	pValue	FDR	GeneRatio	geneSymbols
GO:0006414	translational elongation	3.41	1.11e-15	2.72e-13	47/109	AURKAIP1; MRPS15; MRPL37; MRPL9; MRPS5; MRPS9; MRPL44; MRPS22; MRPL47; MRPS18C; MRPS30; MRPL22; GNB2L1; MRPS18B; MRPS10; MRPL2; MRPS18A; EEF1A1; MRPL18; MRPL32; MRPL13; MRPL50; MRPS2; RPLP2; MRPL21; MRPL51; MRPS35; MRPL42; MRPL52; MRPL46; MRPS11; MRPL28; MRPS34; EIF5A; ERAL1; MRPL10; MRPL27; MRPS23; ICT1; MRPS7; MRPL12; MRPS26; EEF2; GADD45GIP1; MRPL40; MRPL39; MRPS6
GO:0070972	protein localization to endoplasmic reticulum	3.33	4.44e-16	1.63e-13	50/119	RPS8; RPL5; RPS27; RPS7; RPL31; RPL32; RPL15; RPL14; RPL29; RPL24; SEC62; RPL35A; SRP72; RPL34; ANK2; RPS23; RPS14; RPS18; RPL10A; RPS4X; RPL36A; RPL39; RPL10; RPS20; RPL7; RPL30; RPL12; RPL7A; RPLP2; SPCS2; RPS3; RPS25; RPS24; RPS26; RPL6; RPLP0; RPS27L; RPL4; RPS2; RPS15A; RPL26; RPL23; RPS21; ASNA1; KDELR1; RPL18; RPS11; RPS9; RPL28; RPS5; RPL3
GO:0140053	mitochondrial gene expression	3.14	9.36e-14	1.72e-11	46/116	AURKAIP1; MRPS15; MRPL37; MRPL9; MRPS5; MRPS9; MRPL44; MRPS22; MRPL47; MRPS18C; MRPS30; MRPL22; MRPS18B; MRPS10; MRPL2; MRPS18A; MRPL18; MALSU1; MRPL32; TBRG4; HSD17B10; MRPL13; MRPL50; MRPS2; MRPL21; MRPL51; MRPS35; MRPL42; MRPL52; MRPL46; MRPS11; MRPL28; MRPS34; ERAL1; MRPL10; MRPL27; MRPS23; ICT1; MRPS7; MRPL12; MRPS26; UQCC1; GADD45GIP1; MRPL40; MRPL39; MRPS6
GO:0006413	translational initiation	3.13	0.00e+00	0.00e+00	62/157	EIF3I; RPS8; RPL5; RPS27; RPS7; DDX1; RPL31; RPL32; RPL15; RPL14; RPL29; RPL24; EIF4A2; RPL35A; EIF4E; RPL34; RPS23; RPS14; RPS18; RPL10A; HSPB1; RPS4X; RPL36A; RPL39; RPL10; EIF4EBP1; RPS20; COPS5; RPL7; RPL30; PABPC1; RPL12; RPL7A; RPLP2; EIF3F; POLR2G; PPP1CA; RPS3; RPS25; CDC123; RPS24; RPS26; RPL6; RPLP0; EIF5; EIF3J; RPS27L; RPL4; RPS2; RPS15A; EIF4A1; RPL26; RPL23; EIF6; RPS21; RPL18; RPS11; RPS9; RPL28; RPS5; EIF3L; RPL3; ATF4
GO:0010257	NADH dehydrogenase complex assembly	3.04	3.50e-07	2.33e-05	23/60	NDUFS2; NDUFB4; NDUFB5; NDUFC1; NDUFS6; NDUFS4; NDUFA5; NDUFB11; NDUFB9; NDUFA8; NDUFS3; NDUFV1; NDUFS8; NDUFC2; TMEM126B; NDUFA9; NDUFA12; NDUFAB1; NDUFV2; NDUFS7; NDUFA13; NDUFA6; MT-ND4
GO:0002181	cytoplasmic translation	2.71	1.31e-06	7.41e-05	25/73	EIF3I; RPL31; RPL32; RPL15; TMA7; RPL29; RPL24; RPL35A; RPS23; RPL10A; RPL36A; RPL39; EIF4EBP1; RPL30; EIF3F; RPS26; RPL6; RPLP0; EIF5; EIF3J; RPL26; RPS21; EEF2; RPL18; EIF3L
GO:0090150	establishment of protein localization to membrane	2.37	1.91e-11	2.80e-09	61/204	HPCA; RPS8; RPL5; RPS27; RPS7; RPL31; C2orf47; RPL32; RPL15; RPL14; RPL29; RPL24; SEC62; RPL35A; SRP72; RPL34; RPS23; RPS14; GNB2L1; RPS18; RPL10A; CD24; GOPC; RPS4X; RPL36A; RPL39; RPL10; RPS20; RPL7; RPL30; RPL12; RPL7A; RPLP2; BAD; RPS3; RPS25; RPS24; RPS26; RPL6; RPLP0; CALM1; RPS27L; RPL4; RPS2; RPS15A; VPS35; TIMM22; VAMP2; RPL26; RPL23; NMT1; RPS21; ASNA1; RAB8A; NDUFA13; PDCD5; RPL18; RPS11; RPS9; RPL28; RPS5; RPL3
GO:0033108	mitochondrial respiratory chain complex assembly	2.18	1.24e-04	5.07e-03	24/87	NDUFS2; NDUFB4; NDUFB5; NDUFC1; NDUFS6; NDUFS4; NDUFA5; NDUFB11; NDUFB9; NDUFA8; NDUFS3; NDUFV1; NDUFS8; NDUFC2; TMEM126B; NDUFA9; NDUFA12; NDUFAB1; NDUFV2; UQCC1; NDUFS7; NDUFA13; NDUFA6; MT-ND4
GO:0016072	rRNA metabolic process	2.18	8.45e-08	6.89e-06	47/171	RPS8; RPF1; RPL5; RPS27; RPS7; WDR43; MRPS9; NIFK; RPL14; EXOSC7; RRP9; RPL35A; RPS14; ABT1; RPL10A; BYSL; RPL7L1; GTF3C6; DDX56; CHD7; RPL7; DCAF13; EXOSC4; RPL7A; WDR74; TRMT112; GTPBP4; RPS24; EXOSC1; NPM3; EXOSC8; NGDN; NOP10; RPS27L; MRPS11; RPS2; RSL1D1; NOB1; RPL26; DDX52; MAPT; UTP18; RPS21; C19orf43; GLTSCR2; RPS9; RRP1B; RRP1
GO:0006605	protein targeting	2.12	1.49e-10	1.82e-08	70/261	PEX14; HMGCL; ATPIF1; HPCA; RPS8; RPL5; RPS27; TIMM17A; RPS7; RPL31; RPL32; RPL15; RPL14; RPL29; RPL24; SEC62; PARL; RPL35A; SRP72; SCARB2; RPL34; RPS23; RPS14; RPS18; RPL10A; AKAP12; TOMM7; PMPCB; SLC25A6; TIMM17B; RPS4X; RPL36A; RPL39; RPL10; RPS20; RPL7; RPL30; RPL12; RPL7A; PMPCA; RPLP2; AIP; SPCS2; RPS3; RPS25; RPS24; RPS26; RPL6; RPLP0; DNAJC15; RPS27L; RPL4; RPS2; RPS15A; TIMM22; RPL26; RPL23; RPS21; TIMM44; ASNA1; NDUFA13; PDCD5; ECH1; TIMM50; RPL18; RPS11; RPS9; RPL28; RPS5; UBE2L3; RPL3
GO:0009141	nucleoside triphosphate metabolic process	2.10	1.22e-07	8.95e-06	50/189	ATPIF1; NDUFS2; PARP1; GUK1; DGUOK; SUCLG1; COX5B; ATP5G3; DTYMK; NDUFB4; NDUFB5; ATP5I; SNCA; NDUFC1; SDHA; NDUFS6; NDUFS4; UQCRQ; PMPCB; NDUFA5; TMSB4X; NDUFB9; CYC1; NDUFA8; NDUFS3; BAD; NDUFV1; NDUFS8; NDUFC2; SDHD; NDUFA9; ATP5B; NDUFA12; COX6A1; DNAJC15; COX5A; NDUFAB1; COQ9; NCOR1; ATP5G1; NDUFV2; ITPA; EIF6; NDUFS7; SIRT6; UQCRFS1; NDUFA6; ATP5O; MT-CO3; MT-ND4
GO:0006401	RNA catabolic process	2.08	4.49e-09	4.71e-07	62/236	PPP1R8; RPS8; MAGOH; RPL5; RBM8A; RPS27; RPS7; RPL31; RPL32; LSM3; RPL15; RPL14; EXOSC7; PCBP4; RPL29; RPL24; RPL35A; RPL34; RPS23; RPS14; RPS18; RPL10A; TBRG4; HSPB1; RPS4X; RPL36A; RPL39; UPF3B; RPL10; RPS20; RPL7; RPL30; PABPC1; EXOSC4; RPL12; RPL7A; RPLP2; POLR2G; RPS3; RPS25; RPS24; EXOSC1; RPS26; RPL6; RPLP0; EXOSC8; SLIRP; RPS27L; RPL4; RPS2; RNPS1; RPS15A; RPL26; RPL23; RPS21; HNRNPM; C19orf43; RPL18; RPS11; RPS9; RPL28; RPS5; RPL3

Summary:
Marker	ADNP	ARID1B	CHD2	DYRK1A	PTEN
Signif_GO_terms	12	24	13	9	12

6.1.2 Late stage cells

ADNP : 69 significant GO terms

GeneSet	description	enrichRatio	pValue	FDR	GeneRatio	geneSymbols
GO:0007218	neuropeptide signaling pathway	6.59	4.47e-04	1.03e-02	5/10	PCSK1N; GAL; NMB; SSTR2; PTH2
GO:0010644	cell communication by electrical coupling	6.09	1.98e-04	6.55e-03	6/13	ATP1B1; RYR2; FKBP1B; CAMK2D; SRI; ANK3
GO:0002448	mast cell mediated immunity	5.27	4.73e-03	4.88e-02	4/10	S100A13; SPON2; CPLX2; VAMP2
GO:0014075	response to amine	5.27	4.73e-03	4.88e-02	4/10	RGS2; HDAC2; RGS10; ASIC1
GO:0045576	mast cell activation	5.27	4.73e-03	4.88e-02	4/10	S100A13; CPLX2; VAMP2; PVRL2
GO:0031016	pancreas development	3.96	2.84e-03	3.72e-02	6/20	WLS; NEUROD1; CTNNB1; SOX4; ONECUT2; XBP1
GO:0021953	central nervous system neuron differentiation	3.91	1.26e-06	2.03e-04	16/54	LMO4; CNTN2; ZEB2; MAP2; CTNNB1; ROBO1; SOX4; MDGA1; FZD1; MTPN; MYCBP2; POU4F1; HSP90AA1; CBLN1; MAPT; ADARB1
GO:0014074	response to purine-containing compound	3.72	9.92e-05	4.05e-03	11/39	SEPN1; JUN; RYR2; IGFBP5; SPARC; HDAC2; EZR; AKAP9; HSPA5; HSP90B1; BSG
GO:0035637	multicellular organismal signaling	3.68	5.37e-05	2.47e-03	12/43	ATP1B1; AGT; RYR2; FKBP1B; SCN3A; SCN9A; CHRNA1; ANK2; CAMK2D; SRI; AKAP9; ANK3
GO:0048678	response to axon injury	3.64	1.05e-03	1.80e-02	8/29	PTPRF; JUN; FKBP1B; GAP43; NREP; NEFL; TNC; RTN4R
GO:0098742	cell-cell adhesion via plasma-membrane adhesion molecules	3.63	1.28e-04	4.93e-03	11/40	PTPRF; CNTN2; PTPRG; ROBO1; ALCAM; MDGA1; CADM1; PCDH17; CBLN1; BSG; PVRL2
GO:0030865	cortical cytoskeleton organization	3.60	4.80e-03	4.88e-02	6/22	EPB41; RAB13; WDR1; EZR; EPB41L3; CALR
GO:0003007	heart morphogenesis	3.50	3.17e-06	3.88e-04	17/64	JUN; GNG5; RYR2; ID2; CTNNB1; ROBO1; IFT57; COL4A3BP; SOX4; FZD1; NRG1; CHD7; OLFM1; POU4F1; SIX1; ACTC1; TEAD2
GO:0031099	regeneration	3.47	1.37e-05	9.54e-04	15/57	SEPN1; PTPRF; JUN; FKBP1B; GPX1; GAP43; NREP; MTPN; NEFL; TNC; GSTP1; PGF; PKM; ENO3; RTN4R
GO:0010959	regulation of metal ion transport	3.33	4.41e-08	1.08e-05	25/99	SEPN1; ATP1B1; AGT; RYR2; FKBP1B; CTNNB1; GNAI2; SNCA; ANK2; CAMK2D; GLRX; CAMK2B; SRI; AKAP9; CHD7; GAL; FXYD6; ANK3; KCNIP2; CD63; JPH4; B2M; VAMP2; NKAIN4; FXYD7
GO:0003012	muscle system process	3.30	8.44e-09	3.10e-06	28/112	ENO1; LMNA; ATP1B1; RGS2; AGT; RYR2; FKBP1B; CHRNA1; MYL1; IGFBP5; ANK2; CAMK2D; SORBS2; COL4A3BP; HDAC2; CAMK2B; SRI; CALD1; MTPN; TPM2; VCL; KCNIP2; ACTC1; SSTR2; MYL12A; MYL12B; TNNC2; PDE9A
GO:0030534	adult behavior	3.22	3.97e-04	9.49e-03	11/45	CNTN2; ID2; SNCA; HDAC2; CHD7; PBX3; PCDH17; EFNB3; LGI4; SEZ6L; CSTB
GO:2001023	regulation of response to drug	3.18	4.93e-03	4.88e-02	7/29	RGS2; AGT; NCOA1; SNCA; TXN; SYT7; GAL
GO:0046683	response to organophosphorus	3.10	3.19e-03	3.90e-02	8/34	JUN; IGFBP5; SPARC; EZR; AKAP9; HSPA5; HSP90B1; BSG
GO:0045165	cell fate commitment	3.09	5.93e-04	1.21e-02	11/47	LMO4; ID2; NEUROD1; CTNNB1; GAP43; CASP3; EBF2; NRG1; POU4F1; SIX1; ONECUT2
GO:0007626	locomotory behavior	2.98	1.64e-04	5.73e-03	14/62	CNTN2; ID2; SNCA; SOBP; NRG1; CHD7; PBX3; ZNF385A; NOVA1; EFNB3; SNAP25; LGI4; SEZ6L; CSTB
GO:0002576	platelet degranulation	2.93	4.65e-03	4.88e-02	8/36	TAGLN2; TUBA4A; MANF; WDR1; SPARC; VCL; CD63; LGALS3BP
GO:0008037	cell recognition	2.93	4.65e-03	4.88e-02	8/36	CNTN2; ROBO1; GAP43; CASP3; CCT5; CADM1; EFNB3; BSG
GO:0045454	cell redox homeostasis	2.89	2.98e-03	3.84e-02	9/41	SH3BGRL3; PRDX1; PDIA6; GPX1; GLRX; PRDX4; TXN; PDIA3; NXN
GO:0009914	hormone transport	2.85	2.25e-05	1.38e-03	19/88	MPC2; AGT; FKBP1B; NEUROD1; CAPN10; CPLX1; SOX4; UQCC2; SRI; CHD7; SYT7; GAL; DYNLL1; NMB; DOC2B; VAMP2; SNAP25; CACNA1A; SELM
GO:0034765	regulation of ion transmembrane transport	2.82	1.39e-06	2.03e-04	25/117	SEPN1; ATP1B1; RGS2; AGT; RYR2; FKBP1B; SCN3A; SCN9A; WDR1; SNCA; ANK2; CAMK2D; GLRX; SRI; AKAP9; CHD7; GAL; FXYD6; ANK3; KCNIP2; CD63; JPH4; VAMP2; CACNA1A; FXYD7
GO:0003205	cardiac chamber development	2.81	2.27e-03	3.21e-02	10/47	LMO4; RYR2; ID2; ROBO1; ANK2; SOX4; FZD1; NRG1; CHD7; POU4F1
GO:0060541	respiratory system development	2.81	2.27e-03	3.21e-02	10/47	SEPN1; IGFBP5; CTNNB1; SPARC; CHD7; TNC; PPP1CA; SIX1; RAB3A; GNG8
GO:0061564	axon development	2.80	1.24e-10	9.08e-08	44/207	STMN1; PTPRF; JUN; S100A6; SHC1; EFNA3; CRABP2; LHX9; CNTN2; FKBP1B; ZEB2; MAP2; TWF2; ROBO1; ALCAM; GAP43; SPON2; CASP3; MAP1B; NREP; EZR; ETV1; NEFM; NEFL; DPYSL2; TNC; SPTAN1; OLFM1; NCAM1; FEZ1; ANK3; VCL; MYCBP2; POU4F1; HSP90AA1; LINGO1; EFNB3; MAPT; NGFR; BAIAP2; BSG; RAB3A; RTN4R; ADARB1
GO:0032409	regulation of transporter activity	2.77	8.88e-05	3.83e-03	17/81	SEPN1; ATP1B1; RYR2; FKBP1B; SNCA; ANK2; CAMK2D; GLRX; SRI; AKAP9; GAL; FXYD6; ANK3; KCNIP2; JPH4; VAMP2; FXYD7
GO:0030902	hindbrain development	2.73	1.10e-03	1.84e-02	12/58	RERE; WLS; NEUROD1; CTNNB1; MTPN; HSPA5; POU4F1; CBLN1; SSTR2; SEZ6L; MT-CO1; MT-ND4
GO:0007517	muscle organ development	2.69	1.37e-05	9.54e-04	22/108	SEPN1; RGS2; RYR2; ZBTB18; CHRNA1; DNER; CTNNB1; GPX1; FAM65B; UQCC2; ETV1; SRI; FZD1; MTPN; NRG1; CHD7; POU4F1; SIX1; ACTC1; TCF12; XBP1; ADARB1
GO:0042391	regulation of membrane potential	2.64	7.70e-06	7.06e-04	24/120	PRKCZ; JUN; ATP1B1; RYR2; FKBP1B; SCN3A; SCN9A; CHRNA1; WDR1; SNCA; ANK2; CAMK2D; GLRX; SRI; AKAP9; ANK3; KCNIP2; ASIC1; CBLN1; MAPT; EIF4A3; BAIAP2; CELF4; CACNA1A
GO:0009410	response to xenobiotic stimulus	2.64	4.01e-04	9.49e-03	15/75	SEPN1; PHGDH; RGS2; EPHX1; RYR2; GPX1; SNCA; HDAC2; EIF4EBP1; FBXO32; HSPA5; GSTP1; RGS10; ASIC1; SERPINF1
GO:0043062	extracellular structure organization	2.64	1.51e-03	2.41e-02	12/60	MFAP2; AGT; CD47; SPARC; GPM6B; PRDX4; TNC; ITGAE; MFAP4; CST3; PLTP; BSG
GO:0006814	sodium ion transport	2.64	2.35e-03	3.26e-02	11/55	ATP1B1; SCN3A; SCN9A; CAMK2D; GLRX; SLC17A6; FXYD6; ANK3; ASIC1; NKAIN4; FXYD7
GO:0015850	organic hydroxy compound transport	2.59	4.27e-03	4.82e-02	10/51	AGT; NCOA1; MFSD10; SNCA; GPM6B; SYT7; GAL; LIMA1; PLTP; SELM
GO:0060537	muscle tissue development	2.54	3.33e-05	1.88e-03	22/114	SEPN1; LMNA; RGS2; AGT; RYR2; ZBTB18; ID2; CHRNA1; IGFBP5; DNER; CTNNB1; GPX1; SORBS2; FAM65B; UQCC2; MTPN; NRG1; CHD7; POU4F1; SIX1; ACTC1; CALR
GO:0060560	developmental growth involved in morphogenesis	2.52	2.98e-04	7.81e-03	17/89	PRKCZ; CRABP2; ZEB2; MAP2; CTNNB1; TWF2; ALCAM; MAP1B; DPYSL2; TNC; OLFM1; GAL; VCL; SIX1; HSP90AA1; MAPT; RTN4R
GO:0090130	tissue migration	2.46	3.92e-04	9.49e-03	17/91	JUN; RAB13; AGT; ZEB2; SCG2; IQSEC1; GPX1; PTPRG; ROBO1; SPARC; GLIPR2; ATP5B; CORO1C; ACTC1; SERPINF1; MAPRE2; CALR
GO:0051235	maintenance of location	2.44	1.39e-04	5.09e-03	20/108	SEPN1; RYR2; FKBP1B; TWF2; SNCA; ANK2; CAMK2D; MDFI; EZR; SRI; AKAP9; CHD7; TXN; HSPA5; ANK3; HSP90B1; JPH4; EPB41L3; CALR; KDELR1
GO:0072507	divalent inorganic cation homeostasis	2.43	2.14e-04	6.55e-03	19/103	SEPN1; SV2A; ATP1B1; AGT; RYR2; FKBP1B; SNCA; ANK2; CAMK2D; SRI; CHD7; ANK3; HSP90B1; TPT1; JPH4; NMB; CALR; CACNA1A; SMDT1
GO:0099177	regulation of trans-synaptic signaling	2.43	7.16e-06	7.06e-04	28/152	PRKCZ; CNTN2; AGT; GNAI2; CPLX1; NSG1; SNCA; CPLX2; GRM4; AKAP12; CAMK2B; AKAP9; DNM1; SYT7; ASIC1; PCDH17; JPH4; RAB26; CBLN1; EFNB3; VAMP2; MAPT; EIF4A3; BAIAP2; CELF4; SNAP25; CACNA1A; RAB3A
GO:0034764	positive regulation of transmembrane transport	2.40	3.51e-03	4.09e-02	12/66	ATP1B1; AGT; RYR2; CAPN10; SNCA; ANK2; GLRX; SRI; AKAP9; GAL; ANK3; KCNIP2
GO:0048568	embryonic organ development	2.39	2.78e-04	7.81e-03	19/105	MFAP2; NES; VASH2; RYR2; ID2; NCOA1; SIX3; NEUROD1; CTNNB1; IFT57; FAM65B; MDFI; SOBP; CHD7; CTHRC1; CDKN1C; SIX1; EIF4A3; TEAD2
GO:0050673	epithelial cell proliferation	2.38	5.82e-04	1.21e-02	17/94	JUN; VASH2; ID2; IGFBP5; SCG2; CTNNB1; GPX1; ROBO1; IFT57; SPARC; EGFL7; CDKN1C; SIX1; PGF; SERPINF1; NGFR; XBP1
GO:0097485	neuron projection guidance	2.38	5.82e-04	1.21e-02	17/94	SHC1; EFNA3; LHX9; CNTN2; ROBO1; ALCAM; GAP43; SPON2; EZR; ETV1; DPYSL2; SPTAN1; NCAM1; FEZ1; MYCBP2; EFNB3; BSG
GO:0042110	T cell activation	2.36	6.61e-04	1.28e-02	17/95	PRKCZ; FKBP1B; SATB1; CTNNB1; CD47; CASP3; SOX4; FAM65B; BTN2A2; CHD7; CD151; CADM1; B2M; EFNB3; PREX1; KDELR1; XBP1
GO:0042692	muscle cell differentiation	2.35	2.32e-04	6.81e-03	20/112	SEPN1; LMNA; RGS2; AGT; IGFBP5; DNER; CTNNB1; GPX1; WDR1; ANK2; CASP3; SORBS2; FAM65B; MTPN; NRG1; SIX1; ACTC1; WFIKKN1; CALR; XBP1
GO:0015849	organic acid transport	2.33	4.52e-03	4.88e-02	12/68	FABP3; SV2A; MPC2; RGS2; AGT; NCOA1; SNCA; SLC17A6; NMB; VAMP2; BSG; RAB3A
GO:0072511	divalent inorganic cation transport	2.31	2.97e-04	7.81e-03	20/114	SEPN1; ATP1B1; AGT; RYR2; FKBP1B; TMEM163; CTNNB1; GNAI2; SNCA; ANK2; CAMK2D; GPM6A; CAMK2B; SRI; CHD7; ASIC1; TPT1; JPH4; CACNA1A; SMDT1
GO:0019932	second-messenger-mediated signaling	2.29	1.30e-03	2.12e-02	16/92	SEPN1; ATP1B1; RGS2; AGT; RYR2; FKBP1B; NEUROD1; GNAI2; ANK2; CAMK2D; SRI; NRG1; GAL; JPH4; MAPT; PDE9A
GO:0001525	angiogenesis	2.28	5.14e-04	1.14e-02	19/110	JUN; SHC1; EFNA3; VASH2; AGT; SCG2; CTNNB1; GPX1; ROBO1; SPARC; VAV2; EGFL7; ATP5B; PGF; PKM; SERPINF1; NGFR; RNF213; XBP1
GO:0051047	positive regulation of secretion	2.26	7.87e-04	1.44e-02	18/105	PRKCZ; WLS; MPC2; AGT; CAPN10; GNAI2; SNCA; SOX4; EZR; SRI; SYT7; GAL; CADM1; DYNLL1; NMB; DOC2B; RAB3A; XBP1
GO:0023061	signal release	2.24	4.82e-05	2.36e-03	27/159	WLS; SV2A; MPC2; AGT; FKBP1B; NEUROD1; CAPN10; CPLX1; SNCA; CPLX2; SOX4; UQCC2; GRM4; SRI; CHD7; SYT7; GAL; ASIC1; DYNLL1; TRIM9; NMB; DOC2B; VAMP2; SNAP25; CACNA1A; RAB3A; SELM
GO:0042063	gliogenesis	2.22	2.52e-03	3.43e-02	15/89	MXRA8; POU3F1; PHGDH; CNTN2; ID2; DNER; CTNNB1; GAP43; WDR1; SOX4; HDAC2; NRG1; GSTP1; MAPT; LGI4
GO:0003013	circulatory system process	2.22	1.85e-03	2.73e-02	16/95	ATP1B1; RGS2; AGT; RYR2; ID2; FKBP1B; MYL1; GPX1; GNAI2; ANK2; CAMK2D; SRI; AKAP9; CHD7; KCNIP2; ACTC1
GO:0006898	receptor-mediated endocytosis	2.22	1.85e-03	2.73e-02	16/95	CNTN2; SNCA; SPARC; EZR; HIP1; DNM1; CALY; BICD1; CD63; HSP90B1; HSP90AA1; B2M; LGALS3BP; RAB31; SNAP25; CALR
GO:0002791	regulation of peptide secretion	2.22	7.26e-04	1.37e-02	19/113	PRKCZ; WLS; MPC2; FKBP1B; NEUROD1; CAPN10; SOX4; BTN2A2; UQCC2; EZR; SRI; CHD7; SYT7; CADM1; DYNLL1; DOC2B; SNAP25; CACNA1A; XBP1
GO:0010038	response to metal ion	2.20	8.12e-04	1.45e-02	19/114	JUN; S100A13; RYR2; ID2; SNCA; CAMK2D; CASP3; SPARC; HSPA5; SYT7; PPP1CA; ANK3; KCNIP2; B2M; SERPINF1; MAPT; BSG; CALR; MT-CO1
GO:0050808	synapse organization	2.17	2.14e-04	6.55e-03	24/146	PTPRF; CNTN2; CHRNA1; DNER; CTNNB1; GAP43; SNCA; GPM6A; SPARC; MDGA1; CAMK2B; FZD1; NEFL; NRG1; TNC; ANK3; PCDH17; POU4F1; SIX1; CBLN1; MAPT; BAIAP2; RAB3A; SEZ6L
GO:0010975	regulation of neuron projection development	2.16	1.43e-05	9.54e-04	33/201	PTPRF; CRABP2; RGS2; CNTN2; AGT; FKBP1B; ZEB2; MAP2; ITM2C; TWF2; PTPRG; ROBO1; TNIK; MAP1B; NR2F1; HDAC2; CAMK2B; FZD1; NEFL; DPYSL2; HSPA5; OLFM1; MYCBP2; B2M; LINGO1; SERPINF1; EFNB3; MAPT; NGFR; BAIAP2; SNAP25; PREX1; RTN4R
GO:0010721	negative regulation of cell development	2.16	1.01e-03	1.76e-02	19/116	RGS2; CNTN2; ID2; SIX3; MAP2; ITM2C; CTNNB1; PTPRG; NR2F1; HDAC2; NRG1; GAL; CORO1C; B2M; LINGO1; EFNB3; NGFR; CALR; RTN4R
GO:0048880	sensory system development	2.15	2.57e-03	3.43e-02	16/98	MFAP2; JUN; NES; SIX3; ZEB2; NEUROD1; CTNNB1; MAB21L2; GPM6A; HDAC2; DCX; CHD7; CDKN1C; POU4F1; SERPINF1; CELF4
GO:0022604	regulation of cell morphogenesis	2.15	4.08e-05	2.14e-03	30/184	EPB41; S100A13; CRABP2; CNTN2; ZEB2; MAP2; ARPC2; TWF2; ROBO1; TNIK; WDR1; MAP1B; SPARC; EZR; CAMK2B; NEFL; DPYSL2; OLFM1; CORO1C; MYCBP2; LINGO1; EFNB3; MAPT; NGFR; BAIAP2; MYL12B; EPB41L3; PREX1; CALR; RTN4R
GO:0021700	developmental maturation	2.15	3.51e-03	4.09e-02	15/92	RERE; CNTN2; ID2; SIX3; CTNNB1; CAMK2B; NEFL; CDKN1C; GAL; KCNIP2; CD63; RAB3A; LGI4; SEZ6L; XBP1
GO:0034330	cell junction organization	2.07	3.89e-03	4.46e-02	16/102	RAB13; AGT; PKP4; IQSEC1; CTNNB1; WDR1; ANK2; GPM6B; CD151; CADM1; VCL; SLK; CORO1C; EPB41L3; MAPRE2; PVRL2
GO:0002521	leukocyte differentiation	2.06	3.15e-03	3.90e-02	17/109	PRKCZ; JUN; ID2; SATB1; CMTM7; CTNNB1; SOX4; BTN2A2; CHD7; TPD52; FAM213A; POU4F1; B2M; PREX1; KDELR1; XBP1; MFNG
GO:0001505	regulation of neurotransmitter levels	2.01	3.09e-03	3.90e-02	18/118	PHGDH; SV2A; RGS2; AGT; CD47; CPLX1; SNCA; CPLX2; GRM4; GPM6B; SYT7; ASIC1; TRIM9; HSP90AA1; DOC2B; VAMP2; SNAP25; RAB3A

CHD2 : 32 significant GO terms

GeneSet	description	enrichRatio	pValue	FDR	GeneRatio	geneSymbols
GO:0070972	protein localization to endoplasmic reticulum	5.15	0.00e+00	0.00e+00	75/119	RPL22; RPL11; RPS8; RPL5; RPS27; RYR2; RPS27A; RPL31; RPL37A; RPL32; RPL15; RPSA; RPL14; RPL29; SPCS1; RPL24; RPL35A; RPL9; RPL34; RPS3A; RPL37; RPS23; RPS14; RPS18; RPL10A; RPS12; SEC61G; RPS4X; RPL36A; RPL39; RPL10; RPS20; RPL7; RPL30; RPL8; RPS6; SEC61B; HSPA5; RPL7A; RPLP2; RPL27A; RPS13; RPS3; RPS25; RPS24; RPL41; RPL6; RPLP0; RPL21; RPS29; SRP14; RPL4; RPLP1; RPS17; RPS2; RPS15A; RPL13; RPL26; RPL23A; RPL23; RPL19; RPL27; RPL38; RPL17; RPS15; RPL36; RPS28; RPL18A; RPS16; RPS19; RPL18; RPL13A; RPS9; RPS5; RPL3
GO:0014075	response to amine	4.90	4.46e-04	1.26e-02	6/10	RGS2; HDAC2; RGS10; CALM1; NME1; SOD1
GO:0010737	protein kinase A signaling	4.46	8.80e-04	2.15e-02	6/11	RAB13; AKAP12; EZR; GAL; AKAP6; MIF
GO:0051339	regulation of lyase activity	4.08	6.28e-04	1.65e-02	7/14	PARK7; HPCA; GNAI2; CAP2; AKAP9; GABBR2; PHPT1
GO:0006413	translational initiation	4.06	0.00e+00	0.00e+00	78/157	RPL22; RPL11; RPS8; RPL5; RPS27; DDX1; RPS27A; RPL31; RPL37A; RPL32; RPL15; RPSA; EIF1B; RPL14; RPL29; RPL24; EIF4A2; RPL35A; RPL9; RPL34; RPS3A; RPL37; RPS23; RPS14; RPS18; RPL10A; RPS12; RPS4X; RPL36A; RPL39; RPL10; EIF4EBP1; RPS20; RPL7; RPL30; EIF3E; EIF3H; RPL8; RPS6; RPL7A; RPLP2; EIF3F; RPL27A; RPS13; RPS3; RPS25; RPS24; RPL41; RPL6; RPLP0; RPL21; RPS29; EIF3J; RPL4; RPLP1; RPS17; RPS2; RPS15A; RPL13; RPL26; RPL23A; RPL23; RPL19; RPL27; RPL38; RPL17; RPS15; RPL36; RPS28; RPL18A; RPS16; RPS19; RPL18; RPL13A; RPS9; RPS5; EIF3L; RPL3
GO:0002181	cytoplasmic translation	3.92	4.22e-14	5.16e-12	35/73	RPL11; RPL31; RPL32; RPL15; RPL29; RPL24; RPL35A; RPL9; RPS23; RPL10A; RPL36A; RPL39; EIF4EBP1; RPL30; EIF3E; EIF3H; RPL8; EIF3F; RPL41; RPL6; RPLP0; RPS29; EIF3J; RPLP1; RPL26; RPL19; RPL38; RPL17; EEF2; RPL36; RPS28; RPL18A; RPL18; RPL13A; EIF3L
GO:0010644	cell communication by electrical coupling	3.77	2.63e-03	4.54e-02	6/13	ATP1B1; RYR2; FKBP1B; CAMK2D; SRI; CALM1
GO:0010257	NADH dehydrogenase complex assembly	3.68	2.31e-10	2.43e-08	27/60	NDUFS5; NDUFB3; NDUFAF3; NDUFB4; NDUFS6; NDUFA2; NDUFA5; NDUFB2; NDUFB11; NDUFA1; NDUFB9; TMEM261; NDUFB6; NDUFS8; NDUFC2; NDUFB8; NDUFB10; NDUFAB1; NDUFS7; NDUFA11; NDUFA7; NDUFB7; NDUFA13; NDUFA3; NDUFA6; MT-ND1; MT-ND3
GO:0090150	establishment of protein localization to membrane	3.52	0.00e+00	0.00e+00	88/204	RPL22; RPL11; HPCA; RPS8; RPL5; RPS27; ATP1B1; RPS27A; REEP1; RPL31; RPL37A; RPL32; RPL15; RPSA; RPL14; RPL29; RPL24; RPL35A; CPLX1; NSG1; RPL9; RPL34; RPS3A; RPL37; RPS23; RPS14; GNB2L1; RPS18; RPL10A; RPS12; FIS1; RPS4X; RPL36A; RPL39; RPL10; RPS20; RPL7; RPL30; YWHAZ; RPL8; RPS6; SEC61B; RPL7A; RPLP2; RPL27A; RPS13; TIMM10; RPS3; RPS25; RPS24; RPL41; RPL6; RPLP0; RPL21; RPS29; CALM1; SRP14; RPL4; RPLP1; RPS17; RPS2; RAB26; RPS15A; RPL13; VAMP2; RPL26; RPL23A; RPL23; RPL19; RPL27; RPL38; RAB31; RPL17; ROMO1; RPS15; TIMM13; RPL36; RPS28; RPL18A; NDUFA13; PDCD5; RPS16; RPS19; RPL18; RPL13A; RPS9; RPS5; RPL3
GO:0021675	nerve development	3.34	6.59e-04	1.67e-02	9/22	EPHB2; NRP2; CTNNB1; RPL24; CHD7; NTF3; POU4F1; SIX1; ADARB1
GO:0021953	central nervous system neuron differentiation	3.03	2.36e-06	1.24e-04	20/54	DRAXIN; EPHB2; LMO4; CNTN2; ZEB2; NRP2; MAP2; CTNNB1; ROBO1; UQCRQ; ID4; MDGA1; FZD1; MTPN; MYCBP2; POU4F1; CBLN1; MAPT; DCC; ADARB1
GO:0014074	response to purine-containing compound	2.93	1.17e-04	4.09e-03	14/39	SEPN1; JUN; RYR2; IGFBP5; SPARC; HDAC2; EZR; AKAP9; HSPA5; HSP90B1; AKAP6; NME1; BSG; SOD1
GO:0050954	sensory perception of mechanical stimulus	2.93	1.17e-04	4.09e-03	14/39	GPX1; WDR1; CASP3; FAM65B; SOBP; CHD7; NDUFB9; TIMM10; TIMM8B; SIX1; RPL38; TIMM13; RAB3A; SOD1
GO:0033108	mitochondrial respiratory chain complex assembly	2.91	1.13e-08	9.21e-07	31/87	NDUFS5; NDUFB3; NDUFAF3; COX17; NDUFB4; NDUFS6; NDUFA2; UQCC2; NDUFA5; NDUFB2; NDUFB11; NDUFA1; NDUFB9; TMEM261; NDUFB6; NDUFS8; NDUFC2; NDUFB8; NDUFB10; NDUFAB1; NDUFS7; NDUFA11; PET100; NDUFA7; NDUFB7; NDUFA13; NDUFA3; UQCR10; NDUFA6; MT-ND1; MT-ND3
GO:0006401	RNA catabolic process	2.84	0.00e+00	0.00e+00	82/236	RPL22; RPL11; YBX1; RPS8; RPL5; RPS27; RPS27A; RPL31; RPL37A; RPL32; LSM3; RPL15; RPSA; RPL14; PCBP4; RPL29; RPL24; RPL35A; RPL9; RPL34; RPS3A; RPL37; RPS23; RPS14; RPS18; RPL10A; RPS12; LSM5; LINC01420; RPS4X; RPL36A; RPL39; RPL10; RPS20; RPL7; RPL30; YWHAZ; EIF3E; RPL8; RPS6; RPL7A; RPLP2; RPL27A; RPS13; RNASEH2C; RPS3; RPS25; RPS24; RPL41; RPL6; RPLP0; RPL21; RPS29; SLIRP; RPL4; RPLP1; RPS17; RPS2; CARHSP1; RPS15A; RPL13; RPL26; RPL23A; RPL23; RPL19; RPL27; RPL38; EIF4A3; RPL17; CIRBP; RPS15; LSM7; RPL36; RPS28; RPL18A; RPS16; RPS19; RPL18; RPL13A; RPS9; RPS5; RPL3
GO:2001023	regulation of response to drug	2.82	1.59e-03	3.65e-02	10/29	PARK7; RGS2; AGT; NCOA1; SNCA; GNB2L1; TXN; SYT7; GAL; SNCG
GO:0006605	protein targeting	2.72	0.00e+00	0.00e+00	87/261	RPL22; RPL11; HPCA; RPS8; RPL5; RPS27; RPS27A; RPL31; RPL37A; RPL32; RPL15; RPSA; RPL14; RPL29; SPCS1; RPL24; RPL35A; RPL9; RPL34; RPS3A; RPL37; RPS23; RPS14; RPS18; RPL10A; RPS12; AKAP12; SEC61G; FIS1; SLC25A6; RPS4X; RPL36A; RPL39; RPL10; RPS20; RPL7; RPL30; YWHAZ; RPL8; RPS6; SEC61B; RPL7A; RPLP2; RPL27A; RPS13; TIMM10; RPS3; TIMM8B; RPS25; RPS24; RPL41; RPL6; RPLP0; RPL21; AKAP6; RPS29; SRP14; RPL4; RPLP1; RPS17; RPS2; RPS15A; RPL13; RPL26; RPL23A; RPL23; RPL19; RPL27; RPL38; RPL17; ROMO1; RPS15; TIMM13; RPL36; RPS28; UBL5; RPL18A; HOMER3; NDUFA13; PDCD5; RPS16; RPS19; RPL18; RPL13A; RPS9; RPS5; RPL3
GO:0046683	response to organophosphorus	2.64	1.70e-03	3.66e-02	11/34	JUN; IGFBP5; SPARC; EZR; AKAP9; HSPA5; HSP90B1; AKAP6; NME1; BSG; SOD1
GO:0003012	muscle system process	2.55	6.15e-08	4.52e-06	35/112	ENO1; TPM3; LMNA; NOS1AP; ATP1B1; RGS2; AGT; RYR2; FKBP1B; MYL1; IGFBP5; CAMK2D; SORBS2; NDUFS6; COL4A3BP; MEF2C; HDAC2; CAMK2B; SRI; CALD1; MTPN; VCL; KCNIP2; MYL6; AKAP6; CALM1; ALDOA; HSBP1; SSTR2; MYL12A; MYL12B; NEDD4L; EEF2; SOD1; PDE9A
GO:0032409	regulation of transporter activity	2.52	6.29e-06	2.57e-04	25/81	PARK7; EPHB2; SEPN1; HPCA; NOS1AP; ATP1B1; RYR2; FKBP1B; COX17; SNCA; CAMK2D; MEF2C; GLRX; SRI; AKAP9; TMSB4X; GAL; FXYD6; KCNIP2; JPH4; AKAP6; CALM1; VAMP2; NEDD4L; FXYD7
GO:0002576	platelet degranulation	2.50	2.83e-03	4.54e-02	11/36	TAGLN2; MANF; WDR1; SPARC; TMSB4X; VCL; CD63; CALM1; ALDOA; LGALS3BP; SOD1
GO:1902600	proton transmembrane transport	2.44	2.68e-05	1.03e-03	23/77	PARK7; COX5B; ATP5G3; COX17; ATP5I; COX7A2; NDUFA4; ATP5J2; ATP6V1F; ATP6V0E2; TMSB4X; COX7B; COX6C; COX8A; ATP5B; COX5A; ATP5G1; ATP5H; ATP5A1; ATP5E; NDUFS7; COX6B1; ATP5J
GO:0010959	regulation of metal ion transport	2.39	3.73e-06	1.82e-04	29/99	SEPN1; HPCA; NOS1AP; ATP1B1; AGT; RYR2; FKBP1B; CTNNB1; GNAI2; SNCA; CAMK2D; GLRX; CAMK2B; SRI; AKAP9; CHD7; GAL; FXYD6; KCNIP2; CD63; JPH4; AKAP6; CALM1; B2M; VAMP2; NEDD4L; NKAIN4; HOMER3; FXYD7
GO:0030534	adult behavior	2.36	2.13e-03	4.33e-02	13/45	PARK7; CNTN2; ID2; NRXN1; SNCA; HDAC2; CHD7; PBX3; SNCG; EFNB3; LGI4; SEZ6L; CSTB
GO:0034765	regulation of ion transmembrane transport	2.30	2.03e-06	1.15e-04	33/117	PARK7; EPHB2; SEPN1; HPCA; NOS1AP; ATP1B1; RGS2; AGT; RYR2; FKBP1B; SCN3A; SCN9A; COX17; WDR1; SNCA; CAMK2D; MEF2C; GLRX; SRI; AKAP9; TMSB4X; CHD7; GAL; FXYD6; KCNIP2; CD63; JPH4; AKAP6; CALM1; VAMP2; NEDD4L; CACNA1A; FXYD7
GO:0031099	regeneration	2.29	9.57e-04	2.27e-02	16/57	SEPN1; PTPRF; JUN; FKBP1B; GPX1; NREP; MTPN; NEFL; TNC; GSTP1; PGF; ENO3; RPL19; PHB; RPS16; RTN4R
GO:0009141	nucleoside triphosphate metabolic process	2.29	1.81e-09	1.66e-07	53/189	PARK7; ENO1; NDUFS5; UQCRH; ATP1B1; COX5B; ATP5G3; NDUFB3; NDUFB4; ATP5I; SNCA; NDUFS6; UQCRQ; NDUFA2; UQCC2; COX7A2; NDUFA4; CYCS; ATP5J2; NDUFA5; NDUFB2; TMSB4X; NDUFA1; NDUFB9; NDUFB6; AK1; NDUFS8; NDUFC2; NDUFB8; TPI1; ATP5B; RAN; COX5A; NME3; NDUFB10; NDUFAB1; ALDOA; DCTPP1; ENO3; ATP5G1; NME1; ATP5H; ATP5A1; ATP5E; NDUFS7; NDUFA7; NDUFB7; NDUFA3; UQCR10; NDUFA6; ATP5J; MT-ND1; MT-ND3
GO:0019932	second-messenger-mediated signaling	2.13	1.96e-04	6.25e-03	24/92	SEPN1; HPCA; NOS1AP; ATP1B1; RGS2; AGT; RYR2; FKBP1B; GNAI2; SELK; CAMK2D; HINT1; SRI; FIS1; NRG1; GAL; JPH4; AKAP6; CALM1; MAPT; GNAS; HOMER3; APLP1; PDE9A
GO:0034764	positive regulation of transmembrane transport	2.10	1.91e-03	4.00e-02	17/66	PARK7; EPHB2; NOS1AP; ATP1B1; AGT; RYR2; CAPN10; COX17; SNCA; GLRX; SRI; AKAP9; TMSB4X; GAL; KCNIP2; AKAP6; CALM1
GO:0009123	nucleoside monophosphate metabolic process	2.09	1.30e-07	8.69e-06	50/195	PARK7; ENO1; NDUFS5; UQCRH; ATP1B1; COX5B; ATP5G3; NDUFB3; NDUFB4; ATP5I; SNCA; NDUFS6; UQCRQ; NDUFA2; UQCC2; COX7A2; HDDC2; NDUFA4; CYCS; ATP5J2; NDUFA5; NDUFB2; TMSB4X; NDUFA1; NDUFB9; NDUFB6; AK1; NDUFS8; NDUFC2; NDUFB8; TPI1; ATP5B; COX5A; NDUFB10; NDUFAB1; ALDOA; ENO3; ATP5G1; ATP5H; ATP5A1; ATP5E; NDUFS7; NDUFA7; NDUFB7; NDUFA3; UQCR10; NDUFA6; ATP5J; MT-ND1; MT-ND3
GO:0097485	neuron projection guidance	2.09	2.79e-04	8.20e-03	24/94	DRAXIN; EPHB2; SHC1; EFNA3; LHX9; CNTN2; NRXN1; KIF5C; NRP2; ROBO1; RPL24; ALCAM; SPON2; PDLIM7; TUBB2B; EZR; ETV1; DPYSL2; SPTAN1; FEZ1; MYCBP2; EFNB3; DCC; BSG
GO:0043270	positive regulation of ion transport	2.04	2.70e-03	4.54e-02	17/68	PARK7; EPHB2; NOS1AP; ATP1B1; AGT; RYR2; COX17; SNCA; GLRX; SRI; AKAP9; TMSB4X; GAL; KCNIP2; AKAP6; CALM1; MIF

PTEN : 23 significant GO terms

GeneSet	description	enrichRatio	pValue	FDR	GeneRatio	geneSymbols
GO:0070972	protein localization to endoplasmic reticulum	4.79	0.00e+00	0.00e+00	85/119	RPL22; RPL11; RPS8; RPL5; RPS27; SRP9; RYR2; RPS7; RPS27A; RPL31; RPL37A; RPL32; RPL15; RPSA; RPL14; RPL29; SPCS1; RPL24; RPL35A; RPL9; RPL34; ANK2; RPS3A; RPL37; RPS23; RPS14; RPS18; RPS10; RPL10A; RPS12; SEC61G; RPS4X; RPL36A; RPL39; RPL10; RPS20; RPL7; RPL30; RPL8; RPS6; HSPA5; RPL12; RPL7A; RPLP2; RPL27A; RPS13; RPS3; RPS25; RPS24; RPS26; RPL41; RPL6; RPLP0; RPL21; RPS29; SRP14; RPL4; RPLP1; RPS17; RPS2; RPS15A; RPL13; RPL26; RPL23A; RPL23; RPL19; RPL27; RPL38; RPL17; RPS21; RPS15; RPL36; RPS28; RPL18A; UBA52; RPS16; RPS19; KDELR1; RPL18; RPL13A; RPS11; RPS9; RPL28; RPS5; RPL3
GO:0010644	cell communication by electrical coupling	4.12	1.52e-04	4.65e-03	8/13	ATP1B1; RYR2; FKBP1B; DBN1; SRI; ANK3; CALM1; HRC
GO:0007218	neuropeptide signaling pathway	4.02	1.33e-03	2.78e-02	6/10	PCSK1N; GAL; SCG5; NMB; SSTR2; PTH2
GO:0006413	translational initiation	3.88	0.00e+00	0.00e+00	91/157	RPL22; RPL11; RPS8; RPL5; RPS27; RPS7; RPS27A; RPL31; RPL37A; RPL32; RPL15; RPSA; RPL14; RPL29; RPL24; EIF4A2; RPL35A; RPL9; RPL34; RPS3A; RPL37; RPS23; RPS14; NPM1; RPS18; RPS10; RPL10A; RPS12; RPS4X; RPL36A; RPL39; MCTS1; RPL10; EIF4EBP1; RPS20; RPL7; RPL30; PABPC1; EIF3E; EIF3H; RPL8; RPS6; RPL12; RPL7A; RPLP2; EIF3F; RPL27A; RPS13; EIF3M; RPS3; RPS25; RPS24; RPS26; RPL41; RPL6; RPLP0; DENR; RPL21; RPS29; EIF3J; RPL4; RPLP1; RPS17; RPS2; RPS15A; RPL13; RPL26; RPL23A; RPL23; RPL19; RPL27; RPL38; RPL17; EIF2S2; RPS21; RPS15; RPL36; RPS28; RPL18A; UBA52; RPS16; RPS19; RPL18; RPL13A; RPS11; RPS9; RPL28; RPS5; EIF3D; EIF3L; RPL3
GO:0002181	cytoplasmic translation	3.85	0.00e+00	0.00e+00	42/73	RPL11; RPL31; RPL32; RPL15; TMA7; RPL29; RPL24; RPL35A; RPL9; RPS23; RPL10A; RPL36A; RPL39; MCTS1; EIF4EBP1; RPL30; EIF3E; EIF3H; RPL8; EIF3F; EIF3M; RPS26; RPL41; RPL6; RPLP0; DENR; RPS29; EIF3J; RPLP1; RPL26; RPL19; RPL38; RPL17; RPS21; EEF2; RPL36; RPS28; RPL18A; RPL18; RPL13A; EIF3D; EIF3L
GO:0051339	regulation of lyase activity	3.35	2.11e-03	4.07e-02	7/14	PARK7; HPCA; GNAI2; CAP2; AKAP9; GABBR2; PHPT1
GO:0010257	NADH dehydrogenase complex assembly	3.24	7.47e-10	7.84e-08	29/60	NDUFS5; NDUFB3; NDUFAF3; NDUFB4; NDUFC1; NDUFS6; NDUFA2; NDUFA5; NDUFB11; NDUFA1; NDUFB9; TMEM261; NDUFB6; NDUFA8; NDUFC2; NDUFB8; NDUFA12; NDUFB1; NDUFAB1; NDUFA11; NDUFA7; NDUFB7; NDUFA13; NDUFA3; NDUFA6; MT-ND1; MT-ND3; MT-ND4; MT-ND6
GO:0090150	establishment of protein localization to membrane	3.19	0.00e+00	0.00e+00	97/204	RPL22; RPL11; HPCA; RPS8; RPL5; RPS27; ATP1B1; SRP9; RPS7; RPS27A; REEP1; RPL31; RPL37A; RPL32; RPL15; RPSA; RPL14; RPL29; RPL24; RPL35A; CPLX1; NSG1; RPL9; RPL34; RPS3A; RPL37; RPS23; RPS14; GNB2L1; RPS18; RPS10; RPL10A; CD24; RPS12; FIS1; RPS4X; RPL36A; RPL39; RPL10; RPS20; RPL7; RPL30; YWHAZ; RPL8; RPS6; RPL12; RPL7A; RPLP2; RPL27A; RPS13; TIMM10; RPS3; RPS25; ANK3; RPS24; RPS26; RPL41; RPL6; RPLP0; RPL21; RPS29; CALM1; SRP14; RPL4; RPLP1; RPS17; RPS2; RPS15A; RPL13; YWHAE; VAMP2; RPL26; RPL23A; RPL23; RPL19; RPL27; RPL38; RAB31; RPL17; ROMO1; RPS21; RPS15; RPL36; RPS28; RPL18A; UBA52; NDUFA13; PDCD5; RPS16; RPS19; RPL18; RPL13A; RPS11; RPS9; RPL28; RPS5; RPL3
GO:0033108	mitochondrial respiratory chain complex assembly	2.77	1.50e-09	1.38e-07	36/87	NDUFS5; COX20; NDUFB3; NDUFAF3; COX17; NDUFB4; NDUFC1; NDUFS6; NDUFA2; UQCC2; NDUFA5; NDUFB11; NDUFA1; NDUFB9; TMEM261; NDUFB6; NDUFA8; NDUFC2; NDUFB8; COX14; NDUFA12; NDUFB1; NDUFAB1; COA3; NDUFA11; PET100; NDUFA7; NDUFB7; NDUFA13; NDUFA3; UQCR10; NDUFA6; MT-ND1; MT-ND3; MT-ND4; MT-ND6
GO:0099132	ATP hydrolysis coupled cation transmembrane transport	2.72	3.63e-04	9.54e-03	13/32	ATP6V0B; ATP2B4; ATP5G3; ATP6V1F; ATP6V0E2; ATP5L; ATP5G2; ATP5B; ATP2B1; ATP5G1; ATP5H; ATP5A1; ATP5E
GO:1902600	proton transmembrane transport	2.70	4.58e-08	3.16e-06	31/77	PARK7; ATP6V0B; COX5B; ATP5G3; COX17; ATP5I; COX7C; COX7A2; NDUFA4; ATP5J2; ATP6V1F; ATP6V0E2; TMSB4X; COX7B; COX6C; ATP6V1G1; COX8A; ATP5L; ATP5G2; ATP5B; COX6A1; COX5A; ATP5G1; ATP5H; ATP5A1; ATP5E; COX6B1; ATP5J; MT-CO2; MT-CO3; MT-ND4
GO:0035637	multicellular organismal signaling	2.65	6.94e-05	2.43e-03	17/43	ATP1B1; ATP2B4; AGT; RYR2; FKBP1B; SCN3A; SCN9A; CHRNA1; ANK2; SRI; AKAP9; SCN3B; ANK3; ATP2B1; CALM1; YWHAE; HRC
GO:0032409	regulation of transporter activity	2.65	4.74e-08	3.16e-06	32/81	PARK7; SEPN1; HPCA; NOS1AP; ATP1B1; RYR2; FKBP1B; COX17; SNCA; ANK2; MEF2C; GLRX; ACTB; SRI; AKAP9; TMSB4X; GAL; FXYD6; SCN3B; KIF5B; ANK3; KCNIP2; REM2; JPH4; AKAP6; CALM1; YWHAE; VAMP2; NEDD4L; FKBP1A; FXYD7; HRC
GO:0006401	RNA catabolic process	2.61	0.00e+00	0.00e+00	92/236	RPL22; RPL11; RPS8; RPL5; RPS27; RPS7; RPS27A; RPL31; RPL37A; RPL32; LSM3; RPL15; RPSA; RPL14; PCBP4; RPL29; RPL24; RPL35A; RPL9; RPL34; RPS3A; RPL37; RPS23; RPS14; NPM1; RPS18; RPS10; RPL10A; RPS12; LSM5; LINC01420; RPS4X; RPL36A; RPL39; RPL10; RPS20; RPL7; RPL30; PABPC1; YWHAZ; EIF3E; RPL8; RPS6; RPL12; RPL7A; RPLP2; RPL27A; RPS13; RPS3; RPS25; RPS24; MAGOHB; RPS26; RPL41; CNOT2; RPL6; RPLP0; RPL21; RPS29; SLIRP; RPL4; RPLP1; RPS17; RPS2; RPS15A; RPL13; RPL26; RPL23A; RPL23; RPL19; NT5C3B; RPL27; RPL38; EIF4A3; RPL17; RPS21; RPS15; LSM7; RPL36; RPS28; RPL18A; LSM4; UBA52; RPS16; RPS19; RPL18; RPL13A; RPS11; RPS9; RPL28; RPS5; RPL3
GO:0006605	protein targeting	2.54	0.00e+00	0.00e+00	99/261	RPL22; RPL11; ATPIF1; HPCA; RPS8; RPL5; RPS27; SRP9; TOMM20; RPS7; RPS27A; RPL31; RPL37A; RPL32; RPL15; RPSA; RPL14; RPL29; SPCS1; RPL24; RPL35A; RPL9; RPL34; RPS3A; RPL37; RPS23; RPS14; RPS18; RPS10; RPL10A; RPS12; AKAP12; SEC61G; FIS1; SLC25A6; TIMM17B; RPS4X; RPL36A; RPL39; RPL10; RPS20; RPL7; RPL30; YWHAZ; RPL8; RPS6; RPL12; RPL7A; RPLP2; RPL27A; RPS13; IMMP1L; TIMM10; RPS3; TIMM8B; RPS25; ANK3; RPS24; RPS26; RPL41; RPL6; RPLP0; RPL21; AKAP6; RPS29; SRP14; RPL4; RPLP1; RPS17; RPS2; RPS15A; RPL13; RPL26; RPL23A; RPL23; RPL19; RPL27; RPL38; RPL17; ROMO1; RPS21; RPS15; RPL36; RPS28; UBL5; RPL18A; UBA52; HOMER3; NDUFA13; PDCD5; RPS16; RPS19; RPL18; RPL13A; RPS11; RPS9; RPL28; RPS5; RPL3
GO:0021953	central nervous system neuron differentiation	2.48	4.91e-05	1.90e-03	20/54	DRAXIN; LMO4; CNTN2; NRP2; MAP2; ROBO1; UQCRQ; ID4; MDGA1; HSP90AB1; FZD1; MTPN; NFIB; C12orf57; MYCBP2; POU4F1; CBLN1; MAPT; DCC; ADARB1
GO:0010959	regulation of metal ion transport	2.37	2.90e-07	1.77e-05	35/99	SEPN1; NKAIN1; HPCA; NOS1AP; ATP1B1; ATP2B4; AGT; RYR2; FKBP1B; GNAI2; SNCA; ANK2; GLRX; SRI; AKAP9; CHD7; GAL; FXYD6; SCN3B; KIF5B; ANK3; KCNIP2; CD63; REM2; JPH4; AKAP6; CALM1; YWHAE; VAMP2; NEDD4L; FKBP1A; NKAIN4; HOMER3; FXYD7; HRC
GO:0034765	regulation of ion transmembrane transport	2.23	3.60e-07	1.89e-05	39/117	PARK7; SEPN1; HPCA; NOS1AP; ATP1B1; RGS2; ATP2B4; AGT; RYR2; FKBP1B; SCN3A; SCN9A; COX17; SNCA; ANK2; MEF2C; GLRX; SRI; AKAP9; TMSB4X; CHD7; GAL; FXYD6; SCN3B; KIF5B; ANK3; KCNIP2; CD63; REM2; JPH4; AKAP6; CALM1; YWHAE; VAMP2; NEDD4L; FKBP1A; CACNA1A; FXYD7; HRC
GO:0072507	divalent inorganic cation homeostasis	2.21	2.63e-06	1.21e-04	34/103	SEPN1; SV2A; ATP1B1; ATP2B4; AGT; RYR2; FKBP1B; SELK; SNCA; ANK2; CD24; SRI; FIS1; CHD7; GNG3; ANK3; ATP2B1; HSP90B1; HMGB1; TPT1; JPH4; AKAP6; CALM1; NMB; MT1F; MT1X; YWHAE; EIF5A; FKBP1A; CALR; CACNA1A; HRC; KCTD17; SMDT1
GO:0019932	second-messenger-mediated signaling	2.11	3.84e-05	1.56e-03	29/92	SEPN1; HPCA; NOS1AP; ATP1B1; RGS2; ATP2B4; AGT; RYR2; FKBP1B; NEUROD1; GNAI2; SELK; ANK2; HINT1; DDAH2; SRI; FIS1; NRG1; NCALD; GAL; PEBP1; JPH4; AKAP6; CALM1; MAPT; FKBP1A; HOMER3; APLP1; HRC
GO:0009914	hormone transport	2.06	1.19e-04	3.79e-03	27/88	PARK7; SLC16A1; MPC2; AGT; FKBP1B; NEUROD1; CAPN10; CPLX1; UQCC2; HMGN3; SRI; SLC25A6; SLC25A5; CHD7; ENY2; PHPT1; SYT7; GAL; KIF5B; DYNLL1; SCG5; NMB; DOC2B; VAMP2; MIDN; CACNA1A; SELM
GO:0034764	positive regulation of transmembrane transport	2.03	1.06e-03	2.50e-02	20/66	PARK7; NOS1AP; ATP1B1; AGT; RYR2; CAPN10; COX17; SNCA; ANK2; GLRX; SRI; AKAP9; TMSB4X; GAL; KIF5B; ANK3; KCNIP2; OSBPL8; AKAP6; CALM1
GO:0009141	nucleoside triphosphate metabolic process	2.02	4.11e-08	3.16e-06	57/189	PARK7; ATPIF1; NDUFS5; ATP1B1; COX5B; ATP5G3; NDUFB3; IMPDH2; NDUFB4; ATP5I; SNCA; NDUFC1; NDUFS6; COX7C; UQCRQ; NDUFA2; UQCC2; COX7A2; NDUFA4; CYCS; ATP5J2; NDUFA5; TMSB4X; NDUFA1; NDUFB9; NDUFB6; NDUFA8; NDUFC2; ATP5L; PGAM1; NDUFB8; ENO2; ATP5G2; ATP5B; NDUFA12; COX6A1; NDUFB1; COX5A; NME3; NDUFAB1; DCTPP1; ENO3; ATP5G1; ATP5H; ATP5A1; ATP5E; NDUFA7; NDUFB7; NDUFA3; UQCR10; NDUFA6; ATP5J; MT-ND1; MT-CO2; MT-CO3; MT-ND3; MT-ND4

SETD5 : 25 significant GO terms

GeneSet	description	enrichRatio	pValue	FDR	GeneRatio	geneSymbols
GO:0070972	protein localization to endoplasmic reticulum	6.62	0.00e+00	0.00e+00	83/119	RPL22; RPL11; RPS8; RPL5; RPS27; RPS7; RTN4; RPS27A; RPL31; RPL37A; RPL32; RPL15; RPSA; RPL14; RPL29; SPCS1; RPL24; RPL35A; RPL9; RPL34; RPS3A; RPL37; RPS23; RPS14; RPS18; RPS10; RPL10A; RPS12; RPS4X; RPL36A; RPL39; RPL10; RPS20; RPL7; RPL30; RPL8; RPS6; SEC61B; RPL35; HSPA5; RPL12; RPL7A; RPLP2; RPL27A; RPS13; RPS3; RPS25; RPS24; RPL41; RPL6; RPLP0; RPL21; RPS29; SRP14; RPL4; RPLP1; RPS17; RPS2; RPS15A; RPL13; RPL26; RPL23A; RPL23; RPL19; RPL27; RPL38; RPL17; RPS21; RPS15; RPL36; RPS28; RPL18A; UBA52; RPS16; RPS19; KDELR1; RPL18; RPL13A; RPS11; RPS9; RPL28; RPS5; RPL3
GO:0006413	translational initiation	5.56	0.00e+00	0.00e+00	92/157	RPL22; RPL11; RPS8; RPL5; RPS27; RPS7; DDX1; RPS27A; EIF5B; RPL31; RPL37A; RPL32; RPL15; RPSA; RPL14; RPL29; RPL24; EIF4A2; RPL35A; RPL9; RPL34; RPS3A; RPL37; RPS23; RPS14; NPM1; RPS18; RPS10; RPL10A; RPS12; RPS4X; RPL36A; RPL39; RPL10; EIF4EBP1; RPS20; RPL7; RPL30; PABPC1; EIF3E; EIF3H; RPL8; RPS6; RPL35; RPL12; RPL7A; RPLP2; RPL27A; RPS13; EIF3M; RPS3; RPS25; RPS24; EIF3A; RPL41; RPL6; RPLP0; RPL21; RPS29; EIF3J; RPL4; RPLP1; RPS17; RPS2; RPS15A; RPL13; RPL26; RPL23A; RPL23; RPL19; RPL27; RPL38; RPL17; EIF2S2; RPS21; RPS15; RPL36; RPS28; RPL18A; UBA52; RPS16; RPS19; RPL18; RPL13A; RPS11; RPS9; RPL28; RPS5; EIF3D; EIF3L; RPL3; ATF4
GO:0002181	cytoplasmic translation	4.94	0.00e+00	0.00e+00	38/73	RPL11; RPL31; RPL32; RPL15; RPL29; RPL24; RPL35A; RPL9; RPS23; RPL10A; RPL36A; RPL39; EIF4EBP1; RPL30; EIF3E; EIF3H; RPL8; EIF3M; EIF3A; RPL41; RPL6; RPLP0; RPS29; EIF3J; RPLP1; RPL26; RPL19; RPL38; RPL17; RPS21; EEF2; RPL36; RPS28; RPL18A; RPL18; RPL13A; EIF3D; EIF3L
GO:0090150	establishment of protein localization to membrane	4.14	0.00e+00	0.00e+00	89/204	RPL22; RPL11; RPS8; RPL5; RPS27; ATP1B1; CNST; RPS7; RPS27A; RPL31; RPL37A; RPL32; RPL15; RPSA; RPL14; RPL29; RPL24; RPL35A; RPL9; RPL34; RPS3A; RPL37; RPS23; RPS14; GNB2L1; RPS18; RPS10; RPL10A; RPS12; FIS1; RPS4X; RPL36A; RPL39; RPL10; RPS20; RPL7; RPL30; RPL8; RPS6; SEC61B; RPL35; RPL12; RPL7A; RPLP2; RPL27A; RPS13; TIMM10; BAD; RPS3; RPS25; RPS24; RPL41; RPL6; RPLP0; RPL21; RPS29; SRP14; RPL4; RPLP1; RPS17; RPS2; RPS15A; RPL13; RPL26; RPL23A; RPL23; RPL19; RPL27; RPL38; RPL17; ROMO1; RPS21; RPS15; TIMM13; RPL36; RPS28; RPL18A; UBA52; NDUFA13; PDCD5; RPS16; RPS19; RPL18; RPL13A; RPS11; RPS9; RPL28; RPS5; RPL3
GO:0010257	NADH dehydrogenase complex assembly	4.11	4.75e-11	3.44e-09	26/60	NDUFS5; NDUFB3; NDUFAF3; NDUFB4; NDUFA2; NDUFB2; NDUFB11; NDUFA1; NDUFB9; TMEM261; NDUFB6; NDUFA8; NDUFS8; NDUFC2; NDUFB1; NDUFB10; NDUFAB1; NDUFS7; NDUFA11; NDUFA7; NDUFB7; NDUFA13; NDUFA3; NDUFA6; MT-ND2; MT-ND3
GO:0006401	RNA catabolic process	3.90	0.00e+00	0.00e+00	97/236	RPL22; RPL11; YBX1; RPS8; SERBP1; RPL5; RPS27; RPS7; RPS27A; RPL31; SSB; RPL37A; RPL32; LSM3; RPL15; RPSA; RPL14; RPL29; RPL24; RPL35A; RPL9; HNRNPD; RPL34; RPS3A; RPL37; RPS23; RPS14; NPM1; RPS18; RPS10; RPL10A; RPS12; LSM5; RPS4X; RPL36A; RPL39; RPL10; DKC1; RPS20; RPL7; RPL30; PABPC1; EIF3E; RPL8; RPS6; RPL35; RPL12; RPL7A; RPLP2; RPL27A; RPS13; RNASEH2C; RPS3; RPS25; HSPA8; RPS24; RPL41; RPL6; RPLP0; UBC; RPL21; HNRNPC; RPS29; RPL4; RPLP1; RPS17; RPS2; RPS15A; RPL13; RPL26; RPL23A; RPL23; RPL19; RPL27; DDX5; RPL38; RPL17; RPS21; CIRBP; RPS15; LSM7; RPL36; RPS28; HNRNPM; C19orf43; RPL18A; LSM4; UBA52; RPS16; RPS19; RPL18; RPL13A; RPS11; RPS9; RPL28; RPS5; RPL3
GO:0006959	humoral immune response	3.56	4.55e-04	1.45e-02	9/24	HMGN2; SPON2; RPL39; RPL30; SERPING1; C1QBP; PHB; ROMO1; RPS19
GO:0006605	protein targeting	3.53	0.00e+00	0.00e+00	97/261	RPL22; RPL11; ATPIF1; RPS8; RPL5; RPS27; TOMM20; RPS7; RPS27A; RPL31; HSPD1; RPL37A; RPL32; RPL15; RPSA; RPL14; RPL29; SPCS1; RPL24; RPL35A; RPL9; RPL34; RPS3A; RPL37; RPS23; LARS; RPS14; RPS18; RPS10; RPL10A; RPS12; FIS1; SLC25A6; RPS4X; RPL36A; RPL39; RPL10; RPS20; RPL7; RPL30; RPL8; RPS6; SEC61B; RPL35; RPL12; RPL7A; RPLP2; RPL27A; RPS13; IMMP1L; TIMM10; RPS3; TIMM8B; RPS25; HSPA8; RPS24; RPL41; RPL6; RPLP0; UBC; RPL21; AKAP6; RPS29; SRP14; RPL4; RPLP1; RPS17; RPS2; RPS15A; RPL13; RPL26; RPL23A; RPL23; RPL19; RPL27; RPL38; RPL17; ROMO1; RPS21; RPS15; TIMM13; RPL36; RPS28; UBL5; RPL18A; UBA52; NDUFA13; PDCD5; RPS16; RPS19; RPL18; RPL13A; RPS11; RPS9; RPL28; RPS5; RPL3
GO:0033108	mitochondrial respiratory chain complex assembly	3.49	5.15e-11	3.44e-09	32/87	NDUFS5; COX20; NDUFB3; NDUFAF3; COX17; NDUFB4; NDUFA2; UQCC2; NDUFB2; NDUFB11; NDUFA1; UQCRB; NDUFB9; TMEM261; NDUFB6; NDUFA8; NDUFS8; NDUFC2; NDUFB1; NDUFB10; NDUFAB1; COA3; NDUFS7; NDUFA11; PET100; NDUFA7; NDUFB7; NDUFA13; NDUFA3; NDUFA6; MT-ND2; MT-ND3
GO:0046683	response to organophosphorus	3.35	1.02e-04	4.00e-03	12/34	JUN; HSPD1; EZR; HSPA5; RAPGEF1; LDHA; HSP90B1; AKAP6; NME1; BSG; JUND; SOD1
GO:0014074	response to purine-containing compound	3.16	1.04e-04	4.00e-03	13/39	SEPN1; JUN; HSPD1; EZR; HSPA5; RAPGEF1; LDHA; HSP90B1; AKAP6; NME1; BSG; JUND; SOD1
GO:1902600	proton transmembrane transport	3.08	1.25e-07	5.74e-06	25/77	PARK7; COX7A2L; COX5B; ATP5G3; COX17; COX7C; COX7A2; NDUFA4; ATP5J2; ATP6V1F; COX7B; COX6C; COX8A; ATP5L; COX5A; COX4I1; ATP5G1; ATP5H; CYB5A; ATP5E; ATP5D; NDUFS7; COX6B1; ATP5J; MT-CYB
GO:0001906	cell killing	3.05	1.64e-03	4.29e-02	9/28	HMGN2; PRDX1; HSP90AB1; RPL30; BAD; CADM1; EMP2; ROMO1; RPS19
GO:0009141	nucleoside triphosphate metabolic process	2.81	1.04e-13	1.09e-11	56/189	PARK7; ENO1; ATPIF1; NDUFS5; UQCRH; ATP1B1; COX7A2L; COX5B; ATP5G3; NDUFB3; IMPDH2; NDUFB4; COX7C; UQCRQ; NDUFA2; UQCC2; COX7A2; NDUFA4; CYCS; ATP5J2; NDUFB2; NDUFA1; UQCRB; NDUFB9; NDUFB6; NDUFA8; LDHA; BAD; NDUFS8; NDUFC2; ATP5L; HSPA8; DDIT4; RAN; NDUFB1; COX5A; NME4; NDUFB10; NDUFAB1; DCTPP1; COX4I1; ENO3; ATP5G1; NME1; ATP5H; ATP5E; ATP5D; NDUFS7; NDUFA7; NDUFB7; NDUFA3; NDUFA6; ATP5J; MT-ND2; MT-ND3; MT-CYB
GO:0009123	nucleoside monophosphate metabolic process	2.63	6.01e-12	5.52e-10	54/195	PARK7; ENO1; ATPIF1; NDUFS5; UQCRH; ATP1B1; COX7A2L; COX5B; ATP5G3; NDUFB3; IMPDH2; NDUFB4; PAICS; COX7C; UQCRQ; NDUFA2; UQCC2; COX7A2; HDDC2; NDUFA4; CYCS; ATP5J2; NDUFB2; NDUFA1; UQCRB; NDUFB9; NDUFB6; NDUFA8; LDHA; BAD; NDUFS8; NDUFC2; ATP5L; HSPA8; DDIT4; NDUFB1; COX5A; NDUFB10; NDUFAB1; COX4I1; ENO3; ATP5G1; ATP5H; ATP5E; ATP5D; NDUFS7; NDUFA7; NDUFB7; NDUFA3; NDUFA6; ATP5J; MT-ND2; MT-ND3; MT-CYB
GO:0032103	positive regulation of response to external stimulus	2.47	1.52e-03	4.14e-02	13/50	PARK7; AGT; FKBP1B; HSPD1; TUBB2B; FAM65B; NTF3; HMGB1; C1QBP; CALR; RPS19; MIF; DDT
GO:0016072	rRNA metabolic process	2.33	7.38e-08	3.61e-06	42/171	RPL11; RPS8; RPL5; RPS27; RPS7; WDR43; NOP58; NCL; RPSA; RPL14; RPL35A; LYAR; RPS14; NHP2; RPL10A; GTF2H5; DKC1; RPL7; RPS6; RPL35; RPL7A; TRMT112; DDX21; RPS24; NPM3; PA2G4; RPS17; RPS2; RPL26; RPL27; MAPT; RPS21; RPS15; RPS28; C19orf43; RPS16; FBL; RPS19; CD3EAP; GLTSCR2; RPS9; SNU13
GO:0031099	regeneration	2.33	1.84e-03	4.51e-02	14/57	SEPN1; PTPRF; JUN; FKBP1B; GPX1; GAP43; NEFL; TNC; GSTP1; ENO3; RPL19; PHB; RPS16; MT-CYB
GO:0072593	reactive oxygen species metabolic process	2.32	1.60e-04	5.60e-03	21/86	PARK7; ATPIF1; PRDX1; PRDX6; AGT; HSPD1; GPX1; DDAH2; HSP90AB1; PRDX4; PRDX5; GSTP1; DDIT4; SH3PXD2A; EIF5A; MAPT; ROMO1; PRDX2; NDUFA13; SOD1; MT-ND2
GO:0071826	ribonucleoprotein complex subunit organization	2.31	3.37e-08	1.77e-06	45/185	MRPL20; RPL11; RPL5; RPS27; SNRPE; DDX1; SNRPG; LSM3; RPSA; RPL24; RPS23; RPS14; NPM1; RPS10; HSP90AB1; RBMX; RPL10; EIF3E; EIF3H; RPL12; EIF3M; EIF3A; SNRPF; RPL6; RPLP0; EIF3J; C1QBP; RPL23A; MAPT; RPL38; SNRPD1; SNRPB; CIRBP; RPS15; RPS28; LSM4; RPS19; SNRPD2; GLTSCR2; RPL13A; RPS5; EIF3D; EIF3L; RPL3; SNU13
GO:0009259	ribonucleotide metabolic process	2.22	8.25e-10	5.05e-08	60/257	PARK7; ENO1; ATPIF1; NDUFS5; UQCRH; ATP1B1; COX7A2L; COX5B; DBI; ATP5G3; NDUFB3; IMPDH2; NDUFB4; PAICS; COX7C; HINT1; UQCRQ; NDUFA2; UQCC2; COX7A2; ELOVL4; NDUFA4; CYCS; ATP5J2; NDUFB2; NDUFA1; UQCRB; NDUFB9; NDUFB6; NDUFA8; LDHA; BAD; NDUFS8; NDUFC2; ATP5L; HSPA8; DDIT4; SCD; RAN; NDUFB1; COX5A; NME4; NDUFB10; NDUFAB1; COX4I1; ENO3; ATP5G1; NME1; ATP5H; ATP5E; ATP5D; NDUFS7; NDUFA7; NDUFB7; NDUFA3; NDUFA6; ATP5J; MT-ND2; MT-ND3; MT-CYB
GO:0022613	ribonucleoprotein complex biogenesis	2.19	6.82e-12	5.57e-10	76/330	MRPL20; RPL11; RPS8; RPL5; RPS27; SNRPE; RPS7; DDX1; WDR43; SNRPG; NOP58; LSM3; RPSA; RPL14; RPL24; RPL35A; LYAR; RPS23; RPS14; NPM1; NOP16; NHP2; PAK1IP1; RPS10; RPL10A; HSP90AB1; GTF2H5; RBMX; RPL10; DKC1; RPL7; EIF3E; EIF3H; RPS6; RPL35; RPL12; RPL7A; EIF3M; TRMT112; DDX21; RPS24; NPM3; EIF3A; PA2G4; SNRPF; RPL6; RPLP0; RAN; EIF3J; RPS17; RPS2; C1QBP; RPL26; RPL23A; RPL27; MAPT; RPL38; SNRPD1; SNRPB; RPS21; CIRBP; RPS15; RPS28; LSM4; RPS16; FBL; RPS19; SNRPD2; GLTSCR2; RPL13A; RPS9; RPS5; EIF3D; EIF3L; RPL3; SNU13
GO:0001101	response to acid chemical	2.18	2.08e-04	6.94e-03	23/100	FABP3; LAMTOR5; LAMTOR2; TOMM20; SST; HNRNPD; CASP3; LARS; ASNS; LAMTOR4; FIS1; TNC; BAD; CFL1; GSTP1; SCD; SERPINF1; NME1; BAIAP2; EEF2; NDUFA13; TEAD2; XBP1
GO:0006091	generation of precursor metabolites and energy	2.18	4.25e-09	2.40e-07	57/248	PARK7; ENO1; ATPIF1; NDUFS5; UQCRH; COX20; COX7A2L; COX5B; NDUFB3; COX17; NDUFB4; COX7C; UQCRQ; NDUFA2; UQCC2; COX7A2; NDUFA4; CYCS; ATP5J2; NDUFB2; COX7B; NDUFA1; UQCRB; COX6C; NDUFB9; NDUFB6; NDUFA8; LDHA; COX8A; NDUFS8; NDUFC2; ATP5L; CISD1; DDIT4; HMGB1; NDUFB1; COX5A; NDUFB10; NDUFAB1; COX4I1; ENO3; ATP5H; CYB5A; ATP5E; ATP5D; NDUFS7; UQCR11; NDUFA7; NDUFB7; COX6B1; GLTSCR2; NDUFA3; NDUFA6; ATP5J; MT-ND2; MT-ND3; MT-CYB
GO:0001819	positive regulation of cytokine production	2.09	9.88e-04	2.90e-02	20/91	PARK7; AGT; DDX1; HSPD1; SELK; SPON2; HMGB2; AGPAT2; RPS3; CADM1; DDX21; DDIT3; HMGB1; C1QBP; GLTSCR2; MIF; DDT; XBP1; ATF4; SOD1

Summary:
Marker	ADNP	CHD2	PTEN	SETD5
Signif_GO_terms	69	32	23	25

Guided Factor Analysis on LUHMES CROP-seq Data

-- Deviance residual transformed + normal-mixture prior + by-stage estimation

Yifan Zhou (zhouyf@uchicago.edu)

2021-11-15