Guided Factor Analysis on LUHMES CROP-seq Data

-- Deviance residual transformed + 4 covariates corrected

1 Single cell expression data

Source:
High-throughput single-cell functional elucidation of neurodevelopmental disease-associated genes reveals convergent mechanisms altering neuronal differentiation, GEO accession: GSE142078.

Perturbations:
CRISPR knock-down of 14 autism spectrum disorder (ASD)–associated genes (3 gRNAs per gene) + 5 non-targeting gRNAs.

Cells:
Lund human mesencephalic (LUHMES) neural progenitor cell line.
Cells from 3 batches were merged together into 1 analysis. All cells have only a single type of gRNA readout. Quality control resulted in 8708 cells.

Genes:
Top 6000 genes ranked by the multinomial deviance statistics were kept.

Normalization:
Deviance residual transformation.
Batch effect, unique UMI count, library size, and mitochondria percentage were all corrected for. The corrected and scaled expression data were used as input for subsequent factor analysis.

Here, our "guide", \(G\) matrix, consists of 15 types (14 genes + NTC) of gene-level knock-down conditions across cells.

In each case, Gibbs sampling was conducted for 3000 iterations, and the posterior mean estimates were averaged over the last 1000 iterations. SVD Initialization.

1.1 Monocle Pseudotime Trajectory

We attempted to reproduce the pseudotime trajectory of cells as reported in the original paper.

1.2 Marker Gene Expression in Pseudotime

Neuronal markers (MAP2 and DCX) increase along the pseudotime trajectory, whereas progenitor markers (TP53 and CDK4) decrease, consistent with Fig 3B of original paper.

Neuron progenitor (NPC): TP53, CDK4, NEUROD1, NES?
Post-mitotic neuron: MAP2, DCX, STMN2

2 Factor ~ Perturbation Association

2.1 Estimate of Factor ~ Perturbation Associations (\(\beta\))

2.2 Factor ~ Perturbation Association P Values

2.2.1 Beta PIP vs P-Value

2.2.2 Correlation btw Factors

3 Factor Interpretation

3.1 Factor by gene loading

Neuronal cell markers obtained from papers and Neuronal and Glial Cell Marker Atlas:

protein_name	gene_name	type
Nestin	NES	Radial Glia
Tenascin C	TNC	Radial Glia
TP53	TP53	NPC
CDK4	CDK4	NPC
NeuroD1	NEUROD1	Immature Neurons
Doublecortin	DCX	Immature, Post-mitotic
STMN2	STMN2	Post-mitotic
MAP2	MAP2	Mature, Post-mitotic
NeuN	RBFOX3	Mature Neurons
Neurofilament-L	NEFL	Mature Neurons
Neurofilament-M	NEFM	Mature Neurons
UCHL1	UCHL1	Mature Neurons
VGLUT2	SLC17A6	Glutamate, Excitatory
GIRK2	KCNJ6	Dopamine, Inhibitory
Somatostatin	SST	GABA, Inhibitory
EBF1	EBF1	Cortical

Markers in Fig 4E of original paper (Lalli et al):
SERPINF1 to ITM2C: negative regulators of neuron projection and differentiation
ZEB2 to DPYSL3: neuron maturation markers

3.2 Selected factor GO enrichment

4 DEG Interpretation

4.1 Number of DEGs detected under different methods

4.2 Perturbation effect on gene markers

Neuronal cell markers obtained from papers and Neuronal and Glial Cell Marker Atlas:

protein_name	gene_name	type
Nestin	NES	Radial Glia
Tenascin C	TNC	Radial Glia
TP53	TP53	NPC
CDK4	CDK4	NPC
NeuroD1	NEUROD1	Immature Neurons
Doublecortin	DCX	Immature, Post-mitotic
STMN2	STMN2	Post-mitotic
MAP2	MAP2	Mature, Post-mitotic
NeuN	RBFOX3	Mature Neurons
Neurofilament-L	NEFL	Mature Neurons
Neurofilament-M	NEFM	Mature Neurons
UCHL1	UCHL1	Mature Neurons
VGLUT2	SLC17A6	Glutamate, Excitatory
GIRK2	KCNJ6	Dopamine, Inhibitory
Somatostatin	SST	GABA, Inhibitory
EBF1	EBF1	Cortical

Markers in Fig 4E of original paper (Lalli et al):
SERPINF1 to ITM2C: negative regulators of neuron projection and differentiation
ZEB2 to DPYSL3: neuron maturation markers

4.3 DEG GO enrichment

5 Gene Set Enrichment Analysis by Factor

Target genes: Genes w/ non-zero loadings in each factor (PIP cutoff at 0.95);
Backgroud genes: all 6000 genes used in factor analysis;
Statistical test: hypergeometric test (over-representation test);
Only GO terms/pathways that satisfy fold change \(\geq\) 2 and test FDR \(<\) 0.05 are shown below.

5.1 GO Slim Over-Representation Analysis

Gene sets: Gene ontology "Biological Process" (non-redundant).

Factor 1 : 12 significant GO terms

GeneSet	description	enrichRatio	pValue	FDR	GeneRatio	geneSymbols
GO:0006414	translational elongation	4.14	1.08e-12	7.93e-10	32/109	MRPL37; MRPL9; MRPS9; MRPS22; MRPL47; MRPS18C; MRPS30; MRPL22; MRPS18B; MRPS10; MRPL2; MRPS18A; EEF1A1; MRPL32; MRPL15; MRPL50; MRPS2; MRPL21; MRPL51; MRPL42; MRPL46; MRPS11; MRPS34; MRPL27; ICT1; MRPS7; EIF4A3; MRPL12; MRPS26; EEF2; GADD45GIP1; MRPL39
GO:0140053	mitochondrial gene expression	3.52	9.44e-10	3.46e-07	29/116	MRPL37; MRPL9; MRPS9; MRPS22; MRPL47; MRPS18C; MRPS30; MRPL22; MRPS18B; MRPS10; MRPL2; MRPS18A; MRPL32; MRPL15; MRPL50; MRPS2; MRPL21; MRPL51; MRPL42; MRPL46; MRPS11; MRPS34; MRPL27; ICT1; MRPS7; MRPL12; MRPS26; GADD45GIP1; MRPL39
GO:0070972	protein localization to endoplasmic reticulum	3.08	1.43e-07	2.09e-05	26/119	RPS7; RPS27A; RPSA; SEC62; RPL9; ANK2; RPL37; RPS10; RPS12; RPL10; RPS6; SPCS2; RPL41; RPS29; SRP14; RPS27L; RPS17; RPS2; RPL13; RPL23A; RPL19; RPL27; ASNA1; RPS19; RPL13A; RPS5
GO:0016072	rRNA metabolic process	2.88	5.49e-09	1.34e-06	35/171	RPF1; RPS7; WDR43; MRPS9; NIFK; RPSA; EXOSC7; RRP9; ABT1; RPL7L1; DDX56; WBSCR22; DCAF13; EXOSC4; RPS6; WDR74; TRMT112; GTPBP4; DDX21; EXOSC1; NPM3; KRR1; EXOSC8; NGDN; RPS27L; RPS17; MRPS11; RPS2; RSL1D1; NOB1; DDX52; RPL27; EIF4A3; C19orf43; RPS19
GO:0006413	translational initiation	2.60	1.19e-06	1.09e-04	29/157	EIF3I; RPS7; RPS27A; RPSA; RPL9; RPL37; RPS10; RPS12; HSPB1; RPL10; COPS5; RPS6; CDC123; RPL41; RPS29; RPS27L; RPS17; RPS2; RPL13; EIF4A1; RPL23A; RPL19; EIF1; RPL27; EIF6; RPS19; RPL13A; RPS5; ATF4
GO:0090150	establishment of protein localization to membrane	2.42	5.72e-07	5.99e-05	35/204	ATP1B1; RPS7; RPS27A; REEP1; C2orf47; RPSA; SEC62; NSG1; RPL9; RPL37; RPS10; CD24; RPS12; RPL10; YWHAZ; RPS6; ANK3; RPL41; RPS29; SRP14; RPS27L; RPS17; RPS2; RAB26; RPL13; RPL23A; RPL19; RPL27; RAB31; ASNA1; RAB8A; RPS19; RPL13A; RPS5; TOMM22
GO:0032984	protein-containing complex disassembly	2.40	4.49e-07	5.49e-05	36/211	PEX14; STMN1; MRPL37; MRPL9; MRPS9; MRPS22; MRPL47; MRPS18C; MRPS30; MRPL22; MRPS18B; MRPS10; MRPL2; MRPS18A; MRPL32; STMN4; MRPL15; STMN2; MRPL50; SPTAN1; MRPS2; MRPL21; MRPL51; MRPL42; KLC1; MRPL46; MRPS11; MRPS34; MRPL27; ICT1; MRPS7; MRPL12; MRPS26; DSTN; GADD45GIP1; MRPL39
GO:0034470	ncRNA processing	2.21	4.87e-06	3.97e-04	35/223	RPF1; RPS7; WDR43; MRPS9; RPSA; EXOSC7; RRP9; ABT1; RPL7L1; DDX56; WBSCR22; DCAF13; EXOSC4; RPS6; WDR74; TRMT112; GTPBP4; DDX21; EXOSC1; NPM3; KRR1; EXOSC8; NGDN; RPS27L; RPS17; MRPS11; RPS2; RSL1D1; NOB1; DDX52; RPL27; EIF4A3; TP53RK; RPS19; TRMU
GO:0022613	ribonucleoprotein complex biogenesis	2.18	4.34e-08	7.96e-06	51/330	EIF3I; RPF1; RPS7; WDR43; CEBPZ; MRPS9; LSM3; RPSA; EXOSC7; RRP9; BRIX1; MRPL22; ABT1; RPS10; RPL7L1; DDX56; WBSCR22; RPL10; DCAF13; EXOSC4; RPS6; MRPS2; WDR74; TRMT112; GTPBP4; DDX21; EXOSC1; NPM3; KRR1; RAN; EXOSC8; PRMT5; NGDN; RPS27L; RPS17; MRPS11; RPS2; RSL1D1; NOB1; RPL23A; DDX52; RPL27; MRPS7; EIF4A3; CELF4; SNRPB; EIF6; RPS19; RPL13A; RPS5
GO:0006401	RNA catabolic process	2.09	1.76e-05	1.18e-03	35/236	YBX1; SERBP1; RBM8A; RPS7; RPS27A; LSM3; RPSA; EXOSC7; RPL9; RPL37; RPS10; RPS12; HSPB1; RPL10; YWHAZ; EXOSC4; RPS6; EXOSC1; RPL41; EXOSC8; RPS29; SLIRP; RPS27L; RPS17; RPS2; RPL13; RPL23A; RPL19; RPL27; EIF4A3; LSM7; C19orf43; RPS19; RPL13A; RPS5
GO:0006605	protein targeting	2.05	1.17e-05	8.57e-04	38/261	PEX14; TIMM17A; RPS7; RPS27A; RPSA; SEC62; PARL; RPL9; RPL37; RPS10; RPS12; RPL10; YWHAZ; RPS6; PMPCA; SPCS2; ANK3; RPL41; AKAP6; RPS29; SRP14; RPS27L; RPS17; RPS2; RPL13; RPL23A; RPL19; RPL27; TIMM44; UBL5; ASNA1; TIMM50; RPS19; RPL13A; RPS5; UBE2L3; TOMM22; TSPO
GO:0009141	nucleoside triphosphate metabolic process	2.01	3.13e-04	1.92e-02	27/189	NDUFS2; ATP1B1; COX5B; NDUFB5; SNCA; NDUFS6; NDUFS4; COX7C; COX7A2; NDUFA4; TMSB4X; CYC1; NDUFS3; SDHD; NDUFA9; GAPDH; ATP5B; NDUFA12; COX6A1; RAN; NDUFB10; EIF6; ATP5E; SIRT6; UQCRFS1; TSPO; ATP5O

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Factor 2 : 44 significant GO terms

GeneSet	description	enrichRatio	pValue	FDR	GeneRatio	geneSymbols
GO:0070972	protein localization to endoplasmic reticulum	8.81	0.00e+00	0.00e+00	84/119	RPL22; RPL11; RPS8; RPL5; RPS27; SRP9; RPS7; RTN4; RPS27A; RPL31; RPL37A; RPL32; RPL15; RPSA; RPL14; RPL29; RPL24; RPL35A; RPL9; RPL34; RPS3A; RPL37; RPS23; RPS14; RPS18; RPS10; RPL10A; RPS12; RPS4X; RPL36A; RPL39; BCAP31; RPL10; RPS20; RPL7; RPL30; GPAA1; RPL8; RPS6; RPL35; RPL12; RPL7A; RPLP2; RPL27A; RPS13; SPCS2; RPS3; RPS25; RPS24; RPL41; RPL6; RPLP0; RPL21; RPS29; SRP14; RPL4; RPLP1; RPS17; RPS2; RPS15A; RPL13; RPL26; RPL23A; RPL23; RPL19; RPL27; RPL38; VAPA; DDRGK1; RPS21; RPS15; RPL36; RPS28; RPL18A; UBA52; RPS16; RPS19; RPL18; RPL13A; RPS11; RPS9; RPL28; RPS5; RPL3
GO:0006413	translational initiation	6.60	0.00e+00	0.00e+00	83/157	RPL22; RPL11; RPS8; RPL5; RPS27; RPS7; RPS27A; RPL31; RPL37A; RPL32; RPL15; RPSA; RPL14; RPL29; RPL24; EIF4A2; RPL35A; RPL9; RPL34; RPS3A; RPL37; RPS23; RPS14; RPS18; RPS10; RPL10A; RPS12; RPS4X; RPL36A; RPL39; MCTS1; RPL10; RPS20; RPL7; RPL30; PABPC1; RPL8; RPS6; RPL35; RPL12; RPL7A; RPLP2; RPL27A; RPS13; PPP1CA; RPS3; RPS25; CDC123; RPS24; RPL41; RPL6; RPLP0; RPL21; RPS29; RPL4; RPLP1; RPS17; RPS2; RPS15A; RPL13; EIF4A1; RPL26; RPL23A; RPL23; RPL19; EIF1; RPL27; RPL38; RPS21; RPS15; RPL36; RPS28; RPL18A; UBA52; RPS16; RPS19; RPL18; RPL13A; RPS11; RPS9; RPL28; RPS5; RPL3
GO:0070670	response to interleukin-4	5.67	9.91e-04	2.20e-02	5/11	HSP90AB1; TUBA1B; CORO1A; XBP1; RPL3
GO:0090150	establishment of protein localization to membrane	5.45	0.00e+00	0.00e+00	89/204	RPL22; RPL11; RPS8; RPL5; RPS27; SRP9; RPS7; YWHAQ; RPS27A; RPL31; RPL37A; RPL32; RPL15; RPSA; RPL14; RPL29; RPL24; RPL35A; NSG1; RPL9; RPL34; RPS3A; RPL37; RPS23; RPS14; GNB2L1; RPS18; RPS10; RPL10A; RPS12; RPS4X; RPL36A; RPL39; RPL10; RPS20; SDCBP; RPL7; RPL30; RPL8; RPS6; RPL35; RPL12; RPL7A; RPLP2; RPL27A; RPS13; RPS3; RPS25; RPS24; RPL41; RPL6; RPLP0; RPL21; RPS29; CALM1; HSP90AA1; SRP14; RPL4; RPLP1; RPS17; RPS2; RPS15A; ARL6IP1; RPL13; YWHAE; RPL26; RPL23A; RPL23; RPL19; RPL27; RPL38; YWHAB; RPS21; RPS15; RPL36; RPS28; RPL18A; UBA52; NDUFA13; RPS16; RPS19; RPL18; RPL13A; RPS11; RPS9; RPL28; RPS5; RPL3; WRB
GO:0002181	cytoplasmic translation	5.30	5.55e-16	6.79e-14	31/73	RPL11; RPL31; RPL32; RPL15; TMA7; RPL29; RPL24; RPL35A; RPL9; RPS23; RPL10A; RPL36A; RPL39; MCTS1; RPL30; RPL8; RPL41; RPL6; RPLP0; RPS29; RPLP1; RPL26; RPL19; RPL38; RPS21; EEF2; RPL36; RPS28; RPL18A; RPL18; RPL13A
GO:0006401	RNA catabolic process	4.44	0.00e+00	0.00e+00	84/236	RPL22; RPL11; RPS8; RPL5; RPS27; RPS7; RPS27A; RPL31; SSB; RPL37A; RPL32; RPL15; RPSA; RPL14; RPL29; RPL24; RPL35A; RPL9; RPL34; RPS3A; RPL37; RPS23; RPS14; RPS18; RPS10; RPL10A; RPS12; RPS4X; RPL36A; RPL39; RPL10; RPS20; RPL7; RPL30; PABPC1; RPL8; RPS6; RPL35; RPL12; SET; RPL7A; RNH1; RPLP2; RPL27A; RPS13; RPS3; RPS25; HSPA8; RPS24; RPL41; RPL6; RPLP0; UBC; RPL21; RPS29; RPL4; RPLP1; RPS17; RPS2; RPS15A; RPL13; RPL26; RPL23A; RPL23; RPL19; RPL27; RPL38; EIF4A3; YWHAB; RPS21; RPS15; RPL36; RPS28; RPL18A; UBA52; RPS16; RPS19; RPL18; RPL13A; RPS11; RPS9; RPL28; RPS5; RPL3
GO:0006605	protein targeting	4.26	0.00e+00	0.00e+00	89/261	RPL22; RPL11; RPS8; RPL5; RPS27; SRP9; RPS7; RPS27A; RPL31; RPL37A; RPL32; RPL15; RPSA; RPL14; RPL29; RPL24; RAB7A; RPL35A; RPL9; RPL34; RPS3A; RPL37; RPS23; RPS14; RPS18; RPS10; RPL10A; RPS12; RPS4X; RPL36A; RPL39; RPL10; RPS20; SDCBP; RPL7; RPL30; RPL8; RPS6; RPL35; RPL12; RPL7A; RPLP2; RPL27A; RPS13; SPCS2; RPS3; RPS25; HSPA8; RPS24; RPL41; RPL6; RPLP0; UBC; RPL21; RPS29; HSP90AA1; SRP14; RPL4; RPLP1; RPS17; RPS2; RPS15A; ARL6IP1; UQCRC2; RPL13; RPL26; RPL23A; RPL23; RPL19; RPL27; RPL38; YWHAB; RPS21; RPS15; RPL36; RPS28; RPL18A; UBA52; NDUFA13; ECH1; RPS16; RPS19; RPL18; RPL13A; RPS11; RPS9; RPL28; RPS5; RPL3
GO:0051187	cofactor catabolic process	4.16	2.06e-03	3.02e-02	6/18	ACOT7; PRDX1; BLVRA; PRDX4; PRDX5; PRDX2
GO:0052192	movement in environment of other organism involved in symbiotic interaction	4.16	2.06e-03	3.02e-02	6/18	RAB7A; PPIA; TSG101; SMC3; VAPA; CHMP2A
GO:0006081	cellular aldehyde metabolic process	4.16	1.58e-04	5.80e-03	9/27	PARK7; AKR7A2; TKT; TALDO1; AKR1C1; PGAM1; TPI1; ESD; IDH2
GO:0001906	cell killing	4.01	2.16e-04	6.91e-03	9/28	PRDX1; TUBB; HSP90AB1; RPL30; TUBB4B; GAPDH; CORO1A; RPS19; PVRL2
GO:0070671	response to interleukin-12	3.87	2.92e-04	8.93e-03	9/29	CDC42; HNRNPA2B1; RALA; PPIA; TALDO1; CFL1; RPLP0; PSME2; SOD1
GO:0002576	platelet degranulation	3.81	7.26e-05	3.14e-03	11/36	TAGLN2; TUBA4A; MAGED2; APLP2; PSAP; CD63; CALM1; SCG3; ALDOA; LGALS3BP; SOD1
GO:1902579	multi-organism localization	3.74	3.74e-03	4.91e-02	6/20	RPS27A; RAB7A; DYNLT1; UBC; RAN; UBA52
GO:0016999	antibiotic metabolic process	3.66	1.51e-06	1.23e-04	17/58	PARK7; AKR7A2; PRDX1; MDH1; SUCLG1; PDHB; MDH2; AKR1B1; PDHA1; PRDX4; PRDX5; AKR1C1; ALDH2; ESD; IDH2; PRDX2; SOD1
GO:0048857	neural nucleus development	3.62	5.09e-04	1.38e-02	9/31	CDC42; ATP5F1; YWHAQ; ACTB; DYNLL1; CALM1; CKB; YWHAE; ATP5J
GO:0006090	pyruvate metabolic process	3.57	1.78e-05	9.80e-04	14/49	ENO1; PDHB; VDAC1; PDHA1; PGK1; LDHA; PGAM1; GAPDH; TPI1; LDHB; PKM; ALDOA; ENO3; BSG
GO:0099132	ATP hydrolysis coupled cation transmembrane transport	3.51	6.59e-04	1.73e-02	9/32	ATP6V0B; ATP5F1; ATP5G3; ATP6AP1; ATP5C1; ATP5B; ATP6V0D1; ATP5A1; ATP5O
GO:0072524	pyridine-containing compound metabolic process	3.22	1.87e-05	9.80e-04	16/62	ENO1; MDH1; TKT; PDHB; MDH2; PDHA1; PGK1; TALDO1; LDHA; PGAM1; GAPDH; TPI1; PKM; IDH2; ALDOA; ENO3
GO:0008037	cell recognition	3.12	1.66e-03	2.94e-02	9/36	RTN4; CCT7; GAP43; CCT5; VDAC2; CCT2; ALDOA; CORO1A; BSG
GO:0030901	midbrain development	3.12	9.24e-04	2.19e-02	10/40	CDC42; ATP5F1; YWHAQ; CTNNB1; ACTB; DYNLL1; CALM1; CKB; YWHAE; ATP5J
GO:0009566	fertilization	3.04	2.04e-03	3.02e-02	9/37	PARK7; H3F3A; CCT7; CCT5; VDAC2; CCT2; REC8; ALDOA; PVRL2
GO:0005996	monosaccharide metabolic process	2.87	1.14e-05	6.99e-04	20/87	ENO1; MDH1; TKT; PDHB; MDH2; AKR1B1; PDHA1; PGK1; TALDO1; PPP1CA; PGAM1; GAPDH; TPI1; HMGB1; PKM; VIMP; ALDOA; ENO3; G6PC3; CYB5R3
GO:0035821	modification of morphology or physiology of other organism	2.86	1.14e-03	2.38e-02	11/48	RPL30; RRAGA; CFL1; HSPA8; SMC3; GAPDH; CALM1; PPIB; KPNA2; VAPA; RPS19
GO:0046939	nucleotide phosphorylation	2.84	2.02e-03	3.02e-02	10/44	ENO1; SUCLG1; PGK1; LDHA; PGAM1; GAPDH; TPI1; PKM; ALDOA; ENO3
GO:0016052	carbohydrate catabolic process	2.75	1.62e-03	2.94e-02	11/50	ENO1; PGK1; LDHA; PPP1CA; PGAM1; GAPDH; TPI1; HMGB1; PKM; ALDOA; ENO3
GO:0045861	negative regulation of proteolysis	2.73	6.01e-06	4.01e-04	23/105	PARK7; RPL11; TMEM59; RPL5; AGT; RPS7; SERPINI1; HSP90AB1; SDCBP; PRDX5; APLP2; GAPDH; PEBP1; MAP1A; ARL6IP1; HERPUD1; GABARAPL2; YWHAE; SERPINF1; RPL23; DDRGK1; CST3; CDKN2D
GO:0016051	carbohydrate biosynthetic process	2.64	3.88e-04	1.14e-02	15/71	ENO1; MDH1; TKT; MDH2; AKR1B1; PGK1; TALDO1; PPP1CA; PGAM1; GAPDH; TPI1; VIMP; ALDOA; ENO3; G6PC3
GO:0036230	granulocyte activation	2.55	2.48e-08	2.60e-06	39/191	DDOST; PSMA5; ILF2; ARPC5; PSMD6; RAB7A; TUBB; CSNK2B; HSP90AB1; DYNLT1; PSMB1; PPIA; PSMC2; PRDX4; ATP6AP2; SDCBP; GGH; TUBB4B; PSMD13; GSTP1; NDUFC2; HSPA8; PSAP; PGAM1; CD63; CCT2; DYNLL1; HMGB1; ACTR10; HSP90AA1; SRP14; PKM; ALDOA; PSMD7; VAPA; CST3; EEF2; FTL; CYB5R3
GO:0002446	neutrophil mediated immunity	2.52	3.35e-08	3.07e-06	39/193	DDOST; PSMA5; ILF2; ARPC5; PSMD6; RAB7A; TUBB; CSNK2B; HSP90AB1; DYNLT1; PSMB1; PPIA; PSMC2; PRDX4; ATP6AP2; SDCBP; GGH; TUBB4B; PSMD13; GSTP1; NDUFC2; HSPA8; PSAP; PGAM1; CD63; CCT2; DYNLL1; HMGB1; ACTR10; HSP90AA1; SRP14; PKM; ALDOA; PSMD7; VAPA; CST3; EEF2; FTL; CYB5R3
GO:0006909	phagocytosis	2.46	1.24e-03	2.53e-02	14/71	CDC42; ARPC5; ARPC2; RAB7A; LMAN2; GNB2L1; HSP90AB1; ACTB; ARPC1A; ARPC3; HMGB1; HSP90AA1; CORO1A; ACTG1
GO:1902600	proton transmembrane transport	2.43	9.58e-04	2.20e-02	15/77	PARK7; ATP6V0B; ATP5F1; ATP5G3; NDUFA4; ATP6AP1; COX6C; ATP5C1; ATP5B; SLC25A3; COX5A; ATP6V0D1; ATP5A1; ATP5J; ATP5O
GO:0009410	response to xenobiotic stimulus	2.33	2.15e-03	3.10e-02	14/75	AKR7A2; GSTM3; PHGDH; MGST3; EPHX1; CDO1; HSP90AB1; GSTA4; GSTP1; AKR1C1; PTGES3; CALM1; SERPINF1; SOD1
GO:0019058	viral life cycle	2.32	1.96e-04	6.53e-03	21/113	CDC42; RPS27A; RAB1A; RPSA; RAB7A; HSP90AB1; DYNLT1; PPIA; PABPC1; CHMP5; TSG101; HSPA8; SMC3; UBC; RAN; PPIB; HACD3; VAPA; UBA52; PVRL2; CHMP2A
GO:0052547	regulation of peptidase activity	2.28	1.30e-04	5.29e-03	23/126	PARK7; AGT; ARL6IP5; SERPINI1; GNB2L1; CYCS; BCAP31; PRDX5; RPS3; APLP2; GAPDH; PEBP1; HMGB1; PSME2; PSMA3; ARL6IP1; HERPUD1; YWHAE; SERPINF1; DDRGK1; CST3; CDKN2D; NDUFA13
GO:0070646	protein modification by small protein removal	2.25	5.75e-05	2.64e-03	26/144	PARK7; PSMA5; PSMD4; RPS27A; COPS8; PSMD6; UCHL1; PSMB1; ACTB; COPS6; PSMC2; PSMD13; UBC; PSME2; PSMA3; PSMA4; PSMD7; PSMB6; COPS3; PSMB3; PSMC5; PSMA7; UBA52; PSMD8; PSMC4; UFD1L
GO:0071897	DNA biosynthetic process	2.23	2.39e-03	3.38e-02	15/84	RPS27A; CCT7; CTNNB1; CCT5; HSP90AB1; HNRNPA2B1; PPIA; PTGES3; CCT2; UBC; HSP90AA1; TERF2IP; CDKN2D; UBA52; UFD1L
GO:0043687	post-translational protein modification	2.19	3.62e-05	1.77e-03	29/165	PSMA5; PSMD4; PDIA6; RAB1A; COPS8; PSMD6; SKP1; PSMB1; COPS6; PSMC2; RAB2A; TCEB1; PSMD13; APLP2; HSP90B1; PSME2; PSMA3; SCG3; PPIB; PSMA4; PSMD7; PSMB6; COPS3; PSMB3; PSMC5; CST3; PSMA7; PSMD8; PSMC4
GO:0072593	reactive oxygen species metabolic process	2.18	3.04e-03	4.13e-02	15/86	PARK7; PRDX1; GADD45A; AGT; ARF4; DDAH2; HSP90AB1; PRDX4; PRDX5; GSTP1; HSP90AA1; VIMP; PRDX2; NDUFA13; SOD1
GO:0006091	generation of precursor metabolites and energy	2.11	1.67e-06	1.23e-04	42/248	PARK7; ENO1; AKR7A2; ATP5F1; PHGDH; MDH1; SUCLG1; UQCRC1; PDHB; SLC25A4; NDUFA4; CYCS; MDH2; AKR1B1; PDHA1; PGK1; COX6C; NDUFB6; LDHA; PPP1CA; NDUFV1; NDUFC2; ATP5C1; PGAM1; NDUFB8; GAPDH; TPI1; ATP5B; ALDH2; HMGB1; PKM; COX5A; IDH2; VIMP; UQCRC2; ALDOA; ENO3; NDUFV2; ATP5A1; ETFB; ATP5J; ATP5O
GO:0031098	stress-activated protein kinase signaling cascade	2.10	2.45e-03	3.39e-02	17/101	CDC42; PRDX1; GADD45A; AGT; RPS27A; ARL6IP5; SKP1; AKR1B1; SDCBP; DNAJA1; GSTP1; RPS3; UBC; HMGB1; HACD3; UBA52; PRMT1
GO:2001233	regulation of apoptotic signaling pathway	2.07	1.45e-04	5.59e-03	28/169	PARK7; ENO1; RPL11; MLLT11; AGT; RPS7; YWHAQ; ITM2C; CTNNB1; GNB2L1; BCAP31; DNAJA1; PPP1CA; GSTP1; RPS3; VDAC2; TMBIM6; TPT1; PDIA3; VIMP; HERPUD1; YWHAE; RPL26; YWHAB; CDKN2D; NDUFA13; XBP1; SOD1
GO:0046390	ribose phosphate biosynthetic process	2.01	1.80e-03	3.00e-02	20/124	ACOT7; ENO1; ATP5F1; ATP5G3; PDHB; PDHA1; PGK1; LDHA; ATP5C1; PGAM1; GAPDH; TPI1; ATP5B; PKM; ALDOA; ENO3; ATP5A1; TECR; ATP5J; ATP5O
GO:1901615	organic hydroxy compound metabolic process	2.01	1.80e-03	3.00e-02	20/124	PARK7; AKR7A2; FDPS; ACAT2; AKR1B1; EBP; NSDHL; FDFT1; LDHA; TM7SF2; DHCR7; AKR1C1; TPI1; PMEL; ALDH2; RAN; CALM1; PLTP; CYB5R3; SOD1

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Factor 3 : 12 significant GO terms

GeneSet	description	enrichRatio	pValue	FDR	GeneRatio	geneSymbols
GO:0070972	protein localization to endoplasmic reticulum	38.40	0.00e+00	0.00e+00	66/119	RPL11; RPS8; RPL5; RPS27; RPS7; RPS27A; RPL31; RPL37A; RPL32; RPL15; RPL14; RPL29; RPL24; RPL35A; RPL9; RPL34; RPS3A; RPL37; RPS23; RPS14; RPS18; RPL10A; RPS12; RPS4X; RPL36A; RPL39; RPL10; RPS20; RPL7; RPL30; RPS6; RPL35; RPL12; RPL7A; RPLP2; RPL27A; RPS13; RPS3; RPS25; RPS24; RPL41; RPL6; RPLP0; RPL21; RPLP1; RPS17; RPS15A; RPL13; RPL26; RPL23; RPL19; RPL38; RPS21; RPS15; RPL36; RPS28; RPL18A; RPS16; RPS19; RPL18; RPL13A; RPS11; RPS9; RPL28; RPS5; RPL3
GO:0006413	translational initiation	29.10	0.00e+00	0.00e+00	66/157	RPL11; RPS8; RPL5; RPS27; RPS7; RPS27A; RPL31; RPL37A; RPL32; RPL15; RPL14; RPL29; RPL24; RPL35A; RPL9; RPL34; RPS3A; RPL37; RPS23; RPS14; RPS18; RPL10A; RPS12; RPS4X; RPL36A; RPL39; RPL10; RPS20; RPL7; RPL30; RPS6; RPL35; RPL12; RPL7A; RPLP2; RPL27A; RPS13; RPS3; RPS25; RPS24; RPL41; RPL6; RPLP0; RPL21; RPLP1; RPS17; RPS15A; RPL13; RPL26; RPL23; RPL19; RPL38; RPS21; RPS15; RPL36; RPS28; RPL18A; RPS16; RPS19; RPL18; RPL13A; RPS11; RPS9; RPL28; RPS5; RPL3
GO:0002181	cytoplasmic translation	24.70	0.00e+00	0.00e+00	26/73	RPL11; RPL31; RPL32; RPL15; RPL29; RPL24; RPL35A; RPL9; RPS23; RPL10A; RPL36A; RPL39; RPL30; RPL41; RPL6; RPLP0; RPLP1; RPL26; RPL19; RPL38; RPS21; RPL36; RPS28; RPL18A; RPL18; RPL13A
GO:0090150	establishment of protein localization to membrane	22.70	0.00e+00	0.00e+00	67/204	RPL11; RPS8; RPL5; RPS27; RPS7; RPS27A; RPL31; RPL37A; RPL32; RPL15; RPL14; RPL29; RPL24; RPL35A; RPL9; RPL34; RPS3A; RPL37; RPS23; RPS14; GNB2L1; RPS18; RPL10A; RPS12; RPS4X; RPL36A; RPL39; RPL10; RPS20; RPL7; RPL30; RPS6; RPL35; RPL12; RPL7A; RPLP2; RPL27A; RPS13; RPS3; RPS25; RPS24; RPL41; RPL6; RPLP0; RPL21; RPLP1; RPS17; RPS15A; RPL13; RPL26; RPL23; RPL19; RPL38; RPS21; RPS15; RPL36; RPS28; RPL18A; RPS16; RPS19; RPL18; RPL13A; RPS11; RPS9; RPL28; RPS5; RPL3
GO:0006401	RNA catabolic process	19.40	0.00e+00	0.00e+00	66/236	RPL11; RPS8; RPL5; RPS27; RPS7; RPS27A; RPL31; RPL37A; RPL32; RPL15; RPL14; RPL29; RPL24; RPL35A; RPL9; RPL34; RPS3A; RPL37; RPS23; RPS14; RPS18; RPL10A; RPS12; RPS4X; RPL36A; RPL39; RPL10; RPS20; RPL7; RPL30; RPS6; RPL35; RPL12; RPL7A; RPLP2; RPL27A; RPS13; RPS3; RPS25; RPS24; RPL41; RPL6; RPLP0; RPL21; RPLP1; RPS17; RPS15A; RPL13; RPL26; RPL23; RPL19; RPL38; RPS21; RPS15; RPL36; RPS28; RPL18A; RPS16; RPS19; RPL18; RPL13A; RPS11; RPS9; RPL28; RPS5; RPL3
GO:0006605	protein targeting	17.80	0.00e+00	0.00e+00	67/261	RPL11; RPS8; RPL5; RPS27; RPS7; RPS27A; RPL31; RPL37A; RPL32; RPL15; RPL14; RPL29; RPL24; RPL35A; RPL9; RPL34; RPS3A; RPL37; RPS23; RPS14; RPS18; RPL10A; RPS12; SLC25A6; RPS4X; RPL36A; RPL39; RPL10; RPS20; RPL7; RPL30; RPS6; RPL35; RPL12; RPL7A; RPLP2; RPL27A; RPS13; RPS3; RPS25; RPS24; RPL41; RPL6; RPLP0; RPL21; RPLP1; RPS17; RPS15A; RPL13; RPL26; RPL23; RPL19; RPL38; RPS21; RPS15; RPL36; RPS28; RPL18A; RPS16; RPS19; RPL18; RPL13A; RPS11; RPS9; RPL28; RPS5; RPL3
GO:0016072	rRNA metabolic process	8.91	6.66e-16	6.11e-14	22/171	RPL11; RPS8; RPL5; RPS27; RPS7; RPL14; RPL35A; RPS14; RPL10A; RPL7; RPS6; RPL35; RPL7A; RPS24; RPS17; RPL26; RPS21; RPS15; RPS28; RPS16; RPS19; RPS9
GO:0034470	ncRNA processing	6.83	1.73e-13	1.41e-11	22/223	RPL11; RPS8; RPL5; RPS27; RPS7; RPL14; RPL35A; RPS14; RPL10A; RPL7; RPS6; RPL35; RPL7A; RPS24; RPS17; RPL26; RPS21; RPS15; RPS28; RPS16; RPS19; RPS9
GO:0022613	ribonucleoprotein complex biogenesis	6.72	0.00e+00	0.00e+00	32/330	RPL11; RPS8; RPL5; RPS27; RPS7; RPL14; RPL24; RPL35A; RPS23; RPS14; RPL10A; RPL10; RPL7; RPS6; RPL35; RPL12; RPL7A; RPS24; RPL6; RPLP0; RPS17; RPL26; RPL38; RPS21; RPS15; RPS28; RPS16; RPS19; RPL13A; RPS9; RPS5; RPL3
GO:0071826	ribonucleoprotein complex subunit organization	6.37	5.08e-10	3.73e-08	17/185	RPL11; RPL5; RPS27; RPL24; RPS23; RPS14; RPL10; RPL12; RPL6; RPLP0; RPL38; RPS15; RPS28; RPS19; RPL13A; RPS5; RPL3
GO:0034248	regulation of cellular amide metabolic process	3.36	3.50e-04	2.34e-02	11/227	RPL5; RPS14; GNB2L1; SOX4; RPS4X; RPL10; RPS3; RPL26; RPL38; RPL13A; RPS9
GO:0010608	posttranscriptional regulation of gene expression	2.91	6.88e-04	4.21e-02	12/286	RPL5; RPS27A; RPS14; GNB2L1; SOX4; RPS4X; RPL10; RPS3; RPL26; RPL38; RPL13A; RPS9

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Factor 4 : 56 significant GO terms

GeneSet	description	enrichRatio	pValue	FDR	GeneRatio	geneSymbols
GO:0015844	monoamine transport	7.56	1.60e-05	1.07e-03	7/17	SYT11; AGT; SNCA; ACTB; STX1A; GPM6B; SYT7
GO:0007218	neuropeptide signaling pathway	7.34	1.39e-03	2.81e-02	4/10	PCSK1N; GAL; SSTR2; PTH2
GO:0010644	cell communication by electrical coupling	7.06	4.15e-04	1.17e-02	5/13	ATP1B1; RYR2; SRI; ANK3; CALM1
GO:0010737	protein kinase A signaling	6.67	2.10e-03	3.29e-02	4/11	RAB13; AKAP12; EZR; GAL
GO:0034109	homotypic cell-cell adhesion	6.12	2.64e-04	7.74e-03	6/18	CLIC1; ACTB; ILK; ANK3; ACTG1; MYL12A
GO:0031644	regulation of neurological system process	5.51	1.93e-05	1.18e-03	9/30	PRKCZ; AGT; NRXN1; STX1A; AKAP9; CBLN1; EIF4A3; BAIAP2; CELF4
GO:0099565	chemical synaptic transmission, postsynaptic	5.24	1.07e-05	7.82e-04	10/35	PRKCZ; NRXN1; CHRNA1; SNCA; MEF2C; STX1A; CBLN1; EIF4A3; BAIAP2; CELF4
GO:0060191	regulation of lipase activity	4.83	2.86e-03	3.89e-02	5/19	PRKCZ; HPCA; RHOC; AGT; SNCA
GO:0015837	amine transport	4.59	3.65e-03	4.62e-02	5/20	SYT11; AGT; SNCA; STX1A; SYT7
GO:0035637	multicellular organismal signaling	4.27	7.54e-05	3.46e-03	10/43	ATP1B1; AGT; RYR2; SCN3A; SCN9A; CHRNA1; SRI; AKAP9; ANK3; CALM1
GO:0010959	regulation of metal ion transport	4.26	1.55e-09	7.02e-07	23/99	SEPN1; HPCA; NOS1AP; ATP1B1; AGT; RYR2; GNAI2; SNCA; TSPAN13; CAMK2B; SRI; AKAP9; G6PD; CHD7; GAL; ANK3; CD63; JPH4; CALM1; FKBP1A; NKAIN4; HOMER3; FXYD7
GO:0034765	regulation of ion transmembrane transport	3.92	1.91e-09	7.02e-07	25/117	SEPN1; HPCA; NOS1AP; ATP1B1; AGT; RYR2; SCN3A; SCN9A; SNCA; MEF2C; CLIC1; TSPAN13; SRI; AKAP9; TMSB4X; G6PD; CHD7; GAL; ANK3; CD63; JPH4; CALM1; FKBP1A; CACNA1A; FXYD7
GO:0048771	tissue remodeling	3.89	1.66e-03	3.04e-02	7/33	AGT; IGFBP5; MEF2C; CHD7; CTHRC1; SYT7; CST3
GO:0032409	regulation of transporter activity	3.85	1.08e-06	1.33e-04	17/81	SEPN1; HPCA; NOS1AP; ATP1B1; RYR2; SNCA; MEF2C; ACTB; SRI; AKAP9; TMSB4X; GAL; ANK3; JPH4; CALM1; FKBP1A; FXYD7
GO:0014074	response to purine-containing compound	3.76	9.82e-04	2.19e-02	8/39	SEPN1; RYR2; IGFBP5; HDAC2; EZR; AKAP9; RAPGEF1; BSG
GO:0008277	regulation of G protein-coupled receptor signaling pathway	3.67	5.80e-04	1.42e-02	9/45	STMN1; RGS16; GNG4; GNAI2; SNCA; DYNLT1; RGS10; CALM1; APLP1
GO:0098742	cell-cell adhesion via plasma-membrane adhesion molecules	3.67	1.17e-03	2.53e-02	8/40	PTPRF; NRXN1; PTPRG; ALCAM; MDGA1; PCDH9; CBLN1; BSG
GO:0034764	positive regulation of transmembrane transport	3.61	4.23e-05	2.22e-03	13/66	NOS1AP; ATP1B1; AGT; RYR2; CAPN10; SNCA; SRI; AKAP9; TMSB4X; G6PD; GAL; ANK3; CALM1
GO:0003205	cardiac chamber development	3.51	8.10e-04	1.92e-02	9/47	LMO4; RYR2; SOX11; ID2; NRP2; MEF2C; FZD1; CHD7; FKBP1A
GO:0033002	muscle cell proliferation	3.26	2.59e-03	3.73e-02	8/45	SEPN1; AGT; ID2; IGFBP5; GNAI2; MEF2C; ILK; GSTP1
GO:0043270	positive regulation of ion transport	3.24	2.51e-04	7.69e-03	12/68	NOS1AP; ATP1B1; AGT; RYR2; SNCA; SRI; AKAP9; TMSB4X; G6PD; GAL; ANK3; CALM1
GO:0015850	organic hydroxy compound transport	3.24	1.49e-03	2.81e-02	9/51	SYT11; AGT; SNCA; ACTB; STX1A; GPM6B; SYT7; GAL; SELM
GO:0042391	regulation of membrane potential	3.21	1.41e-06	1.48e-04	21/120	PRKCZ; NOS1AP; ATP1B1; RYR2; NRXN1; SCN3A; SCN9A; CHRNA1; SNCA; MEF2C; CLIC1; HEBP2; STX1A; SRI; AKAP9; ANK3; CBLN1; EIF4A3; BAIAP2; CELF4; CACNA1A
GO:0001764	neuron migration	3.20	5.00e-04	1.31e-02	11/63	ACAP3; NAV1; NRP2; DNER; GPM6A; MEF2C; TUBB2B; MDGA1; CAMK2B; AUTS2; NEUROD4
GO:0019932	second-messenger-mediated signaling	3.19	2.86e-05	1.62e-03	16/92	SEPN1; HPCA; NOS1AP; ATP1B1; AGT; RYR2; NEUROD1; GNAI2; SRI; GAL; JPH4; CALM1; FKBP1A; HOMER3; APLP1; PDE9A
GO:0009410	response to xenobiotic stimulus	3.18	1.68e-04	5.88e-03	13/75	SEPN1; HPCA; EPHX1; RYR2; GPX1; SNCA; NR3C1; HSP90AB1; HDAC2; GSTP1; RGS10; CALM1; SERPINF1
GO:0003007	heart morphogenesis	3.15	5.75e-04	1.42e-02	11/64	GNG5; RYR2; SOX11; ID2; NRP2; MEF2C; FZD1; CHD7; ILK; ACTC1; FKBP1A
GO:0099177	regulation of trans-synaptic signaling	3.14	1.19e-07	2.18e-05	26/152	PRKCZ; SYT11; AGT; NRXN1; GNAI2; NSG1; SNCA; MEF2C; CPLX2; TUBB2B; GRM4; AKAP12; CAMK2B; STX1A; AKAP9; SYT7; JPH4; CALM1; RAB26; CBLN1; EFNB3; EIF4A3; BAIAP2; CELF4; CACNA1A; RAB3A
GO:0001818	negative regulation of cytokine production	3.12	3.44e-03	4.43e-02	8/47	SYT11; BTN2A2; HSP90AB1; EZR; TMSB4X; UBE2L6; GSTP1; HOMER3
GO:0003012	muscle system process	3.11	7.35e-06	6.74e-04	19/112	NOS1AP; ATP1B1; AGT; RYR2; CHRNA1; MYL1; IGFBP5; MEF2C; HDAC2; CAMK2B; SRI; CALD1; G6PD; MYL6; CALM1; ACTC1; SSTR2; MYL12A; PDE9A
GO:0072511	divalent inorganic cation transport	3.06	9.60e-06	7.82e-04	19/114	SEPN1; HPCA; NOS1AP; ATP1B1; AGT; RYR2; GNAI2; SNCA; GPM6A; TSPAN13; CAMK2B; SRI; G6PD; CHD7; JPH4; CALM1; FKBP1A; CACNA1A; HOMER3
GO:0021953	central nervous system neuron differentiation	3.06	2.26e-03	3.32e-02	9/54	DRAXIN; LMO4; NRP2; MAP2; MDGA1; HSP90AB1; FZD1; MYCBP2; CBLN1
GO:0097485	neuron projection guidance	2.93	1.42e-04	5.20e-03	15/94	DRAXIN; LHX9; NRXN1; NRP2; KLF7; ALCAM; SPON2; PDLIM7; TUBB2B; EZR; DPYSL2; FEZ1; MYCBP2; EFNB3; BSG
GO:0007517	muscle organ development	2.89	6.10e-05	2.98e-03	17/108	SEPN1; CENPF; RYR2; ZBTB18; SOX11; CHRNA1; DNER; GPX1; MEF2C; SRI; FZD1; G6PD; CHD7; MYL6; ACTC1; TCF12; FKBP1A
GO:0061564	axon development	2.84	4.68e-08	1.14e-05	32/207	DRAXIN; STMN1; PTPRF; S100A6; CRABP2; LHX9; NRXN1; NRP2; KLF7; MAP2; ALCAM; SPON2; PDLIM7; TUBB2B; HSP90AB1; DYNLT1; EZR; AUTS2; NEFM; NEFL; DPYSL2; ILK; FEZ1; ANK3; MYCBP2; EFNB3; RND2; NGFR; BAIAP2; BSG; RAB3A; RTN4R
GO:0031345	negative regulation of cell projection organization	2.78	2.74e-03	3.79e-02	10/66	DRAXIN; MAP2; ITM2C; PTPRG; NR2F1; DPYSL3; HDAC2; EFNB3; NGFR; RTN4R
GO:0010975	regulation of neuron projection development	2.74	2.83e-07	4.16e-05	30/201	ACAP3; DRAXIN; PTPRF; CRABP2; AGT; MAP2; ITM2C; PTPRG; TNIK; MEF2C; NR2F1; DPYSL3; TUBB2B; HDAC2; DYNLT1; CAMK2B; FZD1; NEFL; DPYSL2; RAPGEF1; ILK; CFL1; MYCBP2; SERPINF1; EFNB3; RND2; NGFR; BAIAP2; PREX1; RTN4R
GO:0060537	muscle tissue development	2.74	1.22e-04	4.72e-03	17/114	SEPN1; CENPF; AGT; RYR2; ZBTB18; SOX11; ID2; CHRNA1; IGFBP5; DNER; GPX1; MEF2C; G6PD; CHD7; MYL6; ACTC1; FKBP1A
GO:0050803	regulation of synapse structure or activity	2.72	1.30e-03	2.72e-02	12/81	NRXN1; NRP2; SNCA; GPM6A; MEF2C; TUBB; MDGA1; CAMK2B; FZD1; CFL1; CBLN1; BAIAP2
GO:0060560	developmental growth involved in morphogenesis	2.68	9.41e-04	2.16e-02	13/89	PRKCZ; DRAXIN; CRABP2; NRP2; MAP2; ALCAM; HSP90AB1; AUTS2; DPYSL2; ILK; GAL; RND2; RTN4R
GO:0072593	reactive oxygen species metabolic process	2.56	2.20e-03	3.29e-02	12/86	PRDX1; GADD45A; NOS1AP; AGT; GPX1; GNAI2; SNCA; HSP90AB1; G6PD; GSTP1; SH3PXD2A; PREX1
GO:0010721	negative regulation of cell development	2.53	4.82e-04	1.31e-02	16/116	DRAXIN; PBX1; SOX11; ID2; MAP2; ITM2C; PTPRG; NR2F1; DPYSL3; HDAC2; DYNLT1; G6PD; GAL; EFNB3; NGFR; RTN4R
GO:0050808	synapse organization	2.51	1.06e-04	4.56e-03	20/146	PTPRF; NOS1AP; NRXN1; CHRNA1; NRP2; DNER; SNCA; GPM6A; MEF2C; TUBB; MDGA1; ACTB; CAMK2B; FZD1; NEFL; CFL1; ANK3; CBLN1; BAIAP2; RAB3A
GO:0003013	circulatory system process	2.51	1.74e-03	3.12e-02	13/95	NOS1AP; ATP1B1; AGT; RYR2; ID2; MYL1; GPX1; GNAI2; SRI; AKAP9; CHD7; CALM1; ACTC1
GO:0009914	hormone transport	2.50	2.68e-03	3.78e-02	12/88	AGT; SOX11; NEUROD1; KLF7; CAPN10; STX1A; SRI; CHD7; SYT7; GAL; CACNA1A; SELM
GO:0023061	signal release	2.42	1.21e-04	4.72e-03	21/159	WLS; SYT11; AGT; SOX11; NRXN1; NEUROD1; KLF7; CAPN10; SNCA; MEF2C; CPLX2; GRM4; STX1A; SRI; CHD7; SYT7; GAL; CALM1; CACNA1A; RAB3A; SELM
GO:0051961	negative regulation of nervous system development	2.40	1.82e-03	3.15e-02	14/107	DRAXIN; PBX1; SOX11; ID2; MAP2; ITM2C; PTPRG; NR2F1; DPYSL3; HDAC2; DYNLT1; EFNB3; NGFR; RTN4R
GO:0051235	maintenance of location	2.38	1.99e-03	3.24e-02	14/108	SEPN1; RYR2; SNCA; MDFI; EZR; SRI; AKAP9; TMSB4X; CHD7; ANK3; JPH4; CALM1; FKBP1A; FTL
GO:0035690	cellular response to drug	2.36	2.17e-03	3.29e-02	14/109	SEPN1; RYR2; GNAI2; MEF2C; NR3C1; HSP90AB1; HDAC2; ACTB; RPS3; RGS10; HNRNPA1; SERPINF1; BAIAP2; PPP1R14A
GO:0051098	regulation of binding	2.32	2.25e-04	7.50e-03	21/166	STMN1; PTPRF; SOX11; ID2; NEUROD1; MAP2; HMGB2; MEF2C; MDFI; HSP90AB1; HDAC2; ACTB; SRI; TMSB4X; CTHRC1; CALM1; CCPG1; EIF4A3; FKBP1A; AES; MFNG
GO:0070972	protein localization to endoplasmic reticulum	2.31	1.84e-03	3.15e-02	15/119	RYR2; RPS27A; RPL29; RPS3A; RPL37; RPS4X; RPL39; RPL7; RPL12; RPL27A; RPS3; RPLP0; RPLP1; RPS11; RPL28
GO:0050769	positive regulation of neurogenesis	2.31	2.45e-04	7.69e-03	21/167	CRABP2; AGT; SOX11; ID2; NEUROD1; MEF2C; DPYSL3; TUBB2B; HDAC2; DYNLT1; CAMK2B; FZD1; NEFL; RAPGEF1; ILK; TCF12; SERPINF1; RND2; NGFR; BAIAP2; PCP4
GO:0002791	regulation of peptide secretion	2.27	3.05e-03	4.07e-02	14/113	PRKCZ; WLS; SYT11; NEUROD1; KLF7; CAPN10; BTN2A2; EZR; STX1A; SRI; TMSB4X; CHD7; SYT7; CACNA1A
GO:0051346	negative regulation of hydrolase activity	2.23	1.42e-03	2.81e-02	17/140	PRKCZ; AGT; PPP1R1C; MAP2; GPX1; GNAI2; SNCA; PTTG1; PPP1R17; PCSK1N; SERPINF1; NGFR; PPP1R27; FKBP1A; CST3; PPP1R14A; CSTB
GO:0032970	regulation of actin filament-based process	2.11	3.38e-03	4.43e-02	16/139	STMN1; RHOC; NOS1AP; RYR2; CDC42EP3; MEF2C; EZR; SRI; AKAP9; TMSB4X; GPM6B; ILK; CFL1; RND2; BAIAP2; PREX1
GO:0009636	response to toxic substance	2.06	1.91e-03	3.18e-02	19/169	HPCA; PRDX1; EPHX1; SCN9A; CHRNA1; EEF1B2; GPX1; HDAC2; ACTB; G6PD; NEFL; GSTP1; RPS3; FAM213A; RGS10; HNRNPA1; CALM1; ACTC1; SNN

---

Factor 5 : 13 significant GO terms

GeneSet	description	enrichRatio	pValue	FDR	GeneRatio	geneSymbols
GO:1902600	proton transmembrane transport	3.33	1.51e-05	1.84e-03	16/77	ATP6V0B; COX5B; ATP5G3; COX7C; TMSB4X; ATP5B; SLC25A3; COX6A1; ATP5A1; ATP5E; ATP5O; MT-CO1; MT-CO2; MT-CO3; MT-ND4; MT-CYB
GO:0010257	NADH dehydrogenase complex assembly	3.20	2.61e-04	1.92e-02	12/60	NDUFS2; NDUFS6; NDUFB11; NDUFS8; NDUFC2; NDUFA12; NDUFB10; NDUFAB1; ATP5SL; MT-ND1; MT-ND2; MT-ND4
GO:0009141	nucleoside triphosphate metabolic process	2.97	2.82e-09	1.04e-06	35/189	ATPIF1; NDUFS2; PARP1; COX5B; ATP5G3; SDHA; NDUFS6; COX7C; PMPCB; TMSB4X; PGK1; NDUFS8; NDUFC2; SDHD; HSPA8; PGAM1; TPI1; ATP5B; NDUFA12; COX6A1; NDUFB10; UQCRC2; NDUFAB1; COQ9; NCOR1; ATP5A1; ATP5E; ATP5O; MT-ND1; MT-ND2; MT-CO1; MT-CO2; MT-CO3; MT-ND4; MT-CYB
GO:0009123	nucleoside monophosphate metabolic process	2.88	6.69e-09	1.64e-06	35/195	ATPIF1; NDUFS2; PARP1; COX5B; ATP5G3; SDHA; NDUFS6; COX7C; PMPCB; TMSB4X; PGK1; NDUFS8; NDUFC2; SDHD; HSPA8; PGAM1; TPI1; ATP5B; NDUFA12; COX6A1; NDUFB10; UQCRC2; NDUFAB1; COQ9; NCOR1; ATP5A1; ATP5E; ATP5O; MT-ND1; MT-ND2; MT-CO1; MT-CO2; MT-CO3; MT-ND4; MT-CYB
GO:0006091	generation of precursor metabolites and energy	2.84	8.99e-11	6.60e-08	44/248	HMGCL; MTFR1L; ATPIF1; NDUFS2; FH; COX5B; PDHB; ADH5; SDHA; NDUFS6; COX7C; PRELID1; TBRG4; PMPCB; PGK1; PTGES2; NDUFS8; NDUFC2; SDHD; PGAM1; TPI1; ATP5B; NDUFA12; COX6A1; HMGB1; SUCLA2; NDUFB10; TRAP1; UQCRC2; NDUFAB1; CIAPIN1; COQ9; NCOR1; ATP5A1; ATP5E; GLTSCR2; ATP5O; MT-ND1; MT-ND2; MT-CO1; MT-CO2; MT-CO3; MT-ND4; MT-CYB
GO:0033108	mitochondrial respiratory chain complex assembly	2.58	8.61e-04	4.86e-02	14/87	NDUFS2; NDUFS6; NDUFB11; NDUFS8; NDUFC2; NDUFA12; NDUFB10; NDUFAB1; UQCC1; ATP5SL; SAMM50; MT-ND1; MT-ND2; MT-ND4
GO:0006413	translational initiation	2.55	1.04e-05	1.52e-03	25/157	YTHDF2; RPL5; TPR; DDX1; RPL31; EIF4A2; EIF4E; RPL34; RPS3A; HSPB1; RPS4X; RPL10; COPS5; RPL7; EIF3E; CDC123; RPS24; RPLP0; RPS29; EIF3J; EIF4A1; RPL19; EIF3D; RPL3; ATF4
GO:0070646	protein modification by small protein removal	2.45	6.86e-05	6.30e-03	22/144	USP39; PSMD6; PSMD2; COPS4; PSMB1; ACTB; PSMC2; COPS5; PSMB7; PSMD13; UBC; PSMC6; PSMC1; PSMB6; COPS3; PSMD11; PSMB3; PSMD3; PSMA7; KEAP1; PSMD8; GLTSCR2
GO:0009259	ribonucleotide metabolic process	2.43	1.11e-07	2.03e-05	39/257	HMGCL; ATPIF1; NDUFS2; PARP1; COX5B; ATP5G3; PDHB; SDHA; NDUFS6; COX7C; PMPCB; TMSB4X; PGK1; NDUFS8; NDUFC2; SDHD; HSPA8; PGAM1; TPI1; ATP5B; NDUFA12; COX6A1; SUCLA2; NDUFB10; UQCRC2; NDUFAB1; COQ9; NCOR1; ACSF2; ATP5A1; ATP5E; ATP5O; MT-ND1; MT-ND2; MT-CO1; MT-CO2; MT-CO3; MT-ND4; MT-CYB
GO:0043687	post-translational protein modification	2.43	2.52e-05	2.64e-03	25/165	PSMD6; UBA3; PSMD2; COPS4; PSMB1; PSMC2; RAB2A; COPS5; DCAF13; PSMB7; PSMD13; PSMC6; KTN1; PSMC1; PSMB6; COPS3; PSMD11; PSMB3; PSMD3; PSMA7; FBXL12; KEAP1; RAB8A; PSMD8; FBXO7
GO:0006457	protein folding	2.21	8.28e-04	4.86e-02	19/138	SEP15; PFDN2; CCT7; DNAJB2; CCT5; TBCC; HSP90AB1; TCP1; HSPB1; PRDX4; VBP1; HSPA8; ERP29; PSMC1; HSP90AA1; TRAP1; EMC6; VAPA; FKBP1A
GO:0051098	regulation of binding	2.12	5.59e-04	3.73e-02	22/166	PEX14; PARP1; NEUROD1; DNAJB2; CRBN; HMGB2; PPP2CA; MDFI; HSP90AB1; ACTB; TMSB4X; EIF3E; HSF1; TDG; HMGB1; CALM1; WFIKKN1; TRAF4; EIF4A3; FKBP1A; EIF3D; MFNG
GO:0006401	RNA catabolic process	2.04	1.21e-04	9.86e-03	30/236	PPP1R8; YTHDF2; RPL5; RBM8A; RNASEH1; RPL31; PCBP4; RPL34; RPS3A; PPP2CA; HNRNPA0; TBRG4; HSPB1; RPS4X; RPL10; RPL7; EIF3E; ZPR1; HSPA8; RPS24; RPLP0; UBC; RPS29; SLIRP; RNPS1; RPL19; EIF4A3; HNRNPM; PPP2R1A; RPL3

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Factor 6 : 4 significant GO terms

GeneSet	description	enrichRatio	pValue	FDR	GeneRatio	geneSymbols
GO:0046683	response to organophosphorus	6.80	5.51e-05	0.0399	7/34	HSPD1; NDUFS4; EZR; HSPA5; LDHA; HSP90B1; NME1
GO:0014074	response to purine-containing compound	5.92	1.39e-04	0.0399	7/39	HSPD1; NDUFS4; EZR; HSPA5; LDHA; HSP90B1; NME1
GO:0006457	protein folding	3.11	2.42e-04	0.0443	13/138	PDIA6; FKBP1B; HSPD1; HSPE1; CANX; HSP90AB1; PRDX4; HSPA5; HSP90B1; HSP90AA1; PDIA3; PPIB; CALR
GO:0009141	nucleoside triphosphate metabolic process	2.79	1.63e-04	0.0399	16/189	ENO1; GUK1; COX5B; NDUFS4; UQCRB; AK1; LDHA; BAD; COX6A1; RAN; PKM; NME1; NDUFS7; UQCR10; ATP5O; MT-CYB

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Factor 7 : 21 significant GO terms

GeneSet	description	enrichRatio	pValue	FDR	GeneRatio	geneSymbols
GO:0070972	protein localization to endoplasmic reticulum	6.64	0.00e+00	0.00e+00	58/119	RPL11; RPS8; RPL5; RPS27; RTN4; RPS27A; RPL37A; RPL32; RPL15; RPSA; RPL29; SPCS1; RPL9; RPL34; RPS3A; RPL37; RPS23; RPS14; RPS18; RPL10A; RPS12; SEC61G; RPS4X; RPL39; RPL10; RPS20; RPL7; RPL30; RPS6; SEC61B; RPL35; RPL7A; RPL27A; RPS13; RPS3; RPS24; RPS26; RPL41; RPL6; RPLP0; RPL21; RPS29; SRP14; RPL4; RPS17; RPS2; RPS15A; RPL13; RPL26; RPL23A; RPL23; RPL19; RPL18A; RPS19; RPL18; RPL13A; RPS11; RPL3
GO:0010257	NADH dehydrogenase complex assembly	6.36	0.00e+00	0.00e+00	28/60	NDUFS5; NDUFB3; NDUFAF3; NDUFB4; NDUFC1; NDUFS6; NDUFA2; NDUFB2; NDUFB11; NDUFA1; NDUFB9; TMEM261; NDUFB6; NDUFS8; NDUFC2; NDUFB8; NDUFB1; NDUFB10; NDUFAB1; NDUFS7; NDUFA11; NDUFA7; NDUFB7; NDUFA13; NDUFA3; NDUFA6; MT-ND3; MT-ND4
GO:0033108	mitochondrial respiratory chain complex assembly	5.79	0.00e+00	0.00e+00	37/87	NDUFS5; COX20; NDUFB3; NDUFAF3; COX17; NDUFB4; NDUFC1; NDUFS6; NDUFA2; UQCC2; NDUFB2; NDUFB11; NDUFA1; UQCRB; NDUFB9; TMEM261; NDUFB6; NDUFS8; NDUFC2; NDUFB8; COX14; COX16; NDUFB1; NDUFB10; NDUFAB1; COA3; NDUFS7; NDUFA11; PET100; NDUFA7; NDUFB7; NDUFA13; NDUFA3; UQCR10; NDUFA6; MT-ND3; MT-ND4
GO:1902600	proton transmembrane transport	5.66	0.00e+00	0.00e+00	32/77	PARK7; ATP6V0B; COX5B; ATP5G3; COX17; ATP5I; COX7C; COX7A2; NDUFA4; ATP5J2; ATP6V1F; TMSB4X; COX7B; COX6C; ATP6V1G1; COX8A; ATP5L; ATP5G2; SLC25A3; COX6A1; COX5A; COX4I1; ATP5G1; ATP5H; ATP5A1; ATP5E; NDUFS7; COX6B1; ATP5J; ATP5O; MT-CO1; MT-ND4
GO:0006413	translational initiation	5.64	0.00e+00	0.00e+00	65/157	RPL11; RPS8; RPL5; RPS27; DDX1; RPS27A; RPL37A; RPL32; RPL15; RPSA; RPL29; EIF4A2; RPL9; RPL34; RPS3A; RPL37; RPS23; RPS14; RPS18; RPL10A; RPS12; RPS4X; RPL39; MCTS1; RPL10; EIF4EBP1; RPS20; RPL7; RPL30; EIF3E; EIF3H; RPS6; RPL35; RPL7A; EIF3F; RPL27A; RPS13; RPS3; RPS24; RPS26; RPL41; RPL6; RPLP0; RPL21; RPS29; EIF3J; RPL4; RPS17; RPS2; RPS15A; RPL13; RPL26; RPL23A; RPL23; RPL19; EIF1; RPL18A; EIF3K; RPS19; RPL18; RPL13A; RPS11; EIF3L; RPL3; ATF4
GO:0002181	cytoplasmic translation	5.41	4.22e-15	2.38e-13	29/73	RPL11; RPL32; RPL15; TMA7; RPL29; RPL9; RPS23; RPL10A; RPL39; MCTS1; EIF4EBP1; RPL30; EIF3E; EIF3H; EIF3F; RPS26; RPL41; RPL6; RPLP0; RPS29; EIF3J; RPL26; RPL19; EEF2; RPL18A; EIF3K; RPL18; RPL13A; EIF3L
GO:0090150	establishment of protein localization to membrane	4.54	0.00e+00	0.00e+00	68/204	RPL11; RPS8; RPL5; RPS27; RPS27A; RPL37A; RPL32; RPL15; RPSA; RPL29; RPL9; RPL34; RPS3A; RPL37; RPS23; RPS14; GNB2L1; RPS18; RPL10A; CD24; RPS12; FIS1; RPS4X; RPL39; RPL10; RPS20; RPL7; RPL30; YWHAZ; RPS6; SEC61B; RPL35; RPL7A; RPL27A; RPS13; TIMM10; RPS3; RPS24; RPS26; RPL41; RPL6; RPLP0; RPL21; RPS29; CALM1; HSP90AA1; SRP14; RPL4; RPS17; RPS2; RPS15A; RPL13; YWHAE; VAMP2; RPL26; RPL23A; RPL23; RPL19; ROMO1; TIMM13; RPL18A; NDUFA13; PDCD5; RPS19; RPL18; RPL13A; RPS11; RPL3
GO:0017004	cytochrome complex assembly	4.38	1.10e-04	4.05e-03	9/28	COX20; COX17; UQCC2; UQCRB; COX14; COX16; COA3; PET100; UQCR10
GO:0099132	ATP hydrolysis coupled cation transmembrane transport	4.26	5.98e-05	2.44e-03	10/32	ATP6V0B; ATP5G3; ATP6V1F; ATP5L; ATP5G2; ATP5G1; ATP5H; ATP5A1; ATP5E; ATP5O
GO:0009141	nucleoside triphosphate metabolic process	4.11	0.00e+00	0.00e+00	57/189	PARK7; ATPIF1; NDUFS5; UQCRH; COX5B; ATP5G3; NDUFB3; NDUFB4; ATP5I; NDUFC1; NDUFS6; COX7C; UQCRQ; NDUFA2; UQCC2; COX7A2; NDUFA4; CYCS; ATP5J2; NDUFB2; TMSB4X; NDUFA1; UQCRB; NDUFB9; NDUFB6; AK1; NDUFS8; NDUFC2; ATP5L; NDUFB8; TPI1; ATP5G2; COX6A1; RAN; DNAJC15; NDUFB1; COX5A; NDUFB10; NDUFAB1; DCTPP1; COX4I1; ATP5G1; NME1; ATP5H; ATP5A1; ATP5E; NDUFS7; NDUFA7; NDUFB7; NDUFA3; UQCR10; NDUFA6; ATP5J; ATP5O; MT-CO1; MT-ND3; MT-ND4
GO:0001906	cell killing	3.89	6.57e-04	2.30e-02	8/28	HMGN2; PRDX1; TUBB; RPL30; CADM1; VAMP2; ROMO1; RPS19
GO:0009123	nucleoside monophosphate metabolic process	3.84	0.00e+00	0.00e+00	55/195	PARK7; ATPIF1; NDUFS5; UQCRH; COX5B; ATP5G3; NDUFB3; NDUFB4; ATP5I; NDUFC1; NDUFS6; COX7C; UQCRQ; NDUFA2; UQCC2; COX7A2; HDDC2; NDUFA4; CYCS; ATP5J2; NDUFB2; TMSB4X; NDUFA1; UQCRB; NDUFB9; NDUFB6; AK1; NDUFS8; NDUFC2; ATP5L; NDUFB8; TPI1; ATP5G2; COX6A1; DNAJC15; NDUFB1; COX5A; NDUFB10; NDUFAB1; COX4I1; ATP5G1; ATP5H; ATP5A1; ATP5E; NDUFS7; NDUFA7; NDUFB7; NDUFA3; UQCR10; NDUFA6; ATP5J; ATP5O; MT-CO1; MT-ND3; MT-ND4
GO:0006605	protein targeting	3.81	0.00e+00	0.00e+00	73/261	RPL11; ATPIF1; RPS8; RPL5; RPS27; RPS27A; RPL37A; RPL32; RPL15; RPSA; RPL29; SPCS1; RPL9; RPL34; RPS3A; RPL37; RPS23; RPS14; RPS18; RPL10A; RPS12; TOMM7; SEC61G; FIS1; SLC25A6; RPS4X; RPL39; RPL10; RPS20; RPL7; RPL30; YWHAZ; RPS6; SEC61B; RPL35; RPL7A; RPL27A; RPS13; IMMP1L; TIMM10; RPS3; TIMM8B; RPS24; RPS26; RPL41; RPL6; RPLP0; UBC; RPL21; DNAJC15; RPS29; HSP90AA1; SRP14; RPL4; RPS17; RPS2; RPS15A; RPL13; RPL26; RPL23A; RPL23; RPL19; ROMO1; TIMM13; UBL5; RPL18A; NDUFA13; PDCD5; RPS19; RPL18; RPL13A; RPS11; RPL3
GO:0006401	RNA catabolic process	3.69	0.00e+00	0.00e+00	64/236	RPL11; RPS8; RPL5; RPS27; RPS27A; RPL37A; RPL32; LSM3; RPL15; RPSA; RPL29; RPL9; RPL34; LSM6; RPS3A; RPL37; RPS23; RPS14; RPS18; RPL10A; RPS12; LSM5; LINC01420; RPS4X; RPL39; RPL10; RPS20; RPL7; RPL30; YWHAZ; EIF3E; RPS6; RPL35; RPL7A; RPL27A; RPS13; RNASEH2C; RPS3; RPS24; RPS26; RPL41; RPL6; RPLP0; UBC; RPL21; RPS29; SLIRP; RPL4; RPS17; RPS2; RPS15A; RPL13; RPL26; RPL23A; RPL23; RPL19; LSM7; RPL18A; LSM4; RPS19; RPL18; RPL13A; RPS11; RPL3
GO:0007006	mitochondrial membrane organization	3.49	1.28e-07	6.69e-06	22/86	ATPIF1; ATP5G3; ATP5I; DYNLT1; ATP5J2; YWHAZ; TIMM10; ATP5L; ATP5G2; CALM1; HSP90AA1; YWHAE; ATP5G1; ATP5H; ATP5A1; ROMO1; ATP5E; TIMM13; NDUFA13; PDCD5; ATP5J; ATP5O
GO:0006091	generation of precursor metabolites and energy	3.41	0.00e+00	0.00e+00	62/248	PARK7; SH3BGRL3; ATPIF1; NDUFS5; UQCRH; COX20; COX5B; NDUFB3; COX17; NDUFB4; ATP5I; NDUFC1; NDUFS6; COX7C; GLRX; UQCRQ; NDUFA2; UQCC2; COX7A2; NDUFA4; CYCS; ATP5J2; NDUFB2; COX7B; NDUFA1; UQCRB; COX6C; NDUFB9; NDUFB6; COX8A; NDUFS8; NDUFC2; ATP5L; CISD1; NDUFB8; TPI1; BLOC1S1; COX6A1; HMGB1; DNAJC15; NDUFB1; COX5A; NDUFB10; NDUFAB1; COX4I1; ATP5H; ATP5A1; ATP5E; NDUFS7; UQCR11; NDUFA7; NDUFB7; COX6B1; ETFB; NDUFA3; UQCR10; NDUFA6; ATP5J; ATP5O; MT-CO1; MT-ND3; MT-ND4
GO:0009259	ribonucleotide metabolic process	3.07	1.11e-15	6.79e-14	58/257	PARK7; ATPIF1; NDUFS5; UQCRH; COX5B; DBI; ATP5G3; NDUFB3; NDUFB4; ATP5I; NDUFC1; NDUFS6; COX7C; HINT1; UQCRQ; NDUFA2; UQCC2; COX7A2; NDUFA4; CYCS; ATP5J2; NDUFB2; TMSB4X; NDUFA1; UQCRB; NDUFB9; NDUFB6; AK1; NDUFS8; NDUFC2; ATP5L; NDUFB8; TPI1; ATP5G2; COX6A1; RAN; DNAJC15; NDUFB1; COX5A; NDUFB10; NDUFAB1; COX4I1; ATP5G1; NME1; ATP5H; ATP5A1; ATP5E; NDUFS7; NDUFA7; NDUFB7; NDUFA3; UQCR10; NDUFA6; ATP5J; ATP5O; MT-CO1; MT-ND3; MT-ND4
GO:0070585	protein localization to mitochondrion	2.64	1.10e-04	4.05e-03	18/93	ATPIF1; TOMM7; FIS1; SLC25A6; YWHAZ; IMMP1L; TIMM10; TIMM8B; DDIT3; DNAJC15; CALM1; HSP90AA1; YWHAE; ROMO1; TIMM13; UBL5; NDUFA13; PDCD5
GO:0006839	mitochondrial transport	2.50	6.01e-06	2.60e-04	27/147	ATPIF1; COX5B; ATP5I; DYNLT1; TOMM7; ATP5J2; FIS1; SLC25A6; YWHAZ; IMMP1L; TIMM10; TIMM8B; ATP5L; DNAJC15; HSP90AA1; YWHAE; ATP5H; ATP5A1; ROMO1; ATP5E; TIMM13; UBL5; NDUFA13; PDCD5; SMDT1; ATP5J; ATP5O
GO:0071826	ribonucleoprotein complex subunit organization	2.36	3.14e-06	1.44e-04	32/185	MRPL20; RPL11; RPL5; RPS27; SNRPE; DDX1; SNRPG; LSM3; RPSA; RPS23; RPS14; LINC01420; MCTS1; RPL10; EIF3E; EIF3H; EIF3F; SNRPF; RPL6; RPLP0; HSP90AA1; EIF3J; RPL23A; SNRPD1; LSM4; EIF3K; RPS19; SNRPD2; RPL13A; EIF3L; RPL3; SNU13
GO:0022613	ribonucleoprotein complex biogenesis	2.02	8.46e-07	4.14e-05	49/330	MRPL20; RPL11; RPS8; RPL5; RPS27; SNRPE; DDX1; SNRPG; LSM3; RPSA; LSM6; RPS23; RPS14; NHP2; RPL10A; GTF2H5; LINC01420; MCTS1; RPL10; RPL7; EIF3E; EIF3H; RPS6; RPL35; RPL7A; EIF3F; TRMT112; RPS24; PA2G4; SNRPF; RPL6; RPLP0; RAN; HSP90AA1; NOP10; EIF3J; RPS17; RPS2; RPL26; RPL23A; SNRPD1; LSM4; EIF3K; RPS19; SNRPD2; RPL13A; EIF3L; RPL3; SNU13

---

Factor 8 : 7 significant GO terms

GeneSet	description	enrichRatio	pValue	FDR	GeneRatio	geneSymbols
GO:0050954	sensory perception of mechanical stimulus	4.42	3.33e-04	3.49e-02	8/39	CASP3; FAM65B; POU3F4; NAV2; COL2A1; CACNB3; SRRM4; SIX1
GO:0070972	protein localization to endoplasmic reticulum	4.17	2.92e-09	2.14e-06	23/119	RPL32; RPL24; RPL34; RPS18; RPL36A; RPL10; RPL8; RPL12; RPL27A; RPS13; RPS3; RPS26; RPL41; OS9; RPL6; RPLP0; RPS17; RPL13; RPL26; RPL23A; RPL23; RPL36; RPL28
GO:0002181	cytoplasmic translation	3.55	1.10e-04	1.61e-02	12/73	RPL32; RPL24; RPL36A; RPL8; ZNF385A; RPS26; RPL41; RPL6; RPLP0; DENR; RPL26; RPL36
GO:0006413	translational initiation	3.16	6.32e-07	1.55e-04	23/157	RPL32; RPL24; RPL34; RPS18; RPL36A; RPL10; RPL8; RPL12; RPL27A; RPS13; RPS3; RPS26; RPL41; RPL6; RPLP0; DENR; RPS17; RPL13; RPL26; RPL23A; RPL23; RPL36; RPL28
GO:0090150	establishment of protein localization to membrane	2.85	5.20e-07	1.55e-04	27/204	RPL32; RPL24; NSG1; RPL34; GNB2L1; RPS18; RPL36A; RPL10; RPL8; RPL12; RPL27A; RPS13; RPS3; CACNB3; RPS26; RPL41; RPL6; RPLP0; CALM1; RPS17; RPL13; VAMP2; RPL26; RPL23A; RPL23; RPL36; RPL28
GO:0006401	RNA catabolic process	2.47	9.11e-06	1.67e-03	27/236	RPL32; RPL24; RPL34; RPS18; LIN28B; RPL36A; RPL10; RPL8; RPL12; RPL27A; RPS13; RNASEH2C; RPS3; MAGOHB; PYM1; RPS26; RPL41; CNOT2; RPL6; RPLP0; RPS17; RPL13; RPL26; RPL23A; RPL23; RPL36; RPL28
GO:0006605	protein targeting	2.15	1.48e-04	1.81e-02	26/261	RPL32; RPL24; RPL34; RPS18; TOMM7; SLC25A6; RPL36A; RPL10; RPL8; RPL12; RPL27A; RPS13; RPS3; CACNB3; RPS26; RPL41; OS9; RPL6; RPLP0; RPS17; RPL13; RPL26; RPL23A; RPL23; RPL36; RPL28

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Factor 9 : 72 significant GO terms

GeneSet	description	enrichRatio	pValue	FDR	GeneRatio	geneSymbols
GO:0048645	animal organ formation	9.85	7.37e-05	0.00492	5/11	GNG5; CTNNB1; ROBO1; MEF2C; SIX1
GO:0007218	neuropeptide signaling pathway	8.67	7.45e-04	0.01709	4/10	GAL; NMB; SSTR2; PTH2
GO:0034109	homotypic cell-cell adhesion	7.22	1.05e-04	0.00552	6/18	CLIC1; ACTB; ILK; ANK3; VCL; ACTG1
GO:0007586	digestion	6.67	2.27e-03	0.02979	4/13	NEUROD1; SST; NEUROG1; LIMA1
GO:0048483	autonomic nervous system development	6.67	2.27e-03	0.02979	4/13	CTNNB1; SIX1; INSM1; ADARB1
GO:0021675	nerve development	4.92	2.77e-03	0.03444	5/22	CTNNB1; NEUROG1; ILK; SIX1; ADARB1
GO:0030048	actin filament-based movement	4.64	9.52e-05	0.00552	9/42	ANK2; CAMK2D; CACNA2D1; TPM2; MYL6; ACTC1; EMP2; TNNC2; TPM4
GO:0010927	cellular component assembly involved in morphogenesis	4.60	6.21e-04	0.01519	7/33	WDR1; ANK2; MEF2C; ILK; ACTC1; ACTG1; EPB41L3
GO:0035249	synaptic transmission, glutamatergic	4.51	4.14e-03	0.04473	5/24	NRXN1; GRIA2; MEF2C; SLC17A6; SYT1
GO:0001763	morphogenesis of a branching structure	4.33	9.03e-04	0.01842	7/35	PBX1; CTNNB1; TNC; ILK; SIX1; PGF; PKD1
GO:0045165	cell fate commitment	4.15	2.38e-04	0.00864	9/47	ID2; NEUROD1; CTNNB1; CASP3; MEF2C; NEUROG1; EBF2; SIX1; ONECUT2
GO:0003007	heart morphogenesis	4.06	2.72e-05	0.00249	12/64	JUN; GNG5; ID2; CTNNB1; ROBO1; IFT57; COL4A3BP; MEF2C; OLFM1; ILK; SIX1; ACTC1
GO:0035270	endocrine system development	4.06	2.99e-03	0.03565	6/32	PBX1; NEUROD1; CDKN1C; SIX1; ONECUT2; INSM1
GO:0031032	actomyosin structure organization	4.04	6.25e-05	0.00492	11/59	STMN1; EPB41; RHOC; CD47; WDR1; MEF2C; ZYX; ACTC1; PFN1; ACTG1; EPB41L3
GO:0060560	developmental growth involved in morphogenesis	3.89	2.18e-06	0.00069	16/89	DRAXIN; CRABP2; ZEB2; MAP2; CTNNB1; ALCAM; MAP1B; TNC; OLFM1; ILK; GAL; VCL; SYT1; SIX1; SYT4; DCC
GO:0007272	ensheathment of neurons	3.89	1.77e-03	0.02699	7/39	POU3F1; CNTN2; CTNNB1; ANK2; ILK; EPB41L3; LGI4
GO:0030534	adult behavior	3.85	8.92e-04	0.01842	8/45	CNTN2; ID2; NRXN1; HDAC2; PBX3; PCDH17; LGI4; SEZ6L
GO:0098742	cell-cell adhesion via plasma-membrane adhesion molecules	3.79	2.06e-03	0.02838	7/40	CNTN2; NRXN1; ROBO1; ALCAM; CADM1; PCDH17; PKD1
GO:1904029	regulation of cyclin-dependent protein kinase activity	3.79	2.06e-03	0.02838	7/40	GADD45A; CCNI; CASP3; ACTB; CDKN1C; CCNY; PKD1
GO:0003012	muscle system process	3.68	5.99e-07	0.00044	19/112	CHRNA1; ANK2; CAMK2D; SORBS2; COL4A3BP; MEF2C; NEUROG1; HDAC2; CACNA2D1; TPM2; VCL; MYL6; AKAP6; CALM1; ACTC1; SSTR2; TNNC2; TPM4; FXYD1
GO:0008544	epidermis development	3.61	1.80e-04	0.00817	11/66	POU3F1; CRABP2; PKP4; SATB1; CTNNB1; CASP3; FAM65B; HDAC2; AGPAT2; GAL; TNFRSF19
GO:0021953	central nervous system neuron differentiation	3.61	7.00e-04	0.01658	9/54	DRAXIN; CNTN2; ZEB2; MAP2; CTNNB1; ROBO1; POU3F4; DCC; ADARB1
GO:0090130	tissue migration	3.57	1.38e-05	0.00145	15/91	JUN; ZEB2; SCG2; IQSEC1; ROBO1; MEF2C; SPARC; MEOX2; TMSB4X; CORO1C; ACTC1; EMP2; SERPINF1; PFN1; MAPRE2
GO:0001655	urogenital system development	3.56	1.05e-04	0.00552	12/73	PBX1; ID2; CTNNB1; MEF2C; TNC; CDKN1C; ILK; EMX2; SIX1; PGF; PKD1; SERPINF1
GO:0035637	multicellular organismal signaling	3.53	3.16e-03	0.03683	7/43	CHRNA1; ANK2; CAMK2D; CACNA2D1; ANK3; ATP2B1; CALM1
GO:0048568	embryonic organ development	3.51	4.68e-06	0.00081	17/105	MFAP2; NES; PBX1; VASH2; ID2; NCOA1; NEUROD1; CTNNB1; IFT57; MEF2C; NEUROG1; FAM65B; POU3F4; CTHRC1; CDKN1C; SIX1; PKD1
GO:0032409	regulation of transporter activity	3.48	7.01e-05	0.00492	13/81	ANK2; CAMK2D; MEF2C; GLRX; ACTB; CACNA2D1; TMSB4X; GAL; FXYD6; ANK3; AKAP6; CALM1; FXYD1
GO:0043588	skin development	3.42	1.05e-03	0.02028	9/57	STMN1; POU3F1; PKP4; CTNNB1; CASP3; HDAC2; GAL; TNFRSF19; PKD1
GO:0009612	response to mechanical stimulus	3.40	2.08e-03	0.02838	8/51	JUN; GADD45A; NRXN1; NEUROG1; FAM65B; ETV1; TNC; PKD1
GO:0015850	organic hydroxy compound transport	3.40	2.08e-03	0.02838	8/51	NCOA1; ACTB; SYT7; GAL; LIMA1; SYT1; SYT4; SELM
GO:0070661	leukocyte proliferation	3.33	2.36e-03	0.03035	8/52	SATB1; CTNNB1; CASP3; MEF2C; BTN2A2; GAL; RPS3; CADM1
GO:0061351	neural precursor cell proliferation	3.27	2.67e-03	0.03376	8/53	GNG5; NES; ID2; ZEB2; CTNNB1; ILK; EMX2; INSM1
GO:0043270	positive regulation of ion transport	3.19	9.90e-04	0.01964	10/68	ANK2; GLRX; CACNA2D1; TMSB4X; GAL; ANK3; AKAP6; CALM1; SYT4; FXYD1
GO:0006814	sodium ion transport	3.15	3.39e-03	0.03883	8/55	CAMK2D; GLRX; SLC17A6; FXYD6; ANK3; ASIC1; NKAIN4; FXYD1
GO:0097305	response to alcohol	3.10	1.25e-03	0.02217	10/70	EEF1B2; CTNNB1; SPARC; HDAC2; LANCL2; TNC; ATP2B1; CALM1; ACTC1; MT-ND4
GO:0007015	actin filament organization	3.07	5.52e-06	0.00081	20/141	STMN1; RHOC; ARPC5; CDC42EP3; RND3; CD47; WDR1; SORBS2; DPYSL3; CAP2; ZYX; TMSB4X; TPM2; CFL1; LIMA1; ACTC1; EMP2; PFN1; PREX1; TPM4
GO:0060485	mesenchyme development	3.05	1.39e-03	0.02271	10/71	ZEB2; CTNNB1; ROBO1; MEF2C; HDAC2; OLFM1; CFL1; CORO1C; SIX1; ACTC1
GO:0050673	epithelial cell proliferation	3.00	3.29e-04	0.01051	13/94	JUN; VASH2; ID2; SCG2; CTNNB1; ROBO1; IFT57; MEF2C; SPARC; CDKN1C; SIX1; PGF; SERPINF1
GO:0090596	sensory organ morphogenesis	2.99	4.73e-03	0.04825	8/58	MFAP2; CTNNB1; NEUROG1; FAM65B; HDAC2; POU3F4; CTHRC1; SIX1
GO:0099504	synaptic vesicle cycle	2.99	5.72e-04	0.01493	12/87	NRXN1; CTNNB1; DNM1; SLC17A6; SYT7; SYT1; PCDH17; TRIM9; CALM1; DOC2B; ACTG1; SYT4
GO:0034330	cell junction organization	2.97	2.11e-04	0.00817	14/102	RHOC; PKP4; IQSEC1; CTNNB1; WDR1; ANK2; ACTB; ILK; CADM1; VCL; CORO1C; ACTG1; EPB41L3; MAPRE2
GO:0034764	positive regulation of transmembrane transport	2.95	3.01e-03	0.03565	9/66	ANK2; GLRX; CACNA2D1; TMSB4X; GAL; ANK3; AKAP6; CALM1; FXYD1
GO:0071241	cellular response to inorganic substance	2.95	3.01e-03	0.03565	9/66	JUN; ID2; CAMK2D; MEF2C; SYT7; ANK3; SYT1; SERPINF1; SYT4
GO:0031589	cell-substrate adhesion	2.87	1.35e-03	0.02271	11/83	CTNNB1; ZYX; NINJ1; ILK; RSU1; VCL; CORO1C; PKD1; EMP2; ONECUT2; PREX1
GO:0001667	ameboidal-type cell migration	2.86	1.17e-04	0.00574	16/121	JUN; ZEB2; SCG2; IQSEC1; ROBO1; MEF2C; SPARC; MEOX2; TMSB4X; ILK; CFL1; CORO1C; EMP2; SERPINF1; PFN1; MAPRE2
GO:0010959	regulation of metal ion transport	2.84	5.51e-04	0.01493	13/99	CTNNB1; ANK2; CAMK2D; GLRX; CACNA2D1; GAL; FXYD6; ANK3; AKAP6; CALM1; NKAIN4; HOMER3; FXYD1
GO:0022604	regulation of cell morphogenesis	2.83	2.82e-06	0.00069	24/184	DRAXIN; EPB41; RHOC; S100A13; CRABP2; CNTN2; CDC42EP3; ZEB2; RND3; MAP2; ROBO1; WDR1; MAP1B; SPARC; OLFM1; ILK; CFL1; SYT1; CORO1C; LINGO1; EPB41L3; SYT4; DCC; PREX1
GO:0010721	negative regulation of cell development	2.80	2.47e-04	0.00864	15/116	DRAXIN; PBX1; CNTN2; ID2; MAP2; ITM2C; CTNNB1; NR2F1; DPYSL3; HDAC2; GAL; CORO1C; LINGO1; SYT4; DCC
GO:0001525	angiogenesis	2.76	4.69e-04	0.01378	14/110	JUN; SHC1; VASH2; SCG2; CTNNB1; ROBO1; SPARC; THSD7A; MEOX2; SAT1; VAV2; PGF; EMP2; SERPINF1
GO:0048638	regulation of developmental growth	2.71	8.88e-04	0.01842	13/104	DRAXIN; CRABP2; MAP2; MAP1B; MEF2C; OLFM1; ILK; GAL; SYT1; AKAP6; SIX1; SYT4; DCC
GO:0048880	sensory system development	2.65	1.67e-03	0.02610	12/98	MFAP2; JUN; NES; ZEB2; NEUROD1; CTNNB1; HDAC2; NINJ1; CDKN1C; ATP2B1; MAB21L1; SERPINF1
GO:0051961	negative regulation of nervous system development	2.63	1.16e-03	0.02133	13/107	DRAXIN; PBX1; CNTN2; ID2; MAP2; ITM2C; CTNNB1; NR2F1; DPYSL3; HDAC2; LINGO1; SYT4; DCC
GO:0061564	axon development	2.62	7.11e-06	0.00087	25/207	DRAXIN; STMN1; JUN; SHC1; CRABP2; LHX9; CNTN2; NRXN1; ZEB2; MAP2; ROBO1; ALCAM; CASP3; MAP1B; PDLIM7; ETV1; TNC; OLFM1; ILK; NCAM1; ANK3; VCL; LINGO1; DCC; ADARB1
GO:0007517	muscle organ development	2.61	1.27e-03	0.02217	13/108	CHRNA1; CTNNB1; MEF2C; NEUROG1; FAM65B; ETV1; MEOX2; MYL6; AKAP6; SIX1; ACTC1; TCF12; ADARB1
GO:0007163	establishment or maintenance of cell polarity	2.60	1.99e-03	0.02838	12/100	RHOC; ARPC5; RND3; MAP2; FRMD4B; WDR1; MAP1B; CAP2; FAM65B; ILK; CFL1; PKD1
GO:0034765	regulation of ion transmembrane transport	2.59	8.81e-04	0.01842	14/117	WDR1; ANK2; CAMK2D; MEF2C; GLRX; CLIC1; CACNA2D1; TMSB4X; GAL; FXYD6; ANK3; AKAP6; CALM1; FXYD1
GO:0002009	morphogenesis of an epithelium	2.55	4.61e-04	0.01378	16/136	RHOC; PBX1; ZEB2; CTNNB1; IFT57; WDR1; MEF2C; CTHRC1; TNC; ILK; CFL1; VCL; SIX1; PGF; PKD1; PFN1
GO:0097485	neuron projection guidance	2.54	3.71e-03	0.04125	11/94	DRAXIN; SHC1; LHX9; CNTN2; NRXN1; ROBO1; ALCAM; PDLIM7; ETV1; NCAM1; DCC
GO:0042391	regulation of membrane potential	2.53	1.13e-03	0.02133	14/120	JUN; NRXN1; CHRNA1; WDR1; ANK2; CAMK2D; MEF2C; GLRX; CLIC1; CACNA2D1; ANK3; ASIC1; AKAP6; FXYD1
GO:0001503	ossification	2.51	4.03e-03	0.04413	11/95	PBX1; ID2; CTNNB1; MEF2C; SPARC; PDLIM7; CLIC1; CTHRC1; TNC; ILK; TPM4
GO:0032970	regulation of actin filament-based process	2.49	5.90e-04	0.01493	16/139	STMN1; RHOC; ARPC5; CDC42EP3; RND3; CD47; WDR1; ANK2; CAMK2D; MEF2C; TMSB4X; ILK; CFL1; LIMA1; PFN1; PREX1
GO:0051271	negative regulation of cellular component movement	2.48	4.37e-03	0.04648	11/96	SRGAP3; ROBO1; MEF2C; DPYSL3; FAM65B; MEOX2; ILK; VCL; CORO1C; SERPINF1; ADARB1
GO:0051098	regulation of binding	2.48	1.95e-04	0.00817	19/166	STMN1; EPB41; JUN; NES; ID2; NEUROD1; MAP2; CTNNB1; MEF2C; FAM65B; HDAC2; ACTB; TMSB4X; EBF2; CTHRC1; CALM1; CCPG1; WFIKKN1; PKD1
GO:0010038	response to metal ion	2.47	2.09e-03	0.02838	13/114	JUN; S100A13; ID2; CAMK2D; CASP3; MEF2C; SPARC; SYT7; ANK3; SYT1; CALM1; SERPINF1; SYT4
GO:0050769	positive regulation of neurogenesis	2.46	2.11e-04	0.00817	19/167	CRABP2; ID2; NCOA1; ZEB2; NEUROD1; CTNNB1; ROBO1; MAP1B; MEF2C; NEUROG1; DPYSL3; HDAC2; ILK; SYT1; TCF12; SERPINF1; SYT4; TCF4; PCP4
GO:0007389	pattern specification process	2.36	4.44e-03	0.04655	12/110	PBX1; ZEB2; NEUROD1; CTNNB1; ROBO1; IFT57; MEF2C; NEUROG1; MEOX2; PBX3; EMX2; SIX1
GO:0010975	regulation of neuron projection development	2.26	3.26e-04	0.01051	21/201	DRAXIN; CRABP2; CNTN2; ZEB2; MAP2; ITM2C; ROBO1; MAP1B; MEF2C; NR2F1; DPYSL3; HDAC2; OLFM1; ILK; CFL1; SYT1; LINGO1; SERPINF1; SYT4; DCC; PREX1
GO:0030900	forebrain development	2.25	3.49e-03	0.03940	14/135	DRAXIN; POU3F1; ARPC5; CNTN2; ID2; ZEB2; NEUROD1; CTNNB1; ROBO1; CASP3; POU3F4; EMX2; TACC2; SSTR2
GO:0090066	regulation of anatomical structure size	2.21	1.62e-03	0.02591	17/167	DRAXIN; CRABP2; ARPC5; CNTN2; CDC42EP3; MAP2; WDR1; MAP1B; TMSB4X; VAV2; OLFM1; ILK; CFL1; LIMA1; PFN1; DCC; PREX1
GO:0016049	cell growth	2.18	1.37e-03	0.02271	18/179	DRAXIN; CRABP2; ZEB2; MAP2; CTNNB1; ALCAM; CAMK2D; SORBS2; MAP1B; OLFM1; ILK; GAL; VCL; SYT1; AKAP6; EPB41L3; SYT4; DCC
GO:0051493	regulation of cytoskeleton organization	2.13	5.62e-04	0.01493	22/224	STMN1; RHOC; NES; ARPC5; CDC42EP3; RND3; MAP2; CTNNB1; CD47; WDR1; MEF2C; TMSB4X; STMN4; ILK; CFL1; RPS3; BICD1; LIMA1; PKD1; PFN1; MAPRE2; PREX1
GO:0009636	response to toxic substance	2.05	4.60e-03	0.04758	16/169	JUN; EPHX1; CHRNA1; EEF1B2; CASP3; SPARC; HDAC2; ACTB; PON2; TNC; RPS3; ASIC1; CALM1; ACTC1; NXN; MT-ND4

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Factor 11 : 8 significant GO terms

GeneSet	description	enrichRatio	pValue	FDR	GeneRatio	geneSymbols
GO:0006959	humoral immune response	13.50	2.61e-05	3.83e-03	5/24	HMGN2; RPL39; CD59; GAPDH; RPS19
GO:0001906	cell killing	11.60	5.75e-05	7.03e-03	5/28	HMGN2; PRDX1; TUBB; GAPDH; RPS19
GO:0006413	translational initiation	7.42	1.14e-11	8.37e-09	18/157	RPL37A; RPL35A; RPL37; RPS10; RPS12; RPL39; EIF4EBP1; RPL12; RPS24; RPL21; EIF5; RPS2; EIF1; RPL27; EIF2S2; RPS19; RPS11; ATF4
GO:0070972	protein localization to endoplasmic reticulum	7.07	2.13e-08	7.82e-06	13/119	RPL37A; RPL35A; RPL37; RPS10; RPS12; RPL39; RPL12; RPS24; RPL21; RPS2; RPL27; RPS19; RPS11
GO:0048871	multicellular organismal homeostasis	4.62	2.93e-04	2.69e-02	8/112	STMN1; PRDX1; NEUROD1; ACTB; GADD45G; DDIT3; DYNC1H1; ATF4
GO:0090150	establishment of protein localization to membrane	4.44	2.02e-06	4.94e-04	14/204	RPL37A; RPL35A; RPL37; GNB2L1; RPS10; RPS12; RPL39; RPL12; RPS24; RPL21; RPS2; RPL27; RPS19; RPS11
GO:0006401	RNA catabolic process	3.84	1.12e-05	2.05e-03	14/236	RPL37A; RPL35A; RPL37; RPS10; RPS12; RPL39; RPL12; RPS24; RPL21; SLIRP; RPS2; RPL27; RPS19; RPS11
GO:0006605	protein targeting	3.22	1.48e-04	1.55e-02	13/261	RPL37A; RPL35A; RPL37; RPS10; RPS12; RPL39; RPL12; RPS24; RPL21; RPS2; RPL27; RPS19; RPS11

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Factor 13 : 2 significant GO terms

GeneSet	description	enrichRatio	pValue	FDR	GeneRatio	geneSymbols
GO:0015844	monoamine transport	45.7	3.21e-05	0.0141	3/17	ACTB; SNCG; SYT1
GO:0034109	homotypic cell-cell adhesion	43.1	3.85e-05	0.0141	3/18	CLIC1; ACTB; ACTG1

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Factor 15 : 20 significant GO terms

GeneSet	description	enrichRatio	pValue	FDR	GeneRatio	geneSymbols
GO:0015844	monoamine transport	14.90	1.38e-05	0.00748	5/17	SNCA; ACTB; GPM6B; SYT1; SYT4
GO:0034109	homotypic cell-cell adhesion	11.30	3.52e-04	0.02169	4/18	ACTB; HSPB1; ACTG1; MYL12A
GO:0060191	regulation of lipase activity	10.70	4.39e-04	0.02169	4/19	HPCA; RHOC; SNCA; NTF3
GO:0015696	ammonium transport	8.82	9.44e-04	0.03829	4/23	SNCA; GPM6B; SYT1; SYT4
GO:2001023	regulation of response to drug	8.74	2.20e-04	0.02169	5/29	NFE2L2; SNCA; GAL; SYT1; SYT4
GO:0050905	neuromuscular process	6.50	9.11e-04	0.03829	5/39	CHRNA1; NEUROG1; NEFL; POU4F1; IGDCC3
GO:0043583	ear development	6.21	3.55e-04	0.02169	6/49	HPCA; NEUROD1; NEUROG1; SPARC; FAM65B; CTHRC1
GO:0015893	drug transport	6.04	1.28e-03	0.04714	5/42	SNCA; SLC25A6; GAL; SYT1; SYT4
GO:0015850	organic hydroxy compound transport	5.96	4.43e-04	0.02169	6/51	SNCA; ACTB; GPM6B; GAL; SYT1; SYT4
GO:0010959	regulation of metal ion transport	5.12	2.04e-05	0.00748	10/99	HPCA; ATP2B4; SNCA; SRI; GAL; REM2; B2M; NKAIN4; FXYD7; HRC
GO:0032409	regulation of transporter activity	5.01	1.69e-04	0.02062	8/81	HPCA; SNCA; ACTB; SRI; GAL; REM2; FXYD7; HRC
GO:0007517	muscle organ development	4.69	4.37e-05	0.01042	10/108	CHRNA1; BASP1; NEUROG1; FAM65B; UQCC2; SRI; CNTFR; MYL6; POU4F1; EFNB2
GO:0048880	sensory system development	4.66	1.15e-04	0.01686	9/98	HPCA; NES; ATP2B4; SIX3; NEUROD1; MAB21L2; NEUROD4; POU4F1; CELF4
GO:0009914	hormone transport	4.61	3.01e-04	0.02169	8/88	NEUROD1; FOXD1; SOX4; UQCC2; SRI; SLC25A6; GAL; DYNLL1
GO:0050878	regulation of body fluid levels	4.02	7.66e-04	0.03516	8/101	NFE2L2; CDO1; NEUROG1; ACTB; HSPB1; ZNF385A; ACTG1; MYL12A
GO:0034765	regulation of ion transmembrane transport	3.90	4.43e-04	0.02169	9/117	HPCA; ATP2B4; SCN9A; SNCA; SRI; GAL; REM2; FXYD7; HRC
GO:0051047	positive regulation of secretion	3.86	9.91e-04	0.03829	8/105	SNCA; SOX4; SRI; GAL; CADM1; SYT1; DYNLL1; SYT4
GO:0023061	signal release	3.83	5.68e-05	0.01042	12/159	NEUROD1; SNCA; FOXD1; SOX4; UQCC2; SRI; SLC25A6; GAL; ASIC1; SYT1; DYNLL1; SYT4
GO:0051098	regulation of binding	3.36	3.73e-04	0.02169	11/166	EPB41; NES; NEUROD1; FAM65B; ACTB; SRI; CTHRC1; POU4F1; B2M; CCPG1; WFIKKN1
GO:0009636	response to toxic substance	3.30	4.36e-04	0.02169	11/169	HPCA; PRDX1; SCN9A; CHRNA1; NFE2L2; CDO1; SPARC; ACTB; NEFL; RPS3; ASIC1

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Factor 16 : 2 significant GO terms

GeneSet	description	enrichRatio	pValue	FDR	GeneRatio	geneSymbols
GO:0060560	developmental growth involved in morphogenesis	4.22	1.08e-04	0.03980	10/89	DRAXIN; CRABP2; ZEB2; NRP2; ALCAM; MAP1B; TNC; GAL; SYT1; SYT4
GO:0061564	axon development	3.45	1.73e-06	0.00127	19/207	DRAXIN; EPHB2; JUN; S100A6; CRABP2; CNTN2; ZEB2; NRP2; ALCAM; GAP43; SPON2; CASP3; MAP1B; ETV1; NEFM; NEFL; TNC; FEZ1; MAP1A

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Factor 17 : 2 significant GO terms

GeneSet	description	enrichRatio	pValue	FDR	GeneRatio	geneSymbols
GO:0009141	nucleoside triphosphate metabolic process	4.22	1.98e-05	0.00997	12/189	ENO1; ATP5I; TMSB4X; UQCRB; LDHA; NDUFC2; HSPA8; ATP5B; PKM; COX4I1; ATP5E; UQCR10
GO:0009123	nucleoside monophosphate metabolic process	4.09	2.72e-05	0.00997	12/195	ENO1; ATP5I; TMSB4X; UQCRB; LDHA; NDUFC2; HSPA8; ATP5B; PKM; COX4I1; ATP5E; UQCR10

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Factor 18 : 12 significant GO terms

GeneSet	description	enrichRatio	pValue	FDR	GeneRatio	geneSymbols
GO:0070972	protein localization to endoplasmic reticulum	30.60	0.00e+00	0.00e+00	77/119	RPL22; RPL11; RPS8; RPL5; RPS27; RPS7; RPS27A; RPL31; RPL37A; RPL32; RPL15; RPSA; RPL14; RPL29; RPL24; RPL35A; RPL9; RPL34; RPS3A; RPL37; RPS23; RPS14; RPS18; RPS10; RPL10A; RPS12; RPS4X; RPL36A; RPL39; RPL10; RPS20; RPL7; RPL30; RPL8; RPS6; RPL35; RPL12; RPL7A; RPLP2; RPL27A; RPS13; RPS3; RPS25; RPS24; RPL41; RPL6; RPLP0; RPL21; RPS29; RPL4; RPLP1; RPS17; RPS2; RPS15A; RPL13; RPL26; RPL23A; RPL23; RPL19; RPL27; RPL38; RPL17; RPS21; RPS15; RPL36; RPS28; RPL18A; UBA52; RPS16; RPS19; RPL18; RPL13A; RPS11; RPS9; RPL28; RPS5; RPL3
GO:0006413	translational initiation	23.20	0.00e+00	0.00e+00	77/157	RPL22; RPL11; RPS8; RPL5; RPS27; RPS7; RPS27A; RPL31; RPL37A; RPL32; RPL15; RPSA; RPL14; RPL29; RPL24; RPL35A; RPL9; RPL34; RPS3A; RPL37; RPS23; RPS14; RPS18; RPS10; RPL10A; RPS12; RPS4X; RPL36A; RPL39; RPL10; RPS20; RPL7; RPL30; RPL8; RPS6; RPL35; RPL12; RPL7A; RPLP2; RPL27A; RPS13; RPS3; RPS25; RPS24; RPL41; RPL6; RPLP0; RPL21; RPS29; RPL4; RPLP1; RPS17; RPS2; RPS15A; RPL13; RPL26; RPL23A; RPL23; RPL19; RPL27; RPL38; RPL17; RPS21; RPS15; RPL36; RPS28; RPL18A; UBA52; RPS16; RPS19; RPL18; RPL13A; RPS11; RPS9; RPL28; RPS5; RPL3
GO:0002181	cytoplasmic translation	19.40	0.00e+00	0.00e+00	30/73	RPL11; RPL31; RPL32; RPL15; RPL29; RPL24; RPL35A; RPL9; RPS23; RPL10A; RPL36A; RPL39; RPL30; RPL8; RPL41; RPL6; RPLP0; RPS29; RPLP1; RPL26; RPL19; RPL38; RPL17; RPS21; EEF2; RPL36; RPS28; RPL18A; RPL18; RPL13A
GO:0090150	establishment of protein localization to membrane	18.10	0.00e+00	0.00e+00	78/204	RPL22; RPL11; RPS8; RPL5; RPS27; RPS7; RPS27A; RPL31; RPL37A; RPL32; RPL15; RPSA; RPL14; RPL29; RPL24; RPL35A; RPL9; RPL34; RPS3A; RPL37; RPS23; RPS14; GNB2L1; RPS18; RPS10; RPL10A; RPS12; RPS4X; RPL36A; RPL39; RPL10; RPS20; RPL7; RPL30; RPL8; RPS6; RPL35; RPL12; RPL7A; RPLP2; RPL27A; RPS13; RPS3; RPS25; RPS24; RPL41; RPL6; RPLP0; RPL21; RPS29; RPL4; RPLP1; RPS17; RPS2; RPS15A; RPL13; RPL26; RPL23A; RPL23; RPL19; RPL27; RPL38; RPL17; RPS21; RPS15; RPL36; RPS28; RPL18A; UBA52; RPS16; RPS19; RPL18; RPL13A; RPS11; RPS9; RPL28; RPS5; RPL3
GO:0006401	RNA catabolic process	15.80	0.00e+00	0.00e+00	79/236	RPL22; RPL11; YBX1; RPS8; RPL5; RPS27; RPS7; RPS27A; RPL31; RPL37A; RPL32; RPL15; RPSA; RPL14; RPL29; RPL24; RPL35A; RPL9; RPL34; RPS3A; RPL37; RPS23; RPS14; RPS18; RPS10; RPL10A; RPS12; RPS4X; RPL36A; RPL39; RPL10; RPS20; RPL7; RPL30; RPL8; RPS6; RPL35; RPL12; RPL7A; RPLP2; RPL27A; RPS13; RPS3; RPS25; RPS24; RPL41; RPL6; RPLP0; RPL21; RPS29; RPL4; RPLP1; RPS17; RPS2; RPS15A; RPL13; RPL26; RPL23A; RPL23; RPL19; RPL27; DDX5; RPL38; RPL17; RPS21; RPS15; RPL36; RPS28; RPL18A; UBA52; RPS16; RPS19; RPL18; RPL13A; RPS11; RPS9; RPL28; RPS5; RPL3
GO:0006605	protein targeting	14.10	0.00e+00	0.00e+00	78/261	RPL22; RPL11; RPS8; RPL5; RPS27; RPS7; RPS27A; RPL31; RPL37A; RPL32; RPL15; RPSA; RPL14; RPL29; RPL24; RPL35A; RPL9; RPL34; RPS3A; RPL37; RPS23; RPS14; RPS18; RPS10; RPL10A; RPS12; SLC25A6; RPS4X; RPL36A; RPL39; RPL10; RPS20; RPL7; RPL30; RPL8; RPS6; RPL35; RPL12; RPL7A; RPLP2; RPL27A; RPS13; RPS3; RPS25; RPS24; RPL41; RPL6; RPLP0; RPL21; RPS29; RPL4; RPLP1; RPS17; RPS2; RPS15A; RPL13; RPL26; RPL23A; RPL23; RPL19; RPL27; RPL38; RPL17; RPS21; RPS15; RPL36; RPS28; RPL18A; UBA52; RPS16; RPS19; RPL18; RPL13A; RPS11; RPS9; RPL28; RPS5; RPL3
GO:0016072	rRNA metabolic process	6.91	4.22e-15	3.87e-13	25/171	RPL11; RPS8; RPL5; RPS27; RPS7; RPSA; RPL14; RPL35A; RPS14; RPL10A; RPL7; RPS6; RPL35; RPL7A; RPS24; RPS17; RPS2; RPL26; RPL27; RPS21; RPS15; RPS28; RPS16; RPS19; RPS9
GO:0022613	ribonucleoprotein complex biogenesis	5.30	0.00e+00	0.00e+00	37/330	RPL11; RPS8; RPL5; RPS27; RPS7; RPSA; RPL14; RPL24; RPL35A; RPS23; RPS14; RPS10; RPL10A; RPL10; RPL7; RPS6; RPL35; RPL12; RPL7A; RPS24; RPL6; RPLP0; RPS17; RPS2; RPL26; RPL23A; RPL27; RPL38; RPS21; RPS15; RPS28; RPS16; RPS19; RPL13A; RPS9; RPS5; RPL3
GO:0034470	ncRNA processing	5.30	2.16e-12	1.76e-10	25/223	RPL11; RPS8; RPL5; RPS27; RPS7; RPSA; RPL14; RPL35A; RPS14; RPL10A; RPL7; RPS6; RPL35; RPL7A; RPS24; RPS17; RPS2; RPL26; RPL27; RPS21; RPS15; RPS28; RPS16; RPS19; RPS9
GO:0071826	ribonucleoprotein complex subunit organization	5.11	9.40e-10	6.90e-08	20/185	RPL11; RPL5; RPS27; RPSA; RPL24; RPS23; RPS14; RPS10; RPL10; RPL12; RPL6; RPLP0; RPL23A; RPL38; RPS15; RPS28; RPS19; RPL13A; RPS5; RPL3
GO:0034248	regulation of cellular amide metabolic process	2.92	2.60e-04	1.59e-02	14/227	RPL5; RPS14; GNB2L1; SOX4; EEF1A1; RPS4X; RPL10; RPS3; GAPDH; RPL26; RPL38; EEF2; RPL13A; RPS9
GO:0010608	posttranscriptional regulation of gene expression	2.81	8.45e-05	5.64e-03	17/286	YBX1; RPL5; RPS27A; RPS14; GNB2L1; SOX4; RPS4X; RPL10; RPS3; GAPDH; RPL26; DDX5; RPL38; EEF2; UBA52; RPL13A; RPS9

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Factor 19 : 11 significant GO terms

GeneSet	description	enrichRatio	pValue	FDR	GeneRatio	geneSymbols
GO:0070972	protein localization to endoplasmic reticulum	12.30	0.00e+00	0.00e+00	28/119	RPL5; SRP9; RPS7; RPL37A; RPL15; RPSA; RPL14; RPS3A; RPL10A; RPS4X; RPL10; RPS20; RPL7; RPL35; RPL7A; RPS3; RPL41; RPL6; RPS29; RPL4; RPS2; RPL23; RPL36; RPS28; KDELR1; RPL13A; RPS9; RPL3
GO:0006413	translational initiation	11.30	0.00e+00	0.00e+00	34/157	RPL5; RPS7; RPL37A; RPL15; RPSA; RPL14; EIF4A2; RPS3A; NPM1; RPL10A; RPS4X; RPL10; RPS20; RPL7; EIF3E; EIF3H; RPL35; RPL7A; EIF3F; EIF3M; RPS3; RPL41; RPL6; RPS29; RPL4; RPS2; RPL23; RPL36; RPS28; RPL13A; RPS9; EIF3D; EIF3L; RPL3
GO:0002181	cytoplasmic translation	10.80	3.13e-12	3.82e-10	15/73	RPL15; RPL10A; EIF3E; EIF3H; EIF3F; EIF3M; RPL41; RPL6; RPS29; EEF2; RPL36; RPS28; RPL13A; EIF3D; EIF3L
GO:0090150	establishment of protein localization to membrane	7.44	0.00e+00	0.00e+00	29/204	RPL5; SRP9; RPS7; RPL37A; RPL15; RPSA; RPL14; RPS3A; GNB2L1; RPL10A; RPS4X; RPL10; RPS20; RPL7; RPL35; RPL7A; RPS3; RPL41; RPL6; RPS29; HSP90AA1; RPL4; RPS2; RPL23; RPL36; RPS28; RPL13A; RPS9; RPL3
GO:0006401	RNA catabolic process	6.65	0.00e+00	0.00e+00	30/236	YBX1; RPL5; RPS7; RPL37A; RPL15; RPSA; RPL14; RPS3A; NPM1; RPL10A; RPS4X; RPL10; RPS20; RPL7; EIF3E; RPL35; RPL7A; RPS3; RPL41; RPL6; RPS29; RPL4; RPS2; RPL23; CIRBP; RPL36; RPS28; RPL13A; RPS9; RPL3
GO:0006605	protein targeting	5.81	1.55e-15	2.28e-13	29/261	RPL5; SRP9; RPS7; RPL37A; RPL15; RPSA; RPL14; RPS3A; RPL10A; SLC25A6; RPS4X; RPL10; RPS20; RPL7; RPL35; RPL7A; RPS3; RPL41; RPL6; RPS29; HSP90AA1; RPL4; RPS2; RPL23; RPL36; RPS28; RPL13A; RPS9; RPL3
GO:0071826	ribonucleoprotein complex subunit organization	5.09	7.36e-09	6.75e-07	18/185	RPL5; RPSA; NPM1; RBMX; RPL10; EIF3E; EIF3H; EIF3F; EIF3M; RPL6; HSP90AA1; CIRBP; RPS28; GLTSCR2; RPL13A; EIF3D; EIF3L; RPL3
GO:0022613	ribonucleoprotein complex biogenesis	4.12	1.96e-10	2.05e-08	26/330	RPL5; RPS7; RPSA; RPL14; NPM1; RPL10A; RBMX; RPL10; RPL7; EIF3E; EIF3H; RPL35; RPL7A; EIF3F; EIF3M; RPL6; HSP90AA1; RPS2; CIRBP; RPS28; GLTSCR2; RPL13A; RPS9; EIF3D; EIF3L; RPL3
GO:0034248	regulation of cellular amide metabolic process	3.92	9.48e-07	7.73e-05	17/227	RPL5; SRP9; EIF4A2; NPM1; GNB2L1; EEF1A1; RBM3; RPS4X; RPL10; EIF3E; EIF3H; RPS3; CIRBP; EEF2; RPL13A; RPS9; EIF3D
GO:0016072	rRNA metabolic process	3.67	8.45e-05	5.64e-03	12/171	RPL5; RPS7; RPSA; RPL14; RPL10A; RPL7; RPL35; RPL7A; RPS2; RPS28; GLTSCR2; RPS9
GO:0010608	posttranscriptional regulation of gene expression	3.29	5.45e-06	4.00e-04	18/286	YBX1; RPL5; SRP9; H3F3A; EIF4A2; NPM1; GNB2L1; RBM3; RPS4X; RPL10; EIF3E; EIF3H; RPS3; CIRBP; EEF2; RPL13A; RPS9; EIF3D

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Summary:

Factor	1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	19
Signif_GO_terms	12	44	12	56	13	4	21	7	72	0	8	0	2	0	20	2	2	12	11

5.1.1 Factors of interest

4, 9, 15, 16

5.2 Reactome Pathway Over-Representation Analysis

Gene sets: The Reactome pathway database.

Factor 1 : 165 significant Reactome pathways

GeneSet	description	enrichRatio	pValue	FDR	GeneRatio	geneSymbols
R-HSA-8876725	Protein methylation	5.34	1.40e-03	8.12e-03	5/12	CALM2; EEF1A1; RPS2; EEF2; CALM3
R-HSA-450604	KSRP (KHSRP) binds and destabilizes mRNA	5.34	1.40e-03	8.12e-03	5/12	EXOSC7; YWHAZ; EXOSC4; EXOSC1; EXOSC8
R-HSA-392851	Prostacyclin signalling through prostacyclin receptor	5.13	5.21e-03	2.68e-02	4/10	GNG3; GNG2; GNAS; GNG8
R-HSA-420092	Glucagon-type ligand receptors	5.13	5.21e-03	2.68e-02	4/10	GNG3; GNG2; GNAS; GNG8
R-HSA-445095	Interaction between L1 and Ankyrins	5.13	5.84e-04	3.70e-03	6/15	NFASC; SCN3A; ANK2; SPTAN1; ANK3; ACTG1
R-HSA-373080	Class B/2 (Secretin family receptors)	4.93	2.12e-03	1.18e-02	5/13	GNG3; GNG2; GNAS; GNG8; PTH2
R-HSA-3000178	ECM proteoglycans	4.93	2.12e-03	1.18e-02	5/13	VCAN; TNC; NCAM1; APP; COL6A1
R-HSA-5419276	Mitochondrial translation termination	4.59	3.70e-13	1.53e-10	29/81	MRPL37; MRPL9; MRPS9; MRPS22; MRPL47; MRPS18C; MRPS30; MRPL22; MRPS18B; MRPS10; MRPL2; MRPS18A; MRPL32; MRPL15; MRPL50; MRPS2; MRPL21; MRPL51; MRPL42; MRPL46; MRPS11; MRPS34; MRPL27; ICT1; MRPS7; MRPL12; MRPS26; GADD45GIP1; MRPL39
R-HSA-5368286	Mitochondrial translation initiation	4.53	5.33e-13	1.53e-10	29/82	MRPL37; MRPL9; MRPS9; MRPS22; MRPL47; MRPS18C; MRPS30; MRPL22; MRPS18B; MRPS10; MRPL2; MRPS18A; MRPL32; MRPL15; MRPL50; MRPS2; MRPL21; MRPL51; MRPL42; MRPL46; MRPS11; MRPS34; MRPL27; ICT1; MRPS7; MRPL12; MRPS26; GADD45GIP1; MRPL39
R-HSA-380994	ATF4 activates genes	4.53	1.26e-03	7.60e-03	6/17	EXOSC7; EXOSC4; EXOSC1; DDIT3; EXOSC8; ATF4
R-HSA-5389840	Mitochondrial translation elongation	4.48	7.63e-13	1.64e-10	29/83	MRPL37; MRPL9; MRPS9; MRPS22; MRPL47; MRPS18C; MRPS30; MRPL22; MRPS18B; MRPS10; MRPL2; MRPS18A; MRPL32; MRPL15; MRPL50; MRPS2; MRPL21; MRPL51; MRPL42; MRPL46; MRPS11; MRPS34; MRPL27; ICT1; MRPS7; MRPL12; MRPS26; GADD45GIP1; MRPL39
R-HSA-5368287	Mitochondrial translation	4.32	2.15e-12	3.71e-10	29/86	MRPL37; MRPL9; MRPS9; MRPS22; MRPL47; MRPS18C; MRPS30; MRPL22; MRPS18B; MRPS10; MRPL2; MRPS18A; MRPL32; MRPL15; MRPL50; MRPS2; MRPL21; MRPL51; MRPL42; MRPL46; MRPS11; MRPS34; MRPL27; ICT1; MRPS7; MRPL12; MRPS26; GADD45GIP1; MRPL39
R-HSA-69229	Ubiquitin-dependent degradation of Cyclin D1	4.08	3.01e-06	8.95e-05	14/44	PSMD4; RPS27A; PSMB1; PSMA2; PSMB7; CDK4; PSMB5; PSMA3; PSMC1; PSMA4; PSMB6; PSMA7; PSMD8; PSMC4
R-HSA-75815	Ubiquitin-dependent degradation of Cyclin D	4.08	3.01e-06	8.95e-05	14/44	PSMD4; RPS27A; PSMB1; PSMA2; PSMB7; CDK4; PSMB5; PSMA3; PSMC1; PSMA4; PSMB6; PSMA7; PSMD8; PSMC4
R-HSA-389957	Prefoldin mediated transfer of substrate to CCT/TriC	4.08	9.98e-04	6.09e-03	7/22	PFDN2; CCT5; PFDN1; TUBB2B; CCT6A; TUBA1A; PFDN4
R-HSA-381042	PERK regulates gene expression	4.05	2.42e-03	1.30e-02	6/19	EXOSC7; EXOSC4; EXOSC1; DDIT3; EXOSC8; ATF4
R-HSA-451326	Activation of kainate receptors upon glutamate binding	4.01	5.93e-03	3.02e-02	5/16	CALM2; GNG3; GNG2; CALM3; GNG8
R-HSA-1236978	Cross-presentation of soluble exogenous antigens (endosomes)	3.95	2.30e-05	3.42e-04	12/39	PSMD4; PSMB1; PSMA2; PSMB7; PSMB5; PSMA3; PSMC1; PSMA4; PSMB6; PSMA7; PSMD8; PSMC4
R-HSA-5578775	Ion homeostasis	3.90	1.34e-03	7.91e-03	7/23	ATP1B1; CALM2; SRI; FXYD6; ATP2B1; FXYD7; CALM3
R-HSA-389958	Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding	3.90	1.34e-03	7.91e-03	7/23	PFDN2; CCT5; PFDN1; TUBB2B; CCT6A; TUBA1A; PFDN4
R-HSA-180534	Vpu mediated degradation of CD4	3.88	1.29e-05	2.37e-04	13/43	PSMD4; RPS27A; PSMB1; PSMA2; PSMB7; PSMB5; PSMA3; PSMC1; PSMA4; PSMB6; PSMA7; PSMD8; PSMC4
R-HSA-211733	Regulation of activated PAK-2p34 by proteasome mediated degradation	3.88	1.29e-05	2.37e-04	13/43	PSMD4; RPS27A; PSMB1; PSMA2; PSMB7; PSMB5; PSMA3; PSMC1; PSMA4; PSMB6; PSMA7; PSMD8; PSMC4
R-HSA-69601	Ubiquitin Mediated Degradation of Phosphorylated Cdc25A	3.88	1.29e-05	2.37e-04	13/43	PSMD4; RPS27A; PSMB1; PSMA2; PSMB7; PSMB5; PSMA3; PSMC1; PSMA4; PSMB6; PSMA7; PSMD8; PSMC4
R-HSA-69610	p53-Independent DNA Damage Response	3.88	1.29e-05	2.37e-04	13/43	PSMD4; RPS27A; PSMB1; PSMA2; PSMB7; PSMB5; PSMA3; PSMC1; PSMA4; PSMB6; PSMA7; PSMD8; PSMC4
R-HSA-69613	p53-Independent G1/S DNA damage checkpoint	3.88	1.29e-05	2.37e-04	13/43	PSMD4; RPS27A; PSMB1; PSMA2; PSMB7; PSMB5; PSMA3; PSMC1; PSMA4; PSMB6; PSMA7; PSMD8; PSMC4
R-HSA-187577	SCF(Skp2)-mediated degradation of p27/p21	3.82	7.23e-06	1.78e-04	14/47	PSMD4; RPS27A; PSMB1; PSMA2; PSMB7; CDK4; PSMB5; PSMA3; PSMC1; PSMA4; PSMB6; PSMA7; PSMD8; PSMC4
R-HSA-450408	AUF1 (hnRNP D0) binds and destabilizes mRNA	3.82	7.23e-06	1.78e-04	14/47	PSMD4; RPS27A; PSMB1; PSMA2; HSPB1; PSMB7; PSMB5; PSMA3; PSMC1; PSMA4; PSMB6; PSMA7; PSMD8; PSMC4
R-HSA-9604323	Negative regulation of NOTCH4 signaling	3.82	7.23e-06	1.78e-04	14/47	PSMD4; RPS27A; PSMB1; PSMA2; YWHAZ; PSMB7; PSMB5; PSMA3; PSMC1; PSMA4; PSMB6; PSMA7; PSMD8; PSMC4
R-HSA-500792	GPCR ligand binding	3.80	7.40e-04	4.62e-03	8/27	GNG3; PSAP; GNG2; SSTR2; GNAS; GNG8; PTH2; APP
R-HSA-169911	Regulation of Apoptosis	3.79	1.71e-05	2.94e-04	13/44	PSMD4; RPS27A; PSMB1; PSMA2; PSMB7; PSMB5; PSMA3; PSMC1; PSMA4; PSMB6; PSMA7; PSMD8; PSMC4
R-HSA-174113	SCF-beta-TrCP mediated degradation of Emi1	3.79	1.71e-05	2.94e-04	13/44	PSMD4; RPS27A; PSMB1; PSMA2; PSMB7; PSMB5; PSMA3; PSMC1; PSMA4; PSMB6; PSMA7; PSMD8; PSMC4
R-HSA-72695	Formation of the ternary complex, and subsequently, the 43S complex	3.74	9.50e-06	2.23e-04	14/48	EIF3I; RPS7; RPS27A; RPSA; RPS10; RPS12; RPS6; RPS29; RPS27L; RPS17; RPS2; RPS19; RPS5
R-HSA-936837	Ion transport by P-type ATPases	3.74	1.77e-03	1.00e-02	7/24	ATP1B1; CALM2; SRI; FXYD6; ATP2B1; FXYD7; CALM3
R-HSA-349425	Autodegradation of the E3 ubiquitin ligase COP1	3.70	2.24e-05	3.42e-04	13/45	PSMD4; RPS27A; PSMB1; PSMA2; PSMB7; PSMB5; PSMA3; PSMC1; PSMA4; PSMB6; PSMA7; PSMD8; PSMC4
R-HSA-4641258	Degradation of DVL	3.70	2.24e-05	3.42e-04	13/45	PSMD4; RPS27A; PSMB1; PSMA2; PSMB7; PSMB5; PSMA3; PSMC1; PSMA4; PSMB6; PSMA7; PSMD8; PSMC4
R-HSA-68827	CDT1 association with the CDC6:ORC:origin complex	3.70	2.24e-05	3.42e-04	13/45	PSMD4; RPS27A; PSMB1; PSMA2; PSMB7; PSMB5; PSMA3; PSMC1; PSMA4; PSMB6; PSMA7; PSMD8; PSMC4
R-HSA-8854050	FBXL7 down-regulates AURKA during mitotic entry and in early mitosis	3.70	2.24e-05	3.42e-04	13/45	PSMD4; RPS27A; PSMB1; PSMA2; PSMB7; PSMB5; PSMA3; PSMC1; PSMA4; PSMB6; PSMA7; PSMD8; PSMC4
R-HSA-8941858	Regulation of RUNX3 expression and activity	3.70	2.24e-05	3.42e-04	13/45	PSMD4; RPS27A; PSMB1; PSMA2; PSMB7; PSMB5; PSMA3; PSMC1; PSMA4; PSMB6; PSMA7; PSMD8; PSMC4
R-HSA-156902	Peptide chain elongation	3.66	8.65e-09	7.45e-07	24/84	RPS7; RPS27A; RPSA; RPL9; RPL37; RPS10; EEF1A1; RPS12; RPL10; RPS6; RPL41; RPS29; RPS27L; RPS17; RPS2; RPL13; RPL23A; RPL19; RPL27; EEF2; RPS19; RPL13A; RPS5
R-HSA-180585	Vif-mediated degradation of APOBEC3G	3.62	2.90e-05	4.10e-04	13/46	PSMD4; RPS27A; PSMB1; PSMA2; PSMB7; PSMB5; PSMA3; PSMC1; PSMA4; PSMB6; PSMA7; PSMD8; PSMC4
R-HSA-4641257	Degradation of AXIN	3.62	2.90e-05	4.10e-04	13/46	PSMD4; RPS27A; PSMB1; PSMA2; PSMB7; PSMB5; PSMA3; PSMC1; PSMA4; PSMB6; PSMA7; PSMD8; PSMC4
R-HSA-450531	Regulation of mRNA stability by proteins that bind AU-rich elements	3.58	4.87e-07	2.00e-05	19/68	PSMD4; RPS27A; EXOSC7; PSMB1; PSMA2; HSPB1; YWHAZ; EXOSC4; PSMB7; EXOSC1; EXOSC8; PSMB5; PSMA3; PSMC1; PSMA4; PSMB6; PSMA7; PSMD8; PSMC4
R-HSA-156842	Eukaryotic Translation Elongation	3.58	1.45e-08	1.03e-06	24/86	RPS7; RPS27A; RPSA; RPL9; RPL37; RPS10; EEF1A1; RPS12; RPL10; RPS6; RPL41; RPS29; RPS27L; RPS17; RPS2; RPL13; RPL23A; RPL19; RPL27; EEF2; RPS19; RPL13A; RPS5
R-HSA-350562	Regulation of ornithine decarboxylase (ODC)	3.58	6.80e-05	6.97e-04	12/43	PSMD4; PSMB1; PSMA2; PSMB7; PSMB5; PSMA3; PSMC1; PSMA4; PSMB6; PSMA7; PSMD8; PSMC4
R-HSA-5362768	Hh mutants that don't undergo autocatalytic processing are degraded by ERAD	3.55	3.74e-05	4.73e-04	13/47	PSMD4; RPS27A; PSMB1; PSMA2; PSMB7; PSMB5; PSMA3; PSMC1; PSMA4; PSMB6; PSMA7; PSMD8; PSMC4
R-HSA-5387390	Hh mutants abrogate ligand secretion	3.55	3.74e-05	4.73e-04	13/47	PSMD4; RPS27A; PSMB1; PSMA2; PSMB7; PSMB5; PSMA3; PSMC1; PSMA4; PSMB6; PSMA7; PSMD8; PSMC4
R-HSA-5607761	Dectin-1 mediated noncanonical NF-kB signaling	3.55	3.74e-05	4.73e-04	13/47	PSMD4; RPS27A; PSMB1; PSMA2; PSMB7; PSMB5; PSMA3; PSMC1; PSMA4; PSMB6; PSMA7; PSMD8; PSMC4
R-HSA-5676590	NIK-->noncanonical NF-kB signaling	3.55	3.74e-05	4.73e-04	13/47	PSMD4; RPS27A; PSMB1; PSMA2; PSMB7; PSMB5; PSMA3; PSMC1; PSMA4; PSMB6; PSMA7; PSMD8; PSMC4
R-HSA-68867	Assembly of the pre-replicative complex	3.55	3.74e-05	4.73e-04	13/47	PSMD4; RPS27A; PSMB1; PSMA2; PSMB7; PSMB5; PSMA3; PSMC1; PSMA4; PSMB6; PSMA7; PSMD8; PSMC4
R-HSA-1168372	Downstream signaling events of B Cell Receptor (BCR)	3.54	4.84e-06	1.30e-04	16/58	PSMD4; CALM2; RPS27A; PSMB1; PSMA2; PPIA; PSMB7; PSMB5; PSMA3; PSMC1; PSMA4; PSMB6; PSMA7; PSMD8; PSMC4; CALM3
R-HSA-8852276	The role of GTSE1 in G2/M progression after G2 checkpoint	3.50	1.13e-05	2.37e-04	15/55	PSMD4; RPS27A; TUBB2B; PSMB1; PSMA2; PSMB7; TUBA1A; PSMB5; PSMA3; PSMC1; PSMA4; PSMB6; PSMA7; PSMD8; PSMC4
R-HSA-72649	Translation initiation complex formation	3.50	1.13e-05	2.37e-04	15/55	EIF3I; RPS7; RPS27A; RPSA; RPS10; RPS12; RPS6; RPS29; RPS27L; RPS17; RPS2; EIF4A1; RPS19; RPS5
R-HSA-72702	Ribosomal scanning and start codon recognition	3.50	1.13e-05	2.37e-04	15/55	EIF3I; RPS7; RPS27A; RPSA; RPS10; RPS12; RPS6; RPS29; RPS27L; RPS17; RPS2; EIF4A1; RPS19; RPS5
R-HSA-68949	Orc1 removal from chromatin	3.47	4.77e-05	5.34e-04	13/48	PSMD4; RPS27A; PSMB1; PSMA2; PSMB7; PSMB5; PSMA3; PSMC1; PSMA4; PSMB6; PSMA7; PSMD8; PSMC4
R-HSA-1169091	Activation of NF-kappaB in B cells	3.47	4.77e-05	5.34e-04	13/48	PSMD4; RPS27A; PSMB1; PSMA2; PSMB7; PSMB5; PSMA3; PSMC1; PSMA4; PSMB6; PSMA7; PSMD8; PSMC4
R-HSA-4608870	Asymmetric localization of PCP proteins	3.47	4.77e-05	5.34e-04	13/48	PSMD4; RPS27A; PSMB1; PSMA2; PSMB7; PSMB5; PSMA3; PSMC1; PSMA4; PSMB6; PSMA7; PSMD8; PSMC4
R-HSA-5610780	Degradation of GLI1 by the proteasome	3.47	4.77e-05	5.34e-04	13/48	PSMD4; RPS27A; PSMB1; PSMA2; PSMB7; PSMB5; PSMA3; PSMC1; PSMA4; PSMB6; PSMA7; PSMD8; PSMC4
R-HSA-5668541	TNFR2 non-canonical NF-kB pathway	3.47	4.77e-05	5.34e-04	13/48	PSMD4; RPS27A; PSMB1; PSMA2; PSMB7; PSMB5; PSMA3; PSMC1; PSMA4; PSMB6; PSMA7; PSMD8; PSMC4
R-HSA-69541	Stabilization of p53	3.47	4.77e-05	5.34e-04	13/48	PSMD4; RPS27A; PSMB1; PSMA2; PSMB7; PSMB5; PSMA3; PSMC1; PSMA4; PSMB6; PSMA7; PSMD8; PSMC4
R-HSA-72662	Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S	3.43	1.43e-05	2.57e-04	15/56	EIF3I; RPS7; RPS27A; RPSA; RPS10; RPS12; RPS6; RPS29; RPS27L; RPS17; RPS2; EIF4A1; RPS19; RPS5
R-HSA-72764	Eukaryotic Translation Termination	3.43	7.08e-08	4.36e-06	23/86	RPS7; RPS27A; RPSA; RPL9; RPL37; RPS10; RPS12; RPL10; RPS6; TRMT112; RPL41; RPS29; RPS27L; RPS17; RPS2; RPL13; RPL23A; RPL19; RPL27; RPS19; RPL13A; RPS5
R-HSA-418346	Platelet homeostasis	3.42	1.59e-03	9.11e-03	8/30	CALM2; SRI; GNG3; ATP2B1; GNG2; GNAS; CALM3; GNG8
R-HSA-5610783	Degradation of GLI2 by the proteasome	3.40	6.05e-05	6.28e-04	13/49	PSMD4; RPS27A; PSMB1; PSMA2; PSMB7; PSMB5; PSMA3; PSMC1; PSMA4; PSMB6; PSMA7; PSMD8; PSMC4
R-HSA-5610785	GLI3 is processed to GLI3R by the proteasome	3.40	6.05e-05	6.28e-04	13/49	PSMD4; RPS27A; PSMB1; PSMA2; PSMB7; PSMB5; PSMA3; PSMC1; PSMA4; PSMB6; PSMA7; PSMD8; PSMC4
R-HSA-5678895	Defective CFTR causes cystic fibrosis	3.40	6.05e-05	6.28e-04	13/49	PSMD4; RPS27A; PSMB1; PSMA2; PSMB7; PSMB5; PSMA3; PSMC1; PSMA4; PSMB6; PSMA7; PSMD8; PSMC4
R-HSA-192823	Viral mRNA Translation	3.40	1.65e-07	8.86e-06	22/83	RPS7; RPS27A; RPSA; RPL9; RPL37; RPS10; RPS12; RPL10; RPS6; RPL41; RPS29; RPS27L; RPS17; RPS2; RPL13; RPL23A; RPL19; RPL27; RPS19; RPL13A; RPS5
R-HSA-1236974	ER-Phagosome pathway	3.33	7.61e-05	7.53e-04	13/50	PSMD4; RPS27A; PSMB1; PSMA2; PSMB7; PSMB5; PSMA3; PSMC1; PSMA4; PSMB6; PSMA7; PSMD8; PSMC4
R-HSA-5358346	Hedgehog ligand biogenesis	3.33	7.61e-05	7.53e-04	13/50	PSMD4; RPS27A; PSMB1; PSMA2; PSMB7; PSMB5; PSMA3; PSMC1; PSMA4; PSMB6; PSMA7; PSMD8; PSMC4
R-HSA-174154	APC/C:Cdc20 mediated degradation of Securin	3.32	4.16e-05	5.12e-04	14/54	PSMD4; RPS27A; PTTG1; PSMB1; PSMA2; PSMB7; PSMB5; PSMA3; PSMC1; PSMA4; PSMB6; PSMA7; PSMD8; PSMC4
R-HSA-174178	APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1	3.32	4.16e-05	5.12e-04	14/54	PSMD4; RPS27A; PTTG1; PSMB1; PSMA2; PSMB7; PSMB5; PSMA3; PSMC1; PSMA4; PSMB6; PSMA7; PSMD8; PSMC4
R-HSA-2408557	Selenocysteine synthesis	3.32	2.61e-07	1.32e-05	22/85	RPS7; RPS27A; RPSA; RPL9; RPL37; RPS10; RPS12; RPL10; RPS6; RPL41; RPS29; RPS27L; RPS17; RPS2; RPL13; RPL23A; RPL19; RPL27; RPS19; RPL13A; RPS5
R-HSA-9013694	Signaling by NOTCH4	3.32	2.27e-05	3.42e-04	15/58	PSMD4; RPS27A; PSMB1; PSMA2; YWHAZ; PSMB7; PSMB5; PSMA3; SNW1; PSMC1; PSMA4; PSMB6; PSMA7; PSMD8; PSMC4
R-HSA-5619084	ABC transporter disorders	3.27	9.52e-05	8.53e-04	13/51	PSMD4; RPS27A; PSMB1; PSMA2; PSMB7; PSMB5; PSMA3; PSMC1; PSMA4; PSMB6; PSMA7; PSMD8; PSMC4
R-HSA-1236975	Antigen processing-Cross presentation	3.27	9.52e-05	8.53e-04	13/51	PSMD4; RPS27A; PSMB1; PSMA2; PSMB7; PSMB5; PSMA3; PSMC1; PSMA4; PSMB6; PSMA7; PSMD8; PSMC4
R-HSA-8939902	Regulation of RUNX2 expression and activity	3.27	9.52e-05	8.53e-04	13/51	PSMD4; RPS27A; PSMB1; PSMA2; PSMB7; PSMB5; PSMA3; PSMC1; PSMA4; PSMB6; PSMA7; PSMD8; PSMC4
R-HSA-176409	APC/C:Cdc20 mediated degradation of mitotic proteins	3.26	5.20e-05	5.66e-04	14/55	PSMD4; RPS27A; PTTG1; PSMB1; PSMA2; PSMB7; PSMB5; PSMA3; PSMC1; PSMA4; PSMB6; PSMA7; PSMD8; PSMC4
R-HSA-176814	Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins	3.26	5.20e-05	5.66e-04	14/55	PSMD4; RPS27A; PTTG1; PSMB1; PSMA2; PSMB7; PSMB5; PSMA3; PSMC1; PSMA4; PSMB6; PSMA7; PSMD8; PSMC4
R-HSA-5658442	Regulation of RAS by GAPs	3.21	1.18e-04	9.69e-04	13/52	PSMD4; RPS27A; PSMB1; PSMA2; PSMB7; PSMB5; PSMA3; PSMC1; PSMA4; PSMB6; PSMA7; PSMD8; PSMC4
R-HSA-69002	DNA Replication Pre-Initiation	3.21	1.18e-04	9.69e-04	13/52	PSMD4; RPS27A; PSMB1; PSMA2; PSMB7; PSMB5; PSMA3; PSMC1; PSMA4; PSMB6; PSMA7; PSMD8; PSMC4
R-HSA-69563	p53-Dependent G1 DNA Damage Response	3.21	1.18e-04	9.69e-04	13/52	PSMD4; RPS27A; PSMB1; PSMA2; PSMB7; PSMB5; PSMA3; PSMC1; PSMA4; PSMB6; PSMA7; PSMD8; PSMC4
R-HSA-69580	p53-Dependent G1/S DNA damage checkpoint	3.21	1.18e-04	9.69e-04	13/52	PSMD4; RPS27A; PSMB1; PSMA2; PSMB7; PSMB5; PSMA3; PSMC1; PSMA4; PSMB6; PSMA7; PSMD8; PSMC4
R-HSA-69615	G1/S DNA Damage Checkpoints	3.21	1.18e-04	9.69e-04	13/52	PSMD4; RPS27A; PSMB1; PSMA2; PSMB7; PSMB5; PSMA3; PSMC1; PSMA4; PSMB6; PSMA7; PSMD8; PSMC4
R-HSA-1234176	Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha	3.21	1.18e-04	9.69e-04	13/52	PSMD4; RPS27A; PSMB1; PSMA2; PSMB7; PSMB5; PSMA3; PSMC1; PSMA4; PSMB6; PSMA7; PSMD8; PSMC4
R-HSA-174084	Autodegradation of Cdh1 by Cdh1:APC/C	3.21	1.18e-04	9.69e-04	13/52	PSMD4; RPS27A; PSMB1; PSMA2; PSMB7; PSMB5; PSMA3; PSMC1; PSMA4; PSMB6; PSMA7; PSMD8; PSMC4
R-HSA-5632684	Hedgehog 'on' state	3.21	1.18e-04	9.69e-04	13/52	PSMD4; RPS27A; PSMB1; PSMA2; PSMB7; PSMB5; PSMA3; PSMC1; PSMA4; PSMB6; PSMA7; PSMD8; PSMC4
R-HSA-975956	Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)	3.21	5.04e-07	2.00e-05	22/88	RPS7; RPS27A; RPSA; RPL9; RPL37; RPS10; RPS12; RPL10; RPS6; RPL41; RPS29; RPS27L; RPS17; RPS2; RPL13; RPL23A; RPL19; RPL27; RPS19; RPL13A; RPS5
R-HSA-418555	G alpha (s) signalling events	3.21	8.63e-03	4.32e-02	6/24	REEP1; GNG3; GNG2; GNAS; GNG8; PTH2
R-HSA-5607764	CLEC7A (Dectin-1) signaling	3.21	3.52e-05	4.73e-04	15/60	PSMD4; CALM2; RPS27A; PSMB1; PSMA2; PSMB7; PSMB5; PSMA3; PSMC1; PSMA4; PSMB6; PSMA7; PSMD8; PSMC4; CALM3
R-HSA-9010553	Regulation of expression of SLITs and ROBOs	3.18	5.61e-11	8.04e-09	37/149	RBM8A; PSMD4; RPS7; RPS27A; RPSA; ROBO2; RPL9; RPL37; RPS10; RPS12; PSMB1; PSMA2; RPL10; RPS6; PSMB7; RPL41; PSMB5; RPS29; PSMA3; PSMC1; RPS27L; PSMA4; RPS17; RPS2; RPL13; PSMB6; RPL23A; RPL19; RPL27; EIF4A3; PSMA7; PSMD8; PSMC4; RPS19; RPL13A; RPS5
R-HSA-983705	Signaling by the B Cell Receptor (BCR)	3.16	2.37e-05	3.47e-04	16/65	PSMD4; CALM2; RPS27A; PSMB1; PSMA2; PPIA; PSMB7; PSMB5; PSMA3; PSMC1; PSMA4; PSMB6; PSMA7; PSMD8; PSMC4; CALM3
R-HSA-69202	Cyclin E associated events during G1/S transition	3.15	7.96e-05	7.53e-04	14/57	PSMD4; RPS27A; PSMB1; PSMA2; PSMB7; CDK4; PSMB5; PSMA3; PSMC1; PSMA4; PSMB6; PSMA7; PSMD8; PSMC4
R-HSA-69656	Cyclin A:Cdk2-associated events at S phase entry	3.15	7.96e-05	7.53e-04	14/57	PSMD4; RPS27A; PSMB1; PSMA2; PSMB7; CDK4; PSMB5; PSMA3; PSMC1; PSMA4; PSMB6; PSMA7; PSMD8; PSMC4
R-HSA-174143	APC/C-mediated degradation of cell cycle proteins	3.15	7.96e-05	7.53e-04	14/57	PSMD4; RPS27A; PTTG1; PSMB1; PSMA2; PSMB7; PSMB5; PSMA3; PSMC1; PSMA4; PSMB6; PSMA7; PSMD8; PSMC4
R-HSA-453276	Regulation of mitotic cell cycle	3.15	7.96e-05	7.53e-04	14/57	PSMD4; RPS27A; PTTG1; PSMB1; PSMA2; PSMB7; PSMB5; PSMA3; PSMC1; PSMA4; PSMB6; PSMA7; PSMD8; PSMC4
R-HSA-2871837	FCERI mediated NF-kB activation	3.15	1.46e-04	1.14e-03	13/53	PSMD4; RPS27A; PSMB1; PSMA2; PSMB7; PSMB5; PSMA3; PSMC1; PSMA4; PSMB6; PSMA7; PSMD8; PSMC4
R-HSA-69017	CDK-mediated phosphorylation and removal of Cdc6	3.15	1.46e-04	1.14e-03	13/53	PSMD4; RPS27A; PSMB1; PSMA2; PSMB7; PSMB5; PSMA3; PSMC1; PSMA4; PSMB6; PSMA7; PSMD8; PSMC4
R-HSA-202424	Downstream TCR signaling	3.15	1.46e-04	1.14e-03	13/53	PSMD4; RPS27A; PSMB1; PSMA2; PSMB7; PSMB5; PSMA3; PSMC1; PSMA4; PSMB6; PSMA7; PSMD8; PSMC4
R-HSA-2408522	Selenoamino acid metabolism	3.11	2.78e-07	1.33e-05	24/99	RPS7; RPS27A; RPSA; RPL9; RPL37; EEF1E1; RPS10; RPS12; AIMP2; RPL10; RPS6; RPL41; RPS29; RPS27L; RPS17; RPS2; RPL13; RPL23A; RPL19; RPL27; RPS19; RPL13A; RPS5
R-HSA-72689	Formation of a pool of free 40S subunits	3.10	5.11e-07	2.00e-05	23/95	EIF3I; RPS7; RPS27A; RPSA; RPL9; RPL37; RPS10; RPS12; RPL10; RPS6; RPL41; RPS29; RPS27L; RPS17; RPS2; RPL13; RPL23A; RPL19; RPL27; RPS19; RPL13A; RPS5
R-HSA-72766	Translation	3.09	0.00e+00	0.00e+00	62/257	EIF3I; MRPL37; MRPL9; RPS7; RPS27A; MRPS9; RPSA; MRPS22; MRPL47; RPL9; MRPS18C; PPA2; RPL37; MRPS30; MRPL22; EEF1E1; MRPS18B; RPS10; MRPS10; MRPL2; MRPS18A; EEF1A1; RPS12; AIMP2; MRPL32; RPL10; MRPL15; RPS6; MRPL50; MRPS2; TRMT112; MRPL21; SPCS2; MRPL51; RPL41; MRPL42; RPS29; SRP14; RPS27L; RPS17; MRPL46; MRPS11; MRPS34; RPS2; RPL13; EIF4A1; RPL23A; RPL19; RPL27; MRPL27; ICT1; MRPS7; MRPL12; MRPS26; EEF2; FARSA; GADD45GIP1; RPS19; RPL13A; RPS5; MRPL39
R-HSA-174184	Cdc20:Phospho-APC/C mediated degradation of Cyclin A	3.09	1.79e-04	1.35e-03	13/54	PSMD4; RPS27A; PSMB1; PSMA2; PSMB7; PSMB5; PSMA3; PSMC1; PSMA4; PSMB6; PSMA7; PSMD8; PSMC4
R-HSA-179419	APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint	3.09	1.79e-04	1.35e-03	13/54	PSMD4; RPS27A; PSMB1; PSMA2; PSMB7; PSMB5; PSMA3; PSMC1; PSMA4; PSMB6; PSMA7; PSMD8; PSMC4
R-HSA-8878159	Transcriptional regulation by RUNX3	3.04	1.19e-04	9.69e-04	14/59	PSMD4; RPS27A; PSMB1; PSMA2; PSMB7; PSMB5; PSMA3; SNW1; PSMC1; PSMA4; PSMB6; PSMA7; PSMD8; PSMC4
R-HSA-9020702	Interleukin-1 signaling	3.04	1.19e-04	9.69e-04	14/59	PSMD4; RPS27A; PSMB1; PSMA2; PSMB7; PSMB5; PSMA3; PSMC1; PSMA4; PSMB6; PSMA7; PSMD8; PSMC4; APP
R-HSA-8948751	Regulation of PTEN stability and activity	3.03	2.18e-04	1.59e-03	13/55	PSMD4; RPS27A; PSMB1; PSMA2; PSMB7; PSMB5; PSMA3; PSMC1; PSMA4; PSMB6; PSMA7; PSMD8; PSMC4
R-HSA-5619115	Disorders of transmembrane transporters	3.03	2.18e-04	1.59e-03	13/55	PSMD4; RPS27A; PSMB1; PSMA2; PSMB7; PSMB5; PSMA3; PSMC1; PSMA4; PSMB6; PSMA7; PSMD8; PSMC4
R-HSA-8939236	RUNX1 regulates transcription of genes involved in differentiation of HSCs	2.99	1.45e-04	1.14e-03	14/60	PSMD4; H3F3A; RPS27A; PSMB1; PSMA2; PSMB7; PSMB5; PSMA3; PSMC1; PSMA4; PSMB6; PSMA7; PSMD8; PSMC4
R-HSA-6790901	rRNA modification in the nucleus and cytosol	2.98	1.34e-03	7.91e-03	10/43	RPS7; WDR43; RRP9; WBSCR22; DCAF13; RPS6; TRMT112; KRR1; RPS2; DDX52
R-HSA-382556	ABC-family proteins mediated transport	2.98	2.65e-04	1.87e-03	13/56	PSMD4; RPS27A; PSMB1; PSMA2; PSMB7; PSMB5; PSMA3; PSMC1; PSMA4; PSMB6; PSMA7; PSMD8; PSMC4
R-HSA-351202	Metabolism of polyamines	2.98	2.65e-04	1.87e-03	13/56	PSMD4; PSMB1; PSMA2; SAT1; PSMB7; PSMB5; PSMA3; PSMC1; PSMA4; PSMB6; PSMA7; PSMD8; PSMC4
R-HSA-176408	Regulation of APC/C activators between G1/S and early anaphase	2.98	2.65e-04	1.87e-03	13/56	PSMD4; RPS27A; PSMB1; PSMA2; PSMB7; PSMB5; PSMA3; PSMC1; PSMA4; PSMB6; PSMA7; PSMD8; PSMC4
R-HSA-5610787	Hedgehog 'off' state	2.97	5.26e-05	5.66e-04	16/69	PSMD4; RPS27A; TUBB2B; PSMB1; PSMA2; PSMB7; TUBA1A; PSMB5; PSMA3; PSMC1; PSMA4; PSMB6; GNAS; PSMA7; PSMD8; PSMC4
R-HSA-1799339	SRP-dependent cotranslational protein targeting to membrane	2.96	7.41e-07	2.77e-05	24/104	RPS7; RPS27A; RPSA; RPL9; RPL37; RPS10; RPS12; RPL10; RPS6; SPCS2; RPL41; RPS29; SRP14; RPS27L; RPS17; RPS2; RPL13; RPL23A; RPL19; RPL27; RPS19; RPL13A; RPS5
R-HSA-156827	L13a-mediated translational silencing of Ceruloplasmin expression	2.93	8.94e-07	2.96e-05	24/105	EIF3I; RPS7; RPS27A; RPSA; RPL9; RPL37; RPS10; RPS12; RPL10; RPS6; RPL41; RPS29; RPS27L; RPS17; RPS2; RPL13; EIF4A1; RPL23A; RPL19; RPL27; RPS19; RPL13A; RPS5
R-HSA-927802	Nonsense-Mediated Decay (NMD)	2.93	8.94e-07	2.96e-05	24/105	RBM8A; RPS7; RPS27A; RPSA; RPL9; RPL37; RPS10; RPS12; RPL10; RPS6; RPL41; RPS29; RPS27L; RPS17; RPS2; RPL13; RPL23A; RPL19; RPL27; EIF4A3; RPS19; RPL13A; RPS5
R-HSA-975957	Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)	2.93	8.94e-07	2.96e-05	24/105	RBM8A; RPS7; RPS27A; RPSA; RPL9; RPL37; RPS10; RPS12; RPL10; RPS6; RPL41; RPS29; RPS27L; RPS17; RPS2; RPL13; RPL23A; RPL19; RPL27; EIF4A3; RPS19; RPL13A; RPS5
R-HSA-5576891	Cardiac conduction	2.93	4.53e-03	2.38e-02	8/35	ATP1B1; CALM2; SCN3A; SRI; FXYD6; ATP2B1; FXYD7; CALM3
R-HSA-1234174	Regulation of Hypoxia-inducible Factor (HIF) by oxygen	2.92	3.19e-04	2.16e-03	13/57	PSMD4; RPS27A; PSMB1; PSMA2; PSMB7; PSMB5; PSMA3; PSMC1; PSMA4; PSMB6; PSMA7; PSMD8; PSMC4
R-HSA-2262749	Cellular response to hypoxia	2.92	3.19e-04	2.16e-03	13/57	PSMD4; RPS27A; PSMB1; PSMA2; PSMB7; PSMB5; PSMA3; PSMC1; PSMA4; PSMB6; PSMA7; PSMD8; PSMC4
R-HSA-72706	GTP hydrolysis and joining of the 60S ribosomal subunit	2.90	1.08e-06	3.43e-05	24/106	EIF3I; RPS7; RPS27A; RPSA; RPL9; RPL37; RPS10; RPS12; RPL10; RPS6; RPL41; RPS29; RPS27L; RPS17; RPS2; RPL13; EIF4A1; RPL23A; RPL19; RPL27; RPS19; RPL13A; RPS5
R-HSA-4086400	PCP/CE pathway	2.85	2.52e-04	1.82e-03	14/63	PSMD4; RPS27A; PSMB1; PSMA2; PSMB7; PSMB5; PSMA3; DAAM1; PSMC1; PSMA4; PSMB6; PSMA7; PSMD8; PSMC4
R-HSA-3858494	Beta-catenin independent WNT signaling	2.83	2.17e-05	3.42e-04	19/86	PSMD4; CALM2; RPS27A; PSMB1; PSMA2; PSMB7; GNG3; PSMB5; GNG2; PSMA3; DAAM1; PSMC1; PSMA4; PSMB6; PSMA7; PSMD8; PSMC4; CALM3; GNG8
R-HSA-6791226	Major pathway of rRNA processing in the nucleolus and cytosol	2.83	1.02e-08	7.95e-07	34/154	RPS7; WDR43; RPS27A; RPSA; EXOSC7; RRP9; RPL9; RPL37; RPS10; RPS12; WBSCR22; RPL10; DCAF13; EXOSC4; RPS6; DDX21; EXOSC1; RPL41; KRR1; EXOSC8; RPS29; RPS27L; RPS17; RPS2; NOB1; RPL13; RPL23A; DDX52; RPL19; RPL27; RPS19; RPL13A; RPS5
R-HSA-69052	Switching of origins to a post-replicative state	2.83	4.58e-04	2.99e-03	13/59	PSMD4; RPS27A; PSMB1; PSMA2; PSMB7; PSMB5; PSMA3; PSMC1; PSMA4; PSMB6; PSMA7; PSMD8; PSMC4
R-HSA-376176	Signaling by ROBO receptors	2.81	9.28e-10	1.14e-07	39/178	RBM8A; PSMD4; RPS7; RPS27A; SRGAP3; RPSA; ROBO2; RPL9; RPL37; RPS10; RPS12; PSMB1; PSMA2; RPL10; RPS6; PSMB7; RPL41; PSMB5; RPS29; PSMA3; PSMC1; RPS27L; PSMA4; RPS17; RPS2; RPL13; PSMB6; RPL23A; RPL19; RPL27; EIF4A3; DCC; PSMA7; PSMD8; PSMC4; RPS19; RPL13A; RPS5
R-HSA-8868773	rRNA processing in the nucleus and cytosol	2.80	7.80e-09	7.45e-07	35/160	RPS7; WDR43; RPS27A; RPSA; EXOSC7; RRP9; RPL9; RPL37; RPS10; RPS12; WBSCR22; RPL10; DCAF13; EXOSC4; RPS6; TRMT112; DDX21; EXOSC1; RPL41; KRR1; EXOSC8; RPS29; RPS27L; RPS17; RPS2; NOB1; RPL13; RPL23A; DDX52; RPL19; RPL27; RPS19; RPL13A; RPS5
R-HSA-5689603	UCH proteinases	2.79	1.97e-04	1.46e-03	15/69	PSMD4; RPS27A; UCHL1; PSMB1; PSMA2; PSMB7; PSMB5; PSMA3; PSMC1; PSMA4; PSMB6; PSMA7; ADRM1; PSMD8; PSMC4
R-HSA-5687128	MAPK6/MAPK4 signaling	2.76	3.57e-04	2.40e-03	14/65	PSMD4; RPS27A; PSMB1; PSMA2; HSPB1; PSMB7; PSMB5; PSMA3; PSMC1; PSMA4; PSMB6; PSMA7; PSMD8; PSMC4
R-HSA-72312	rRNA processing	2.74	1.55e-08	1.03e-06	35/164	RPS7; WDR43; RPS27A; RPSA; EXOSC7; RRP9; RPL9; RPL37; RPS10; RPS12; WBSCR22; RPL10; DCAF13; EXOSC4; RPS6; TRMT112; DDX21; EXOSC1; RPL41; KRR1; EXOSC8; RPS29; RPS27L; RPS17; RPS2; NOB1; RPL13; RPL23A; DDX52; RPL19; RPL27; RPS19; RPL13A; RPS5
R-HSA-202403	TCR signaling	2.73	6.44e-04	4.05e-03	13/61	PSMD4; RPS27A; PSMB1; PSMA2; PSMB7; PSMB5; PSMA3; PSMC1; PSMA4; PSMB6; PSMA7; PSMD8; PSMC4
R-HSA-72613	Eukaryotic Translation Initiation	2.72	3.64e-06	1.01e-04	24/113	EIF3I; RPS7; RPS27A; RPSA; RPL9; RPL37; RPS10; RPS12; RPL10; RPS6; RPL41; RPS29; RPS27L; RPS17; RPS2; RPL13; EIF4A1; RPL23A; RPL19; RPL27; RPS19; RPL13A; RPS5
R-HSA-72737	Cap-dependent Translation Initiation	2.72	3.64e-06	1.01e-04	24/113	EIF3I; RPS7; RPS27A; RPSA; RPL9; RPL37; RPS10; RPS12; RPL10; RPS6; RPL41; RPS29; RPS27L; RPS17; RPS2; RPL13; EIF4A1; RPL23A; RPL19; RPL27; RPS19; RPL13A; RPS5
R-HSA-8878166	Transcriptional regulation by RUNX2	2.72	4.21e-04	2.79e-03	14/66	PSMD4; RPS27A; PSMB1; PSMA2; PSMB7; CDK4; PSMB5; PSMA3; PSMC1; PSMA4; PSMB6; PSMA7; PSMD8; PSMC4
R-HSA-446652	Interleukin-1 family signaling	2.72	4.21e-04	2.79e-03	14/66	PSMD4; RPS27A; PSMB1; PSMA2; PSMB7; PSMB5; PSMA3; PSMC1; PSMA4; PSMB6; PSMA7; PSMD8; PSMC4; APP
R-HSA-5621481	C-type lectin receptors (CLRs)	2.71	2.76e-04	1.93e-03	15/71	PSMD4; CALM2; RPS27A; PSMB1; PSMA2; PSMB7; PSMB5; PSMA3; PSMC1; PSMA4; PSMB6; PSMA7; PSMD8; PSMC4; CALM3
R-HSA-195253	Degradation of beta-catenin by the destruction complex	2.69	7.59e-04	4.70e-03	13/62	PSMD4; RPS27A; PSMB1; PSMA2; PSMB7; PSMB5; PSMA3; PSMC1; PSMA4; PSMB6; PSMA7; PSMD8; PSMC4
R-HSA-373760	L1CAM interactions	2.64	5.82e-04	3.70e-03	14/68	NFASC; SCN3A; ALCAM; GAP43; ANK2; TUBB2B; CD24; DCX; DPYSL2; SPTAN1; NCAM1; ANK3; TUBA1A; ACTG1
R-HSA-168273	Influenza Viral RNA Transcription and Replication	2.61	1.24e-05	2.37e-04	23/113	RPS7; RPS27A; RPSA; RPL9; RPL37; RPS10; RPS12; RPL10; RPS6; RPL41; RPS29; RPS27L; RPS17; RPS2; RPL13; RPL23A; RPL19; RPL27; RAE1; RPS19; RPL13A; RPS5
R-HSA-2454202	Fc epsilon receptor (FCERI) signaling	2.60	2.90e-04	2.01e-03	16/79	PSMD4; CALM2; RPS27A; MAPK10; PSMB1; PSMA2; PSMB7; PSMB5; PSMA3; PSMC1; PSMA4; PSMB6; PSMA7; PSMD8; PSMC4; CALM3
R-HSA-611105	Respiratory electron transport	2.56	9.36e-05	8.53e-04	19/95	SDHB; NDUFS2; COX5B; NDUFB5; NDUFS6; NDUFS4; COX7C; NDUFA4; COX6C; CYC1; NDUFS3; COX8A; TMEM126B; SDHD; NDUFA9; NDUFA12; COX6A1; NDUFB10; UQCRFS1
R-HSA-168255	Influenza Life Cycle	2.54	1.27e-05	2.37e-04	24/121	RPS7; RPS27A; RPSA; RPL9; RPL37; RPS10; RPS12; RPL10; RPS6; RPL41; RAN; RPS29; RPS27L; RPS17; RPS2; RPL13; RPL23A; RPL19; RPL27; RAE1; RPS19; RPL13A; RPS5
R-HSA-69206	G1/S Transition	2.53	9.18e-04	5.64e-03	14/71	PSMD4; RPS27A; PSMB1; PSMA2; PSMB7; CDK4; PSMB5; PSMA3; PSMC1; PSMA4; PSMB6; PSMA7; PSMD8; PSMC4
R-HSA-69239	Synthesis of DNA	2.53	1.41e-03	8.13e-03	13/66	PSMD4; RPS27A; PSMB1; PSMA2; PSMB7; PSMB5; PSMA3; PSMC1; PSMA4; PSMB6; PSMA7; PSMD8; PSMC4
R-HSA-5358351	Signaling by Hedgehog	2.50	4.52e-04	2.97e-03	16/82	PSMD4; RPS27A; TUBB2B; PSMB1; PSMA2; PSMB7; TUBA1A; PSMB5; PSMA3; PSMC1; PSMA4; PSMB6; GNAS; PSMA7; PSMD8; PSMC4
R-HSA-163200	Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.	2.47	4.64e-05	5.34e-04	22/114	SDHB; NDUFS2; COX5B; NDUFB5; NDUFS6; NDUFS4; COX7C; NDUFA4; COX6C; CYC1; NDUFS3; COX8A; TMEM126B; SDHD; NDUFA9; ATP5B; NDUFA12; COX6A1; NDUFB10; ATP5E; UQCRFS1; ATP5O
R-HSA-5673001	RAF/MAP kinase cascade	2.47	7.12e-05	7.21e-04	21/109	PSMD4; CALM2; RPS27A; PSMB1; PSMA2; NEFL; NRG1; PSMB7; SPTAN1; NCAM1; PSMB5; PSMA3; PSMC1; PSMA4; PSMB6; PHB; ACTG1; PSMA7; PSMD8; PSMC4; CALM3
R-HSA-109581	Apoptosis	2.46	1.67e-04	1.28e-03	19/99	PSMD4; RPS27A; SATB1; CASP3; PSMB1; PSMA2; FNTA; YWHAZ; PSMB7; SPTAN1; PSMB5; PSMA3; PSMC1; PSMA4; PSMB6; DCC; PSMA7; PSMD8; PSMC4
R-HSA-5357801	Programmed Cell Death	2.46	1.67e-04	1.28e-03	19/99	PSMD4; RPS27A; SATB1; CASP3; PSMB1; PSMA2; FNTA; YWHAZ; PSMB7; SPTAN1; PSMB5; PSMA3; PSMC1; PSMA4; PSMB6; DCC; PSMA7; PSMD8; PSMC4
R-HSA-5684996	MAPK1/MAPK3 signaling	2.45	8.18e-05	7.66e-04	21/110	PSMD4; CALM2; RPS27A; PSMB1; PSMA2; NEFL; NRG1; PSMB7; SPTAN1; NCAM1; PSMB5; PSMA3; PSMC1; PSMA4; PSMB6; PHB; ACTG1; PSMA7; PSMD8; PSMC4; CALM3
R-HSA-391251	Protein folding	2.43	4.41e-03	2.33e-02	11/58	PFDN2; CCT5; PFDN1; TUBB2B; TBCC; CCT6A; GNG3; TUBA1A; GNG2; PFDN4; GNG8
R-HSA-390466	Chaperonin-mediated protein folding	2.42	6.79e-03	3.42e-02	10/53	PFDN2; CCT5; PFDN1; TUBB2B; CCT6A; GNG3; TUBA1A; GNG2; PFDN4; GNG8
R-HSA-69306	DNA Replication	2.42	2.15e-03	1.19e-02	13/69	PSMD4; RPS27A; PSMB1; PSMA2; PSMB7; PSMB5; PSMA3; PSMC1; PSMA4; PSMB6; PSMA7; PSMD8; PSMC4
R-HSA-168254	Influenza Infection	2.40	3.42e-05	4.73e-04	24/128	RPS7; RPS27A; RPSA; RPL9; RPL37; RPS10; RPS12; RPL10; RPS6; RPL41; RAN; RPS29; RPS27L; RPS17; RPS2; RPL13; RPL23A; RPL19; RPL27; RAE1; RPS19; RPL13A; RPS5
R-HSA-157118	Signaling by NOTCH	2.37	1.88e-04	1.41e-03	20/108	YBX1; PSMD4; PBX1; H3F3A; RPS27A; PSMB1; PSMA2; YWHAZ; PSMB7; PSMB5; PSMA3; SNW1; PSMC1; PSMA4; PSMB6; PSMA7; SIRT6; PSMD8; PSMC4; MFNG
R-HSA-453279	Mitotic G1-G1/S phases	2.36	1.84e-03	1.03e-02	14/76	PSMD4; RPS27A; PSMB1; PSMA2; PSMB7; CDK4; PSMB5; PSMA3; PSMC1; PSMA4; PSMB6; PSMA7; PSMD8; PSMC4
R-HSA-71291	Metabolism of amino acids and derivatives	2.33	3.34e-07	1.52e-05	38/209	PSMD4; RPS7; RPS27A; RPSA; RPL9; RPL37; EEF1E1; RPS10; SERINC1; RPS12; PSMB1; AIMP2; PSMA2; SAT1; RPL10; RPS6; PSMB7; RPL41; PSMB5; RPS29; PSMA3; PSMC1; RPS27L; PSMA4; RPS17; RPS2; RPL13; PSMB6; RPL23A; RPL19; RPL27; PSMA7; PSMD8; PSMC4; RPS19; RPL13A; RPS5
R-HSA-381119	Unfolded Protein Response (UPR)	2.31	6.57e-03	3.33e-02	11/61	DCTN1; EXOSC7; SEC62; EXOSC4; YIF1A; EXOSC1; DDIT3; EXOSC8; MYDGF; ASNA1; ATF4
R-HSA-69481	G2/M Checkpoints	2.30	2.37e-03	1.29e-02	14/78	PSMD4; RPS27A; PSMB1; PSMA2; YWHAZ; PSMB7; PSMB5; PSMA3; PSMC1; PSMA4; PSMB6; PSMA7; PSMD8; PSMC4
R-HSA-162909	Host Interactions of HIV factors	2.23	1.67e-03	9.52e-03	16/92	PSMD4; RPS27A; PSMB1; PSMA2; PPIA; PSMB7; RAN; PSMB5; PSMA3; PSMC1; PSMA4; PSMB6; RAE1; PSMA7; PSMD8; PSMC4
R-HSA-422475	Axon guidance	2.23	1.26e-09	1.36e-07	57/328	RBM8A; PSMD4; NFASC; RPS7; RPS27A; SCN3A; SRGAP3; RPSA; ROBO2; ALCAM; GAP43; RPL9; ANK2; RPL37; RGMB; DPYSL3; TUBB2B; RPS10; CD24; RPS12; PSMB1; PSMA2; DCX; RPL10; DPYSL2; RPS6; PSMB7; SPTAN1; NCAM1; ANK3; TUBA1A; RPL41; MYL6; PSMB5; RPS29; PSMA3; PSMC1; RPS27L; PSMA4; RPS17; RPS2; RPL13; PSMB6; RPL23A; RPL19; RPL27; EIF4A3; ACTG1; DCC; PSMA7; PSMD8; PSMC4; RPS19; RPL13A; RPS5; COL6A1
R-HSA-2467813	Separation of Sister Chromatids	2.14	1.07e-03	6.51e-03	19/114	NUDC; PSMD4; PMF1; RPS27A; PTTG1; TUBB2B; PSMB1; PSMA2; PSMB7; TUBA1A; PSMB5; PSMA3; PSMC1; RPS27L; PSMA4; PSMB6; PSMA7; PSMD8; PSMC4
R-HSA-5683057	MAPK family signaling cascades	2.12	4.86e-04	3.15e-03	22/133	PSMD4; CALM2; RPS27A; PSMB1; PSMA2; HSPB1; NEFL; NRG1; PSMB7; SPTAN1; NCAM1; PSMB5; PSMA3; PSMC1; PSMA4; PSMB6; PHB; ACTG1; PSMA7; PSMD8; PSMC4; CALM3
R-HSA-1428517	The citric acid (TCA) cycle and respiratory electron transport	2.06	5.49e-04	3.53e-03	23/143	SDHB; NDUFS2; COX5B; NDUFB5; NDUFS6; NDUFS4; COX7C; NDUFA4; COX6C; CYC1; NDUFS3; COX8A; TMEM126B; SDHD; NDUFA9; ATP5B; NDUFA12; COX6A1; NDUFB10; IDH3B; ATP5E; UQCRFS1; ATP5O
R-HSA-2555396	Mitotic Metaphase and Anaphase	2.01	2.22e-03	1.21e-02	19/121	NUDC; PSMD4; PMF1; RPS27A; PTTG1; TUBB2B; PSMB1; PSMA2; PSMB7; TUBA1A; PSMB5; PSMA3; PSMC1; RPS27L; PSMA4; PSMB6; PSMA7; PSMD8; PSMC4
R-HSA-68882	Mitotic Anaphase	2.01	2.22e-03	1.21e-02	19/121	NUDC; PSMD4; PMF1; RPS27A; PTTG1; TUBB2B; PSMB1; PSMA2; PSMB7; TUBA1A; PSMB5; PSMA3; PSMC1; RPS27L; PSMA4; PSMB6; PSMA7; PSMD8; PSMC4

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Factor 2 : 217 significant Reactome pathways

GeneSet	description	enrichRatio	pValue	FDR	GeneRatio	geneSymbols
R-HSA-156902	Peptide chain elongation	9.54	0.00e+00	0.00e+00	77/84	RPL22; RPL11; RPS8; RPL5; RPS27; RPS7; RPS27A; RPL31; RPL37A; RPL32; RPL15; RPSA; RPL14; RPL29; RPL24; RPL35A; RPL9; RPL34; RPS3A; RPL37; RPS23; RPS14; RPS18; RPS10; RPL10A; RPS12; RPS4X; RPL36A; RPL39; RPL10; RPS20; RPL7; RPL30; RPL8; RPS6; RPL35; RPL12; RPL7A; RPLP2; RPL27A; RPS13; RPS3; RPS25; RPS24; RPL41; RPL6; RPLP0; RPL21; RPS29; RPL4; RPLP1; RPS17; RPS2; RPS15A; RPL13; RPL26; RPL23A; RPL23; RPL19; RPL27; RPL38; RPS21; RPS15; EEF2; RPL36; RPS28; RPL18A; UBA52; RPS16; RPS19; RPL18; RPL13A; RPS11; RPS9; RPL28; RPS5; RPL3
R-HSA-192823	Viral mRNA Translation	9.53	0.00e+00	0.00e+00	76/83	RPL22; RPL11; RPS8; RPL5; RPS27; RPS7; RPS27A; RPL31; RPL37A; RPL32; RPL15; RPSA; RPL14; RPL29; RPL24; RPL35A; RPL9; RPL34; RPS3A; RPL37; RPS23; RPS14; RPS18; RPS10; RPL10A; RPS12; RPS4X; RPL36A; RPL39; RPL10; RPS20; RPL7; RPL30; RPL8; RPS6; RPL35; RPL12; RPL7A; RPLP2; RPL27A; RPS13; RPS3; RPS25; RPS24; RPL41; RPL6; RPLP0; RPL21; RPS29; RPL4; RPLP1; RPS17; RPS2; RPS15A; RPL13; RPL26; RPL23A; RPL23; RPL19; RPL27; RPL38; RPS21; RPS15; RPL36; RPS28; RPL18A; UBA52; RPS16; RPS19; RPL18; RPL13A; RPS11; RPS9; RPL28; RPS5; RPL3
R-HSA-156842	Eukaryotic Translation Elongation	9.32	0.00e+00	0.00e+00	77/86	RPL22; RPL11; RPS8; RPL5; RPS27; RPS7; RPS27A; RPL31; RPL37A; RPL32; RPL15; RPSA; RPL14; RPL29; RPL24; RPL35A; RPL9; RPL34; RPS3A; RPL37; RPS23; RPS14; RPS18; RPS10; RPL10A; RPS12; RPS4X; RPL36A; RPL39; RPL10; RPS20; RPL7; RPL30; RPL8; RPS6; RPL35; RPL12; RPL7A; RPLP2; RPL27A; RPS13; RPS3; RPS25; RPS24; RPL41; RPL6; RPLP0; RPL21; RPS29; RPL4; RPLP1; RPS17; RPS2; RPS15A; RPL13; RPL26; RPL23A; RPL23; RPL19; RPL27; RPL38; RPS21; RPS15; EEF2; RPL36; RPS28; RPL18A; UBA52; RPS16; RPS19; RPL18; RPL13A; RPS11; RPS9; RPL28; RPS5; RPL3
R-HSA-2408557	Selenocysteine synthesis	9.31	0.00e+00	0.00e+00	76/85	RPL22; RPL11; RPS8; RPL5; RPS27; RPS7; RPS27A; RPL31; RPL37A; RPL32; RPL15; RPSA; RPL14; RPL29; RPL24; RPL35A; RPL9; RPL34; RPS3A; RPL37; RPS23; RPS14; RPS18; RPS10; RPL10A; RPS12; RPS4X; RPL36A; RPL39; RPL10; RPS20; RPL7; RPL30; RPL8; RPS6; RPL35; RPL12; RPL7A; RPLP2; RPL27A; RPS13; RPS3; RPS25; RPS24; RPL41; RPL6; RPLP0; RPL21; RPS29; RPL4; RPLP1; RPS17; RPS2; RPS15A; RPL13; RPL26; RPL23A; RPL23; RPL19; RPL27; RPL38; RPS21; RPS15; RPL36; RPS28; RPL18A; UBA52; RPS16; RPS19; RPL18; RPL13A; RPS11; RPS9; RPL28; RPS5; RPL3
R-HSA-72764	Eukaryotic Translation Termination	9.20	0.00e+00	0.00e+00	76/86	RPL22; RPL11; RPS8; RPL5; RPS27; RPS7; RPS27A; RPL31; RPL37A; RPL32; RPL15; RPSA; RPL14; RPL29; RPL24; RPL35A; RPL9; RPL34; RPS3A; RPL37; RPS23; RPS14; RPS18; RPS10; RPL10A; RPS12; RPS4X; RPL36A; RPL39; RPL10; RPS20; RPL7; RPL30; RPL8; RPS6; RPL35; RPL12; RPL7A; RPLP2; RPL27A; RPS13; RPS3; RPS25; RPS24; RPL41; RPL6; RPLP0; RPL21; RPS29; RPL4; RPLP1; RPS17; RPS2; RPS15A; RPL13; RPL26; RPL23A; RPL23; RPL19; RPL27; RPL38; RPS21; RPS15; RPL36; RPS28; RPL18A; UBA52; RPS16; RPS19; RPL18; RPL13A; RPS11; RPS9; RPL28; RPS5; RPL3
R-HSA-975956	Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)	9.11	0.00e+00	0.00e+00	77/88	RPL22; RPL11; RPS8; RPL5; RPS27; RPS7; RPS27A; RPL31; RPL37A; RPL32; RPL15; RPSA; RPL14; RPL29; RPL24; RPL35A; RPL9; RPL34; RPS3A; RPL37; RPS23; RPS14; RPS18; RPS10; RPL10A; RPS12; RPS4X; RPL36A; RPL39; RPL10; RPS20; RPL7; RPL30; PABPC1; RPL8; RPS6; RPL35; RPL12; RPL7A; RPLP2; RPL27A; RPS13; RPS3; RPS25; RPS24; RPL41; RPL6; RPLP0; RPL21; RPS29; RPL4; RPLP1; RPS17; RPS2; RPS15A; RPL13; RPL26; RPL23A; RPL23; RPL19; RPL27; RPL38; RPS21; RPS15; RPL36; RPS28; RPL18A; UBA52; RPS16; RPS19; RPL18; RPL13A; RPS11; RPS9; RPL28; RPS5; RPL3
R-HSA-72689	Formation of a pool of free 40S subunits	8.33	0.00e+00	0.00e+00	76/95	RPL22; RPL11; RPS8; RPL5; RPS27; RPS7; RPS27A; RPL31; RPL37A; RPL32; RPL15; RPSA; RPL14; RPL29; RPL24; RPL35A; RPL9; RPL34; RPS3A; RPL37; RPS23; RPS14; RPS18; RPS10; RPL10A; RPS12; RPS4X; RPL36A; RPL39; RPL10; RPS20; RPL7; RPL30; RPL8; RPS6; RPL35; RPL12; RPL7A; RPLP2; RPL27A; RPS13; RPS3; RPS25; RPS24; RPL41; RPL6; RPLP0; RPL21; RPS29; RPL4; RPLP1; RPS17; RPS2; RPS15A; RPL13; RPL26; RPL23A; RPL23; RPL19; RPL27; RPL38; RPS21; RPS15; RPL36; RPS28; RPL18A; UBA52; RPS16; RPS19; RPL18; RPL13A; RPS11; RPS9; RPL28; RPS5; RPL3
R-HSA-1799339	SRP-dependent cotranslational protein targeting to membrane	8.31	0.00e+00	0.00e+00	83/104	RPL22; DDOST; RPL11; RPS8; RPL5; RPS27; SRP9; RPS7; RPS27A; RPL31; RPL37A; RPL32; RPL15; RPSA; RPL14; RPL29; RPL24; RPL35A; RPL9; RPL34; RPS3A; RPL37; RPS23; RPS14; RPS18; RPS10; RPL10A; RPS12; RPS4X; RPL36A; RPL39; SSR4; RPL10; RPS20; RPL7; RPL30; RPL8; RPS6; RPL35; RPL12; RPL7A; RPLP2; RPL27A; RPS13; SPCS2; RPS3; RPS25; RPS24; RPL41; RPL6; RPLP0; RPL21; RPS29; SRP14; RPL4; RPLP1; RPS17; RPS2; RPS15A; RPL13; RPL26; RPL23A; RPL23; RPL19; RPL27; RPL38; SEC11C; RPN2; RPS21; RPS15; RPL36; RPS28; RPL18A; UBA52; RPS16; RPS19; RPL18; RPL13A; RPS11; RPS9; RPL28; RPS5; RPL3
R-HSA-5626467	RHO GTPases activate IQGAPs	8.10	9.52e-12	2.34e-10	14/18	CDC42; CALM2; TUBA4A; CTNNB1; TUBB2A; TUBB2B; ACTB; TUBB4B; TUBA1B; TUBA1A; CALM1; TUBB3; ACTG1; CALM3
R-HSA-2408522	Selenoamino acid metabolism	7.99	0.00e+00	0.00e+00	76/99	RPL22; RPL11; RPS8; RPL5; RPS27; RPS7; RPS27A; RPL31; RPL37A; RPL32; RPL15; RPSA; RPL14; RPL29; RPL24; RPL35A; RPL9; RPL34; RPS3A; RPL37; RPS23; RPS14; RPS18; RPS10; RPL10A; RPS12; RPS4X; RPL36A; RPL39; RPL10; RPS20; RPL7; RPL30; RPL8; RPS6; RPL35; RPL12; RPL7A; RPLP2; RPL27A; RPS13; RPS3; RPS25; RPS24; RPL41; RPL6; RPLP0; RPL21; RPS29; RPL4; RPLP1; RPS17; RPS2; RPS15A; RPL13; RPL26; RPL23A; RPL23; RPL19; RPL27; RPL38; RPS21; RPS15; RPL36; RPS28; RPL18A; UBA52; RPS16; RPS19; RPL18; RPL13A; RPS11; RPS9; RPL28; RPS5; RPL3
R-HSA-156827	L13a-mediated translational silencing of Ceruloplasmin expression	7.83	0.00e+00	0.00e+00	79/105	RPL22; RPL11; RPS8; RPL5; RPS27; RPS7; RPS27A; RPL31; RPL37A; RPL32; RPL15; RPSA; RPL14; RPL29; RPL24; EIF4A2; RPL35A; RPL9; RPL34; RPS3A; RPL37; RPS23; RPS14; RPS18; RPS10; RPL10A; RPS12; RPS4X; RPL36A; RPL39; RPL10; RPS20; RPL7; RPL30; PABPC1; RPL8; RPS6; RPL35; RPL12; RPL7A; RPLP2; RPL27A; RPS13; RPS3; RPS25; RPS24; RPL41; RPL6; RPLP0; RPL21; RPS29; RPL4; RPLP1; RPS17; RPS2; RPS15A; RPL13; EIF4A1; RPL26; RPL23A; RPL23; RPL19; RPL27; RPL38; RPS21; RPS15; RPL36; RPS28; RPL18A; UBA52; RPS16; RPS19; RPL18; RPL13A; RPS11; RPS9; RPL28; RPS5; RPL3
R-HSA-927802	Nonsense-Mediated Decay (NMD)	7.73	0.00e+00	0.00e+00	78/105	RPL22; RPL11; RPS8; RPL5; RPS27; RPS7; RPS27A; RPL31; RPL37A; RPL32; RPL15; RPSA; RPL14; RPL29; RPL24; RPL35A; RPL9; RPL34; RPS3A; RPL37; RPS23; RPS14; RPS18; RPS10; RPL10A; RPS12; RPS4X; RPL36A; RPL39; RPL10; RPS20; RPL7; RPL30; PABPC1; RPL8; RPS6; RPL35; RPL12; RPL7A; RPLP2; RPL27A; RPS13; RPS3; RPS25; RPS24; RPL41; RPL6; RPLP0; RPL21; RPS29; RPL4; RPLP1; RPS17; RPS2; RPS15A; RPL13; RPL26; RPL23A; RPL23; RPL19; RPL27; RPL38; EIF4A3; RPS21; RPS15; RPL36; RPS28; RPL18A; UBA52; RPS16; RPS19; RPL18; RPL13A; RPS11; RPS9; RPL28; RPS5; RPL3
R-HSA-975957	Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)	7.73	0.00e+00	0.00e+00	78/105	RPL22; RPL11; RPS8; RPL5; RPS27; RPS7; RPS27A; RPL31; RPL37A; RPL32; RPL15; RPSA; RPL14; RPL29; RPL24; RPL35A; RPL9; RPL34; RPS3A; RPL37; RPS23; RPS14; RPS18; RPS10; RPL10A; RPS12; RPS4X; RPL36A; RPL39; RPL10; RPS20; RPL7; RPL30; PABPC1; RPL8; RPS6; RPL35; RPL12; RPL7A; RPLP2; RPL27A; RPS13; RPS3; RPS25; RPS24; RPL41; RPL6; RPLP0; RPL21; RPS29; RPL4; RPLP1; RPS17; RPS2; RPS15A; RPL13; RPL26; RPL23A; RPL23; RPL19; RPL27; RPL38; EIF4A3; RPS21; RPS15; RPL36; RPS28; RPL18A; UBA52; RPS16; RPS19; RPL18; RPL13A; RPS11; RPS9; RPL28; RPS5; RPL3
R-HSA-72706	GTP hydrolysis and joining of the 60S ribosomal subunit	7.66	0.00e+00	0.00e+00	78/106	RPL22; RPL11; RPS8; RPL5; RPS27; RPS7; RPS27A; RPL31; RPL37A; RPL32; RPL15; RPSA; RPL14; RPL29; RPL24; EIF4A2; RPL35A; RPL9; RPL34; RPS3A; RPL37; RPS23; RPS14; RPS18; RPS10; RPL10A; RPS12; RPS4X; RPL36A; RPL39; RPL10; RPS20; RPL7; RPL30; RPL8; RPS6; RPL35; RPL12; RPL7A; RPLP2; RPL27A; RPS13; RPS3; RPS25; RPS24; RPL41; RPL6; RPLP0; RPL21; RPS29; RPL4; RPLP1; RPS17; RPS2; RPS15A; RPL13; EIF4A1; RPL26; RPL23A; RPL23; RPL19; RPL27; RPL38; RPS21; RPS15; RPL36; RPS28; RPL18A; UBA52; RPS16; RPS19; RPL18; RPL13A; RPS11; RPS9; RPL28; RPS5; RPL3
R-HSA-72613	Eukaryotic Translation Initiation	7.28	0.00e+00	0.00e+00	79/113	RPL22; RPL11; RPS8; RPL5; RPS27; RPS7; RPS27A; RPL31; RPL37A; RPL32; RPL15; RPSA; RPL14; RPL29; RPL24; EIF4A2; RPL35A; RPL9; RPL34; RPS3A; RPL37; RPS23; RPS14; RPS18; RPS10; RPL10A; RPS12; RPS4X; RPL36A; RPL39; RPL10; RPS20; RPL7; RPL30; PABPC1; RPL8; RPS6; RPL35; RPL12; RPL7A; RPLP2; RPL27A; RPS13; RPS3; RPS25; RPS24; RPL41; RPL6; RPLP0; RPL21; RPS29; RPL4; RPLP1; RPS17; RPS2; RPS15A; RPL13; EIF4A1; RPL26; RPL23A; RPL23; RPL19; RPL27; RPL38; RPS21; RPS15; RPL36; RPS28; RPL18A; UBA52; RPS16; RPS19; RPL18; RPL13A; RPS11; RPS9; RPL28; RPS5; RPL3
R-HSA-72737	Cap-dependent Translation Initiation	7.28	0.00e+00	0.00e+00	79/113	RPL22; RPL11; RPS8; RPL5; RPS27; RPS7; RPS27A; RPL31; RPL37A; RPL32; RPL15; RPSA; RPL14; RPL29; RPL24; EIF4A2; RPL35A; RPL9; RPL34; RPS3A; RPL37; RPS23; RPS14; RPS18; RPS10; RPL10A; RPS12; RPS4X; RPL36A; RPL39; RPL10; RPS20; RPL7; RPL30; PABPC1; RPL8; RPS6; RPL35; RPL12; RPL7A; RPLP2; RPL27A; RPS13; RPS3; RPS25; RPS24; RPL41; RPL6; RPLP0; RPL21; RPS29; RPL4; RPLP1; RPS17; RPS2; RPS15A; RPL13; EIF4A1; RPL26; RPL23A; RPL23; RPL19; RPL27; RPL38; RPS21; RPS15; RPL36; RPS28; RPL18A; UBA52; RPS16; RPS19; RPL18; RPL13A; RPS11; RPS9; RPL28; RPS5; RPL3
R-HSA-168273	Influenza Viral RNA Transcription and Replication	7.09	0.00e+00	0.00e+00	77/113	RPL22; RPL11; RPS8; RPL5; RPS27; RPS7; RPS27A; RPL31; RPL37A; RPL32; RPL15; RPSA; RPL14; RPL29; RPL24; RPL35A; RPL9; RPL34; RPS3A; RPL37; RPS23; RPS14; RPS18; RPS10; RPL10A; RPS12; RPS4X; RPL36A; RPL39; RPL10; RPS20; RPL7; RPL30; RPL8; RPS6; RPL35; RPL12; RPL7A; RPLP2; RPL27A; RPS13; RPS3; RPS25; RPS24; RPL41; RPL6; RPLP0; RPL21; RPS29; HSP90AA1; RPL4; RPLP1; RPS17; RPS2; RPS15A; RPL13; RPL26; RPL23A; RPL23; RPL19; RPL27; RPL38; RPS21; RPS15; RPL36; RPS28; RPL18A; UBA52; RPS16; RPS19; RPL18; RPL13A; RPS11; RPS9; RPL28; RPS5; RPL3
R-HSA-168255	Influenza Life Cycle	6.80	0.00e+00	0.00e+00	79/121	RPL22; RPL11; RPS8; RPL5; RPS27; RPS7; RPS27A; RPL31; RPL37A; RPL32; RPL15; RPSA; RPL14; RPL29; RPL24; RPL35A; RPL9; RPL34; RPS3A; RPL37; RPS23; RPS14; RPS18; RPS10; RPL10A; RPS12; RPS4X; RPL36A; RPL39; RPL10; RPS20; RPL7; RPL30; RPL8; RPS6; CLTA; RPL35; RPL12; RPL7A; RPLP2; RPL27A; RPS13; RPS3; RPS25; RPS24; RPL41; RPL6; RPLP0; RAN; RPL21; RPS29; HSP90AA1; RPL4; RPLP1; RPS17; RPS2; RPS15A; RPL13; RPL26; RPL23A; RPL23; RPL19; RPL27; RPL38; RPS21; RPS15; RPL36; RPS28; RPL18A; UBA52; RPS16; RPS19; RPL18; RPL13A; RPS11; RPS9; RPL28; RPS5; RPL3
R-HSA-9010553	Regulation of expression of SLITs and ROBOs	6.78	0.00e+00	0.00e+00	97/149	RPL22; RPL11; RPS8; RPL5; PSMA5; PSMD4; RPS27; RPS7; RPS27A; RPL31; RPL37A; RPL32; RPL15; RPSA; RPL14; RPL29; PSMD6; RPL24; RPL35A; RPL9; RPL34; RPS3A; RPL37; RPS23; RPS14; RPS18; RPS10; RPL10A; RPS12; PSMB1; PSMC2; RPS4X; RPL36A; RPL39; RPL10; RPS20; RPL7; TCEB1; RPL30; PABPC1; RPL8; RPS6; RPL35; RPL12; RPL7A; PSMD13; RPLP2; RPL27A; RPS13; RPS3; RPS25; RPS24; RPL41; RPL6; RPLP0; MSI1; UBC; RPL21; PSME2; RPS29; PSMA3; RPL4; RPLP1; PSMA4; RPS17; RPS2; RPS15A; PSMD7; RPL13; PSMB6; RPL26; RPL23A; PSMB3; RPL23; RPL19; RPL27; PSMC5; RPL38; EIF4A3; PSMA7; RPS21; RPS15; RPL36; RPS28; RPL18A; UBA52; PSMD8; RPS16; PSMC4; RPS19; RPL18; RPL13A; RPS11; RPS9; RPL28; RPS5; RPL3
R-HSA-72695	Formation of the ternary complex, and subsequently, the 43S complex	6.51	0.00e+00	0.00e+00	30/48	RPS8; RPS27; RPS7; RPS27A; RPSA; RPS3A; RPS23; RPS14; RPS18; RPS10; RPS12; RPS4X; RPS20; RPS6; RPS13; RPS3; RPS25; RPS24; RPS29; RPS17; RPS2; RPS15A; RPS21; RPS15; RPS28; RPS16; RPS19; RPS11; RPS9; RPS5
R-HSA-168254	Influenza Infection	6.51	0.00e+00	0.00e+00	80/128	RPL22; RPL11; RPS8; RPL5; RPS27; RPS7; RPS27A; RPL31; RPL37A; RPL32; RPL15; RPSA; RPL14; RPL29; RPL24; RPL35A; RPL9; RPL34; RPS3A; RPL37; RPS23; RPS14; RPS18; RPS10; RPL10A; RPS12; RPS4X; RPL36A; RPL39; RPL10; RPS20; RPL7; RPL30; RPL8; RPS6; CLTA; RPL35; RPL12; RPL7A; RPLP2; RPL27A; RPS13; RPS3; RPS25; RPS24; RPL41; RPL6; RPLP0; RAN; RPL21; RPS29; HSP90AA1; RPL4; RPLP1; RPS17; RPS2; RPS15A; RPL13; RPL26; RPL23A; RPL23; RPL19; RPL27; KPNA2; RPL38; RPS21; RPS15; RPL36; RPS28; RPL18A; UBA52; RPS16; RPS19; RPL18; RPL13A; RPS11; RPS9; RPL28; RPS5; RPL3
R-HSA-389960	Formation of tubulin folding intermediates by CCT/TriC	6.51	2.79e-07	1.95e-06	10/16	CCT7; TUBA4A; CCT5; TUBB2A; TUBB2B; TUBB4B; TUBA1B; TUBA1A; CCT2; TUBB3
R-HSA-389977	Post-chaperonin tubulin folding pathway	6.41	5.61e-06	3.22e-05	8/13	TUBA4A; TUBB2A; TUBB2B; TUBB4B; TUBA1B; TUBA1A; TUBB3; TBCB
R-HSA-190828	Gap junction trafficking	6.36	9.46e-08	8.76e-07	11/18	TUBA4A; AP2M1; TUBB2A; TUBB2B; ACTB; CLTA; TUBB4B; TUBA1B; TUBA1A; TUBB3; ACTG1
R-HSA-72649	Translation initiation complex formation	6.25	0.00e+00	0.00e+00	33/55	RPS8; RPS27; RPS7; RPS27A; RPSA; EIF4A2; RPS3A; RPS23; RPS14; RPS18; RPS10; RPS12; RPS4X; RPS20; PABPC1; RPS6; RPS13; RPS3; RPS25; RPS24; RPS29; RPS17; RPS2; RPS15A; EIF4A1; RPS21; RPS15; RPS28; RPS16; RPS19; RPS11; RPS9; RPS5
R-HSA-72662	Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S	6.13	0.00e+00	0.00e+00	33/56	RPS8; RPS27; RPS7; RPS27A; RPSA; EIF4A2; RPS3A; RPS23; RPS14; RPS18; RPS10; RPS12; RPS4X; RPS20; PABPC1; RPS6; RPS13; RPS3; RPS25; RPS24; RPS29; RPS17; RPS2; RPS15A; EIF4A1; RPS21; RPS15; RPS28; RPS16; RPS19; RPS11; RPS9; RPS5
R-HSA-8876725	Protein methylation	6.07	3.68e-05	1.98e-04	7/12	CALM2; HSPA8; CALM1; RPS2; EEF2; CALM3; ETFB
R-HSA-72702	Ribosomal scanning and start codon recognition	6.06	0.00e+00	0.00e+00	32/55	RPS8; RPS27; RPS7; RPS27A; RPSA; EIF4A2; RPS3A; RPS23; RPS14; RPS18; RPS10; RPS12; RPS4X; RPS20; RPS6; RPS13; RPS3; RPS25; RPS24; RPS29; RPS17; RPS2; RPS15A; EIF4A1; RPS21; RPS15; RPS28; RPS16; RPS19; RPS11; RPS9; RPS5
R-HSA-157858	Gap junction trafficking and regulation	6.03	2.05e-07	1.57e-06	11/19	TUBA4A; AP2M1; TUBB2A; TUBB2B; ACTB; CLTA; TUBB4B; TUBA1B; TUBA1A; TUBB3; ACTG1
R-HSA-8955332	Carboxyterminal post-translational modifications of tubulin	5.95	1.20e-05	6.66e-05	8/14	TUBA4A; TUBB2A; TUBB2B; TUBB4B; TUBA1B; TUBA1A; TUBB3; TPGS2
R-HSA-376176	Signaling by ROBO receptors	5.73	0.00e+00	0.00e+00	98/178	RPL22; CDC42; RPL11; RPS8; RPL5; PSMA5; PSMD4; RPS27; RPS7; RPS27A; RPL31; RPL37A; RPL32; RPL15; RPSA; RPL14; RPL29; PSMD6; RPL24; RPL35A; RPL9; RPL34; RPS3A; RPL37; RPS23; RPS14; RPS18; RPS10; RPL10A; RPS12; PSMB1; PSMC2; RPS4X; RPL36A; RPL39; RPL10; RPS20; RPL7; TCEB1; RPL30; PABPC1; RPL8; RPS6; RPL35; RPL12; RPL7A; PSMD13; RPLP2; RPL27A; RPS13; RPS3; RPS25; RPS24; RPL41; RPL6; RPLP0; MSI1; UBC; RPL21; PSME2; RPS29; PSMA3; RPL4; RPLP1; PSMA4; RPS17; RPS2; RPS15A; PSMD7; RPL13; PSMB6; RPL26; RPL23A; PSMB3; RPL23; RPL19; RPL27; PSMC5; RPL38; EIF4A3; PSMA7; RPS21; RPS15; RPL36; RPS28; RPL18A; UBA52; PSMD8; RPS16; PSMC4; RPS19; RPL18; RPL13A; RPS11; RPS9; RPL28; RPS5; RPL3
R-HSA-70263	Gluconeogenesis	5.48	2.47e-06	1.49e-05	10/19	ENO1; MDH1; MDH2; PGK1; PGAM1; GAPDH; TPI1; ALDOA; ENO3; G6PC3
R-HSA-8852276	The role of GTSE1 in G2/M progression after G2 checkpoint	5.30	3.89e-15	9.84e-14	28/55	PSMA5; PSMD4; RPS27A; TUBA4A; PSMD6; TUBB2A; TUBB2B; HSP90AB1; PSMB1; PSMC2; TUBB4B; PSMD13; TUBA1B; TUBA1A; UBC; PSME2; PSMA3; HSP90AA1; PSMA4; PSMD7; TUBB3; PSMB6; PSMB3; PSMC5; PSMA7; UBA52; PSMD8; PSMC4
R-HSA-175474	Assembly Of The HIV Virion	5.20	1.33e-03	6.01e-03	5/10	RPS27A; PPIA; TSG101; UBC; UBA52
R-HSA-5663084	Diseases of carbohydrate metabolism	5.20	1.33e-03	6.01e-03	5/10	RPS27A; TALDO1; UBC; G6PC3; UBA52
R-HSA-6791226	Major pathway of rRNA processing in the nucleolus and cytosol	5.14	0.00e+00	0.00e+00	76/154	RPL22; RPL11; RPS8; RPL5; RPS27; RPS7; RPS27A; RPL31; RPL37A; RPL32; RPL15; RPSA; RPL14; RPL29; RPL24; RPL35A; RPL9; RPL34; RPS3A; RPL37; RPS23; RPS14; RPS18; RPS10; RPL10A; RPS12; RPS4X; RPL36A; RPL39; RPL10; RPS20; RPL7; RPL30; RPL8; RPS6; RPL35; RPL12; RPL7A; RPLP2; RPL27A; RPS13; RPS3; RPS25; RPS24; RPL41; RPL6; RPLP0; RPL21; RPS29; RPL4; RPLP1; RPS17; RPS2; RPS15A; RPL13; RPL26; RPL23A; RPL23; RPL19; RPL27; RPL38; RPS21; RPS15; RPL36; RPS28; RPL18A; UBA52; RPS16; RPS19; RPL18; RPL13A; RPS11; RPS9; RPL28; RPS5; RPL3
R-HSA-389958	Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding	4.98	2.58e-06	1.54e-05	11/23	CCT7; TUBA4A; CCT5; TUBB2A; TUBB2B; ACTB; TUBB4B; TUBA1B; TUBA1A; CCT2; TUBB3
R-HSA-8868773	rRNA processing in the nucleus and cytosol	4.94	0.00e+00	0.00e+00	76/160	RPL22; RPL11; RPS8; RPL5; RPS27; RPS7; RPS27A; RPL31; RPL37A; RPL32; RPL15; RPSA; RPL14; RPL29; RPL24; RPL35A; RPL9; RPL34; RPS3A; RPL37; RPS23; RPS14; RPS18; RPS10; RPL10A; RPS12; RPS4X; RPL36A; RPL39; RPL10; RPS20; RPL7; RPL30; RPL8; RPS6; RPL35; RPL12; RPL7A; RPLP2; RPL27A; RPS13; RPS3; RPS25; RPS24; RPL41; RPL6; RPLP0; RPL21; RPS29; RPL4; RPLP1; RPS17; RPS2; RPS15A; RPL13; RPL26; RPL23A; RPL23; RPL19; RPL27; RPL38; RPS21; RPS15; RPL36; RPS28; RPL18A; UBA52; RPS16; RPS19; RPL18; RPL13A; RPS11; RPS9; RPL28; RPS5; RPL3
R-HSA-71291	Metabolism of amino acids and derivatives	4.93	0.00e+00	0.00e+00	99/209	RPL22; RPL11; RPS8; RPL5; PSMA5; PHGDH; PSMD4; RPS27; RPS7; RPS27A; RPL31; RPL37A; RPL32; RPL15; RPSA; RPL14; RPL29; PDHB; PSMD6; RPL24; RPL35A; RPL9; RPL34; RPS3A; RPL37; RPS23; CDO1; RPS14; RPS18; RPS10; RPL10A; RPS12; PSMB1; ASNS; PSMC2; PDHA1; HSD17B10; RPS4X; RPL36A; RPL39; RPL10; RPS20; RPL7; RPL30; RPL8; RPS6; RPL35; RPL12; RPL7A; PSMD13; RPLP2; RPL27A; RPS13; RPS3; RPS25; RPS24; RPL41; RPL6; RPLP0; RPL21; PSME2; RPS29; PSMA3; CKB; RPL4; RPLP1; PSMA4; RPS17; RPS2; RPS15A; PSMD7; RPL13; PSMB6; RPL26; RPL23A; PSMB3; RPL23; RPL19; RPL27; PSMC5; RPL38; PSMA7; RPS21; RPS15; RPL36; RPS28; RPL18A; UBA52; PSMD8; RPS16; PSMC4; RPS19; RPL18; RPL13A; RPS11; RPS9; RPL28; RPS5; RPL3
R-HSA-72312	rRNA processing	4.89	0.00e+00	0.00e+00	77/164	RPL22; RPL11; RPS8; RPL5; RPS27; RPS7; RPS27A; RPL31; RPL37A; RPL32; RPL15; RPSA; RPL14; RPL29; RPL24; RPL35A; RPL9; RPL34; RPS3A; RPL37; RPS23; RPS14; RPS18; RPS10; RPL10A; RPS12; HSD17B10; RPS4X; RPL36A; RPL39; RPL10; RPS20; RPL7; RPL30; RPL8; RPS6; RPL35; RPL12; RPL7A; RPLP2; RPL27A; RPS13; RPS3; RPS25; RPS24; RPL41; RPL6; RPLP0; RPL21; RPS29; RPL4; RPLP1; RPS17; RPS2; RPS15A; RPL13; RPL26; RPL23A; RPL23; RPL19; RPL27; RPL38; RPS21; RPS15; RPL36; RPS28; RPL18A; UBA52; RPS16; RPS19; RPL18; RPL13A; RPS11; RPS9; RPL28; RPS5; RPL3
R-HSA-180534	Vpu mediated degradation of CD4	4.84	3.20e-10	7.06e-09	20/43	PSMA5; PSMD4; RPS27A; PSMD6; SKP1; PSMB1; PSMC2; PSMD13; UBC; PSME2; PSMA3; PSMA4; PSMD7; PSMB6; PSMB3; PSMC5; PSMA7; UBA52; PSMD8; PSMC4
R-HSA-3371497	HSP90 chaperone cycle for steroid hormone receptors (SHR)	4.78	9.10e-09	1.10e-07	17/37	CAPZB; TUBA4A; TUBB2A; TUBB2B; HSP90AB1; DNAJA1; DCTN3; TUBB4B; HSPA8; TUBA1B; TUBA1A; PTGES3; DCTN2; DYNLL1; ACTR10; HSP90AA1; TUBB3
R-HSA-174113	SCF-beta-TrCP mediated degradation of Emi1	4.73	5.36e-10	1.15e-08	20/44	PSMA5; PSMD4; RPS27A; PSMD6; SKP1; PSMB1; PSMC2; PSMD13; UBC; PSME2; PSMA3; PSMA4; PSMD7; PSMB6; PSMB3; PSMC5; PSMA7; UBA52; PSMD8; PSMC4
R-HSA-389957	Prefoldin mediated transfer of substrate to CCT/TriC	4.73	1.33e-05	7.27e-05	10/22	CCT7; TUBA4A; CCT5; TUBB2A; TUBB2B; ACTB; TUBB4B; TUBA1A; CCT2; TUBB3
R-HSA-450408	AUF1 (hnRNP D0) binds and destabilizes mRNA	4.65	2.90e-10	6.57e-09	21/47	PSMA5; PSMD4; RPS27A; PSMD6; PSMB1; PSMC2; PABPC1; PSMD13; HSPA8; UBC; PSME2; PSMA3; PSMA4; PSMD7; PSMB6; PSMB3; PSMC5; PSMA7; UBA52; PSMD8; PSMC4
R-HSA-8854050	FBXL7 down-regulates AURKA during mitotic entry and in early mitosis	4.63	8.81e-10	1.85e-08	20/45	PSMA5; PSMD4; RPS27A; PSMD6; SKP1; PSMB1; PSMC2; PSMD13; UBC; PSME2; PSMA3; PSMA4; PSMD7; PSMB6; PSMB3; PSMC5; PSMA7; UBA52; PSMD8; PSMC4
R-HSA-211733	Regulation of activated PAK-2p34 by proteasome mediated degradation	4.60	2.67e-09	4.26e-08	19/43	PSMA5; PSMD4; RPS27A; PSMD6; PSMB1; PSMC2; PSMD13; UBC; PSME2; PSMA3; PSMA4; PSMD7; PSMB6; PSMB3; PSMC5; PSMA7; UBA52; PSMD8; PSMC4
R-HSA-69601	Ubiquitin Mediated Degradation of Phosphorylated Cdc25A	4.60	2.67e-09	4.26e-08	19/43	PSMA5; PSMD4; RPS27A; PSMD6; PSMB1; PSMC2; PSMD13; UBC; PSME2; PSMA3; PSMA4; PSMD7; PSMB6; PSMB3; PSMC5; PSMA7; UBA52; PSMD8; PSMC4
R-HSA-69610	p53-Independent DNA Damage Response	4.60	2.67e-09	4.26e-08	19/43	PSMA5; PSMD4; RPS27A; PSMD6; PSMB1; PSMC2; PSMD13; UBC; PSME2; PSMA3; PSMA4; PSMD7; PSMB6; PSMB3; PSMC5; PSMA7; UBA52; PSMD8; PSMC4
R-HSA-69613	p53-Independent G1/S DNA damage checkpoint	4.60	2.67e-09	4.26e-08	19/43	PSMA5; PSMD4; RPS27A; PSMD6; PSMB1; PSMC2; PSMD13; UBC; PSME2; PSMA3; PSMA4; PSMD7; PSMB6; PSMB3; PSMC5; PSMA7; UBA52; PSMD8; PSMC4
R-HSA-180585	Vif-mediated degradation of APOBEC3G	4.53	1.42e-09	2.85e-08	20/46	PSMA5; PSMD4; RPS27A; PSMD6; PSMB1; PSMC2; TCEB1; PSMD13; UBC; PSME2; PSMA3; PSMA4; PSMD7; PSMB6; PSMB3; PSMC5; PSMA7; UBA52; PSMD8; PSMC4
R-HSA-69229	Ubiquitin-dependent degradation of Cyclin D1	4.49	4.29e-09	5.87e-08	19/44	PSMA5; PSMD4; RPS27A; PSMD6; PSMB1; PSMC2; PSMD13; UBC; PSME2; PSMA3; PSMA4; PSMD7; PSMB6; PSMB3; PSMC5; PSMA7; UBA52; PSMD8; PSMC4
R-HSA-75815	Ubiquitin-dependent degradation of Cyclin D	4.49	4.29e-09	5.87e-08	19/44	PSMA5; PSMD4; RPS27A; PSMD6; PSMB1; PSMC2; PSMD13; UBC; PSME2; PSMA3; PSMA4; PSMD7; PSMB6; PSMB3; PSMC5; PSMA7; UBA52; PSMD8; PSMC4
R-HSA-169911	Regulation of Apoptosis	4.49	4.29e-09	5.87e-08	19/44	PSMA5; PSMD4; RPS27A; PSMD6; PSMB1; PSMC2; PSMD13; UBC; PSME2; PSMA3; PSMA4; PSMD7; PSMB6; PSMB3; PSMC5; PSMA7; UBA52; PSMD8; PSMC4
R-HSA-8982491	Glycogen metabolism	4.46	1.16e-03	5.28e-03	6/14	CALM2; RPS27A; UBC; CALM1; UBA52; CALM3
R-HSA-187577	SCF(Skp2)-mediated degradation of p27/p21	4.43	2.26e-09	3.90e-08	20/47	PSMA5; PSMD4; RPS27A; PSMD6; SKP1; PSMB1; PSMC2; PSMD13; UBC; PSME2; PSMA3; PSMA4; PSMD7; PSMB6; PSMB3; PSMC5; PSMA7; UBA52; PSMD8; PSMC4
R-HSA-5607761	Dectin-1 mediated noncanonical NF-kB signaling	4.43	2.26e-09	3.90e-08	20/47	PSMA5; PSMD4; RPS27A; PSMD6; SKP1; PSMB1; PSMC2; PSMD13; UBC; PSME2; PSMA3; PSMA4; PSMD7; PSMB6; PSMB3; PSMC5; PSMA7; UBA52; PSMD8; PSMC4
R-HSA-5676590	NIK-->noncanonical NF-kB signaling	4.43	2.26e-09	3.90e-08	20/47	PSMA5; PSMD4; RPS27A; PSMD6; SKP1; PSMB1; PSMC2; PSMD13; UBC; PSME2; PSMA3; PSMA4; PSMD7; PSMB6; PSMB3; PSMC5; PSMA7; UBA52; PSMD8; PSMC4
R-HSA-9604323	Negative regulation of NOTCH4 signaling	4.43	2.26e-09	3.90e-08	20/47	PSMA5; PSMD4; RPS27A; PSMD6; SKP1; PSMB1; PSMC2; PSMD13; UBC; PSME2; PSMA3; PSMA4; PSMD7; PSMB6; PSMB3; PSMC5; PSMA7; UBA52; PSMD8; PSMC4
R-HSA-349425	Autodegradation of the E3 ubiquitin ligase COP1	4.39	6.79e-09	8.35e-08	19/45	PSMA5; PSMD4; RPS27A; PSMD6; PSMB1; PSMC2; PSMD13; UBC; PSME2; PSMA3; PSMA4; PSMD7; PSMB6; PSMB3; PSMC5; PSMA7; UBA52; PSMD8; PSMC4
R-HSA-4641258	Degradation of DVL	4.39	6.79e-09	8.35e-08	19/45	PSMA5; PSMD4; RPS27A; PSMD6; PSMB1; PSMC2; PSMD13; UBC; PSME2; PSMA3; PSMA4; PSMD7; PSMB6; PSMB3; PSMC5; PSMA7; UBA52; PSMD8; PSMC4
R-HSA-68827	CDT1 association with the CDC6:ORC:origin complex	4.39	6.79e-09	8.35e-08	19/45	PSMA5; PSMD4; RPS27A; PSMD6; PSMB1; PSMC2; PSMD13; UBC; PSME2; PSMA3; PSMA4; PSMD7; PSMB6; PSMB3; PSMC5; PSMA7; UBA52; PSMD8; PSMC4
R-HSA-8941858	Regulation of RUNX3 expression and activity	4.39	6.79e-09	8.35e-08	19/45	PSMA5; PSMD4; RPS27A; PSMD6; PSMB1; PSMC2; PSMD13; UBC; PSME2; PSMA3; PSMA4; PSMD7; PSMB6; PSMB3; PSMC5; PSMA7; UBA52; PSMD8; PSMC4
R-HSA-1236974	ER-Phagosome pathway	4.37	1.18e-09	2.43e-08	21/50	PSMA5; PSMD4; RPS27A; PSMD6; HLA-A; PSMB1; PSMC2; PSMD13; UBC; PSME2; PSMA3; PDIA3; PSMA4; PSMD7; PSMB6; PSMB3; PSMC5; PSMA7; UBA52; PSMD8; PSMC4
R-HSA-68949	Orc1 removal from chromatin	4.34	3.54e-09	5.17e-08	20/48	PSMA5; PSMD4; RPS27A; PSMD6; SKP1; PSMB1; PSMC2; PSMD13; UBC; PSME2; PSMA3; PSMA4; PSMD7; PSMB6; PSMB3; PSMC5; PSMA7; UBA52; PSMD8; PSMC4
R-HSA-1169091	Activation of NF-kappaB in B cells	4.34	3.54e-09	5.17e-08	20/48	PSMA5; PSMD4; RPS27A; PSMD6; SKP1; PSMB1; PSMC2; PSMD13; UBC; PSME2; PSMA3; PSMA4; PSMD7; PSMB6; PSMB3; PSMC5; PSMA7; UBA52; PSMD8; PSMC4
R-HSA-5610780	Degradation of GLI1 by the proteasome	4.34	3.54e-09	5.17e-08	20/48	PSMA5; PSMD4; RPS27A; PSMD6; SKP1; PSMB1; PSMC2; PSMD13; UBC; PSME2; PSMA3; PSMA4; PSMD7; PSMB6; PSMB3; PSMC5; PSMA7; UBA52; PSMD8; PSMC4
R-HSA-5668541	TNFR2 non-canonical NF-kB pathway	4.34	3.54e-09	5.17e-08	20/48	PSMA5; PSMD4; RPS27A; PSMD6; SKP1; PSMB1; PSMC2; PSMD13; UBC; PSME2; PSMA3; PSMA4; PSMD7; PSMB6; PSMB3; PSMC5; PSMA7; UBA52; PSMD8; PSMC4
R-HSA-156590	Glutathione conjugation	4.34	3.56e-03	1.46e-02	5/12	GSTM3; MGST3; GSTA4; GSTP1; ESD
R-HSA-202131	Metabolism of nitric oxide	4.34	3.56e-03	1.46e-02	5/12	CALM2; DDAH2; CALM1; HSP90AA1; CALM3
R-HSA-203765	eNOS activation and regulation	4.34	3.56e-03	1.46e-02	5/12	CALM2; DDAH2; CALM1; HSP90AA1; CALM3
R-HSA-1168372	Downstream signaling events of B Cell Receptor (BCR)	4.31	1.07e-10	2.48e-09	24/58	PSMA5; PSMD4; CALM2; RPS27A; PSMD6; SKP1; PSMB1; PPIA; PSMC2; PSMD13; UBC; PSME2; PSMA3; CALM1; PSMA4; PSMD7; PSMB6; PSMB3; PSMC5; PSMA7; UBA52; PSMD8; PSMC4; CALM3
R-HSA-4641257	Degradation of AXIN	4.30	1.06e-08	1.26e-07	19/46	PSMA5; PSMD4; RPS27A; PSMD6; PSMB1; PSMC2; PSMD13; UBC; PSME2; PSMA3; PSMA4; PSMD7; PSMB6; PSMB3; PSMC5; PSMA7; UBA52; PSMD8; PSMC4
R-HSA-1236975	Antigen processing-Cross presentation	4.29	1.84e-09	3.44e-08	21/51	PSMA5; PSMD4; RPS27A; PSMD6; HLA-A; PSMB1; PSMC2; PSMD13; UBC; PSME2; PSMA3; PDIA3; PSMA4; PSMD7; PSMB6; PSMB3; PSMC5; PSMA7; UBA52; PSMD8; PSMC4
R-HSA-1236978	Cross-presentation of soluble exogenous antigens (endosomes)	4.27	1.79e-07	1.39e-06	16/39	PSMA5; PSMD4; PSMD6; PSMB1; PSMC2; PSMD13; PSME2; PSMA3; PSMA4; PSMD7; PSMB6; PSMB3; PSMC5; PSMA7; PSMD8; PSMC4
R-HSA-5610783	Degradation of GLI2 by the proteasome	4.25	5.47e-09	7.13e-08	20/49	PSMA5; PSMD4; RPS27A; PSMD6; SKP1; PSMB1; PSMC2; PSMD13; UBC; PSME2; PSMA3; PSMA4; PSMD7; PSMB6; PSMB3; PSMC5; PSMA7; UBA52; PSMD8; PSMC4
R-HSA-5610785	GLI3 is processed to GLI3R by the proteasome	4.25	5.47e-09	7.13e-08	20/49	PSMA5; PSMD4; RPS27A; PSMD6; SKP1; PSMB1; PSMC2; PSMD13; UBC; PSME2; PSMA3; PSMA4; PSMD7; PSMB6; PSMB3; PSMC5; PSMA7; UBA52; PSMD8; PSMC4
R-HSA-5362768	Hh mutants that don't undergo autocatalytic processing are degraded by ERAD	4.21	1.62e-08	1.81e-07	19/47	PSMA5; PSMD4; RPS27A; PSMD6; PSMB1; PSMC2; PSMD13; UBC; PSME2; PSMA3; PSMA4; PSMD7; PSMB6; PSMB3; PSMC5; PSMA7; UBA52; PSMD8; PSMC4
R-HSA-5387390	Hh mutants abrogate ligand secretion	4.21	1.62e-08	1.81e-07	19/47	PSMA5; PSMD4; RPS27A; PSMD6; PSMB1; PSMC2; PSMD13; UBC; PSME2; PSMA3; PSMA4; PSMD7; PSMB6; PSMB3; PSMC5; PSMA7; UBA52; PSMD8; PSMC4
R-HSA-68867	Assembly of the pre-replicative complex	4.21	1.62e-08	1.81e-07	19/47	PSMA5; PSMD4; RPS27A; PSMD6; PSMB1; PSMC2; PSMD13; UBC; PSME2; PSMA3; PSMA4; PSMD7; PSMB6; PSMB3; PSMC5; PSMA7; UBA52; PSMD8; PSMC4
R-HSA-5663205	Infectious disease	4.20	0.00e+00	0.00e+00	111/275	RPL22; RPL11; RPS8; RPL5; PSMA5; PSMD4; RPS27; RPS7; CALM2; RPS27A; RPL31; RPL37A; RPL32; RPL15; RPSA; RPL14; CTNNB1; RPL29; PSMD6; RPL24; AP2M1; RPL35A; RPL9; RPL34; RPS3A; SLC25A4; RPL37; RPS23; SKP1; RPS14; RPS18; RPS10; RPL10A; HSP90AB1; RPS12; PSMB1; PPIA; PSMC2; RPS4X; RPL36A; RPL39; RPL10; RPS20; RPL7; TCEB1; RPL30; RPL8; RPS6; CHMP5; CLTA; RPL35; RPL12; RPL7A; PSMD13; RPLP2; RPL27A; RPS13; TSG101; RPS3; RPS25; RPS24; RPL41; RPL6; RPLP0; UBC; RAN; RPL21; PSME2; RPS29; PSMA3; CALM1; HSP90AA1; RPL4; RPLP1; PSMA4; RPS17; RPS2; RPS15A; PSMD7; RPL13; PSMB6; RPL26; RPL23A; PSMB3; RPL23; RPL19; RPL27; PSMC5; KPNA2; RPL38; PSMA7; RPS21; RPS15; EEF2; RPL36; RPS28; RPL18A; UBA52; PSMD8; RPS16; PSMC4; RPS19; CALM3; RPL18; RPL13A; RPS11; RPS9; RPL28; RPS5; CHMP2A; RPL3
R-HSA-70268	Pyruvate metabolism	4.16	1.78e-03	7.80e-03	6/15	PDHB; VDAC1; PDHA1; LDHA; LDHB; BSG
R-HSA-9013507	NOTCH3 Activation and Transmission of Signal to the Nucleus	4.16	1.10e-02	4.05e-02	4/10	RPS27A; UBC; UBA52; PSENEN
R-HSA-3371568	Attenuation phase	4.16	1.10e-02	4.05e-02	4/10	HSP90AB1; HSPA8; PTGES3; HSP90AA1
R-HSA-4608870	Asymmetric localization of PCP proteins	4.12	2.45e-08	2.63e-07	19/48	PSMA5; PSMD4; RPS27A; PSMD6; PSMB1; PSMC2; PSMD13; UBC; PSME2; PSMA3; PSMA4; PSMD7; PSMB6; PSMB3; PSMC5; PSMA7; UBA52; PSMD8; PSMC4
R-HSA-69541	Stabilization of p53	4.12	2.45e-08	2.63e-07	19/48	PSMA5; PSMD4; RPS27A; PSMD6; PSMB1; PSMC2; PSMD13; UBC; PSME2; PSMA3; PSMA4; PSMD7; PSMB6; PSMB3; PSMC5; PSMA7; UBA52; PSMD8; PSMC4
R-HSA-8939902	Regulation of RUNX2 expression and activity	4.08	1.25e-08	1.48e-07	20/51	PSMA5; PSMD4; RPS27A; PSMD6; SKP1; PSMB1; PSMC2; PSMD13; UBC; PSME2; PSMA3; PSMA4; PSMD7; PSMB6; PSMB3; PSMC5; PSMA7; UBA52; PSMD8; PSMC4
R-HSA-5610787	Hedgehog 'off' state	4.07	3.29e-11	7.87e-10	27/69	PSMA5; PSMD4; RPS27A; TUBA4A; PSMD6; SKP1; TUBB2A; TUBB2B; PSMB1; PSMC2; TUBB4B; PSMD13; TUBA1B; TUBA1A; UBC; PSME2; PSMA3; PSMA4; PSMD7; TUBB3; PSMB6; PSMB3; PSMC5; PSMA7; UBA52; PSMD8; PSMC4
R-HSA-163210	Formation of ATP by chemiosmotic coupling	4.05	8.87e-04	4.17e-03	7/18	ATP5F1; ATP5G3; ATP5C1; ATP5B; ATP5A1; ATP5J; ATP5O
R-HSA-3299685	Detoxification of Reactive Oxygen Species	4.05	8.87e-04	4.17e-03	7/18	PRDX1; CYCS; TXN; PRDX5; GSTP1; PRDX2; SOD1
R-HSA-5678895	Defective CFTR causes cystic fibrosis	4.04	3.65e-08	3.70e-07	19/49	PSMA5; PSMD4; RPS27A; PSMD6; PSMB1; PSMC2; PSMD13; UBC; PSME2; PSMA3; PSMA4; PSMD7; PSMB6; PSMB3; PSMC5; PSMA7; UBA52; PSMD8; PSMC4
R-HSA-1234176	Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha	4.00	1.86e-08	2.05e-07	20/52	PSMA5; PSMD4; RPS27A; PSMD6; PSMB1; PSMC2; TCEB1; PSMD13; UBC; PSME2; PSMA3; PSMA4; PSMD7; PSMB6; PSMB3; PSMC5; PSMA7; UBA52; PSMD8; PSMC4
R-HSA-5607764	CLEC7A (Dectin-1) signaling	3.99	1.64e-09	3.21e-08	23/60	PSMA5; PSMD4; CALM2; RPS27A; PSMD6; SKP1; PSMB1; PSMC2; PSMD13; UBC; PSME2; PSMA3; CALM1; PSMA4; PSMD7; PSMB6; PSMB3; PSMC5; PSMA7; UBA52; PSMD8; PSMC4; CALM3
R-HSA-5358346	Hedgehog ligand biogenesis	3.96	5.38e-08	5.26e-07	19/50	PSMA5; PSMD4; RPS27A; PSMD6; PSMB1; PSMC2; PSMD13; UBC; PSME2; PSMA3; PSMA4; PSMD7; PSMB6; PSMB3; PSMC5; PSMA7; UBA52; PSMD8; PSMC4
R-HSA-437239	Recycling pathway of L1	3.95	3.87e-05	2.07e-04	11/29	TUBA4A; AP2M1; TUBB2A; TUBB2B; ACTB; CLTA; TUBB4B; TUBA1B; TUBA1A; TUBB3; ACTG1
R-HSA-2871837	FCERI mediated NF-kB activation	3.93	2.72e-08	2.82e-07	20/53	PSMA5; PSMD4; RPS27A; PSMD6; SKP1; PSMB1; PSMC2; PSMD13; UBC; PSME2; PSMA3; PSMA4; PSMD7; PSMB6; PSMB3; PSMC5; PSMA7; UBA52; PSMD8; PSMC4
R-HSA-202424	Downstream TCR signaling	3.93	2.72e-08	2.82e-07	20/53	PSMA5; PSMD4; RPS27A; PSMD6; SKP1; PSMB1; PSMC2; PSMD13; UBC; PSME2; PSMA3; PSMA4; PSMD7; PSMB6; PSMB3; PSMC5; PSMA7; UBA52; PSMD8; PSMC4
R-HSA-422475	Axon guidance	3.90	0.00e+00	0.00e+00	123/328	RPL22; CDC42; RPL11; RPS8; RPL5; PSMA5; PSMD4; RPS27; ARPC5; RPS7; RPS27A; RPL31; RPL37A; ARPC2; TUBA4A; RPL32; RPL15; RPSA; RPL14; RPL29; PSMD6; RPL24; GAP43; AP2M1; RPL35A; RPL9; RPL34; RPS3A; RPL37; RPS23; RPS14; TUBB2A; TUBB2B; CSNK2B; RPS18; RPS10; RPL10A; HSP90AB1; RPS12; PSMB1; ACTB; ARPC1A; PSMC2; RPS4X; RPL36A; RPL39; RPL10; RPS20; SDCBP; RPL7; TCEB1; RPL30; PABPC1; RPL8; RPS6; CLTA; RPL35; RPL12; RPL7A; TUBB4B; PSMD13; RPLP2; RPL27A; RPS13; CFL1; RPS3; RPS25; HSPA8; RPS24; TUBA1B; TUBA1A; RPL41; MYL6; ARPC3; RPL6; RPLP0; MSI1; UBC; RPL21; PSME2; RPS29; PSMA3; HSP90AA1; RPL4; RPLP1; PSMA4; RPS17; RPS2; RPS15A; PSMD7; RPL13; TUBB3; PSMB6; RPL26; RPL23A; PSMB3; RPL23; RPL19; RPL27; PSMC5; RPL38; EIF4A3; ACTG1; MYL12B; PSMA7; RPS21; RPS15; RPL36; RPS28; RPL18A; UBA52; PSENEN; PSMD8; RPS16; PSMC4; RPS19; RPL18; RPL13A; RPS11; RPS9; RPL28; RPS5; RPL3
R-HSA-5619084	ABC transporter disorders	3.88	7.83e-08	7.41e-07	19/51	PSMA5; PSMD4; RPS27A; PSMD6; PSMB1; PSMC2; PSMD13; UBC; PSME2; PSMA3; PSMA4; PSMD7; PSMB6; PSMB3; PSMC5; PSMA7; UBA52; PSMD8; PSMC4
R-HSA-350562	Regulation of ornithine decarboxylase (ODC)	3.87	8.79e-07	5.48e-06	16/43	PSMA5; PSMD4; PSMD6; PSMB1; PSMC2; PSMD13; PSME2; PSMA3; PSMA4; PSMD7; PSMB6; PSMB3; PSMC5; PSMA7; PSMD8; PSMC4
R-HSA-983705	Signaling by the B Cell Receptor (BCR)	3.84	1.75e-09	3.35e-08	24/65	PSMA5; PSMD4; CALM2; RPS27A; PSMD6; SKP1; PSMB1; PPIA; PSMC2; PSMD13; UBC; PSME2; PSMA3; CALM1; PSMA4; PSMD7; PSMB6; PSMB3; PSMC5; PSMA7; UBA52; PSMD8; PSMC4; CALM3
R-HSA-5658442	Regulation of RAS by GAPs	3.80	1.13e-07	9.12e-07	19/52	PSMA5; PSMD4; RPS27A; PSMD6; PSMB1; PSMC2; PSMD13; UBC; PSME2; PSMA3; PSMA4; PSMD7; PSMB6; PSMB3; PSMC5; PSMA7; UBA52; PSMD8; PSMC4
R-HSA-69002	DNA Replication Pre-Initiation	3.80	1.13e-07	9.12e-07	19/52	PSMA5; PSMD4; RPS27A; PSMD6; PSMB1; PSMC2; PSMD13; UBC; PSME2; PSMA3; PSMA4; PSMD7; PSMB6; PSMB3; PSMC5; PSMA7; UBA52; PSMD8; PSMC4
R-HSA-69563	p53-Dependent G1 DNA Damage Response	3.80	1.13e-07	9.12e-07	19/52	PSMA5; PSMD4; RPS27A; PSMD6; PSMB1; PSMC2; PSMD13; UBC; PSME2; PSMA3; PSMA4; PSMD7; PSMB6; PSMB3; PSMC5; PSMA7; UBA52; PSMD8; PSMC4
R-HSA-69580	p53-Dependent G1/S DNA damage checkpoint	3.80	1.13e-07	9.12e-07	19/52	PSMA5; PSMD4; RPS27A; PSMD6; PSMB1; PSMC2; PSMD13; UBC; PSME2; PSMA3; PSMA4; PSMD7; PSMB6; PSMB3; PSMC5; PSMA7; UBA52; PSMD8; PSMC4
R-HSA-69615	G1/S DNA Damage Checkpoints	3.80	1.13e-07	9.12e-07	19/52	PSMA5; PSMD4; RPS27A; PSMD6; PSMB1; PSMC2; PSMD13; UBC; PSME2; PSMA3; PSMA4; PSMD7; PSMB6; PSMB3; PSMC5; PSMA7; UBA52; PSMD8; PSMC4
R-HSA-174084	Autodegradation of Cdh1 by Cdh1:APC/C	3.80	1.13e-07	9.12e-07	19/52	PSMA5; PSMD4; RPS27A; PSMD6; PSMB1; PSMC2; PSMD13; UBC; PSME2; PSMA3; PSMA4; PSMD7; PSMB6; PSMB3; PSMC5; PSMA7; UBA52; PSMD8; PSMC4
R-HSA-5632684	Hedgehog 'on' state	3.80	1.13e-07	9.12e-07	19/52	PSMA5; PSMD4; RPS27A; PSMD6; PSMB1; PSMC2; PSMD13; UBC; PSME2; PSMA3; PSMA4; PSMD7; PSMB6; PSMB3; PSMC5; PSMA7; UBA52; PSMD8; PSMC4
R-HSA-8948751	Regulation of PTEN stability and activity	3.79	5.67e-08	5.48e-07	20/55	PSMA5; PSMD4; RPS27A; PSMD6; CSNK2B; PSMB1; PSMC2; PSMD13; UBC; PSME2; PSMA3; PSMA4; PSMD7; PSMB6; PSMB3; PSMC5; PSMA7; UBA52; PSMD8; PSMC4
R-HSA-9013694	Signaling by NOTCH4	3.77	2.85e-08	2.92e-07	21/58	PSMA5; PSMD4; RPS27A; PSMD6; SKP1; PSMB1; PSMC2; PSMD13; UBC; PSME2; PSMA3; PSMA4; PSMD7; PSMB6; PSMB3; PSMC5; PSMA7; UBA52; PSENEN; PSMD8; PSMC4
R-HSA-69017	CDK-mediated phosphorylation and removal of Cdc6	3.73	1.60e-07	1.26e-06	19/53	PSMA5; PSMD4; RPS27A; PSMD6; PSMB1; PSMC2; PSMD13; UBC; PSME2; PSMA3; PSMA4; PSMD7; PSMB6; PSMB3; PSMC5; PSMA7; UBA52; PSMD8; PSMC4
R-HSA-176408	Regulation of APC/C activators between G1/S and early anaphase	3.72	8.05e-08	7.54e-07	20/56	PSMA5; PSMD4; RPS27A; PSMD6; SKP1; PSMB1; PSMC2; PSMD13; UBC; PSME2; PSMA3; PSMA4; PSMD7; PSMB6; PSMB3; PSMC5; PSMA7; UBA52; PSMD8; PSMC4
R-HSA-9020702	Interleukin-1 signaling	3.70	4.04e-08	4.04e-07	21/59	PSMA5; PSMD4; RPS27A; PSMD6; SKP1; PSMB1; PSMC2; PSMD13; UBC; HMGB1; PSME2; PSMA3; PSMA4; PSMD7; PSMB6; PSMB3; PSMC5; PSMA7; UBA52; PSMD8; PSMC4
R-HSA-1445148	Translocation of SLC2A4 (GLUT4) to the plasma membrane	3.70	1.79e-06	1.08e-05	16/45	YWHAQ; CALM2; TUBA4A; TUBB2A; TUBB2B; ACTB; RALA; TUBB4B; TUBA1B; TUBA1A; CALM1; TUBB3; YWHAE; ACTG1; YWHAB; CALM3
R-HSA-5339562	Uptake and actions of bacterial toxins	3.67	3.72e-03	1.50e-02	6/17	CALM2; HSP90AB1; CALM1; HSP90AA1; EEF2; CALM3
R-HSA-445355	Smooth Muscle Contraction	3.67	3.72e-03	1.50e-02	6/17	TPM3; CALM2; MYL6; CALM1; MYL12B; CALM3
R-HSA-174154	APC/C:Cdc20 mediated degradation of Securin	3.66	2.26e-07	1.64e-06	19/54	PSMA5; PSMD4; RPS27A; PSMD6; PSMB1; PSMC2; PSMD13; UBC; PSME2; PSMA3; PSMA4; PSMD7; PSMB6; PSMB3; PSMC5; PSMA7; UBA52; PSMD8; PSMC4
R-HSA-174178	APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1	3.66	2.26e-07	1.64e-06	19/54	PSMA5; PSMD4; RPS27A; PSMD6; PSMB1; PSMC2; PSMD13; UBC; PSME2; PSMA3; PSMA4; PSMD7; PSMB6; PSMB3; PSMC5; PSMA7; UBA52; PSMD8; PSMC4
R-HSA-174184	Cdc20:Phospho-APC/C mediated degradation of Cyclin A	3.66	2.26e-07	1.64e-06	19/54	PSMA5; PSMD4; RPS27A; PSMD6; PSMB1; PSMC2; PSMD13; UBC; PSME2; PSMA3; PSMA4; PSMD7; PSMB6; PSMB3; PSMC5; PSMA7; UBA52; PSMD8; PSMC4
R-HSA-179419	APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint	3.66	2.26e-07	1.64e-06	19/54	PSMA5; PSMD4; RPS27A; PSMD6; PSMB1; PSMC2; PSMD13; UBC; PSME2; PSMA3; PSMA4; PSMD7; PSMB6; PSMB3; PSMC5; PSMA7; UBA52; PSMD8; PSMC4
R-HSA-6811436	COPI-independent Golgi-to-ER retrograde traffic	3.66	1.99e-05	1.08e-04	13/37	CAPZB; TUBA4A; TUBB2A; TUBB2B; DCTN3; TUBB4B; TUBA1B; TUBA1A; DCTN2; DYNLL1; ACTR10; TUBB3; PAFAH1B3
R-HSA-69202	Cyclin E associated events during G1/S transition	3.65	1.13e-07	9.12e-07	20/57	PSMA5; PSMD4; RPS27A; PSMD6; SKP1; PSMB1; PSMC2; PSMD13; UBC; PSME2; PSMA3; PSMA4; PSMD7; PSMB6; PSMB3; PSMC5; PSMA7; UBA52; PSMD8; PSMC4
R-HSA-69656	Cyclin A:Cdk2-associated events at S phase entry	3.65	1.13e-07	9.12e-07	20/57	PSMA5; PSMD4; RPS27A; PSMD6; SKP1; PSMB1; PSMC2; PSMD13; UBC; PSME2; PSMA3; PSMA4; PSMD7; PSMB6; PSMB3; PSMC5; PSMA7; UBA52; PSMD8; PSMC4
R-HSA-174143	APC/C-mediated degradation of cell cycle proteins	3.65	1.13e-07	9.12e-07	20/57	PSMA5; PSMD4; RPS27A; PSMD6; SKP1; PSMB1; PSMC2; PSMD13; UBC; PSME2; PSMA3; PSMA4; PSMD7; PSMB6; PSMB3; PSMC5; PSMA7; UBA52; PSMD8; PSMC4
R-HSA-453276	Regulation of mitotic cell cycle	3.65	1.13e-07	9.12e-07	20/57	PSMA5; PSMD4; RPS27A; PSMD6; SKP1; PSMB1; PSMC2; PSMD13; UBC; PSME2; PSMA3; PSMA4; PSMD7; PSMB6; PSMB3; PSMC5; PSMA7; UBA52; PSMD8; PSMC4
R-HSA-1234174	Regulation of Hypoxia-inducible Factor (HIF) by oxygen	3.65	1.13e-07	9.12e-07	20/57	PSMA5; PSMD4; RPS27A; PSMD6; PSMB1; PSMC2; TCEB1; PSMD13; UBC; PSME2; PSMA3; PSMA4; PSMD7; PSMB6; PSMB3; PSMC5; PSMA7; UBA52; PSMD8; PSMC4
R-HSA-2262749	Cellular response to hypoxia	3.65	1.13e-07	9.12e-07	20/57	PSMA5; PSMD4; RPS27A; PSMD6; PSMB1; PSMC2; TCEB1; PSMD13; UBC; PSME2; PSMA3; PSMA4; PSMD7; PSMB6; PSMB3; PSMC5; PSMA7; UBA52; PSMD8; PSMC4
R-HSA-72766	Translation	3.65	0.00e+00	0.00e+00	90/257	RPL22; DDOST; RPL11; RPS8; RPL5; RPS27; SRP9; RPS7; RPS27A; RPL31; RPL37A; RPL32; RPL15; RPSA; RPL14; RPL29; RPL24; EIF4A2; RPL35A; RPL9; RPL34; RPS3A; RPL37; RPS23; RPS14; RPS18; RPS10; RPL10A; RPS12; RPS4X; RPL36A; RPL39; SSR4; RPL10; RPS20; RPL7; RPL30; PABPC1; RPL8; RPS6; RPL35; RPL12; RPL7A; RPLP2; RPL27A; RPS13; SPCS2; RPS3; RPS25; PPA1; RPS24; RPL41; RPL6; RPLP0; RPL21; RPS29; SRP14; RPL4; RPLP1; RPS17; RPS2; RPS15A; TUFM; RPL13; EIF4A1; RPL26; RPL23A; RPL23; RPL19; RPL27; RPL38; SEC11C; RPN2; RPS21; RPS15; EEF2; RPL36; RPS28; RPL18A; UBA52; RPS16; RPS19; RPL18; RPL13A; RPS11; RPS9; RPL28; RPS5; RPL3; MRPS6
R-HSA-162588	Budding and maturation of HIV virion	3.64	1.82e-03	7.97e-03	7/20	RPS27A; PPIA; CHMP5; TSG101; UBC; UBA52; CHMP2A
R-HSA-114608	Platelet degranulation	3.63	5.00e-06	2.91e-05	15/43	TAGLN2; CALM2; TUBA4A; PPIA; MAGED2; CFL1; APLP2; PSAP; CD63; CALM1; SCG3; ALDOA; LGALS3BP; CALM3; SOD1
R-HSA-76005	Response to elevated platelet cytosolic Ca2+	3.63	5.00e-06	2.91e-05	15/43	TAGLN2; CALM2; TUBA4A; PPIA; MAGED2; CFL1; APLP2; PSAP; CD63; CALM1; SCG3; ALDOA; LGALS3BP; CALM3; SOD1
R-HSA-5619115	Disorders of transmembrane transporters	3.60	3.16e-07	2.14e-06	19/55	PSMA5; PSMD4; RPS27A; PSMD6; PSMB1; PSMC2; PSMD13; UBC; PSME2; PSMA3; PSMA4; PSMD7; PSMB6; PSMB3; PSMC5; PSMA7; UBA52; PSMD8; PSMC4
R-HSA-176409	APC/C:Cdc20 mediated degradation of mitotic proteins	3.60	3.16e-07	2.14e-06	19/55	PSMA5; PSMD4; RPS27A; PSMD6; PSMB1; PSMC2; PSMD13; UBC; PSME2; PSMA3; PSMA4; PSMD7; PSMB6; PSMB3; PSMC5; PSMA7; UBA52; PSMD8; PSMC4
R-HSA-176814	Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins	3.60	3.16e-07	2.14e-06	19/55	PSMA5; PSMD4; RPS27A; PSMD6; PSMB1; PSMC2; PSMD13; UBC; PSME2; PSMA3; PSMA4; PSMD7; PSMB6; PSMB3; PSMC5; PSMA7; UBA52; PSMD8; PSMC4
R-HSA-382556	ABC-family proteins mediated transport	3.53	4.36e-07	2.87e-06	19/56	PSMA5; PSMD4; RPS27A; PSMD6; PSMB1; PSMC2; PSMD13; UBC; PSME2; PSMA3; PSMA4; PSMD7; PSMB6; PSMB3; PSMC5; PSMA7; UBA52; PSMD8; PSMC4
R-HSA-8878159	Transcriptional regulation by RUNX3	3.53	2.18e-07	1.63e-06	20/59	PSMA5; PSMD4; RPS27A; CTNNB1; PSMD6; PSMB1; PSMC2; PSMD13; UBC; PSME2; PSMA3; PSMA4; PSMD7; PSMB6; PSMB3; PSMC5; PSMA7; UBA52; PSMD8; PSMC4
R-HSA-69052	Switching of origins to a post-replicative state	3.53	2.18e-07	1.63e-06	20/59	PSMA5; PSMD4; RPS27A; PSMD6; SKP1; PSMB1; PSMC2; PSMD13; UBC; PSME2; PSMA3; PSMA4; PSMD7; PSMB6; PSMB3; PSMC5; PSMA7; UBA52; PSMD8; PSMC4
R-HSA-195253	Degradation of beta-catenin by the destruction complex	3.53	1.09e-07	9.12e-07	21/62	PSMA5; PSMD4; RPS27A; CTNNB1; PSMD6; SKP1; PSMB1; PSMC2; PSMD13; UBC; PSME2; PSMA3; PSMA4; PSMD7; PSMB6; PSMB3; PSMC5; PSMA7; UBA52; PSMD8; PSMC4
R-HSA-450531	Regulation of mRNA stability by proteins that bind AU-rich elements	3.52	2.72e-08	2.82e-07	23/68	PSMA5; PSMD4; RPS27A; PSMD6; PSMB1; PSMC2; PABPC1; SET; PSMD13; HSPA8; UBC; PSME2; PSMA3; PSMA4; PSMD7; PSMB6; PSMB3; PSMC5; YWHAB; PSMA7; UBA52; PSMD8; PSMC4
R-HSA-4086400	PCP/CE pathway	3.47	1.50e-07	1.18e-06	21/63	PSMA5; PSMD4; RPS27A; PSMD6; AP2M1; PSMB1; PSMC2; CLTA; PSMD13; UBC; PSME2; PSMA3; PSMA4; PSMD7; PSMB6; PSMB3; PSMC5; PSMA7; UBA52; PSMD8; PSMC4
R-HSA-8939236	RUNX1 regulates transcription of genes involved in differentiation of HSCs	3.47	2.99e-07	2.08e-06	20/60	PSMA5; PSMD4; H3F3A; RPS27A; PSMD6; PSMB1; PSMC2; PSMD13; UBC; PSME2; PSMA3; PSMA4; PSMD7; PSMB6; PSMB3; PSMC5; PSMA7; UBA52; PSMD8; PSMC4
R-HSA-191273	Cholesterol biosynthesis	3.47	2.51e-03	1.06e-02	7/21	FDPS; ACAT2; EBP; NSDHL; FDFT1; TM7SF2; DHCR7
R-HSA-5205685	Pink/Parkin Mediated Mitophagy	3.47	1.06e-02	3.95e-02	5/15	RPS27A; VDAC1; UBC; MAP1LC3B; UBA52
R-HSA-168643	Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways	3.47	1.06e-02	3.95e-02	5/15	RPS27A; HSP90AB1; TXN; UBC; UBA52
R-HSA-5627123	RHO GTPases activate PAKs	3.47	5.14e-03	2.02e-02	6/18	CDC42; CALM2; MYL6; CALM1; MYL12B; CALM3
R-HSA-5358351	Signaling by Hedgehog	3.43	3.12e-09	4.89e-08	27/82	PSMA5; PSMD4; RPS27A; TUBA4A; PSMD6; SKP1; TUBB2A; TUBB2B; PSMB1; PSMC2; TUBB4B; PSMD13; TUBA1B; TUBA1A; UBC; PSME2; PSMA3; PSMA4; PSMD7; TUBB3; PSMB6; PSMB3; PSMC5; PSMA7; UBA52; PSMD8; PSMC4
R-HSA-202403	TCR signaling	3.41	4.06e-07	2.69e-06	20/61	PSMA5; PSMD4; RPS27A; PSMD6; SKP1; PSMB1; PSMC2; PSMD13; UBC; PSME2; PSMA3; PSMA4; PSMD7; PSMB6; PSMB3; PSMC5; PSMA7; UBA52; PSMD8; PSMC4
R-HSA-5621481	C-type lectin receptors (CLRs)	3.37	6.85e-08	6.56e-07	23/71	PSMA5; PSMD4; CALM2; RPS27A; PSMD6; SKP1; PSMB1; PSMC2; PSMD13; UBC; PSME2; PSMA3; CALM1; PSMA4; PSMD7; PSMB6; PSMB3; PSMC5; PSMA7; UBA52; PSMD8; PSMC4; CALM3
R-HSA-5687128	MAPK6/MAPK4 signaling	3.36	2.74e-07	1.94e-06	21/65	CDC42; PSMA5; PSMD4; RPS27A; PSMD6; PSMB1; SEPT7; PSMC2; PSMD13; UBC; PSME2; PSMA3; PSMA4; PSMD7; PSMB6; PSMB3; PSMC5; PSMA7; UBA52; PSMD8; PSMC4
R-HSA-8950505	Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation	3.35	8.29e-04	3.96e-03	9/28	CDC42; HNRNPA2B1; RALA; PPIA; TALDO1; CFL1; RPLP0; PSME2; SOD1
R-HSA-446652	Interleukin-1 family signaling	3.31	3.67e-07	2.45e-06	21/66	PSMA5; PSMD4; RPS27A; PSMD6; SKP1; PSMB1; PSMC2; PSMD13; UBC; HMGB1; PSME2; PSMA3; PSMA4; PSMD7; PSMB6; PSMB3; PSMC5; PSMA7; UBA52; PSMD8; PSMC4
R-HSA-5689603	UCH proteinases	3.17	8.48e-07	5.33e-06	21/69	PSMA5; PSMD4; RPS27A; PSMD6; UCHL1; PSMB1; ACTB; PSMC2; PSMD13; UBC; PSME2; PSMA3; PSMA4; PSMD7; PSMB6; PSMB3; PSMC5; PSMA7; UBA52; PSMD8; PSMC4
R-HSA-983189	Kinesins	3.17	4.48e-03	1.78e-02	7/23	TUBA4A; TUBB2A; TUBB2B; TUBB4B; TUBA1B; TUBA1A; TUBB3
R-HSA-351202	Metabolism of polyamines	3.16	1.01e-05	5.63e-05	17/56	PSMA5; PSMD4; PSMD6; PSMB1; PSMC2; PSMD13; PSME2; PSMA3; CKB; PSMA4; PSMD7; PSMB6; PSMB3; PSMC5; PSMA7; PSMD8; PSMC4
R-HSA-8878166	Transcriptional regulation by RUNX2	3.15	1.68e-06	1.03e-05	20/66	PSMA5; PSMD4; RPS27A; PSMD6; SKP1; PSMB1; PSMC2; PSMD13; UBC; PSME2; PSMA3; PSMA4; PSMD7; PSMB6; PSMB3; PSMC5; PSMA7; UBA52; PSMD8; PSMC4
R-HSA-69239	Synthesis of DNA	3.15	1.68e-06	1.03e-05	20/66	PSMA5; PSMD4; RPS27A; PSMD6; SKP1; PSMB1; PSMC2; PSMD13; UBC; PSME2; PSMA3; PSMA4; PSMD7; PSMB6; PSMB3; PSMC5; PSMA7; UBA52; PSMD8; PSMC4
R-HSA-9020591	Interleukin-12 signaling	3.12	1.44e-03	6.47e-03	9/30	CDC42; HNRNPA2B1; RALA; PPIA; TALDO1; CFL1; RPLP0; PSME2; SOD1
R-HSA-5205647	Mitophagy	3.12	9.09e-03	3.46e-02	6/20	RPS27A; VDAC1; CSNK2B; UBC; MAP1LC3B; UBA52
R-HSA-3928662	EPHB-mediated forward signaling	3.08	2.89e-03	1.21e-02	8/27	CDC42; ARPC5; ARPC2; ACTB; ARPC1A; CFL1; ARPC3; ACTG1
R-HSA-69481	G2/M Checkpoints	3.07	4.73e-07	3.08e-06	23/78	PSMA5; PSMD4; YWHAQ; RPS27A; SUMO1; PSMD6; PSMB1; PSMC2; PSMD13; UBC; PSME2; PSMA3; PSMA4; PSMD7; YWHAE; PSMB6; PSMB3; PSMC5; YWHAB; PSMA7; UBA52; PSMD8; PSMC4
R-HSA-2454202	Fc epsilon receptor (FCERI) signaling	3.03	6.09e-07	3.89e-06	23/79	PSMA5; PSMD4; CALM2; RPS27A; PSMD6; SKP1; PSMB1; PSMC2; PSMD13; UBC; PSME2; PSMA3; CALM1; PSMA4; PSMD7; PSMB6; PSMB3; PSMC5; PSMA7; UBA52; PSMD8; PSMC4; CALM3
R-HSA-3858494	Beta-catenin independent WNT signaling	3.03	2.00e-07	1.54e-06	25/86	PSMA5; PSMD4; CALM2; RPS27A; CTNNB1; PSMD6; AP2M1; PSMB1; PSMC2; CLTA; PSMD13; UBC; PSME2; PSMA3; CALM1; PSMA4; PSMD7; PSMB6; PSMB3; PSMC5; PSMA7; UBA52; PSMD8; PSMC4; CALM3
R-HSA-69306	DNA Replication	3.02	3.65e-06	2.17e-05	20/69	PSMA5; PSMD4; RPS27A; PSMD6; SKP1; PSMB1; PSMC2; PSMD13; UBC; PSME2; PSMA3; PSMA4; PSMD7; PSMB6; PSMB3; PSMC5; PSMA7; UBA52; PSMD8; PSMC4
R-HSA-211859	Biological oxidations	2.97	3.93e-04	1.96e-03	12/42	AKR7A2; GSTM3; MGST3; EPHX1; PODXL2; HSP90AB1; GSTA4; GSTP1; PTGES3; ALDH2; ESD; CYB5R3
R-HSA-1266738	Developmental Biology	2.95	0.00e+00	0.00e+00	126/445	RPL22; CDC42; RPL11; RPS8; RPL5; PSMA5; PSMD4; RPS27; ARPC5; H3F3A; RPS7; RPS27A; RPL31; NEUROD1; RPL37A; ARPC2; TUBA4A; RPL32; RPL15; RPSA; RPL14; CTNNB1; RPL29; PSMD6; RPL24; GAP43; AP2M1; RPL35A; RPL9; RPL34; RPS3A; RPL37; RPS23; RPS14; TUBB2A; TUBB2B; CSNK2B; RPS18; RPS10; RPL10A; HSP90AB1; RPS12; PSMB1; ACTB; ARPC1A; PSMC2; RPS4X; RPL36A; RPL39; RPL10; RPS20; SDCBP; RPL7; TCEB1; RPL30; PABPC1; RPL8; RPS6; CLTA; RPL35; RPL12; RPL7A; TUBB4B; PSMD13; RPLP2; RPL27A; RPS13; CFL1; RPS3; RPS25; HSPA8; RPS24; TUBA1B; TUBA1A; RPL41; MYL6; ARPC3; RPL6; RPLP0; MSI1; UBC; RPL21; PSME2; RPS29; PSMA3; HSP90AA1; RPL4; RPLP1; PSMA4; RPS17; RPS2; RPS15A; PSMD7; RPL13; TUBB3; PSMB6; RPL26; RPL23A; PSMB3; RPL23; RPL19; RPL27; PSMC5; RPL38; EIF4A3; ACTG1; MYL12B; PSMA7; RPS21; RPS15; RPL36; RPS28; RPL18A; UBA52; PSENEN; PSMD8; RPS16; PSMC4; RPS19; RPL18; RPL13A; RPS11; RPS9; RPL28; RPS5; RPL3
R-HSA-69206	G1/S Transition	2.93	5.93e-06	3.38e-05	20/71	PSMA5; PSMD4; RPS27A; PSMD6; SKP1; PSMB1; PSMC2; PSMD13; UBC; PSME2; PSMA3; PSMA4; PSMD7; PSMB6; PSMB3; PSMC5; PSMA7; UBA52; PSMD8; PSMC4
R-HSA-447115	Interleukin-12 family signaling	2.93	2.38e-03	1.01e-02	9/32	CDC42; HNRNPA2B1; RALA; PPIA; TALDO1; CFL1; RPLP0; PSME2; SOD1
R-HSA-69275	G2/M Transition	2.90	3.77e-09	5.41e-08	34/122	PSMA5; PSMD4; RPS27A; TUBA4A; PSMD6; SKP1; TUBB2A; TUBB2B; TUBB; HSP90AB1; PSMB1; PSMC2; DCTN3; TUBB4B; PSMD13; TUBA1B; TUBA1A; DCTN2; DYNLL1; UBC; PSME2; PSMA3; HSP90AA1; PSMA4; PSMD7; TUBB3; YWHAE; PSMB6; PSMB3; PSMC5; PSMA7; UBA52; PSMD8; PSMC4
R-HSA-453274	Mitotic G2-G2/M phases	2.88	4.76e-09	6.40e-08	34/123	PSMA5; PSMD4; RPS27A; TUBA4A; PSMD6; SKP1; TUBB2A; TUBB2B; TUBB; HSP90AB1; PSMB1; PSMC2; DCTN3; TUBB4B; PSMD13; TUBA1B; TUBA1A; DCTN2; DYNLL1; UBC; PSME2; PSMA3; HSP90AA1; PSMA4; PSMD7; TUBB3; YWHAE; PSMB6; PSMB3; PSMC5; PSMA7; UBA52; PSMD8; PSMC4
R-HSA-453279	Mitotic G1-G1/S phases	2.88	4.84e-06	2.86e-05	21/76	PSMA5; PSMD4; RPS27A; PSMD6; SKP1; PSMB1; PSMC2; PSMD13; UBC; PSME2; PSMA3; PSMA4; PSMD7; PSMB6; PSMB3; PSMC5; PSMA7; CDKN2D; UBA52; PSMD8; PSMC4
R-HSA-71406	Pyruvate metabolism and Citric Acid (TCA) cycle	2.84	3.00e-03	1.25e-02	9/33	SUCLG1; PDHB; VDAC1; MDH2; PDHA1; LDHA; LDHB; IDH2; BSG
R-HSA-109581	Apoptosis	2.84	2.72e-07	1.94e-06	27/99	PSMA5; PSMD4; YWHAQ; RPS27A; CTNNB1; PSMD6; PSMB1; CYCS; PSMC2; BCAP31; PSMD13; DYNLL1; UBC; HMGB1; PSME2; PSMA3; PSMA4; PSMD7; YWHAE; PSMB6; PSMB3; PSMC5; YWHAB; PSMA7; UBA52; PSMD8; PSMC4
R-HSA-5357801	Programmed Cell Death	2.84	2.72e-07	1.94e-06	27/99	PSMA5; PSMD4; YWHAQ; RPS27A; CTNNB1; PSMD6; PSMB1; CYCS; PSMC2; BCAP31; PSMD13; DYNLL1; UBC; HMGB1; PSME2; PSMA3; PSMA4; PSMD7; YWHAE; PSMB6; PSMB3; PSMC5; YWHAB; PSMA7; UBA52; PSMD8; PSMC4
R-HSA-162909	Host Interactions of HIV factors	2.83	8.29e-07	5.25e-06	25/92	PSMA5; PSMD4; RPS27A; PSMD6; AP2M1; SLC25A4; SKP1; PSMB1; PPIA; PSMC2; TCEB1; PSMD13; UBC; RAN; PSME2; PSMA3; PSMA4; PSMD7; PSMB6; PSMB3; PSMC5; PSMA7; UBA52; PSMD8; PSMC4
R-HSA-2029482	Regulation of actin dynamics for phagocytic cup formation	2.81	1.92e-03	8.25e-03	10/37	CDC42; ARPC5; ARPC2; HSP90AB1; ACTB; ARPC1A; CFL1; ARPC3; HSP90AA1; ACTG1
R-HSA-5663213	RHO GTPases Activate WASPs and WAVEs	2.80	9.34e-03	3.53e-02	7/26	CDC42; ARPC5; ARPC2; ACTB; ARPC1A; ARPC3; ACTG1
R-HSA-5620924	Intraflagellar transport	2.78	5.90e-03	2.30e-02	8/30	TUBA4A; TUBB2A; TUBB2B; TUBB4B; TUBA1B; TUBA1A; DYNLL1; TUBB3
R-HSA-2467813	Separation of Sister Chromatids	2.74	1.37e-07	1.09e-06	30/114	NUDC; PSMA5; PSMD4; RPS27; RPS27A; TUBA4A; PSMD6; TUBB2A; TUBB2B; PSMB1; PSMC2; TUBB4B; PSMD13; SMC3; TUBA1B; TUBA1A; DYNLL1; UBC; PSME2; PSMA3; PSMA4; PSMD7; TUBB3; PSMB6; PSMB3; PSMC5; PSMA7; UBA52; PSMD8; PSMC4
R-HSA-1643685	Disease	2.71	0.00e+00	0.00e+00	121/464	RPL22; RPL11; RPS8; PRDX1; RPL5; PSMA5; PSMD4; RPS27; RPS7; CALM2; RPS27A; RPL31; RPL37A; RPL32; RPL15; RPSA; RPL14; CTNNB1; RPL29; PSMD6; RPL24; AP2M1; RPL35A; RPL9; RPL34; RPS3A; SLC25A4; RPL37; RPS23; SKP1; RPS14; RPS18; RPS10; RPL10A; HSP90AB1; RPS12; PSMB1; ACTB; PPIA; PSMC2; RPS4X; RPL36A; RPL39; RPL10; RPS20; RPL7; TCEB1; RPL30; RPL8; RPS6; CHMP5; CLTA; RPL35; RPL12; RPL7A; PSMD13; TALDO1; RPLP2; RPL27A; RPS13; TSG101; RPS3; RPS25; RPS24; RPL41; RPL6; PEBP1; RPLP0; UBC; RAN; RPL21; PSME2; RPS29; PSMA3; CALM1; HSP90AA1; RPL4; RPLP1; PSMA4; RPS17; RPS2; RPS15A; PSMD7; RPL13; YWHAE; PSMB6; RPL26; RPL23A; PSMB3; RPL23; RPL19; RPL27; G6PC3; PSMC5; KPNA2; RPL38; ACTG1; YWHAB; PSMA7; RPS21; RPS15; EEF2; RPL36; RPS28; PRDX2; RPL18A; UBA52; PSENEN; PSMD8; RPS16; PSMC4; RPS19; CALM3; RPL18; RPL13A; RPS11; RPS9; RPL28; RPS5; CHMP2A; RPL3
R-HSA-977225	Amyloid fiber formation	2.70	1.16e-02	4.25e-02	7/27	H3F3A; RPS27A; UBC; ITM2B; CST3; UBA52; PSENEN
R-HSA-917937	Iron uptake and transport	2.69	7.31e-03	2.81e-02	8/31	ATP6V0B; RPS27A; SKP1; ATP6AP1; UBC; ATP6V0D1; UBA52; FTL
R-HSA-2029480	Fcgamma receptor (FCGR) dependent phagocytosis	2.66	1.87e-03	8.10e-03	11/43	CDC42; ARPC5; ARPC2; HSP90AB1; ACTB; ARPC1A; CFL1; ARPC3; HSP90AA1; ACTG1; PLD3
R-HSA-2682334	EPH-Ephrin signaling	2.65	4.89e-04	2.39e-03	14/55	CDC42; ARPC5; ARPC2; AP2M1; ACTB; ARPC1A; SDCBP; CLTA; CFL1; MYL6; ARPC3; ACTG1; MYL12B; PSENEN
R-HSA-2555396	Mitotic Metaphase and Anaphase	2.58	5.68e-07	3.65e-06	30/121	NUDC; PSMA5; PSMD4; RPS27; RPS27A; TUBA4A; PSMD6; TUBB2A; TUBB2B; PSMB1; PSMC2; TUBB4B; PSMD13; SMC3; TUBA1B; TUBA1A; DYNLL1; UBC; PSME2; PSMA3; PSMA4; PSMD7; TUBB3; PSMB6; PSMB3; PSMC5; PSMA7; UBA52; PSMD8; PSMC4
R-HSA-68882	Mitotic Anaphase	2.58	5.68e-07	3.65e-06	30/121	NUDC; PSMA5; PSMD4; RPS27; RPS27A; TUBA4A; PSMD6; TUBB2A; TUBB2B; PSMB1; PSMC2; TUBB4B; PSMD13; SMC3; TUBA1B; TUBA1A; DYNLL1; UBC; PSME2; PSMA3; PSMA4; PSMD7; TUBB3; PSMB6; PSMB3; PSMC5; PSMA7; UBA52; PSMD8; PSMC4
R-HSA-5673001	RAF/MAP kinase cascade	2.48	7.23e-06	4.10e-05	26/109	PSMA5; PSMD4; CALM2; RPS27A; PSMD6; PSMB1; ACTB; PSMC2; PSMD13; PEBP1; UBC; PSME2; PSMA3; CALM1; PSMA4; PSMD7; PSMB6; PSMB3; PSMC5; ACTG1; YWHAB; PSMA7; UBA52; PSMD8; PSMC4; CALM3
R-HSA-5684996	MAPK1/MAPK3 signaling	2.46	8.65e-06	4.87e-05	26/110	PSMA5; PSMD4; CALM2; RPS27A; PSMD6; PSMB1; ACTB; PSMC2; PSMD13; PEBP1; UBC; PSME2; PSMA3; CALM1; PSMA4; PSMD7; PSMB6; PSMB3; PSMC5; ACTG1; YWHAB; PSMA7; UBA52; PSMD8; PSMC4; CALM3
R-HSA-2565942	Regulation of PLK1 Activity at G2/M Transition	2.46	1.63e-03	7.20e-03	13/55	RPS27A; TUBA4A; SKP1; TUBB; DCTN3; TUBB4B; TUBA1A; DCTN2; DYNLL1; UBC; HSP90AA1; YWHAE; UBA52
R-HSA-380320	Recruitment of NuMA to mitotic centrosomes	2.46	1.63e-03	7.20e-03	13/55	TUBA4A; TUBB2A; TUBB2B; TUBB; DCTN3; TUBB4B; TUBA1B; TUBA1A; DCTN2; DYNLL1; HSP90AA1; TUBB3; YWHAE
R-HSA-70326	Glucose metabolism	2.44	3.99e-03	1.61e-02	11/47	ENO1; MDH1; MDH2; PGK1; PGAM1; GAPDH; TPI1; PKM; ALDOA; ENO3; G6PC3
R-HSA-69242	S Phase	2.43	7.96e-05	4.16e-04	21/90	PSMA5; PSMD4; RPS27A; PSMD6; SKP1; PSMB1; PSMC2; PSMD13; SMC3; UBC; PSME2; PSMA3; PSMA4; PSMD7; PSMB6; PSMB3; PSMC5; PSMA7; UBA52; PSMD8; PSMC4
R-HSA-5689880	Ub-specific processing proteases	2.42	3.91e-05	2.08e-04	23/99	PSMA5; PSMD4; RPS27A; PSMD6; VDAC1; PSMB1; PSMC2; VDAC3; PSMD13; VDAC2; UBC; PSME2; PSMA3; PSMA4; PSMD7; PSMB6; PSMB3; PSMC5; PSMA7; UBA52; PSMD8; PSMC4; UFD1L
R-HSA-6807878	COPI-mediated anterograde transport	2.41	6.11e-04	2.97e-03	16/69	CAPZB; RAB1A; TUBA4A; ARF4; TUBB2A; TUBB2B; DCTN3; TUBB4B; TUBA1B; TUBA1A; DCTN2; DYNLL1; ACTR10; TUBB3; COPE; NAPA
R-HSA-2132295	MHC class II antigen presentation	2.40	9.51e-04	4.40e-03	15/65	CAPZB; TUBA4A; RAB7A; AP2M1; TUBB2A; TUBB2B; DCTN3; CLTA; TUBB4B; TUBA1B; TUBA1A; DCTN2; DYNLL1; ACTR10; TUBB3
R-HSA-390466	Chaperonin-mediated protein folding	2.36	3.59e-03	1.47e-02	12/53	CCT7; TUBA4A; CCT5; TUBB2A; TUBB2B; CSNK2B; ACTB; TUBB4B; TUBA1B; TUBA1A; CCT2; TUBB3
R-HSA-391251	Protein folding	2.33	2.72e-03	1.14e-02	13/58	CCT7; TUBA4A; CCT5; TUBB2A; TUBB2B; CSNK2B; ACTB; TUBB4B; TUBA1B; TUBA1A; CCT2; TUBB3; TBCB
R-HSA-373760	L1CAM interactions	2.30	1.56e-03	6.94e-03	15/68	TUBA4A; GAP43; AP2M1; TUBB2A; TUBB2B; CSNK2B; ACTB; SDCBP; CLTA; TUBB4B; HSPA8; TUBA1B; TUBA1A; TUBB3; ACTG1
R-HSA-201681	TCF dependent signaling in response to WNT	2.29	1.38e-04	7.07e-04	22/100	PSMA5; PSMD4; H3F3A; RPS27A; CTNNB1; PSMD6; CSNK2B; PSMB1; PSMC2; PSMD13; UBC; PSME2; PSMA3; PSMA4; PSMD7; PSMB6; PSMB3; PSMC5; PSMA7; UBA52; PSMD8; PSMC4
R-HSA-1592230	Mitochondrial biogenesis	2.22	4.34e-03	1.73e-02	13/61	ATP5F1; CALM2; ATP5G3; CYCS; SSBP1; ATP5C1; ATP5B; CALM1; IDH2; ATP5A1; CALM3; ATP5J; ATP5O
R-HSA-6798695	Neutrophil degranulation	2.19	1.06e-06	6.54e-06	39/185	DDOST; PSMA5; ILF2; ARPC5; PSMD6; RAB7A; TUBB; CSNK2B; HSP90AB1; DYNLT1; PSMB1; PPIA; PSMC2; PRDX4; ATP6AP2; SDCBP; GGH; TUBB4B; PSMD13; GSTP1; NDUFC2; HSPA8; PSAP; PGAM1; CD63; CCT2; DYNLL1; HMGB1; ACTR10; HSP90AA1; SRP14; PKM; ALDOA; PSMD7; VAPA; CST3; EEF2; FTL; CYB5R3
R-HSA-5683057	MAPK family signaling cascades	2.19	3.96e-05	2.09e-04	28/133	CDC42; PSMA5; PSMD4; CALM2; RPS27A; PSMD6; PSMB1; ACTB; SEPT7; PSMC2; PSMD13; PEBP1; UBC; PSME2; PSMA3; CALM1; PSMA4; PSMD7; PSMB6; PSMB3; PSMC5; ACTG1; YWHAB; PSMA7; UBA52; PSMD8; PSMC4; CALM3
R-HSA-1428517	The citric acid (TCA) cycle and respiratory electron transport	2.18	2.23e-05	1.21e-04	30/143	ATP5F1; SUCLG1; ATP5G3; UQCRC1; PDHB; VDAC1; NDUFA4; CYCS; MDH2; PDHA1; NDUFB11; COX6C; NDUFB6; LDHA; NDUFV1; NDUFC2; ATP5C1; NDUFB8; LDHB; ATP5B; COX5A; IDH2; UQCRC2; NDUFV2; ATP5A1; BSG; NDUFA13; ETFB; ATP5J; ATP5O
R-HSA-2262752	Cellular responses to stress	2.18	4.60e-08	4.55e-07	49/234	CAPZB; PRDX1; PSMA5; PSMD4; H3F3A; RPS27A; TUBA4A; PSMD6; TUBB2A; TUBB2B; HSP90AB1; PSMB1; CYCS; PSMC2; TCEB1; DNAJA1; DCTN3; TXN; TUBB4B; PSMD13; PRDX5; GSTP1; C11orf73; HSPA8; TUBA1B; TUBA1A; PTGES3; DCTN2; DYNLL1; UBC; PSME2; ACTR10; PSMA3; HSP90AA1; PSMA4; PSMD7; TERF2IP; TUBB3; YWHAE; PSMB6; PSMB3; PSMC5; PSMA7; CDKN2D; PRDX2; UBA52; PSMD8; PSMC4; SOD1
R-HSA-449147	Signaling by Interleukins	2.18	1.25e-05	6.92e-05	32/153	CDC42; PSMA5; PSMD4; RPS27A; PSMD6; SKP1; PSMB1; HNRNPA2B1; RALA; PPIA; PSMC2; PSMD13; TALDO1; CFL1; HSPA8; HSP90B1; RPLP0; UBC; HMGB1; PSME2; PSMA3; HSP90AA1; PSMA4; PSMD7; PSMB6; PSMB3; PSMC5; PSMA7; UBA52; PSMD8; PSMC4; SOD1
R-HSA-8878171	Transcriptional regulation by RUNX1	2.14	3.86e-04	1.93e-03	22/107	PSMA5; PSMD4; H3F3A; RPS27A; PSMD6; CSNK2B; PSMB1; PSMC2; PSMD13; UBC; PSME2; PSMA3; PSMA4; PSMD7; PSMB6; PSMB3; PSMC5; PSMA7; UBA52; PSMD8; PSMC4; PRMT1
R-HSA-8856688	Golgi-to-ER retrograde transport	2.13	1.84e-03	8.02e-03	17/83	CAPZB; RAB1A; TUBA4A; ARF4; TUBB2A; TUBB2B; DCTN3; TUBB4B; TUBA1B; TUBA1A; DCTN2; DYNLL1; ACTR10; TUBB3; COPE; PAFAH1B3; NAPA
R-HSA-157118	Signaling by NOTCH	2.12	4.43e-04	2.18e-03	22/108	PSMA5; PSMD4; H3F3A; RPS27A; PSMD6; SKP1; PSMB1; PSMC2; PSMD13; UBC; PSME2; PSMA3; PSMA4; PSMD7; PSMB6; PSMB3; PSMC5; PSMA7; UBA52; PSENEN; PSMD8; PSMC4
R-HSA-983231	Factors involved in megakaryocyte development and platelet production	2.12	1.19e-02	4.33e-02	11/54	CAPZB; CDC42; H3F3A; TUBA4A; TUBB2A; TUBB2B; ACTB; TUBB4B; TUBA1B; TUBA1A; TUBB3
R-HSA-6811434	COPI-dependent Golgi-to-ER retrograde traffic	2.12	1.19e-02	4.33e-02	11/54	RAB1A; TUBA4A; ARF4; TUBB2A; TUBB2B; TUBB4B; TUBA1B; TUBA1A; TUBB3; COPE; NAPA
R-HSA-71387	Metabolism of carbohydrates	2.10	8.98e-04	4.20e-03	20/99	ENO1; CALM2; RPS27A; MDH1; TKT; MDH2; AKR1B1; PGK1; TALDO1; PGAM1; GAPDH; TPI1; UBC; CALM1; PKM; ALDOA; ENO3; G6PC3; UBA52; CALM3
R-HSA-6807070	PTEN Regulation	2.08	7.71e-04	3.71e-03	21/105	PSMA5; PSMD4; RPS27A; PSMD6; CSNK2B; PSMB1; PSMC2; RRAGA; PSMD13; UBC; PSME2; PSMA3; PSMA4; PSMD7; PSMB6; PSMB3; PSMC5; PSMA7; UBA52; PSMD8; PSMC4
R-HSA-8856828	Clathrin-mediated endocytosis	2.05	4.89e-03	1.93e-02	15/76	ARPC5; RPS27A; ARPC2; COPS8; AP2M1; ACTB; ARPC1A; COPS6; CLTA; HSPA8; ARPC3; UBC; COPS3; ACTG1; UBA52
R-HSA-68886	M Phase	2.04	5.30e-06	3.06e-05	40/204	NUDC; PSMA5; PSMD4; RPS27; H3F3A; RPS27A; RAB1A; TUBA4A; PSMD6; TUBB2A; TUBB2B; TUBB; CSNK2B; PSMB1; PSMC2; RAB2A; DCTN3; SET; TUBB4B; PSMD13; SMC3; TUBA1B; TUBA1A; DCTN2; DYNLL1; UBC; PSME2; PSMA3; HSP90AA1; PSMA4; PSMD7; TUBB3; YWHAE; PSMB6; PSMB3; PSMC5; PSMA7; UBA52; PSMD8; PSMC4
R-HSA-195721	Signaling by WNT	2.03	1.30e-04	6.71e-04	29/149	PSMA5; PSMD4; H3F3A; CALM2; RPS27A; CTNNB1; PSMD6; AP2M1; SKP1; CSNK2B; PSMB1; PSMC2; CLTA; PSMD13; VPS29; UBC; PSME2; PSMA3; CALM1; PSMA4; PSMD7; PSMB6; PSMB3; PSMC5; PSMA7; UBA52; PSMD8; PSMC4; CALM3
R-HSA-195258	RHO GTPase Effectors	2.02	1.73e-04	8.83e-04	28/144	CDC42; NUDC; RPS27; ARPC5; H3F3A; YWHAQ; CALM2; ARPC2; TUBA4A; CTNNB1; TUBB2A; TUBB2B; ACTB; ARPC1A; TUBB4B; CFL1; TUBA1B; TUBA1A; MYL6; ARPC3; DYNLL1; CALM1; TUBB3; YWHAE; ACTG1; MYL12B; YWHAB; CALM3
R-HSA-5663220	RHO GTPases Activate Formins	2.02	9.89e-03	3.72e-02	13/67	CDC42; NUDC; RPS27; TUBA4A; TUBB2A; TUBB2B; ACTB; TUBB4B; TUBA1B; TUBA1A; DYNLL1; TUBB3; ACTG1
R-HSA-8957322	Metabolism of steroids	2.01	1.32e-02	4.78e-02	12/62	FDPS; HSD17B11; ACAT2; AKR1B1; EBP; NSDHL; FDFT1; TM7SF2; DHCR7; AKR1C1; RAN; SUMO2

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Factor 3 : 33 significant Reactome pathways

GeneSet	description	enrichRatio	pValue	FDR	GeneRatio	geneSymbols
R-HSA-192823	Viral mRNA Translation	40.80	0	0	66/83	RPL11; RPS8; RPL5; RPS27; RPS7; RPS27A; RPL31; RPL37A; RPL32; RPL15; RPL14; RPL29; RPL24; RPL35A; RPL9; RPL34; RPS3A; RPL37; RPS23; RPS14; RPS18; RPL10A; RPS12; RPS4X; RPL36A; RPL39; RPL10; RPS20; RPL7; RPL30; RPS6; RPL35; RPL12; RPL7A; RPLP2; RPL27A; RPS13; RPS3; RPS25; RPS24; RPL41; RPL6; RPLP0; RPL21; RPLP1; RPS17; RPS15A; RPL13; RPL26; RPL23; RPL19; RPL38; RPS21; RPS15; RPL36; RPS28; RPL18A; RPS16; RPS19; RPL18; RPL13A; RPS11; RPS9; RPL28; RPS5; RPL3
R-HSA-156902	Peptide chain elongation	40.30	0	0	66/84	RPL11; RPS8; RPL5; RPS27; RPS7; RPS27A; RPL31; RPL37A; RPL32; RPL15; RPL14; RPL29; RPL24; RPL35A; RPL9; RPL34; RPS3A; RPL37; RPS23; RPS14; RPS18; RPL10A; RPS12; RPS4X; RPL36A; RPL39; RPL10; RPS20; RPL7; RPL30; RPS6; RPL35; RPL12; RPL7A; RPLP2; RPL27A; RPS13; RPS3; RPS25; RPS24; RPL41; RPL6; RPLP0; RPL21; RPLP1; RPS17; RPS15A; RPL13; RPL26; RPL23; RPL19; RPL38; RPS21; RPS15; RPL36; RPS28; RPL18A; RPS16; RPS19; RPL18; RPL13A; RPS11; RPS9; RPL28; RPS5; RPL3
R-HSA-2408557	Selenocysteine synthesis	39.80	0	0	66/85	RPL11; RPS8; RPL5; RPS27; RPS7; RPS27A; RPL31; RPL37A; RPL32; RPL15; RPL14; RPL29; RPL24; RPL35A; RPL9; RPL34; RPS3A; RPL37; RPS23; RPS14; RPS18; RPL10A; RPS12; RPS4X; RPL36A; RPL39; RPL10; RPS20; RPL7; RPL30; RPS6; RPL35; RPL12; RPL7A; RPLP2; RPL27A; RPS13; RPS3; RPS25; RPS24; RPL41; RPL6; RPLP0; RPL21; RPLP1; RPS17; RPS15A; RPL13; RPL26; RPL23; RPL19; RPL38; RPS21; RPS15; RPL36; RPS28; RPL18A; RPS16; RPS19; RPL18; RPL13A; RPS11; RPS9; RPL28; RPS5; RPL3
R-HSA-156842	Eukaryotic Translation Elongation	39.40	0	0	66/86	RPL11; RPS8; RPL5; RPS27; RPS7; RPS27A; RPL31; RPL37A; RPL32; RPL15; RPL14; RPL29; RPL24; RPL35A; RPL9; RPL34; RPS3A; RPL37; RPS23; RPS14; RPS18; RPL10A; RPS12; RPS4X; RPL36A; RPL39; RPL10; RPS20; RPL7; RPL30; RPS6; RPL35; RPL12; RPL7A; RPLP2; RPL27A; RPS13; RPS3; RPS25; RPS24; RPL41; RPL6; RPLP0; RPL21; RPLP1; RPS17; RPS15A; RPL13; RPL26; RPL23; RPL19; RPL38; RPS21; RPS15; RPL36; RPS28; RPL18A; RPS16; RPS19; RPL18; RPL13A; RPS11; RPS9; RPL28; RPS5; RPL3
R-HSA-72764	Eukaryotic Translation Termination	39.40	0	0	66/86	RPL11; RPS8; RPL5; RPS27; RPS7; RPS27A; RPL31; RPL37A; RPL32; RPL15; RPL14; RPL29; RPL24; RPL35A; RPL9; RPL34; RPS3A; RPL37; RPS23; RPS14; RPS18; RPL10A; RPS12; RPS4X; RPL36A; RPL39; RPL10; RPS20; RPL7; RPL30; RPS6; RPL35; RPL12; RPL7A; RPLP2; RPL27A; RPS13; RPS3; RPS25; RPS24; RPL41; RPL6; RPLP0; RPL21; RPLP1; RPS17; RPS15A; RPL13; RPL26; RPL23; RPL19; RPL38; RPS21; RPS15; RPL36; RPS28; RPL18A; RPS16; RPS19; RPL18; RPL13A; RPS11; RPS9; RPL28; RPS5; RPL3
R-HSA-975956	Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)	38.50	0	0	66/88	RPL11; RPS8; RPL5; RPS27; RPS7; RPS27A; RPL31; RPL37A; RPL32; RPL15; RPL14; RPL29; RPL24; RPL35A; RPL9; RPL34; RPS3A; RPL37; RPS23; RPS14; RPS18; RPL10A; RPS12; RPS4X; RPL36A; RPL39; RPL10; RPS20; RPL7; RPL30; RPS6; RPL35; RPL12; RPL7A; RPLP2; RPL27A; RPS13; RPS3; RPS25; RPS24; RPL41; RPL6; RPLP0; RPL21; RPLP1; RPS17; RPS15A; RPL13; RPL26; RPL23; RPL19; RPL38; RPS21; RPS15; RPL36; RPS28; RPL18A; RPS16; RPS19; RPL18; RPL13A; RPS11; RPS9; RPL28; RPS5; RPL3
R-HSA-72689	Formation of a pool of free 40S subunits	35.60	0	0	66/95	RPL11; RPS8; RPL5; RPS27; RPS7; RPS27A; RPL31; RPL37A; RPL32; RPL15; RPL14; RPL29; RPL24; RPL35A; RPL9; RPL34; RPS3A; RPL37; RPS23; RPS14; RPS18; RPL10A; RPS12; RPS4X; RPL36A; RPL39; RPL10; RPS20; RPL7; RPL30; RPS6; RPL35; RPL12; RPL7A; RPLP2; RPL27A; RPS13; RPS3; RPS25; RPS24; RPL41; RPL6; RPLP0; RPL21; RPLP1; RPS17; RPS15A; RPL13; RPL26; RPL23; RPL19; RPL38; RPS21; RPS15; RPL36; RPS28; RPL18A; RPS16; RPS19; RPL18; RPL13A; RPS11; RPS9; RPL28; RPS5; RPL3
R-HSA-2408522	Selenoamino acid metabolism	34.20	0	0	66/99	RPL11; RPS8; RPL5; RPS27; RPS7; RPS27A; RPL31; RPL37A; RPL32; RPL15; RPL14; RPL29; RPL24; RPL35A; RPL9; RPL34; RPS3A; RPL37; RPS23; RPS14; RPS18; RPL10A; RPS12; RPS4X; RPL36A; RPL39; RPL10; RPS20; RPL7; RPL30; RPS6; RPL35; RPL12; RPL7A; RPLP2; RPL27A; RPS13; RPS3; RPS25; RPS24; RPL41; RPL6; RPLP0; RPL21; RPLP1; RPS17; RPS15A; RPL13; RPL26; RPL23; RPL19; RPL38; RPS21; RPS15; RPL36; RPS28; RPL18A; RPS16; RPS19; RPL18; RPL13A; RPS11; RPS9; RPL28; RPS5; RPL3
R-HSA-1799339	SRP-dependent cotranslational protein targeting to membrane	32.50	0	0	66/104	RPL11; RPS8; RPL5; RPS27; RPS7; RPS27A; RPL31; RPL37A; RPL32; RPL15; RPL14; RPL29; RPL24; RPL35A; RPL9; RPL34; RPS3A; RPL37; RPS23; RPS14; RPS18; RPL10A; RPS12; RPS4X; RPL36A; RPL39; RPL10; RPS20; RPL7; RPL30; RPS6; RPL35; RPL12; RPL7A; RPLP2; RPL27A; RPS13; RPS3; RPS25; RPS24; RPL41; RPL6; RPLP0; RPL21; RPLP1; RPS17; RPS15A; RPL13; RPL26; RPL23; RPL19; RPL38; RPS21; RPS15; RPL36; RPS28; RPL18A; RPS16; RPS19; RPL18; RPL13A; RPS11; RPS9; RPL28; RPS5; RPL3
R-HSA-156827	L13a-mediated translational silencing of Ceruloplasmin expression	32.20	0	0	66/105	RPL11; RPS8; RPL5; RPS27; RPS7; RPS27A; RPL31; RPL37A; RPL32; RPL15; RPL14; RPL29; RPL24; RPL35A; RPL9; RPL34; RPS3A; RPL37; RPS23; RPS14; RPS18; RPL10A; RPS12; RPS4X; RPL36A; RPL39; RPL10; RPS20; RPL7; RPL30; RPS6; RPL35; RPL12; RPL7A; RPLP2; RPL27A; RPS13; RPS3; RPS25; RPS24; RPL41; RPL6; RPLP0; RPL21; RPLP1; RPS17; RPS15A; RPL13; RPL26; RPL23; RPL19; RPL38; RPS21; RPS15; RPL36; RPS28; RPL18A; RPS16; RPS19; RPL18; RPL13A; RPS11; RPS9; RPL28; RPS5; RPL3
R-HSA-927802	Nonsense-Mediated Decay (NMD)	32.20	0	0	66/105	RPL11; RPS8; RPL5; RPS27; RPS7; RPS27A; RPL31; RPL37A; RPL32; RPL15; RPL14; RPL29; RPL24; RPL35A; RPL9; RPL34; RPS3A; RPL37; RPS23; RPS14; RPS18; RPL10A; RPS12; RPS4X; RPL36A; RPL39; RPL10; RPS20; RPL7; RPL30; RPS6; RPL35; RPL12; RPL7A; RPLP2; RPL27A; RPS13; RPS3; RPS25; RPS24; RPL41; RPL6; RPLP0; RPL21; RPLP1; RPS17; RPS15A; RPL13; RPL26; RPL23; RPL19; RPL38; RPS21; RPS15; RPL36; RPS28; RPL18A; RPS16; RPS19; RPL18; RPL13A; RPS11; RPS9; RPL28; RPS5; RPL3
R-HSA-975957	Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)	32.20	0	0	66/105	RPL11; RPS8; RPL5; RPS27; RPS7; RPS27A; RPL31; RPL37A; RPL32; RPL15; RPL14; RPL29; RPL24; RPL35A; RPL9; RPL34; RPS3A; RPL37; RPS23; RPS14; RPS18; RPL10A; RPS12; RPS4X; RPL36A; RPL39; RPL10; RPS20; RPL7; RPL30; RPS6; RPL35; RPL12; RPL7A; RPLP2; RPL27A; RPS13; RPS3; RPS25; RPS24; RPL41; RPL6; RPLP0; RPL21; RPLP1; RPS17; RPS15A; RPL13; RPL26; RPL23; RPL19; RPL38; RPS21; RPS15; RPL36; RPS28; RPL18A; RPS16; RPS19; RPL18; RPL13A; RPS11; RPS9; RPL28; RPS5; RPL3
R-HSA-72706	GTP hydrolysis and joining of the 60S ribosomal subunit	31.90	0	0	66/106	RPL11; RPS8; RPL5; RPS27; RPS7; RPS27A; RPL31; RPL37A; RPL32; RPL15; RPL14; RPL29; RPL24; RPL35A; RPL9; RPL34; RPS3A; RPL37; RPS23; RPS14; RPS18; RPL10A; RPS12; RPS4X; RPL36A; RPL39; RPL10; RPS20; RPL7; RPL30; RPS6; RPL35; RPL12; RPL7A; RPLP2; RPL27A; RPS13; RPS3; RPS25; RPS24; RPL41; RPL6; RPLP0; RPL21; RPLP1; RPS17; RPS15A; RPL13; RPL26; RPL23; RPL19; RPL38; RPS21; RPS15; RPL36; RPS28; RPL18A; RPS16; RPS19; RPL18; RPL13A; RPS11; RPS9; RPL28; RPS5; RPL3
R-HSA-72613	Eukaryotic Translation Initiation	30.00	0	0	66/113	RPL11; RPS8; RPL5; RPS27; RPS7; RPS27A; RPL31; RPL37A; RPL32; RPL15; RPL14; RPL29; RPL24; RPL35A; RPL9; RPL34; RPS3A; RPL37; RPS23; RPS14; RPS18; RPL10A; RPS12; RPS4X; RPL36A; RPL39; RPL10; RPS20; RPL7; RPL30; RPS6; RPL35; RPL12; RPL7A; RPLP2; RPL27A; RPS13; RPS3; RPS25; RPS24; RPL41; RPL6; RPLP0; RPL21; RPLP1; RPS17; RPS15A; RPL13; RPL26; RPL23; RPL19; RPL38; RPS21; RPS15; RPL36; RPS28; RPL18A; RPS16; RPS19; RPL18; RPL13A; RPS11; RPS9; RPL28; RPS5; RPL3
R-HSA-72737	Cap-dependent Translation Initiation	30.00	0	0	66/113	RPL11; RPS8; RPL5; RPS27; RPS7; RPS27A; RPL31; RPL37A; RPL32; RPL15; RPL14; RPL29; RPL24; RPL35A; RPL9; RPL34; RPS3A; RPL37; RPS23; RPS14; RPS18; RPL10A; RPS12; RPS4X; RPL36A; RPL39; RPL10; RPS20; RPL7; RPL30; RPS6; RPL35; RPL12; RPL7A; RPLP2; RPL27A; RPS13; RPS3; RPS25; RPS24; RPL41; RPL6; RPLP0; RPL21; RPLP1; RPS17; RPS15A; RPL13; RPL26; RPL23; RPL19; RPL38; RPS21; RPS15; RPL36; RPS28; RPL18A; RPS16; RPS19; RPL18; RPL13A; RPS11; RPS9; RPL28; RPS5; RPL3
R-HSA-168273	Influenza Viral RNA Transcription and Replication	30.00	0	0	66/113	RPL11; RPS8; RPL5; RPS27; RPS7; RPS27A; RPL31; RPL37A; RPL32; RPL15; RPL14; RPL29; RPL24; RPL35A; RPL9; RPL34; RPS3A; RPL37; RPS23; RPS14; RPS18; RPL10A; RPS12; RPS4X; RPL36A; RPL39; RPL10; RPS20; RPL7; RPL30; RPS6; RPL35; RPL12; RPL7A; RPLP2; RPL27A; RPS13; RPS3; RPS25; RPS24; RPL41; RPL6; RPLP0; RPL21; RPLP1; RPS17; RPS15A; RPL13; RPL26; RPL23; RPL19; RPL38; RPS21; RPS15; RPL36; RPS28; RPL18A; RPS16; RPS19; RPL18; RPL13A; RPS11; RPS9; RPL28; RPS5; RPL3
R-HSA-168255	Influenza Life Cycle	28.00	0	0	66/121	RPL11; RPS8; RPL5; RPS27; RPS7; RPS27A; RPL31; RPL37A; RPL32; RPL15; RPL14; RPL29; RPL24; RPL35A; RPL9; RPL34; RPS3A; RPL37; RPS23; RPS14; RPS18; RPL10A; RPS12; RPS4X; RPL36A; RPL39; RPL10; RPS20; RPL7; RPL30; RPS6; RPL35; RPL12; RPL7A; RPLP2; RPL27A; RPS13; RPS3; RPS25; RPS24; RPL41; RPL6; RPLP0; RPL21; RPLP1; RPS17; RPS15A; RPL13; RPL26; RPL23; RPL19; RPL38; RPS21; RPS15; RPL36; RPS28; RPL18A; RPS16; RPS19; RPL18; RPL13A; RPS11; RPS9; RPL28; RPS5; RPL3
R-HSA-72695	Formation of the ternary complex, and subsequently, the 43S complex	27.80	0	0	26/48	RPS8; RPS27; RPS7; RPS27A; RPS3A; RPS23; RPS14; RPS18; RPS12; RPS4X; RPS20; RPS6; RPS13; RPS3; RPS25; RPS24; RPS17; RPS15A; RPS21; RPS15; RPS28; RPS16; RPS19; RPS11; RPS9; RPS5
R-HSA-168254	Influenza Infection	26.80	0	0	67/128	RPL11; RPS8; RPL5; RPS27; RPS7; RPS27A; RPL31; RPL37A; RPL32; RPL15; RPL14; RPL29; RPL24; RPL35A; RPL9; RPL34; RPS3A; RPL37; RPS23; RPS14; RPS18; RPL10A; RPS12; SLC25A6; RPS4X; RPL36A; RPL39; RPL10; RPS20; RPL7; RPL30; RPS6; RPL35; RPL12; RPL7A; RPLP2; RPL27A; RPS13; RPS3; RPS25; RPS24; RPL41; RPL6; RPLP0; RPL21; RPLP1; RPS17; RPS15A; RPL13; RPL26; RPL23; RPL19; RPL38; RPS21; RPS15; RPL36; RPS28; RPL18A; RPS16; RPS19; RPL18; RPL13A; RPS11; RPS9; RPL28; RPS5; RPL3
R-HSA-72649	Translation initiation complex formation	24.20	0	0	26/55	RPS8; RPS27; RPS7; RPS27A; RPS3A; RPS23; RPS14; RPS18; RPS12; RPS4X; RPS20; RPS6; RPS13; RPS3; RPS25; RPS24; RPS17; RPS15A; RPS21; RPS15; RPS28; RPS16; RPS19; RPS11; RPS9; RPS5
R-HSA-72702	Ribosomal scanning and start codon recognition	24.20	0	0	26/55	RPS8; RPS27; RPS7; RPS27A; RPS3A; RPS23; RPS14; RPS18; RPS12; RPS4X; RPS20; RPS6; RPS13; RPS3; RPS25; RPS24; RPS17; RPS15A; RPS21; RPS15; RPS28; RPS16; RPS19; RPS11; RPS9; RPS5
R-HSA-72662	Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S	23.80	0	0	26/56	RPS8; RPS27; RPS7; RPS27A; RPS3A; RPS23; RPS14; RPS18; RPS12; RPS4X; RPS20; RPS6; RPS13; RPS3; RPS25; RPS24; RPS17; RPS15A; RPS21; RPS15; RPS28; RPS16; RPS19; RPS11; RPS9; RPS5
R-HSA-9010553	Regulation of expression of SLITs and ROBOs	22.70	0	0	66/149	RPL11; RPS8; RPL5; RPS27; RPS7; RPS27A; RPL31; RPL37A; RPL32; RPL15; RPL14; RPL29; RPL24; RPL35A; RPL9; RPL34; RPS3A; RPL37; RPS23; RPS14; RPS18; RPL10A; RPS12; RPS4X; RPL36A; RPL39; RPL10; RPS20; RPL7; RPL30; RPS6; RPL35; RPL12; RPL7A; RPLP2; RPL27A; RPS13; RPS3; RPS25; RPS24; RPL41; RPL6; RPLP0; RPL21; RPLP1; RPS17; RPS15A; RPL13; RPL26; RPL23; RPL19; RPL38; RPS21; RPS15; RPL36; RPS28; RPL18A; RPS16; RPS19; RPL18; RPL13A; RPS11; RPS9; RPL28; RPS5; RPL3
R-HSA-6791226	Major pathway of rRNA processing in the nucleolus and cytosol	22.00	0	0	66/154	RPL11; RPS8; RPL5; RPS27; RPS7; RPS27A; RPL31; RPL37A; RPL32; RPL15; RPL14; RPL29; RPL24; RPL35A; RPL9; RPL34; RPS3A; RPL37; RPS23; RPS14; RPS18; RPL10A; RPS12; RPS4X; RPL36A; RPL39; RPL10; RPS20; RPL7; RPL30; RPS6; RPL35; RPL12; RPL7A; RPLP2; RPL27A; RPS13; RPS3; RPS25; RPS24; RPL41; RPL6; RPLP0; RPL21; RPLP1; RPS17; RPS15A; RPL13; RPL26; RPL23; RPL19; RPL38; RPS21; RPS15; RPL36; RPS28; RPL18A; RPS16; RPS19; RPL18; RPL13A; RPS11; RPS9; RPL28; RPS5; RPL3
R-HSA-8868773	rRNA processing in the nucleus and cytosol	21.20	0	0	66/160	RPL11; RPS8; RPL5; RPS27; RPS7; RPS27A; RPL31; RPL37A; RPL32; RPL15; RPL14; RPL29; RPL24; RPL35A; RPL9; RPL34; RPS3A; RPL37; RPS23; RPS14; RPS18; RPL10A; RPS12; RPS4X; RPL36A; RPL39; RPL10; RPS20; RPL7; RPL30; RPS6; RPL35; RPL12; RPL7A; RPLP2; RPL27A; RPS13; RPS3; RPS25; RPS24; RPL41; RPL6; RPLP0; RPL21; RPLP1; RPS17; RPS15A; RPL13; RPL26; RPL23; RPL19; RPL38; RPS21; RPS15; RPL36; RPS28; RPL18A; RPS16; RPS19; RPL18; RPL13A; RPS11; RPS9; RPL28; RPS5; RPL3
R-HSA-72312	rRNA processing	20.60	0	0	66/164	RPL11; RPS8; RPL5; RPS27; RPS7; RPS27A; RPL31; RPL37A; RPL32; RPL15; RPL14; RPL29; RPL24; RPL35A; RPL9; RPL34; RPS3A; RPL37; RPS23; RPS14; RPS18; RPL10A; RPS12; RPS4X; RPL36A; RPL39; RPL10; RPS20; RPL7; RPL30; RPS6; RPL35; RPL12; RPL7A; RPLP2; RPL27A; RPS13; RPS3; RPS25; RPS24; RPL41; RPL6; RPLP0; RPL21; RPLP1; RPS17; RPS15A; RPL13; RPL26; RPL23; RPL19; RPL38; RPS21; RPS15; RPL36; RPS28; RPL18A; RPS16; RPS19; RPL18; RPL13A; RPS11; RPS9; RPL28; RPS5; RPL3
R-HSA-376176	Signaling by ROBO receptors	19.00	0	0	66/178	RPL11; RPS8; RPL5; RPS27; RPS7; RPS27A; RPL31; RPL37A; RPL32; RPL15; RPL14; RPL29; RPL24; RPL35A; RPL9; RPL34; RPS3A; RPL37; RPS23; RPS14; RPS18; RPL10A; RPS12; RPS4X; RPL36A; RPL39; RPL10; RPS20; RPL7; RPL30; RPS6; RPL35; RPL12; RPL7A; RPLP2; RPL27A; RPS13; RPS3; RPS25; RPS24; RPL41; RPL6; RPLP0; RPL21; RPLP1; RPS17; RPS15A; RPL13; RPL26; RPL23; RPL19; RPL38; RPS21; RPS15; RPL36; RPS28; RPL18A; RPS16; RPS19; RPL18; RPL13A; RPS11; RPS9; RPL28; RPS5; RPL3
R-HSA-71291	Metabolism of amino acids and derivatives	16.20	0	0	66/209	RPL11; RPS8; RPL5; RPS27; RPS7; RPS27A; RPL31; RPL37A; RPL32; RPL15; RPL14; RPL29; RPL24; RPL35A; RPL9; RPL34; RPS3A; RPL37; RPS23; RPS14; RPS18; RPL10A; RPS12; RPS4X; RPL36A; RPL39; RPL10; RPS20; RPL7; RPL30; RPS6; RPL35; RPL12; RPL7A; RPLP2; RPL27A; RPS13; RPS3; RPS25; RPS24; RPL41; RPL6; RPLP0; RPL21; RPLP1; RPS17; RPS15A; RPL13; RPL26; RPL23; RPL19; RPL38; RPS21; RPS15; RPL36; RPS28; RPL18A; RPS16; RPS19; RPL18; RPL13A; RPS11; RPS9; RPL28; RPS5; RPL3
R-HSA-72766	Translation	13.20	0	0	66/257	RPL11; RPS8; RPL5; RPS27; RPS7; RPS27A; RPL31; RPL37A; RPL32; RPL15; RPL14; RPL29; RPL24; RPL35A; RPL9; RPL34; RPS3A; RPL37; RPS23; RPS14; RPS18; RPL10A; RPS12; RPS4X; RPL36A; RPL39; RPL10; RPS20; RPL7; RPL30; RPS6; RPL35; RPL12; RPL7A; RPLP2; RPL27A; RPS13; RPS3; RPS25; RPS24; RPL41; RPL6; RPLP0; RPL21; RPLP1; RPS17; RPS15A; RPL13; RPL26; RPL23; RPL19; RPL38; RPS21; RPS15; RPL36; RPS28; RPL18A; RPS16; RPS19; RPL18; RPL13A; RPS11; RPS9; RPL28; RPS5; RPL3
R-HSA-5663205	Infectious disease	12.50	0	0	67/275	RPL11; RPS8; RPL5; RPS27; RPS7; RPS27A; RPL31; RPL37A; RPL32; RPL15; RPL14; RPL29; RPL24; RPL35A; RPL9; RPL34; RPS3A; RPL37; RPS23; RPS14; RPS18; RPL10A; RPS12; SLC25A6; RPS4X; RPL36A; RPL39; RPL10; RPS20; RPL7; RPL30; RPS6; RPL35; RPL12; RPL7A; RPLP2; RPL27A; RPS13; RPS3; RPS25; RPS24; RPL41; RPL6; RPLP0; RPL21; RPLP1; RPS17; RPS15A; RPL13; RPL26; RPL23; RPL19; RPL38; RPS21; RPS15; RPL36; RPS28; RPL18A; RPS16; RPS19; RPL18; RPL13A; RPS11; RPS9; RPL28; RPS5; RPL3
R-HSA-422475	Axon guidance	10.30	0	0	66/328	RPL11; RPS8; RPL5; RPS27; RPS7; RPS27A; RPL31; RPL37A; RPL32; RPL15; RPL14; RPL29; RPL24; RPL35A; RPL9; RPL34; RPS3A; RPL37; RPS23; RPS14; RPS18; RPL10A; RPS12; RPS4X; RPL36A; RPL39; RPL10; RPS20; RPL7; RPL30; RPS6; RPL35; RPL12; RPL7A; RPLP2; RPL27A; RPS13; RPS3; RPS25; RPS24; RPL41; RPL6; RPLP0; RPL21; RPLP1; RPS17; RPS15A; RPL13; RPL26; RPL23; RPL19; RPL38; RPS21; RPS15; RPL36; RPS28; RPL18A; RPS16; RPS19; RPL18; RPL13A; RPS11; RPS9; RPL28; RPS5; RPL3
R-HSA-1266738	Developmental Biology	7.61	0	0	66/445	RPL11; RPS8; RPL5; RPS27; RPS7; RPS27A; RPL31; RPL37A; RPL32; RPL15; RPL14; RPL29; RPL24; RPL35A; RPL9; RPL34; RPS3A; RPL37; RPS23; RPS14; RPS18; RPL10A; RPS12; RPS4X; RPL36A; RPL39; RPL10; RPS20; RPL7; RPL30; RPS6; RPL35; RPL12; RPL7A; RPLP2; RPL27A; RPS13; RPS3; RPS25; RPS24; RPL41; RPL6; RPLP0; RPL21; RPLP1; RPS17; RPS15A; RPL13; RPL26; RPL23; RPL19; RPL38; RPS21; RPS15; RPL36; RPS28; RPL18A; RPS16; RPS19; RPL18; RPL13A; RPS11; RPS9; RPL28; RPS5; RPL3
R-HSA-1643685	Disease	7.41	0	0	67/464	RPL11; RPS8; RPL5; RPS27; RPS7; RPS27A; RPL31; RPL37A; RPL32; RPL15; RPL14; RPL29; RPL24; RPL35A; RPL9; RPL34; RPS3A; RPL37; RPS23; RPS14; RPS18; RPL10A; RPS12; SLC25A6; RPS4X; RPL36A; RPL39; RPL10; RPS20; RPL7; RPL30; RPS6; RPL35; RPL12; RPL7A; RPLP2; RPL27A; RPS13; RPS3; RPS25; RPS24; RPL41; RPL6; RPLP0; RPL21; RPLP1; RPS17; RPS15A; RPL13; RPL26; RPL23; RPL19; RPL38; RPS21; RPS15; RPL36; RPS28; RPL18A; RPS16; RPS19; RPL18; RPL13A; RPS11; RPS9; RPL28; RPS5; RPL3

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Factor 4 : 48 significant Reactome pathways

GeneSet	description	enrichRatio	pValue	FDR	GeneRatio	geneSymbols
R-HSA-5576892	Phase 0 - rapid depolarisation	7.97	2.17e-04	9.34e-03	5/12	SCN3A; SCN9A; CAMK2B; CALM1
R-HSA-373080	Class B/2 (Secretin family receptors)	7.36	3.38e-04	1.12e-02	5/13	GNG5; GNG4; FZD1; GNG8; PTH2
R-HSA-442729	CREB phosphorylation through the activation of CaMKII	6.96	1.79e-03	3.63e-02	4/11	CAMK2B; NEFL; CALM1
R-HSA-442982	Ras activation upon Ca2+ influx through NMDA receptor	6.96	1.79e-03	3.63e-02	4/11	CAMK2B; NEFL; CALM1
R-HSA-500792	GPCR ligand binding	6.38	4.97e-06	1.03e-03	9/27	GNG5; AGT; GNG4; GRM4; FZD1; GAL; SSTR2; GNG8; PTH2
R-HSA-5626467	RHO GTPases activate IQGAPs	6.38	2.06e-04	9.34e-03	6/18	TUBB2B; ACTB; CALM1; ACTG1; TUBB4A
R-HSA-445095	Interaction between L1 and Ankyrins	6.38	7.23e-04	2.07e-02	5/15	SCN3A; SCN9A; ACTB; ANK3; ACTG1
R-HSA-392170	ADP signalling through P2Y purinoceptor 12	6.38	2.57e-03	4.51e-02	4/12	GNG5; GNG4; GNAI2; GNG8
R-HSA-400042	Adrenaline,noradrenaline inhibits insulin secretion	6.38	2.57e-03	4.51e-02	4/12	GNG5; GNG4; GNAI2; GNG8
R-HSA-451326	Activation of kainate receptors upon glutamate binding	5.98	1.01e-03	2.63e-02	5/16	GNG5; GNG4; CALM1; GNG8
R-HSA-5578775	Ion homeostasis	5.82	1.14e-04	6.56e-03	7/23	ATP1B1; RYR2; CAMK2B; SRI; CALM1; FXYD7
R-HSA-445355	Smooth Muscle Contraction	5.63	1.37e-03	3.10e-02	5/17	CALD1; MYL6; CALM1; MYL12A
R-HSA-5576891	Cardiac conduction	5.47	7.00e-06	1.03e-03	10/35	ATP1B1; RYR2; SCN3A; SCN9A; CAMK2B; SRI; AKAP9; CALM1; FXYD7
R-HSA-190828	Gap junction trafficking	5.31	1.81e-03	3.63e-02	5/18	AP2M1; TUBB2B; ACTB; ACTG1; TUBB4A
R-HSA-397014	Muscle contraction	5.22	6.38e-08	5.49e-05	15/55	ATP1B1; RYR2; SCN3A; SCN9A; MYL1; CAMK2B; SRI; AKAP9; CALD1; MYL6; CALM1; ACTC1; MYL12A; FXYD7
R-HSA-157858	Gap junction trafficking and regulation	5.03	2.36e-03	4.32e-02	5/19	AP2M1; TUBB2B; ACTB; ACTG1; TUBB4A
R-HSA-2672351	Stimuli-sensing channels	4.78	1.15e-03	2.67e-02	6/24	RYR2; RPS27A; SRI; CALM1; TTYH2
R-HSA-936837	Ion transport by P-type ATPases	4.78	1.15e-03	2.67e-02	6/24	ATP1B1; CAMK2B; SRI; CALM1; FXYD7
R-HSA-418555	G alpha (s) signalling events	4.78	1.15e-03	2.67e-02	6/24	GNG5; GNG4; REEP1; GNAI2; GNG8; PTH2
R-HSA-437239	Recycling pathway of L1	4.62	5.57e-04	1.71e-02	7/29	AP2M1; TUBB2B; EZR; ACTB; DPYSL2; ACTG1; TUBB4A
R-HSA-418346	Platelet homeostasis	4.46	6.95e-04	2.06e-02	7/30	GNG5; GNG4; SRI; CALM1; GNG8; PDE9A
R-HSA-112314	Neurotransmitter receptors and postsynaptic signal transmission	4.29	3.01e-05	3.24e-03	11/49	GNG5; GNG4; CHRNA1; GNAI2; AP2M1; GRIA2; CAMK2B; NEFL; CALM1; GNG8
R-HSA-373755	Semaphorin interactions	3.94	1.54e-03	3.39e-02	7/34	RHOC; DPYSL3; HSP90AB1; DPYSL2; CFL1; MYL6; MYL12A
R-HSA-418594	G alpha (i) signalling events	3.53	1.02e-04	6.56e-03	12/65	GNG5; RGS16; AGT; GNG4; GNAI2; GRM4; GAL; RGS10; CALM1; SSTR2; GNG8
R-HSA-373760	L1CAM interactions	3.38	1.61e-04	7.70e-03	12/68	SCN3A; SCN9A; NRP2; ALCAM; AP2M1; TUBB2B; EZR; ACTB; DPYSL2; ANK3; ACTG1; TUBB4A
R-HSA-156842	Eukaryotic Translation Elongation	3.34	2.77e-05	3.24e-03	15/86	RPS27A; EEF1B2; RPL29; RPS3A; RPL37; RPS4X; RPL39; RPL7; RPL12; RPL27A; RPS3; RPLP0; RPLP1; RPS11; RPL28
R-HSA-112315	Transmission across Chemical Synapses	3.23	7.61e-05	6.55e-03	14/83	GNG5; GNG4; CHRNA1; GNAI2; AP2M1; GRIA2; CAMK2B; STX1A; NEFL; CALM1; CACNA1A; RAB3A; GNG8
R-HSA-192823	Viral mRNA Translation	3.23	7.61e-05	6.55e-03	14/83	RPS27A; RPL29; RPS3A; RPL37; RPS4X; RPL39; RPL7; RPL12; RPL27A; RPS3; RPLP0; RPLP1; RPS11; RPL28
R-HSA-112316	Neuronal System	3.22	7.17e-06	1.03e-03	18/107	PTPRF; GNG5; GNG4; NRXN1; CHRNA1; GNAI2; AP2M1; GRIA2; CAMK2B; STX1A; NEFL; SYT7; CALM1; CACNA1A; RAB3A; HOMER3; GNG8
R-HSA-156902	Peptide chain elongation	3.19	8.71e-05	6.56e-03	14/84	RPS27A; RPL29; RPS3A; RPL37; RPS4X; RPL39; RPL7; RPL12; RPL27A; RPS3; RPLP0; RPLP1; RPS11; RPL28
R-HSA-2408557	Selenocysteine synthesis	3.15	9.96e-05	6.56e-03	14/85	RPS27A; RPL29; RPS3A; RPL37; RPS4X; RPL39; RPL7; RPL12; RPL27A; RPS3; RPLP0; RPLP1; RPS11; RPL28
R-HSA-72764	Eukaryotic Translation Termination	3.11	1.14e-04	6.56e-03	14/86	RPS27A; RPL29; RPS3A; RPL37; RPS4X; RPL39; RPL7; RPL12; RPL27A; RPS3; RPLP0; RPLP1; RPS11; RPL28
R-HSA-975956	Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)	3.04	1.47e-04	7.43e-03	14/88	RPS27A; RPL29; RPS3A; RPL37; RPS4X; RPL39; RPL7; RPL12; RPL27A; RPS3; RPLP0; RPLP1; RPS11; RPL28
R-HSA-72689	Formation of a pool of free 40S subunits	2.82	3.37e-04	1.12e-02	14/95	RPS27A; RPL29; RPS3A; RPL37; RPS4X; RPL39; RPL7; RPL12; RPL27A; RPS3; RPLP0; RPLP1; RPS11; RPL28
R-HSA-927802	Nonsense-Mediated Decay (NMD)	2.73	2.93e-04	1.07e-02	15/105	RPS27A; RPL29; RPS3A; RPL37; RPS4X; RPL39; RPL7; RPL12; RPL27A; RPS3; RPLP0; RPLP1; EIF4A3; RPS11; RPL28
R-HSA-975957	Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)	2.73	2.93e-04	1.07e-02	15/105	RPS27A; RPL29; RPS3A; RPL37; RPS4X; RPL39; RPL7; RPL12; RPL27A; RPS3; RPLP0; RPLP1; EIF4A3; RPS11; RPL28
R-HSA-372790	Signaling by GPCR	2.71	1.27e-04	6.86e-03	17/120	GNG5; RHOC; RGS16; AGT; GNG4; REEP1; GNAI2; GRM4; FZD1; GAL; RGS10; CALM1; SSTR2; PREX1; GNG8; PTH2
R-HSA-2408522	Selenoamino acid metabolism	2.71	5.21e-04	1.66e-02	14/99	RPS27A; RPL29; RPS3A; RPL37; RPS4X; RPL39; RPL7; RPL12; RPL27A; RPS3; RPLP0; RPLP1; RPS11; RPL28
R-HSA-388396	GPCR downstream signalling	2.64	2.78e-04	1.07e-02	16/116	GNG5; RHOC; RGS16; AGT; GNG4; REEP1; GNAI2; GRM4; GAL; RGS10; CALM1; SSTR2; PREX1; GNG8; PTH2
R-HSA-1799339	SRP-dependent cotranslational protein targeting to membrane	2.58	8.65e-04	2.40e-02	14/104	RPS27A; RPL29; RPS3A; RPL37; RPS4X; RPL39; RPL7; RPL12; RPL27A; RPS3; RPLP0; RPLP1; RPS11; RPL28
R-HSA-156827	L13a-mediated translational silencing of Ceruloplasmin expression	2.55	9.53e-04	2.56e-02	14/105	RPS27A; RPL29; RPS3A; RPL37; RPS4X; RPL39; RPL7; RPL12; RPL27A; RPS3; RPLP0; RPLP1; RPS11; RPL28
R-HSA-72706	GTP hydrolysis and joining of the 60S ribosomal subunit	2.53	1.05e-03	2.65e-02	14/106	RPS27A; RPL29; RPS3A; RPL37; RPS4X; RPL39; RPL7; RPL12; RPL27A; RPS3; RPLP0; RPLP1; RPS11; RPL28
R-HSA-72613	Eukaryotic Translation Initiation	2.37	1.97e-03	3.68e-02	14/113	RPS27A; RPL29; RPS3A; RPL37; RPS4X; RPL39; RPL7; RPL12; RPL27A; RPS3; RPLP0; RPLP1; RPS11; RPL28
R-HSA-72737	Cap-dependent Translation Initiation	2.37	1.97e-03	3.68e-02	14/113	RPS27A; RPL29; RPS3A; RPL37; RPS4X; RPL39; RPL7; RPL12; RPL27A; RPS3; RPLP0; RPLP1; RPS11; RPL28
R-HSA-168273	Influenza Viral RNA Transcription and Replication	2.37	1.97e-03	3.68e-02	14/113	RPS27A; RPL29; RPS3A; RPL37; RPS4X; RPL39; RPL7; RPL12; RPL27A; RPS3; RPLP0; RPLP1; RPS11; RPL28
R-HSA-109582	Hemostasis	2.26	2.98e-04	1.07e-02	21/178	PRKCZ; GNG5; TAGLN2; ATP1B1; GNG4; GYPC; GNAI2; TUBB2B; HDAC2; ACTB; SRI; TMSB4X; CFL1; CD63; CALM1; KIF19; BSG; TUBB4A; GNG8; PDE9A
R-HSA-422475	Axon guidance	2.22	1.17e-06	5.02e-04	38/328	RHOC; LHX9; RPS27A; SCN3A; SCN9A; NRP2; RPL29; ALCAM; AP2M1; RPS3A; RPL37; RGMB; DPYSL3; PDLIM7; TUBB2B; HSP90AB1; EZR; ACTB; RPS4X; RPL39; DPYSL2; RPL7; RPL12; RPL27A; CFL1; RPS3; ANK3; MYL6; RPLP0; RPLP1; EFNB3; EIF4A3; ACTG1; MYL12A; PSMA7; TUBB4A; RPS11; RPL28
R-HSA-9010553	Regulation of expression of SLITs and ROBOs	2.18	1.67e-03	3.60e-02	17/149	LHX9; RPS27A; RPL29; RPS3A; RPL37; RPS4X; RPL39; RPL7; RPL12; RPL27A; RPS3; RPLP0; RPLP1; EIF4A3; PSMA7; RPS11; RPL28

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Factor 5 : 152 significant Reactome pathways

GeneSet	description	enrichRatio	pValue	FDR	GeneRatio	geneSymbols
R-HSA-8978934	Metabolism of cofactors	6.14	7.34e-04	4.45e-03	5/12	COQ5; CALM1; HSP90AA1; COQ9
R-HSA-3371568	Attenuation phase	5.90	3.13e-03	1.76e-02	4/10	HSP90AB1; HSF1; HSPA8; HSP90AA1
R-HSA-450408	AUF1 (hnRNP D0) binds and destabilizes mRNA	5.33	3.40e-09	1.48e-06	17/47	PSMD6; PSMD2; PSMB1; HSPB1; PSMC2; PSMB7; PSMD13; HSPA8; UBC; PSMC6; PSMC1; PSMB6; PSMD11; PSMB3; PSMD3; PSMA7; PSMD8
R-HSA-1236978	Cross-presentation of soluble exogenous antigens (endosomes)	5.29	9.79e-08	3.24e-06	14/39	PSMD6; PSMD2; PSMB1; PSMC2; PSMB7; PSMD13; PSMC6; PSMC1; PSMB6; PSMD11; PSMB3; PSMD3; PSMA7; PSMD8
R-HSA-180534	Vpu mediated degradation of CD4	5.14	5.23e-08	2.82e-06	15/43	PSMD6; PSMD2; PSMB1; PSMC2; PSMB7; PSMD13; UBC; PSMC6; PSMC1; PSMB6; PSMD11; PSMB3; PSMD3; PSMA7; PSMD8
R-HSA-211733	Regulation of activated PAK-2p34 by proteasome mediated degradation	5.14	5.23e-08	2.82e-06	15/43	PSMD6; PSMD2; PSMB1; PSMC2; PSMB7; PSMD13; UBC; PSMC6; PSMC1; PSMB6; PSMD11; PSMB3; PSMD3; PSMA7; PSMD8
R-HSA-69601	Ubiquitin Mediated Degradation of Phosphorylated Cdc25A	5.14	5.23e-08	2.82e-06	15/43	PSMD6; PSMD2; PSMB1; PSMC2; PSMB7; PSMD13; UBC; PSMC6; PSMC1; PSMB6; PSMD11; PSMB3; PSMD3; PSMA7; PSMD8
R-HSA-69610	p53-Independent DNA Damage Response	5.14	5.23e-08	2.82e-06	15/43	PSMD6; PSMD2; PSMB1; PSMC2; PSMB7; PSMD13; UBC; PSMC6; PSMC1; PSMB6; PSMD11; PSMB3; PSMD3; PSMA7; PSMD8
R-HSA-69613	p53-Independent G1/S DNA damage checkpoint	5.14	5.23e-08	2.82e-06	15/43	PSMD6; PSMD2; PSMB1; PSMC2; PSMB7; PSMD13; UBC; PSMC6; PSMC1; PSMB6; PSMD11; PSMB3; PSMD3; PSMA7; PSMD8
R-HSA-69229	Ubiquitin-dependent degradation of Cyclin D1	5.03	7.47e-08	3.21e-06	15/44	PSMD6; PSMD2; PSMB1; PSMC2; PSMB7; PSMD13; UBC; PSMC6; PSMC1; PSMB6; PSMD11; PSMB3; PSMD3; PSMA7; PSMD8
R-HSA-75815	Ubiquitin-dependent degradation of Cyclin D	5.03	7.47e-08	3.21e-06	15/44	PSMD6; PSMD2; PSMB1; PSMC2; PSMB7; PSMD13; UBC; PSMC6; PSMC1; PSMB6; PSMD11; PSMB3; PSMD3; PSMA7; PSMD8
R-HSA-169911	Regulation of Apoptosis	5.03	7.47e-08	3.21e-06	15/44	PSMD6; PSMD2; PSMB1; PSMC2; PSMB7; PSMD13; UBC; PSMC6; PSMC1; PSMB6; PSMD11; PSMB3; PSMD3; PSMA7; PSMD8
R-HSA-174113	SCF-beta-TrCP mediated degradation of Emi1	5.03	7.47e-08	3.21e-06	15/44	PSMD6; PSMD2; PSMB1; PSMC2; PSMB7; PSMD13; UBC; PSMC6; PSMC1; PSMB6; PSMD11; PSMB3; PSMD3; PSMA7; PSMD8
R-HSA-187577	SCF(Skp2)-mediated degradation of p27/p21	5.02	2.75e-08	2.49e-06	16/47	CKS1B; PSMD6; PSMD2; PSMB1; PSMC2; PSMB7; PSMD13; UBC; PSMC6; PSMC1; PSMB6; PSMD11; PSMB3; PSMD3; PSMA7; PSMD8
R-HSA-5607761	Dectin-1 mediated noncanonical NF-kB signaling	5.02	2.75e-08	2.49e-06	16/47	PSMD6; UBA3; PSMD2; PSMB1; PSMC2; PSMB7; PSMD13; UBC; PSMC6; PSMC1; PSMB6; PSMD11; PSMB3; PSMD3; PSMA7; PSMD8
R-HSA-5676590	NIK-->noncanonical NF-kB signaling	5.02	2.75e-08	2.49e-06	16/47	PSMD6; UBA3; PSMD2; PSMB1; PSMC2; PSMB7; PSMD13; UBC; PSMC6; PSMC1; PSMB6; PSMD11; PSMB3; PSMD3; PSMA7; PSMD8
R-HSA-5668541	TNFR2 non-canonical NF-kB pathway	4.92	3.88e-08	2.82e-06	16/48	PSMD6; UBA3; PSMD2; PSMB1; PSMC2; PSMB7; PSMD13; UBC; PSMC6; PSMC1; PSMB6; PSMD11; PSMB3; PSMD3; PSMA7; PSMD8
R-HSA-349425	Autodegradation of the E3 ubiquitin ligase COP1	4.92	1.05e-07	3.24e-06	15/45	PSMD6; PSMD2; PSMB1; PSMC2; PSMB7; PSMD13; UBC; PSMC6; PSMC1; PSMB6; PSMD11; PSMB3; PSMD3; PSMA7; PSMD8
R-HSA-4641258	Degradation of DVL	4.92	1.05e-07	3.24e-06	15/45	PSMD6; PSMD2; PSMB1; PSMC2; PSMB7; PSMD13; UBC; PSMC6; PSMC1; PSMB6; PSMD11; PSMB3; PSMD3; PSMA7; PSMD8
R-HSA-68827	CDT1 association with the CDC6:ORC:origin complex	4.92	1.05e-07	3.24e-06	15/45	PSMD6; PSMD2; PSMB1; PSMC2; PSMB7; PSMD13; UBC; PSMC6; PSMC1; PSMB6; PSMD11; PSMB3; PSMD3; PSMA7; PSMD8
R-HSA-8854050	FBXL7 down-regulates AURKA during mitotic entry and in early mitosis	4.92	1.05e-07	3.24e-06	15/45	PSMD6; PSMD2; PSMB1; PSMC2; PSMB7; PSMD13; UBC; PSMC6; PSMC1; PSMB6; PSMD11; PSMB3; PSMD3; PSMA7; PSMD8
R-HSA-8941858	Regulation of RUNX3 expression and activity	4.92	1.05e-07	3.24e-06	15/45	PSMD6; PSMD2; PSMB1; PSMC2; PSMB7; PSMD13; UBC; PSMC6; PSMC1; PSMB6; PSMD11; PSMB3; PSMD3; PSMA7; PSMD8
R-HSA-8852276	The role of GTSE1 in G2/M progression after G2 checkpoint	4.83	7.35e-09	1.58e-06	18/55	PSMD6; PSMD2; HSP90AB1; PSMB1; PSMC2; PSMB7; PSMD13; TUBA1A; UBC; PSMC6; PSMC1; HSP90AA1; PSMB6; PSMD11; PSMB3; PSMD3; PSMA7; PSMD8
R-HSA-180585	Vif-mediated degradation of APOBEC3G	4.81	1.47e-07	3.51e-06	15/46	PSMD6; PSMD2; PSMB1; PSMC2; PSMB7; PSMD13; UBC; PSMC6; PSMC1; PSMB6; PSMD11; PSMB3; PSMD3; PSMA7; PSMD8
R-HSA-4641257	Degradation of AXIN	4.81	1.47e-07	3.51e-06	15/46	PSMD6; PSMD2; PSMB1; PSMC2; PSMB7; PSMD13; UBC; PSMC6; PSMC1; PSMB6; PSMD11; PSMB3; PSMD3; PSMA7; PSMD8
R-HSA-350562	Regulation of ornithine decarboxylase (ODC)	4.80	3.98e-07	5.80e-06	14/43	PSMD6; PSMD2; PSMB1; PSMC2; PSMB7; PSMD13; PSMC6; PSMC1; PSMB6; PSMD11; PSMB3; PSMD3; PSMA7; PSMD8
R-HSA-5362768	Hh mutants that don't undergo autocatalytic processing are degraded by ERAD	4.71	2.03e-07	4.06e-06	15/47	PSMD6; PSMD2; PSMB1; PSMC2; PSMB7; PSMD13; UBC; PSMC6; PSMC1; PSMB6; PSMD11; PSMB3; PSMD3; PSMA7; PSMD8
R-HSA-5387390	Hh mutants abrogate ligand secretion	4.71	2.03e-07	4.06e-06	15/47	PSMD6; PSMD2; PSMB1; PSMC2; PSMB7; PSMD13; UBC; PSMC6; PSMC1; PSMB6; PSMD11; PSMB3; PSMD3; PSMA7; PSMD8
R-HSA-68867	Assembly of the pre-replicative complex	4.71	2.03e-07	4.06e-06	15/47	PSMD6; PSMD2; PSMB1; PSMC2; PSMB7; PSMD13; UBC; PSMC6; PSMC1; PSMB6; PSMD11; PSMB3; PSMD3; PSMA7; PSMD8
R-HSA-9604323	Negative regulation of NOTCH4 signaling	4.71	2.03e-07	4.06e-06	15/47	PSMD6; PSMD2; PSMB1; PSMC2; PSMB7; PSMD13; UBC; PSMC6; PSMC1; PSMB6; PSMD11; PSMB3; PSMD3; PSMA7; PSMD8
R-HSA-389957	Prefoldin mediated transfer of substrate to CCT/TriC	4.69	4.27e-04	2.72e-03	7/22	PFDN2; CCT7; CCT5; TCP1; ACTB; VBP1; TUBA1A
R-HSA-5607764	CLEC7A (Dectin-1) signaling	4.67	5.15e-09	1.48e-06	19/60	PSMD6; UBA3; PSMD2; PSMB1; PSMC2; PSMB7; PSMD13; UBC; PSMC6; PSMC1; CALM1; PDPK1; PSMB6; PSMD11; PSMB3; PSMD3; PSMA7; PSMD8
R-HSA-68949	Orc1 removal from chromatin	4.61	2.77e-07	4.68e-06	15/48	PSMD6; PSMD2; PSMB1; PSMC2; PSMB7; PSMD13; UBC; PSMC6; PSMC1; PSMB6; PSMD11; PSMB3; PSMD3; PSMA7; PSMD8
R-HSA-1169091	Activation of NF-kappaB in B cells	4.61	2.77e-07	4.68e-06	15/48	PSMD6; PSMD2; PSMB1; PSMC2; PSMB7; PSMD13; UBC; PSMC6; PSMC1; PSMB6; PSMD11; PSMB3; PSMD3; PSMA7; PSMD8
R-HSA-4608870	Asymmetric localization of PCP proteins	4.61	2.77e-07	4.68e-06	15/48	PSMD6; PSMD2; PSMB1; PSMC2; PSMB7; PSMD13; UBC; PSMC6; PSMC1; PSMB6; PSMD11; PSMB3; PSMD3; PSMA7; PSMD8
R-HSA-5610780	Degradation of GLI1 by the proteasome	4.61	2.77e-07	4.68e-06	15/48	PSMD6; PSMD2; PSMB1; PSMC2; PSMB7; PSMD13; UBC; PSMC6; PSMC1; PSMB6; PSMD11; PSMB3; PSMD3; PSMA7; PSMD8
R-HSA-69541	Stabilization of p53	4.61	2.77e-07	4.68e-06	15/48	PSMD6; PSMD2; PSMB1; PSMC2; PSMB7; PSMD13; UBC; PSMC6; PSMC1; PSMB6; PSMD11; PSMB3; PSMD3; PSMA7; PSMD8
R-HSA-1168372	Downstream signaling events of B Cell Receptor (BCR)	4.58	1.91e-08	2.49e-06	18/58	PSMD6; PSMD2; PSMB1; PSMC2; PSMB7; PSMD13; UBC; PSMC6; PSMC1; CALM1; PSMB6; PSMD11; PSMB3; PSMD3; FKBP1A; PSMA7; PSMD8
R-HSA-69563	p53-Dependent G1 DNA Damage Response	4.54	1.39e-07	3.51e-06	16/52	PCBP4; PSMD6; PSMD2; PSMB1; PSMC2; PSMB7; PSMD13; UBC; PSMC6; PSMC1; PSMB6; PSMD11; PSMB3; PSMD3; PSMA7; PSMD8
R-HSA-69580	p53-Dependent G1/S DNA damage checkpoint	4.54	1.39e-07	3.51e-06	16/52	PCBP4; PSMD6; PSMD2; PSMB1; PSMC2; PSMB7; PSMD13; UBC; PSMC6; PSMC1; PSMB6; PSMD11; PSMB3; PSMD3; PSMA7; PSMD8
R-HSA-69615	G1/S DNA Damage Checkpoints	4.54	1.39e-07	3.51e-06	16/52	PCBP4; PSMD6; PSMD2; PSMB1; PSMC2; PSMB7; PSMD13; UBC; PSMC6; PSMC1; PSMB6; PSMD11; PSMB3; PSMD3; PSMA7; PSMD8
R-HSA-1234176	Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha	4.54	1.39e-07	3.51e-06	16/52	PSMD6; PSMD2; PSMB1; PSMC2; PSMB7; PSMD13; UBC; PSMC6; PSMC1; PSMB6; PSMD11; PSMB3; PSMD3; PSMA7; PSMD8; EGLN2
R-HSA-5610783	Degradation of GLI2 by the proteasome	4.51	3.76e-07	5.58e-06	15/49	PSMD6; PSMD2; PSMB1; PSMC2; PSMB7; PSMD13; UBC; PSMC6; PSMC1; PSMB6; PSMD11; PSMB3; PSMD3; PSMA7; PSMD8
R-HSA-5610785	GLI3 is processed to GLI3R by the proteasome	4.51	3.76e-07	5.58e-06	15/49	PSMD6; PSMD2; PSMB1; PSMC2; PSMB7; PSMD13; UBC; PSMC6; PSMC1; PSMB6; PSMD11; PSMB3; PSMD3; PSMA7; PSMD8
R-HSA-5678895	Defective CFTR causes cystic fibrosis	4.51	3.76e-07	5.58e-06	15/49	PSMD6; PSMD2; PSMB1; PSMC2; PSMB7; PSMD13; UBC; PSMC6; PSMC1; PSMB6; PSMD11; PSMB3; PSMD3; PSMA7; PSMD8
R-HSA-389958	Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding	4.49	5.79e-04	3.53e-03	7/23	PFDN2; CCT7; CCT5; TCP1; ACTB; VBP1; TUBA1A
R-HSA-2871837	FCERI mediated NF-kB activation	4.45	1.88e-07	4.06e-06	16/53	PSMD6; PSMD2; PSMB1; PSMC2; PSMB7; PSMD13; UBC; PSMC6; PSMC1; PDPK1; PSMB6; PSMD11; PSMB3; PSMD3; PSMA7; PSMD8
R-HSA-202424	Downstream TCR signaling	4.45	1.88e-07	4.06e-06	16/53	PSMD6; PSMD2; PSMB1; PSMC2; PSMB7; PSMD13; UBC; PSMC6; PSMC1; PDPK1; PSMB6; PSMD11; PSMB3; PSMD3; PSMA7; PSMD8
R-HSA-1236974	ER-Phagosome pathway	4.42	5.05e-07	7.13e-06	15/50	PSMD6; PSMD2; PSMB1; PSMC2; PSMB7; PSMD13; UBC; PSMC6; PSMC1; PSMB6; PSMD11; PSMB3; PSMD3; PSMA7; PSMD8
R-HSA-5358346	Hedgehog ligand biogenesis	4.42	5.05e-07	7.13e-06	15/50	PSMD6; PSMD2; PSMB1; PSMC2; PSMB7; PSMD13; UBC; PSMC6; PSMC1; PSMB6; PSMD11; PSMB3; PSMD3; PSMA7; PSMD8
R-HSA-174154	APC/C:Cdc20 mediated degradation of Securin	4.37	2.51e-07	4.68e-06	16/54	PSMD6; PSMD2; PTTG1; PSMB1; PSMC2; PSMB7; PSMD13; UBC; PSMC6; PSMC1; PSMB6; PSMD11; PSMB3; PSMD3; PSMA7; PSMD8
R-HSA-174178	APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1	4.37	2.51e-07	4.68e-06	16/54	PSMD6; PSMD2; PTTG1; PSMB1; PSMC2; PSMB7; PSMD13; UBC; PSMC6; PSMC1; PSMB6; PSMD11; PSMB3; PSMD3; PSMA7; PSMD8
R-HSA-5619084	ABC transporter disorders	4.34	6.72e-07	8.15e-06	15/51	PSMD6; PSMD2; PSMB1; PSMC2; PSMB7; PSMD13; UBC; PSMC6; PSMC1; PSMB6; PSMD11; PSMB3; PSMD3; PSMA7; PSMD8
R-HSA-1236975	Antigen processing-Cross presentation	4.34	6.72e-07	8.15e-06	15/51	PSMD6; PSMD2; PSMB1; PSMC2; PSMB7; PSMD13; UBC; PSMC6; PSMC1; PSMB6; PSMD11; PSMB3; PSMD3; PSMA7; PSMD8
R-HSA-8939902	Regulation of RUNX2 expression and activity	4.34	6.72e-07	8.15e-06	15/51	PSMD6; PSMD2; PSMB1; PSMC2; PSMB7; PSMD13; UBC; PSMC6; PSMC1; PSMB6; PSMD11; PSMB3; PSMD3; PSMA7; PSMD8
R-HSA-5339562	Uptake and actions of bacterial toxins	4.34	4.33e-03	2.32e-02	5/17	HSP90AB1; STX1A; CALM1; HSP90AA1
R-HSA-5619115	Disorders of transmembrane transporters	4.29	3.33e-07	5.30e-06	16/55	TPR; PSMD6; PSMD2; PSMB1; PSMC2; PSMB7; PSMD13; UBC; PSMC6; PSMC1; PSMB6; PSMD11; PSMB3; PSMD3; PSMA7; PSMD8
R-HSA-176409	APC/C:Cdc20 mediated degradation of mitotic proteins	4.29	3.33e-07	5.30e-06	16/55	PSMD6; PSMD2; PTTG1; PSMB1; PSMC2; PSMB7; PSMD13; UBC; PSMC6; PSMC1; PSMB6; PSMD11; PSMB3; PSMD3; PSMA7; PSMD8
R-HSA-176814	Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins	4.29	3.33e-07	5.30e-06	16/55	PSMD6; PSMD2; PTTG1; PSMB1; PSMC2; PSMB7; PSMD13; UBC; PSMC6; PSMC1; PSMB6; PSMD11; PSMB3; PSMD3; PSMA7; PSMD8
R-HSA-5658442	Regulation of RAS by GAPs	4.25	8.88e-07	1.02e-05	15/52	PSMD6; PSMD2; PSMB1; PSMC2; PSMB7; PSMD13; UBC; PSMC6; PSMC1; PSMB6; PSMD11; PSMB3; PSMD3; PSMA7; PSMD8
R-HSA-69002	DNA Replication Pre-Initiation	4.25	8.88e-07	1.02e-05	15/52	PSMD6; PSMD2; PSMB1; PSMC2; PSMB7; PSMD13; UBC; PSMC6; PSMC1; PSMB6; PSMD11; PSMB3; PSMD3; PSMA7; PSMD8
R-HSA-174084	Autodegradation of Cdh1 by Cdh1:APC/C	4.25	8.88e-07	1.02e-05	15/52	PSMD6; PSMD2; PSMB1; PSMC2; PSMB7; PSMD13; UBC; PSMC6; PSMC1; PSMB6; PSMD11; PSMB3; PSMD3; PSMA7; PSMD8
R-HSA-5632684	Hedgehog 'on' state	4.25	8.88e-07	1.02e-05	15/52	PSMD6; PSMD2; PSMB1; PSMC2; PSMB7; PSMD13; UBC; PSMC6; PSMC1; PSMB6; PSMD11; PSMB3; PSMD3; PSMA7; PSMD8
R-HSA-8939236	RUNX1 regulates transcription of genes involved in differentiation of HSCs	4.18	2.15e-07	4.21e-06	17/60	PSMD6; PSMD2; H2AFZ; HIST1H4C; PSMB1; PSMC2; PSMB7; PSMD13; UBC; PSMC6; PSMC1; PSMB6; PSMD11; PSMB3; PSMD3; PSMA7; PSMD8
R-HSA-69017	CDK-mediated phosphorylation and removal of Cdc6	4.17	1.17e-06	1.30e-05	15/53	PSMD6; PSMD2; PSMB1; PSMC2; PSMB7; PSMD13; UBC; PSMC6; PSMC1; PSMB6; PSMD11; PSMB3; PSMD3; PSMA7; PSMD8
R-HSA-69202	Cyclin E associated events during G1/S transition	4.14	5.72e-07	7.35e-06	16/57	CKS1B; PSMD6; PSMD2; PSMB1; PSMC2; PSMB7; PSMD13; UBC; PSMC6; PSMC1; PSMB6; PSMD11; PSMB3; PSMD3; PSMA7; PSMD8
R-HSA-69656	Cyclin A:Cdk2-associated events at S phase entry	4.14	5.72e-07	7.35e-06	16/57	CKS1B; PSMD6; PSMD2; PSMB1; PSMC2; PSMB7; PSMD13; UBC; PSMC6; PSMC1; PSMB6; PSMD11; PSMB3; PSMD3; PSMA7; PSMD8
R-HSA-174143	APC/C-mediated degradation of cell cycle proteins	4.14	5.72e-07	7.35e-06	16/57	PSMD6; PSMD2; PTTG1; PSMB1; PSMC2; PSMB7; PSMD13; UBC; PSMC6; PSMC1; PSMB6; PSMD11; PSMB3; PSMD3; PSMA7; PSMD8
R-HSA-453276	Regulation of mitotic cell cycle	4.14	5.72e-07	7.35e-06	16/57	PSMD6; PSMD2; PTTG1; PSMB1; PSMC2; PSMB7; PSMD13; UBC; PSMC6; PSMC1; PSMB6; PSMD11; PSMB3; PSMD3; PSMA7; PSMD8
R-HSA-1234174	Regulation of Hypoxia-inducible Factor (HIF) by oxygen	4.14	5.72e-07	7.35e-06	16/57	PSMD6; PSMD2; PSMB1; PSMC2; PSMB7; PSMD13; UBC; PSMC6; PSMC1; PSMB6; PSMD11; PSMB3; PSMD3; PSMA7; PSMD8; EGLN2
R-HSA-2262749	Cellular response to hypoxia	4.14	5.72e-07	7.35e-06	16/57	PSMD6; PSMD2; PSMB1; PSMC2; PSMB7; PSMD13; UBC; PSMC6; PSMC1; PSMB6; PSMD11; PSMB3; PSMD3; PSMA7; PSMD8; EGLN2
R-HSA-174184	Cdc20:Phospho-APC/C mediated degradation of Cyclin A	4.10	1.52e-06	1.64e-05	15/54	PSMD6; PSMD2; PSMB1; PSMC2; PSMB7; PSMD13; UBC; PSMC6; PSMC1; PSMB6; PSMD11; PSMB3; PSMD3; PSMA7; PSMD8
R-HSA-179419	APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint	4.10	1.52e-06	1.64e-05	15/54	PSMD6; PSMD2; PSMB1; PSMC2; PSMB7; PSMD13; UBC; PSMC6; PSMC1; PSMB6; PSMD11; PSMB3; PSMD3; PSMA7; PSMD8
R-HSA-5626467	RHO GTPases activate IQGAPs	4.10	5.67e-03	3.00e-02	5/18	ACTB; TUBA1A; CALM1; ACTG1
R-HSA-163210	Formation of ATP by chemiosmotic coupling	4.10	5.67e-03	3.00e-02	5/18	ATP5G3; ATP5B; ATP5A1; ATP5E; ATP5O
R-HSA-983705	Signaling by the B Cell Receptor (BCR)	4.08	1.37e-07	3.51e-06	18/65	PSMD6; PSMD2; PSMB1; PSMC2; PSMB7; PSMD13; UBC; PSMC6; PSMC1; CALM1; PSMB6; PSMD11; PSMB3; PSMD3; FKBP1A; PSMA7; PSMD8
R-HSA-195253	Degradation of beta-catenin by the destruction complex	4.04	3.63e-07	5.58e-06	17/62	PSMD6; PSMD2; PPP2CA; PSMB1; PSMC2; PSMB7; PSMD13; UBC; PSMC6; PSMC1; PSMB6; PSMD11; PSMB3; PSMD3; PSMA7; PSMD8; PPP2R1A
R-HSA-8948751	Regulation of PTEN stability and activity	4.02	1.96e-06	1.99e-05	15/55	PSMD6; PSMD2; PSMB1; PSMC2; PSMB7; PSMD13; UBC; PSMC6; PSMC1; PSMB6; PSMD11; PSMB3; PSMD3; PSMA7; PSMD8
R-HSA-9020702	Interleukin-1 signaling	4.00	9.58e-07	1.09e-05	16/59	PSMD6; PSMD2; PSMB1; PSMC2; PSMB7; PSMD13; UBC; HMGB1; PSMC6; PSMC1; PSMB6; PSMD11; PSMB3; PSMD3; PSMA7; PSMD8
R-HSA-382556	ABC-family proteins mediated transport	3.95	2.52e-06	2.46e-05	15/56	PSMD6; PSMD2; PSMB1; PSMC2; PSMB7; PSMD13; UBC; PSMC6; PSMC1; PSMB6; PSMD11; PSMB3; PSMD3; PSMA7; PSMD8
R-HSA-176408	Regulation of APC/C activators between G1/S and early anaphase	3.95	2.52e-06	2.46e-05	15/56	PSMD6; PSMD2; PSMB1; PSMC2; PSMB7; PSMD13; UBC; PSMC6; PSMC1; PSMB6; PSMD11; PSMB3; PSMD3; PSMA7; PSMD8
R-HSA-5621481	C-type lectin receptors (CLRs)	3.95	1.11e-07	3.29e-06	19/71	PSMD6; UBA3; PSMD2; PSMB1; PSMC2; PSMB7; PSMD13; UBC; PSMC6; PSMC1; CALM1; PDPK1; PSMB6; PSMD11; PSMB3; PSMD3; PSMA7; PSMD8
R-HSA-202403	TCR signaling	3.87	1.57e-06	1.66e-05	16/61	PSMD6; PSMD2; PSMB1; PSMC2; PSMB7; PSMD13; UBC; PSMC6; PSMC1; PDPK1; PSMB6; PSMD11; PSMB3; PSMD3; PSMA7; PSMD8
R-HSA-9013694	Signaling by NOTCH4	3.81	4.07e-06	3.77e-05	15/58	PSMD6; PSMD2; PSMB1; PSMC2; PSMB7; PSMD13; UBC; PSMC6; PSMC1; PSMB6; PSMD11; PSMB3; PSMD3; PSMA7; PSMD8
R-HSA-8878159	Transcriptional regulation by RUNX3	3.75	5.14e-06	4.56e-05	15/59	PSMD6; PSMD2; PSMB1; PSMC2; PSMB7; PSMD13; UBC; PSMC6; PSMC1; PSMB6; PSMD11; PSMB3; PSMD3; PSMA7; PSMD8
R-HSA-69052	Switching of origins to a post-replicative state	3.75	5.14e-06	4.56e-05	15/59	PSMD6; PSMD2; PSMB1; PSMC2; PSMB7; PSMD13; UBC; PSMC6; PSMC1; PSMB6; PSMD11; PSMB3; PSMD3; PSMA7; PSMD8
R-HSA-4086400	PCP/CE pathway	3.74	2.50e-06	2.46e-05	16/63	PSMD6; AP2M1; PSMD2; PSMB1; PSMC2; PSMB7; PSMD13; UBC; PSMC6; PSMC1; PSMB6; PSMD11; PSMB3; PSMD3; PSMA7; PSMD8
R-HSA-69206	G1/S Transition	3.74	5.90e-07	7.47e-06	18/71	CKS1B; PSMD6; PSMD2; PPP2CA; PSMB1; PSMC2; PSMB7; PSMD13; UBC; PSMC6; PSMC1; PSMB6; PSMD11; PSMB3; PSMD3; PSMA7; PSMD8; PPP2R1A
R-HSA-450531	Regulation of mRNA stability by proteins that bind AU-rich elements	3.69	1.52e-06	1.64e-05	17/68	PSMD6; PSMD2; PSMB1; HSPB1; PSMC2; PSMB7; PSMD13; HSPA8; UBC; PSMC6; PSMC1; PSMB6; PSMD11; PSMB3; PSMD3; PSMA7; PSMD8
R-HSA-351202	Metabolism of polyamines	3.69	1.32e-05	1.08e-04	14/56	PSMD6; PSMD2; PSMB1; PSMC2; PSMB7; PSMD13; PSMC6; PSMC1; PSMB6; PSMD11; PSMB3; PSMD3; PSMA7; PSMD8
R-HSA-5687128	MAPK6/MAPK4 signaling	3.63	3.91e-06	3.66e-05	16/65	PSMD6; PSMD2; PSMB1; HSPB1; PSMC2; PSMB7; PSMD13; UBC; PSMC6; PSMC1; PSMB6; PSMD11; PSMB3; PSMD3; PSMA7; PSMD8
R-HSA-446652	Interleukin-1 family signaling	3.57	4.85e-06	4.40e-05	16/66	PSMD6; PSMD2; PSMB1; PSMC2; PSMB7; PSMD13; UBC; HMGB1; PSMC6; PSMC1; PSMB6; PSMD11; PSMB3; PSMD3; PSMA7; PSMD8
R-HSA-163200	Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.	3.49	3.79e-09	1.48e-06	27/114	NDUFS2; COX5B; ATP5G3; SDHA; NDUFS6; COX7C; NDUFB11; NDUFS8; NDUFC2; SDHD; ATP5B; NDUFA12; COX6A1; NDUFB10; TRAP1; UQCRC2; NDUFAB1; ATP5A1; ATP5E; ATP5O; MT-ND1; MT-ND2; MT-CO1; MT-CO2; MT-CO3; MT-ND4; MT-CYB
R-HSA-453279	Mitotic G1-G1/S phases	3.49	1.75e-06	1.82e-05	18/76	CKS1B; PSMD6; PSMD2; PPP2CA; PSMB1; PSMC2; PSMB7; PSMD13; UBC; PSMC6; PSMC1; PSMB6; PSMD11; PSMB3; PSMD3; PSMA7; PSMD8; PPP2R1A
R-HSA-8949613	Cristae formation	3.44	3.19e-03	1.78e-02	7/30	ATP5G3; CHCHD3; ATP5B; ATP5A1; ATP5E; SAMM50; ATP5O
R-HSA-5610787	Hedgehog 'off' state	3.42	9.01e-06	7.65e-05	16/69	PSMD6; PSMD2; PSMB1; PSMC2; PSMB7; PSMD13; TUBA1A; UBC; PSMC6; PSMC1; PSMB6; PSMD11; PSMB3; PSMD3; PSMA7; PSMD8
R-HSA-5689603	UCH proteinases	3.42	9.01e-06	7.65e-05	16/69	PSMD6; PSMD2; PSMB1; ACTB; PSMC2; PSMB7; PSMD13; UBC; PSMC6; PSMC1; PSMB6; PSMD11; PSMB3; PSMD3; PSMA7; PSMD8
R-HSA-611105	Respiratory electron transport	3.41	1.79e-07	4.06e-06	22/95	NDUFS2; COX5B; SDHA; NDUFS6; COX7C; NDUFB11; NDUFS8; NDUFC2; SDHD; NDUFA12; COX6A1; NDUFB10; TRAP1; UQCRC2; NDUFAB1; MT-ND1; MT-ND2; MT-CO1; MT-CO2; MT-CO3; MT-ND4; MT-CYB
R-HSA-69481	G2/M Checkpoints	3.40	2.62e-06	2.53e-05	18/78	YWHAQ; PSMD6; PSMD2; HIST1H4C; PSMB1; PSMC2; PSMB7; PSMD13; KAT5; UBC; PSMC6; PSMC1; PSMB6; PSMD11; PSMB3; PSMD3; PSMA7; PSMD8
R-HSA-2454202	Fc epsilon receptor (FCERI) signaling	3.36	3.19e-06	3.02e-05	18/79	PSMD6; PSMD2; PSMB1; PSMC2; PSMB7; PSMD13; UBC; PSMC6; PSMC1; CALM1; PDPK1; PSMB6; PSMD11; PSMB3; PSMD3; PSMA7; PSMD8
R-HSA-8878166	Transcriptional regulation by RUNX2	3.35	2.24e-05	1.77e-04	15/66	PSMD6; PSMD2; PSMB1; PSMC2; PSMB7; PSMD13; UBC; PSMC6; PSMC1; PSMB6; PSMD11; PSMB3; PSMD3; PSMA7; PSMD8
R-HSA-69239	Synthesis of DNA	3.35	2.24e-05	1.77e-04	15/66	PSMD6; PSMD2; PSMB1; PSMC2; PSMB7; PSMD13; UBC; PSMC6; PSMC1; PSMB6; PSMD11; PSMB3; PSMD3; PSMA7; PSMD8
R-HSA-3858494	Beta-catenin independent WNT signaling	3.26	2.76e-06	2.64e-05	19/86	PSMD6; AP2M1; PSMD2; PSMB1; PSMC2; PSMB7; PSMD13; GNG3; UBC; PSMC6; PSMC1; CALM1; PSMB6; PSMD11; PSMB3; PSMD3; PSMA7; PSMD8
R-HSA-69306	DNA Replication	3.21	3.94e-05	3.00e-04	15/69	PSMD6; PSMD2; PSMB1; PSMC2; PSMB7; PSMD13; UBC; PSMC6; PSMC1; PSMB6; PSMD11; PSMB3; PSMD3; PSMA7; PSMD8
R-HSA-3371497	HSP90 chaperone cycle for steroid hormone receptors (SHR)	3.19	2.74e-03	1.56e-02	8/37	HSP90AB1; CAPZA2; DCTN3; HSPA8; TUBA1A; DCTN2; ACTR10; HSP90AA1
R-HSA-69275	G2/M Transition	3.14	7.85e-08	3.22e-06	26/122	CENPF; PSMD6; PSMD2; PPP2CA; TUBB; HSP90AB1; PSMB1; PSMC2; DCTN3; PSMB7; PSMD13; TUBA1A; DCTN2; PHLDA1; UBC; PSMC6; PSMC1; HSP90AA1; PSMB6; PSMD11; PSMB3; PSMD3; PSMA7; RAB8A; PSMD8; PPP2R1A
R-HSA-6799198	Complex I biogenesis	3.12	5.55e-04	3.47e-03	11/52	NDUFS2; NDUFS6; NDUFB11; NDUFS8; NDUFC2; NDUFA12; NDUFB10; NDUFAB1; MT-ND1; MT-ND2; MT-ND4
R-HSA-453274	Mitotic G2-G2/M phases	3.12	9.37e-08	3.24e-06	26/123	CENPF; PSMD6; PSMD2; PPP2CA; TUBB; HSP90AB1; PSMB1; PSMC2; DCTN3; PSMB7; PSMD13; TUBA1A; DCTN2; PHLDA1; UBC; PSMC6; PSMC1; HSP90AA1; PSMB6; PSMD11; PSMB3; PSMD3; PSMA7; RAB8A; PSMD8; PPP2R1A
R-HSA-201681	TCF dependent signaling in response to WNT	3.10	1.95e-06	1.99e-05	21/100	PSMD6; PSMD2; H2AFZ; PPP2CA; SOX4; HIST1H4C; PSMB1; PSMC2; PSMB7; PSMD13; KAT5; UBC; PSMC6; PSMC1; PSMB6; PSMD11; PSMB3; PSMD3; PSMA7; PSMD8; PPP2R1A
R-HSA-1428517	The citric acid (TCA) cycle and respiratory electron transport	3.09	1.06e-08	1.82e-06	30/143	NDUFS2; FH; COX5B; ATP5G3; PDHB; SDHA; NDUFS6; COX7C; NDUFB11; NDUFS8; NDUFC2; SDHD; ATP5B; NDUFA12; COX6A1; SUCLA2; NDUFB10; TRAP1; UQCRC2; NDUFAB1; ATP5A1; ATP5E; ATP5O; MT-ND1; MT-ND2; MT-CO1; MT-CO2; MT-CO3; MT-ND4; MT-CYB
R-HSA-162909	Host Interactions of HIV factors	3.05	7.98e-06	7.01e-05	19/92	TPR; ARF1; PSMD6; AP2M1; PSMD2; PSMB1; PSMC2; PSMB7; PSMD13; UBC; PSMC6; PSMC1; PSMB6; PSMD11; PSMB3; PSMD3; RAE1; PSMA7; PSMD8
R-HSA-9010553	Regulation of expression of SLITs and ROBOs	2.97	2.90e-08	2.49e-06	30/149	RPL5; RBM8A; RPL31; PSMD6; PSMD2; RPL34; RPS3A; PSMB1; PSMC2; RPS4X; RPL10; RPL7; PSMB7; PSMD13; RPS24; RPLP0; UBC; RPS29; PSMC6; PSMC1; RNPS1; PSMB6; PSMD11; PSMB3; RPL19; PSMD3; EIF4A3; PSMA7; PSMD8; RPL3
R-HSA-5358351	Signaling by Hedgehog	2.88	8.82e-05	6.33e-04	16/82	PSMD6; PSMD2; PSMB1; PSMC2; PSMB7; PSMD13; TUBA1A; UBC; PSMC6; PSMC1; PSMB6; PSMD11; PSMB3; PSMD3; PSMA7; PSMD8
R-HSA-5673001	RAF/MAP kinase cascade	2.84	8.36e-06	7.27e-05	21/109	PSMD6; PSMD2; PPP2CA; PSMB1; ACTB; PSMC2; PSMB7; PSMD13; UBC; PSMC6; PSMC1; CALM1; PSMB6; PSMD11; PSMB3; PSMD3; ACTG1; PSMA7; PSMD8; PPP2R1A
R-HSA-109581	Apoptosis	2.83	2.43e-05	1.87e-04	19/99	YWHAQ; PSMD6; PSMD2; HMGB2; PSMB1; PSMC2; FNTA; PSMB7; PSMD13; UBC; HMGB1; PSMC6; PSMC1; PSMB6; PSMD11; PSMB3; PSMD3; PSMA7; PSMD8
R-HSA-5357801	Programmed Cell Death	2.83	2.43e-05	1.87e-04	19/99	YWHAQ; PSMD6; PSMD2; HMGB2; PSMB1; PSMC2; FNTA; PSMB7; PSMD13; UBC; HMGB1; PSMC6; PSMC1; PSMB6; PSMD11; PSMB3; PSMD3; PSMA7; PSMD8
R-HSA-5684996	MAPK1/MAPK3 signaling	2.82	9.71e-06	8.12e-05	21/110	PSMD6; PSMD2; PPP2CA; PSMB1; ACTB; PSMC2; PSMB7; PSMD13; UBC; PSMC6; PSMC1; CALM1; PSMB6; PSMD11; PSMB3; PSMD3; ACTG1; PSMA7; PSMD8; PPP2R1A
R-HSA-72649	Translation initiation complex formation	2.68	3.30e-03	1.82e-02	10/55	EIF4A2; EIF4E; RPS3A; RPS4X; EIF3E; RPS24; RPS29; EIF3J; EIF4A1; EIF3D
R-HSA-72702	Ribosomal scanning and start codon recognition	2.68	3.30e-03	1.82e-02	10/55	EIF4A2; EIF4E; RPS3A; RPS4X; EIF3E; RPS24; RPS29; EIF3J; EIF4A1; EIF3D
R-HSA-72662	Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S	2.63	3.78e-03	2.06e-02	10/56	EIF4A2; EIF4E; RPS3A; RPS4X; EIF3E; RPS24; RPS29; EIF3J; EIF4A1; EIF3D
R-HSA-69242	S Phase	2.62	2.77e-04	1.81e-03	16/90	CKS1B; PSMD6; PSMD2; PSMB1; PSMC2; PSMB7; PSMD13; UBC; PSMC6; PSMC1; PSMB6; PSMD11; PSMB3; PSMD3; PSMA7; PSMD8
R-HSA-8951664	Neddylation	2.61	1.36e-05	1.11e-04	23/130	PSMD6; UBA3; PSMD2; COPS4; PSMB1; PSMC2; COPS5; DCAF13; PSMB7; PSMD13; UBC; PSMC6; PSMC1; PSMB6; COPS3; PSMD11; PSMB3; PSMD3; PSMA7; FBXL12; KEAP1; PSMD8; FBXO7
R-HSA-157118	Signaling by NOTCH	2.59	8.57e-05	6.20e-04	19/108	PSMD6; PSMD2; H2AFZ; HIST1H4C; PSMB1; PSMC2; PSMB7; PSMD13; UBC; PSMC6; PSMC1; PSMB6; NCOR1; PSMD11; PSMB3; PSMD3; PSMA7; PSMD8; MFNG
R-HSA-2467813	Separation of Sister Chromatids	2.59	5.78e-05	4.29e-04	20/114	CENPF; PSMD6; PSMD2; PPP2CA; PTTG1; PSMB1; PSMC2; PSMB7; PSMD13; TUBA1A; UBC; PSMC6; PSMC1; PSMB6; PSMD11; PSMB3; PSMD3; PSMA7; PSMD8; PPP2R1A
R-HSA-5689880	Ub-specific processing proteases	2.53	2.76e-04	1.81e-03	17/99	PSMD6; PSMD2; PSMB1; PSMC2; PSMB7; PSMD13; SUDS3; UBC; PSMC6; PSMC1; PSMB6; PSMD11; PSMB3; PSMD3; PSMA7; KEAP1; PSMD8
R-HSA-156827	L13a-mediated translational silencing of Ceruloplasmin expression	2.53	1.86e-04	1.26e-03	18/105	RPL5; RPL31; EIF4A2; EIF4E; RPL34; RPS3A; RPS4X; RPL10; RPL7; EIF3E; RPS24; RPLP0; RPS29; EIF3J; EIF4A1; RPL19; EIF3D; RPL3
R-HSA-72706	GTP hydrolysis and joining of the 60S ribosomal subunit	2.50	2.11e-04	1.42e-03	18/106	RPL5; RPL31; EIF4A2; EIF4E; RPL34; RPS3A; RPS4X; RPL10; RPL7; EIF3E; RPS24; RPLP0; RPS29; EIF3J; EIF4A1; RPL19; EIF3D; RPL3
R-HSA-376176	Signaling by ROBO receptors	2.49	1.75e-06	1.82e-05	30/178	RPL5; RBM8A; RPL31; PSMD6; PSMD2; RPL34; RPS3A; PSMB1; PSMC2; RPS4X; RPL10; RPL7; PSMB7; PSMD13; RPS24; RPLP0; UBC; RPS29; PSMC6; PSMC1; RNPS1; PSMB6; PSMD11; PSMB3; RPL19; PSMD3; EIF4A3; PSMA7; PSMD8; RPL3
R-HSA-8878171	Transcriptional regulation by RUNX1	2.48	2.38e-04	1.59e-03	18/107	PSMD6; PSMD2; H2AFZ; HIST1H4C; PSMB1; PSMC2; PSMB7; PSMD13; YAF2; UBC; PSMC6; PSMC1; PSMB6; PSMD11; PSMB3; PSMD3; PSMA7; PSMD8
R-HSA-195721	Signaling by WNT	2.47	1.49e-05	1.20e-04	25/149	PSMD6; AP2M1; PSMD2; H2AFZ; PPP2CA; SOX4; HIST1H4C; PSMB1; PSMC2; PSMB7; PSMD13; GNG3; KAT5; UBC; PSMC6; PSMC1; CALM1; PSMB6; PSMD11; PSMB3; PSMD3; PSMA7; PSMD8; PPP2R1A
R-HSA-5683057	MAPK family signaling cascades	2.44	6.24e-05	4.59e-04	22/133	PSMD6; PSMD2; PPP2CA; PSMB1; ACTB; HSPB1; PSMC2; PSMB7; PSMD13; UBC; PSMC6; PSMC1; CALM1; PSMB6; PSMD11; PSMB3; PSMD3; ACTG1; PSMA7; PSMD8; PPP2R1A
R-HSA-2555396	Mitotic Metaphase and Anaphase	2.44	1.38e-04	9.57e-04	20/121	CENPF; PSMD6; PSMD2; PPP2CA; PTTG1; PSMB1; PSMC2; PSMB7; PSMD13; TUBA1A; UBC; PSMC6; PSMC1; PSMB6; PSMD11; PSMB3; PSMD3; PSMA7; PSMD8; PPP2R1A
R-HSA-68882	Mitotic Anaphase	2.44	1.38e-04	9.57e-04	20/121	CENPF; PSMD6; PSMD2; PPP2CA; PTTG1; PSMB1; PSMC2; PSMB7; PSMD13; TUBA1A; UBC; PSMC6; PSMC1; PSMB6; PSMD11; PSMB3; PSMD3; PSMA7; PSMD8; PPP2R1A
R-HSA-1592230	Mitochondrial biogenesis	2.42	7.10e-03	3.68e-02	10/61	ATP5G3; CHCHD3; ATP5B; CALM1; NCOR1; ATP5A1; ATP5E; SAMM50; ATP5O
R-HSA-449147	Signaling by Interleukins	2.41	2.39e-05	1.87e-04	25/153	ARF1; PSMD6; PSMD2; PPP2CA; TCP1; PSMB1; STX1A; PSMC2; PSMB7; PSMD13; HSPA8; RPLP0; UBC; HMGB1; PSMC6; PSMC1; HSP90AA1; PSMB6; PSMD11; PSMB3; PSMD3; PSMA7; JUNB; PSMD8; PPP2R1A
R-HSA-927802	Nonsense-Mediated Decay (NMD)	2.39	5.66e-04	3.48e-03	17/105	RPL5; RBM8A; RPL31; RPL34; RPS3A; PPP2CA; RPS4X; RPL10; RPL7; RPS24; RPLP0; RPS29; RNPS1; RPL19; EIF4A3; PPP2R1A; RPL3
R-HSA-975957	Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)	2.39	5.66e-04	3.48e-03	17/105	RPL5; RBM8A; RPL31; RPL34; RPS3A; PPP2CA; RPS4X; RPL10; RPL7; RPS24; RPLP0; RPS29; RNPS1; RPL19; EIF4A3; PPP2R1A; RPL3
R-HSA-72613	Eukaryotic Translation Initiation	2.35	4.79e-04	3.01e-03	18/113	RPL5; RPL31; EIF4A2; EIF4E; RPL34; RPS3A; RPS4X; RPL10; RPL7; EIF3E; RPS24; RPLP0; RPS29; EIF3J; EIF4A1; RPL19; EIF3D; RPL3
R-HSA-72737	Cap-dependent Translation Initiation	2.35	4.79e-04	3.01e-03	18/113	RPL5; RPL31; EIF4A2; EIF4E; RPL34; RPS3A; RPS4X; RPL10; RPL7; EIF3E; RPS24; RPLP0; RPS29; EIF3J; EIF4A1; RPL19; EIF3D; RPL3
R-HSA-72689	Formation of a pool of free 40S subunits	2.33	1.55e-03	9.10e-03	15/95	RPL5; RPL31; RPL34; RPS3A; RPS4X; RPL10; RPL7; EIF3E; RPS24; RPLP0; RPS29; EIF3J; RPL19; EIF3D; RPL3
R-HSA-69620	Cell Cycle Checkpoints	2.32	1.38e-04	9.57e-04	22/140	CENPF; YWHAQ; PCBP4; PSMD6; PSMD2; PPP2CA; HIST1H4C; PSMB1; PSMC2; PSMB7; PSMD13; KAT5; UBC; PSMC6; PSMC1; PSMB6; PSMD11; PSMB3; PSMD3; PSMA7; PSMD8; PPP2R1A
R-HSA-6807070	PTEN Regulation	2.25	1.61e-03	9.35e-03	16/105	PSMD6; PSMD2; PSMB1; PSMC2; MAF1; PSMB7; PSMD13; UBC; PSMC6; PSMC1; PSMB6; PSMD11; PSMB3; PSMD3; PSMA7; PSMD8
R-HSA-1280215	Cytokine Signaling in Immune system	2.23	9.06e-06	7.65e-05	32/212	TPR; ARF1; PSMD6; UBA3; PSMD2; EIF4A2; EIF4E; PPP2CA; TCP1; PSMB1; STX1A; PSMC2; PSMB7; PSMD13; HSPA8; RPLP0; UBC; HMGB1; PSMC6; PSMC1; HSP90AA1; PSMB6; EIF4A1; PSMD11; PSMB3; PSMD3; EIF4A3; RAE1; PSMA7; JUNB; PSMD8; PPP2R1A
R-HSA-2262752	Cellular responses to stress	2.14	1.09e-05	9.02e-05	34/234	TPR; PSMD6; PSMD2; H2AFZ; HIST1H4C; HSP90AB1; PSMB1; PSMC2; CAPZA2; HSF1; DCTN3; PSMB7; PSMD13; KAT5; GSTP1; HSPA8; PRDX3; TUBA1A; DCTN2; UBC; PSMC6; ACTR10; PSMC1; HSP90AA1; TERF2IP; PSMB6; PSMD11; PSMB3; PSMD3; RAE1; PSMA7; PRDX2; PSMD8; EGLN2
R-HSA-192823	Viral mRNA Translation	2.13	9.25e-03	4.74e-02	12/83	RPL5; RPL31; RPL34; RPS3A; RPS4X; RPL10; RPL7; RPS24; RPLP0; RPS29; RPL19; RPL3
R-HSA-71291	Metabolism of amino acids and derivatives	2.12	4.81e-05	3.64e-04	30/209	RPL5; RPL31; PDHB; PSMD6; PSMD2; RPL34; RPS3A; PSMB1; PSMC2; RPS4X; RPL10; RPL7; PSMB7; PSMD13; SLC3A2; RPS24; RPLP0; RPS29; PSMC6; PSMC1; NDUFAB1; PSMB6; PSMD11; PSMB3; RPL19; PSMD3; PSMA7; PSMD8; MPST; RPL3
R-HSA-68886	M Phase	2.10	7.80e-05	5.69e-04	29/204	TPR; CENPF; PSMD6; PSMD2; H2AFZ; PPP2CA; PTTG1; HIST1H4C; TUBB; PSMB1; PSMC2; RAB2A; DCTN3; PSMB7; PSMD13; TUBA1A; DCTN2; UBC; PSMC6; PSMC1; HSP90AA1; PSMB6; PSMD11; PSMB3; PSMD3; RAE1; PSMA7; PSMD8; PPP2R1A
R-HSA-5663205	Infectious disease	2.09	4.12e-06	3.78e-05	39/275	RPL5; TPR; ARF1; RPL31; PSMD6; AP2M1; PSMD2; RPL34; RPS3A; HSP90AB1; PSMB1; STX1A; TAF6; PSMC2; RPS4X; RPL10; RPL7; PSMB7; PSMD13; RPS24; RPLP0; UBC; RPS29; PSMC6; PSMC1; CALM1; HSP90AA1; POLR2C; PSMB6; PSMD11; PSMB3; RPL19; PSMD3; RAE1; NELFCD; PSMA7; PSMD8; RPL3
R-HSA-168273	Influenza Viral RNA Transcription and Replication	2.09	3.48e-03	1.91e-02	16/113	RPL5; TPR; RPL31; RPL34; RPS3A; RPS4X; RPL10; RPL7; RPS24; RPLP0; RPS29; HSP90AA1; POLR2C; RPL19; RAE1; RPL3
R-HSA-162906	HIV Infection	2.05	7.98e-04	4.80e-03	22/158	TPR; ARF1; PSMD6; AP2M1; PSMD2; PSMB1; TAF6; PSMC2; PSMB7; PSMD13; UBC; PSMC6; PSMC1; POLR2C; PSMB6; PSMD11; PSMB3; PSMD3; RAE1; NELFCD; PSMA7; PSMD8
R-HSA-9006925	Intracellular signaling by second messengers	2.04	1.16e-03	6.91e-03	21/152	PSMD6; PSMD2; PPP2CA; PSMB1; PSMC2; MAF1; PSMB7; PSMD13; UBC; PSMC6; PSMC1; CALM1; PDPK1; PSMB6; PSMD11; PSMB3; PSMD3; PSMA7; PSMD8; PPP2R1A
R-HSA-1257604	PIP3 activates AKT signaling	2.00	2.46e-03	1.41e-02	19/140	PSMD6; PSMD2; PPP2CA; PSMB1; PSMC2; MAF1; PSMB7; PSMD13; UBC; PSMC6; PSMC1; PDPK1; PSMB6; PSMD11; PSMB3; PSMD3; PSMA7; PSMD8; PPP2R1A

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Factor 6 : 2 significant Reactome pathways

GeneSet	description	enrichRatio	pValue	FDR	GeneRatio	geneSymbols
R-HSA-983170	Antigen Presentation: Folding, assembly and peptide loading of class I MHC	14.10	1.26e-05	0.0108	5/11	CANX; HLA-A; HSPA5; PDIA3; CALR
R-HSA-168255	Influenza Life Cycle	3.34	1.06e-04	0.0457	13/121	RPS7; RPL22L1; CANX; RPS18; RPL10A; RPS20; RPL12; RPS25; RAN; HSP90AA1; RPS21; CALR; RPS9

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Factor 7 : 54 significant Reactome pathways

GeneSet	description	enrichRatio	pValue	FDR	GeneRatio	geneSymbols
R-HSA-156902	Peptide chain elongation	7.87	0.00e+00	0.00e+00	57/84	RPL11; RPS8; RPL5; RPS27; RPS27A; RPL37A; RPL32; RPL15; RPSA; RPL29; RPL22L1; RPL9; RPL34; RPS3A; RPL37; RPS23; RPS14; RPS18; RPL10A; EEF1A1; RPS12; RPS4X; RPL39; RPL10; RPS20; RPL7; RPL30; RPS6; RPL35; RPL7A; RPL27A; RPS13; RPS3; RPS24; RPS26; RPL41; RPL6; RPLP0; RPL21; RPS29; RPL36AL; RPL4; RPS17; RPS2; RPS15A; RPL13; RPL26; RPL23A; RPL23; RPL19; EEF2; RPL18A; RPS19; RPL18; RPL13A; RPS11; RPL3
R-HSA-156842	Eukaryotic Translation Elongation	7.69	0.00e+00	0.00e+00	57/86	RPL11; RPS8; RPL5; RPS27; RPS27A; RPL37A; RPL32; RPL15; RPSA; RPL29; RPL22L1; RPL9; RPL34; RPS3A; RPL37; RPS23; RPS14; RPS18; RPL10A; EEF1A1; RPS12; RPS4X; RPL39; RPL10; RPS20; RPL7; RPL30; RPS6; RPL35; RPL7A; RPL27A; RPS13; RPS3; RPS24; RPS26; RPL41; RPL6; RPLP0; RPL21; RPS29; RPL36AL; RPL4; RPS17; RPS2; RPS15A; RPL13; RPL26; RPL23A; RPL23; RPL19; EEF2; RPL18A; RPS19; RPL18; RPL13A; RPS11; RPL3
R-HSA-192823	Viral mRNA Translation	7.69	0.00e+00	0.00e+00	55/83	RPL11; RPS8; RPL5; RPS27; RPS27A; RPL37A; RPL32; RPL15; RPSA; RPL29; RPL22L1; RPL9; RPL34; RPS3A; RPL37; RPS23; RPS14; RPS18; RPL10A; RPS12; RPS4X; RPL39; RPL10; RPS20; RPL7; RPL30; RPS6; RPL35; RPL7A; RPL27A; RPS13; RPS3; RPS24; RPS26; RPL41; RPL6; RPLP0; RPL21; RPS29; RPL36AL; RPL4; RPS17; RPS2; RPS15A; RPL13; RPL26; RPL23A; RPL23; RPL19; RPL18A; RPS19; RPL18; RPL13A; RPS11; RPL3
R-HSA-72764	Eukaryotic Translation Termination	7.56	0.00e+00	0.00e+00	56/86	RPL11; RPS8; RPL5; RPS27; RPS27A; RPL37A; RPL32; RPL15; RPSA; RPL29; RPL22L1; RPL9; RPL34; RPS3A; RPL37; RPS23; RPS14; RPS18; RPL10A; RPS12; RPS4X; RPL39; RPL10; RPS20; RPL7; RPL30; RPS6; RPL35; RPL7A; RPL27A; RPS13; TRMT112; RPS3; RPS24; RPS26; RPL41; RPL6; RPLP0; RPL21; RPS29; RPL36AL; RPL4; RPS17; RPS2; RPS15A; RPL13; RPL26; RPL23A; RPL23; RPL19; RPL18A; RPS19; RPL18; RPL13A; RPS11; RPL3
R-HSA-2408557	Selenocysteine synthesis	7.51	0.00e+00	0.00e+00	55/85	RPL11; RPS8; RPL5; RPS27; RPS27A; RPL37A; RPL32; RPL15; RPSA; RPL29; RPL22L1; RPL9; RPL34; RPS3A; RPL37; RPS23; RPS14; RPS18; RPL10A; RPS12; RPS4X; RPL39; RPL10; RPS20; RPL7; RPL30; RPS6; RPL35; RPL7A; RPL27A; RPS13; RPS3; RPS24; RPS26; RPL41; RPL6; RPLP0; RPL21; RPS29; RPL36AL; RPL4; RPS17; RPS2; RPS15A; RPL13; RPL26; RPL23A; RPL23; RPL19; RPL18A; RPS19; RPL18; RPL13A; RPS11; RPL3
R-HSA-72689	Formation of a pool of free 40S subunits	7.45	0.00e+00	0.00e+00	61/95	RPL11; RPS8; RPL5; RPS27; RPS27A; RPL37A; RPL32; RPL15; RPSA; RPL29; RPL22L1; RPL9; RPL34; RPS3A; RPL37; RPS23; RPS14; RPS18; RPL10A; RPS12; RPS4X; RPL39; RPL10; RPS20; RPL7; RPL30; EIF3E; EIF3H; RPS6; RPL35; RPL7A; EIF3F; RPL27A; RPS13; RPS3; RPS24; RPS26; RPL41; RPL6; RPLP0; RPL21; RPS29; RPL36AL; EIF3J; RPL4; RPS17; RPS2; RPS15A; RPL13; RPL26; RPL23A; RPL23; RPL19; RPL18A; EIF3K; RPS19; RPL18; RPL13A; RPS11; EIF3L; RPL3
R-HSA-975956	Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)	7.25	0.00e+00	0.00e+00	55/88	RPL11; RPS8; RPL5; RPS27; RPS27A; RPL37A; RPL32; RPL15; RPSA; RPL29; RPL22L1; RPL9; RPL34; RPS3A; RPL37; RPS23; RPS14; RPS18; RPL10A; RPS12; RPS4X; RPL39; RPL10; RPS20; RPL7; RPL30; RPS6; RPL35; RPL7A; RPL27A; RPS13; RPS3; RPS24; RPS26; RPL41; RPL6; RPLP0; RPL21; RPS29; RPL36AL; RPL4; RPS17; RPS2; RPS15A; RPL13; RPL26; RPL23A; RPL23; RPL19; RPL18A; RPS19; RPL18; RPL13A; RPS11; RPL3
R-HSA-163210	Formation of ATP by chemiosmotic coupling	7.09	3.01e-08	6.65e-07	11/18	ATP5G3; ATP5I; ATP5J2; ATP5L; ATP5G2; ATP5G1; ATP5H; ATP5A1; ATP5E; ATP5J; ATP5O
R-HSA-156827	L13a-mediated translational silencing of Ceruloplasmin expression	6.85	0.00e+00	0.00e+00	62/105	RPL11; RPS8; RPL5; RPS27; RPS27A; RPL37A; RPL32; RPL15; RPSA; RPL29; RPL22L1; EIF4A2; RPL9; RPL34; RPS3A; RPL37; RPS23; RPS14; RPS18; RPL10A; RPS12; RPS4X; RPL39; RPL10; RPS20; RPL7; RPL30; EIF3E; EIF3H; RPS6; RPL35; RPL7A; EIF3F; RPL27A; RPS13; RPS3; RPS24; RPS26; RPL41; RPL6; RPLP0; RPL21; RPS29; RPL36AL; EIF3J; RPL4; RPS17; RPS2; RPS15A; RPL13; RPL26; RPL23A; RPL23; RPL19; RPL18A; EIF3K; RPS19; RPL18; RPL13A; RPS11; EIF3L; RPL3
R-HSA-72706	GTP hydrolysis and joining of the 60S ribosomal subunit	6.79	0.00e+00	0.00e+00	62/106	RPL11; RPS8; RPL5; RPS27; RPS27A; RPL37A; RPL32; RPL15; RPSA; RPL29; RPL22L1; EIF4A2; RPL9; RPL34; RPS3A; RPL37; RPS23; RPS14; RPS18; RPL10A; RPS12; RPS4X; RPL39; RPL10; RPS20; RPL7; RPL30; EIF3E; EIF3H; RPS6; RPL35; RPL7A; EIF3F; RPL27A; RPS13; RPS3; RPS24; RPS26; RPL41; RPL6; RPLP0; RPL21; RPS29; RPL36AL; EIF3J; RPL4; RPS17; RPS2; RPS15A; RPL13; RPL26; RPL23A; RPL23; RPL19; RPL18A; EIF3K; RPS19; RPL18; RPL13A; RPS11; EIF3L; RPL3
R-HSA-72695	Formation of the ternary complex, and subsequently, the 43S complex	6.77	0.00e+00	0.00e+00	28/48	RPS8; RPS27; RPS27A; RPSA; RPS3A; RPS23; RPS14; RPS18; RPS12; RPS4X; RPS20; EIF3E; EIF3H; RPS6; EIF3F; RPS13; RPS3; RPS24; RPS26; RPS29; EIF3J; RPS17; RPS2; RPS15A; EIF3K; RPS19; RPS11; EIF3L
R-HSA-8876725	Protein methylation	6.77	1.79e-05	3.58e-04	7/12	CALM2; EEF1A1; CALM1; RPS2; EEF2; CALM3; ETFB
R-HSA-1799339	SRP-dependent cotranslational protein targeting to membrane	6.69	0.00e+00	0.00e+00	60/104	RPL11; RPS8; RPL5; RPS27; RPS27A; RPL37A; RPL32; RPL15; RPSA; RPL29; SPCS1; RPL22L1; RPL9; RPL34; RPS3A; RPL37; RPS23; RPS14; RPS18; RPL10A; RPS12; SEC61G; RPS4X; RPL39; SSR4; RPL10; RPS20; RPL7; RPL30; RPS6; SEC61B; RPL35; RPL7A; RPL27A; RPS13; RPS3; RPS24; RPS26; RPL41; RPL6; RPLP0; RPL21; RPS29; RPL36AL; SRP14; RPL4; RPS17; RPS2; RPS15A; RPL13; RPL26; RPL23A; RPL23; RPL19; RPL18A; RPS19; RPL18; RPL13A; RPS11; RPL3
R-HSA-72613	Eukaryotic Translation Initiation	6.47	0.00e+00	0.00e+00	63/113	RPL11; RPS8; RPL5; RPS27; RPS27A; RPL37A; RPL32; RPL15; RPSA; RPL29; RPL22L1; EIF4A2; RPL9; RPL34; RPS3A; RPL37; RPS23; RPS14; RPS18; RPL10A; RPS12; RPS4X; RPL39; RPL10; EIF4EBP1; RPS20; RPL7; RPL30; EIF3E; EIF3H; RPS6; RPL35; RPL7A; EIF3F; RPL27A; RPS13; RPS3; RPS24; RPS26; RPL41; RPL6; RPLP0; RPL21; RPS29; RPL36AL; EIF3J; RPL4; RPS17; RPS2; RPS15A; RPL13; RPL26; RPL23A; RPL23; RPL19; RPL18A; EIF3K; RPS19; RPL18; RPL13A; RPS11; EIF3L; RPL3
R-HSA-72737	Cap-dependent Translation Initiation	6.47	0.00e+00	0.00e+00	63/113	RPL11; RPS8; RPL5; RPS27; RPS27A; RPL37A; RPL32; RPL15; RPSA; RPL29; RPL22L1; EIF4A2; RPL9; RPL34; RPS3A; RPL37; RPS23; RPS14; RPS18; RPL10A; RPS12; RPS4X; RPL39; RPL10; EIF4EBP1; RPS20; RPL7; RPL30; EIF3E; EIF3H; RPS6; RPL35; RPL7A; EIF3F; RPL27A; RPS13; RPS3; RPS24; RPS26; RPL41; RPL6; RPLP0; RPL21; RPS29; RPL36AL; EIF3J; RPL4; RPS17; RPS2; RPS15A; RPL13; RPL26; RPL23A; RPL23; RPL19; RPL18A; EIF3K; RPS19; RPL18; RPL13A; RPS11; EIF3L; RPL3
R-HSA-2408522	Selenoamino acid metabolism	6.45	0.00e+00	0.00e+00	55/99	RPL11; RPS8; RPL5; RPS27; RPS27A; RPL37A; RPL32; RPL15; RPSA; RPL29; RPL22L1; RPL9; RPL34; RPS3A; RPL37; RPS23; RPS14; RPS18; RPL10A; RPS12; RPS4X; RPL39; RPL10; RPS20; RPL7; RPL30; RPS6; RPL35; RPL7A; RPL27A; RPS13; RPS3; RPS24; RPS26; RPL41; RPL6; RPLP0; RPL21; RPS29; RPL36AL; RPL4; RPS17; RPS2; RPS15A; RPL13; RPL26; RPL23A; RPL23; RPL19; RPL18A; RPS19; RPL18; RPL13A; RPS11; RPL3
R-HSA-168273	Influenza Viral RNA Transcription and Replication	6.26	0.00e+00	0.00e+00	61/113	RPL11; RPS8; RPL5; RPS27; RPS27A; RPL37A; RPL32; RPL15; RPSA; RPL29; RPL22L1; RPL9; RPL34; RPS3A; RPL37; RPS23; RPS14; RPS18; RPL10A; RPS12; POLR2J; RPS4X; RPL39; RPL10; RPS20; RPL7; RPL30; POLR2K; RPS6; RPL35; RPL7A; POLR2L; RPL27A; RPS13; RPS3; RPS24; RPS26; RPL41; RPL6; RPLP0; RPL21; RPS29; RPL36AL; HSP90AA1; RPL4; RPS17; RPS2; RPS15A; RPL13; RPL26; RPL23A; RPL23; RPL19; RPL18A; POLR2I; RPS19; RPL18; RPL13A; RPS11; POLR2F; RPL3
R-HSA-72662	Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S	6.22	0.00e+00	0.00e+00	30/56	RPS8; RPS27; RPS27A; RPSA; EIF4A2; RPS3A; RPS23; RPS14; RPS18; RPS12; RPS4X; EIF4EBP1; RPS20; EIF3E; EIF3H; RPS6; EIF3F; RPS13; RPS3; RPS24; RPS26; RPS29; EIF3J; RPS17; RPS2; RPS15A; EIF3K; RPS19; RPS11; EIF3L
R-HSA-72649	Translation initiation complex formation	6.12	0.00e+00	0.00e+00	29/55	RPS8; RPS27; RPS27A; RPSA; EIF4A2; RPS3A; RPS23; RPS14; RPS18; RPS12; RPS4X; RPS20; EIF3E; EIF3H; RPS6; EIF3F; RPS13; RPS3; RPS24; RPS26; RPS29; EIF3J; RPS17; RPS2; RPS15A; EIF3K; RPS19; RPS11; EIF3L
R-HSA-72702	Ribosomal scanning and start codon recognition	6.12	0.00e+00	0.00e+00	29/55	RPS8; RPS27; RPS27A; RPSA; EIF4A2; RPS3A; RPS23; RPS14; RPS18; RPS12; RPS4X; RPS20; EIF3E; EIF3H; RPS6; EIF3F; RPS13; RPS3; RPS24; RPS26; RPS29; EIF3J; RPS17; RPS2; RPS15A; EIF3K; RPS19; RPS11; EIF3L
R-HSA-927802	Nonsense-Mediated Decay (NMD)	6.08	0.00e+00	0.00e+00	55/105	RPL11; RPS8; RPL5; RPS27; RPS27A; RPL37A; RPL32; RPL15; RPSA; RPL29; RPL22L1; RPL9; RPL34; RPS3A; RPL37; RPS23; RPS14; RPS18; RPL10A; RPS12; RPS4X; RPL39; RPL10; RPS20; RPL7; RPL30; RPS6; RPL35; RPL7A; RPL27A; RPS13; RPS3; RPS24; RPS26; RPL41; RPL6; RPLP0; RPL21; RPS29; RPL36AL; RPL4; RPS17; RPS2; RPS15A; RPL13; RPL26; RPL23A; RPL23; RPL19; RPL18A; RPS19; RPL18; RPL13A; RPS11; RPL3
R-HSA-975957	Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)	6.08	0.00e+00	0.00e+00	55/105	RPL11; RPS8; RPL5; RPS27; RPS27A; RPL37A; RPL32; RPL15; RPSA; RPL29; RPL22L1; RPL9; RPL34; RPS3A; RPL37; RPS23; RPS14; RPS18; RPL10A; RPS12; RPS4X; RPL39; RPL10; RPS20; RPL7; RPL30; RPS6; RPL35; RPL7A; RPL27A; RPS13; RPS3; RPS24; RPS26; RPL41; RPL6; RPLP0; RPL21; RPS29; RPL36AL; RPL4; RPS17; RPS2; RPS15A; RPL13; RPL26; RPL23A; RPL23; RPL19; RPL18A; RPS19; RPL18; RPL13A; RPS11; RPL3
R-HSA-6799198	Complex I biogenesis	6.02	4.44e-16	1.09e-14	27/52	NDUFS5; NDUFB3; NDUFAF3; NDUFB4; NDUFC1; NDUFS6; NDUFA2; NDUFB2; NDUFB11; NDUFA1; NDUFB9; NDUFB6; NDUFS8; NDUFC2; NDUFB8; NDUFB1; NDUFB10; NDUFAB1; NDUFS7; NDUFA11; NDUFA7; NDUFB7; NDUFA13; NDUFA3; NDUFA6; MT-ND3; MT-ND4
R-HSA-163200	Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.	6.01	0.00e+00	0.00e+00	59/114	NDUFS5; UQCRH; COX20; COX5B; ATP5G3; NDUFB3; NDUFAF3; NDUFB4; ATP5I; NDUFC1; NDUFS6; COX7C; UQCRQ; NDUFA2; NDUFA4; CYCS; ATP5J2; NDUFB2; NDUFB11; COX7B; NDUFA1; UQCRB; COX6C; NDUFB9; NDUFB6; COX8A; NDUFS8; NDUFC2; ATP5L; NDUFB8; COX14; ATP5G2; COX6A1; COX16; NDUFB1; COX5A; NDUFB10; NDUFAB1; COX4I1; ATP5G1; ATP5H; ATP5A1; ATP5E; NDUFS7; UQCR11; NDUFA11; NDUFA7; NDUFB7; NDUFA13; COX6B1; ETFB; NDUFA3; UQCR10; NDUFA6; ATP5J; ATP5O; MT-CO1; MT-ND3; MT-ND4
R-HSA-168255	Influenza Life Cycle	5.95	0.00e+00	0.00e+00	62/121	RPL11; RPS8; RPL5; RPS27; RPS27A; RPL37A; RPL32; RPL15; RPSA; RPL29; RPL22L1; RPL9; RPL34; RPS3A; RPL37; RPS23; RPS14; RPS18; RPL10A; RPS12; POLR2J; RPS4X; RPL39; RPL10; RPS20; RPL7; RPL30; POLR2K; RPS6; RPL35; RPL7A; POLR2L; RPL27A; RPS13; RPS3; RPS24; RPS26; RPL41; RPL6; RPLP0; RAN; RPL21; RPS29; RPL36AL; HSP90AA1; RPL4; RPS17; RPS2; RPS15A; RPL13; RPL26; RPL23A; RPL23; RPL19; RPL18A; POLR2I; RPS19; RPL18; RPL13A; RPS11; POLR2F; RPL3
R-HSA-611105	Respiratory electron transport	5.86	0.00e+00	0.00e+00	48/95	NDUFS5; UQCRH; COX20; COX5B; NDUFB3; NDUFAF3; NDUFB4; NDUFC1; NDUFS6; COX7C; UQCRQ; NDUFA2; NDUFA4; CYCS; NDUFB2; NDUFB11; COX7B; NDUFA1; UQCRB; COX6C; NDUFB9; NDUFB6; COX8A; NDUFS8; NDUFC2; NDUFB8; COX14; COX6A1; COX16; NDUFB1; COX5A; NDUFB10; NDUFAB1; COX4I1; NDUFS7; UQCR11; NDUFA11; NDUFA7; NDUFB7; NDUFA13; COX6B1; ETFB; NDUFA3; UQCR10; NDUFA6; MT-CO1; MT-ND3; MT-ND4
R-HSA-3299685	Detoxification of Reactive Oxygen Species	5.80	5.65e-06	1.19e-04	9/18	PRDX1; GPX1; ATOX1; CYCS; TXN; PRDX5; GSTP1; PRDX2; SOD1
R-HSA-168254	Influenza Infection	5.71	0.00e+00	0.00e+00	63/128	RPL11; RPS8; RPL5; RPS27; RPS27A; RPL37A; RPL32; RPL15; RPSA; RPL29; RPL22L1; RPL9; RPL34; RPS3A; RPL37; RPS23; RPS14; RPS18; RPL10A; RPS12; POLR2J; SLC25A6; RPS4X; RPL39; RPL10; RPS20; RPL7; RPL30; POLR2K; RPS6; RPL35; RPL7A; POLR2L; RPL27A; RPS13; RPS3; RPS24; RPS26; RPL41; RPL6; RPLP0; RAN; RPL21; RPS29; RPL36AL; HSP90AA1; RPL4; RPS17; RPS2; RPS15A; RPL13; RPL26; RPL23A; RPL23; RPL19; RPL18A; POLR2I; RPS19; RPL18; RPL13A; RPS11; POLR2F; RPL3
R-HSA-5601884	PIWI-interacting RNA (piRNA) biogenesis	5.36	3.98e-04	7.13e-03	6/13	POLR2J; POLR2K; POLR2L; HSP90AA1; POLR2I; POLR2F
R-HSA-3371511	HSF1 activation	5.27	1.38e-03	2.32e-02	5/11	EEF1A1; RPA3; HSP90AA1; HSBP1; YWHAE
R-HSA-430039	mRNA decay by 5' to 3' exoribonuclease	5.27	1.38e-03	2.32e-02	5/11	LSM3; LSM6; LSM5; LSM7; LSM4
R-HSA-9010553	Regulation of expression of SLITs and ROBOs	4.83	0.00e+00	0.00e+00	62/149	RPL11; RPS8; RPL5; RPS27; RPS27A; RPL37A; RPL32; RPL15; RPSA; RPL29; RPL22L1; RPL9; RPL34; RPS3A; RPL37; RPS23; RPS14; RPS18; RPL10A; RPS12; SHFM1; RPS4X; RPL39; RPL10; RPS20; RPL7; TCEB1; RPL30; RPS6; RPL35; RPL7A; RPL27A; RPS13; RPS3; RPS24; RPS26; RPL41; RPL6; RPLP0; UBC; RPL21; RPS29; RPL36AL; RPL4; RPS17; RPS2; TCEB2; RPS15A; RPL13; RPL26; RPL23A; PSMB3; RPL23; RPL19; PSMA7; RPL18A; RPS19; RPL18; RPL13A; RPS11; RPL3; RBX1
R-HSA-1428517	The citric acid (TCA) cycle and respiratory electron transport	4.79	0.00e+00	0.00e+00	59/143	NDUFS5; UQCRH; COX20; COX5B; ATP5G3; NDUFB3; NDUFAF3; NDUFB4; ATP5I; NDUFC1; NDUFS6; COX7C; UQCRQ; NDUFA2; NDUFA4; CYCS; ATP5J2; NDUFB2; NDUFB11; COX7B; NDUFA1; UQCRB; COX6C; NDUFB9; NDUFB6; COX8A; NDUFS8; NDUFC2; ATP5L; NDUFB8; COX14; ATP5G2; COX6A1; COX16; NDUFB1; COX5A; NDUFB10; NDUFAB1; COX4I1; ATP5G1; ATP5H; ATP5A1; ATP5E; NDUFS7; UQCR11; NDUFA11; NDUFA7; NDUFB7; NDUFA13; COX6B1; ETFB; NDUFA3; UQCR10; NDUFA6; ATP5J; ATP5O; MT-CO1; MT-ND3; MT-ND4
R-HSA-8949613	Cristae formation	4.64	2.84e-06	6.10e-05	12/30	MINOS1; ATP5G3; ATP5I; ATP5J2; ATP5L; ATP5G2; ATP5G1; ATP5H; ATP5A1; ATP5E; ATP5J; ATP5O
R-HSA-451326	Activation of kainate receptors upon glutamate binding	4.35	1.48e-03	2.46e-02	6/16	GNG5; CALM2; GNG3; CALM1; CALM3; GNG8
R-HSA-8868773	rRNA processing in the nucleus and cytosol	4.28	0.00e+00	0.00e+00	59/160	RPL11; RPS8; RPL5; RPS27; RPS27A; RPL37A; RPL32; RPL15; RPSA; RPL29; RPL22L1; RPL9; RPL34; RPS3A; RPL37; RPS23; RPS14; NHP2; RPS18; RPL10A; RPS12; RPS4X; RPL39; RPL10; RPS20; RPL7; RPL30; RPS6; RPL35; RPL7A; RPL27A; RPS13; TRMT112; RPS3; RPS24; RPS26; RPL41; RPL6; RPLP0; RPL21; RPS29; RPL36AL; NOP10; RPL4; RPS17; RPS2; RPS15A; RPL13; RPL26; RPL23A; RPL23; RPL19; RPL18A; RPS19; RPL18; RPL13A; RPS11; RPL3; SNU13
R-HSA-72312	rRNA processing	4.25	0.00e+00	0.00e+00	60/164	RPL11; RPS8; RPL5; RPS27; RPS27A; RPL37A; RPL32; RPL15; RPSA; RPL29; RPL22L1; RPL9; RPL34; RPS3A; RPL37; RPS23; RPS14; NHP2; RPS18; RPL10A; RPS12; HSD17B10; RPS4X; RPL39; RPL10; RPS20; RPL7; RPL30; RPS6; RPL35; RPL7A; RPL27A; RPS13; TRMT112; RPS3; RPS24; RPS26; RPL41; RPL6; RPLP0; RPL21; RPS29; RPL36AL; NOP10; RPL4; RPS17; RPS2; RPS15A; RPL13; RPL26; RPL23A; RPL23; RPL19; RPL18A; RPS19; RPL18; RPL13A; RPS11; RPL3; SNU13
R-HSA-5628897	TP53 Regulates Metabolic Genes	4.22	2.60e-10	5.90e-09	24/66	PRDX1; LAMTOR5; LAMTOR2; COX20; COX5B; COX7C; NDUFA4; CYCS; LAMTOR4; COX7B; COX6C; YWHAZ; TXN; COX8A; PRDX5; COX14; COX6A1; COX16; COX5A; COX4I1; YWHAE; PRDX2; COX6B1; MT-CO1
R-HSA-6791226	Major pathway of rRNA processing in the nucleolus and cytosol	4.22	0.00e+00	0.00e+00	56/154	RPL11; RPS8; RPL5; RPS27; RPS27A; RPL37A; RPL32; RPL15; RPSA; RPL29; RPL22L1; RPL9; RPL34; RPS3A; RPL37; RPS23; RPS14; RPS18; RPL10A; RPS12; RPS4X; RPL39; RPL10; RPS20; RPL7; RPL30; RPS6; RPL35; RPL7A; RPL27A; RPS13; RPS3; RPS24; RPS26; RPL41; RPL6; RPLP0; RPL21; RPS29; RPL36AL; RPL4; RPS17; RPS2; RPS15A; RPL13; RPL26; RPL23A; RPL23; RPL19; RPL18A; RPS19; RPL18; RPL13A; RPS11; RPL3; SNU13
R-HSA-376176	Signaling by ROBO receptors	4.11	0.00e+00	0.00e+00	63/178	RPL11; RPS8; RPL5; RPS27; RPS27A; RPL37A; RPL32; RPL15; RPSA; RPL29; RPL22L1; RPL9; RPL34; RPS3A; RPL37; RPS23; RPS14; RPS18; RPL10A; RPS12; SHFM1; RPS4X; RPL39; RPL10; RPS20; RPL7; TCEB1; RPL30; RPS6; RPL35; RPL7A; RPL27A; RPS13; RPS3; RPS24; RPS26; RPL41; RPL6; RPLP0; UBC; RPL21; RPS29; RPL36AL; RPL4; RPS17; RPS2; TCEB2; RPS15A; RPL13; PFN1; RPL26; RPL23A; PSMB3; RPL23; RPL19; PSMA7; RPL18A; RPS19; RPL18; RPL13A; RPS11; RPL3; RBX1
R-HSA-5339562	Uptake and actions of bacterial toxins	4.10	2.13e-03	3.46e-02	6/17	CALM2; CALM1; HSP90AA1; VAMP2; EEF2; CALM3
R-HSA-5626467	RHO GTPases activate IQGAPs	3.87	2.97e-03	4.65e-02	6/18	CALM2; TUBB2B; TUBA1A; CALM1; ACTG1; CALM3
R-HSA-72766	Translation	3.61	0.00e+00	0.00e+00	80/257	AURKAIP1; MRPL20; RPL11; RPS8; RPL5; MRPS21; RPS27; MRPL33; RPS27A; RPL37A; RPL32; RPL15; RPSA; RPL29; SPCS1; RPL22L1; EIF4A2; RPL9; RPL34; RPS3A; RPL37; RPS23; RPS14; RPS18; RPL10A; EEF1A1; RPS12; SEC61G; RPS4X; RPL39; SSR4; RPL10; EIF4EBP1; RPS20; RPL7; RPL30; EIF3E; EIF3H; RPS6; SEC61B; RPL35; RPL7A; MRPL41; EIF3F; RPL27A; RPS13; TRMT112; RPS3; CHCHD1; RPS24; MRPL51; RPS26; RPL41; RPL6; RPLP0; RPL21; MRPL52; RPS29; RPL36AL; SRP14; EIF3J; RPL4; RPS17; RPS2; RPS15A; RPL13; RPL26; RPL23A; RPL23; RPL19; EEF2; RPL18A; EIF3K; RPS19; RPL18; RPL13A; RPS11; EIF3L; RPL3; MRPS6
R-HSA-5663205	Infectious disease	3.50	0.00e+00	0.00e+00	83/275	RPL11; RPS8; RPL5; RPS27; CALM2; RPS27A; RPL37A; RPL32; RPL15; RPSA; RPL29; RPL22L1; RPL9; RPL34; RPS3A; RPL37; RPS23; SKP1; RPS14; RPS18; RPL10A; RPS12; GTF2H5; PPIA; SHFM1; POLR2J; SLC25A6; RPS4X; RPL39; RPL10; RPS20; RPL7; TCEB1; RPL30; POLR2K; RPS6; RPL35; RPL7A; POLR2L; RPL27A; RPS13; BANF1; RPS3; RPS24; RPS26; RPL41; RPL6; RPLP0; UBC; RAN; RPL21; RPS29; RPL36AL; CALM1; HSP90AA1; GTF2A2; RPL4; RPS17; RPS2; TCEB2; RPS15A; RPL13; VAMP2; RPL26; RPL23A; PSMB3; RPL23; RPL19; PSMA7; EEF2; RPL18A; POLR2I; RPS19; CALM3; AP2S1; RPL18; RPL13A; RPS11; CHMP2A; RANBP1; POLR2F; RPL3; RBX1
R-HSA-71291	Metabolism of amino acids and derivatives	3.39	0.00e+00	0.00e+00	61/209	RPL11; RPS8; RPL5; RPS27; RPS27A; RPL37A; RPL32; RPL15; RPSA; RPL29; RPL22L1; RPL9; RPL34; RPS3A; RPL37; RPS23; RPS14; RPS18; RPL10A; RPS12; SHFM1; HSD17B10; RPS4X; RPL39; RPL10; RPS20; RPL7; RPL30; RPS6; RPL35; RPL7A; RPL27A; RPS13; RPS3; RPS24; RPS26; RPL41; RPL6; RPLP0; RPL21; RPS29; RPL36AL; RPL4; RPS17; RPS2; RPS15A; NDUFAB1; RPL13; RPL26; RPL23A; PSMB3; RPL23; RPL19; PSMA7; OAZ1; RPL18A; RPS19; RPL18; RPL13A; RPS11; RPL3
R-HSA-6782210	Gap-filling DNA repair synthesis and ligation in TC-NER	3.27	3.02e-04	5.54e-03	11/39	RPS27A; POLE4; GTF2H5; RPA3; POLR2J; POLR2K; POLR2L; UBC; POLR2I; POLR2F; RBX1
R-HSA-1592230	Mitochondrial biogenesis	3.23	8.25e-06	1.69e-04	17/61	MINOS1; CALM2; ATP5G3; ATP5I; CYCS; ATP5J2; SSBP1; ATP5L; ATP5G2; CALM1; ATP5G1; ATP5H; ATP5A1; ATP5E; CALM3; ATP5J; ATP5O
R-HSA-72165	mRNA Splicing - Minor Pathway	3.19	6.35e-05	1.24e-03	14/51	SNRPE; SF3B6; SNRPG; SF3B5; POLR2J; POLR2K; POLR2L; SF3B2; SNRPF; SNRPD1; POLR2I; SNRPD2; POLR2F; SNU13
R-HSA-6782135	Dual incision in TC-NER	3.11	4.87e-04	8.56e-03	11/41	RPS27A; POLE4; GTF2H5; RPA3; POLR2J; POLR2K; POLR2L; UBC; POLR2I; POLR2F; RBX1
R-HSA-422475	Axon guidance	2.65	0.00e+00	0.00e+00	75/328	RPL11; RPS8; RPL5; RPS27; RPS27A; RPL37A; RPL32; RPL15; RPSA; RPL29; GAP43; RPL22L1; RPL9; RPL34; RPS3A; RPL37; RPS23; RPS14; TUBB2B; RPS18; RPL10A; CD24; RPS12; SHFM1; RPS4X; RPL39; RPL10; DPYSL2; RPS20; RPL7; TCEB1; RPL30; RPS6; RPL35; RPL7A; RPL27A; RPS13; CFL1; RPS3; RPS24; TUBA1A; RPS26; RPL41; MYL6; RPL6; RPLP0; UBC; RPL21; RPS29; RPL36AL; HSP90AA1; RPL4; RPS17; RPS2; TCEB2; RPS15A; RPL13; PFN1; RPL26; RPL23A; PSMB3; RPL23; RPL19; ACTG1; MYL12B; PSMA7; RPL18A; PSENEN; RPS19; AP2S1; RPL18; RPL13A; RPS11; RPL3; RBX1
R-HSA-6781827	Transcription-Coupled Nucleotide Excision Repair (TC-NER)	2.55	2.85e-03	4.54e-02	11/50	RPS27A; POLE4; GTF2H5; RPA3; POLR2J; POLR2K; POLR2L; UBC; POLR2I; POLR2F; RBX1
R-HSA-1643685	Disease	2.25	1.55e-15	3.72e-14	90/464	RPL11; RPS8; PRDX1; RPL5; RPS27; CALM2; RPS27A; RPL37A; RPL32; RPL15; RPSA; RPL29; RPL22L1; RPL9; RPL34; RPS3A; RPL37; RPS23; SKP1; RPS14; RPS18; RPL10A; RPS12; GTF2H5; PPIA; SHFM1; POLR2J; SLC25A6; RPS4X; RPL39; RPL10; RPS20; RPL7; TCEB1; RPL30; POLR2K; RPS6; RPL35; RPL7A; POLR2L; RPL27A; RPS13; BANF1; RPS3; RPS24; RPS26; RPL41; RPL6; PEBP1; RPLP0; UBC; RAN; RPL21; RPS29; RPL36AL; CALM1; HSP90AA1; GTF2A2; RPL4; RPS17; RPS2; TCEB2; RPS15A; RPL13; YWHAE; VAMP2; RPL26; RPL23A; PSMB3; RPL23; RPL19; PHB; ACTG1; PSMA7; EEF2; PRDX2; RPL18A; PSENEN; POLR2I; RPS19; CALM3; AP2S1; RPL18; RPL13A; RPS11; CHMP2A; RANBP1; POLR2F; RPL3; RBX1
R-HSA-1266738	Developmental Biology	2.14	9.52e-13	2.22e-11	82/445	RPL11; RPS8; RPL5; RPS27; H3F3A; RPS27A; RPL37A; RPL32; RPL15; RPSA; RPL29; GAP43; RPL22L1; RPL9; H2AFZ; RPL34; RPS3A; RPL37; RPS23; RPS14; TUBB2B; RPS18; RPL10A; CD24; RPS12; SHFM1; POLR2J; RPS4X; RPL39; RPL10; DPYSL2; RPS20; RPL7; TCEB1; RPL30; POLR2K; RPS6; RPL35; RPL7A; POLR2L; RPL27A; RPS13; CFL1; RPS3; RPS24; TUBA1A; RPS26; RPL41; MYL6; RPL6; RPLP0; UBC; RPL21; RPS29; RPL36AL; HSP90AA1; RPL4; RPS17; RPS2; TCEB2; RPS15A; RPL13; PFN1; RPL26; RPL23A; PSMB3; RPL23; RPL19; ACTG1; MYL12B; PSMA7; RPL18A; PSENEN; POLR2I; RPS19; AP2S1; RPL18; RPL13A; RPS11; POLR2F; RPL3; RBX1
R-HSA-1852241	Organelle biogenesis and maintenance	2.01	1.52e-04	2.84e-03	29/167	MINOS1; HSPB11; CALM2; DYNC1I2; ATP5G3; TCTEX1D2; ATP5I; TUBB2B; TUBB; CYCS; ATP5J2; SSBP1; DCTN3; ATP5L; TUBA1A; ATP5G2; DCTN2; DYNLL1; CALM1; HSP90AA1; YWHAE; ATP5G1; ATP5H; ATP5A1; DYNLRB1; ATP5E; CALM3; ATP5J; ATP5O

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Factor 8 : 37 significant Reactome pathways

GeneSet	description	enrichRatio	pValue	FDR	GeneRatio	geneSymbols
R-HSA-445355	Smooth Muscle Contraction	9.34	3.79e-06	1.26e-04	7/17	CALM2; ANXA6; TPM2; MYL6B; MYL6; CALM1
R-HSA-2514856	The phototransduction cascade	9.07	6.20e-04	1.54e-02	4/10	CALM2; METAP2; CALM1
R-HSA-2514859	Inactivation, recovery and regulation of the phototransduction cascade	9.07	6.20e-04	1.54e-02	4/10	CALM2; METAP2; CALM1
R-HSA-5218921	VEGFR2 mediated cell proliferation	9.07	6.20e-04	1.54e-02	4/10	CALM2; KRAS; CALM1
R-HSA-5576892	Phase 0 - rapid depolarisation	7.56	1.36e-03	3.26e-02	4/12	CALM2; CACNB3; CALM1
R-HSA-451326	Activation of kainate receptors upon glutamate binding	7.09	4.59e-04	1.28e-02	5/16	GNG4; CALM2; CALM1; GNG8
R-HSA-5339562	Uptake and actions of bacterial toxins	6.67	6.28e-04	1.54e-02	5/17	CALM2; SYT1; CALM1; VAMP2
R-HSA-192823	Viral mRNA Translation	6.01	2.38e-12	9.01e-10	22/83	RPL32; RPL24; RPL34; RPS18; RPL36A; RPL10; RPL8; RPL12; RPL27A; RPS13; RPS3; RPS26; RPL41; RPL6; RPLP0; RPS17; RPL13; RPL26; RPL23A; RPL23; RPL36; RPL28
R-HSA-156902	Peptide chain elongation	5.94	3.11e-12	9.01e-10	22/84	RPL32; RPL24; RPL34; RPS18; RPL36A; RPL10; RPL8; RPL12; RPL27A; RPS13; RPS3; RPS26; RPL41; RPL6; RPLP0; RPS17; RPL13; RPL26; RPL23A; RPL23; RPL36; RPL28
R-HSA-2408557	Selenocysteine synthesis	5.87	4.04e-12	9.01e-10	22/85	RPL32; RPL24; RPL34; RPS18; RPL36A; RPL10; RPL8; RPL12; RPL27A; RPS13; RPS3; RPS26; RPL41; RPL6; RPLP0; RPS17; RPL13; RPL26; RPL23A; RPL23; RPL36; RPL28
R-HSA-156842	Eukaryotic Translation Elongation	5.80	5.23e-12	9.01e-10	22/86	RPL32; RPL24; RPL34; RPS18; RPL36A; RPL10; RPL8; RPL12; RPL27A; RPS13; RPS3; RPS26; RPL41; RPL6; RPLP0; RPS17; RPL13; RPL26; RPL23A; RPL23; RPL36; RPL28
R-HSA-72764	Eukaryotic Translation Termination	5.80	5.23e-12	9.01e-10	22/86	RPL32; RPL24; RPL34; RPS18; RPL36A; RPL10; RPL8; RPL12; RPL27A; RPS13; RPS3; RPS26; RPL41; RPL6; RPLP0; RPS17; RPL13; RPL26; RPL23A; RPL23; RPL36; RPL28
R-HSA-975956	Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)	5.67	8.66e-12	1.24e-09	22/88	RPL32; RPL24; RPL34; RPS18; RPL36A; RPL10; RPL8; RPL12; RPL27A; RPS13; RPS3; RPS26; RPL41; RPL6; RPLP0; RPS17; RPL13; RPL26; RPL23A; RPL23; RPL36; RPL28
R-HSA-2408522	Selenoamino acid metabolism	5.27	1.45e-11	1.79e-09	23/99	RPL32; RPL24; RPL34; RPS18; RPL36A; RPL10; RPL8; RPL12; RPL27A; RPS13; RPS3; RPS26; RPL41; MARS; RPL6; RPLP0; RPS17; RPL13; RPL26; RPL23A; RPL23; RPL36; RPL28
R-HSA-72689	Formation of a pool of free 40S subunits	5.25	4.51e-11	4.59e-09	22/95	RPL32; RPL24; RPL34; RPS18; RPL36A; RPL10; RPL8; RPL12; RPL27A; RPS13; RPS3; RPS26; RPL41; RPL6; RPLP0; RPS17; RPL13; RPL26; RPL23A; RPL23; RPL36; RPL28
R-HSA-927802	Nonsense-Mediated Decay (NMD)	4.97	5.33e-11	4.59e-09	23/105	RPL32; RPL24; RPL34; RPS18; RPL36A; RPL10; RPL8; RPL12; RPL27A; RPS13; RPS3; MAGOHB; RPS26; RPL41; RPL6; RPLP0; RPS17; RPL13; RPL26; RPL23A; RPL23; RPL36; RPL28
R-HSA-975957	Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)	4.97	5.33e-11	4.59e-09	23/105	RPL32; RPL24; RPL34; RPS18; RPL36A; RPL10; RPL8; RPL12; RPL27A; RPS13; RPS3; MAGOHB; RPS26; RPL41; RPL6; RPLP0; RPS17; RPL13; RPL26; RPL23A; RPL23; RPL36; RPL28
R-HSA-1799339	SRP-dependent cotranslational protein targeting to membrane	4.80	3.01e-10	2.36e-08	22/104	RPL32; RPL24; RPL34; RPS18; RPL36A; RPL10; RPL8; RPL12; RPL27A; RPS13; RPS3; RPS26; RPL41; RPL6; RPLP0; RPS17; RPL13; RPL26; RPL23A; RPL23; RPL36; RPL28
R-HSA-156827	L13a-mediated translational silencing of Ceruloplasmin expression	4.75	3.67e-10	2.63e-08	22/105	RPL32; RPL24; RPL34; RPS18; RPL36A; RPL10; RPL8; RPL12; RPL27A; RPS13; RPS3; RPS26; RPL41; RPL6; RPLP0; RPS17; RPL13; RPL26; RPL23A; RPL23; RPL36; RPL28
R-HSA-72706	GTP hydrolysis and joining of the 60S ribosomal subunit	4.71	4.46e-10	2.96e-08	22/106	RPL32; RPL24; RPL34; RPS18; RPL36A; RPL10; RPL8; RPL12; RPL27A; RPS13; RPS3; RPS26; RPL41; RPL6; RPLP0; RPS17; RPL13; RPL26; RPL23A; RPL23; RPL36; RPL28
R-HSA-418346	Platelet homeostasis	4.54	1.64e-03	3.72e-02	6/30	GNG4; CALM2; ATP2B1; CALM1; GNG8
R-HSA-72613	Eukaryotic Translation Initiation	4.42	1.63e-09	7.82e-08	22/113	RPL32; RPL24; RPL34; RPS18; RPL36A; RPL10; RPL8; RPL12; RPL27A; RPS13; RPS3; RPS26; RPL41; RPL6; RPLP0; RPS17; RPL13; RPL26; RPL23A; RPL23; RPL36; RPL28
R-HSA-72737	Cap-dependent Translation Initiation	4.42	1.63e-09	7.82e-08	22/113	RPL32; RPL24; RPL34; RPS18; RPL36A; RPL10; RPL8; RPL12; RPL27A; RPS13; RPS3; RPS26; RPL41; RPL6; RPLP0; RPS17; RPL13; RPL26; RPL23A; RPL23; RPL36; RPL28
R-HSA-168273	Influenza Viral RNA Transcription and Replication	4.42	1.63e-09	7.82e-08	22/113	RPL32; RPL24; RPL34; RPS18; RPL36A; RPL10; RPL8; RPL12; RPL27A; RPS13; RPS3; RPS26; RPL41; RPL6; RPLP0; RPS17; RPL13; RPL26; RPL23A; RPL23; RPL36; RPL28
R-HSA-422356	Regulation of insulin secretion	4.39	1.96e-03	4.33e-02	6/31	GNG4; MARCKS; SLC25A6; CACNB3; VAMP2; GNG8
R-HSA-168255	Influenza Life Cycle	4.31	1.10e-09	6.32e-08	23/121	RPL32; RPL24; RPL34; RPS18; RPL36A; RPL10; RPL8; RPL12; RPL27A; RPS13; RPS3; RPS26; RPL41; RPL6; RPLP0; RAN; RPS17; RPL13; RPL26; RPL23A; RPL23; RPL36; RPL28
R-HSA-168254	Influenza Infection	4.25	6.16e-10	3.79e-08	24/128	RPL32; RPL24; RPL34; RPS18; SLC25A6; RPL36A; RPL10; RPL8; RPL12; RPL27A; RPS13; RPS3; RPS26; RPL41; RPL6; RPLP0; RAN; RPS17; RPL13; RPL26; RPL23A; RPL23; RPL36; RPL28
R-HSA-397014	Muscle contraction	4.12	1.09e-04	3.14e-03	10/55	CALM2; ANXA6; TPM2; KCNIP2; CACNB3; MYL6B; MYL6; ATP2B1; CALM1
R-HSA-9010553	Regulation of expression of SLITs and ROBOs	3.65	1.51e-08	6.85e-07	24/149	RPL32; RPL24; RPL34; RPS18; RPL36A; RPL10; RPL8; RPL12; RPL27A; RPS13; RPS3; MAGOHB; RPS26; RPL41; RPL6; RPLP0; MSI1; RPS17; RPL13; RPL26; RPL23A; RPL23; RPL36; RPL28
R-HSA-376176	Signaling by ROBO receptors	3.31	2.94e-08	1.26e-06	26/178	RPL32; RPL24; RPL34; RPS18; RPL36A; RPL10; RPL8; RPL12; RPL27A; RPS13; RPS3; MAGOHB; RPS26; RPL41; SRGAP1; RPL6; RPLP0; MSI1; RPS17; RPL13; RPL26; RPL23A; RPL23; DCC; RPL36; RPL28
R-HSA-6791226	Major pathway of rRNA processing in the nucleolus and cytosol	3.24	5.78e-07	2.37e-05	22/154	RPL32; RPL24; RPL34; RPS18; RPL36A; RPL10; RPL8; RPL12; RPL27A; RPS13; RPS3; RPS26; RPL41; RPL6; RPLP0; RPS17; RPL13; RPL26; RPL23A; RPL23; RPL36; RPL28
R-HSA-8868773	rRNA processing in the nucleus and cytosol	3.12	1.14e-06	4.07e-05	22/160	RPL32; RPL24; RPL34; RPS18; RPL36A; RPL10; RPL8; RPL12; RPL27A; RPS13; RPS3; RPS26; RPL41; RPL6; RPLP0; RPS17; RPL13; RPL26; RPL23A; RPL23; RPL36; RPL28
R-HSA-72312	rRNA processing	3.04	1.74e-06	6.01e-05	22/164	RPL32; RPL24; RPL34; RPS18; RPL36A; RPL10; RPL8; RPL12; RPL27A; RPS13; RPS3; RPS26; RPL41; RPL6; RPLP0; RPS17; RPL13; RPL26; RPL23A; RPL23; RPL36; RPL28
R-HSA-71291	Metabolism of amino acids and derivatives	2.82	8.01e-07	3.13e-05	26/209	RPL32; RPL24; RPL34; CDO1; RPS18; RPL36A; RPL10; RPL8; RPL12; RPL27A; RPS13; RPS3; BCAT1; RPS26; RPL41; MARS; RPL6; RPLP0; CKB; RPS17; RPL13; RPL26; RPL23A; RPL23; RPL36; RPL28
R-HSA-5663205	Infectious disease	2.39	5.53e-06	1.76e-04	29/275	CALM2; RPL32; RPL24; RPL34; RPS18; SLC25A6; RPL36A; RPL10; RPL8; RPL12; RPL27A; RPS13; RPS3; RPS26; RPL41; SYT1; RPL6; RPLP0; RAN; CALM1; RPS17; RPL13; VAMP2; RPL26; RPL23A; RPL23; RPL36; RPL28
R-HSA-422475	Axon guidance	2.35	1.07e-06	4.01e-05	34/328	RPL32; RPL24; RPL34; RPS18; RPL36A; RPL10; PTK2; RPL8; RPL12; RPL27A; RPS13; RPS3; MAGOHB; KRAS; COL2A1; CACNB3; TUBA1B; RPS26; RPL41; MYL6; SRGAP1; ARPC3; RPL6; RPLP0; MSI1; RPS17; RPL13; RPL26; RPL23A; RPL23; DCC; RPL36; NCAN; RPL28
R-HSA-72766	Translation	2.30	3.84e-05	1.18e-03	26/257	RPL32; RPL24; RPL34; RPS18; RPL36A; RPL10; RPL8; RPL12; RPL27A; RPS13; RPS3; MRPL51; RPS26; RPL41; MARS; TSFM; MRPL42; RPL6; RPLP0; RPS17; RPL13; RPL26; RPL23A; RPL23; RPL36; RPL28

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Factor 9 : 36 significant Reactome pathways

GeneSet	description	enrichRatio	pValue	FDR	GeneRatio	geneSymbols
R-HSA-390522	Striated Muscle Contraction	9.19	5.90e-04	0.02539	4/10	TPM2; ACTC1; TNNC2; TPM4
R-HSA-5626467	RHO GTPases activate IQGAPs	8.94	5.48e-06	0.00157	7/18	TUBA4A; CTNNB1; ACTB; TUBA1B; CALM1; ACTG1; CALM3
R-HSA-373076	Class A/1 (Rhodopsin-like receptors)	8.36	8.96e-04	0.03085	4/11	SST; GAL; NMB; SSTR2
R-HSA-2871809	FCERI mediated Ca+2 mobilization	8.36	8.96e-04	0.03085	4/11	SHC1; VAV2; CALM1; CALM3
R-HSA-445355	Smooth Muscle Contraction	8.11	5.12e-05	0.00722	6/17	TPM2; VCL; MYL6; CALM1; TPM4; CALM3
R-HSA-418990	Adherens junctions interactions	7.66	1.30e-03	0.03726	4/12	CTNNB1; ACTB; CADM1; ACTG1
R-HSA-5576892	Phase 0 - rapid depolarisation	7.66	1.30e-03	0.03726	4/12	CAMK2D; CACNA2D1; CALM1; CALM3
R-HSA-375170	CDO in myogenesis	7.07	1.81e-03	0.04459	4/13	CTNNB1; MEF2C; TCF12; TCF4
R-HSA-525793	Myogenesis	7.07	1.81e-03	0.04459	4/13	CTNNB1; MEF2C; TCF12; TCF4
R-HSA-190828	Gap junction trafficking	6.38	7.91e-04	0.02959	5/18	TUBA4A; ACTB; DNM1; TUBA1B; ACTG1
R-HSA-6794361	Neurexins and neuroligins	6.27	2.57e-04	0.01847	6/22	EPB41; NRXN1; SYT7; SYT1; EPB41L3; HOMER3
R-HSA-157858	Gap junction trafficking and regulation	6.05	1.04e-03	0.03245	5/19	TUBA4A; ACTB; DNM1; TUBA1B; ACTG1
R-HSA-5578775	Ion homeostasis	5.99	3.36e-04	0.02066	6/23	CAMK2D; FXYD6; ATP2B1; CALM1; FXYD1; CALM3
R-HSA-500792	GPCR ligand binding	5.96	1.10e-04	0.00945	7/27	GNG5; SST; GAL; NMB; SSTR2; GNG8; PTH2
R-HSA-936837	Ion transport by P-type ATPases	5.75	4.32e-04	0.02188	6/24	CAMK2D; FXYD6; ATP2B1; CALM1; FXYD1; CALM3
R-HSA-4086398	Ca2+ pathway	5.75	4.32e-04	0.02188	6/24	GNG5; CTNNB1; PRKG2; CALM1; CALM3; GNG8
R-HSA-446728	Cell junction organization	5.52	5.48e-04	0.02539	6/25	CTNNB1; ACTB; ILK; CADM1; RSU1; ACTG1
R-HSA-5218920	VEGFR2 mediated vascular permeability	5.47	1.69e-03	0.04459	5/21	CTNNB1; VAV2; CALM1; CALM3; PRR5
R-HSA-397014	Muscle contraction	5.43	3.60e-07	0.00031	13/55	CAMK2D; CACNA2D1; TPM2; FXYD6; VCL; MYL6; ATP2B1; CALM1; ACTC1; TNNC2; TPM4; FXYD1; CALM3
R-HSA-8986944	Transcriptional Regulation by MECP2	5.19	2.81e-04	0.01858	7/31	SST; CAMK2D; GRIA2; MEF2C; HDAC2; CALM1; CALM3
R-HSA-114608	Platelet degranulation	4.81	7.00e-05	0.00722	9/43	TUBA4A; WDR1; SPARC; TMSB4X; CFL1; VCL; CALM1; PFN1; CALM3
R-HSA-76005	Response to elevated platelet cytosolic Ca2+	4.81	7.00e-05	0.00722	9/43	TUBA4A; WDR1; SPARC; TMSB4X; CFL1; VCL; CALM1; PFN1; CALM3
R-HSA-5576891	Cardiac conduction	4.60	6.19e-04	0.02540	7/35	CAMK2D; CACNA2D1; FXYD6; ATP2B1; CALM1; FXYD1; CALM3
R-HSA-418346	Platelet homeostasis	4.60	1.53e-03	0.04262	6/30	GNG5; PRKG2; ATP2B1; CALM1; CALM3; GNG8
R-HSA-1500931	Cell-Cell communication	4.23	1.04e-03	0.03245	7/38	CTNNB1; CD47; ACTB; ILK; CADM1; RSU1; ACTG1
R-HSA-112314	Neurotransmitter receptors and postsynaptic signal transmission	3.75	1.06e-03	0.03245	8/49	GNG5; CHRNA1; CAMK2D; GRIA2; TSPAN7; CALM1; CALM3; GNG8
R-HSA-373760	L1CAM interactions	3.72	1.33e-04	0.01038	11/68	CNTN2; TUBA4A; ALCAM; ANK2; ACTB; DNM1; VAV2; NCAM1; ANK3; TUBA1B; ACTG1
R-HSA-76002	Platelet activation, signaling and aggregation	3.43	7.55e-05	0.00722	13/87	GNG5; SHC1; TUBA4A; WDR1; SPARC; TMSB4X; VAV2; CFL1; VCL; CALM1; PFN1; CALM3; GNG8
R-HSA-194138	Signaling by VEGF	3.40	2.02e-03	0.04710	8/54	CTNNB1; ACTB; VAV2; PGF; CALM1; ACTG1; CALM3; PRR5
R-HSA-112316	Neuronal System	3.22	4.49e-05	0.00722	15/107	EPB41; GNG5; NRXN1; CHRNA1; CAMK2D; GRIA2; CACNA2D1; TSPAN7; SYT7; SYT1; CALM1; EPB41L3; HOMER3; CALM3; GNG8
R-HSA-418594	G alpha (i) signalling events	3.18	1.75e-03	0.04459	9/65	GNG5; RGS16; RBP1; SST; GAL; CALM1; SSTR2; CALM3; GNG8
R-HSA-388396	GPCR downstream signalling	2.77	4.14e-04	0.02188	14/116	GNG5; RHOC; RGS16; RBP1; SST; VAV2; GAL; CALM1; NMB; SSTR2; PREX1; CALM3; GNG8; PTH2
R-HSA-109582	Hemostasis	2.71	1.96e-05	0.00422	21/178	GNG5; SHC1; GYPC; TUBA4A; CD47; WDR1; PRKG2; SPARC; HDAC2; ACTB; TMSB4X; TSPAN7; VAV2; CFL1; VCL; TUBA1B; ATP2B1; CALM1; PFN1; CALM3; GNG8
R-HSA-372790	Signaling by GPCR	2.68	5.88e-04	0.02539	14/120	GNG5; RHOC; RGS16; RBP1; SST; VAV2; GAL; CALM1; NMB; SSTR2; PREX1; CALM3; GNG8; PTH2
R-HSA-194315	Signaling by Rho GTPases	2.16	1.89e-03	0.04524	17/181	RHOC; ARPC5; TUBA4A; SRGAP3; CTNNB1; FAM13A; ACTB; VAV2; CFL1; TUBA1B; MYL6; DYNLL1; CALM1; PFN1; ACTG1; PREX1; CALM3
R-HSA-1266738	Developmental Biology	2.07	2.93e-06	0.00126	40/445	JUN; RHOC; SHC1; PBX1; ARPC5; LHX9; CNTN2; NCOA1; PKP4; NEUROD1; RPL37A; TUBA4A; SRGAP3; CTNNB1; ROBO1; ALCAM; ANK2; MEF2C; RGMB; DPYSL3; EBF1; PDLIM7; CAP2; ACTB; DNM1; VAV2; CFL1; RPS3; NCAM1; ANK3; TUBA1B; MYL6; TCF12; PFN1; ADAM11; ACTG1; DCC; TCF4; INSM1; LGI4

---

Factor 11 : 62 significant Reactome pathways

GeneSet	description	enrichRatio	pValue	FDR	GeneRatio	geneSymbols
R-HSA-381033	ATF6 (ATF6-alpha) activates chaperones	17.70	5.11e-04	1.18e-02	3/10	DDIT3; XBP1; ATF4
R-HSA-427359	SIRT1 negatively regulates rRNA expression	14.70	9.14e-04	1.87e-02	3/12	H2AFZ; HIST1H4C; HIST1H2AC
R-HSA-5334118	DNA methylation	14.70	9.14e-04	1.87e-02	3/12	H2AFZ; HIST1H4C; HIST1H2AC
R-HSA-73728	RNA Polymerase I Promoter Opening	14.70	9.14e-04	1.87e-02	3/12	H2AFZ; HIST1H4C; HIST1H2AC
R-HSA-171306	Packaging Of Telomere Ends	13.60	1.17e-03	2.20e-02	3/13	H2AFZ; HIST1H4C; HIST1H2AC
R-HSA-5625886	Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3	13.60	1.17e-03	2.20e-02	3/13	H2AFZ; HIST1H4C; HIST1H2AC
R-HSA-389977	Post-chaperonin tubulin folding pathway	13.60	1.17e-03	2.20e-02	3/13	TUBB2A; TUBB2B; TUBA1A
R-HSA-190828	Gap junction trafficking	13.10	1.91e-04	4.85e-03	4/18	TUBB2A; TUBB2B; ACTB; TUBA1A
R-HSA-5626467	RHO GTPases activate IQGAPs	13.10	1.91e-04	4.85e-03	4/18	TUBB2A; TUBB2B; ACTB; TUBA1A
R-HSA-8955332	Carboxyterminal post-translational modifications of tubulin	12.60	1.48e-03	2.49e-02	3/14	TUBB2A; TUBB2B; TUBA1A
R-HSA-157858	Gap junction trafficking and regulation	12.40	2.39e-04	5.89e-03	4/19	TUBB2A; TUBB2B; ACTB; TUBA1A
R-HSA-2299718	Condensation of Prophase Chromosomes	11.10	2.22e-03	3.41e-02	3/16	H2AFZ; HIST1H4C; HIST1H2AC
R-HSA-389960	Formation of tubulin folding intermediates by CCT/TriC	11.10	2.22e-03	3.41e-02	3/16	TUBB2A; TUBB2B; TUBA1A
R-HSA-389957	Prefoldin mediated transfer of substrate to CCT/TriC	10.70	4.35e-04	1.04e-02	4/22	TUBB2A; TUBB2B; ACTB; TUBA1A
R-HSA-912446	Meiotic recombination	10.40	2.66e-03	3.95e-02	3/17	H2AFZ; HIST1H4C; HIST1H2AC
R-HSA-389958	Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding	10.30	5.20e-04	1.18e-02	4/23	TUBB2A; TUBB2B; ACTB; TUBA1A
R-HSA-2408557	Selenocysteine synthesis	9.71	5.08e-11	1.21e-08	14/85	SARS; RPL37A; RPL35A; RPL37; RPS10; RPS12; RPL39; RPL12; RPS24; RPL21; RPS2; RPL27; RPS19; RPS11
R-HSA-192823	Viral mRNA Translation	9.24	5.29e-10	6.51e-08	13/83	RPL37A; RPL35A; RPL37; RPS10; RPS12; RPL39; RPL12; RPS24; RPL21; RPS2; RPL27; RPS19; RPS11
R-HSA-156902	Peptide chain elongation	9.13	6.19e-10	6.66e-08	13/84	RPL37A; RPL35A; RPL37; RPS10; RPS12; RPL39; RPL12; RPS24; RPL21; RPS2; RPL27; RPS19; RPS11
R-HSA-156842	Eukaryotic Translation Elongation	8.92	8.39e-10	7.22e-08	13/86	RPL37A; RPL35A; RPL37; RPS10; RPS12; RPL39; RPL12; RPS24; RPL21; RPS2; RPL27; RPS19; RPS11
R-HSA-72764	Eukaryotic Translation Termination	8.92	8.39e-10	7.22e-08	13/86	RPL37A; RPL35A; RPL37; RPS10; RPS12; RPL39; RPL12; RPS24; RPL21; RPS2; RPL27; RPS19; RPS11
R-HSA-975956	Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)	8.71	1.13e-09	8.09e-08	13/88	RPL37A; RPL35A; RPL37; RPS10; RPS12; RPL39; RPL12; RPS24; RPL21; RPS2; RPL27; RPS19; RPS11
R-HSA-72695	Formation of the ternary complex, and subsequently, the 43S complex	8.60	1.21e-05	3.46e-04	7/48	RPS10; RPS12; RPS24; RPS2; EIF2S2; RPS19; RPS11
R-HSA-72702	Ribosomal scanning and start codon recognition	8.58	2.77e-06	8.51e-05	8/55	RPS10; RPS12; RPS24; EIF5; RPS2; EIF2S2; RPS19; RPS11
R-HSA-72662	Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S	8.43	3.19e-06	9.46e-05	8/56	RPS10; RPS12; EIF4EBP1; RPS24; RPS2; EIF2S2; RPS19; RPS11
R-HSA-72613	Eukaryotic Translation Initiation	8.35	1.86e-11	8.01e-09	16/113	RPL37A; RPL35A; RPL37; RPS10; RPS12; RPL39; EIF4EBP1; RPL12; RPS24; RPL21; EIF5; RPS2; RPL27; EIF2S2; RPS19; RPS11
R-HSA-72737	Cap-dependent Translation Initiation	8.35	1.86e-11	8.01e-09	16/113	RPL37A; RPL35A; RPL37; RPS10; RPS12; RPL39; EIF4EBP1; RPL12; RPS24; RPL21; EIF5; RPS2; RPL27; EIF2S2; RPS19; RPS11
R-HSA-72706	GTP hydrolysis and joining of the 60S ribosomal subunit	8.35	8.98e-11	1.55e-08	15/106	RPL37A; RPL35A; RPL37; RPS10; RPS12; RPL39; RPL12; RPS24; RPL21; EIF5; RPS2; RPL27; EIF2S2; RPS19; RPS11
R-HSA-2408522	Selenoamino acid metabolism	8.34	4.26e-10	6.12e-08	14/99	SARS; RPL37A; RPL35A; RPL37; RPS10; RPS12; RPL39; RPL12; RPS24; RPL21; RPS2; RPL27; RPS19; RPS11
R-HSA-3214858	RMTs methylate histone arginines	8.14	1.29e-03	2.27e-02	4/29	H2AFZ; HIST1H4C; HIST1H2AC; RPS2
R-HSA-437239	Recycling pathway of L1	8.14	1.29e-03	2.27e-02	4/29	TUBB2A; TUBB2B; ACTB; TUBA1A
R-HSA-72689	Formation of a pool of free 40S subunits	8.07	3.00e-09	1.99e-07	13/95	RPL37A; RPL35A; RPL37; RPS10; RPS12; RPL39; RPL12; RPS24; RPL21; RPS2; RPL27; RPS19; RPS11
R-HSA-5250924	B-WICH complex positively regulates rRNA expression	7.86	1.47e-03	2.49e-02	4/30	H2AFZ; HIST1H4C; HIST1H2AC; ACTB
R-HSA-156827	L13a-mediated translational silencing of Ceruloplasmin expression	7.86	9.55e-10	7.48e-08	14/105	RPL37A; RPL35A; RPL37; RPS10; RPS12; RPL39; RPL12; RPS24; RPL21; RPS2; RPL27; EIF2S2; RPS19; RPS11
R-HSA-72649	Translation initiation complex formation	7.51	3.03e-05	8.41e-04	7/55	RPS10; RPS12; RPS24; RPS2; EIF2S2; RPS19; RPS11
R-HSA-1799339	SRP-dependent cotranslational protein targeting to membrane	7.37	9.39e-09	5.69e-07	13/104	RPL37A; RPL35A; RPL37; RPS10; RPS12; RPL39; RPL12; RPS24; RPL21; RPS2; RPL27; RPS19; RPS11
R-HSA-927802	Nonsense-Mediated Decay (NMD)	7.30	1.06e-08	5.69e-07	13/105	RPL37A; RPL35A; RPL37; RPS10; RPS12; RPL39; RPL12; RPS24; RPL21; RPS2; RPL27; RPS19; RPS11
R-HSA-975957	Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)	7.30	1.06e-08	5.69e-07	13/105	RPL37A; RPL35A; RPL37; RPS10; RPS12; RPL39; RPL12; RPS24; RPL21; RPS2; RPL27; RPS19; RPS11
R-HSA-168273	Influenza Viral RNA Transcription and Replication	6.79	2.63e-08	1.26e-06	13/113	RPL37A; RPL35A; RPL37; RPS10; RPS12; RPL39; RPL12; RPS24; RPL21; RPS2; RPL27; RPS19; RPS11
R-HSA-3371497	HSP90 chaperone cycle for steroid hormone receptors (SHR)	6.38	3.25e-03	4.51e-02	4/37	TUBB2A; TUBB2B; TUBA1A; DYNC1H1
R-HSA-6811436	COPI-independent Golgi-to-ER retrograde traffic	6.38	3.25e-03	4.51e-02	4/37	TUBB2A; TUBB2B; TUBA1A; DYNC1H1
R-HSA-168255	Influenza Life Cycle	6.34	6.07e-08	2.75e-06	13/121	RPL37A; RPL35A; RPL37; RPS10; RPS12; RPL39; RPL12; RPS24; RPL21; RPS2; RPL27; RPS19; RPS11
R-HSA-168254	Influenza Infection	5.99	1.20e-07	4.91e-06	13/128	RPL37A; RPL35A; RPL37; RPS10; RPS12; RPL39; RPL12; RPS24; RPL21; RPS2; RPL27; RPS19; RPS11
R-HSA-9010553	Regulation of expression of SLITs and ROBOs	5.94	1.19e-08	6.03e-07	15/149	RPL37A; RPL35A; RPL37; RPS10; RPS12; RPL39; PSMB7; RPL12; RPS24; RPL21; PSMB5; RPS2; RPL27; RPS19; RPS11
R-HSA-71291	Metabolism of amino acids and derivatives	5.64	5.61e-11	1.21e-08	20/209	SARS; PHGDH; RPL37A; RPL35A; RPL37; RPS10; RPS12; RPL39; PSAT1; PSMB7; RPL12; SLC3A2; RPS24; RPL21; PSMB5; RPS2; RPL27; OAZ1; RPS19; RPS11
R-HSA-380320	Recruitment of NuMA to mitotic centrosomes	5.36	2.15e-03	3.41e-02	5/55	TUBB2A; TUBB2B; TUBB; TUBA1A; DYNC1H1
R-HSA-8852276	The role of GTSE1 in G2/M progression after G2 checkpoint	5.36	2.15e-03	3.41e-02	5/55	TUBB2A; TUBB2B; PSMB7; TUBA1A; PSMB5
R-HSA-6791226	Major pathway of rRNA processing in the nucleolus and cytosol	4.98	1.06e-06	3.65e-05	13/154	RPL37A; RPL35A; RPL37; RPS10; RPS12; RPL39; RPL12; RPS24; RPL21; RPS2; RPL27; RPS19; RPS11
R-HSA-376176	Signaling by ROBO receptors	4.97	1.35e-07	5.29e-06	15/178	RPL37A; RPL35A; RPL37; RPS10; RPS12; RPL39; PSMB7; RPL12; RPS24; RPL21; PSMB5; RPS2; RPL27; RPS19; RPS11
R-HSA-8939236	RUNX1 regulates transcription of genes involved in differentiation of HSCs	4.92	3.16e-03	4.51e-02	5/60	H2AFZ; HIST1H4C; HIST1H2AC; PSMB7; PSMB5
R-HSA-8868773	rRNA processing in the nucleus and cytosol	4.79	1.65e-06	5.46e-05	13/160	RPL37A; RPL35A; RPL37; RPS10; RPS12; RPL39; RPL12; RPS24; RPL21; RPS2; RPL27; RPS19; RPS11
R-HSA-72312	rRNA processing	4.68	2.18e-06	6.97e-05	13/164	RPL37A; RPL35A; RPL37; RPS10; RPS12; RPL39; RPL12; RPS24; RPL21; RPS2; RPL27; RPS19; RPS11
R-HSA-72766	Translation	4.13	1.01e-07	4.36e-06	18/257	SARS; RPL37A; RPL35A; RPL37; RPS10; RPS12; RPL39; EIF4EBP1; RPL12; CARS; RPS24; RPL21; EIF5; RPS2; RPL27; EIF2S2; RPS19; RPS11
R-HSA-69275	G2/M Transition	3.87	9.01e-04	1.87e-02	8/122	TUBB2A; TUBB2B; TUBB; PSMB7; TUBA1A; PHLDA1; PSMB5; DYNC1H1
R-HSA-453274	Mitotic G2-G2/M phases	3.84	9.51e-04	1.90e-02	8/123	TUBB2A; TUBB2B; TUBB; PSMB7; TUBA1A; PHLDA1; PSMB5; DYNC1H1
R-HSA-422475	Axon guidance	3.42	8.37e-07	3.00e-05	19/328	RPL37A; RPL35A; RPL37; TUBB2A; TUBB2B; RPS10; RPS12; ACTB; RPL39; PSMB7; RPL12; RPS24; TUBA1A; RPL21; PSMB5; RPS2; RPL27; RPS19; RPS11
R-HSA-195258	RHO GTPase Effectors	3.28	2.63e-03	3.95e-02	8/144	H2AFZ; TUBB2A; TUBB2B; HIST1H4C; HIST1H2AC; ACTB; TUBA1A; DYNC1H1
R-HSA-5663205	Infectious disease	3.22	3.37e-05	9.08e-04	15/275	RPL37A; RPL35A; RPL37; RPS10; RPS12; RPL39; PSMB7; RPL12; RPS24; RPL21; PSMB5; RPS2; RPL27; RPS19; RPS11
R-HSA-1266738	Developmental Biology	3.05	2.97e-07	1.11e-05	23/445	NEUROD1; RPL37A; RPL35A; H2AFZ; RPL37; TUBB2A; TUBB2B; HIST1H4C; HIST1H2AC; RPS10; RPS12; ACTB; RPL39; PSMB7; RPL12; RPS24; TUBA1A; RPL21; PSMB5; RPS2; RPL27; RPS19; RPS11
R-HSA-68886	M Phase	2.89	1.93e-03	3.20e-02	10/204	H2AFZ; TUBB2A; TUBB2B; HIST1H4C; HIST1H2AC; TUBB; PSMB7; TUBA1A; PSMB5; DYNC1H1
R-HSA-69278	Cell Cycle, Mitotic	2.56	2.96e-03	4.31e-02	11/253	H2AFZ; TUBB2A; TUBB2B; HIST1H4C; HIST1H2AC; TUBB; PSMB7; TUBA1A; PHLDA1; PSMB5; DYNC1H1
R-HSA-1643685	Disease	2.16	1.27e-03	2.27e-02	17/464	PRDX1; RPL37A; RPL35A; RPL37; RPS10; RPS12; ACTB; RPL39; PSMB7; RPL12; RPS24; RPL21; PSMB5; RPS2; RPL27; RPS19; RPS11

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Factor 13 : 1 significant Reactome pathways

GeneSet	description	enrichRatio	pValue	FDR	GeneRatio	geneSymbols
R-HSA-5626467	RHO GTPases activate IQGAPs	42.1	3.89e-05	0.0335	3/18	CALM2; ACTB; ACTG1

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Factor 15 : 1 significant Reactome pathways

GeneSet	description	enrichRatio	pValue	FDR	GeneRatio	geneSymbols
R-HSA-397014	Muscle contraction	7.26	3.77e-05	0.0324	7/55	ATP2B4; CALM2; SCN9A; SRI; MYL6; MYL12A; FXYD7

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Factor 16 : 38 significant Reactome pathways

GeneSet	description	enrichRatio	pValue	FDR	GeneRatio	geneSymbols
R-HSA-442729	CREB phosphorylation through the activation of CaMKII	14.60	1.03e-04	0.0119	4/11	CALM2; NEFL; CALM1
R-HSA-442982	Ras activation upon Ca2+ influx through NMDA receptor	14.60	1.03e-04	0.0119	4/11	CALM2; NEFL; CALM1
R-HSA-8876725	Protein methylation	13.40	1.52e-04	0.0119	4/12	CALM2; CALM1; RPS2
R-HSA-5576892	Phase 0 - rapid depolarisation	13.40	1.52e-04	0.0119	4/12	CALM2; SCN9A; CALM1
R-HSA-2514856	The phototransduction cascade	12.10	1.57e-03	0.0423	3/10	CALM2; CALM1
R-HSA-2514859	Inactivation, recovery and regulation of the phototransduction cascade	12.10	1.57e-03	0.0423	3/10	CALM2; CALM1
R-HSA-5218921	VEGFR2 mediated cell proliferation	12.10	1.57e-03	0.0423	3/10	CALM2; CALM1
R-HSA-983695	Antigen activates B Cell Receptor (BCR) leading to generation of second messengers	12.10	1.57e-03	0.0423	3/10	CALM2; CALM1
R-HSA-70221	Glycogen breakdown (glycogenolysis)	12.10	1.57e-03	0.0423	3/10	CALM2; CALM1
R-HSA-2871809	FCERI mediated Ca+2 mobilization	11.00	2.12e-03	0.0499	3/11	CALM2; CALM1
R-HSA-111933	Calmodulin induced events	11.00	2.12e-03	0.0499	3/11	CALM2; CALM1
R-HSA-111997	CaM pathway	11.00	2.12e-03	0.0499	3/11	CALM2; CALM1
R-HSA-451326	Activation of kainate receptors upon glutamate binding	10.10	5.17e-04	0.0262	4/16	CALM2; GNG3; CALM1
R-HSA-442742	CREB phosphorylation through the activation of Ras	10.10	5.17e-04	0.0262	4/16	CALM2; NEFL; CALM1
R-HSA-5339562	Uptake and actions of bacterial toxins	9.46	6.63e-04	0.0301	4/17	CALM2; SYT1; CALM1
R-HSA-445355	Smooth Muscle Contraction	9.46	6.63e-04	0.0301	4/17	CALM2; CALD1; CALM1
R-HSA-70263	Gluconeogenesis	8.47	1.04e-03	0.0389	4/19	GAPDH; TPI1; ALDOA; ENO3
R-HSA-425393	Transport of inorganic cations/anions and amino acids/oligopeptides	8.47	1.04e-03	0.0389	4/19	CALM2; SLC17A6; CALM1
R-HSA-2672351	Stimuli-sensing channels	8.38	2.48e-04	0.0145	5/24	CALM2; ASIC4; ASIC1; CALM1
R-HSA-418346	Platelet homeostasis	8.04	7.32e-05	0.0119	6/30	CALM2; GNG3; ATP2B1; CALM1; PDE9A
R-HSA-438064	Post NMDA receptor activation events	8.04	1.28e-03	0.0422	4/20	CALM2; NEFL; CALM1
R-HSA-442755	Activation of NMDA receptors and postsynaptic events	7.66	1.55e-03	0.0423	4/21	CALM2; NEFL; CALM1
R-HSA-5578775	Ion homeostasis	6.99	2.20e-03	0.0499	4/23	CALM2; ATP2B1; CALM1
R-HSA-5576891	Cardiac conduction	6.89	1.81e-04	0.0120	6/35	CALM2; SCN9A; KCNIP2; ATP2B1; CALM1
R-HSA-2151201	Transcriptional activation of mitochondrial biogenesis	6.70	7.40e-04	0.0319	5/30	CALM2; MEF2C; ATP5B; CALM1
R-HSA-114608	Platelet degranulation	6.55	7.20e-05	0.0119	7/43	TAGLN2; CALM2; TMSB4X; SERPING1; CALM1; ALDOA
R-HSA-76005	Response to elevated platelet cytosolic Ca2+	6.55	7.20e-05	0.0119	7/43	TAGLN2; CALM2; TMSB4X; SERPING1; CALM1; ALDOA
R-HSA-8986944	Transcriptional Regulation by MECP2	6.49	8.65e-04	0.0355	5/31	CALM2; SST; MEF2C; CALM1
R-HSA-425407	SLC-mediated transmembrane transport	6.09	1.16e-03	0.0406	5/33	CALM2; SLC17A6; CALM1; SLCO3A1
R-HSA-397014	Muscle contraction	5.85	4.97e-05	0.0119	8/55	CALM2; SCN9A; MYL1; CALD1; KCNIP2; ATP2B1; CALM1
R-HSA-418594	G alpha (i) signalling events	4.95	1.68e-04	0.0120	8/65	RGS16; CALM2; SST; GNG3; GAL; RGS10; CALM1
R-HSA-112314	Neurotransmitter receptors and postsynaptic signal transmission	4.92	1.18e-03	0.0406	6/49	CALM2; CHRNA1; NEFL; GNG3; CALM1
R-HSA-76002	Platelet activation, signaling and aggregation	4.16	2.52e-04	0.0145	9/87	TAGLN2; CALM2; ABHD6; TMSB4X; SERPING1; GNG3; CALM1; ALDOA
R-HSA-388396	GPCR downstream signalling	3.81	1.11e-04	0.0119	11/116	RHOC; RGS16; CALM2; ABHD6; SST; GNG3; GAL; RGS10; CALM1; PTH2
R-HSA-372790	Signaling by GPCR	3.69	1.51e-04	0.0119	11/120	RHOC; RGS16; CALM2; ABHD6; SST; GNG3; GAL; RGS10; CALM1; PTH2
R-HSA-611105	Respiratory electron transport	3.39	2.20e-03	0.0499	8/95	COX7B; NDUFB9; COX8A; COX6A1; COX5A; NDUFB10; UQCR11; MT-CO3
R-HSA-163200	Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.	3.17	1.84e-03	0.0479	9/114	COX7B; NDUFB9; COX8A; ATP5B; COX6A1; COX5A; NDUFB10; UQCR11; MT-CO3
R-HSA-109582	Hemostasis	3.16	9.66e-05	0.0119	14/178	TAGLN2; CALM2; GYPC; ABHD6; CD47; TMSB4X; SERPING1; GNG3; ATP2B1; CALM1; ALDOA; H3F3B; PDE9A

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Factor 17 : 7 significant Reactome pathways

GeneSet	description	enrichRatio	pValue	FDR	GeneRatio	geneSymbols
R-HSA-5626467	RHO GTPases activate IQGAPs	15.90	1.01e-05	0.00868	5/18	CALM2; ACTB; TUBA1B; TUBA1A; ACTG1
R-HSA-190828	Gap junction trafficking	12.70	2.18e-04	0.04131	4/18	ACTB; TUBA1B; TUBA1A; ACTG1
R-HSA-157858	Gap junction trafficking and regulation	12.00	2.72e-04	0.04131	4/19	ACTB; TUBA1B; TUBA1A; ACTG1
R-HSA-1445148	Translocation of SLC2A4 (GLUT4) to the plasma membrane	7.61	1.08e-04	0.04131	6/45	CALM2; ACTB; TUBA1B; TUBA1A; YWHAE; ACTG1
R-HSA-2565942	Regulation of PLK1 Activity at G2/M Transition	6.23	3.36e-04	0.04131	6/55	SKP1; TUBB; DCTN3; TUBA1A; UBC; YWHAE
R-HSA-109582	Hemostasis	3.53	2.05e-04	0.04131	11/178	CAP1; GNG5; H3F3A; CALM2; HDAC2; ACTB; TMSB4X; MAGED2; TUBA1B; TUBA1A; CD63
R-HSA-69278	Cell Cycle, Mitotic	2.93	3.26e-04	0.04131	13/253	CKS1B; CENPF; H3F3A; SMC4; SKP1; PTTG1; HIST1H4C; TUBB; DCTN3; TUBA1B; TUBA1A; UBC; YWHAE

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Factor 18 : 33 significant Reactome pathways

GeneSet	description	enrichRatio	pValue	FDR	GeneRatio	geneSymbols
R-HSA-156902	Peptide chain elongation	33.60	0	0	79/84	RPL22; RPL11; RPS8; RPL5; RPS27; RPS7; RPS27A; RPL31; RPL37A; RPL32; RPL15; RPSA; RPL14; RPL29; RPL24; RPL35A; RPL9; RPL34; RPS3A; RPL37; RPS23; RPS14; RPS18; RPS10; RPL10A; EEF1A1; RPS12; RPS4X; RPL36A; RPL39; RPL10; RPS20; RPL7; RPL30; RPL8; RPS6; RPL35; RPL12; RPL7A; RPLP2; RPL27A; RPS13; RPS3; RPS25; RPS24; RPL41; RPL6; RPLP0; RPL21; RPS29; RPL4; RPLP1; RPS17; RPS2; RPS15A; RPL13; RPL26; RPL23A; RPL23; RPL19; RPL27; RPL38; RPL17; RPS21; RPS15; EEF2; RPL36; RPS28; RPL18A; UBA52; RPS16; RPS19; RPL18; RPL13A; RPS11; RPS9; RPL28; RPS5; RPL3
R-HSA-156842	Eukaryotic Translation Elongation	33.30	0	0	80/86	RPL22; RPL11; RPS8; RPL5; RPS27; RPS7; RPS27A; RPL31; EEF1B2; RPL37A; RPL32; RPL15; RPSA; RPL14; RPL29; RPL24; RPL35A; RPL9; RPL34; RPS3A; RPL37; RPS23; RPS14; RPS18; RPS10; RPL10A; EEF1A1; RPS12; RPS4X; RPL36A; RPL39; RPL10; RPS20; RPL7; RPL30; RPL8; RPS6; RPL35; RPL12; RPL7A; RPLP2; RPL27A; RPS13; RPS3; RPS25; RPS24; RPL41; RPL6; RPLP0; RPL21; RPS29; RPL4; RPLP1; RPS17; RPS2; RPS15A; RPL13; RPL26; RPL23A; RPL23; RPL19; RPL27; RPL38; RPL17; RPS21; RPS15; EEF2; RPL36; RPS28; RPL18A; UBA52; RPS16; RPS19; RPL18; RPL13A; RPS11; RPS9; RPL28; RPS5; RPL3
R-HSA-192823	Viral mRNA Translation	33.20	0	0	77/83	RPL22; RPL11; RPS8; RPL5; RPS27; RPS7; RPS27A; RPL31; RPL37A; RPL32; RPL15; RPSA; RPL14; RPL29; RPL24; RPL35A; RPL9; RPL34; RPS3A; RPL37; RPS23; RPS14; RPS18; RPS10; RPL10A; RPS12; RPS4X; RPL36A; RPL39; RPL10; RPS20; RPL7; RPL30; RPL8; RPS6; RPL35; RPL12; RPL7A; RPLP2; RPL27A; RPS13; RPS3; RPS25; RPS24; RPL41; RPL6; RPLP0; RPL21; RPS29; RPL4; RPLP1; RPS17; RPS2; RPS15A; RPL13; RPL26; RPL23A; RPL23; RPL19; RPL27; RPL38; RPL17; RPS21; RPS15; RPL36; RPS28; RPL18A; UBA52; RPS16; RPS19; RPL18; RPL13A; RPS11; RPS9; RPL28; RPS5; RPL3
R-HSA-2408557	Selenocysteine synthesis	32.40	0	0	77/85	RPL22; RPL11; RPS8; RPL5; RPS27; RPS7; RPS27A; RPL31; RPL37A; RPL32; RPL15; RPSA; RPL14; RPL29; RPL24; RPL35A; RPL9; RPL34; RPS3A; RPL37; RPS23; RPS14; RPS18; RPS10; RPL10A; RPS12; RPS4X; RPL36A; RPL39; RPL10; RPS20; RPL7; RPL30; RPL8; RPS6; RPL35; RPL12; RPL7A; RPLP2; RPL27A; RPS13; RPS3; RPS25; RPS24; RPL41; RPL6; RPLP0; RPL21; RPS29; RPL4; RPLP1; RPS17; RPS2; RPS15A; RPL13; RPL26; RPL23A; RPL23; RPL19; RPL27; RPL38; RPL17; RPS21; RPS15; RPL36; RPS28; RPL18A; UBA52; RPS16; RPS19; RPL18; RPL13A; RPS11; RPS9; RPL28; RPS5; RPL3
R-HSA-72764	Eukaryotic Translation Termination	32.00	0	0	77/86	RPL22; RPL11; RPS8; RPL5; RPS27; RPS7; RPS27A; RPL31; RPL37A; RPL32; RPL15; RPSA; RPL14; RPL29; RPL24; RPL35A; RPL9; RPL34; RPS3A; RPL37; RPS23; RPS14; RPS18; RPS10; RPL10A; RPS12; RPS4X; RPL36A; RPL39; RPL10; RPS20; RPL7; RPL30; RPL8; RPS6; RPL35; RPL12; RPL7A; RPLP2; RPL27A; RPS13; RPS3; RPS25; RPS24; RPL41; RPL6; RPLP0; RPL21; RPS29; RPL4; RPLP1; RPS17; RPS2; RPS15A; RPL13; RPL26; RPL23A; RPL23; RPL19; RPL27; RPL38; RPL17; RPS21; RPS15; RPL36; RPS28; RPL18A; UBA52; RPS16; RPS19; RPL18; RPL13A; RPS11; RPS9; RPL28; RPS5; RPL3
R-HSA-975956	Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)	31.30	0	0	77/88	RPL22; RPL11; RPS8; RPL5; RPS27; RPS7; RPS27A; RPL31; RPL37A; RPL32; RPL15; RPSA; RPL14; RPL29; RPL24; RPL35A; RPL9; RPL34; RPS3A; RPL37; RPS23; RPS14; RPS18; RPS10; RPL10A; RPS12; RPS4X; RPL36A; RPL39; RPL10; RPS20; RPL7; RPL30; RPL8; RPS6; RPL35; RPL12; RPL7A; RPLP2; RPL27A; RPS13; RPS3; RPS25; RPS24; RPL41; RPL6; RPLP0; RPL21; RPS29; RPL4; RPLP1; RPS17; RPS2; RPS15A; RPL13; RPL26; RPL23A; RPL23; RPL19; RPL27; RPL38; RPL17; RPS21; RPS15; RPL36; RPS28; RPL18A; UBA52; RPS16; RPS19; RPL18; RPL13A; RPS11; RPS9; RPL28; RPS5; RPL3
R-HSA-72689	Formation of a pool of free 40S subunits	29.00	0	0	77/95	RPL22; RPL11; RPS8; RPL5; RPS27; RPS7; RPS27A; RPL31; RPL37A; RPL32; RPL15; RPSA; RPL14; RPL29; RPL24; RPL35A; RPL9; RPL34; RPS3A; RPL37; RPS23; RPS14; RPS18; RPS10; RPL10A; RPS12; RPS4X; RPL36A; RPL39; RPL10; RPS20; RPL7; RPL30; RPL8; RPS6; RPL35; RPL12; RPL7A; RPLP2; RPL27A; RPS13; RPS3; RPS25; RPS24; RPL41; RPL6; RPLP0; RPL21; RPS29; RPL4; RPLP1; RPS17; RPS2; RPS15A; RPL13; RPL26; RPL23A; RPL23; RPL19; RPL27; RPL38; RPL17; RPS21; RPS15; RPL36; RPS28; RPL18A; UBA52; RPS16; RPS19; RPL18; RPL13A; RPS11; RPS9; RPL28; RPS5; RPL3
R-HSA-2408522	Selenoamino acid metabolism	27.80	0	0	77/99	RPL22; RPL11; RPS8; RPL5; RPS27; RPS7; RPS27A; RPL31; RPL37A; RPL32; RPL15; RPSA; RPL14; RPL29; RPL24; RPL35A; RPL9; RPL34; RPS3A; RPL37; RPS23; RPS14; RPS18; RPS10; RPL10A; RPS12; RPS4X; RPL36A; RPL39; RPL10; RPS20; RPL7; RPL30; RPL8; RPS6; RPL35; RPL12; RPL7A; RPLP2; RPL27A; RPS13; RPS3; RPS25; RPS24; RPL41; RPL6; RPLP0; RPL21; RPS29; RPL4; RPLP1; RPS17; RPS2; RPS15A; RPL13; RPL26; RPL23A; RPL23; RPL19; RPL27; RPL38; RPL17; RPS21; RPS15; RPL36; RPS28; RPL18A; UBA52; RPS16; RPS19; RPL18; RPL13A; RPS11; RPS9; RPL28; RPS5; RPL3
R-HSA-1799339	SRP-dependent cotranslational protein targeting to membrane	26.50	0	0	77/104	RPL22; RPL11; RPS8; RPL5; RPS27; RPS7; RPS27A; RPL31; RPL37A; RPL32; RPL15; RPSA; RPL14; RPL29; RPL24; RPL35A; RPL9; RPL34; RPS3A; RPL37; RPS23; RPS14; RPS18; RPS10; RPL10A; RPS12; RPS4X; RPL36A; RPL39; RPL10; RPS20; RPL7; RPL30; RPL8; RPS6; RPL35; RPL12; RPL7A; RPLP2; RPL27A; RPS13; RPS3; RPS25; RPS24; RPL41; RPL6; RPLP0; RPL21; RPS29; RPL4; RPLP1; RPS17; RPS2; RPS15A; RPL13; RPL26; RPL23A; RPL23; RPL19; RPL27; RPL38; RPL17; RPS21; RPS15; RPL36; RPS28; RPL18A; UBA52; RPS16; RPS19; RPL18; RPL13A; RPS11; RPS9; RPL28; RPS5; RPL3
R-HSA-156827	L13a-mediated translational silencing of Ceruloplasmin expression	26.20	0	0	77/105	RPL22; RPL11; RPS8; RPL5; RPS27; RPS7; RPS27A; RPL31; RPL37A; RPL32; RPL15; RPSA; RPL14; RPL29; RPL24; RPL35A; RPL9; RPL34; RPS3A; RPL37; RPS23; RPS14; RPS18; RPS10; RPL10A; RPS12; RPS4X; RPL36A; RPL39; RPL10; RPS20; RPL7; RPL30; RPL8; RPS6; RPL35; RPL12; RPL7A; RPLP2; RPL27A; RPS13; RPS3; RPS25; RPS24; RPL41; RPL6; RPLP0; RPL21; RPS29; RPL4; RPLP1; RPS17; RPS2; RPS15A; RPL13; RPL26; RPL23A; RPL23; RPL19; RPL27; RPL38; RPL17; RPS21; RPS15; RPL36; RPS28; RPL18A; UBA52; RPS16; RPS19; RPL18; RPL13A; RPS11; RPS9; RPL28; RPS5; RPL3
R-HSA-927802	Nonsense-Mediated Decay (NMD)	26.20	0	0	77/105	RPL22; RPL11; RPS8; RPL5; RPS27; RPS7; RPS27A; RPL31; RPL37A; RPL32; RPL15; RPSA; RPL14; RPL29; RPL24; RPL35A; RPL9; RPL34; RPS3A; RPL37; RPS23; RPS14; RPS18; RPS10; RPL10A; RPS12; RPS4X; RPL36A; RPL39; RPL10; RPS20; RPL7; RPL30; RPL8; RPS6; RPL35; RPL12; RPL7A; RPLP2; RPL27A; RPS13; RPS3; RPS25; RPS24; RPL41; RPL6; RPLP0; RPL21; RPS29; RPL4; RPLP1; RPS17; RPS2; RPS15A; RPL13; RPL26; RPL23A; RPL23; RPL19; RPL27; RPL38; RPL17; RPS21; RPS15; RPL36; RPS28; RPL18A; UBA52; RPS16; RPS19; RPL18; RPL13A; RPS11; RPS9; RPL28; RPS5; RPL3
R-HSA-975957	Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)	26.20	0	0	77/105	RPL22; RPL11; RPS8; RPL5; RPS27; RPS7; RPS27A; RPL31; RPL37A; RPL32; RPL15; RPSA; RPL14; RPL29; RPL24; RPL35A; RPL9; RPL34; RPS3A; RPL37; RPS23; RPS14; RPS18; RPS10; RPL10A; RPS12; RPS4X; RPL36A; RPL39; RPL10; RPS20; RPL7; RPL30; RPL8; RPS6; RPL35; RPL12; RPL7A; RPLP2; RPL27A; RPS13; RPS3; RPS25; RPS24; RPL41; RPL6; RPLP0; RPL21; RPS29; RPL4; RPLP1; RPS17; RPS2; RPS15A; RPL13; RPL26; RPL23A; RPL23; RPL19; RPL27; RPL38; RPL17; RPS21; RPS15; RPL36; RPS28; RPL18A; UBA52; RPS16; RPS19; RPL18; RPL13A; RPS11; RPS9; RPL28; RPS5; RPL3
R-HSA-72706	GTP hydrolysis and joining of the 60S ribosomal subunit	26.00	0	0	77/106	RPL22; RPL11; RPS8; RPL5; RPS27; RPS7; RPS27A; RPL31; RPL37A; RPL32; RPL15; RPSA; RPL14; RPL29; RPL24; RPL35A; RPL9; RPL34; RPS3A; RPL37; RPS23; RPS14; RPS18; RPS10; RPL10A; RPS12; RPS4X; RPL36A; RPL39; RPL10; RPS20; RPL7; RPL30; RPL8; RPS6; RPL35; RPL12; RPL7A; RPLP2; RPL27A; RPS13; RPS3; RPS25; RPS24; RPL41; RPL6; RPLP0; RPL21; RPS29; RPL4; RPLP1; RPS17; RPS2; RPS15A; RPL13; RPL26; RPL23A; RPL23; RPL19; RPL27; RPL38; RPL17; RPS21; RPS15; RPL36; RPS28; RPL18A; UBA52; RPS16; RPS19; RPL18; RPL13A; RPS11; RPS9; RPL28; RPS5; RPL3
R-HSA-72613	Eukaryotic Translation Initiation	24.40	0	0	77/113	RPL22; RPL11; RPS8; RPL5; RPS27; RPS7; RPS27A; RPL31; RPL37A; RPL32; RPL15; RPSA; RPL14; RPL29; RPL24; RPL35A; RPL9; RPL34; RPS3A; RPL37; RPS23; RPS14; RPS18; RPS10; RPL10A; RPS12; RPS4X; RPL36A; RPL39; RPL10; RPS20; RPL7; RPL30; RPL8; RPS6; RPL35; RPL12; RPL7A; RPLP2; RPL27A; RPS13; RPS3; RPS25; RPS24; RPL41; RPL6; RPLP0; RPL21; RPS29; RPL4; RPLP1; RPS17; RPS2; RPS15A; RPL13; RPL26; RPL23A; RPL23; RPL19; RPL27; RPL38; RPL17; RPS21; RPS15; RPL36; RPS28; RPL18A; UBA52; RPS16; RPS19; RPL18; RPL13A; RPS11; RPS9; RPL28; RPS5; RPL3
R-HSA-72737	Cap-dependent Translation Initiation	24.40	0	0	77/113	RPL22; RPL11; RPS8; RPL5; RPS27; RPS7; RPS27A; RPL31; RPL37A; RPL32; RPL15; RPSA; RPL14; RPL29; RPL24; RPL35A; RPL9; RPL34; RPS3A; RPL37; RPS23; RPS14; RPS18; RPS10; RPL10A; RPS12; RPS4X; RPL36A; RPL39; RPL10; RPS20; RPL7; RPL30; RPL8; RPS6; RPL35; RPL12; RPL7A; RPLP2; RPL27A; RPS13; RPS3; RPS25; RPS24; RPL41; RPL6; RPLP0; RPL21; RPS29; RPL4; RPLP1; RPS17; RPS2; RPS15A; RPL13; RPL26; RPL23A; RPL23; RPL19; RPL27; RPL38; RPL17; RPS21; RPS15; RPL36; RPS28; RPL18A; UBA52; RPS16; RPS19; RPL18; RPL13A; RPS11; RPS9; RPL28; RPS5; RPL3
R-HSA-168273	Influenza Viral RNA Transcription and Replication	24.40	0	0	77/113	RPL22; RPL11; RPS8; RPL5; RPS27; RPS7; RPS27A; RPL31; RPL37A; RPL32; RPL15; RPSA; RPL14; RPL29; RPL24; RPL35A; RPL9; RPL34; RPS3A; RPL37; RPS23; RPS14; RPS18; RPS10; RPL10A; RPS12; RPS4X; RPL36A; RPL39; RPL10; RPS20; RPL7; RPL30; RPL8; RPS6; RPL35; RPL12; RPL7A; RPLP2; RPL27A; RPS13; RPS3; RPS25; RPS24; RPL41; RPL6; RPLP0; RPL21; RPS29; RPL4; RPLP1; RPS17; RPS2; RPS15A; RPL13; RPL26; RPL23A; RPL23; RPL19; RPL27; RPL38; RPL17; RPS21; RPS15; RPL36; RPS28; RPL18A; UBA52; RPS16; RPS19; RPL18; RPL13A; RPS11; RPS9; RPL28; RPS5; RPL3
R-HSA-168255	Influenza Life Cycle	22.70	0	0	77/121	RPL22; RPL11; RPS8; RPL5; RPS27; RPS7; RPS27A; RPL31; RPL37A; RPL32; RPL15; RPSA; RPL14; RPL29; RPL24; RPL35A; RPL9; RPL34; RPS3A; RPL37; RPS23; RPS14; RPS18; RPS10; RPL10A; RPS12; RPS4X; RPL36A; RPL39; RPL10; RPS20; RPL7; RPL30; RPL8; RPS6; RPL35; RPL12; RPL7A; RPLP2; RPL27A; RPS13; RPS3; RPS25; RPS24; RPL41; RPL6; RPLP0; RPL21; RPS29; RPL4; RPLP1; RPS17; RPS2; RPS15A; RPL13; RPL26; RPL23A; RPL23; RPL19; RPL27; RPL38; RPL17; RPS21; RPS15; RPL36; RPS28; RPL18A; UBA52; RPS16; RPS19; RPL18; RPL13A; RPS11; RPS9; RPL28; RPS5; RPL3
R-HSA-72695	Formation of the ternary complex, and subsequently, the 43S complex	22.30	0	0	30/48	RPS8; RPS27; RPS7; RPS27A; RPSA; RPS3A; RPS23; RPS14; RPS18; RPS10; RPS12; RPS4X; RPS20; RPS6; RPS13; RPS3; RPS25; RPS24; RPS29; RPS17; RPS2; RPS15A; RPS21; RPS15; RPS28; RPS16; RPS19; RPS11; RPS9; RPS5
R-HSA-168254	Influenza Infection	21.80	0	0	78/128	RPL22; RPL11; RPS8; RPL5; RPS27; RPS7; RPS27A; RPL31; RPL37A; RPL32; RPL15; RPSA; RPL14; RPL29; RPL24; RPL35A; RPL9; RPL34; RPS3A; RPL37; RPS23; RPS14; RPS18; RPS10; RPL10A; RPS12; SLC25A6; RPS4X; RPL36A; RPL39; RPL10; RPS20; RPL7; RPL30; RPL8; RPS6; RPL35; RPL12; RPL7A; RPLP2; RPL27A; RPS13; RPS3; RPS25; RPS24; RPL41; RPL6; RPLP0; RPL21; RPS29; RPL4; RPLP1; RPS17; RPS2; RPS15A; RPL13; RPL26; RPL23A; RPL23; RPL19; RPL27; RPL38; RPL17; RPS21; RPS15; RPL36; RPS28; RPL18A; UBA52; RPS16; RPS19; RPL18; RPL13A; RPS11; RPS9; RPL28; RPS5; RPL3
R-HSA-72649	Translation initiation complex formation	19.50	0	0	30/55	RPS8; RPS27; RPS7; RPS27A; RPSA; RPS3A; RPS23; RPS14; RPS18; RPS10; RPS12; RPS4X; RPS20; RPS6; RPS13; RPS3; RPS25; RPS24; RPS29; RPS17; RPS2; RPS15A; RPS21; RPS15; RPS28; RPS16; RPS19; RPS11; RPS9; RPS5
R-HSA-72702	Ribosomal scanning and start codon recognition	19.50	0	0	30/55	RPS8; RPS27; RPS7; RPS27A; RPSA; RPS3A; RPS23; RPS14; RPS18; RPS10; RPS12; RPS4X; RPS20; RPS6; RPS13; RPS3; RPS25; RPS24; RPS29; RPS17; RPS2; RPS15A; RPS21; RPS15; RPS28; RPS16; RPS19; RPS11; RPS9; RPS5
R-HSA-72662	Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S	19.20	0	0	30/56	RPS8; RPS27; RPS7; RPS27A; RPSA; RPS3A; RPS23; RPS14; RPS18; RPS10; RPS12; RPS4X; RPS20; RPS6; RPS13; RPS3; RPS25; RPS24; RPS29; RPS17; RPS2; RPS15A; RPS21; RPS15; RPS28; RPS16; RPS19; RPS11; RPS9; RPS5
R-HSA-9010553	Regulation of expression of SLITs and ROBOs	18.50	0	0	77/149	RPL22; RPL11; RPS8; RPL5; RPS27; RPS7; RPS27A; RPL31; RPL37A; RPL32; RPL15; RPSA; RPL14; RPL29; RPL24; RPL35A; RPL9; RPL34; RPS3A; RPL37; RPS23; RPS14; RPS18; RPS10; RPL10A; RPS12; RPS4X; RPL36A; RPL39; RPL10; RPS20; RPL7; RPL30; RPL8; RPS6; RPL35; RPL12; RPL7A; RPLP2; RPL27A; RPS13; RPS3; RPS25; RPS24; RPL41; RPL6; RPLP0; RPL21; RPS29; RPL4; RPLP1; RPS17; RPS2; RPS15A; RPL13; RPL26; RPL23A; RPL23; RPL19; RPL27; RPL38; RPL17; RPS21; RPS15; RPL36; RPS28; RPL18A; UBA52; RPS16; RPS19; RPL18; RPL13A; RPS11; RPS9; RPL28; RPS5; RPL3
R-HSA-6791226	Major pathway of rRNA processing in the nucleolus and cytosol	17.90	0	0	77/154	RPL22; RPL11; RPS8; RPL5; RPS27; RPS7; RPS27A; RPL31; RPL37A; RPL32; RPL15; RPSA; RPL14; RPL29; RPL24; RPL35A; RPL9; RPL34; RPS3A; RPL37; RPS23; RPS14; RPS18; RPS10; RPL10A; RPS12; RPS4X; RPL36A; RPL39; RPL10; RPS20; RPL7; RPL30; RPL8; RPS6; RPL35; RPL12; RPL7A; RPLP2; RPL27A; RPS13; RPS3; RPS25; RPS24; RPL41; RPL6; RPLP0; RPL21; RPS29; RPL4; RPLP1; RPS17; RPS2; RPS15A; RPL13; RPL26; RPL23A; RPL23; RPL19; RPL27; RPL38; RPL17; RPS21; RPS15; RPL36; RPS28; RPL18A; UBA52; RPS16; RPS19; RPL18; RPL13A; RPS11; RPS9; RPL28; RPS5; RPL3
R-HSA-8868773	rRNA processing in the nucleus and cytosol	17.20	0	0	77/160	RPL22; RPL11; RPS8; RPL5; RPS27; RPS7; RPS27A; RPL31; RPL37A; RPL32; RPL15; RPSA; RPL14; RPL29; RPL24; RPL35A; RPL9; RPL34; RPS3A; RPL37; RPS23; RPS14; RPS18; RPS10; RPL10A; RPS12; RPS4X; RPL36A; RPL39; RPL10; RPS20; RPL7; RPL30; RPL8; RPS6; RPL35; RPL12; RPL7A; RPLP2; RPL27A; RPS13; RPS3; RPS25; RPS24; RPL41; RPL6; RPLP0; RPL21; RPS29; RPL4; RPLP1; RPS17; RPS2; RPS15A; RPL13; RPL26; RPL23A; RPL23; RPL19; RPL27; RPL38; RPL17; RPS21; RPS15; RPL36; RPS28; RPL18A; UBA52; RPS16; RPS19; RPL18; RPL13A; RPS11; RPS9; RPL28; RPS5; RPL3
R-HSA-72312	rRNA processing	16.80	0	0	77/164	RPL22; RPL11; RPS8; RPL5; RPS27; RPS7; RPS27A; RPL31; RPL37A; RPL32; RPL15; RPSA; RPL14; RPL29; RPL24; RPL35A; RPL9; RPL34; RPS3A; RPL37; RPS23; RPS14; RPS18; RPS10; RPL10A; RPS12; RPS4X; RPL36A; RPL39; RPL10; RPS20; RPL7; RPL30; RPL8; RPS6; RPL35; RPL12; RPL7A; RPLP2; RPL27A; RPS13; RPS3; RPS25; RPS24; RPL41; RPL6; RPLP0; RPL21; RPS29; RPL4; RPLP1; RPS17; RPS2; RPS15A; RPL13; RPL26; RPL23A; RPL23; RPL19; RPL27; RPL38; RPL17; RPS21; RPS15; RPL36; RPS28; RPL18A; UBA52; RPS16; RPS19; RPL18; RPL13A; RPS11; RPS9; RPL28; RPS5; RPL3
R-HSA-376176	Signaling by ROBO receptors	15.50	0	0	77/178	RPL22; RPL11; RPS8; RPL5; RPS27; RPS7; RPS27A; RPL31; RPL37A; RPL32; RPL15; RPSA; RPL14; RPL29; RPL24; RPL35A; RPL9; RPL34; RPS3A; RPL37; RPS23; RPS14; RPS18; RPS10; RPL10A; RPS12; RPS4X; RPL36A; RPL39; RPL10; RPS20; RPL7; RPL30; RPL8; RPS6; RPL35; RPL12; RPL7A; RPLP2; RPL27A; RPS13; RPS3; RPS25; RPS24; RPL41; RPL6; RPLP0; RPL21; RPS29; RPL4; RPLP1; RPS17; RPS2; RPS15A; RPL13; RPL26; RPL23A; RPL23; RPL19; RPL27; RPL38; RPL17; RPS21; RPS15; RPL36; RPS28; RPL18A; UBA52; RPS16; RPS19; RPL18; RPL13A; RPS11; RPS9; RPL28; RPS5; RPL3
R-HSA-71291	Metabolism of amino acids and derivatives	13.20	0	0	77/209	RPL22; RPL11; RPS8; RPL5; RPS27; RPS7; RPS27A; RPL31; RPL37A; RPL32; RPL15; RPSA; RPL14; RPL29; RPL24; RPL35A; RPL9; RPL34; RPS3A; RPL37; RPS23; RPS14; RPS18; RPS10; RPL10A; RPS12; RPS4X; RPL36A; RPL39; RPL10; RPS20; RPL7; RPL30; RPL8; RPS6; RPL35; RPL12; RPL7A; RPLP2; RPL27A; RPS13; RPS3; RPS25; RPS24; RPL41; RPL6; RPLP0; RPL21; RPS29; RPL4; RPLP1; RPS17; RPS2; RPS15A; RPL13; RPL26; RPL23A; RPL23; RPL19; RPL27; RPL38; RPL17; RPS21; RPS15; RPL36; RPS28; RPL18A; UBA52; RPS16; RPS19; RPL18; RPL13A; RPS11; RPS9; RPL28; RPS5; RPL3
R-HSA-72766	Translation	11.10	0	0	80/257	RPL22; RPL11; RPS8; RPL5; RPS27; RPS7; RPS27A; RPL31; EEF1B2; RPL37A; RPL32; RPL15; RPSA; RPL14; RPL29; RPL24; RPL35A; RPL9; RPL34; RPS3A; RPL37; RPS23; RPS14; RPS18; RPS10; RPL10A; EEF1A1; RPS12; RPS4X; RPL36A; RPL39; RPL10; RPS20; RPL7; RPL30; RPL8; RPS6; RPL35; RPL12; RPL7A; RPLP2; RPL27A; RPS13; RPS3; RPS25; RPS24; RPL41; RPL6; RPLP0; RPL21; RPS29; RPL4; RPLP1; RPS17; RPS2; RPS15A; RPL13; RPL26; RPL23A; RPL23; RPL19; RPL27; RPL38; RPL17; RPS21; RPS15; EEF2; RPL36; RPS28; RPL18A; UBA52; RPS16; RPS19; RPL18; RPL13A; RPS11; RPS9; RPL28; RPS5; RPL3
R-HSA-5663205	Infectious disease	10.30	0	0	79/275	RPL22; RPL11; RPS8; RPL5; RPS27; RPS7; RPS27A; RPL31; RPL37A; RPL32; RPL15; RPSA; RPL14; RPL29; RPL24; RPL35A; RPL9; RPL34; RPS3A; RPL37; RPS23; RPS14; RPS18; RPS10; RPL10A; RPS12; SLC25A6; RPS4X; RPL36A; RPL39; RPL10; RPS20; RPL7; RPL30; RPL8; RPS6; RPL35; RPL12; RPL7A; RPLP2; RPL27A; RPS13; RPS3; RPS25; RPS24; RPL41; RPL6; RPLP0; RPL21; RPS29; RPL4; RPLP1; RPS17; RPS2; RPS15A; RPL13; RPL26; RPL23A; RPL23; RPL19; RPL27; RPL38; RPL17; RPS21; RPS15; EEF2; RPL36; RPS28; RPL18A; UBA52; RPS16; RPS19; RPL18; RPL13A; RPS11; RPS9; RPL28; RPS5; RPL3
R-HSA-422475	Axon guidance	8.50	0	0	78/328	RPL22; RPL11; RPS8; RPL5; RPS27; RPS7; RPS27A; RPL31; RPL37A; RPL32; RPL15; RPSA; RPL14; RPL29; RPL24; RPL35A; RPL9; RPL34; RPS3A; RPL37; RPS23; RPS14; RPS18; RPS10; RPL10A; RPS12; RPS4X; RPL36A; RPL39; RPL10; RPS20; RPL7; RPL30; RPL8; RPS6; RPL35; RPL12; RPL7A; RPLP2; RPL27A; RPS13; RPS3; RPS25; RPS24; RPL41; MYL6; RPL6; RPLP0; RPL21; RPS29; RPL4; RPLP1; RPS17; RPS2; RPS15A; RPL13; RPL26; RPL23A; RPL23; RPL19; RPL27; RPL38; RPL17; RPS21; RPS15; RPL36; RPS28; RPL18A; UBA52; RPS16; RPS19; RPL18; RPL13A; RPS11; RPS9; RPL28; RPS5; RPL3
R-HSA-1266738	Developmental Biology	6.27	0	0	78/445	RPL22; RPL11; RPS8; RPL5; RPS27; RPS7; RPS27A; RPL31; RPL37A; RPL32; RPL15; RPSA; RPL14; RPL29; RPL24; RPL35A; RPL9; RPL34; RPS3A; RPL37; RPS23; RPS14; RPS18; RPS10; RPL10A; RPS12; RPS4X; RPL36A; RPL39; RPL10; RPS20; RPL7; RPL30; RPL8; RPS6; RPL35; RPL12; RPL7A; RPLP2; RPL27A; RPS13; RPS3; RPS25; RPS24; RPL41; MYL6; RPL6; RPLP0; RPL21; RPS29; RPL4; RPLP1; RPS17; RPS2; RPS15A; RPL13; RPL26; RPL23A; RPL23; RPL19; RPL27; RPL38; RPL17; RPS21; RPS15; RPL36; RPS28; RPL18A; UBA52; RPS16; RPS19; RPL18; RPL13A; RPS11; RPS9; RPL28; RPS5; RPL3
R-HSA-1643685	Disease	6.09	0	0	79/464	RPL22; RPL11; RPS8; RPL5; RPS27; RPS7; RPS27A; RPL31; RPL37A; RPL32; RPL15; RPSA; RPL14; RPL29; RPL24; RPL35A; RPL9; RPL34; RPS3A; RPL37; RPS23; RPS14; RPS18; RPS10; RPL10A; RPS12; SLC25A6; RPS4X; RPL36A; RPL39; RPL10; RPS20; RPL7; RPL30; RPL8; RPS6; RPL35; RPL12; RPL7A; RPLP2; RPL27A; RPS13; RPS3; RPS25; RPS24; RPL41; RPL6; RPLP0; RPL21; RPS29; RPL4; RPLP1; RPS17; RPS2; RPS15A; RPL13; RPL26; RPL23A; RPL23; RPL19; RPL27; RPL38; RPL17; RPS21; RPS15; EEF2; RPL36; RPS28; RPL18A; UBA52; RPS16; RPS19; RPL18; RPL13A; RPS11; RPS9; RPL28; RPS5; RPL3

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Factor 19 : 37 significant Reactome pathways

GeneSet	description	enrichRatio	pValue	FDR	GeneRatio	geneSymbols
R-HSA-72689	Formation of a pool of free 40S subunits	15.10	0.00e+00	0.00e+00	32/95	RPL5; RPS7; RPL37A; RPL15; RPSA; RPL14; RPS3A; RPL10A; RPS4X; RPL10; RPS20; RPL7; EIF3E; EIF3H; RPL35; RPL7A; EIF3F; EIF3M; RPS3; RPL41; RPL6; RPS29; RPL4; RPS2; RPL23; RPL36; RPS28; RPL13A; RPS9; EIF3D; EIF3L; RPL3
R-HSA-156902	Peptide chain elongation	14.90	0.00e+00	0.00e+00	28/84	RPL5; RPS7; RPL37A; RPL15; RPSA; RPL14; RPS3A; RPL10A; EEF1A1; RPS4X; RPL10; RPS20; RPL7; RPL35; RPL7A; RPS3; RPL41; RPL6; RPS29; RPL4; RPS2; RPL23; EEF2; RPL36; RPS28; RPL13A; RPS9; RPL3
R-HSA-72695	Formation of the ternary complex, and subsequently, the 43S complex	14.90	9.99e-16	2.97e-14	16/48	RPS7; RPSA; RPS3A; RPS4X; RPS20; EIF3E; EIF3H; EIF3F; EIF3M; RPS3; RPS29; RPS2; RPS28; RPS9; EIF3D; EIF3L
R-HSA-156842	Eukaryotic Translation Elongation	14.60	0.00e+00	0.00e+00	28/86	RPL5; RPS7; RPL37A; RPL15; RPSA; RPL14; RPS3A; RPL10A; EEF1A1; RPS4X; RPL10; RPS20; RPL7; RPL35; RPL7A; RPS3; RPL41; RPL6; RPS29; RPL4; RPS2; RPL23; EEF2; RPL36; RPS28; RPL13A; RPS9; RPL3
R-HSA-156827	L13a-mediated translational silencing of Ceruloplasmin expression	14.10	0.00e+00	0.00e+00	33/105	RPL5; RPS7; RPL37A; RPL15; RPSA; RPL14; EIF4A2; RPS3A; RPL10A; RPS4X; RPL10; RPS20; RPL7; EIF3E; EIF3H; RPL35; RPL7A; EIF3F; EIF3M; RPS3; RPL41; RPL6; RPS29; RPL4; RPS2; RPL23; RPL36; RPS28; RPL13A; RPS9; EIF3D; EIF3L; RPL3
R-HSA-192823	Viral mRNA Translation	14.00	0.00e+00	0.00e+00	26/83	RPL5; RPS7; RPL37A; RPL15; RPSA; RPL14; RPS3A; RPL10A; RPS4X; RPL10; RPS20; RPL7; RPL35; RPL7A; RPS3; RPL41; RPL6; RPS29; RPL4; RPS2; RPL23; RPL36; RPS28; RPL13A; RPS9; RPL3
R-HSA-72706	GTP hydrolysis and joining of the 60S ribosomal subunit	13.90	0.00e+00	0.00e+00	33/106	RPL5; RPS7; RPL37A; RPL15; RPSA; RPL14; EIF4A2; RPS3A; RPL10A; RPS4X; RPL10; RPS20; RPL7; EIF3E; EIF3H; RPL35; RPL7A; EIF3F; EIF3M; RPS3; RPL41; RPL6; RPS29; RPL4; RPS2; RPL23; RPL36; RPS28; RPL13A; RPS9; EIF3D; EIF3L; RPL3
R-HSA-72649	Translation initiation complex formation	13.80	4.44e-16	1.47e-14	17/55	RPS7; RPSA; EIF4A2; RPS3A; RPS4X; RPS20; EIF3E; EIF3H; EIF3F; EIF3M; RPS3; RPS29; RPS2; RPS28; RPS9; EIF3D; EIF3L
R-HSA-72702	Ribosomal scanning and start codon recognition	13.80	4.44e-16	1.47e-14	17/55	RPS7; RPSA; EIF4A2; RPS3A; RPS4X; RPS20; EIF3E; EIF3H; EIF3F; EIF3M; RPS3; RPS29; RPS2; RPS28; RPS9; EIF3D; EIF3L
R-HSA-2408557	Selenocysteine synthesis	13.70	0.00e+00	0.00e+00	26/85	RPL5; RPS7; RPL37A; RPL15; RPSA; RPL14; RPS3A; RPL10A; RPS4X; RPL10; RPS20; RPL7; RPL35; RPL7A; RPS3; RPL41; RPL6; RPS29; RPL4; RPS2; RPL23; RPL36; RPS28; RPL13A; RPS9; RPL3
R-HSA-72662	Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S	13.60	6.66e-16	2.12e-14	17/56	RPS7; RPSA; EIF4A2; RPS3A; RPS4X; RPS20; EIF3E; EIF3H; EIF3F; EIF3M; RPS3; RPS29; RPS2; RPS28; RPS9; EIF3D; EIF3L
R-HSA-72764	Eukaryotic Translation Termination	13.50	0.00e+00	0.00e+00	26/86	RPL5; RPS7; RPL37A; RPL15; RPSA; RPL14; RPS3A; RPL10A; RPS4X; RPL10; RPS20; RPL7; RPL35; RPL7A; RPS3; RPL41; RPL6; RPS29; RPL4; RPS2; RPL23; RPL36; RPS28; RPL13A; RPS9; RPL3
R-HSA-975956	Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)	13.20	0.00e+00	0.00e+00	26/88	RPL5; RPS7; RPL37A; RPL15; RPSA; RPL14; RPS3A; RPL10A; RPS4X; RPL10; RPS20; RPL7; RPL35; RPL7A; RPS3; RPL41; RPL6; RPS29; RPL4; RPS2; RPL23; RPL36; RPS28; RPL13A; RPS9; RPL3
R-HSA-72613	Eukaryotic Translation Initiation	13.10	0.00e+00	0.00e+00	33/113	RPL5; RPS7; RPL37A; RPL15; RPSA; RPL14; EIF4A2; RPS3A; RPL10A; RPS4X; RPL10; RPS20; RPL7; EIF3E; EIF3H; RPL35; RPL7A; EIF3F; EIF3M; RPS3; RPL41; RPL6; RPS29; RPL4; RPS2; RPL23; RPL36; RPS28; RPL13A; RPS9; EIF3D; EIF3L; RPL3
R-HSA-72737	Cap-dependent Translation Initiation	13.10	0.00e+00	0.00e+00	33/113	RPL5; RPS7; RPL37A; RPL15; RPSA; RPL14; EIF4A2; RPS3A; RPL10A; RPS4X; RPL10; RPS20; RPL7; EIF3E; EIF3H; RPL35; RPL7A; EIF3F; EIF3M; RPS3; RPL41; RPL6; RPS29; RPL4; RPS2; RPL23; RPL36; RPS28; RPL13A; RPS9; EIF3D; EIF3L; RPL3
R-HSA-2408522	Selenoamino acid metabolism	12.20	0.00e+00	0.00e+00	27/99	RPL5; RPS7; RPL37A; RPL15; RPSA; RPL14; QARS; RPS3A; RPL10A; RPS4X; RPL10; RPS20; RPL7; RPL35; RPL7A; RPS3; RPL41; RPL6; RPS29; RPL4; RPS2; RPL23; RPL36; RPS28; RPL13A; RPS9; RPL3
R-HSA-1799339	SRP-dependent cotranslational protein targeting to membrane	11.60	0.00e+00	0.00e+00	27/104	RPL5; SRP9; RPS7; RPL37A; RPL15; RPSA; RPL14; RPS3A; RPL10A; RPS4X; RPL10; RPS20; RPL7; RPL35; RPL7A; RPS3; RPL41; RPL6; RPS29; RPL4; RPS2; RPL23; RPL36; RPS28; RPL13A; RPS9; RPL3
R-HSA-8876725	Protein methylation	11.20	2.04e-03	4.74e-02	3/12	EEF1A1; RPS2; EEF2
R-HSA-927802	Nonsense-Mediated Decay (NMD)	11.10	0.00e+00	0.00e+00	26/105	RPL5; RPS7; RPL37A; RPL15; RPSA; RPL14; RPS3A; RPL10A; RPS4X; RPL10; RPS20; RPL7; RPL35; RPL7A; RPS3; RPL41; RPL6; RPS29; RPL4; RPS2; RPL23; RPL36; RPS28; RPL13A; RPS9; RPL3
R-HSA-975957	Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)	11.10	0.00e+00	0.00e+00	26/105	RPL5; RPS7; RPL37A; RPL15; RPSA; RPL14; RPS3A; RPL10A; RPS4X; RPL10; RPS20; RPL7; RPL35; RPL7A; RPS3; RPL41; RPL6; RPS29; RPL4; RPS2; RPL23; RPL36; RPS28; RPL13A; RPS9; RPL3
R-HSA-168273	Influenza Viral RNA Transcription and Replication	10.70	0.00e+00	0.00e+00	27/113	RPL5; RPS7; RPL37A; RPL15; RPSA; RPL14; RPS3A; RPL10A; RPS4X; RPL10; RPS20; RPL7; RPL35; RPL7A; RPS3; RPL41; RPL6; RPS29; HSP90AA1; RPL4; RPS2; RPL23; RPL36; RPS28; RPL13A; RPS9; RPL3
R-HSA-191273	Cholesterol biosynthesis	10.70	7.51e-05	1.90e-03	5/21	FDPS; ACAT2; EBP; SQLE; DHCR7
R-HSA-168255	Influenza Life Cycle	10.00	0.00e+00	0.00e+00	27/121	RPL5; RPS7; RPL37A; RPL15; RPSA; RPL14; RPS3A; RPL10A; RPS4X; RPL10; RPS20; RPL7; RPL35; RPL7A; RPS3; RPL41; RPL6; RPS29; HSP90AA1; RPL4; RPS2; RPL23; RPL36; RPS28; RPL13A; RPS9; RPL3
R-HSA-168254	Influenza Infection	9.80	0.00e+00	0.00e+00	28/128	RPL5; RPS7; RPL37A; RPL15; RPSA; RPL14; RPS3A; RPL10A; SLC25A6; RPS4X; RPL10; RPS20; RPL7; RPL35; RPL7A; RPS3; RPL41; RPL6; RPS29; HSP90AA1; RPL4; RPS2; RPL23; RPL36; RPS28; RPL13A; RPS9; RPL3
R-HSA-9010553	Regulation of expression of SLITs and ROBOs	7.82	0.00e+00	0.00e+00	26/149	RPL5; RPS7; RPL37A; RPL15; RPSA; RPL14; RPS3A; RPL10A; RPS4X; RPL10; RPS20; RPL7; RPL35; RPL7A; RPS3; RPL41; RPL6; RPS29; RPL4; RPS2; RPL23; RPL36; RPS28; RPL13A; RPS9; RPL3
R-HSA-6791226	Major pathway of rRNA processing in the nucleolus and cytosol	7.56	0.00e+00	0.00e+00	26/154	RPL5; RPS7; RPL37A; RPL15; RPSA; RPL14; RPS3A; RPL10A; RPS4X; RPL10; RPS20; RPL7; RPL35; RPL7A; RPS3; RPL41; RPL6; RPS29; RPL4; RPS2; RPL23; RPL36; RPS28; RPL13A; RPS9; RPL3
R-HSA-8868773	rRNA processing in the nucleus and cytosol	7.28	1.11e-16	4.16e-15	26/160	RPL5; RPS7; RPL37A; RPL15; RPSA; RPL14; RPS3A; RPL10A; RPS4X; RPL10; RPS20; RPL7; RPL35; RPL7A; RPS3; RPL41; RPL6; RPS29; RPL4; RPS2; RPL23; RPL36; RPS28; RPL13A; RPS9; RPL3
R-HSA-72312	rRNA processing	7.10	2.22e-16	7.97e-15	26/164	RPL5; RPS7; RPL37A; RPL15; RPSA; RPL14; RPS3A; RPL10A; RPS4X; RPL10; RPS20; RPL7; RPL35; RPL7A; RPS3; RPL41; RPL6; RPS29; RPL4; RPS2; RPL23; RPL36; RPS28; RPL13A; RPS9; RPL3
R-HSA-376176	Signaling by ROBO receptors	6.54	1.55e-15	4.46e-14	26/178	RPL5; RPS7; RPL37A; RPL15; RPSA; RPL14; RPS3A; RPL10A; RPS4X; RPL10; RPS20; RPL7; RPL35; RPL7A; RPS3; RPL41; RPL6; RPS29; RPL4; RPS2; RPL23; RPL36; RPS28; RPL13A; RPS9; RPL3
R-HSA-72766	Translation	6.45	0.00e+00	0.00e+00	37/257	RPL5; SRP9; RPS7; RPL37A; RPL15; RPSA; RPL14; QARS; EIF4A2; RPS3A; RPL10A; EEF1A1; RPS4X; RPL10; RPS20; RPL7; EIF3E; EIF3H; RPL35; RPL7A; EIF3F; EIF3M; RPS3; RPL41; RPL6; RPS29; RPL4; RPS2; RPL23; EEF2; RPL36; RPS28; RPL13A; RPS9; EIF3D; EIF3L; RPL3
R-HSA-2029482	Regulation of actin dynamics for phagocytic cup formation	6.05	1.22e-03	2.96e-02	5/37	ARPC5; ACTB; CFL1; HSP90AA1; ACTG1
R-HSA-71291	Metabolism of amino acids and derivatives	6.00	8.88e-16	2.73e-14	28/209	RPL5; RPS7; RPL37A; RPL15; RPSA; RPL14; QARS; RPS3A; RPL10A; RPS4X; RPL10; RPS20; RPL7; RPL35; RPL7A; RPS3; RPL41; RPL6; RPS29; CKB; RPL4; RPS2; RPL23; RPL36; RPS28; RPL13A; RPS9; RPL3
R-HSA-5663205	Infectious disease	5.05	2.44e-15	6.78e-14	31/275	RPL5; RPS7; RPL37A; RPL15; RPSA; RPL14; RPS3A; NPM1; HMGA1; RPL10A; SLC25A6; RPS4X; RPL10; RPS20; RPL7; RPL35; RPL7A; RPS3; RPL41; RPL6; RPS29; HSP90AA1; RPL4; RPS2; RPL23; EEF2; RPL36; RPS28; RPL13A; RPS9; RPL3
R-HSA-2682334	EPH-Ephrin signaling	4.89	1.24e-03	2.96e-02	6/55	ARPC5; ACTB; CFL1; MYL6; ACTG1; MYL12A
R-HSA-422475	Axon guidance	4.78	1.11e-16	4.16e-15	35/328	RPL5; ARPC5; RPS7; RPL37A; RPL15; RPSA; RPL14; RPS3A; PDLIM7; RPL10A; ACTB; RPS4X; RPL10; RPS20; RPL7; RPL35; RPL7A; CFL1; RPS3; TUBA1A; RPL41; MYL6; RPL6; RPS29; HSP90AA1; RPL4; RPS2; RPL23; ACTG1; MYL12A; RPL36; RPS28; RPL13A; RPS9; RPL3
R-HSA-1266738	Developmental Biology	3.72	3.59e-14	9.65e-13	37/445	RPL5; ARPC5; H3F3A; RPS7; RPL37A; RPL15; RPSA; RPL14; RPS3A; PDLIM7; RPL10A; ACTB; RPS4X; RPL10; RPS20; RPL7; RPL35; RPL7A; CFL1; RPS3; TUBA1A; RPL41; MYL6; RPL6; RPS29; HSP90AA1; RPL4; RPS2; RPL23; H3F3B; ACTG1; MYL12A; RPL36; RPS28; RPL13A; RPS9; RPL3
R-HSA-1643685	Disease	3.28	2.79e-11	7.27e-10	34/464	RPL5; RPS7; RPL37A; RPL15; RPSA; RPL14; RPS3A; NPM1; HMGA1; RPL10A; ACTB; SLC25A6; RPS4X; RPL10; RPS20; RPL7; RPL35; RPL7A; RPS3; RPL41; RPL6; RPS29; HSP90AA1; RPL4; RPS2; RPL23; ACTG1; FKBP1A; EEF2; RPL36; RPS28; RPL13A; RPS9; RPL3

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Factor 20 : 14 significant Reactome pathways

GeneSet	description	enrichRatio	pValue	FDR	GeneRatio	geneSymbols
R-HSA-5576892	Phase 0 - rapid depolarisation	15.90	7.68e-05	0.006616	4/12	SCN9A; CAMK2B; CALM1
R-HSA-5578775	Ion homeostasis	12.50	5.19e-06	0.001253	6/23	ATP2B4; RYR2; CAMK2B; FXYD6; CALM1
R-HSA-500792	GPCR ligand binding	12.40	8.34e-07	0.000718	7/27	GNG5; SST; GABBR2; GNG3; GAL; SSTR2; PTH2
R-HSA-451326	Activation of kainate receptors upon glutamate binding	12.00	2.65e-04	0.019021	4/16	GNG5; GNG3; CALM1
R-HSA-5626467	RHO GTPases activate IQGAPs	10.60	4.32e-04	0.028598	4/18	ACTB; TUBA1A; CALM1
R-HSA-936837	Ion transport by P-type ATPases	9.96	1.09e-04	0.008512	5/24	ATP2B4; CAMK2B; FXYD6; CALM1
R-HSA-418346	Platelet homeostasis	9.56	2.72e-05	0.003170	6/30	GNG5; ATP2B4; GNG3; CALM1; PDE9A
R-HSA-5576891	Cardiac conduction	9.56	5.52e-06	0.001253	7/35	ATP2B4; RYR2; SCN9A; CAMK2B; FXYD6; CALM1
R-HSA-397014	Muscle contraction	6.96	1.38e-05	0.002373	8/55	ATP2B4; RYR2; SCN9A; MYL1; CAMK2B; FXYD6; CALM1
R-HSA-418594	G alpha (i) signalling events	6.62	5.82e-06	0.001253	9/65	GNG5; RGS16; SST; GABBR2; GNG3; GAL; CALM1; SSTR2
R-HSA-112314	Neurotransmitter receptors and postsynaptic signal transmission	5.86	4.67e-04	0.028728	6/49	GNG5; CAMK2B; GABBR2; GNG3; CALM1
R-HSA-388396	GPCR downstream signalling	4.54	2.13e-05	0.003061	11/116	GNG5; RGS16; RGS2; SST; GABBR2; GNG3; GAL; CALM1; SSTR2; PTH2
R-HSA-372790	Signaling by GPCR	4.38	2.95e-05	0.003170	11/120	GNG5; RGS16; RGS2; SST; GABBR2; GNG3; GAL; CALM1; SSTR2; PTH2
R-HSA-109582	Hemostasis	3.49	5.99e-05	0.005732	13/178	PRKCZ; GNG5; ATP2B4; H3F3A; ACTB; TMSB4X; GNG3; TUBA1A; CALM1; KIF19; LGALS3BP; PDE9A

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Summary:

Factor	1	2	3	4	5	6	7	8	9	10
Signif_GO_terms	165	217	33	48	152	2	54	37	36	0
Factor	11	12	13	14	15	16	17	18	19	20
Signif_GO_terms	62	0	1	0	1	38	7	33	37	14

6 Gene Set Enrichment Analysis by Perturbation

Target genes: Genes w/ LFSR < 0.05 under each perturbation marker gene;
Backgroud genes: all 6000 genes used in factor analysis;
Statistical test: hypergeometric test (over-representation test);
Only GO terms/pathways that satisfy fold change \(\geq\) 2 and test FDR \(<\) 0.05 are shown below.

6.1 GO Slim Over-Representation Analysis

Gene sets: Gene ontology "Biological Process" (non-redundant).

ADNP : 25 significant GO terms

GeneSet	description	enrichRatio	pValue	FDR	GeneRatio	geneSymbols
GO:0007218	neuropeptide signaling pathway	4.48	7.36e-04	2.25e-02	6/10	PCSK1N; GAL; SCG5; NMB; SSTR2; PTH2
GO:0070972	protein localization to endoplasmic reticulum	4.14	0.00e+00	0.00e+00	66/119	RPL22; RPL11; RPS8; RPL5; RYR2; RTN4; RPS27A; RPL31; RPL37A; RPL32; RPL15; RPSA; RPL14; RPL35A; RPL9; RPL34; ANK2; RPS3A; RPS23; RPS14; RPS10; RPS12; RPS4X; RPL36A; BCAP31; RPL10; RPL7; RPL30; GPAA1; RPS6; RPL35; HSPA5; RPL7A; RPL27A; RPS13; SPCS2; RPS24; RPS26; RPL41; RPL6; RPLP0; RPL21; RPS29; SRP14; RPL4; RPLP1; RPS17; RPS2; RPS15A; RPL13; RPL26; RPL23A; RPL19; RPL27; VAPA; DDRGK1; RPS15; RPS28; RPL18A; RPS16; RPS19; KDELR1; RPL18; RPL13A; RPS5; RPL3
GO:0070670	response to interleukin-4	4.07	1.44e-03	3.64e-02	6/11	HSPA5; TUBA1B; CDK4; CORO1A; XBP1; RPL3
GO:0060191	regulation of lipase activity	3.14	1.93e-03	4.42e-02	8/19	PRKCZ; HPCA; RGS2; AGT; ARF4; SNCA; NTF3; BICD1
GO:0002576	platelet degranulation	2.90	1.15e-04	5.29e-03	14/36	TAGLN2; TUBA4A; MANF; WDR1; SPARC; MAGED2; APLP2; PSAP; VCL; CD63; SCG3; ALDOA; LGALS3BP; SOD1
GO:0008037	cell recognition	2.90	1.15e-04	5.29e-03	14/36	CNTN2; RTN4; CCT7; ROBO1; GAP43; CASP3; CCT5; TCP1; CADM1; VDAC2; ALDOA; CORO1A; EFNB3; BSG
GO:0006413	translational initiation	2.80	7.77e-15	1.90e-12	59/157	RPL22; RPL11; RPS8; RPL5; RPS27A; RPL31; RPL37A; RPL32; RPL15; RPSA; RPL14; RPL35A; RPL9; RPL34; RPS3A; RPS23; RPS14; RPS10; RPS12; RPS4X; RPL36A; RPL10; EIF4EBP1; RPL7; RPL30; RPS6; RPL35; RPL7A; RPL27A; RPS13; PPP1CA; RPS24; RPS26; RPL41; RPL6; RPLP0; DENR; RPL21; RPS29; RPL4; RPLP1; RPS17; RPS2; RPS15A; RPL13; RPL26; RPL23A; RPL19; RPL27; EIF2S2; RPS15; RPS28; RPL18A; RPS16; RPS19; RPL18; RPL13A; RPS5; RPL3
GO:0090150	establishment of protein localization to membrane	2.71	0.00e+00	0.00e+00	74/204	RPL22; RPL11; HPCA; RPS8; RPL5; ATP1B1; YWHAQ; RPS27A; REEP1; RPL31; RPL37A; RPL32; RPL15; RPSA; RPL14; RPL35A; CPLX1; NSG1; RPL9; RPL34; RPS3A; RPS23; RPS14; RPS10; RPS12; RPS4X; RPL36A; RPL10; SDCBP; RPL7; RPL30; RPS6; RPL35; RPL7A; RPL27A; RPS13; ANK3; RPS24; CACNB3; RPS26; RPL41; RPL6; RPLP0; RPL21; RPS29; HSP90AA1; SRP14; RAB11A; RPL4; RPLP1; RPS17; RPS2; RAB26; RPS15A; ARL6IP1; RPL13; YWHAE; RPL26; RPL23A; RPL19; RPL27; SNAP25; YWHAB; RPS15; RPS28; RPL18A; NDUFA13; RPS16; RPS19; RPL18; RPL13A; RPS5; RPL3; WRB
GO:0014074	response to purine-containing compound	2.68	3.11e-04	1.20e-02	14/39	SEPN1; JUN; RYR2; IGFBP5; SPARC; HDAC2; EZR; AKAP9; HSPA5; RAPGEF1; LDHA; HSP90B1; BSG; SOD1
GO:0048857	neural nucleus development	2.65	1.53e-03	3.73e-02	11/31	CDC42; ATP5F1; YWHAQ; G6PD; NFIB; HSPA5; SUDS3; DYNLL1; CKB; YWHAE; ATP5J
GO:0046683	response to organophosphorus	2.63	9.92e-04	2.60e-02	12/34	JUN; IGFBP5; SPARC; EZR; AKAP9; HSPA5; RAPGEF1; LDHA; AKR1C1; HSP90B1; BSG; SOD1
GO:0098742	cell-cell adhesion via plasma-membrane adhesion molecules	2.61	4.21e-04	1.47e-02	14/40	PTPRF; CNTN2; NRXN1; PTPRG; ROBO1; ALCAM; MDGA1; CADM1; PCDH17; PCDH9; PKD1; CBLN1; BSG; PVRL2
GO:0002181	cytoplasmic translation	2.45	1.38e-05	1.01e-03	24/73	RPL11; RPL31; RPL32; RPL15; RPL35A; RPL9; RPS23; RPL36A; EIF4EBP1; RPL30; ZNF385A; RPS26; RPL41; RPL6; RPLP0; DENR; RPS29; RPLP1; RPL26; RPL19; RPS28; RPL18A; RPL18; RPL13A
GO:0010959	regulation of metal ion transport	2.41	7.85e-07	7.20e-05	32/99	SEPN1; HPCA; NOS1AP; ATP1B1; AGT; RYR2; GNAI2; ATP1B3; SNCA; ANK2; CAMK2D; GLRX; TSPAN13; CAMK2B; SRI; AKAP9; G6PD; CHD7; GAL; FXYD6; KIF5B; ANK3; KCNIP2; CACNB3; CD63; JPH4; B2M; CORO1A; YWHAE; NKAIN4; FXYD1; FXYD7
GO:0031099	regeneration	2.36	2.90e-04	1.18e-02	18/57	SEPN1; PTPRF; JUN; GPX1; GAP43; CSNK2B; MTPN; NEFL; NINJ1; TNC; GSTP1; CDK4; PGF; PKM; ENO3; RPL19; RPS16; RTN4R
GO:0003012	muscle system process	2.33	5.94e-07	6.56e-05	35/112	ENO1; TPM3; NOS1AP; ATP1B1; RGS2; AGT; RYR2; CHRNA1; IGFBP5; ANK2; CAMK2D; SORBS2; COL4A3BP; ANXA6; HDAC2; CAMK2B; SRI; CALD1; MTPN; G6PD; TPM2; VCL; KCNIP2; MYL6B; MYL6; ACTC1; ALDOA; SSTR2; MYL12A; MYL12B; TNNC2; TPM4; FXYD1; SOD1; PDE9A
GO:0034765	regulation of ion transmembrane transport	2.30	6.25e-07	6.56e-05	36/117	SEPN1; HPCA; NOS1AP; ATP1B1; RGS2; AGT; RYR2; YWHAQ; SCN3A; ARL6IP5; ATP1B3; WDR1; SNCA; ANK2; CAMK2D; GLRX; CLIC1; TSPAN13; SRI; AKAP9; G6PD; CHD7; GAL; FXYD6; KIF5B; ANK3; KCNIP2; CACNB3; CD63; JPH4; ARL6IP1; CORO1A; YWHAE; CACNA1A; FXYD1; FXYD7
GO:0072524	pyridine-containing compound metabolic process	2.17	9.02e-04	2.45e-02	18/62	ENO1; MDH1; TKT; PDHB; MDH2; PDHA1; PGK1; G6PD; TALDO1; LDHA; PGAM1; TPI1; PKM; IDH2; QPRT; ALDOA; ENO3; DCXR
GO:0034764	positive regulation of transmembrane transport	2.15	7.34e-04	2.25e-02	19/66	NOS1AP; ATP1B1; AGT; RYR2; CAPN10; ATP1B3; SNCA; ANK2; GLRX; SRI; AKAP9; G6PD; GAL; KIF5B; ANK3; KCNIP2; CACNB3; ARL6IP1; FXYD1
GO:0032409	regulation of transporter activity	2.12	2.62e-04	1.13e-02	23/81	SEPN1; HPCA; NOS1AP; ATP1B1; RYR2; ATP1B3; SNCA; ANK2; CAMK2D; GLRX; NDFIP1; SRI; AKAP9; GAL; FXYD6; KIF5B; ANK3; KCNIP2; CACNB3; JPH4; YWHAE; FXYD1; FXYD7
GO:0009410	response to xenobiotic stimulus	2.09	5.91e-04	1.97e-02	21/75	SEPN1; HPCA; GSTM3; PHGDH; MGST3; RGS2; EPHX1; RYR2; GPX1; SNCA; MGST2; HDAC2; EIF4EBP1; FBXO32; HSPA5; GSTP1; AKR1C1; RGS10; ASIC1; SERPINF1; SOD1
GO:0006401	RNA catabolic process	2.09	1.02e-09	1.49e-07	66/236	RPL22; RPL11; YBX1; RPS8; RPL5; RPS27A; RPL31; SSB; RPL37A; RPL32; RPL15; RPSA; RPL14; RPL35A; RPL9; RPL34; RPS3A; RPS23; RPS14; RPS10; RPS12; RPS4X; RPL36A; RPL10; RPL7; RPL30; RPS6; RPL35; SET; RPL7A; RNH1; RPL27A; RPS13; RNASEH2C; HSPA8; RPS24; MAGOHB; RPS26; RPL41; CNOT2; RPL6; RPLP0; UBC; RPL21; RPS29; RPL4; RPLP1; RPS17; RPS2; RPS15A; RPL13; RPL26; RPL23A; RPL19; RPL27; EIF4A3; YWHAB; RPS15; RPS28; RPL18A; RPS16; RPS19; RPL18; RPL13A; RPS5; RPL3
GO:0042391	regulation of membrane potential	2.05	2.65e-05	1.77e-03	33/120	PRKCZ; JUN; NOS1AP; ATP1B1; RYR2; NRXN1; SCN3A; CHRNA1; ARL6IP5; ATP1B3; WDR1; SNCA; ANK2; CAMK2D; GLRX; CLIC1; HEBP2; STX1A; SRI; AKAP9; KIF5B; ANK3; KCNIP2; CACNB3; ASIC1; CBLN1; YWHAE; EIF4A3; BAIAP2; CELF4; CACNA1A; FXYD1; SOD1
GO:0008544	epidermis development	2.04	1.99e-03	4.42e-02	18/66	POU3F1; CRABP2; PKP4; KLF7; IGFBP5; SATB1; CASP3; H2AFY; FAM65B; HDAC2; NSDHL; AGPAT2; TSG101; GAL; PSAP; PPHLN1; CAPNS1; SOD1
GO:0006605	protein targeting	2.03	8.60e-10	1.49e-07	71/261	RPL22; RPL11; HPCA; RPS8; RPL5; RPS27A; RPL31; RPL37A; RPL32; RPL15; RPSA; RPL14; RAB7A; RPL35A; RPL9; RPL34; RPS3A; RPS23; RPS14; RPS10; RPS12; SLC25A6; RPS4X; RPL36A; RPL10; SDCBP; RPL7; RPL30; RPS6; RPL35; RPL7A; RPL27A; RPS13; SPCS2; HSPA8; ANK3; RPS24; CACNB3; RPS26; RPL41; RPL6; RPLP0; UBC; RPL21; RPS29; HSP90AA1; SRP14; RPL4; RPLP1; RPS17; RPS2; RPS15A; ARL6IP1; UQCRC2; RPL13; RPL26; RPL23A; RPL19; RPL27; YWHAB; RPS15; RPS28; RPL18A; NDUFA13; ECH1; RPS16; RPS19; RPL18; RPL13A; RPS5; RPL3

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ARID1B : 20 significant GO terms

GeneSet	description	enrichRatio	pValue	FDR	GeneRatio	geneSymbols
GO:0070972	protein localization to endoplasmic reticulum	7.10	0.00e+00	0.00e+00	51/119	RPL11; RPS8; RPL5; RPS27; RPS27A; RPL37A; RPL32; RPL15; RPSA; SPCS1; RPL9; RPS3A; RPL37; RPS23; RPS14; RPS18; RPL10A; RPS12; SEC61G; RPS4X; RPL36A; RPL39; RPS20; RPL7; RPL30; RPS6; SEC61B; RPL7A; RPL27A; RPS13; RPS3; RPS24; RPS26; RPL6; RPLP0; RPL21; SRP14; RPL4; RPS17; RPS2; RPS15A; RPL13; RPL26; RPL23A; RPL23; RPL19; RPL18A; RPS19; RPL18; RPL13A; RPL3
GO:0010257	NADH dehydrogenase complex assembly	6.62	1.11e-14	8.15e-13	24/60	NDUFS5; NDUFB3; NDUFAF3; NDUFB4; NDUFA2; NDUFB2; NDUFB11; NDUFA1; NDUFB9; TMEM261; NDUFB6; NDUFS8; NDUFC2; NDUFB8; NDUFB1; NDUFB10; NDUFS7; NDUFA11; NDUFA7; NDUFB7; NDUFA13; NDUFA3; NDUFA6; MT-ND3
GO:0006413	translational initiation	5.91	0.00e+00	0.00e+00	56/157	RPL11; RPS8; RPL5; RPS27; DDX1; RPS27A; RPL37A; RPL32; RPL15; RPSA; RPL9; RPS3A; RPL37; RPS23; RPS14; RPS18; RPL10A; RPS12; RPS4X; RPL36A; RPL39; MCTS1; EIF4EBP1; RPS20; RPL7; RPL30; EIF3E; EIF3H; RPS6; RPL7A; EIF3F; RPL27A; RPS13; RPS3; RPS24; RPS26; RPL6; RPLP0; RPL21; RPL4; RPS17; RPS2; RPS15A; RPL13; RPL26; RPL23A; RPL23; RPL19; EIF1; RPL18A; RPS19; RPL18; RPL13A; EIF3L; RPL3; ATF4
GO:0033108	mitochondrial respiratory chain complex assembly	5.90	0.00e+00	0.00e+00	31/87	NDUFS5; COX20; NDUFB3; NDUFAF3; COX17; NDUFB4; NDUFA2; NDUFB2; NDUFB11; NDUFA1; NDUFB9; TMEM261; NDUFB6; NDUFS8; NDUFC2; NDUFB8; COX14; COX16; NDUFB1; NDUFB10; COA3; NDUFS7; NDUFA11; PET100; NDUFA7; NDUFB7; NDUFA13; NDUFA3; UQCR10; NDUFA6; MT-ND3
GO:0002181	cytoplasmic translation	5.44	1.79e-12	1.01e-10	24/73	RPL11; RPL32; RPL15; TMA7; RPL9; RPS23; RPL10A; RPL36A; RPL39; MCTS1; EIF4EBP1; RPL30; EIF3E; EIF3H; EIF3F; RPS26; RPL6; RPLP0; RPL26; RPL19; RPL18A; RPL18; RPL13A; EIF3L
GO:1902600	proton transmembrane transport	5.38	8.32e-13	5.09e-11	25/77	PARK7; COX5B; ATP5G3; COX17; ATP5I; COX7C; COX7A2; NDUFA4; ATP5J2; ATP6V1F; TMSB4X; COX7B; COX6C; COX8A; ATP5L; ATP5G2; COX5A; COX4I1; ATP5G1; ATP5H; ATP5E; NDUFS7; COX6B1; ATP5J; MT-CO1
GO:0090150	establishment of protein localization to membrane	4.71	0.00e+00	0.00e+00	58/204	RPL11; RPS8; RPL5; RPS27; RPS27A; RPL37A; RPL32; RPL15; RPSA; RPL9; RPS3A; RPL37; RPS23; RPS14; GNB2L1; RPS18; RPL10A; CD24; RPS12; FIS1; RPS4X; RPL36A; RPL39; RPS20; RPL7; RPL30; YWHAZ; RPS6; SEC61B; RPL7A; RPL27A; RPS13; TIMM10; RPS3; RPS24; RPS26; RPL6; RPLP0; RPL21; CALM1; SRP14; RPL4; RPS17; RPS2; RPS15A; RPL13; RPL26; RPL23A; RPL23; RPL19; ROMO1; RPL18A; NDUFA13; PDCD5; RPS19; RPL18; RPL13A; RPL3
GO:0017004	cytochrome complex assembly	4.14	1.07e-03	4.15e-02	7/28	COX20; COX17; COX14; COX16; COA3; PET100; UQCR10
GO:0009141	nucleoside triphosphate metabolic process	4.12	0.00e+00	0.00e+00	47/189	PARK7; ATPIF1; NDUFS5; UQCRH; COX5B; ATP5G3; NDUFB3; NDUFB4; ATP5I; COX7C; UQCRQ; NDUFA2; COX7A2; NDUFA4; CYCS; ATP5J2; NDUFB2; TMSB4X; NDUFA1; NDUFB9; NDUFB6; AK1; NDUFS8; NDUFC2; ATP5L; NDUFB8; TPI1; ATP5G2; DNAJC15; NDUFB1; COX5A; NDUFB10; DCTPP1; COX4I1; ATP5G1; NME1; ATP5H; ATP5E; NDUFS7; NDUFA7; NDUFB7; NDUFA3; UQCR10; NDUFA6; ATP5J; MT-CO1; MT-ND3
GO:0006605	protein targeting	3.93	0.00e+00	0.00e+00	62/261	RPL11; ATPIF1; RPS8; RPL5; RPS27; RPS27A; RPL37A; RPL32; RPL15; RPSA; SPCS1; RPL9; RPS3A; RPL37; RPS23; RPS14; RPS18; RPL10A; RPS12; SEC61G; FIS1; RPS4X; RPL36A; RPL39; RPS20; RPL7; RPL30; YWHAZ; RPS6; SEC61B; RPL7A; RPL27A; RPS13; IMMP1L; TIMM10; RPS3; TIMM8B; RPS24; RPS26; RPL6; RPLP0; RPL21; DNAJC15; SRP14; RPL4; RPS17; RPS2; RPS15A; RPL13; RPL26; RPL23A; RPL23; RPL19; ROMO1; UBL5; RPL18A; NDUFA13; PDCD5; RPS19; RPL18; RPL13A; RPL3
GO:0009123	nucleoside monophosphate metabolic process	3.91	1.11e-16	9.05e-15	46/195	PARK7; ATPIF1; NDUFS5; UQCRH; COX5B; ATP5G3; NDUFB3; NDUFB4; ATP5I; COX7C; UQCRQ; NDUFA2; COX7A2; HDDC2; NDUFA4; CYCS; ATP5J2; NDUFB2; TMSB4X; NDUFA1; NDUFB9; NDUFB6; AK1; NDUFS8; NDUFC2; ATP5L; NDUFB8; TPI1; ATP5G2; DNAJC15; NDUFB1; COX5A; NDUFB10; COX4I1; ATP5G1; ATP5H; ATP5E; NDUFS7; NDUFA7; NDUFB7; NDUFA3; UQCR10; NDUFA6; ATP5J; MT-CO1; MT-ND3
GO:0006401	RNA catabolic process	3.86	0.00e+00	0.00e+00	55/236	RPL11; RPS8; RPL5; RPS27; RPS27A; RPL37A; RPL32; RPL15; RPSA; RPL9; LSM6; RPS3A; RPL37; RPS23; RPS14; RPS18; RPL10A; RPS12; LSM5; LINC01420; RPS4X; RPL36A; RPL39; RPS20; RPL7; RPL30; YWHAZ; EIF3E; RPS6; RPL7A; RPL27A; RPS13; RNASEH2C; RPS3; RPS24; RPS26; RPL6; RPLP0; RPL21; RPL4; RPS17; RPS2; RPS15A; RPL13; RPL26; RPL23A; RPL23; RPL19; DDX5; RPL18A; LSM4; RPS19; RPL18; RPL13A; RPL3
GO:0006091	generation of precursor metabolites and energy	3.54	0.00e+00	0.00e+00	53/248	PARK7; SH3BGRL3; ATPIF1; NDUFS5; UQCRH; COX20; COX5B; NDUFB3; COX17; NDUFB4; ATP5I; COX7C; GLRX; UQCRQ; NDUFA2; COX7A2; NDUFA4; CYCS; ATP5J2; NDUFB2; COX7B; NDUFA1; COX6C; NDUFB9; NDUFB6; COX8A; NDUFS8; NDUFC2; ATP5L; CISD1; NDUFB8; TPI1; BLOC1S1; HMGB1; DNAJC15; NDUFB1; COX5A; NDUFB10; COX4I1; ATP5H; GNAS; ATP5E; NDUFS7; UQCR11; NDUFA7; NDUFB7; COX6B1; NDUFA3; UQCR10; NDUFA6; ATP5J; MT-CO1; MT-ND3
GO:0007006	mitochondrial membrane organization	3.27	1.06e-05	5.54e-04	17/86	ATPIF1; ATP5G3; ATP5I; DYNLT1; ATP5J2; YWHAZ; TIMM10; ATP5L; ATP5G2; CALM1; ATP5G1; ATP5H; ROMO1; ATP5E; NDUFA13; PDCD5; ATP5J
GO:0009259	ribonucleotide metabolic process	3.09	4.32e-13	2.88e-11	48/257	PARK7; ATPIF1; NDUFS5; UQCRH; COX5B; DBI; ATP5G3; NDUFB3; NDUFB4; ATP5I; COX7C; HINT1; UQCRQ; NDUFA2; COX7A2; NDUFA4; CYCS; ATP5J2; NDUFB2; TMSB4X; NDUFA1; NDUFB9; NDUFB6; AK1; NDUFS8; NDUFC2; ATP5L; NDUFB8; TPI1; ATP5G2; DNAJC15; NDUFB1; COX5A; NDUFB10; COX4I1; ATP5G1; NME1; ATP5H; ATP5E; NDUFS7; NDUFA7; NDUFB7; NDUFA3; UQCR10; NDUFA6; ATP5J; MT-CO1; MT-ND3
GO:0071826	ribonucleoprotein complex subunit organization	2.42	1.30e-05	5.94e-04	27/185	MRPL20; RPL11; RPL5; RPS27; SNRPE; DDX1; SNRPG; RPSA; RPS23; RPS14; LINC01420; MCTS1; EIF3E; EIF3H; EIF3F; SNRPF; RPL6; RPLP0; RPL23A; SNRPD1; LSM4; RPS19; SNRPD2; RPL13A; EIF3L; RPL3; SNU13
GO:0006839	mitochondrial transport	2.25	4.62e-04	2.00e-02	20/147	ATPIF1; COX5B; ATP5I; DYNLT1; ATP5J2; FIS1; YWHAZ; IMMP1L; TIMM10; TIMM8B; ATP5L; DNAJC15; ATP5H; ROMO1; ATP5E; UBL5; NDUFA13; PDCD5; SMDT1; ATP5J
GO:0006979	response to oxidative stress	2.04	1.01e-03	4.10e-02	22/179	PARK7; PRDX1; TXNIP; SELK; NDUFB4; ATOX1; GNB2L1; CYCS; TXN; PRDX5; GSTP1; NDUFS8; RPS3; PEBP1; ROMO1; GPX4; PRDX2; ATF4; NDUFA6; SOD1; MT-CO1; MT-ND3
GO:0016072	rRNA metabolic process	2.03	1.32e-03	4.84e-02	21/171	RPL11; RPS8; RPL5; RPS27; NCL; RPSA; LSM6; RPS14; NHP2; RPL10A; GTF2H5; RPL7; RPS6; RPL7A; RPS24; NOP10; RPS17; RPS2; RPL26; RPS19; SNU13
GO:0022613	ribonucleoprotein complex biogenesis	2.01	1.17e-05	5.73e-04	40/330	MRPL20; RPL11; RPS8; RPL5; RPS27; SNRPE; DDX1; SNRPG; RPSA; LSM6; RPS23; RPS14; NHP2; RPL10A; GTF2H5; LINC01420; MCTS1; RPL7; EIF3E; EIF3H; RPS6; RPL7A; EIF3F; RPS24; SNRPF; RPL6; RPLP0; NOP10; RPS17; RPS2; RPL26; RPL23A; SNRPD1; LSM4; RPS19; SNRPD2; RPL13A; EIF3L; RPL3; SNU13

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ASH1L : 33 significant GO terms

GeneSet	description	enrichRatio	pValue	FDR	GeneRatio	geneSymbols
GO:0010737	protein kinase A signaling	7.76	2.29e-04	1.29e-02	5/11	RAB13; AKAP12; EZR; GAL; AKAP6
GO:0007218	neuropeptide signaling pathway	6.83	1.83e-03	4.19e-02	4/10	PCSK1N; GAL; SSTR2; PTH2
GO:0010644	cell communication by electrical coupling	6.57	5.80e-04	2.36e-02	5/13	ATP1B1; RYR2; SRI; ANK3; CALM1
GO:0015844	monoamine transport	6.03	2.73e-04	1.34e-02	6/17	AGT; SNCA; STX1A; GPM6B; SYT7; SYT1
GO:0060191	regulation of lipase activity	5.39	5.43e-04	2.34e-02	6/19	PRKCZ; HPCA; RHOC; AGT; SNCA; NTF3
GO:0031644	regulation of neurological system process	4.55	2.37e-04	1.29e-02	8/30	PRKCZ; AGT; NRXN1; STX1A; AKAP9; EIF4A3; BAIAP2; CELF4
GO:0014074	response to purine-containing compound	3.94	3.18e-04	1.46e-02	9/39	SEPN1; JUN; RYR2; IGFBP5; HDAC2; EZR; AKAP9; RAPGEF1; AKAP6
GO:0099565	chemical synaptic transmission, postsynaptic	3.90	7.36e-04	2.54e-02	8/35	PRKCZ; NRXN1; CHRNA1; SNCA; STX1A; EIF4A3; BAIAP2; CELF4
GO:0010959	regulation of metal ion transport	3.79	3.29e-08	2.42e-05	22/99	SEPN1; HPCA; NOS1AP; ATP1B1; AGT; RYR2; GNAI2; SNCA; TSPAN13; CAMK2B; SRI; AKAP9; G6PD; CHD7; GAL; ANK3; JPH4; AKAP6; CALM1; NKAIN4; HOMER3; FXYD7
GO:0034764	positive regulation of transmembrane transport	3.62	1.98e-05	2.08e-03	14/66	NOS1AP; ATP1B1; AGT; RYR2; CAPN10; SNCA; SRI; AKAP9; TMSB4X; G6PD; GAL; ANK3; AKAP6; CALM1
GO:0035637	multicellular organismal signaling	3.57	6.89e-04	2.54e-02	9/43	ATP1B1; AGT; RYR2; SCN3A; CHRNA1; SRI; AKAP9; ANK3; CALM1
GO:0034765	regulation of ion transmembrane transport	3.36	1.78e-07	6.55e-05	23/117	SEPN1; HPCA; NOS1AP; ATP1B1; AGT; RYR2; SCN3A; SNCA; CLIC1; TSPAN13; SRI; AKAP9; TMSB4X; G6PD; CHD7; GAL; ANK3; JPH4; AKAP6; CALM1; CACNA1A; FXYD7; KCNJ6
GO:0043270	positive regulation of ion transport	3.26	1.23e-04	8.22e-03	13/68	NOS1AP; ATP1B1; AGT; RYR2; SNCA; SRI; AKAP9; TMSB4X; G6PD; GAL; ANK3; AKAP6; CALM1
GO:0061351	neural precursor cell proliferation	3.22	8.34e-04	2.66e-02	10/53	GNG5; ID2; SIX3; GNAI2; RAPGEF1; ILK; EMX2; NEUROD4; NAP1L1; INSM1
GO:0032409	regulation of transporter activity	3.16	5.49e-05	5.04e-03	15/81	SEPN1; HPCA; NOS1AP; ATP1B1; RYR2; SNCA; SRI; AKAP9; TMSB4X; GAL; ANK3; JPH4; AKAP6; CALM1; FXYD7
GO:0072511	divalent inorganic cation transport	3.00	7.40e-06	9.05e-04	20/114	SEPN1; HPCA; NOS1AP; ATP1B1; AGT; RYR2; GNAI2; SNCA; GPM6A; TSPAN13; CAMK2B; SRI; G6PD; CHD7; ASIC1; JPH4; AKAP6; CALM1; CACNA1A; HOMER3
GO:0042391	regulation of membrane potential	2.99	4.53e-06	6.65e-04	21/120	PRKCZ; JUN; NOS1AP; ATP1B1; RYR2; NRXN1; SCN3A; CHRNA1; SNCA; GNB2L1; CLIC1; STX1A; SRI; AKAP9; ANK3; ASIC1; AKAP6; EIF4A3; BAIAP2; CELF4; CACNA1A
GO:0099177	regulation of trans-synaptic signaling	2.92	5.02e-07	1.23e-04	26/152	PRKCZ; AGT; NRXN1; GNAI2; ABHD6; NSG1; SNCA; CPLX2; GRM4; AKAP12; CAMK2B; STX1A; AKAP9; SYT7; NTF3; ASIC1; SYT1; JPH4; CALM1; RAB26; EFNB3; EIF4A3; BAIAP2; CELF4; CACNA1A; RAB3A
GO:0019932	second-messenger-mediated signaling	2.78	2.46e-04	1.29e-02	15/92	SEPN1; HPCA; NOS1AP; ATP1B1; AGT; RYR2; NEUROD1; GNAI2; SRI; GAL; JPH4; AKAP6; CALM1; HOMER3; APLP1
GO:0009410	response to xenobiotic stimulus	2.73	1.21e-03	3.42e-02	12/75	SEPN1; HPCA; RYR2; GPX1; SNCA; NR3C1; HSP90AB1; GSTA4; HDAC2; GSTP1; ASIC1; CALM1
GO:0009914	hormone transport	2.52	1.64e-03	4.01e-02	13/88	AGT; SOX11; NEUROD1; KLF7; CAPN10; STX1A; SRI; SLC25A6; CHD7; SYT7; GAL; CACNA1A; SELM
GO:0001503	ossification	2.52	1.12e-03	3.29e-02	14/95	PBX1; H3F3A; SOX11; ID2; IGFBP5; PDLIM7; CLIC1; FZD1; GPM6B; RBMX; CTHRC1; TNC; ILK; TP53INP2
GO:0060560	developmental growth involved in morphogenesis	2.49	1.82e-03	4.19e-02	13/89	PRKCZ; CRABP2; MAP2; ALCAM; HSP90AB1; AUTS2; DPYSL2; TNC; ILK; GAL; SYT1; RND2; RTN4R
GO:0061564	axon development	2.47	2.55e-06	4.67e-04	30/207	STMN1; PTPRF; JUN; S100A6; CRABP2; LHX9; NRXN1; KLF7; MAP2; ALCAM; SPON2; CASP3; PDLIM7; HSP90AB1; EZR; AUTS2; NEFM; NEFL; DPYSL2; TNC; ILK; FEZ1; ANK3; MYCBP2; EFNB3; RND2; NGFR; BAIAP2; RAB3A; RTN4R
GO:0003012	muscle system process	2.44	7.16e-04	2.54e-02	16/112	NOS1AP; ATP1B1; AGT; RYR2; CHRNA1; IGFBP5; HDAC2; CAMK2B; SRI; CALD1; G6PD; AKAP6; CALM1; ALDOA; SSTR2; EEF2
GO:0051047	positive regulation of secretion	2.44	1.05e-03	3.20e-02	15/105	PRKCZ; WLS; AGT; SOX11; CAPN10; GNAI2; SNCA; EZR; STX1A; SRI; SYT7; GAL; GAPDH; SYT1; RAB3A
GO:0048880	sensory system development	2.44	1.53e-03	4.00e-02	14/98	HPCA; JUN; SOX11; SIX3; NEUROD1; IMPDH2; MAB21L2; GPM6A; HDAC2; CHD7; ZEB1; NEUROD4; MAB21L1; CELF4
GO:0023061	signal release	2.36	1.20e-04	8.22e-03	22/159	WLS; AGT; SOX11; NRXN1; NEUROD1; KLF7; CAPN10; SNCA; CPLX2; GRM4; STX1A; SRI; SLC25A6; CHD7; SYT7; GAL; ASIC1; SYT1; CALM1; CACNA1A; RAB3A; SELM
GO:0002791	regulation of peptide secretion	2.27	2.22e-03	4.95e-02	15/113	PRKCZ; WLS; NEUROD1; KLF7; CAPN10; BTN2A2; EZR; STX1A; SRI; SLC25A6; TMSB4X; CHD7; SYT7; GAPDH; CACNA1A
GO:0010975	regulation of neuron projection development	2.21	9.22e-05	7.52e-03	26/201	ACAP3; PTPRF; CRABP2; AGT; MAP2; ITM2C; PTPRG; TNIK; ENC1; NR2F1; HDAC2; CAMK2B; FZD1; NEFL; DPYSL2; RAPGEF1; ILK; CFL1; SYT1; MYCBP2; EFNB3; RND2; NGFR; BAIAP2; PREX1; RTN4R
GO:0009636	response to toxic substance	2.12	7.60e-04	2.54e-02	21/169	HPCA; JUN; CHRNA1; EEF1B2; GPX1; CASP3; GNB2L1; HDAC2; G6PD; NEFL; TNC; GSTP1; RPS3; FAM213A; ASIC1; HNRNPA1; ESD; CALM1; SNN; EEF2; PRDX2
GO:0051098	regulation of binding	2.06	1.49e-03	4.00e-02	20/166	STMN1; PTPRF; JUN; NUCKS1; SOX11; ID2; NEUROD1; MAP2; HMGB2; MDFI; HSP90AB1; HDAC2; SRI; TMSB4X; CTHRC1; CALM1; CCPG1; EIF4A3; AES; MFNG
GO:0050769	positive regulation of neurogenesis	2.05	1.61e-03	4.01e-02	20/167	CRABP2; AGT; SOX11; ID2; NEUROD1; ENC1; HDAC2; CAMK2B; FZD1; NEFL; RAPGEF1; ILK; ZEB1; NAP1L1; SYT1; TCF12; RND2; NGFR; BAIAP2; PCP4

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CHD2 : 21 significant GO terms

GeneSet	description	enrichRatio	pValue	FDR	GeneRatio	geneSymbols
GO:0007218	neuropeptide signaling pathway	4.51	7.06e-04	2.16e-02	6/10	PCSK1N; GAL; SCG5; NMB; SSTR2; PTH2
GO:0070972	protein localization to endoplasmic reticulum	4.36	0.00e+00	0.00e+00	69/119	RPL22; RPL11; RPS8; RPL5; RPS27; RYR2; RPS27A; RPL31; RPL37A; RPL32; RPL15; RPSA; RPL14; SPCS1; RPL24; RPL35A; RPL9; RPL34; RPS3A; RPL37; RPS23; RPS14; RPS10; SEC63; RPS12; SEC61G; RPS4X; RPL36A; RPL39; RPL10; RPS20; RPL7; RPL30; RPL8; RPS6; SEC61B; HSPA5; RPL7A; RPL27A; RPS13; RPS3; RPS24; RPL41; RPL6; RPLP0; RPL21; RPS29; SRP14; RPL4; RPLP1; RPS17; RPS15A; RPL13; RPL26; RPL23A; RPL23; RPL19; RPL27; RPL38; RPL17; RPS15; RPS28; RPL18A; RPS16; RPS19; RPL18; RPL13A; RPS5; RPL3
GO:0002181	cytoplasmic translation	3.40	1.93e-11	2.36e-09	33/73	RPL11; RPL31; RPL32; RPL15; RPL24; RPL35A; RPL9; RPS23; RPL36A; RPL39; RPL30; EIF3E; EIF3H; RPL8; EIF3F; ZNF385A; RPL41; RPL6; RPLP0; DENR; RPS29; EIF3J; RPLP1; RPL26; RPL19; RPL38; RPL17; EEF2; RPS28; RPL18A; RPL18; RPL13A; EIF3L
GO:0006413	translational initiation	3.30	0.00e+00	0.00e+00	69/157	RPL22; RPL11; RPS8; RPL5; RPS27; DDX1; RPS27A; RPL31; RPL37A; RPL32; RPL15; RPSA; RPL14; RPL24; RPL35A; RPL9; RPL34; RPS3A; RPL37; RPS23; RPS14; RPS10; RPS12; RPS4X; RPL36A; RPL39; RPL10; RPS20; RPL7; RPL30; EIF3E; EIF3H; RPL8; RPS6; RPL7A; EIF3F; RPL27A; RPS13; RPS3; RPS24; RPL41; RPL6; RPLP0; DENR; RPL21; RPS29; EIF3J; RPL4; RPLP1; RPS17; RPS15A; RPL13; RPL26; RPL23A; RPL23; RPL19; RPL27; RPL38; RPL17; RPS15; RPS28; RPL18A; RPS16; RPS19; RPL18; RPL13A; RPS5; EIF3L; RPL3
GO:0090150	establishment of protein localization to membrane	3.10	0.00e+00	0.00e+00	84/204	RPL22; RPL11; HPCA; RPS8; RPL5; RPS27; ATP1B1; CNST; RPS27A; REEP1; RPL31; RPL37A; RPL32; RPL15; RPSA; RPL14; RPL24; RPL35A; CPLX1; NSG1; RPL9; RPL34; RPS3A; RPL37; RPS23; RPS14; GNB2L1; RPS10; SEC63; RPS12; FIS1; RPS4X; RPL36A; RPL39; RPL10; RPS20; RPL7; RPL30; RPL8; RPS6; SEC61B; RPL7A; RPL27A; RPS13; TIMM10; BAD; RPS3; RPS24; CACNB3; RPL41; RPL6; RPLP0; RPL21; RPS29; CALM1; HSP90AA1; SRP14; RPL4; RPLP1; RPS17; RAB26; RPS15A; RPL13; VAMP2; RPL26; RPL23A; RPL23; RPL19; RPL27; RPL38; RAB31; RPL17; ROMO1; RPS15; RPS28; RPL18A; NDUFA13; PDCD5; RPS16; RPS19; RPL18; RPL13A; RPS5; RPL3
GO:0010257	NADH dehydrogenase complex assembly	3.01	2.03e-07	2.13e-05	24/60	NDUFS5; NDUFAF3; NDUFB4; NDUFA2; NDUFA5; NDUFB2; NDUFB11; NDUFA1; NDUFB9; NDUFS8; NDUFC2; NDUFB8; NDUFB10; NDUFAB1; NDUFA11; NDUFA7; NDUFB7; NDUFA13; NDUFA3; NDUFA6; MT-ND1; MT-ND3; MT-ND4; MT-ND6
GO:0001906	cell killing	2.95	5.30e-04	1.69e-02	11/28	PRDX1; TUBB; RPL30; BAD; CADM1; GAPDH; B2M; EMP2; VAMP2; ROMO1; RPS19
GO:0014074	response to purine-containing compound	2.89	7.00e-05	3.95e-03	15/39	SEPN1; JUN; RYR2; HSPD1; IGFBP5; CDO1; HDAC2; EZR; AKAP9; HSPA5; RAPGEF1; LDHA; HSP90B1; NME1; BSG
GO:0006959	humoral immune response	2.82	2.50e-03	4.96e-02	9/24	SPON2; RPL39; RPL30; SERPING1; GAPDH; C1QBP; PHB; ROMO1; RPS19
GO:0050663	cytokine secretion	2.72	4.41e-04	1.47e-02	13/36	PRKCZ; S100A13; SYT11; AGT; HSPD1; SELK; BTN2A2; EZR; TMSB4X; CADM1; GAPDH; HMGB1; MIF
GO:0050954	sensory perception of mechanical stimulus	2.70	2.87e-04	1.01e-02	14/39	GPX1; CASP3; FAM65B; SOBP; CHD7; NDUFB9; NAV2; TIMM10; TIMM8B; CACNB3; SRRM4; SIX1; RPL38; RAB3A
GO:0046683	response to organophosphorus	2.65	9.26e-04	2.34e-02	12/34	JUN; HSPD1; IGFBP5; CDO1; EZR; AKAP9; HSPA5; RAPGEF1; LDHA; HSP90B1; NME1; BSG
GO:0021953	central nervous system neuron differentiation	2.51	1.21e-04	5.94e-03	18/54	DRAXIN; EPHB2; LMO4; NRP2; MAP2; ROBO1; UQCRQ; ID4; SOX4; MDGA1; FZD1; MTPN; NFIB; MYCBP2; HSP90AA1; CBLN1; DCC; ADARB1
GO:0033108	mitochondrial respiratory chain complex assembly	2.42	3.65e-06	2.98e-04	28/87	NDUFS5; NDUFAF3; COX17; NDUFB4; NDUFA2; UQCC2; NDUFA5; NDUFB2; NDUFB11; NDUFA1; UQCRB; NDUFB9; NDUFS8; NDUFC2; NDUFB8; NDUFB10; NDUFAB1; NDUFA11; PET100; NDUFA7; NDUFB7; NDUFA13; NDUFA3; NDUFA6; MT-ND1; MT-ND3; MT-ND4; MT-ND6
GO:0006401	RNA catabolic process	2.39	3.36e-14	6.00e-12	75/236	RPL22; RPL11; YBX1; RPS8; SERBP1; RPL5; RPS27; RPS27A; RPL31; SSB; RPL37A; RPL32; RPL15; RPSA; RPL14; PCBP4; RPL24; RPL35A; RPL9; RPL34; LSM6; RPS3A; RPL37; RPS23; RPS14; RPS10; RPS12; RPS4X; RPL36A; RPL39; RPL10; RPS20; RPL7; RPL30; EIF3E; RPL8; RPS6; RPL7A; RPL27A; RPS13; RNASEH2C; RPS3; HSPA8; RPS24; RPL41; CNOT2; RPL6; RPLP0; RPL21; HNRNPC; RPS29; RPL4; RPLP1; RPS17; RPS15A; RPL13; RPL26; RPL23A; RPL23; RPL19; RPL27; RPL38; EIF4A3; RPL17; CIRBP; RPS15; LSM7; RPS28; RPL18A; RPS16; RPS19; RPL18; RPL13A; RPS5; RPL3
GO:0006605	protein targeting	2.30	4.09e-14	6.00e-12	80/261	RPL22; RPL11; HPCA; RPS8; RPL5; RPS27; RPS27A; RPL31; HSPD1; RPL37A; RPL32; RPL15; RPSA; RPL14; SPCS1; RPL24; RPL35A; RPL9; RPL34; RPS3A; RPL37; RPS23; RPS14; RPS10; SEC63; RPS12; SEC61G; FIS1; RPS4X; RPL36A; RPL39; RPL10; RPS20; RPL7; RPL30; RPL8; RPS6; SEC61B; RPL7A; RPL27A; RPS13; TIMM10; RPS3; TIMM8B; HSPA8; RPS24; CACNB3; RPL41; RPL6; RPLP0; RPL21; DNAJC15; RPS29; HSP90AA1; SRP14; RPL4; RPLP1; RPS17; RPS15A; RPL13; RPL26; RPL23A; RPL23; RPL19; RPL27; RPL38; RPL17; ROMO1; RPS15; RPS28; UBL5; RPL18A; NDUFA13; PDCD5; RPS16; RPS19; RPL18; RPL13A; RPS5; RPL3
GO:0031099	regeneration	2.24	8.15e-04	2.17e-02	17/57	SEPN1; PTPRF; JUN; FKBP1B; GPX1; GAP43; NREP; MTPN; NEFL; TNC; GSTP1; PKM; ENO3; RPL19; PHB; RPS16; RTN4R
GO:0070661	leukocyte proliferation	2.17	2.36e-03	4.80e-02	15/52	FKBP1B; HSPD1; IGFBP2; SATB1; SELK; CASP3; BTN2A2; RPS6; CD151; GSTP1; GAL; RPS3; CADM1; HMGB1; MIF
GO:0010959	regulation of metal ion transport	2.05	1.46e-04	6.68e-03	27/99	SEPN1; NKAIN1; HPCA; NOS1AP; ATP1B1; AGT; RYR2; FKBP1B; GNAI2; SNCA; TSPAN13; CAMK2B; SRI; AKAP9; CHD7; GAL; FXYD6; KCNIP2; CACNB3; CD63; JPH4; CALM1; B2M; VAMP2; FKBP1A; NKAIN4; FXYD7
GO:1902600	proton transmembrane transport	2.05	7.81e-04	2.17e-02	21/77	COX5B; ATP5G3; COX17; ATP5I; ATP6V1G2; NDUFA4; ATP5J2; TMSB4X; COX7B; COX6C; ATP6V1G1; COX8A; ATP5B; COX5A; ATP5G1; ATP5H; ATP5A1; CYB5A; COX6B1; ATP5J; MT-ND4
GO:0003012	muscle system process	2.01	9.05e-05	4.75e-03	30/112	ENO1; NOS1AP; ATP1B1; RGS2; TNNI1; AGT; RYR2; FKBP1B; MYL1; IGFBP5; SORBS2; COL4A3BP; NEUROG1; ANXA6; HDAC2; CAMK2B; SRI; CALD1; MTPN; VCL; KCNIP2; MYL6B; MYL6; CALM1; ALDOA; SSTR2; MYL12A; MYL12B; EEF2; PDE9A

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DYRK1A : 2 significant GO terms

GeneSet	description	enrichRatio	pValue	FDR	GeneRatio	geneSymbols
GO:0046683	response to organophosphorus	7.55	0.000113	0.0415	6/34	HSPD1; NDUFS4; EZR; HSPA5; LDHA; HSP90B1
GO:0006457	protein folding	4.03	0.000016	0.0117	13/138	PDIA6; FKBP1B; HSPD1; HSPE1; CANX; HSP90AB1; PRDX4; HSPA5; PFDN5; HSP90B1; PDIA3; PPIB; CALR

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PTEN : 22 significant GO terms

GeneSet	description	enrichRatio	pValue	FDR	GeneRatio	geneSymbols
GO:0070972	protein localization to endoplasmic reticulum	4.52	0.00e+00	0.00e+00	84/119	RPL22; RPL11; RPS8; RPL5; RPS27; RYR2; RPS7; RPS27A; RPL31; RPL37A; RPL32; RPL15; RPSA; RPL14; RPL29; RPL24; RPL35A; RPL9; RPL34; RPS3A; RPL37; RPS23; RPS14; RPS18; RPS10; RPL10A; SEC63; RPS12; SEC61G; RPS4X; RPL36A; RPL39; RPL10; RPS20; RPL7; RPL30; RPL8; RPS6; SEC61B; HSPA5; RPL12; RPL7A; RPLP2; RPL27A; RPS13; RPS3; RPS25; RPS24; RPS26; RPL41; RPL6; RPLP0; RPL21; RPS29; SRP14; RPL4; RPLP1; RPS17; RPS2; RPS15A; RPL13; RPL26; RPL23A; RPL23; RPL19; RPL27; RPL38; RPL17; RPS21; RPS15; RPL36; RPS28; RPL18A; UBA52; RPS16; RPS19; KDELR1; RPL18; RPL13A; RPS11; RPS9; RPL28; RPS5; RPL3
GO:0007218	neuropeptide signaling pathway	3.84	1.70e-03	3.37e-02	6/10	PCSK1N; GAL; SCG5; NMB; SSTR2; PTH2
GO:0014075	response to amine	3.84	1.70e-03	3.37e-02	6/10	RGS2; HDAC2; RGS10; ASIC1; CALM1; NME1
GO:0006413	translational initiation	3.75	0.00e+00	0.00e+00	92/157	RPL22; RPL11; RPS8; RPL5; RPS27; RPS7; DDX1; RPS27A; RPL31; RPL37A; RPL32; RPL15; RPSA; RPL14; RPL29; RPL24; EIF4A2; RPL35A; RPL9; RPL34; RPS3A; RPL37; RPS23; RPS14; NPM1; RPS18; RPS10; RPL10A; RPS12; HSPB1; RPS4X; RPL36A; RPL39; RPL10; RPS20; RPL7; RPL30; PABPC1; EIF3E; EIF3H; RPL8; RPS6; RPL12; RPL7A; RPLP2; EIF3F; RPL27A; RPS13; EIF3M; RPS3; RPS25; RPS24; RPS26; RPL41; RPL6; RPLP0; DENR; RPL21; RPS29; EIF3J; RPL4; RPLP1; RPS17; RPS2; RPS15A; RPL13; RPL26; RPL23A; RPL23; RPL19; RPL27; RPL38; RPL17; EIF2S2; RPS21; RPS15; RPL36; RPS28; RPL18A; UBA52; RPS16; RPS19; RPL18; RPL13A; RPS11; RPS9; RPL28; RPS5; EIF3D; EIF3L; RPL3; ATF4
GO:0002181	cytoplasmic translation	3.51	7.99e-15	9.78e-13	40/73	RPL11; RPL31; RPL32; RPL15; TMA7; RPL29; RPL24; RPL35A; RPL9; RPS23; RPL10A; RPL36A; RPL39; RPL30; EIF3E; EIF3H; RPL8; EIF3F; EIF3M; RPS26; RPL41; RPL6; RPLP0; DENR; RPS29; EIF3J; RPLP1; RPL26; RPL19; RPL38; RPL17; RPS21; EEF2; RPL36; RPS28; RPL18A; RPL18; RPL13A; EIF3D; EIF3L
GO:0010644	cell communication by electrical coupling	3.45	1.59e-03	3.34e-02	7/13	ATP1B1; RYR2; FKBP1B; DBN1; SRI; CALM1; HRC
GO:0015844	monoamine transport	3.39	3.92e-04	1.37e-02	9/17	PARK7; SYT11; AGT; SNCA; ACTB; STX1A; GPM6B; SYT7; SNCG
GO:0051339	regulation of lyase activity	3.20	2.76e-03	4.82e-02	7/14	PARK7; HPCA; GNAI2; CAP2; AKAP9; GABBR2; PHPT1
GO:0090150	establishment of protein localization to membrane	3.14	0.00e+00	0.00e+00	100/204	RPL22; RPL11; HPCA; RPS8; RPL5; RPS27; ATP1B1; CNST; RPS7; RPS27A; REEP1; RPL31; RPL37A; RPL32; RPL15; RPSA; RPL14; RPL29; RPL24; RPL35A; NSG1; RPL9; RPL34; RPS3A; RPL37; RPS23; RPS14; GNB2L1; RPS18; RPS10; RPL10A; CD24; SEC63; RPS12; FIS1; RPS4X; RPL36A; RPL39; RPL10; RPS20; RPL7; RPL30; YWHAZ; RPL8; RPS6; SEC61B; RPL12; RPL7A; RPLP2; RPL27A; RPS13; TIMM10; BAD; RPS3; RPS25; RPS24; RPS26; RPL41; RPL6; RPLP0; RPL21; RPS29; CALM1; SRP14; RPL4; RPLP1; RPS17; RPS2; RPS15A; ARL6IP1; RPL13; YWHAE; VAMP2; RPL26; RPL23A; RPL23; RPL19; RPL27; RPL38; RAB31; RPL17; ROMO1; RPS21; RPS15; TIMM13; RPL36; RPS28; RPL18A; UBA52; NDUFA13; PDCD5; RPS16; RPS19; RPL18; RPL13A; RPS11; RPS9; RPL28; RPS5; RPL3
GO:0010257	NADH dehydrogenase complex assembly	2.99	1.15e-08	1.20e-06	28/60	NDUFS5; NDUFB3; NDUFAF3; NDUFB4; NDUFC1; NDUFS6; NDUFS4; NDUFA2; NDUFA5; NDUFA1; TMEM261; NDUFB6; NDUFB8; NDUFA12; NDUFB1; NDUFAB1; NDUFS7; NDUFA11; NDUFA7; NDUFB7; NDUFA13; NDUFA3; NDUFA6; MT-ND1; MT-ND2; MT-ND3; MT-ND4; MT-ND6
GO:2001023	regulation of response to drug	2.65	7.63e-04	2.15e-02	12/29	PARK7; SYT11; RGS2; AGT; NCOA1; SNCA; GNB2L1; TXN; SYT7; GAL; SNCG; ARL6IP1
GO:1902600	proton transmembrane transport	2.58	1.34e-07	9.82e-06	31/77	PARK7; COX7A2L; COX5B; ATP5G3; COX17; ATP5I; COX7C; ATP6V1G2; COX7A2; NDUFA4; ATP5J2; ATP6V1F; ATP6V0E2; TMSB4X; COX7B; COX6C; ATP6V1G1; COX8A; ATP5L; ATP5G2; COX6A1; ATP5G1; ATP5H; ATP5A1; CYB5A; ATP5E; NDUFS7; COX6B1; ATP5J; ATP5O; MT-ND4
GO:0033108	mitochondrial respiratory chain complex assembly	2.58	2.10e-08	1.93e-06	35/87	NDUFS5; COX20; NDUFB3; NDUFAF3; COX17; NDUFB4; NDUFC1; NDUFS6; NDUFS4; NDUFA2; NDUFA5; NDUFA1; TMEM261; NDUFB6; NDUFB8; COX14; NDUFA12; COX16; NDUFB1; NDUFAB1; COA3; NDUFS7; NDUFA11; PET100; NDUFA7; NDUFB7; NDUFA13; NDUFA3; UQCR10; NDUFA6; MT-ND1; MT-ND2; MT-ND3; MT-ND4; MT-ND6
GO:0006401	RNA catabolic process	2.55	0.00e+00	0.00e+00	94/236	RPL22; RPL11; RPS8; SERBP1; RPL5; RPS27; RPS7; RPS27A; RPL31; SSB; RPL37A; RPL32; LSM3; RPL15; RPSA; RPL14; PCBP4; RPL29; RPL24; RPL35A; RPL9; RPL34; LSM6; RPS3A; RPL37; RPS23; RPS14; NPM1; RPS18; RPS10; RPL10A; RPS12; LSM5; HSPB1; LINC01420; RPS4X; RPL36A; RPL39; RPL10; RPS20; RPL7; RPL30; PABPC1; YWHAZ; EIF3E; RPL8; RPS6; RPL12; RPL7A; RPLP2; RPL27A; RPS13; RPS3; RPS25; RPS24; RPS26; RPL41; CNOT2; RPL6; RPLP0; RPL21; RPS29; SLIRP; RPL4; RPLP1; RPS17; RPS2; RPS15A; RPL13; RPL26; RPL23A; RPL23; RPL19; RPL27; RPL38; EIF4A3; RPL17; RPS21; RPS15; RPL36; RPS28; C19orf43; RPL18A; LSM4; UBA52; RPS16; RPS19; RPL18; RPL13A; RPS11; RPS9; RPL28; RPS5; RPL3
GO:0006605	protein targeting	2.50	0.00e+00	0.00e+00	102/261	RPL22; RPL11; ATPIF1; HPCA; RPS8; RPL5; RPS27; TOMM20; RPS7; RPS27A; RPL31; RPL37A; RPL32; RPL15; RPSA; RPL14; RPL29; RPL24; RPL35A; RPL9; RPL34; RPS3A; RPL37; RPS23; RPS14; RPS18; RPS10; RPL10A; SEC63; RPS12; AKAP12; TOMM7; SEC61G; FIS1; SLC25A6; TIMM17B; RPS4X; RPL36A; RPL39; RPL10; RPS20; RPL7; RPL30; YWHAZ; RPL8; RPS6; SEC61B; RPL12; RPL7A; RPLP2; RPL27A; RPS13; IMMP1L; TIMM10; RPS3; TIMM8B; RPS25; RPS24; RPS26; RPL41; RPL6; RPLP0; RPL21; DNAJC15; AKAP6; RPS29; SRP14; RPL4; RPLP1; RPS17; RPS2; RPS15A; ARL6IP1; RPL13; RPL26; RPL23A; RPL23; RPL19; RPL27; RPL38; RPL17; ROMO1; RPS21; RPS15; TIMM13; RPL36; RPS28; UBL5; RPL18A; UBA52; HOMER3; NDUFA13; PDCD5; RPS16; RPS19; RPL18; RPL13A; RPS11; RPS9; RPL28; RPS5; RPL3
GO:0099132	ATP hydrolysis coupled cation transmembrane transport	2.40	2.11e-03	4.08e-02	12/32	ATP2B4; ATP5G3; ATP6V1F; ATP6V0E2; ATP5L; ATP5G2; ATP2B1; ATP5G1; ATP5H; ATP5A1; ATP5E; ATP5O
GO:0014074	response to purine-containing compound	2.30	1.51e-03	3.25e-02	14/39	SEPN1; RYR2; IGFBP5; NDUFS4; HDAC2; EZR; AKAP9; HSPA5; RAPGEF1; HSP90B1; PEBP1; AKAP6; NME1; BSG
GO:0032409	regulation of transporter activity	2.29	5.80e-06	3.04e-04	29/81	PARK7; SEPN1; HPCA; NOS1AP; ATP1B1; RYR2; FKBP1B; COX17; ATP1B3; SNCA; MEF2C; GLRX; ACTB; SRI; AKAP9; TMSB4X; GAL; FXYD6; KIF5B; KCNIP2; REM2; JPH4; AKAP6; CALM1; YWHAE; VAMP2; FKBP1A; FXYD7; HRC
GO:0010959	regulation of metal ion transport	2.26	8.88e-07	5.43e-05	35/99	SEPN1; NKAIN1; HPCA; NOS1AP; ATP1B1; ATP2B4; AGT; RYR2; FKBP1B; GNAI2; ATP1B3; SNCA; GLRX; TSPAN13; SRI; AKAP9; G6PD; CHD7; GAL; FXYD6; KIF5B; KCNIP2; CD63; REM2; JPH4; AKAP6; CALM1; YWHAE; VAMP2; FKBP1A; NKAIN4; HOMER3; FXYD7; HRC; ATF4
GO:0034765	regulation of ion transmembrane transport	2.13	1.19e-06	6.73e-05	39/117	PARK7; SEPN1; HPCA; NOS1AP; ATP1B1; RGS2; ATP2B4; AGT; RYR2; FKBP1B; SCN3A; SCN9A; COX17; ATP1B3; SNCA; MEF2C; GLRX; TSPAN13; SRI; AKAP9; TMSB4X; G6PD; CHD7; GAL; FXYD6; KIF5B; KCNIP2; CD63; REM2; JPH4; AKAP6; CALM1; ARL6IP1; YWHAE; VAMP2; FKBP1A; CACNA1A; FXYD7; HRC
GO:0034764	positive regulation of transmembrane transport	2.04	7.18e-04	2.11e-02	21/66	PARK7; NOS1AP; ATP1B1; AGT; RYR2; CAPN10; COX17; ATP1B3; SNCA; GLRX; SRI; AKAP9; TMSB4X; G6PD; GAL; KIF5B; KCNIP2; OSBPL8; AKAP6; CALM1; ARL6IP1
GO:0021953	central nervous system neuron differentiation	2.02	2.57e-03	4.71e-02	17/54	DRAXIN; LMO4; NRP2; MAP2; UQCRQ; ID4; SOX4; MDGA1; HSP90AB1; FZD1; MTPN; NFIB; C12orf57; MYCBP2; CBLN1; DCC; ADARB1

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SETD5 : 24 significant GO terms

GeneSet	description	enrichRatio	pValue	FDR	GeneRatio	geneSymbols
GO:0070972	protein localization to endoplasmic reticulum	9.76	0.00e+00	0.00e+00	81/119	RPL22; RPL11; RPS8; RPL5; RPS27; SRP9; RPS7; RPS27A; RPL31; RPL37A; RPL32; RPL15; RPSA; RPL14; RPL29; RPL24; RPL35A; RPL9; RPL34; RPS3A; RPL37; RPS23; RPS14; RPS18; RPS10; RPL10A; SEC63; RPS12; RPS4X; RPL36A; RPL39; RPL10; RPS20; RPL7; RPL30; RPL8; RPS6; RPL35; HSPA5; RPL12; RPL7A; RPLP2; RPL27A; RPS13; RPS3; RPS25; RPS24; RPL41; RPL6; RPLP0; RPL21; RPS29; RPL4; RPLP1; RPS17; RPS2; RPS15A; RPL13; RPL26; RPL23A; RPL23; RPL19; RPL27; RPL38; RPL17; RPS21; RPS15; RPL36; RPS28; RPL18A; UBA52; RPS16; RPS19; KDELR1; RPL18; RPL13A; RPS11; RPS9; RPL28; RPS5; RPL3
GO:0006413	translational initiation	8.04	0.00e+00	0.00e+00	88/157	RPL22; RPL11; RPS8; RPL5; RPS27; RPS7; RPS27A; RPL31; RPL37A; RPL32; RPL15; RPSA; RPL14; RPL29; RPL24; EIF4A2; RPL35A; RPL9; RPL34; RPS3A; RPL37; RPS23; RPS14; NPM1; RPS18; RPS10; RPL10A; RPS12; RPS4X; RPL36A; RPL39; RPL10; EIF4EBP1; RPS20; RPL7; RPL30; PABPC1; EIF3E; EIF3H; RPL8; RPS6; RPL35; RPL12; RPL7A; RPLP2; EIF3F; RPL27A; RPS13; EIF3M; RPS3; RPS25; RPS24; RPL41; RPL6; RPLP0; RPL21; RPS29; RPL4; RPLP1; RPS17; RPS2; RPS15A; RPL13; RPL26; RPL23A; RPL23; RPL19; RPL27; RPL38; RPL17; RPS21; RPS15; RPL36; RPS28; RPL18A; UBA52; EIF3K; RPS16; RPS19; RPL18; RPL13A; RPS11; RPS9; RPL28; RPS5; EIF3D; EIF3L; RPL3
GO:0002181	cytoplasmic translation	7.46	0.00e+00	0.00e+00	38/73	RPL11; RPL31; RPL32; RPL15; RPL29; RPL24; RPL35A; RPL9; RPS23; RPL10A; RPL36A; RPL39; EIF4EBP1; RPL30; EIF3E; EIF3H; RPL8; EIF3F; EIF3M; RPL41; RPL6; RPLP0; RPS29; RPLP1; RPL26; RPL19; RPL38; RPL17; RPS21; EEF2; RPL36; RPS28; RPL18A; EIF3K; RPL18; RPL13A; EIF3D; EIF3L
GO:0090150	establishment of protein localization to membrane	5.90	0.00e+00	0.00e+00	84/204	RPL22; RPL11; RPS8; RPL5; RPS27; SRP9; RPS7; RPS27A; RPL31; RPL37A; RPL32; RPL15; RPSA; RPL14; RPL29; RPL24; RPL35A; RPL9; RPL34; RPS3A; RPL37; RPS23; RPS14; GNB2L1; RPS18; RPS10; RPL10A; SEC63; RPS12; RPS4X; RPL36A; RPL39; RPL10; RPS20; RPL7; RPL30; RPL8; RPS6; RPL35; RPL12; RPL7A; RPLP2; RPL27A; RPS13; TIMM10; BAD; RPS3; RPS25; RPS24; RPL41; RPL6; RPLP0; RPL21; RPS29; RPL4; RPLP1; RPS17; RPS2; RPS15A; RPL13; VAMP2; RPL26; RPL23A; RPL23; RPL19; RPL27; RPL38; RPL17; RPS21; RPS15; TIMM13; RPL36; RPS28; RPL18A; UBA52; RPS16; RPS19; RPL18; RPL13A; RPS11; RPS9; RPL28; RPS5; RPL3
GO:0006401	RNA catabolic process	5.53	0.00e+00	0.00e+00	91/236	RPL22; RPL11; YBX1; RPS8; SERBP1; RPL5; RPS27; RPS7; RPS27A; RPL31; SSB; RPL37A; RPL32; RPL15; RPSA; RPL14; PCBP4; RPL29; RPL24; RPL35A; RPL9; RPL34; RPS3A; RPL37; RPS23; RPS14; NPM1; RPS18; RPS10; RPL10A; RPS12; RPS4X; RPL36A; RPL39; RPL10; RPS20; RPL7; RPL30; PABPC1; EIF3E; RPL8; RPS6; RPL35; RPL12; RPL7A; RPLP2; RPL27A; RPS13; RPS3; RPS25; RPS24; RPL41; RPL6; RPLP0; UBC; RPL21; HNRNPC; RPS29; RPL4; RPLP1; RPS17; RPS2; RPS15A; RPL13; RPL26; RPL23A; RPL23; RPL19; RPL27; DDX5; RPL38; RPL17; RPS21; CIRBP; RPS15; LSM7; RPL36; RPS28; C19orf43; RPL18A; LSM4; UBA52; RPS16; RPS19; RPL18; RPL13A; RPS11; RPS9; RPL28; RPS5; RPL3
GO:0006605	protein targeting	4.72	0.00e+00	0.00e+00	86/261	RPL22; RPL11; RPS8; RPL5; RPS27; SRP9; TOMM20; RPS7; RPS27A; RPL31; HSPD1; RPL37A; RPL32; RPL15; RPSA; RPL14; RPL29; RPL24; RPL35A; RPL9; RPL34; RPS3A; RPL37; RPS23; RPS14; RPS18; RPS10; RPL10A; SEC63; RPS12; SLC25A6; RPS4X; RPL36A; RPL39; RPL10; RPS20; RPL7; RPL30; RPL8; RPS6; RPL35; RPL12; RPL7A; RPLP2; RPL27A; RPS13; TIMM10; RPS3; TIMM8B; RPS25; RPS24; RPL41; RPL6; RPLP0; UBC; RPL21; RPS29; RPL4; RPLP1; RPS17; RPS2; RPS15A; RPL13; RPL26; RPL23A; RPL23; RPL19; RPL27; RPL38; RPL17; RPS21; RPS15; TIMM13; RPL36; RPS28; RPL18A; UBA52; RPS16; RPS19; RPL18; RPL13A; RPS11; RPS9; RPL28; RPS5; RPL3
GO:0046683	response to organophosphorus	4.22	6.90e-05	3.38e-03	10/34	JUN; HSPD1; NDUFS4; EZR; HSPA5; LDHA; HSP90B1; NME1; BSG; SOD1
GO:0006959	humoral immune response	4.18	9.26e-04	2.83e-02	7/24	HMGN2; RBPJ; RPL39; RPL30; GAPDH; C1QBP; RPS19
GO:0001906	cell killing	4.10	4.65e-04	1.48e-02	8/28	HMGN2; PRDX1; HSP90AB1; RPL30; BAD; GAPDH; VAMP2; RPS19
GO:0014074	response to purine-containing compound	3.68	2.44e-04	8.96e-03	10/39	JUN; HSPD1; NDUFS4; EZR; HSPA5; LDHA; HSP90B1; NME1; BSG; SOD1
GO:0032355	response to estradiol	3.23	1.39e-03	4.04e-02	9/40	AGT; IGFBP2; H2AFZ; CASP3; BAD; GSTP1; SSTR2; EEF2; CALR
GO:0006090	pyruvate metabolic process	3.22	4.24e-04	1.43e-02	11/49	ENO1; SLC16A1; VDAC1; LDHA; PGAM1; GAPDH; TPI1; LDHB; PKM; ALDOA; BSG
GO:0035821	modification of morphology or physiology of other organism	2.99	1.43e-03	4.04e-02	10/48	HMGN2; JUN; NUCKS1; SLC25A6; RPL30; BAD; CFL1; GAPDH; PPIB; RPS19
GO:1902600	proton transmembrane transport	2.98	5.95e-05	3.12e-03	16/77	PARK7; COX7A2L; ATP5G3; COX7C; ATP6V1G2; NDUFA4; COX7B; COX8A; COX6A1; COX5A; ATP5G1; ATP5A1; ATP5D; COX6B1; MT-ND4; MT-CYB
GO:0071826	ribonucleoprotein complex subunit organization	2.79	8.49e-09	7.79e-07	36/185	RPL11; RPL5; RPS27; RPSA; RPL24; RPS23; RPS14; NPM1; RPS10; HSP90AB1; RBMX; RPL10; EIF3E; EIF3H; RPL12; EIF3F; EIF3M; SNRPF; RPL6; RPLP0; C1QBP; RPL23A; RPL38; SNRPD1; CIRBP; RPS15; RPS28; LSM4; EIF3K; RPS19; GLTSCR2; RPL13A; RPS5; EIF3D; EIF3L; RPL3
GO:0016072	rRNA metabolic process	2.68	1.58e-07	1.29e-05	32/171	RPL11; RPS8; RPL5; RPS27; RPS7; NCL; RPSA; RPL14; RPL35A; RPS14; NHP2; RPL10A; RPL7; RPS6; RPL35; RPL7A; DDX21; RPS24; PA2G4; GTF3A; RPS17; RPS2; RPL26; RPL27; RPS21; RPS15; RPS28; C19orf43; RPS16; RPS19; GLTSCR2; RPS9
GO:0022613	ribonucleoprotein complex biogenesis	2.52	1.10e-11	1.15e-09	58/330	RPL11; RPS8; RPL5; RPS27; RPS7; RPSA; RPL14; RPL24; RPL35A; RPS23; RPS14; NPM1; NHP2; RPS10; RPL10A; HSP90AB1; RBMX; RPL10; RPL7; EIF3E; EIF3H; RPS6; RPL35; RPL12; RPL7A; EIF3F; EIF3M; DDX21; RPS24; PA2G4; SNRPF; RPL6; RPLP0; RAN; GTF3A; RPS17; RPS2; C1QBP; RPL26; RPL23A; RPL27; RPL38; SNRPD1; RPS21; CIRBP; RPS15; RPS28; LSM4; EIF3K; RPS16; RPS19; GLTSCR2; RPL13A; RPS9; RPS5; EIF3D; EIF3L; RPL3
GO:0009141	nucleoside triphosphate metabolic process	2.50	5.44e-07	3.99e-05	33/189	PARK7; ENO1; UQCRH; COX7A2L; ATP5G3; IMPDH2; NDUFS4; COX7C; NDUFA4; CYCS; NDUFB2; NDUFA1; LDHA; BAD; PGAM1; GAPDH; TPI1; COX6A1; RAN; PKM; COX5A; NME4; NDUFB10; ALDOA; DCTPP1; ATP5G1; NME1; ATP5A1; ATP5D; MT-ND2; MT-ND3; MT-ND4; MT-CYB
GO:0046677	response to antibiotic	2.49	7.45e-05	3.42e-03	21/121	PARK7; JUN; FKBP1B; HSPD1; EEF1B2; CASP3; GNB2L1; NEFL; TNC; HSPA5; LDHA; BAD; GSTP1; RPS3; HNRNPA1; RPL23; PYCR1; EEF2; SOD1; MT-ND4; MT-CYB
GO:0009123	nucleoside monophosphate metabolic process	2.28	9.40e-06	5.75e-04	31/195	PARK7; ENO1; UQCRH; COX7A2L; ATP5G3; IMPDH2; PAICS; NDUFS4; COX7C; HDDC2; NDUFA4; CYCS; NDUFB2; NDUFA1; LDHA; BAD; PGAM1; GAPDH; TPI1; COX6A1; PKM; COX5A; NDUFB10; ALDOA; ATP5G1; ATP5A1; ATP5D; MT-ND2; MT-ND3; MT-ND4; MT-CYB
GO:0009636	response to toxic substance	2.21	8.96e-05	3.65e-03	26/169	PARK7; PRDX1; JUN; FKBP1B; SCN9A; HSPD1; EEF1B2; CASP3; GNB2L1; PRDX4; NEFL; TNC; LDHA; BAD; GSTP1; RPS3; RGS10; HNRNPA1; ESD; PYCR1; EEF2; PRDX2; UBA52; SOD1; MT-ND4; MT-CYB
GO:0010608	posttranscriptional regulation of gene expression	2.11	1.95e-06	1.30e-04	42/286	YBX1; SERBP1; RPL5; SRP9; H3F3A; RPS27A; NCL; PCBP4; EIF4A2; RPS14; NPM1; GNB2L1; SOX4; HNRNPA2B1; RBM3; RPS4X; RPL10; EIF4EBP1; POLR2K; PABPC1; EIF3E; EIF3H; RPS3; GAPDH; PA2G4; UBC; RAN; HNRNPC; C1QBP; EIF5A; RPL26; DDX5; RPL38; CIRBP; EEF2; CALR; UBA52; POLR2I; EIF3K; RPL13A; RPS9; EIF3D
GO:0034248	regulation of cellular amide metabolic process	2.02	8.05e-05	3.48e-03	32/227	RPL5; SRP9; NCL; EIF4A2; CASP3; RPS14; NPM1; GNB2L1; SOX4; EEF1A1; RBM3; RPS4X; RPL10; EIF4EBP1; PABPC1; EIF3E; EIF3H; RPS3; PGAM1; GAPDH; PA2G4; C1QBP; EIF5A; RPL26; RPL38; CIRBP; EEF2; CALR; EIF3K; RPL13A; RPS9; EIF3D
GO:0009259	ribonucleotide metabolic process	2.01	3.25e-05	1.83e-03	36/257	PARK7; ENO1; UQCRH; COX7A2L; ATP5G3; IMPDH2; PAICS; NDUFS4; COX7C; HINT1; ELOVL4; NDUFA4; CYCS; NDUFB2; NDUFA1; LDHA; BAD; PGAM1; SCD; GAPDH; TPI1; COX6A1; RAN; PKM; COX5A; NME4; NDUFB10; ALDOA; ATP5G1; NME1; ATP5A1; ATP5D; MT-ND2; MT-ND3; MT-ND4; MT-CYB

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Summary:

Marker	ADNP	ARID1B	ASH1L	CHD2	DYRK1A	PTEN	SETD5
Signif_GO_terms	25	20	33	21	2	22	24

6.2 Reactome Pathway Over-Representation Analysis

Gene sets: The Reactome pathway database.

ADNP : 137 significant Reactome pathways

GeneSet	description	enrichRatio	pValue	FDR	GeneRatio	geneSymbols
R-HSA-156902	Peptide chain elongation	4.71	0.00e+00	0.00e+00	56/84	RPL22; RPL11; RPS8; RPL5; RPS27A; RPL31; RPL37A; RPL32; RPL15; RPSA; RPL14; RPL35A; RPL9; RPL34; RPS3A; RPS23; RPS14; RPS10; EEF1A1; RPS12; RPS4X; RPL36A; RPL10; RPL7; RPL30; RPS6; RPL35; RPL7A; RPL27A; RPS13; RPS24; RPS26; RPL41; RPL6; RPLP0; RPL21; RPS29; RPL4; RPLP1; RPS17; RPS2; RPS15A; RPL13; RPL26; RPL23A; RPL19; RPL27; RPS15; RPS28; RPL18A; RPS16; RPS19; RPL18; RPL13A; RPS5; RPL3
R-HSA-156842	Eukaryotic Translation Elongation	4.68	0.00e+00	0.00e+00	57/86	RPL22; RPL11; RPS8; RPL5; RPS27A; RPL31; EEF1B2; RPL37A; RPL32; RPL15; RPSA; RPL14; RPL35A; RPL9; RPL34; RPS3A; RPS23; RPS14; RPS10; EEF1A1; RPS12; RPS4X; RPL36A; RPL10; RPL7; RPL30; RPS6; RPL35; RPL7A; RPL27A; RPS13; RPS24; RPS26; RPL41; RPL6; RPLP0; RPL21; RPS29; RPL4; RPLP1; RPS17; RPS2; RPS15A; RPL13; RPL26; RPL23A; RPL19; RPL27; RPS15; RPS28; RPL18A; RPS16; RPS19; RPL18; RPL13A; RPS5; RPL3
R-HSA-192823	Viral mRNA Translation	4.68	0.00e+00	0.00e+00	55/83	RPL22; RPL11; RPS8; RPL5; RPS27A; RPL31; RPL37A; RPL32; RPL15; RPSA; RPL14; RPL35A; RPL9; RPL34; RPS3A; RPS23; RPS14; RPS10; RPS12; RPS4X; RPL36A; RPL10; RPL7; RPL30; RPS6; RPL35; RPL7A; RPL27A; RPS13; RPS24; RPS26; RPL41; RPL6; RPLP0; RPL21; RPS29; RPL4; RPLP1; RPS17; RPS2; RPS15A; RPL13; RPL26; RPL23A; RPL19; RPL27; RPS15; RPS28; RPL18A; RPS16; RPS19; RPL18; RPL13A; RPS5; RPL3
R-HSA-2408557	Selenocysteine synthesis	4.57	0.00e+00	0.00e+00	55/85	RPL22; RPL11; RPS8; RPL5; RPS27A; RPL31; RPL37A; RPL32; RPL15; RPSA; RPL14; RPL35A; RPL9; RPL34; RPS3A; RPS23; RPS14; RPS10; RPS12; RPS4X; RPL36A; RPL10; RPL7; RPL30; RPS6; RPL35; RPL7A; RPL27A; RPS13; RPS24; RPS26; RPL41; RPL6; RPLP0; RPL21; RPS29; RPL4; RPLP1; RPS17; RPS2; RPS15A; RPL13; RPL26; RPL23A; RPL19; RPL27; RPS15; RPS28; RPL18A; RPS16; RPS19; RPL18; RPL13A; RPS5; RPL3
R-HSA-445355	Smooth Muscle Contraction	4.57	2.28e-06	5.45e-05	11/17	TPM3; ANXA6; CALD1; TPM2; VCL; MYL6B; MYL6; MYL12A; MYL12B; TPM4; CALM3
R-HSA-72764	Eukaryotic Translation Termination	4.52	0.00e+00	0.00e+00	55/86	RPL22; RPL11; RPS8; RPL5; RPS27A; RPL31; RPL37A; RPL32; RPL15; RPSA; RPL14; RPL35A; RPL9; RPL34; RPS3A; RPS23; RPS14; RPS10; RPS12; RPS4X; RPL36A; RPL10; RPL7; RPL30; RPS6; RPL35; RPL7A; RPL27A; RPS13; RPS24; RPS26; RPL41; RPL6; RPLP0; RPL21; RPS29; RPL4; RPLP1; RPS17; RPS2; RPS15A; RPL13; RPL26; RPL23A; RPL19; RPL27; RPS15; RPS28; RPL18A; RPS16; RPS19; RPL18; RPL13A; RPS5; RPL3
R-HSA-975956	Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)	4.41	0.00e+00	0.00e+00	55/88	RPL22; RPL11; RPS8; RPL5; RPS27A; RPL31; RPL37A; RPL32; RPL15; RPSA; RPL14; RPL35A; RPL9; RPL34; RPS3A; RPS23; RPS14; RPS10; RPS12; RPS4X; RPL36A; RPL10; RPL7; RPL30; RPS6; RPL35; RPL7A; RPL27A; RPS13; RPS24; RPS26; RPL41; RPL6; RPLP0; RPL21; RPS29; RPL4; RPLP1; RPS17; RPS2; RPS15A; RPL13; RPL26; RPL23A; RPL19; RPL27; RPS15; RPS28; RPL18A; RPS16; RPS19; RPL18; RPL13A; RPS5; RPL3
R-HSA-389960	Formation of tubulin folding intermediates by CCT/TriC	4.41	1.07e-05	2.42e-04	10/16	CCT7; TUBA4A; CCT5; TUBB2A; TCP1; TUBB4B; TUBA1B; TUBA1A; TUBB3; TUBB4A
R-HSA-1799339	SRP-dependent cotranslational protein targeting to membrane	4.14	0.00e+00	0.00e+00	61/104	RPL22; DDOST; RPL11; RPS8; RPL5; RPS27A; RPL31; RPL37A; RPL32; RPL15; RPSA; RPL14; RPL35A; RPL9; RPL34; RPS3A; RPS23; RPS14; RPS10; RPS12; RPS4X; RPL36A; SSR4; RPL10; RPL7; RPL30; RPS6; RPL35; RPL7A; RPL27A; RPS13; SPCS2; RPS24; RPS26; RPL41; RPL6; RPLP0; RPL21; RPS29; SRP14; RPL4; RPLP1; RPS17; RPS2; RPS15A; RPL13; RPL26; RPL23A; RPL19; RPL27; SEC11C; RPN2; RPS15; RPS28; RPL18A; RPS16; RPS19; RPL18; RPL13A; RPS5; RPL3
R-HSA-72689	Formation of a pool of free 40S subunits	4.09	0.00e+00	0.00e+00	55/95	RPL22; RPL11; RPS8; RPL5; RPS27A; RPL31; RPL37A; RPL32; RPL15; RPSA; RPL14; RPL35A; RPL9; RPL34; RPS3A; RPS23; RPS14; RPS10; RPS12; RPS4X; RPL36A; RPL10; RPL7; RPL30; RPS6; RPL35; RPL7A; RPL27A; RPS13; RPS24; RPS26; RPL41; RPL6; RPLP0; RPL21; RPS29; RPL4; RPLP1; RPS17; RPS2; RPS15A; RPL13; RPL26; RPL23A; RPL19; RPL27; RPS15; RPS28; RPL18A; RPS16; RPS19; RPL18; RPL13A; RPS5; RPL3
R-HSA-8955332	Carboxyterminal post-translational modifications of tubulin	4.04	2.09e-04	3.27e-03	8/14	TUBA4A; TUBB2A; TUBB4B; TUBA1B; TUBA1A; TUBB3; TPGS2; TUBB4A
R-HSA-2408522	Selenoamino acid metabolism	3.92	0.00e+00	0.00e+00	55/99	RPL22; RPL11; RPS8; RPL5; RPS27A; RPL31; RPL37A; RPL32; RPL15; RPSA; RPL14; RPL35A; RPL9; RPL34; RPS3A; RPS23; RPS14; RPS10; RPS12; RPS4X; RPL36A; RPL10; RPL7; RPL30; RPS6; RPL35; RPL7A; RPL27A; RPS13; RPS24; RPS26; RPL41; RPL6; RPLP0; RPL21; RPS29; RPL4; RPLP1; RPS17; RPS2; RPS15A; RPL13; RPL26; RPL23A; RPL19; RPL27; RPS15; RPS28; RPL18A; RPS16; RPS19; RPL18; RPL13A; RPS5; RPL3
R-HSA-190828	Gap junction trafficking	3.92	4.45e-05	8.34e-04	10/18	TUBA4A; TUBB2A; CLTA; DNM1; TUBB4B; TUBA1B; TUBA1A; TUBB3; ACTG1; TUBB4A
R-HSA-5626467	RHO GTPases activate IQGAPs	3.92	4.45e-05	8.34e-04	10/18	CDC42; TUBA4A; TUBB2A; TUBB4B; TUBA1B; TUBA1A; TUBB3; ACTG1; TUBB4A; CALM3
R-HSA-373076	Class A/1 (Rhodopsin-like receptors)	3.85	1.92e-03	1.41e-02	6/11	AGT; SST; GAL; PSAP; NMB; SSTR2
R-HSA-983170	Antigen Presentation: Folding, assembly and peptide loading of class I MHC	3.85	1.92e-03	1.41e-02	6/11	HLA-A; BCAP31; HSPA5; PDIA3; B2M; CALR
R-HSA-927802	Nonsense-Mediated Decay (NMD)	3.83	0.00e+00	0.00e+00	57/105	RPL22; RPL11; RPS8; RPL5; RPS27A; RPL31; RPL37A; RPL32; RPL15; RPSA; RPL14; RPL35A; RPL9; RPL34; RPS3A; RPS23; RPS14; RPS10; RPS12; RPS4X; RPL36A; RPL10; RPL7; RPL30; RPS6; RPL35; RPL7A; RPL27A; RPS13; RPS24; MAGOHB; RPS26; RPL41; RPL6; RPLP0; RPL21; RPS29; RPL4; RPLP1; RPS17; RPS2; RPS15A; RPL13; RPL26; RPL23A; RPL19; RPL27; EIF4A3; RPS15; RPS28; RPL18A; RPS16; RPS19; RPL18; RPL13A; RPS5; RPL3
R-HSA-975957	Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)	3.83	0.00e+00	0.00e+00	57/105	RPL22; RPL11; RPS8; RPL5; RPS27A; RPL31; RPL37A; RPL32; RPL15; RPSA; RPL14; RPL35A; RPL9; RPL34; RPS3A; RPS23; RPS14; RPS10; RPS12; RPS4X; RPL36A; RPL10; RPL7; RPL30; RPS6; RPL35; RPL7A; RPL27A; RPS13; RPS24; MAGOHB; RPS26; RPL41; RPL6; RPLP0; RPL21; RPS29; RPL4; RPLP1; RPS17; RPS2; RPS15A; RPL13; RPL26; RPL23A; RPL19; RPL27; EIF4A3; RPS15; RPS28; RPL18A; RPS16; RPS19; RPL18; RPL13A; RPS5; RPL3
R-HSA-389977	Post-chaperonin tubulin folding pathway	3.80	8.65e-04	8.37e-03	7/13	TUBA4A; TUBB2A; TUBB4B; TUBA1B; TUBA1A; TUBB3; TUBB4A
R-HSA-156827	L13a-mediated translational silencing of Ceruloplasmin expression	3.77	0.00e+00	0.00e+00	56/105	RPL22; RPL11; RPS8; RPL5; RPS27A; RPL31; RPL37A; RPL32; RPL15; RPSA; RPL14; RPL35A; RPL9; RPL34; RPS3A; RPS23; RPS14; RPS10; RPS12; RPS4X; RPL36A; RPL10; RPL7; RPL30; RPS6; RPL35; RPL7A; RPL27A; RPS13; RPS24; RPS26; RPL41; RPL6; RPLP0; RPL21; RPS29; RPL4; RPLP1; RPS17; RPS2; RPS15A; RPL13; RPL26; RPL23A; RPL19; RPL27; EIF2S2; RPS15; RPS28; RPL18A; RPS16; RPS19; RPL18; RPL13A; RPS5; RPL3
R-HSA-72706	GTP hydrolysis and joining of the 60S ribosomal subunit	3.73	0.00e+00	0.00e+00	56/106	RPL22; RPL11; RPS8; RPL5; RPS27A; RPL31; RPL37A; RPL32; RPL15; RPSA; RPL14; RPL35A; RPL9; RPL34; RPS3A; RPS23; RPS14; RPS10; RPS12; RPS4X; RPL36A; RPL10; RPL7; RPL30; RPS6; RPL35; RPL7A; RPL27A; RPS13; RPS24; RPS26; RPL41; RPL6; RPLP0; RPL21; RPS29; RPL4; RPLP1; RPS17; RPS2; RPS15A; RPL13; RPL26; RPL23A; RPL19; RPL27; EIF2S2; RPS15; RPS28; RPL18A; RPS16; RPS19; RPL18; RPL13A; RPS5; RPL3
R-HSA-157858	Gap junction trafficking and regulation	3.72	8.23e-05	1.51e-03	10/19	TUBA4A; TUBB2A; CLTA; DNM1; TUBB4B; TUBA1B; TUBA1A; TUBB3; ACTG1; TUBB4A
R-HSA-72613	Eukaryotic Translation Initiation	3.56	0.00e+00	0.00e+00	57/113	RPL22; RPL11; RPS8; RPL5; RPS27A; RPL31; RPL37A; RPL32; RPL15; RPSA; RPL14; RPL35A; RPL9; RPL34; RPS3A; RPS23; RPS14; RPS10; RPS12; RPS4X; RPL36A; RPL10; EIF4EBP1; RPL7; RPL30; RPS6; RPL35; RPL7A; RPL27A; RPS13; RPS24; RPS26; RPL41; RPL6; RPLP0; RPL21; RPS29; RPL4; RPLP1; RPS17; RPS2; RPS15A; RPL13; RPL26; RPL23A; RPL19; RPL27; EIF2S2; RPS15; RPS28; RPL18A; RPS16; RPS19; RPL18; RPL13A; RPS5; RPL3
R-HSA-72737	Cap-dependent Translation Initiation	3.56	0.00e+00	0.00e+00	57/113	RPL22; RPL11; RPS8; RPL5; RPS27A; RPL31; RPL37A; RPL32; RPL15; RPSA; RPL14; RPL35A; RPL9; RPL34; RPS3A; RPS23; RPS14; RPS10; RPS12; RPS4X; RPL36A; RPL10; EIF4EBP1; RPL7; RPL30; RPS6; RPL35; RPL7A; RPL27A; RPS13; RPS24; RPS26; RPL41; RPL6; RPLP0; RPL21; RPS29; RPL4; RPLP1; RPS17; RPS2; RPS15A; RPL13; RPL26; RPL23A; RPL19; RPL27; EIF2S2; RPS15; RPS28; RPL18A; RPS16; RPS19; RPL18; RPL13A; RPS5; RPL3
R-HSA-156590	Glutathione conjugation	3.53	3.38e-03	2.08e-02	6/12	GSTM3; MGST3; MGST2; GGCT; GSTP1; ESD
R-HSA-888590	GABA synthesis, release, reuptake and degradation	3.53	7.60e-03	3.96e-02	5/10	CPLX1; STX1A; HSPA8; SNAP25; RAB3A
R-HSA-5663084	Diseases of carbohydrate metabolism	3.53	7.60e-03	3.96e-02	5/10	RPS27A; TALDO1; UBC; G6PC3; DCXR
R-HSA-390522	Striated Muscle Contraction	3.53	7.60e-03	3.96e-02	5/10	TPM3; TPM2; ACTC1; TNNC2; TPM4
R-HSA-168273	Influenza Viral RNA Transcription and Replication	3.50	0.00e+00	0.00e+00	56/113	RPL22; RPL11; RPS8; RPL5; RPS27A; RPL31; RPL37A; RPL32; RPL15; RPSA; RPL14; RPL35A; RPL9; RPL34; RPS3A; RPS23; RPS14; RPS10; RPS12; RPS4X; RPL36A; RPL10; RPL7; RPL30; RPS6; RPL35; RPL7A; RPL27A; RPS13; RPS24; RPS26; RPL41; RPL6; RPLP0; RPL21; RPS29; HSP90AA1; RPL4; RPLP1; RPS17; RPS2; RPS15A; RPL13; RPL26; RPL23A; RPL19; RPL27; RPS15; RPS28; RPL18A; RPS16; RPS19; RPL18; RPL13A; RPS5; RPL3
R-HSA-9010553	Regulation of expression of SLITs and ROBOs	3.46	0.00e+00	0.00e+00	73/149	RPL22; RPL11; RPS8; RPL5; PSMA5; PSMD4; RPS27A; RPL31; RPL37A; RPL32; RPL15; RPSA; RPL14; PSMD6; ROBO1; RPL35A; RPL9; RPL34; RPS3A; RPS23; RPS14; RPS10; RPS12; PSMB1; PSMC2; RPS4X; RPL36A; RPL10; RPL7; TCEB1; RPL30; RPS6; RPL35; RPL7A; PSMD13; RPL27A; RPS13; RPS24; MAGOHB; RPS26; RPL41; RPL6; RPLP0; UBC; RPL21; PSME2; RPS29; PSMA3; RPL4; RPLP1; PSMA4; RPS17; RPS2; RPS15A; PSMD7; RPL13; RPL26; RPL23A; PSMB3; RPL19; RPL27; PSMC5; EIF4A3; PSMA7; RPS15; RPS28; RPL18A; RPS16; RPS19; RPL18; RPL13A; RPS5; RPL3
R-HSA-500792	GPCR ligand binding	3.40	2.36e-05	4.96e-04	13/27	GNG5; AGT; GNG4; SST; GRM4; FZD1; GABBR2; GAL; PSAP; NMB; SSTR2; GNG8; PTH2
R-HSA-168255	Influenza Life Cycle	3.39	0.00e+00	0.00e+00	58/121	RPL22; RPL11; RPS8; RPL5; RPS27A; RPL31; RPL37A; RPL32; RPL15; RPSA; RPL14; RPL35A; RPL9; RPL34; RPS3A; RPS23; RPS14; RPS10; RPS12; RPS4X; RPL36A; RPL10; RPL7; RPL30; RPS6; CLTA; RPL35; RPL7A; RPL27A; RPS13; RPS24; RPS26; RPL41; RPL6; RPLP0; RPL21; RPS29; HSP90AA1; RPL4; RPLP1; RPS17; RPS2; RPS15A; RPL13; RPL26; RPL23A; RPL19; RPL27; RPS15; RPS28; CALR; RPL18A; RPS16; RPS19; RPL18; RPL13A; RPS5; RPL3
R-HSA-72695	Formation of the ternary complex, and subsequently, the 43S complex	3.38	1.80e-08	5.17e-07	23/48	RPS8; RPS27A; RPSA; RPS3A; RPS23; RPS14; RPS10; RPS12; RPS4X; RPS6; RPS13; RPS24; RPS26; RPS29; RPS17; RPS2; RPS15A; EIF2S2; RPS15; RPS28; RPS16; RPS19; RPS5
R-HSA-389958	Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding	3.38	1.11e-04	1.99e-03	11/23	CCT7; TUBA4A; CCT5; TUBB2A; TCP1; TUBB4B; TUBA1B; TUBA1A; PFDN5; TUBB3; TUBB4A
R-HSA-70263	Gluconeogenesis	3.35	5.23e-04	6.17e-03	9/19	ENO1; MDH1; MDH2; PGK1; PGAM1; TPI1; ALDOA; ENO3; G6PC3
R-HSA-397014	Muscle contraction	3.34	2.96e-09	9.11e-08	26/55	TPM3; ATP1B1; RYR2; SCN3A; ATP1B3; CAMK2D; ANXA6; CAMK2B; SRI; AKAP9; CALD1; TPM2; FXYD6; VCL; KCNIP2; CACNB3; MYL6B; MYL6; ACTC1; MYL12A; MYL12B; TNNC2; TPM4; FXYD1; FXYD7; CALM3
R-HSA-168254	Influenza Infection	3.31	0.00e+00	0.00e+00	60/128	RPL22; RPL11; RPS8; RPL5; RPS27A; RPL31; RPL37A; RPL32; RPL15; RPSA; RPL14; RPL35A; RPL9; RPL34; RPS3A; RPS23; RPS14; RPS10; RPS12; SLC25A6; RPS4X; RPL36A; RPL10; RPL7; RPL30; RPS6; CLTA; RPL35; RPL7A; RPL27A; RPS13; RPS24; RPS26; RPL41; RPL6; RPLP0; RPL21; RPS29; HSP90AA1; RPL4; RPLP1; RPS17; RPS2; RPS15A; RPL13; RPL26; RPL23A; RPL19; RPL27; KPNA2; RPS15; RPS28; CALR; RPL18A; RPS16; RPS19; RPL18; RPL13A; RPS5; RPL3
R-HSA-389957	Prefoldin mediated transfer of substrate to CCT/TriC	3.21	3.86e-04	5.19e-03	10/22	CCT7; TUBA4A; CCT5; TUBB2A; TCP1; TUBB4B; TUBA1A; PFDN5; TUBB3; TUBB4A
R-HSA-5578775	Ion homeostasis	3.07	5.97e-04	6.51e-03	10/23	ATP1B1; RYR2; ATP1B3; CAMK2D; CAMK2B; SRI; FXYD6; FXYD1; FXYD7; CALM3
R-HSA-376176	Signaling by ROBO receptors	3.06	0.00e+00	0.00e+00	77/178	RPL22; CDC42; RPL11; RPS8; RPL5; PSMA5; PSMD4; RPS27A; RPL31; RPL37A; SRGAP3; RPL32; RPL15; RPSA; RPL14; PSMD6; ROBO1; RPL35A; RPL9; RPL34; RPS3A; RPS23; RPS14; CAP2; RPS10; RPS12; PSMB1; PSMC2; RPS4X; RPL36A; RPL10; RPL7; TCEB1; RPL30; RPS6; RPL35; RPL7A; PSMD13; RPL27A; RPS13; RPS24; MAGOHB; RPS26; RPL41; SRGAP1; RPL6; RPLP0; UBC; RPL21; PSME2; RPS29; PSMA3; RPL4; RPLP1; PSMA4; RPS17; RPS2; RPS15A; PSMD7; RPL13; RPL26; RPL23A; PSMB3; RPL19; RPL27; PSMC5; EIF4A3; PSMA7; RPS15; RPS28; RPL18A; RPS16; RPS19; RPL18; RPL13A; RPS5; RPL3
R-HSA-72662	Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S	3.03	1.30e-07	3.49e-06	24/56	RPS8; RPS27A; RPSA; RPS3A; RPS23; RPS14; RPS10; RPS12; RPS4X; EIF4EBP1; RPS6; RPS13; RPS24; RPS26; RPS29; RPS17; RPS2; RPS15A; EIF2S2; RPS15; RPS28; RPS16; RPS19; RPS5
R-HSA-8852276	The role of GTSE1 in G2/M progression after G2 checkpoint	2.95	4.10e-07	1.01e-05	23/55	PSMA5; PSMD4; RPS27A; TUBA4A; PSMD6; TUBB2A; PSMB1; PSMC2; TUBB4B; PSMD13; TUBA1B; TUBA1A; UBC; PSME2; PSMA3; HSP90AA1; PSMA4; PSMD7; TUBB3; PSMB3; PSMC5; PSMA7; TUBB4A
R-HSA-72649	Translation initiation complex formation	2.95	4.10e-07	1.01e-05	23/55	RPS8; RPS27A; RPSA; RPS3A; RPS23; RPS14; RPS10; RPS12; RPS4X; RPS6; RPS13; RPS24; RPS26; RPS29; RPS17; RPS2; RPS15A; EIF2S2; RPS15; RPS28; RPS16; RPS19; RPS5
R-HSA-72702	Ribosomal scanning and start codon recognition	2.95	4.10e-07	1.01e-05	23/55	RPS8; RPS27A; RPSA; RPS3A; RPS23; RPS14; RPS10; RPS12; RPS4X; RPS6; RPS13; RPS24; RPS26; RPS29; RPS17; RPS2; RPS15A; EIF2S2; RPS15; RPS28; RPS16; RPS19; RPS5
R-HSA-437239	Recycling pathway of L1	2.92	2.97e-04	4.26e-03	12/29	TUBA4A; TUBB2A; EZR; DPYSL2; CLTA; DNM1; TUBB4B; TUBA1B; TUBA1A; TUBB3; ACTG1; TUBB4A
R-HSA-977225	Amyloid fiber formation	2.88	6.23e-04	6.71e-03	11/27	H3F3A; RPS27A; SNCA; HIST1H4C; HIST1H2AC; UBE2L6; UBC; ITM2B; B2M; CST3; PSENEN
R-HSA-5576891	Cardiac conduction	2.83	1.44e-04	2.43e-03	14/35	ATP1B1; RYR2; SCN3A; ATP1B3; CAMK2D; CAMK2B; SRI; AKAP9; FXYD6; KCNIP2; CACNB3; FXYD1; FXYD7; CALM3
R-HSA-114608	Platelet degranulation	2.79	3.34e-05	6.54e-04	17/43	TAGLN2; TUBA4A; MANF; WDR1; SPARC; PPIA; MAGED2; HSPA5; APLP2; PSAP; VCL; CD63; SCG3; ALDOA; LGALS3BP; CALM3; SOD1
R-HSA-76005	Response to elevated platelet cytosolic Ca2+	2.79	3.34e-05	6.54e-04	17/43	TAGLN2; TUBA4A; MANF; WDR1; SPARC; PPIA; MAGED2; HSPA5; APLP2; PSAP; VCL; CD63; SCG3; ALDOA; LGALS3BP; CALM3; SOD1
R-HSA-983189	Kinesins	2.76	2.73e-03	1.81e-02	9/23	TUBA4A; TUBB2A; TUBB4B; KIF5B; TUBA1B; TUBA1A; TUBB3; KIF19; TUBB4A
R-HSA-163210	Formation of ATP by chemiosmotic coupling	2.75	8.46e-03	4.33e-02	7/18	ATP5F1; ATP5G3; ATP5C1; ATP5G2; ATP5B; ATP5H; ATP5J
R-HSA-1236974	ER-Phagosome pathway	2.68	2.24e-05	4.83e-04	19/50	PSMA5; PSMD4; RPS27A; PSMD6; HLA-A; PSMB1; PSMC2; PSMD13; UBC; PSME2; PSMA3; PDIA3; B2M; PSMA4; PSMD7; PSMB3; PSMC5; PSMA7; CALR
R-HSA-936837	Ion transport by P-type ATPases	2.65	3.83e-03	2.27e-02	9/24	ATP1B1; ATP1B3; CAMK2D; CAMK2B; SRI; FXYD6; FXYD1; FXYD7; CALM3
R-HSA-1236975	Antigen processing-Cross presentation	2.63	3.11e-05	6.38e-04	19/51	PSMA5; PSMD4; RPS27A; PSMD6; HLA-A; PSMB1; PSMC2; PSMD13; UBC; PSME2; PSMA3; PDIA3; B2M; PSMA4; PSMD7; PSMB3; PSMC5; PSMA7; CALR
R-HSA-180534	Vpu mediated degradation of CD4	2.63	1.35e-04	2.32e-03	16/43	PSMA5; PSMD4; RPS27A; PSMD6; SKP1; PSMB1; PSMC2; PSMD13; UBC; PSME2; PSMA3; PSMA4; PSMD7; PSMB3; PSMC5; PSMA7
R-HSA-69229	Ubiquitin-dependent degradation of Cyclin D1	2.57	1.84e-04	2.94e-03	16/44	PSMA5; PSMD4; RPS27A; PSMD6; PSMB1; PSMC2; PSMD13; CDK4; UBC; PSME2; PSMA3; PSMA4; PSMD7; PSMB3; PSMC5; PSMA7
R-HSA-75815	Ubiquitin-dependent degradation of Cyclin D	2.57	1.84e-04	2.94e-03	16/44	PSMA5; PSMD4; RPS27A; PSMD6; PSMB1; PSMC2; PSMD13; CDK4; UBC; PSME2; PSMA3; PSMA4; PSMD7; PSMB3; PSMC5; PSMA7
R-HSA-174113	SCF-beta-TrCP mediated degradation of Emi1	2.57	1.84e-04	2.94e-03	16/44	PSMA5; PSMD4; RPS27A; PSMD6; SKP1; PSMB1; PSMC2; PSMD13; UBC; PSME2; PSMA3; PSMA4; PSMD7; PSMB3; PSMC5; PSMA7
R-HSA-187577	SCF(Skp2)-mediated degradation of p27/p21	2.56	1.25e-04	2.20e-03	17/47	PSMA5; PSMD4; RPS27A; PSMD6; SKP1; PSMB1; PSMC2; PSMD13; CDK4; UBC; PSME2; PSMA3; PSMA4; PSMD7; PSMB3; PSMC5; PSMA7
R-HSA-71291	Metabolism of amino acids and derivatives	2.53	2.22e-16	8.31e-15	75/209	RPL22; RPL11; RPS8; RPL5; PSMA5; PHGDH; PSMD4; RPS27A; RPL31; RPL37A; RPL32; RPL15; RPSA; RPL14; PDHB; PSMD6; RPL35A; RPL9; RPL34; RPS3A; RPS23; RPS14; RPS10; RPS12; PSMB1; ASNS; PSMC2; PDHA1; HSD17B10; RPS4X; RPL36A; RPL10; RPL7; RPL30; RPS6; RPL35; RPL7A; PSMD13; RPL27A; RPS13; RPS24; RPS26; RPL41; RPL6; RPLP0; PXMP2; RPL21; PSME2; RPS29; PSMA3; CKB; RPL4; RPLP1; PSMA4; RPS17; RPS2; RPS15A; PSMD7; RPL13; RPL26; RPL23A; PSMB3; RPL19; RPL27; PSMC5; PSMA7; RPS15; RPS28; RPL18A; RPS16; RPS19; RPL18; RPL13A; RPS5; RPL3
R-HSA-6791226	Major pathway of rRNA processing in the nucleolus and cytosol	2.52	5.24e-12	1.80e-10	55/154	RPL22; RPL11; RPS8; RPL5; RPS27A; RPL31; RPL37A; RPL32; RPL15; RPSA; RPL14; RPL35A; RPL9; RPL34; RPS3A; RPS23; RPS14; RPS10; RPS12; RPS4X; RPL36A; RPL10; RPL7; RPL30; RPS6; RPL35; RPL7A; RPL27A; RPS13; RPS24; RPS26; RPL41; RPL6; RPLP0; RPL21; RPS29; RPL4; RPLP1; RPS17; RPS2; RPS15A; RPL13; RPL26; RPL23A; RPL19; RPL27; RPS15; RPS28; RPL18A; RPS16; RPS19; RPL18; RPL13A; RPS5; RPL3
R-HSA-8854050	FBXL7 down-regulates AURKA during mitotic entry and in early mitosis	2.51	2.49e-04	3.77e-03	16/45	PSMA5; PSMD4; RPS27A; PSMD6; SKP1; PSMB1; PSMC2; PSMD13; UBC; PSME2; PSMA3; PSMA4; PSMD7; PSMB3; PSMC5; PSMA7
R-HSA-373760	L1CAM interactions	2.49	8.41e-06	1.96e-04	24/68	CNTN2; SCN3A; TUBA4A; ALCAM; GAP43; ANK2; TUBB2A; CSNK2B; EZR; DCX; DPYSL2; SDCBP; CLTA; DNM1; VAV2; TUBB4B; NCAM1; HSPA8; ANK3; TUBA1B; TUBA1A; TUBB3; ACTG1; TUBB4A
R-HSA-211733	Regulation of activated PAK-2p34 by proteasome mediated degradation	2.46	4.92e-04	5.89e-03	15/43	PSMA5; PSMD4; RPS27A; PSMD6; PSMB1; PSMC2; PSMD13; UBC; PSME2; PSMA3; PSMA4; PSMD7; PSMB3; PSMC5; PSMA7
R-HSA-69601	Ubiquitin Mediated Degradation of Phosphorylated Cdc25A	2.46	4.92e-04	5.89e-03	15/43	PSMA5; PSMD4; RPS27A; PSMD6; PSMB1; PSMC2; PSMD13; UBC; PSME2; PSMA3; PSMA4; PSMD7; PSMB3; PSMC5; PSMA7
R-HSA-69610	p53-Independent DNA Damage Response	2.46	4.92e-04	5.89e-03	15/43	PSMA5; PSMD4; RPS27A; PSMD6; PSMB1; PSMC2; PSMD13; UBC; PSME2; PSMA3; PSMA4; PSMD7; PSMB3; PSMC5; PSMA7
R-HSA-69613	p53-Independent G1/S DNA damage checkpoint	2.46	4.92e-04	5.89e-03	15/43	PSMA5; PSMD4; RPS27A; PSMD6; PSMB1; PSMC2; PSMD13; UBC; PSME2; PSMA3; PSMA4; PSMD7; PSMB3; PSMC5; PSMA7
R-HSA-5610787	Hedgehog 'off' state	2.46	1.12e-05	2.48e-04	24/69	PSMA5; PSMD4; RPS27A; TUBA4A; PSMD6; IFT57; SKP1; TUBB2A; PSMB1; PSMC2; TUBB4B; PSMD13; TUBA1B; TUBA1A; UBC; PSME2; PSMA3; PSMA4; PSMD7; TUBB3; PSMB3; PSMC5; PSMA7; TUBB4A
R-HSA-180585	Vif-mediated degradation of APOBEC3G	2.46	3.33e-04	4.70e-03	16/46	PSMA5; PSMD4; RPS27A; PSMD6; PSMB1; PSMC2; TCEB1; PSMD13; UBC; PSME2; PSMA3; PSMA4; PSMD7; PSMB3; PSMC5; PSMA7
R-HSA-8868773	rRNA processing in the nucleus and cytosol	2.43	3.02e-11	9.63e-10	55/160	RPL22; RPL11; RPS8; RPL5; RPS27A; RPL31; RPL37A; RPL32; RPL15; RPSA; RPL14; RPL35A; RPL9; RPL34; RPS3A; RPS23; RPS14; RPS10; RPS12; RPS4X; RPL36A; RPL10; RPL7; RPL30; RPS6; RPL35; RPL7A; RPL27A; RPS13; RPS24; RPS26; RPL41; RPL6; RPLP0; RPL21; RPS29; RPL4; RPLP1; RPS17; RPS2; RPS15A; RPL13; RPL26; RPL23A; RPL19; RPL27; RPS15; RPS28; RPL18A; RPS16; RPS19; RPL18; RPL13A; RPS5; RPL3
R-HSA-422475	Axon guidance	2.41	0.00e+00	0.00e+00	112/328	RPL22; CDC42; RPL11; RPS8; RPL5; PSMA5; PSMD4; SHC1; EFNA3; CNTN2; RPS27A; RPL31; SCN3A; RPL37A; ARPC2; TUBA4A; SRGAP3; RPL32; RPL15; RPSA; RPL14; PSMD6; ROBO1; ALCAM; GAP43; RPL35A; RPL9; RPL34; ANK2; RPS3A; RPS23; RPS14; TUBB2A; CAP2; CSNK2B; RPS10; RPS12; EZR; PSMB1; ARPC1A; PSMC2; RPS4X; RPL36A; DCX; RPL10; DPYSL2; SDCBP; RPL7; TCEB1; RPL30; RPS6; CLTA; RPL35; DNM1; RPL7A; VAV2; TUBB4B; PSMD13; RPL27A; RPS13; NCAM1; HSPA8; ANK3; RPS24; MAGOHB; CACNB3; TUBA1B; TUBA1A; RPS26; RPL41; MYL6; SRGAP1; RPL6; RPLP0; UBC; RPL21; PSME2; RPS29; PSMA3; HSP90AA1; RPL4; RPLP1; PSMA4; RPS17; RPS2; RPS15A; PSMD7; RPL13; TUBB3; EFNB3; RPL26; RPL23A; PSMB3; RPL19; RPL27; PSMC5; EIF4A3; ACTG1; MYL12A; MYL12B; PSMA7; RPS15; TUBB4A; RPS28; RPL18A; PSENEN; RPS16; RPS19; RPL18; RPL13A; RPS5; RPL3
R-HSA-72312	rRNA processing	2.41	2.66e-11	8.82e-10	56/164	RPL22; RPL11; RPS8; RPL5; RPS27A; RPL31; RPL37A; RPL32; RPL15; RPSA; RPL14; RPL35A; RPL9; RPL34; RPS3A; RPS23; RPS14; RPS10; RPS12; HSD17B10; RPS4X; RPL36A; RPL10; RPL7; RPL30; RPS6; RPL35; RPL7A; RPL27A; RPS13; RPS24; RPS26; RPL41; RPL6; RPLP0; RPL21; RPS29; RPL4; RPLP1; RPS17; RPS2; RPS15A; RPL13; RPL26; RPL23A; RPL19; RPL27; RPS15; RPS28; RPL18A; RPS16; RPS19; RPL18; RPL13A; RPS5; RPL3
R-HSA-169911	Regulation of Apoptosis	2.41	6.52e-04	6.93e-03	15/44	PSMA5; PSMD4; RPS27A; PSMD6; PSMB1; PSMC2; PSMD13; UBC; PSME2; PSMA3; PSMA4; PSMD7; PSMB3; PSMC5; PSMA7
R-HSA-450408	AUF1 (hnRNP D0) binds and destabilizes mRNA	2.40	4.41e-04	5.58e-03	16/47	PSMA5; PSMD4; RPS27A; PSMD6; PSMB1; PSMC2; PSMD13; HSPA8; UBC; PSME2; PSMA3; PSMA4; PSMD7; PSMB3; PSMC5; PSMA7
R-HSA-5607761	Dectin-1 mediated noncanonical NF-kB signaling	2.40	4.41e-04	5.58e-03	16/47	PSMA5; PSMD4; RPS27A; PSMD6; SKP1; PSMB1; PSMC2; PSMD13; UBC; PSME2; PSMA3; PSMA4; PSMD7; PSMB3; PSMC5; PSMA7
R-HSA-5676590	NIK-->noncanonical NF-kB signaling	2.40	4.41e-04	5.58e-03	16/47	PSMA5; PSMD4; RPS27A; PSMD6; SKP1; PSMB1; PSMC2; PSMD13; UBC; PSME2; PSMA3; PSMA4; PSMD7; PSMB3; PSMC5; PSMA7
R-HSA-9604323	Negative regulation of NOTCH4 signaling	2.40	4.41e-04	5.58e-03	16/47	PSMA5; PSMD4; RPS27A; PSMD6; SKP1; PSMB1; PSMC2; PSMD13; UBC; PSME2; PSMA3; PSMA4; PSMD7; PSMB3; PSMC5; PSMA7
R-HSA-68949	Orc1 removal from chromatin	2.35	5.76e-04	6.36e-03	16/48	PSMA5; PSMD4; RPS27A; PSMD6; SKP1; PSMB1; PSMC2; PSMD13; UBC; PSME2; PSMA3; PSMA4; PSMD7; PSMB3; PSMC5; PSMA7
R-HSA-1169091	Activation of NF-kappaB in B cells	2.35	5.76e-04	6.36e-03	16/48	PSMA5; PSMD4; RPS27A; PSMD6; SKP1; PSMB1; PSMC2; PSMD13; UBC; PSME2; PSMA3; PSMA4; PSMD7; PSMB3; PSMC5; PSMA7
R-HSA-4608870	Asymmetric localization of PCP proteins	2.35	5.76e-04	6.36e-03	16/48	PSMA5; PSMD4; RPS27A; PSMD6; PSMB1; FZD1; PSMC2; PSMD13; UBC; PSME2; PSMA3; PSMA4; PSMD7; PSMB3; PSMC5; PSMA7
R-HSA-5610780	Degradation of GLI1 by the proteasome	2.35	5.76e-04	6.36e-03	16/48	PSMA5; PSMD4; RPS27A; PSMD6; SKP1; PSMB1; PSMC2; PSMD13; UBC; PSME2; PSMA3; PSMA4; PSMD7; PSMB3; PSMC5; PSMA7
R-HSA-5668541	TNFR2 non-canonical NF-kB pathway	2.35	5.76e-04	6.36e-03	16/48	PSMA5; PSMD4; RPS27A; PSMD6; SKP1; PSMB1; PSMC2; PSMD13; UBC; PSME2; PSMA3; PSMA4; PSMD7; PSMB3; PSMC5; PSMA7
R-HSA-349425	Autodegradation of the E3 ubiquitin ligase COP1	2.35	8.53e-04	8.35e-03	15/45	PSMA5; PSMD4; RPS27A; PSMD6; PSMB1; PSMC2; PSMD13; UBC; PSME2; PSMA3; PSMA4; PSMD7; PSMB3; PSMC5; PSMA7
R-HSA-4641258	Degradation of DVL	2.35	8.53e-04	8.35e-03	15/45	PSMA5; PSMD4; RPS27A; PSMD6; PSMB1; PSMC2; PSMD13; UBC; PSME2; PSMA3; PSMA4; PSMD7; PSMB3; PSMC5; PSMA7
R-HSA-68827	CDT1 association with the CDC6:ORC:origin complex	2.35	8.53e-04	8.35e-03	15/45	PSMA5; PSMD4; RPS27A; PSMD6; PSMB1; PSMC2; PSMD13; UBC; PSME2; PSMA3; PSMA4; PSMD7; PSMB3; PSMC5; PSMA7
R-HSA-8941858	Regulation of RUNX3 expression and activity	2.35	8.53e-04	8.35e-03	15/45	PSMA5; PSMD4; RPS27A; PSMD6; PSMB1; PSMC2; PSMD13; UBC; PSME2; PSMA3; PSMA4; PSMD7; PSMB3; PSMC5; PSMA7
R-HSA-1236978	Cross-presentation of soluble exogenous antigens (endosomes)	2.35	1.88e-03	1.41e-02	13/39	PSMA5; PSMD4; PSMD6; PSMB1; PSMC2; PSMD13; PSME2; PSMA3; PSMA4; PSMD7; PSMB3; PSMC5; PSMA7
R-HSA-5610783	Degradation of GLI2 by the proteasome	2.31	7.46e-04	7.65e-03	16/49	PSMA5; PSMD4; RPS27A; PSMD6; SKP1; PSMB1; PSMC2; PSMD13; UBC; PSME2; PSMA3; PSMA4; PSMD7; PSMB3; PSMC5; PSMA7
R-HSA-5610785	GLI3 is processed to GLI3R by the proteasome	2.31	7.46e-04	7.65e-03	16/49	PSMA5; PSMD4; RPS27A; PSMD6; SKP1; PSMB1; PSMC2; PSMD13; UBC; PSME2; PSMA3; PSMA4; PSMD7; PSMB3; PSMC5; PSMA7
R-HSA-4641257	Degradation of AXIN	2.30	1.10e-03	1.05e-02	15/46	PSMA5; PSMD4; RPS27A; PSMD6; PSMB1; PSMC2; PSMD13; UBC; PSME2; PSMA3; PSMA4; PSMD7; PSMB3; PSMC5; PSMA7
R-HSA-3371497	HSP90 chaperone cycle for steroid hormone receptors (SHR)	2.29	3.61e-03	2.16e-02	12/37	TUBA4A; TUBB2A; DNAJA1; TUBB4B; HSPA8; TUBA1B; TUBA1A; DYNLL1; ACTR10; HSP90AA1; TUBB3; TUBB4A
R-HSA-5362768	Hh mutants that don't undergo autocatalytic processing are degraded by ERAD	2.25	1.42e-03	1.24e-02	15/47	PSMA5; PSMD4; RPS27A; PSMD6; PSMB1; PSMC2; PSMD13; UBC; PSME2; PSMA3; PSMA4; PSMD7; PSMB3; PSMC5; PSMA7
R-HSA-5387390	Hh mutants abrogate ligand secretion	2.25	1.42e-03	1.24e-02	15/47	PSMA5; PSMD4; RPS27A; PSMD6; PSMB1; PSMC2; PSMD13; UBC; PSME2; PSMA3; PSMA4; PSMD7; PSMB3; PSMC5; PSMA7
R-HSA-68867	Assembly of the pre-replicative complex	2.25	1.42e-03	1.24e-02	15/47	PSMA5; PSMD4; RPS27A; PSMD6; PSMB1; PSMC2; PSMD13; UBC; PSME2; PSMA3; PSMA4; PSMD7; PSMB3; PSMC5; PSMA7
R-HSA-8939236	RUNX1 regulates transcription of genes involved in differentiation of HSCs	2.24	3.79e-04	5.18e-03	19/60	PSMA5; PSMD4; H3F3A; RPS27A; PSMD6; HIST1H4C; HIST1H2AC; PSMB1; PSMC2; PSMD13; UBC; PSME2; PSMA3; TCF12; PSMA4; PSMD7; PSMB3; PSMC5; PSMA7
R-HSA-8939902	Regulation of RUNX2 expression and activity	2.22	1.22e-03	1.13e-02	16/51	PSMA5; PSMD4; RPS27A; PSMD6; SKP1; PSMB1; PSMC2; PSMD13; UBC; PSME2; PSMA3; PSMA4; PSMD7; PSMB3; PSMC5; PSMA7
R-HSA-69541	Stabilization of p53	2.21	1.80e-03	1.41e-02	15/48	PSMA5; PSMD4; RPS27A; PSMD6; PSMB1; PSMC2; PSMD13; UBC; PSME2; PSMA3; PSMA4; PSMD7; PSMB3; PSMC5; PSMA7
R-HSA-1445148	Translocation of SLC2A4 (GLUT4) to the plasma membrane	2.20	2.66e-03	1.79e-02	14/45	RAB13; YWHAQ; TUBA4A; TUBB2A; TUBB4B; TUBA1B; TUBA1A; RAB11A; TUBB3; YWHAE; ACTG1; YWHAB; TUBB4A; CALM3
R-HSA-1168372	Downstream signaling events of B Cell Receptor (BCR)	2.19	7.06e-04	7.41e-03	18/58	PSMA5; PSMD4; RPS27A; PSMD6; SKP1; PSMB1; PPIA; PSMC2; PSMD13; UBC; PSME2; PSMA3; PSMA4; PSMD7; PSMB3; PSMC5; PSMA7; CALM3
R-HSA-5663205	Infectious disease	2.18	6.49e-14	2.33e-12	85/275	RPL22; RPL11; RPS8; RPL5; PSMA5; PSMD4; RPS27A; RPL31; RPL37A; RPL32; RPL15; RPSA; RPL14; PSMD6; RPL35A; RPL9; RPL34; RPS3A; RPS23; SKP1; RPS14; HMGA1; RPS10; RPS12; PSMB1; PPIA; STX1A; PSMC2; SLC25A6; RPS4X; RPL36A; RPL10; RPL7; TCEB1; RPL30; RPS6; CHMP5; CLTA; RPL35; RPL7A; PSMD13; RPL27A; RPS13; TSG101; RPS24; RPS26; RPL41; RPL6; RPLP0; UBC; RPL21; PSME2; RPS29; PSMA3; HSP90AA1; B2M; RPL4; RPLP1; PSMA4; RPS17; RPS2; RPS15A; PSMD7; RPL13; RPL26; RPL23A; PSMB3; RPL19; RPL27; PSMC5; KPNA2; SNAP25; PSMA7; RPS15; RPS28; CALR; RPL18A; RPS16; RPS19; CALM3; RPL18; RPL13A; RPS5; CHMP2A; RPL3
R-HSA-69563	p53-Dependent G1 DNA Damage Response	2.17	1.53e-03	1.26e-02	16/52	PSMA5; PSMD4; RPS27A; PSMD6; PSMB1; PSMC2; PSMD13; ZNF385A; UBC; PSME2; PSMA3; PSMA4; PSMD7; PSMB3; PSMC5; PSMA7
R-HSA-69580	p53-Dependent G1/S DNA damage checkpoint	2.17	1.53e-03	1.26e-02	16/52	PSMA5; PSMD4; RPS27A; PSMD6; PSMB1; PSMC2; PSMD13; ZNF385A; UBC; PSME2; PSMA3; PSMA4; PSMD7; PSMB3; PSMC5; PSMA7
R-HSA-69615	G1/S DNA Damage Checkpoints	2.17	1.53e-03	1.26e-02	16/52	PSMA5; PSMD4; RPS27A; PSMD6; PSMB1; PSMC2; PSMD13; ZNF385A; UBC; PSME2; PSMA3; PSMA4; PSMD7; PSMB3; PSMC5; PSMA7
R-HSA-1234176	Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha	2.17	1.53e-03	1.26e-02	16/52	PSMA5; PSMD4; RPS27A; PSMD6; PSMB1; PSMC2; TCEB1; PSMD13; UBC; PSME2; PSMA3; PSMA4; PSMD7; PSMB3; PSMC5; PSMA7
R-HSA-174084	Autodegradation of Cdh1 by Cdh1:APC/C	2.17	1.53e-03	1.26e-02	16/52	PSMA5; PSMD4; RPS27A; PSMD6; PSMB1; PSMC2; PSMD13; ANAPC5; UBC; PSME2; PSMA3; PSMA4; PSMD7; PSMB3; PSMC5; PSMA7
R-HSA-5678895	Defective CFTR causes cystic fibrosis	2.16	2.26e-03	1.62e-02	15/49	PSMA5; PSMD4; RPS27A; PSMD6; PSMB1; PSMC2; PSMD13; UBC; PSME2; PSMA3; PSMA4; PSMD7; PSMB3; PSMC5; PSMA7
R-HSA-983712	Ion channel transport	2.16	8.85e-04	8.47e-03	18/59	ATP6V0B; ATP1B1; RYR2; RPS27A; ATP1B3; CAMK2D; CAMK2B; SRI; ATP6AP1; ATP6V1G1; FXYD6; ASIC1; UBC; ATP6V0D1; TTYH2; FXYD1; FXYD7; CALM3
R-HSA-176408	Regulation of APC/C activators between G1/S and early anaphase	2.14	1.30e-03	1.18e-02	17/56	PSMA5; PSMD4; RPS27A; PSMD6; SKP1; PSMB1; PSMC2; PSMD13; ANAPC5; UBC; PSME2; PSMA3; PSMA4; PSMD7; PSMB3; PSMC5; PSMA7
R-HSA-350562	Regulation of ornithine decarboxylase (ODC)	2.14	4.93e-03	2.76e-02	13/43	PSMA5; PSMD4; PSMD6; PSMB1; PSMC2; PSMD13; PSME2; PSMA3; PSMA4; PSMD7; PSMB3; PSMC5; PSMA7
R-HSA-2871837	FCERI mediated NF-kB activation	2.13	1.92e-03	1.41e-02	16/53	PSMA5; PSMD4; RPS27A; PSMD6; SKP1; PSMB1; PSMC2; PSMD13; UBC; PSME2; PSMA3; PSMA4; PSMD7; PSMB3; PSMC5; PSMA7
R-HSA-69017	CDK-mediated phosphorylation and removal of Cdc6	2.13	1.92e-03	1.41e-02	16/53	PSMA5; PSMD4; RPS27A; PSMD6; PSMB1; PSMC2; PSMD13; ANAPC5; UBC; PSME2; PSMA3; PSMA4; PSMD7; PSMB3; PSMC5; PSMA7
R-HSA-202424	Downstream TCR signaling	2.13	1.92e-03	1.41e-02	16/53	PSMA5; PSMD4; RPS27A; PSMD6; SKP1; PSMB1; PSMC2; PSMD13; UBC; PSME2; PSMA3; PSMA4; PSMD7; PSMB3; PSMC5; PSMA7
R-HSA-390466	Chaperonin-mediated protein folding	2.13	1.92e-03	1.41e-02	16/53	GNG5; GNG4; CCT7; TUBA4A; GNAI2; CCT5; TUBB2A; CSNK2B; TCP1; TUBB4B; TUBA1B; TUBA1A; PFDN5; TUBB3; TUBB4A; GNG8
R-HSA-5358346	Hedgehog ligand biogenesis	2.12	2.82e-03	1.85e-02	15/50	PSMA5; PSMD4; RPS27A; PSMD6; PSMB1; PSMC2; PSMD13; UBC; PSME2; PSMA3; PSMA4; PSMD7; PSMB3; PSMC5; PSMA7
R-HSA-69202	Cyclin E associated events during G1/S transition	2.11	1.62e-03	1.28e-02	17/57	PSMA5; PSMD4; RPS27A; PSMD6; SKP1; PSMB1; PSMC2; PSMD13; CDK4; UBC; PSME2; PSMA3; PSMA4; PSMD7; PSMB3; PSMC5; PSMA7
R-HSA-69656	Cyclin A:Cdk2-associated events at S phase entry	2.11	1.62e-03	1.28e-02	17/57	PSMA5; PSMD4; RPS27A; PSMD6; SKP1; PSMB1; PSMC2; PSMD13; CDK4; UBC; PSME2; PSMA3; PSMA4; PSMD7; PSMB3; PSMC5; PSMA7
R-HSA-174143	APC/C-mediated degradation of cell cycle proteins	2.11	1.62e-03	1.28e-02	17/57	PSMA5; PSMD4; RPS27A; PSMD6; SKP1; PSMB1; PSMC2; PSMD13; ANAPC5; UBC; PSME2; PSMA3; PSMA4; PSMD7; PSMB3; PSMC5; PSMA7
R-HSA-453276	Regulation of mitotic cell cycle	2.11	1.62e-03	1.28e-02	17/57	PSMA5; PSMD4; RPS27A; PSMD6; SKP1; PSMB1; PSMC2; PSMD13; ANAPC5; UBC; PSME2; PSMA3; PSMA4; PSMD7; PSMB3; PSMC5; PSMA7
R-HSA-174154	APC/C:Cdc20 mediated degradation of Securin	2.09	2.38e-03	1.64e-02	16/54	PSMA5; PSMD4; RPS27A; PSMD6; PSMB1; PSMC2; PSMD13; ANAPC5; UBC; PSME2; PSMA3; PSMA4; PSMD7; PSMB3; PSMC5; PSMA7
R-HSA-174178	APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1	2.09	2.38e-03	1.64e-02	16/54	PSMA5; PSMD4; RPS27A; PSMD6; PSMB1; PSMC2; PSMD13; ANAPC5; UBC; PSME2; PSMA3; PSMA4; PSMD7; PSMB3; PSMC5; PSMA7
R-HSA-174184	Cdc20:Phospho-APC/C mediated degradation of Cyclin A	2.09	2.38e-03	1.64e-02	16/54	PSMA5; PSMD4; RPS27A; PSMD6; PSMB1; PSMC2; PSMD13; ANAPC5; UBC; PSME2; PSMA3; PSMA4; PSMD7; PSMB3; PSMC5; PSMA7
R-HSA-179419	APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint	2.09	2.38e-03	1.64e-02	16/54	PSMA5; PSMD4; RPS27A; PSMD6; PSMB1; PSMC2; PSMD13; ANAPC5; UBC; PSME2; PSMA3; PSMA4; PSMD7; PSMB3; PSMC5; PSMA7
R-HSA-5619084	ABC transporter disorders	2.08	3.49e-03	2.13e-02	15/51	PSMA5; PSMD4; RPS27A; PSMD6; PSMB1; PSMC2; PSMD13; UBC; PSME2; PSMA3; PSMA4; PSMD7; PSMB3; PSMC5; PSMA7
R-HSA-9013694	Signaling by NOTCH4	2.07	2.00e-03	1.46e-02	17/58	PSMA5; PSMD4; RPS27A; PSMD6; SKP1; PSMB1; PSMC2; PSMD13; UBC; PSME2; PSMA3; PSMA4; PSMD7; PSMB3; PSMC5; PSMA7; PSENEN
R-HSA-5358351	Signaling by Hedgehog	2.07	2.60e-04	3.86e-03	24/82	PSMA5; PSMD4; RPS27A; TUBA4A; PSMD6; IFT57; SKP1; TUBB2A; PSMB1; PSMC2; TUBB4B; PSMD13; TUBA1B; TUBA1A; UBC; PSME2; PSMA3; PSMA4; PSMD7; TUBB3; PSMB3; PSMC5; PSMA7; TUBB4A
R-HSA-8948751	Regulation of PTEN stability and activity	2.05	2.92e-03	1.87e-02	16/55	PSMA5; PSMD4; RPS27A; PSMD6; CSNK2B; PSMB1; PSMC2; PSMD13; UBC; PSME2; PSMA3; PSMA4; PSMD7; PSMB3; PSMC5; PSMA7
R-HSA-176409	APC/C:Cdc20 mediated degradation of mitotic proteins	2.05	2.92e-03	1.87e-02	16/55	PSMA5; PSMD4; RPS27A; PSMD6; PSMB1; PSMC2; PSMD13; ANAPC5; UBC; PSME2; PSMA3; PSMA4; PSMD7; PSMB3; PSMC5; PSMA7
R-HSA-176814	Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins	2.05	2.92e-03	1.87e-02	16/55	PSMA5; PSMD4; RPS27A; PSMD6; PSMB1; PSMC2; PSMD13; ANAPC5; UBC; PSME2; PSMA3; PSMA4; PSMD7; PSMB3; PSMC5; PSMA7
R-HSA-5658442	Regulation of RAS by GAPs	2.04	4.28e-03	2.44e-02	15/52	PSMA5; PSMD4; RPS27A; PSMD6; PSMB1; PSMC2; PSMD13; UBC; PSME2; PSMA3; PSMA4; PSMD7; PSMB3; PSMC5; PSMA7
R-HSA-69002	DNA Replication Pre-Initiation	2.04	4.28e-03	2.44e-02	15/52	PSMA5; PSMD4; RPS27A; PSMD6; PSMB1; PSMC2; PSMD13; UBC; PSME2; PSMA3; PSMA4; PSMD7; PSMB3; PSMC5; PSMA7
R-HSA-5632684	Hedgehog 'on' state	2.04	4.28e-03	2.44e-02	15/52	PSMA5; PSMD4; RPS27A; PSMD6; PSMB1; PSMC2; PSMD13; UBC; PSME2; PSMA3; PSMA4; PSMD7; PSMB3; PSMC5; PSMA7
R-HSA-69052	Switching of origins to a post-replicative state	2.04	2.45e-03	1.66e-02	17/59	PSMA5; PSMD4; RPS27A; PSMD6; SKP1; PSMB1; PSMC2; PSMD13; ANAPC5; UBC; PSME2; PSMA3; PSMA4; PSMD7; PSMB3; PSMC5; PSMA7
R-HSA-9020702	Interleukin-1 signaling	2.04	2.45e-03	1.66e-02	17/59	PSMA5; PSMD4; RPS27A; PSMD6; SKP1; PSMB1; PSMC2; PSMD13; UBC; PSME2; PELI2; PSMA3; PSMA4; PSMD7; PSMB3; PSMC5; PSMA7
R-HSA-76002	Platelet activation, signaling and aggregation	2.03	2.67e-04	3.89e-03	25/87	PRKCZ; CDC42; GNG5; SHC1; TAGLN2; GNG4; TUBA4A; GNAI2; MANF; WDR1; SPARC; PPIA; MAGED2; HSPA5; VAV2; APLP2; PSAP; VCL; CD63; SCG3; ALDOA; LGALS3BP; CALM3; GNG8; SOD1
R-HSA-382556	ABC-family proteins mediated transport	2.02	3.57e-03	2.15e-02	16/56	PSMA5; PSMD4; RPS27A; PSMD6; PSMB1; PSMC2; PSMD13; UBC; PSME2; PSMA3; PSMA4; PSMD7; PSMB3; PSMC5; EIF2S2; PSMA7
R-HSA-5607764	CLEC7A (Dectin-1) signaling	2.00	2.98e-03	1.87e-02	17/60	PSMA5; PSMD4; RPS27A; PSMD6; SKP1; PSMB1; PSMC2; PSMD13; UBC; PSME2; PSMA3; PSMA4; PSMD7; PSMB3; PSMC5; PSMA7; CALM3
R-HSA-1266738	Developmental Biology	2.00	0.00e+00	0.00e+00	126/445	RPL22; CDC42; RPL11; RPS8; JUN; RPL5; PSMA5; PSMD4; SHC1; EFNA3; CNTN2; H3F3A; NCOA1; RPS27A; RPL31; PKP4; SCN3A; NEUROD1; RPL37A; ARPC2; TUBA4A; SRGAP3; RPL32; RPL15; RPSA; RPL14; PSMD6; ROBO1; ALCAM; GAP43; RPL35A; RPL9; RPL34; ANK2; RPS3A; RPS23; RPS14; EBF1; TUBB2A; CAP2; HIST1H4C; HIST1H2AC; CSNK2B; RPS10; RPS12; EZR; PSMB1; STX1A; ARPC1A; PSMC2; RPS4X; RPL36A; DCX; RPL10; DPYSL2; SDCBP; RPL7; TCEB1; RPL30; RPS6; CLTA; RPL35; DNM1; RPL7A; VAV2; TUBB4B; PSMD13; RPL27A; RPS13; NCAM1; HSPA8; ANK3; RPS24; MAGOHB; CACNB3; TUBA1B; TUBA1A; RPS26; RPL41; MYL6; CDK4; SRGAP1; RPL6; RPLP0; UBC; RPL21; PSME2; RPS29; PSMA3; HSP90AA1; TCF12; RPL4; RPLP1; PSMA4; RPS17; RPS2; RPS15A; PSMD7; RPL13; TUBB3; EFNB3; RPL26; RPL23A; PSMB3; RPL19; RPL27; PSMC5; EIF4A3; ACTG1; MYL12A; MYL12B; TCF4; PSMA7; RPS15; TUBB4A; RPS28; RPL18A; LGI4; PSENEN; CAPNS1; RPS16; RPS19; RPL18; RPL13A; RPS5; RPL3

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ARID1B : 59 significant Reactome pathways

GeneSet	description	enrichRatio	pValue	FDR	GeneRatio	geneSymbols
R-HSA-192823	Viral mRNA Translation	8.36	0.00e+00	0.00e+00	49/83	RPL11; RPS8; RPL5; RPS27; RPS27A; RPL37A; RPL32; RPL15; RPSA; RPL22L1; RPL9; RPS3A; RPL37; RPS23; RPS14; RPS18; RPL10A; RPS12; RPS4X; RPL36A; RPL39; RPS20; RPL7; RPL30; RPS6; RPL7A; RPL27A; RPS13; RPS3; RPS24; RPS26; RPL6; RPLP0; RPL21; RPL36AL; RPL4; RPS17; RPS2; RPS15A; RPL13; RPL26; RPL23A; RPL23; RPL19; RPL18A; RPS19; RPL18; RPL13A; RPL3
R-HSA-156902	Peptide chain elongation	8.26	0.00e+00	0.00e+00	49/84	RPL11; RPS8; RPL5; RPS27; RPS27A; RPL37A; RPL32; RPL15; RPSA; RPL22L1; RPL9; RPS3A; RPL37; RPS23; RPS14; RPS18; RPL10A; RPS12; RPS4X; RPL36A; RPL39; RPS20; RPL7; RPL30; RPS6; RPL7A; RPL27A; RPS13; RPS3; RPS24; RPS26; RPL6; RPLP0; RPL21; RPL36AL; RPL4; RPS17; RPS2; RPS15A; RPL13; RPL26; RPL23A; RPL23; RPL19; RPL18A; RPS19; RPL18; RPL13A; RPL3
R-HSA-2408557	Selenocysteine synthesis	8.16	0.00e+00	0.00e+00	49/85	RPL11; RPS8; RPL5; RPS27; RPS27A; RPL37A; RPL32; RPL15; RPSA; RPL22L1; RPL9; RPS3A; RPL37; RPS23; RPS14; RPS18; RPL10A; RPS12; RPS4X; RPL36A; RPL39; RPS20; RPL7; RPL30; RPS6; RPL7A; RPL27A; RPS13; RPS3; RPS24; RPS26; RPL6; RPLP0; RPL21; RPL36AL; RPL4; RPS17; RPS2; RPS15A; RPL13; RPL26; RPL23A; RPL23; RPL19; RPL18A; RPS19; RPL18; RPL13A; RPL3
R-HSA-156842	Eukaryotic Translation Elongation	8.07	0.00e+00	0.00e+00	49/86	RPL11; RPS8; RPL5; RPS27; RPS27A; RPL37A; RPL32; RPL15; RPSA; RPL22L1; RPL9; RPS3A; RPL37; RPS23; RPS14; RPS18; RPL10A; RPS12; RPS4X; RPL36A; RPL39; RPS20; RPL7; RPL30; RPS6; RPL7A; RPL27A; RPS13; RPS3; RPS24; RPS26; RPL6; RPLP0; RPL21; RPL36AL; RPL4; RPS17; RPS2; RPS15A; RPL13; RPL26; RPL23A; RPL23; RPL19; RPL18A; RPS19; RPL18; RPL13A; RPL3
R-HSA-72764	Eukaryotic Translation Termination	8.07	0.00e+00	0.00e+00	49/86	RPL11; RPS8; RPL5; RPS27; RPS27A; RPL37A; RPL32; RPL15; RPSA; RPL22L1; RPL9; RPS3A; RPL37; RPS23; RPS14; RPS18; RPL10A; RPS12; RPS4X; RPL36A; RPL39; RPS20; RPL7; RPL30; RPS6; RPL7A; RPL27A; RPS13; RPS3; RPS24; RPS26; RPL6; RPLP0; RPL21; RPL36AL; RPL4; RPS17; RPS2; RPS15A; RPL13; RPL26; RPL23A; RPL23; RPL19; RPL18A; RPS19; RPL18; RPL13A; RPL3
R-HSA-72689	Formation of a pool of free 40S subunits	7.90	0.00e+00	0.00e+00	53/95	RPL11; RPS8; RPL5; RPS27; RPS27A; RPL37A; RPL32; RPL15; RPSA; RPL22L1; RPL9; RPS3A; RPL37; RPS23; RPS14; RPS18; RPL10A; RPS12; RPS4X; RPL36A; RPL39; RPS20; RPL7; RPL30; EIF3E; EIF3H; RPS6; RPL7A; EIF3F; RPL27A; RPS13; RPS3; RPS24; RPS26; RPL6; RPLP0; RPL21; RPL36AL; RPL4; RPS17; RPS2; RPS15A; RPL13; RPL26; RPL23A; RPL23; RPL19; RPL18A; RPS19; RPL18; RPL13A; EIF3L; RPL3
R-HSA-975956	Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)	7.88	0.00e+00	0.00e+00	49/88	RPL11; RPS8; RPL5; RPS27; RPS27A; RPL37A; RPL32; RPL15; RPSA; RPL22L1; RPL9; RPS3A; RPL37; RPS23; RPS14; RPS18; RPL10A; RPS12; RPS4X; RPL36A; RPL39; RPS20; RPL7; RPL30; RPS6; RPL7A; RPL27A; RPS13; RPS3; RPS24; RPS26; RPL6; RPLP0; RPL21; RPL36AL; RPL4; RPS17; RPS2; RPS15A; RPL13; RPL26; RPL23A; RPL23; RPL19; RPL18A; RPS19; RPL18; RPL13A; RPL3
R-HSA-1799339	SRP-dependent cotranslational protein targeting to membrane	7.35	0.00e+00	0.00e+00	54/104	RPL11; RPS8; RPL5; RPS27; RPS27A; RPL37A; RPL32; RPL15; RPSA; SPCS1; RPL22L1; RPL9; RPS3A; RPL37; RPS23; RPS14; RPS18; RPL10A; RPS12; SEC61G; RPS4X; RPL36A; RPL39; SSR4; RPS20; RPL7; RPL30; RPS6; SEC61B; RPL7A; RPL27A; RPS13; RPS3; RPS24; RPS26; RPL6; RPLP0; RPL21; RPL36AL; SRP14; RPL4; RPS17; RPS2; RPS15A; RPL13; RPL26; RPL23A; RPL23; RPL19; RPL18A; RPS19; RPL18; RPL13A; RPL3
R-HSA-156827	L13a-mediated translational silencing of Ceruloplasmin expression	7.15	0.00e+00	0.00e+00	53/105	RPL11; RPS8; RPL5; RPS27; RPS27A; RPL37A; RPL32; RPL15; RPSA; RPL22L1; RPL9; RPS3A; RPL37; RPS23; RPS14; RPS18; RPL10A; RPS12; RPS4X; RPL36A; RPL39; RPS20; RPL7; RPL30; EIF3E; EIF3H; RPS6; RPL7A; EIF3F; RPL27A; RPS13; RPS3; RPS24; RPS26; RPL6; RPLP0; RPL21; RPL36AL; RPL4; RPS17; RPS2; RPS15A; RPL13; RPL26; RPL23A; RPL23; RPL19; RPL18A; RPS19; RPL18; RPL13A; EIF3L; RPL3
R-HSA-72706	GTP hydrolysis and joining of the 60S ribosomal subunit	7.08	0.00e+00	0.00e+00	53/106	RPL11; RPS8; RPL5; RPS27; RPS27A; RPL37A; RPL32; RPL15; RPSA; RPL22L1; RPL9; RPS3A; RPL37; RPS23; RPS14; RPS18; RPL10A; RPS12; RPS4X; RPL36A; RPL39; RPS20; RPL7; RPL30; EIF3E; EIF3H; RPS6; RPL7A; EIF3F; RPL27A; RPS13; RPS3; RPS24; RPS26; RPL6; RPLP0; RPL21; RPL36AL; RPL4; RPS17; RPS2; RPS15A; RPL13; RPL26; RPL23A; RPL23; RPL19; RPL18A; RPS19; RPL18; RPL13A; EIF3L; RPL3
R-HSA-72695	Formation of the ternary complex, and subsequently, the 43S complex	7.08	5.55e-16	1.59e-14	24/48	RPS8; RPS27; RPS27A; RPSA; RPS3A; RPS23; RPS14; RPS18; RPS12; RPS4X; RPS20; EIF3E; EIF3H; RPS6; EIF3F; RPS13; RPS3; RPS24; RPS26; RPS17; RPS2; RPS15A; RPS19; EIF3L
R-HSA-163210	Formation of ATP by chemiosmotic coupling	7.08	1.05e-06	2.32e-05	9/18	ATP5G3; ATP5I; ATP5J2; ATP5L; ATP5G2; ATP5G1; ATP5H; ATP5E; ATP5J
R-HSA-2408522	Selenoamino acid metabolism	7.01	0.00e+00	0.00e+00	49/99	RPL11; RPS8; RPL5; RPS27; RPS27A; RPL37A; RPL32; RPL15; RPSA; RPL22L1; RPL9; RPS3A; RPL37; RPS23; RPS14; RPS18; RPL10A; RPS12; RPS4X; RPL36A; RPL39; RPS20; RPL7; RPL30; RPS6; RPL7A; RPL27A; RPS13; RPS3; RPS24; RPS26; RPL6; RPLP0; RPL21; RPL36AL; RPL4; RPS17; RPS2; RPS15A; RPL13; RPL26; RPL23A; RPL23; RPL19; RPL18A; RPS19; RPL18; RPL13A; RPL3
R-HSA-72613	Eukaryotic Translation Initiation	6.76	0.00e+00	0.00e+00	54/113	RPL11; RPS8; RPL5; RPS27; RPS27A; RPL37A; RPL32; RPL15; RPSA; RPL22L1; RPL9; RPS3A; RPL37; RPS23; RPS14; RPS18; RPL10A; RPS12; RPS4X; RPL36A; RPL39; EIF4EBP1; RPS20; RPL7; RPL30; EIF3E; EIF3H; RPS6; RPL7A; EIF3F; RPL27A; RPS13; RPS3; RPS24; RPS26; RPL6; RPLP0; RPL21; RPL36AL; RPL4; RPS17; RPS2; RPS15A; RPL13; RPL26; RPL23A; RPL23; RPL19; RPL18A; RPS19; RPL18; RPL13A; EIF3L; RPL3
R-HSA-72737	Cap-dependent Translation Initiation	6.76	0.00e+00	0.00e+00	54/113	RPL11; RPS8; RPL5; RPS27; RPS27A; RPL37A; RPL32; RPL15; RPSA; RPL22L1; RPL9; RPS3A; RPL37; RPS23; RPS14; RPS18; RPL10A; RPS12; RPS4X; RPL36A; RPL39; EIF4EBP1; RPS20; RPL7; RPL30; EIF3E; EIF3H; RPS6; RPL7A; EIF3F; RPL27A; RPS13; RPS3; RPS24; RPS26; RPL6; RPLP0; RPL21; RPL36AL; RPL4; RPS17; RPS2; RPS15A; RPL13; RPL26; RPL23A; RPL23; RPL19; RPL18A; RPS19; RPL18; RPL13A; EIF3L; RPL3
R-HSA-168273	Influenza Viral RNA Transcription and Replication	6.76	0.00e+00	0.00e+00	54/113	RPL11; RPS8; RPL5; RPS27; RPS27A; RPL37A; RPL32; RPL15; RPSA; RPL22L1; RPL9; RPS3A; RPL37; RPS23; RPS14; RPS18; RPL10A; RPS12; POLR2J; RPS4X; RPL36A; RPL39; RPS20; RPL7; RPL30; POLR2K; RPS6; RPL7A; POLR2L; RPL27A; RPS13; RPS3; RPS24; RPS26; RPL6; RPLP0; RPL21; RPL36AL; RPL4; RPS17; RPS2; RPS15A; RPL13; RPL26; RPL23A; RPL23; RPL19; RPL18A; POLR2I; RPS19; RPL18; RPL13A; POLR2F; RPL3
R-HSA-927802	Nonsense-Mediated Decay (NMD)	6.61	0.00e+00	0.00e+00	49/105	RPL11; RPS8; RPL5; RPS27; RPS27A; RPL37A; RPL32; RPL15; RPSA; RPL22L1; RPL9; RPS3A; RPL37; RPS23; RPS14; RPS18; RPL10A; RPS12; RPS4X; RPL36A; RPL39; RPS20; RPL7; RPL30; RPS6; RPL7A; RPL27A; RPS13; RPS3; RPS24; RPS26; RPL6; RPLP0; RPL21; RPL36AL; RPL4; RPS17; RPS2; RPS15A; RPL13; RPL26; RPL23A; RPL23; RPL19; RPL18A; RPS19; RPL18; RPL13A; RPL3
R-HSA-975957	Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)	6.61	0.00e+00	0.00e+00	49/105	RPL11; RPS8; RPL5; RPS27; RPS27A; RPL37A; RPL32; RPL15; RPSA; RPL22L1; RPL9; RPS3A; RPL37; RPS23; RPS14; RPS18; RPL10A; RPS12; RPS4X; RPL36A; RPL39; RPS20; RPL7; RPL30; RPS6; RPL7A; RPL27A; RPS13; RPS3; RPS24; RPS26; RPL6; RPLP0; RPL21; RPL36AL; RPL4; RPS17; RPS2; RPS15A; RPL13; RPL26; RPL23A; RPL23; RPL19; RPL18A; RPS19; RPL18; RPL13A; RPL3
R-HSA-72662	Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S	6.32	4.11e-15	1.14e-13	25/56	RPS8; RPS27; RPS27A; RPSA; RPS3A; RPS23; RPS14; RPS18; RPS12; RPS4X; EIF4EBP1; RPS20; EIF3E; EIF3H; RPS6; EIF3F; RPS13; RPS3; RPS24; RPS26; RPS17; RPS2; RPS15A; RPS19; EIF3L
R-HSA-168255	Influenza Life Cycle	6.32	0.00e+00	0.00e+00	54/121	RPL11; RPS8; RPL5; RPS27; RPS27A; RPL37A; RPL32; RPL15; RPSA; RPL22L1; RPL9; RPS3A; RPL37; RPS23; RPS14; RPS18; RPL10A; RPS12; POLR2J; RPS4X; RPL36A; RPL39; RPS20; RPL7; RPL30; POLR2K; RPS6; RPL7A; POLR2L; RPL27A; RPS13; RPS3; RPS24; RPS26; RPL6; RPLP0; RPL21; RPL36AL; RPL4; RPS17; RPS2; RPS15A; RPL13; RPL26; RPL23A; RPL23; RPL19; RPL18A; POLR2I; RPS19; RPL18; RPL13A; POLR2F; RPL3
R-HSA-3299685	Detoxification of Reactive Oxygen Species	6.29	1.30e-05	2.74e-04	8/18	PRDX1; ATOX1; CYCS; TXN; PRDX5; GSTP1; PRDX2; SOD1
R-HSA-6799198	Complex I biogenesis	6.26	7.04e-14	1.78e-12	23/52	NDUFS5; NDUFB3; NDUFAF3; NDUFB4; NDUFA2; NDUFB2; NDUFB11; NDUFA1; NDUFB9; NDUFB6; NDUFS8; NDUFC2; NDUFB8; NDUFB1; NDUFB10; NDUFS7; NDUFA11; NDUFA7; NDUFB7; NDUFA13; NDUFA3; NDUFA6; MT-ND3
R-HSA-163200	Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.	6.21	0.00e+00	0.00e+00	50/114	NDUFS5; UQCRH; COX20; COX5B; ATP5G3; NDUFB3; NDUFAF3; NDUFB4; ATP5I; COX7C; UQCRQ; NDUFA2; NDUFA4; CYCS; ATP5J2; NDUFB2; NDUFB11; COX7B; NDUFA1; COX6C; NDUFB9; NDUFB6; COX8A; NDUFS8; NDUFC2; ATP5L; NDUFB8; COX14; ATP5G2; COX16; NDUFB1; COX5A; NDUFB10; COX4I1; ATP5G1; ATP5H; ATP5E; NDUFS7; UQCR11; NDUFA11; NDUFA7; NDUFB7; NDUFA13; COX6B1; NDUFA3; UQCR10; NDUFA6; ATP5J; MT-CO1; MT-ND3
R-HSA-72649	Translation initiation complex formation	6.18	2.83e-14	7.39e-13	24/55	RPS8; RPS27; RPS27A; RPSA; RPS3A; RPS23; RPS14; RPS18; RPS12; RPS4X; RPS20; EIF3E; EIF3H; RPS6; EIF3F; RPS13; RPS3; RPS24; RPS26; RPS17; RPS2; RPS15A; RPS19; EIF3L
R-HSA-72702	Ribosomal scanning and start codon recognition	6.18	2.83e-14	7.39e-13	24/55	RPS8; RPS27; RPS27A; RPSA; RPS3A; RPS23; RPS14; RPS18; RPS12; RPS4X; RPS20; EIF3E; EIF3H; RPS6; EIF3F; RPS13; RPS3; RPS24; RPS26; RPS17; RPS2; RPS15A; RPS19; EIF3L
R-HSA-611105	Respiratory electron transport	6.11	0.00e+00	0.00e+00	41/95	NDUFS5; UQCRH; COX20; COX5B; NDUFB3; NDUFAF3; NDUFB4; COX7C; UQCRQ; NDUFA2; NDUFA4; CYCS; NDUFB2; NDUFB11; COX7B; NDUFA1; COX6C; NDUFB9; NDUFB6; COX8A; NDUFS8; NDUFC2; NDUFB8; COX14; COX16; NDUFB1; COX5A; NDUFB10; COX4I1; NDUFS7; UQCR11; NDUFA11; NDUFA7; NDUFB7; NDUFA13; COX6B1; NDUFA3; UQCR10; NDUFA6; MT-CO1; MT-ND3
R-HSA-168254	Influenza Infection	5.97	0.00e+00	0.00e+00	54/128	RPL11; RPS8; RPL5; RPS27; RPS27A; RPL37A; RPL32; RPL15; RPSA; RPL22L1; RPL9; RPS3A; RPL37; RPS23; RPS14; RPS18; RPL10A; RPS12; POLR2J; RPS4X; RPL36A; RPL39; RPS20; RPL7; RPL30; POLR2K; RPS6; RPL7A; POLR2L; RPL27A; RPS13; RPS3; RPS24; RPS26; RPL6; RPLP0; RPL21; RPL36AL; RPL4; RPS17; RPS2; RPS15A; RPL13; RPL26; RPL23A; RPL23; RPL19; RPL18A; POLR2I; RPS19; RPL18; RPL13A; POLR2F; RPL3
R-HSA-5601884	PIWI-interacting RNA (piRNA) biogenesis	5.44	1.36e-03	2.49e-02	5/13	POLR2J; POLR2K; POLR2L; POLR2I; POLR2F
R-HSA-9010553	Regulation of expression of SLITs and ROBOs	5.04	0.00e+00	0.00e+00	53/149	RPL11; RPS8; RPL5; RPS27; RPS27A; RPL37A; RPL32; RPL15; RPSA; RPL22L1; RPL9; RPS3A; RPL37; RPS23; RPS14; RPS18; RPL10A; RPS12; SHFM1; RPS4X; RPL36A; RPL39; RPS20; RPL7; TCEB1; RPL30; RPS6; RPL7A; RPL27A; RPS13; RPS3; RPS24; RPS26; RPL6; RPLP0; RPL21; RPL36AL; RPL4; RPS17; RPS2; TCEB2; RPS15A; RPL13; RPL26; RPL23A; RPL23; RPL19; RPL18A; RPS19; RPL18; RPL13A; RPL3; RBX1
R-HSA-1428517	The citric acid (TCA) cycle and respiratory electron transport	4.95	0.00e+00	0.00e+00	50/143	NDUFS5; UQCRH; COX20; COX5B; ATP5G3; NDUFB3; NDUFAF3; NDUFB4; ATP5I; COX7C; UQCRQ; NDUFA2; NDUFA4; CYCS; ATP5J2; NDUFB2; NDUFB11; COX7B; NDUFA1; COX6C; NDUFB9; NDUFB6; COX8A; NDUFS8; NDUFC2; ATP5L; NDUFB8; COX14; ATP5G2; COX16; NDUFB1; COX5A; NDUFB10; COX4I1; ATP5G1; ATP5H; ATP5E; NDUFS7; UQCR11; NDUFA11; NDUFA7; NDUFB7; NDUFA13; COX6B1; NDUFA3; UQCR10; NDUFA6; ATP5J; MT-CO1; MT-ND3
R-HSA-5628897	TP53 Regulates Metabolic Genes	4.72	2.13e-10	4.82e-09	22/66	PRDX1; LAMTOR5; LAMTOR2; COX20; COX5B; COX7C; NDUFA4; CYCS; LAMTOR4; COX7B; COX6C; YWHAZ; TXN; COX8A; PRDX5; COX14; COX16; COX5A; COX4I1; PRDX2; COX6B1; MT-CO1
R-HSA-8949613	Cristae formation	4.72	2.20e-05	4.51e-04	10/30	MINOS1; ATP5G3; ATP5I; ATP5J2; ATP5L; ATP5G2; ATP5G1; ATP5H; ATP5E; ATP5J
R-HSA-8868773	rRNA processing in the nucleus and cytosol	4.69	0.00e+00	0.00e+00	53/160	RPL11; RPS8; RPL5; RPS27; RPS27A; RPL37A; NCL; RPL32; RPL15; RPSA; RPL22L1; RPL9; RPS3A; RPL37; RPS23; RPS14; NHP2; RPS18; RPL10A; RPS12; RPS4X; RPL36A; RPL39; RPS20; RPL7; RPL30; RPS6; RPL7A; RPL27A; RPS13; RPS3; RPS24; RPS26; RPL6; RPLP0; RPL21; RPL36AL; NOP10; RPL4; RPS17; RPS2; RPS15A; RPL13; RPL26; RPL23A; RPL23; RPL19; RPL18A; RPS19; RPL18; RPL13A; RPL3; SNU13
R-HSA-6791226	Major pathway of rRNA processing in the nucleolus and cytosol	4.69	0.00e+00	0.00e+00	51/154	RPL11; RPS8; RPL5; RPS27; RPS27A; RPL37A; NCL; RPL32; RPL15; RPSA; RPL22L1; RPL9; RPS3A; RPL37; RPS23; RPS14; RPS18; RPL10A; RPS12; RPS4X; RPL36A; RPL39; RPS20; RPL7; RPL30; RPS6; RPL7A; RPL27A; RPS13; RPS3; RPS24; RPS26; RPL6; RPLP0; RPL21; RPL36AL; RPL4; RPS17; RPS2; RPS15A; RPL13; RPL26; RPL23A; RPL23; RPL19; RPL18A; RPS19; RPL18; RPL13A; RPL3; SNU13
R-HSA-72312	rRNA processing	4.66	0.00e+00	0.00e+00	54/164	RPL11; RPS8; RPL5; RPS27; RPS27A; RPL37A; NCL; RPL32; RPL15; RPSA; RPL22L1; RPL9; RPS3A; RPL37; RPS23; RPS14; NHP2; RPS18; RPL10A; RPS12; HSD17B10; RPS4X; RPL36A; RPL39; RPS20; RPL7; RPL30; RPS6; RPL7A; RPL27A; RPS13; RPS3; RPS24; RPS26; RPL6; RPLP0; RPL21; RPL36AL; NOP10; RPL4; RPS17; RPS2; RPS15A; RPL13; RPL26; RPL23A; RPL23; RPL19; RPL18A; RPS19; RPL18; RPL13A; RPL3; SNU13
R-HSA-376176	Signaling by ROBO receptors	4.29	0.00e+00	0.00e+00	54/178	RPL11; RPS8; RPL5; RPS27; RPS27A; RPL37A; RPL32; RPL15; RPSA; RPL22L1; RPL9; RPS3A; RPL37; RPS23; RPS14; RPS18; RPL10A; RPS12; SHFM1; RPS4X; RPL36A; RPL39; RPS20; RPL7; TCEB1; RPL30; RPS6; RPL7A; RPL27A; RPS13; RPS3; RPS24; RPS26; RPL6; RPLP0; RPL21; RPL36AL; RPL4; RPS17; RPS2; TCEB2; RPS15A; RPL13; PFN1; RPL26; RPL23A; RPL23; RPL19; RPL18A; RPS19; RPL18; RPL13A; RPL3; RBX1
R-HSA-167160	RNA Pol II CTD phosphorylation and interaction with CE during HIV infection	4.25	1.95e-03	3.17e-02	6/20	GTF2H5; POLR2J; POLR2K; POLR2L; POLR2I; POLR2F
R-HSA-77075	RNA Pol II CTD phosphorylation and interaction with CE	4.25	1.95e-03	3.17e-02	6/20	GTF2H5; POLR2J; POLR2K; POLR2L; POLR2I; POLR2F
R-HSA-73777	RNA Polymerase I Chain Elongation	4.04	4.97e-04	9.52e-03	8/28	H3F3A; H2AFZ; HIST1H4J; GTF2H5; CBX3; POLR2K; POLR2L; POLR2F
R-HSA-72165	mRNA Splicing - Minor Pathway	3.89	6.50e-06	1.40e-04	14/51	SNRPE; SF3B6; SNRPG; SF3B5; POLR2J; POLR2K; POLR2L; SF3B2; SNRPF; SNRPD1; POLR2I; SNRPD2; POLR2F; SNU13
R-HSA-72086	mRNA Capping	3.86	3.33e-03	4.86e-02	6/22	GTF2H5; POLR2J; POLR2K; POLR2L; POLR2I; POLR2F
R-HSA-167238	Pausing and recovery of Tat-mediated HIV elongation	3.67	2.10e-03	3.29e-02	7/27	POLR2J; TCEB1; POLR2K; POLR2L; TCEB2; POLR2I; POLR2F
R-HSA-167243	Tat-mediated HIV elongation arrest and recovery	3.67	2.10e-03	3.29e-02	7/27	POLR2J; TCEB1; POLR2K; POLR2L; TCEB2; POLR2I; POLR2F
R-HSA-72766	Translation	3.64	0.00e+00	0.00e+00	66/257	MRPL20; RPL11; RPS8; RPL5; MRPS21; RPS27; MRPL33; RPS27A; RPL37A; RPL32; RPL15; RPSA; SPCS1; RPL22L1; RPL9; RPS3A; RPL37; RPS23; RPS14; RPS18; RPL10A; RPS12; SEC61G; RPS4X; RPL36A; RPL39; SSR4; EIF4EBP1; RPS20; RPL7; RPL30; EIF3E; EIF3H; RPS6; SEC61B; RPL7A; MRPL41; EIF3F; RPL27A; RPS13; RPS3; CHCHD1; RPS24; RPS26; RPL6; RPLP0; RPL21; MRPL52; RPL36AL; SRP14; RPL4; RPS17; RPS2; RPS15A; RPL13; RPL26; RPL23A; RPL23; RPL19; RPL18A; RPS19; RPL18; RPL13A; EIF3L; RPL3; MRPS6
R-HSA-71291	Metabolism of amino acids and derivatives	3.52	0.00e+00	0.00e+00	52/209	RPL11; RPS8; RPL5; RPS27; RPS27A; RPL37A; RPL32; RPL15; RPSA; RPL22L1; RPL9; RPS3A; RPL37; RPS23; RPS14; RPS18; RPL10A; RPS12; SHFM1; HSD17B10; RPS4X; RPL36A; RPL39; RPS20; RPL7; RPL30; RPS6; RPL7A; RPL27A; RPS13; RPS3; RPS24; RPS26; RPL6; RPLP0; RPL21; RPL36AL; RPL4; RPS17; RPS2; RPS15A; RPL13; RPL26; RPL23A; RPL23; RPL19; OAZ1; RPL18A; RPS19; RPL18; RPL13A; RPL3
R-HSA-5663205	Infectious disease	3.50	0.00e+00	0.00e+00	68/275	RPL11; RPS8; RPL5; RPS27; RPS27A; RPL37A; RPL32; RPL15; RPSA; RPL22L1; RPL9; RPS3A; RPL37; RPS23; SKP1; RPS14; RPS18; RPL10A; RPS12; GTF2H5; PPIA; SHFM1; POLR2J; RPS4X; RPL36A; RPL39; RPS20; RPL7; TCEB1; RPL30; POLR2K; RPS6; RPL7A; POLR2L; RPL27A; RPS13; BANF1; RPS3; RPS24; RPS26; RPL6; RPLP0; RPL21; RPL36AL; CALM1; GTF2A2; RPL4; RPS17; RPS2; TCEB2; RPS15A; RPL13; RPL26; RPL23A; RPL23; RPL19; RPL18A; POLR2I; RPS19; CALM3; AP2S1; RPL18; RPL13A; CHMP2A; RANBP1; POLR2F; RPL3; RBX1
R-HSA-167169	HIV Transcription Elongation	3.43	1.63e-03	2.81e-02	8/33	GTF2H5; POLR2J; TCEB1; POLR2K; POLR2L; TCEB2; POLR2I; POLR2F
R-HSA-167200	Formation of HIV-1 elongation complex containing HIV-1 Tat	3.43	1.63e-03	2.81e-02	8/33	GTF2H5; POLR2J; TCEB1; POLR2K; POLR2L; TCEB2; POLR2I; POLR2F
R-HSA-167246	Tat-mediated elongation of the HIV-1 transcript	3.43	1.63e-03	2.81e-02	8/33	GTF2H5; POLR2J; TCEB1; POLR2K; POLR2L; TCEB2; POLR2I; POLR2F
R-HSA-167287	HIV elongation arrest and recovery	3.42	3.27e-03	4.86e-02	7/29	POLR2J; TCEB1; POLR2K; POLR2L; TCEB2; POLR2I; POLR2F
R-HSA-167290	Pausing and recovery of HIV elongation	3.42	3.27e-03	4.86e-02	7/29	POLR2J; TCEB1; POLR2K; POLR2L; TCEB2; POLR2I; POLR2F
R-HSA-6782210	Gap-filling DNA repair synthesis and ligation in TC-NER	3.27	1.23e-03	2.30e-02	9/39	RPS27A; GTF2H5; RPA3; POLR2J; POLR2K; POLR2L; POLR2I; POLR2F; RBX1
R-HSA-1592230	Mitochondrial biogenesis	3.25	5.95e-05	1.16e-03	14/61	MINOS1; ATP5G3; ATP5I; CYCS; ATP5J2; SSBP1; ATP5L; ATP5G2; CALM1; ATP5G1; ATP5H; ATP5E; CALM3; ATP5J
R-HSA-167152	Formation of HIV elongation complex in the absence of HIV Tat	3.24	2.44e-03	3.76e-02	8/35	GTF2H5; POLR2J; TCEB1; POLR2K; POLR2L; TCEB2; POLR2I; POLR2F
R-HSA-6782135	Dual incision in TC-NER	3.11	1.79e-03	3.02e-02	9/41	RPS27A; GTF2H5; RPA3; POLR2J; POLR2K; POLR2L; POLR2I; POLR2F; RBX1
R-HSA-422475	Axon guidance	2.63	1.28e-13	3.16e-12	61/328	RPL11; RPS8; RPL5; RPS27; ARPC5; RPS27A; RPL37A; RPL32; RPL15; RPSA; RPL22L1; RPL9; RPS3A; RPL37; RPS23; RPS14; RPS18; RPL10A; CD24; RPS12; SHFM1; RPS4X; RPL36A; RPL39; RPS20; RPL7; TCEB1; RPL30; RPS6; RPL7A; RPL27A; RPS13; CFL1; RPS3; RPS24; RPS26; MYL6; RPL6; RPLP0; RPL21; RPL36AL; RPL4; RPS17; RPS2; TCEB2; RPS15A; RPL13; PFN1; RPL26; RPL23A; RPL23; RPL19; MYL12B; RPL18A; PSENEN; RPS19; AP2S1; RPL18; RPL13A; RPL3; RBX1
R-HSA-1643685	Disease	2.23	2.17e-12	5.19e-11	73/464	RPL11; RPS8; PRDX1; RPL5; RPS27; RPS27A; RPL37A; RPL32; RPL15; RPSA; RPL22L1; RPL9; RPS3A; RPL37; RPS23; SKP1; RPS14; RPS18; RPL10A; RPS12; GTF2H5; PPIA; SHFM1; POLR2J; RPS4X; RPL36A; RPL39; RPS20; RPL7; TCEB1; RPL30; POLR2K; RPS6; RPL7A; POLR2L; RPL27A; RPS13; BANF1; RPS3; RPS24; RPS26; RPL6; PEBP1; RPLP0; RPL21; RPL36AL; CALM1; GTF2A2; RPL4; RPS17; RPS2; TCEB2; RPS15A; RPL13; RPL26; RPL23A; RPL23; RPL19; DCXR; PRDX2; RPL18A; PSENEN; POLR2I; RPS19; CALM3; AP2S1; RPL18; RPL13A; CHMP2A; RANBP1; POLR2F; RPL3; RBX1
R-HSA-1266738	Developmental Biology	2.19	2.26e-11	5.25e-10	69/445	RPL11; RPS8; RPL5; RPS27; ARPC5; H3F3A; RPS27A; RPL37A; RPL32; RPL15; RPSA; RPL22L1; RPL9; H2AFZ; RPS3A; RPL37; RPS23; RPS14; HIST1H4J; RPS18; RPL10A; CD24; RPS12; SHFM1; POLR2J; RPS4X; RPL36A; RPL39; RPS20; RPL7; TCEB1; RPL30; POLR2K; RPS6; RPL7A; POLR2L; RPL27A; RPS13; CFL1; RPS3; RPS24; RPS26; MYL6; RPL6; RPLP0; RPL21; RPL36AL; RPL4; RPS17; RPS2; TCEB2; RPS15A; RPL13; PFN1; RPL26; RPL23A; RPL23; RPL19; MYL12B; RPL18A; PSENEN; POLR2I; RPS19; AP2S1; RPL18; RPL13A; POLR2F; RPL3; RBX1
R-HSA-3700989	Transcriptional Regulation by TP53	2.11	2.88e-05	5.76e-04	32/215	PRDX1; LAMTOR5; LAMTOR2; COX20; RPS27A; COX5B; COX7C; GTF2H5; RPA3; NDUFA4; CYCS; LAMTOR4; POLR2J; COX7B; TCEB1; COX6C; POLR2K; YWHAZ; TXN; POLR2L; COX8A; PRDX5; COX14; COX16; COX5A; TCEB2; COX4I1; PRDX2; COX6B1; POLR2I; POLR2F; MT-CO1

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ASH1L : 13 significant Reactome pathways

GeneSet	description	enrichRatio	pValue	FDR	GeneRatio	geneSymbols
R-HSA-8876725	Protein methylation	7.52	2.85e-04	0.02454	5/12	EEF1A1; CALM1; EEF2; ETFB
R-HSA-5339562	Uptake and actions of bacterial toxins	6.37	1.98e-04	0.02387	6/17	HSP90AB1; STX1A; SYT1; CALM1; EEF2
R-HSA-500792	GPCR ligand binding	6.02	8.01e-06	0.00345	9/27	GNG5; AGT; GNG4; SST; GRM4; FZD1; GAL; SSTR2; PTH2
R-HSA-5578775	Ion homeostasis	5.50	1.65e-04	0.02364	7/23	ATP1B1; RYR2; CAMK2B; SRI; CALM1; FXYD7
R-HSA-2672351	Stimuli-sensing channels	5.27	2.22e-04	0.02387	7/24	RYR2; ASIC4; SRI; ASIC1; CALM1; TTYH2
R-HSA-5576891	Cardiac conduction	4.64	8.19e-05	0.01410	9/35	ATP1B1; RYR2; SCN3A; CAMK2B; SRI; AKAP9; CALM1; FXYD7
R-HSA-112314	Neurotransmitter receptors and postsynaptic signal transmission	4.05	5.17e-05	0.01112	11/49	GNG5; GNG4; CHRNA1; GNAI2; AP2M1; GRIA2; CAMK2B; NEFL; CALM1; KCNJ6
R-HSA-397014	Muscle contraction	3.28	7.06e-04	0.04808	10/55	ATP1B1; RYR2; SCN3A; CAMK2B; SRI; AKAP9; CALD1; CALM1; FXYD7
R-HSA-112315	Transmission across Chemical Synapses	3.26	3.55e-05	0.01020	15/83	GNG5; GNG4; CHRNA1; GNAI2; AP2M1; GRIA2; CAMK2B; STX1A; NEFL; SYT1; CALM1; CACNA1A; RAB3A; KCNJ6
R-HSA-112316	Neuronal System	3.21	4.06e-06	0.00345	19/107	PTPRF; GNG5; GNG4; NRXN1; CHRNA1; GNAI2; AP2M1; GRIA2; CAMK2B; STX1A; NEFL; SYT7; SYT1; CALM1; CACNA1A; RAB3A; HOMER3; KCNJ6
R-HSA-418594	G alpha (i) signalling events	3.06	7.26e-04	0.04808	11/65	GNG5; RGS16; AGT; GNG4; GNAI2; SST; GRM4; GAL; CALM1; SSTR2
R-HSA-372790	Signaling by GPCR	2.56	2.59e-04	0.02454	17/120	GNG5; RHOC; RGS16; AGT; GNG4; REEP1; GNAI2; ABHD6; SST; GRM4; FZD1; GAL; CALM1; SSTR2; PREX1; PTH2
R-HSA-388396	GPCR downstream signalling	2.49	5.37e-04	0.04201	16/116	GNG5; RHOC; RGS16; AGT; GNG4; REEP1; GNAI2; ABHD6; SST; GRM4; GAL; CALM1; SSTR2; PREX1; PTH2

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CHD2 : 48 significant Reactome pathways

GeneSet	description	enrichRatio	pValue	FDR	GeneRatio	geneSymbols
R-HSA-156902	Peptide chain elongation	5.82	0.00e+00	0.00e+00	66/84	RPL22; RPL11; RPS8; RPL5; RPS27; RPS27A; RPL31; RPL37A; RPL32; RPL15; RPSA; RPL14; RPL24; RPL22L1; RPL35A; RPL9; RPL34; RPS3A; RPL37; RPS23; RPS14; RPS10; EEF1A1; RPS12; RPS4X; RPL36A; RPL39; RPL10; RPS20; RPL7; RPL30; RPL8; RPS6; RPL7A; RPL27A; RPS13; RPS3; RPS24; RPL41; RPL6; RPLP0; RPL21; RPS29; RPL36AL; RPL4; RPLP1; RPS17; RPS15A; RPL13; RPL26; RPL23A; RPL23; RPL19; RPL27; RPL38; RPL17; RPS15; EEF2; RPS28; RPL18A; RPS16; RPS19; RPL18; RPL13A; RPS5; RPL3
R-HSA-156842	Eukaryotic Translation Elongation	5.77	0.00e+00	0.00e+00	67/86	RPL22; RPL11; RPS8; RPL5; RPS27; RPS27A; RPL31; EEF1B2; RPL37A; RPL32; RPL15; RPSA; RPL14; RPL24; RPL22L1; RPL35A; RPL9; RPL34; RPS3A; RPL37; RPS23; RPS14; RPS10; EEF1A1; RPS12; RPS4X; RPL36A; RPL39; RPL10; RPS20; RPL7; RPL30; RPL8; RPS6; RPL7A; RPL27A; RPS13; RPS3; RPS24; RPL41; RPL6; RPLP0; RPL21; RPS29; RPL36AL; RPL4; RPLP1; RPS17; RPS15A; RPL13; RPL26; RPL23A; RPL23; RPL19; RPL27; RPL38; RPL17; RPS15; EEF2; RPS28; RPL18A; RPS16; RPS19; RPL18; RPL13A; RPS5; RPL3
R-HSA-192823	Viral mRNA Translation	5.71	0.00e+00	0.00e+00	64/83	RPL22; RPL11; RPS8; RPL5; RPS27; RPS27A; RPL31; RPL37A; RPL32; RPL15; RPSA; RPL14; RPL24; RPL22L1; RPL35A; RPL9; RPL34; RPS3A; RPL37; RPS23; RPS14; RPS10; RPS12; RPS4X; RPL36A; RPL39; RPL10; RPS20; RPL7; RPL30; RPL8; RPS6; RPL7A; RPL27A; RPS13; RPS3; RPS24; RPL41; RPL6; RPLP0; RPL21; RPS29; RPL36AL; RPL4; RPLP1; RPS17; RPS15A; RPL13; RPL26; RPL23A; RPL23; RPL19; RPL27; RPL38; RPL17; RPS15; RPS28; RPL18A; RPS16; RPS19; RPL18; RPL13A; RPS5; RPL3
R-HSA-72764	Eukaryotic Translation Termination	5.60	0.00e+00	0.00e+00	65/86	RPL22; RPL11; RPS8; RPL5; RPS27; RPS27A; RPL31; RPL37A; RPL32; RPL15; RPSA; RPL14; RPL24; RPL22L1; RPL35A; RPL9; RPL34; RPS3A; RPL37; RPS23; RPS14; RPS10; RPS12; RPS4X; RPL36A; RPL39; RPL10; RPS20; RPL7; RPL30; RPL8; RPS6; RPL7A; RPL27A; RPS13; TRMT112; RPS3; RPS24; RPL41; RPL6; RPLP0; RPL21; RPS29; RPL36AL; RPL4; RPLP1; RPS17; RPS15A; RPL13; RPL26; RPL23A; RPL23; RPL19; RPL27; RPL38; RPL17; RPS15; RPS28; RPL18A; RPS16; RPS19; RPL18; RPL13A; RPS5; RPL3
R-HSA-2408557	Selenocysteine synthesis	5.57	0.00e+00	0.00e+00	64/85	RPL22; RPL11; RPS8; RPL5; RPS27; RPS27A; RPL31; RPL37A; RPL32; RPL15; RPSA; RPL14; RPL24; RPL22L1; RPL35A; RPL9; RPL34; RPS3A; RPL37; RPS23; RPS14; RPS10; RPS12; RPS4X; RPL36A; RPL39; RPL10; RPS20; RPL7; RPL30; RPL8; RPS6; RPL7A; RPL27A; RPS13; RPS3; RPS24; RPL41; RPL6; RPLP0; RPL21; RPS29; RPL36AL; RPL4; RPLP1; RPS17; RPS15A; RPL13; RPL26; RPL23A; RPL23; RPL19; RPL27; RPL38; RPL17; RPS15; RPS28; RPL18A; RPS16; RPS19; RPL18; RPL13A; RPS5; RPL3
R-HSA-975956	Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)	5.38	0.00e+00	0.00e+00	64/88	RPL22; RPL11; RPS8; RPL5; RPS27; RPS27A; RPL31; RPL37A; RPL32; RPL15; RPSA; RPL14; RPL24; RPL22L1; RPL35A; RPL9; RPL34; RPS3A; RPL37; RPS23; RPS14; RPS10; RPS12; RPS4X; RPL36A; RPL39; RPL10; RPS20; RPL7; RPL30; RPL8; RPS6; RPL7A; RPL27A; RPS13; RPS3; RPS24; RPL41; RPL6; RPLP0; RPL21; RPS29; RPL36AL; RPL4; RPLP1; RPS17; RPS15A; RPL13; RPL26; RPL23A; RPL23; RPL19; RPL27; RPL38; RPL17; RPS15; RPS28; RPL18A; RPS16; RPS19; RPL18; RPL13A; RPS5; RPL3
R-HSA-72689	Formation of a pool of free 40S subunits	5.38	0.00e+00	0.00e+00	69/95	RPL22; RPL11; RPS8; RPL5; RPS27; RPS27A; RPL31; RPL37A; RPL32; RPL15; RPSA; RPL14; RPL24; RPL22L1; RPL35A; RPL9; RPL34; RPS3A; RPL37; RPS23; RPS14; RPS10; RPS12; RPS4X; RPL36A; RPL39; RPL10; RPS20; RPL7; RPL30; EIF3E; EIF3H; RPL8; RPS6; RPL7A; EIF3F; RPL27A; RPS13; RPS3; RPS24; RPL41; RPL6; RPLP0; RPL21; RPS29; RPL36AL; EIF3J; RPL4; RPLP1; RPS17; RPS15A; RPL13; RPL26; RPL23A; RPL23; RPL19; RPL27; RPL38; RPL17; RPS15; RPS28; RPL18A; RPS16; RPS19; RPL18; RPL13A; RPS5; EIF3L; RPL3
R-HSA-1799339	SRP-dependent cotranslational protein targeting to membrane	4.98	0.00e+00	0.00e+00	70/104	RPL22; RPL11; RPS8; RPL5; RPS27; RPS27A; RPL31; RPL37A; RPL32; RPL15; RPSA; RPL14; SPCS1; RPL24; RPL22L1; RPL35A; RPL9; RPL34; RPS3A; RPL37; RPS23; RPS14; RPS10; RPS12; SEC61G; RPS4X; RPL36A; RPL39; SSR4; RPL10; RPS20; RPL7; RPL30; RPL8; RPS6; SEC61B; RPL7A; RPL27A; RPS13; RPS3; RPS24; RPL41; RPL6; RPLP0; RPL21; RPS29; RPL36AL; SRP14; RPL4; RPLP1; RPS17; RPS15A; RPL13; RPL26; RPL23A; RPL23; RPL19; RPL27; RPL38; RPL17; RPN2; RPS15; RPS28; RPL18A; RPS16; RPS19; RPL18; RPL13A; RPS5; RPL3
R-HSA-156827	L13a-mediated translational silencing of Ceruloplasmin expression	4.87	0.00e+00	0.00e+00	69/105	RPL22; RPL11; RPS8; RPL5; RPS27; RPS27A; RPL31; RPL37A; RPL32; RPL15; RPSA; RPL14; RPL24; RPL22L1; RPL35A; RPL9; RPL34; RPS3A; RPL37; RPS23; RPS14; RPS10; RPS12; RPS4X; RPL36A; RPL39; RPL10; RPS20; RPL7; RPL30; EIF3E; EIF3H; RPL8; RPS6; RPL7A; EIF3F; RPL27A; RPS13; RPS3; RPS24; RPL41; RPL6; RPLP0; RPL21; RPS29; RPL36AL; EIF3J; RPL4; RPLP1; RPS17; RPS15A; RPL13; RPL26; RPL23A; RPL23; RPL19; RPL27; RPL38; RPL17; RPS15; RPS28; RPL18A; RPS16; RPS19; RPL18; RPL13A; RPS5; EIF3L; RPL3
R-HSA-2408522	Selenoamino acid metabolism	4.86	0.00e+00	0.00e+00	65/99	RPL22; RPL11; RPS8; RPL5; RPS27; RPS27A; RPL31; RPL37A; RPL32; RPL15; RPSA; RPL14; RPL24; RPL22L1; RPL35A; RPL9; PAPSS1; RPL34; RPS3A; RPL37; RPS23; RPS14; RPS10; RPS12; RPS4X; RPL36A; RPL39; RPL10; RPS20; RPL7; RPL30; RPL8; RPS6; RPL7A; RPL27A; RPS13; RPS3; RPS24; RPL41; RPL6; RPLP0; RPL21; RPS29; RPL36AL; RPL4; RPLP1; RPS17; RPS15A; RPL13; RPL26; RPL23A; RPL23; RPL19; RPL27; RPL38; RPL17; RPS15; RPS28; RPL18A; RPS16; RPS19; RPL18; RPL13A; RPS5; RPL3
R-HSA-72706	GTP hydrolysis and joining of the 60S ribosomal subunit	4.82	0.00e+00	0.00e+00	69/106	RPL22; RPL11; RPS8; RPL5; RPS27; RPS27A; RPL31; RPL37A; RPL32; RPL15; RPSA; RPL14; RPL24; RPL22L1; RPL35A; RPL9; RPL34; RPS3A; RPL37; RPS23; RPS14; RPS10; RPS12; RPS4X; RPL36A; RPL39; RPL10; RPS20; RPL7; RPL30; EIF3E; EIF3H; RPL8; RPS6; RPL7A; EIF3F; RPL27A; RPS13; RPS3; RPS24; RPL41; RPL6; RPLP0; RPL21; RPS29; RPL36AL; EIF3J; RPL4; RPLP1; RPS17; RPS15A; RPL13; RPL26; RPL23A; RPL23; RPL19; RPL27; RPL38; RPL17; RPS15; RPS28; RPL18A; RPS16; RPS19; RPL18; RPL13A; RPS5; EIF3L; RPL3
R-HSA-927802	Nonsense-Mediated Decay (NMD)	4.58	0.00e+00	0.00e+00	65/105	RPL22; RPL11; RPS8; RPL5; RPS27; RPS27A; RPL31; RPL37A; RPL32; RPL15; RPSA; RPL14; RPL24; RPL22L1; RPL35A; RPL9; RPL34; RPS3A; RPL37; RPS23; RPS14; RPS10; RPS12; RPS4X; RPL36A; RPL39; RPL10; RPS20; RPL7; RPL30; RPL8; RPS6; RPL7A; RPL27A; RPS13; RPS3; RPS24; RPL41; RPL6; RPLP0; RPL21; RPS29; RPL36AL; RPL4; RPLP1; RPS17; RPS15A; RPL13; RPL26; RPL23A; RPL23; RPL19; RPL27; RPL38; EIF4A3; RPL17; RPS15; RPS28; RPL18A; RPS16; RPS19; RPL18; RPL13A; RPS5; RPL3
R-HSA-975957	Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)	4.58	0.00e+00	0.00e+00	65/105	RPL22; RPL11; RPS8; RPL5; RPS27; RPS27A; RPL31; RPL37A; RPL32; RPL15; RPSA; RPL14; RPL24; RPL22L1; RPL35A; RPL9; RPL34; RPS3A; RPL37; RPS23; RPS14; RPS10; RPS12; RPS4X; RPL36A; RPL39; RPL10; RPS20; RPL7; RPL30; RPL8; RPS6; RPL7A; RPL27A; RPS13; RPS3; RPS24; RPL41; RPL6; RPLP0; RPL21; RPS29; RPL36AL; RPL4; RPLP1; RPS17; RPS15A; RPL13; RPL26; RPL23A; RPL23; RPL19; RPL27; RPL38; EIF4A3; RPL17; RPS15; RPS28; RPL18A; RPS16; RPS19; RPL18; RPL13A; RPS5; RPL3
R-HSA-72613	Eukaryotic Translation Initiation	4.52	0.00e+00	0.00e+00	69/113	RPL22; RPL11; RPS8; RPL5; RPS27; RPS27A; RPL31; RPL37A; RPL32; RPL15; RPSA; RPL14; RPL24; RPL22L1; RPL35A; RPL9; RPL34; RPS3A; RPL37; RPS23; RPS14; RPS10; RPS12; RPS4X; RPL36A; RPL39; RPL10; RPS20; RPL7; RPL30; EIF3E; EIF3H; RPL8; RPS6; RPL7A; EIF3F; RPL27A; RPS13; RPS3; RPS24; RPL41; RPL6; RPLP0; RPL21; RPS29; RPL36AL; EIF3J; RPL4; RPLP1; RPS17; RPS15A; RPL13; RPL26; RPL23A; RPL23; RPL19; RPL27; RPL38; RPL17; RPS15; RPS28; RPL18A; RPS16; RPS19; RPL18; RPL13A; RPS5; EIF3L; RPL3
R-HSA-72737	Cap-dependent Translation Initiation	4.52	0.00e+00	0.00e+00	69/113	RPL22; RPL11; RPS8; RPL5; RPS27; RPS27A; RPL31; RPL37A; RPL32; RPL15; RPSA; RPL14; RPL24; RPL22L1; RPL35A; RPL9; RPL34; RPS3A; RPL37; RPS23; RPS14; RPS10; RPS12; RPS4X; RPL36A; RPL39; RPL10; RPS20; RPL7; RPL30; EIF3E; EIF3H; RPL8; RPS6; RPL7A; EIF3F; RPL27A; RPS13; RPS3; RPS24; RPL41; RPL6; RPLP0; RPL21; RPS29; RPL36AL; EIF3J; RPL4; RPLP1; RPS17; RPS15A; RPL13; RPL26; RPL23A; RPL23; RPL19; RPL27; RPL38; RPL17; RPS15; RPS28; RPL18A; RPS16; RPS19; RPL18; RPL13A; RPS5; EIF3L; RPL3
R-HSA-168273	Influenza Viral RNA Transcription and Replication	4.46	0.00e+00	0.00e+00	68/113	RPL22; RPL11; RPS8; RPL5; RPS27; RPS27A; RPL31; RPL37A; RPL32; RPL15; RPSA; RPL14; RPL24; RPL22L1; RPL35A; RPL9; RPL34; RPS3A; RPL37; RPS23; RPS14; RPS10; RPS12; RPS4X; RPL36A; RPL39; RPL10; RPS20; RPL7; RPL30; POLR2K; RPL8; RPS6; RPL7A; POLR2L; RPL27A; RPS13; RPS3; RPS24; RPL41; RPL6; RPLP0; RPL21; RPS29; RPL36AL; HSP90AA1; RPL4; RPLP1; RPS17; RPS15A; RPL13; RPL26; RPL23A; RPL23; RPL19; RPL27; RPL38; RPL17; RPS15; RPS28; RPL18A; RPS16; RPS19; RPL18; RPL13A; RPS5; POLR2F; RPL3
R-HSA-445355	Smooth Muscle Contraction	4.36	1.48e-05	3.10e-04	10/17	CALM2; ANXA6; CALD1; VCL; MYL6B; MYL6; CALM1; MYL12A; MYL12B; CALM3
R-HSA-72695	Formation of the ternary complex, and subsequently, the 43S complex	4.32	2.67e-13	7.93e-12	28/48	RPS8; RPS27; RPS27A; RPSA; RPS3A; RPS23; RPS14; RPS10; RPS12; RPS4X; RPS20; EIF3E; EIF3H; RPS6; EIF3F; RPS13; RPS3; RPS24; RPS29; EIF3J; RPS17; RPS15A; RPS15; RPS28; RPS16; RPS19; RPS5; EIF3L
R-HSA-8876725	Protein methylation	4.32	3.37e-04	6.59e-03	7/12	CALM2; EEF1A1; HSPA8; CALM1; EEF2; CALM3; ETFB
R-HSA-5576892	Phase 0 - rapid depolarisation	4.32	3.37e-04	6.59e-03	7/12	CALM2; SCN3A; SCN9A; CAMK2B; CACNB3; CALM1; CALM3
R-HSA-168255	Influenza Life Cycle	4.28	0.00e+00	0.00e+00	70/121	RPL22; RPL11; RPS8; RPL5; RPS27; RPS27A; RPL31; RPL37A; RPL32; RPL15; RPSA; RPL14; RPL24; RPL22L1; RPL35A; RPL9; RPL34; RPS3A; RPL37; RPS23; RPS14; CANX; RPS10; RPS12; RPS4X; RPL36A; RPL39; RPL10; RPS20; RPL7; RPL30; POLR2K; RPL8; RPS6; RPL7A; POLR2L; RPL27A; RPS13; RPS3; RPS24; RPL41; RPL6; RPLP0; RPL21; RPS29; RPL36AL; HSP90AA1; RPL4; RPLP1; RPS17; RPS15A; RPL13; RPL26; RPL23A; RPL23; RPL19; RPL27; RPL38; RPL17; RPS15; RPS28; CALR; RPL18A; RPS16; RPS19; RPL18; RPL13A; RPS5; POLR2F; RPL3
R-HSA-168254	Influenza Infection	4.05	0.00e+00	0.00e+00	70/128	RPL22; RPL11; RPS8; RPL5; RPS27; RPS27A; RPL31; RPL37A; RPL32; RPL15; RPSA; RPL14; RPL24; RPL22L1; RPL35A; RPL9; RPL34; RPS3A; RPL37; RPS23; RPS14; CANX; RPS10; RPS12; RPS4X; RPL36A; RPL39; RPL10; RPS20; RPL7; RPL30; POLR2K; RPL8; RPS6; RPL7A; POLR2L; RPL27A; RPS13; RPS3; RPS24; RPL41; RPL6; RPLP0; RPL21; RPS29; RPL36AL; HSP90AA1; RPL4; RPLP1; RPS17; RPS15A; RPL13; RPL26; RPL23A; RPL23; RPL19; RPL27; RPL38; RPL17; RPS15; RPS28; CALR; RPL18A; RPS16; RPS19; RPL18; RPL13A; RPS5; POLR2F; RPL3
R-HSA-983170	Antigen Presentation: Folding, assembly and peptide loading of class I MHC	4.04	1.49e-03	2.62e-02	6/11	CANX; HLA-A; HSPA5; PDIA3; B2M; CALR
R-HSA-72649	Translation initiation complex formation	3.77	2.42e-11	6.50e-10	28/55	RPS8; RPS27; RPS27A; RPSA; RPS3A; RPS23; RPS14; RPS10; RPS12; RPS4X; RPS20; EIF3E; EIF3H; RPS6; EIF3F; RPS13; RPS3; RPS24; RPS29; EIF3J; RPS17; RPS15A; RPS15; RPS28; RPS16; RPS19; RPS5; EIF3L
R-HSA-72702	Ribosomal scanning and start codon recognition	3.77	2.42e-11	6.50e-10	28/55	RPS8; RPS27; RPS27A; RPSA; RPS3A; RPS23; RPS14; RPS10; RPS12; RPS4X; RPS20; EIF3E; EIF3H; RPS6; EIF3F; RPS13; RPS3; RPS24; RPS29; EIF3J; RPS17; RPS15A; RPS15; RPS28; RPS16; RPS19; RPS5; EIF3L
R-HSA-72662	Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S	3.70	4.23e-11	1.10e-09	28/56	RPS8; RPS27; RPS27A; RPSA; RPS3A; RPS23; RPS14; RPS10; RPS12; RPS4X; RPS20; EIF3E; EIF3H; RPS6; EIF3F; RPS13; RPS3; RPS24; RPS29; EIF3J; RPS17; RPS15A; RPS15; RPS28; RPS16; RPS19; RPS5; EIF3L
R-HSA-9010553	Regulation of expression of SLITs and ROBOs	3.58	0.00e+00	0.00e+00	72/149	RPL22; RPL11; RPS8; RPL5; RPS27; LHX9; RPS27A; RPL31; RPL37A; RPL32; RPL15; RPSA; RPL14; ROBO1; RPL24; RPL22L1; RPL35A; RPL9; RPL34; RPS3A; RPL37; RPS23; RPS14; RPS10; RPS12; SHFM1; RPS4X; RPL36A; RPL39; RPL10; RPS20; RPL7; TCEB1; RPL30; RPL8; RPS6; RPL7A; RPL27A; RPS13; RPS3; RPS24; RPL41; RPL6; RPLP0; RPL21; RPS29; RPL36AL; RPL4; RPLP1; RPS17; TCEB2; RPS15A; RPL13; RPL26; RPL23A; PSMB3; RPL23; RPL19; RPL27; RPL38; EIF4A3; RPL17; PSMA7; RPS15; RPS28; RPL18A; RPS16; RPS19; RPL18; RPL13A; RPS5; RPL3
R-HSA-500792	GPCR ligand binding	3.56	1.40e-05	3.01e-04	13/27	GNG5; AGT; GNG4; SST; GRM4; FZD1; GABBR2; GAL; NMB; SSTR2; GNAS; GNG8; PTH2
R-HSA-5578775	Ion homeostasis	3.54	7.12e-05	1.46e-03	11/23	ATP1B1; RYR2; FKBP1B; CALM2; CAMK2B; SRI; FXYD6; ATP2B1; CALM1; FXYD7; CALM3
R-HSA-6799198	Complex I biogenesis	3.42	8.54e-09	1.94e-07	24/52	NDUFS5; NDUFAF3; NDUFB4; NDUFA2; NDUFA5; NDUFB2; NDUFB11; NDUFA1; NDUFB9; NDUFS8; NDUFC2; NDUFB8; NDUFB10; NDUFAB1; NDUFA11; NDUFA7; NDUFB7; NDUFA13; NDUFA3; NDUFA6; MT-ND1; MT-ND3; MT-ND4; MT-ND6
R-HSA-5576891	Cardiac conduction	3.38	3.29e-06	7.27e-05	16/35	ATP1B1; RYR2; FKBP1B; CALM2; SCN3A; SCN9A; CAMK2B; SRI; AKAP9; FXYD6; KCNIP2; CACNB3; ATP2B1; CALM1; FXYD7; CALM3
R-HSA-397014	Muscle contraction	3.37	6.13e-09	1.43e-07	25/55	ATP1B1; TNNI1; RYR2; FKBP1B; CALM2; SCN3A; SCN9A; MYL1; ANXA6; CAMK2B; SRI; AKAP9; CALD1; FXYD6; VCL; KCNIP2; CACNB3; MYL6B; MYL6; ATP2B1; CALM1; MYL12A; MYL12B; FXYD7; CALM3
R-HSA-163210	Formation of ATP by chemiosmotic coupling	3.29	1.32e-03	2.37e-02	8/18	ATP5G3; ATP5I; ATP5J2; ATP5B; ATP5G1; ATP5H; ATP5A1; ATP5J
R-HSA-376176	Signaling by ROBO receptors	3.16	0.00e+00	0.00e+00	76/178	RPL22; RPL11; RPS8; RPL5; RPS27; LHX9; RPS27A; RPL31; RPL37A; RPL32; RPL15; RPSA; RPL14; ROBO1; RPL24; RPL22L1; RPL35A; RPL9; RPL34; RPS3A; RPL37; RPS23; RPS14; CAP2; RPS10; RPS12; SHFM1; RPS4X; RPL36A; RPL39; RPL10; RPS20; RPL7; TCEB1; RPL30; RPL8; RPS6; RPL7A; RPL27A; RPS13; RPS3; RPS24; RPL41; SRGAP1; RPL6; RPLP0; RPL21; RPS29; RPL36AL; RPL4; RPLP1; RPS17; TCEB2; RPS15A; RPL13; PFN1; RPL26; RPL23A; PSMB3; RPL23; RPL19; RPL27; RPL38; EIF4A3; RPL17; DCC; PSMA7; RPS15; RPS28; RPL18A; RPS16; RPS19; RPL18; RPL13A; RPS5; RPL3
R-HSA-8868773	rRNA processing in the nucleus and cytosol	3.15	0.00e+00	0.00e+00	68/160	RPL22; RPL11; RPS8; RPL5; RPS27; RPS27A; RPL31; RPL37A; RPL32; RPL15; RPSA; RPL14; RPL24; RPL22L1; RPL35A; RPL9; RPL34; RPS3A; RPL37; RPS23; RPS14; NHP2; RPS10; RPS12; RPS4X; RPL36A; RPL39; RPL10; RPS20; RPL7; RPL30; RPL8; RPS6; RPL7A; RPL27A; RPS13; TRMT112; RPS3; DDX21; RPS24; RPL41; RPL6; RPLP0; RPL21; RPS29; RPL36AL; NOP10; RPL4; RPLP1; RPS17; RPS15A; RPL13; RPL26; RPL23A; RPL23; RPL19; RPL27; RPL38; RPL17; RPS15; RPS28; RPL18A; RPS16; RPS19; RPL18; RPL13A; RPS5; RPL3
R-HSA-6791226	Major pathway of rRNA processing in the nucleolus and cytosol	3.12	0.00e+00	0.00e+00	65/154	RPL22; RPL11; RPS8; RPL5; RPS27; RPS27A; RPL31; RPL37A; RPL32; RPL15; RPSA; RPL14; RPL24; RPL22L1; RPL35A; RPL9; RPL34; RPS3A; RPL37; RPS23; RPS14; RPS10; RPS12; RPS4X; RPL36A; RPL39; RPL10; RPS20; RPL7; RPL30; RPL8; RPS6; RPL7A; RPL27A; RPS13; RPS3; DDX21; RPS24; RPL41; RPL6; RPLP0; RPL21; RPS29; RPL36AL; RPL4; RPLP1; RPS17; RPS15A; RPL13; RPL26; RPL23A; RPL23; RPL19; RPL27; RPL38; RPL17; RPS15; RPS28; RPL18A; RPS16; RPS19; RPL18; RPL13A; RPS5; RPL3
R-HSA-72312	rRNA processing	3.11	0.00e+00	0.00e+00	69/164	RPL22; RPL11; RPS8; RPL5; RPS27; RPS27A; RPL31; RPL37A; RPL32; RPL15; RPSA; RPL14; RPL24; RPL22L1; RPL35A; RPL9; RPL34; RPS3A; RPL37; RPS23; RPS14; NHP2; RPS10; RPS12; HSD17B10; RPS4X; RPL36A; RPL39; RPL10; RPS20; RPL7; RPL30; RPL8; RPS6; RPL7A; RPL27A; RPS13; TRMT112; RPS3; DDX21; RPS24; RPL41; RPL6; RPLP0; RPL21; RPS29; RPL36AL; NOP10; RPL4; RPLP1; RPS17; RPS15A; RPL13; RPL26; RPL23A; RPL23; RPL19; RPL27; RPL38; RPL17; RPS15; RPS28; RPL18A; RPS16; RPS19; RPL18; RPL13A; RPS5; RPL3
R-HSA-163200	Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.	2.86	8.16e-12	2.34e-10	44/114	NDUFS5; COX5B; ATP5G3; NDUFAF3; NDUFB4; ATP5I; UQCRQ; NDUFA2; NDUFA4; CYCS; ATP5J2; NDUFA5; NDUFB2; NDUFB11; COX7B; NDUFA1; UQCRB; COX6C; NDUFB9; COX8A; NDUFS8; NDUFC2; NDUFB8; ATP5B; COX5A; NDUFB10; NDUFAB1; ATP5G1; ATP5H; ATP5A1; UQCR11; NDUFA11; NDUFA7; NDUFB7; NDUFA13; COX6B1; ETFB; NDUFA3; NDUFA6; ATP5J; MT-ND1; MT-ND3; MT-ND4; MT-ND6
R-HSA-611105	Respiratory electron transport	2.81	1.32e-09	3.24e-08	36/95	NDUFS5; COX5B; NDUFAF3; NDUFB4; UQCRQ; NDUFA2; NDUFA4; CYCS; NDUFA5; NDUFB2; NDUFB11; COX7B; NDUFA1; UQCRB; COX6C; NDUFB9; COX8A; NDUFS8; NDUFC2; NDUFB8; COX5A; NDUFB10; NDUFAB1; UQCR11; NDUFA11; NDUFA7; NDUFB7; NDUFA13; COX6B1; ETFB; NDUFA3; NDUFA6; MT-ND1; MT-ND3; MT-ND4; MT-ND6
R-HSA-936837	Ion transport by P-type ATPases	2.78	2.76e-03	4.66e-02	9/24	ATP1B1; CALM2; CAMK2B; SRI; FXYD6; ATP2B1; CALM1; FXYD7; CALM3
R-HSA-418346	Platelet homeostasis	2.71	1.18e-03	2.16e-02	11/30	GNG5; GNG4; CALM2; PRKG2; SRI; ATP2B1; CALM1; GNAS; CALM3; GNG8; PDE9A
R-HSA-71291	Metabolism of amino acids and derivatives	2.69	0.00e+00	0.00e+00	76/209	RPL22; RPL11; RPS8; RPL5; PHGDH; RPS27; RPS27A; RPL31; RPL37A; RPL32; RPL15; RPSA; RPL14; RPL24; RPL22L1; RPL35A; RPL9; PAPSS1; RPL34; RPS3A; RPL37; RPS23; CDO1; RPS14; RPS10; RPS12; SHFM1; SAT1; HSD17B10; RPS4X; RPL36A; RPL39; RPL10; RPS20; RPL7; RPL30; RPL8; RPS6; RPL7A; RPL27A; RPS13; RPS3; RPS24; BCAT1; RPL41; RPL6; RPLP0; PXMP2; RPL21; RPS29; RPL36AL; RPL4; RPLP1; RPS17; RPS15A; NDUFAB1; RPL13; RPL26; RPL23A; PSMB3; RPL23; RPL19; RPL27; RPL38; RPL17; PSMA7; RPS15; OAZ1; RPS28; RPL18A; RPS16; RPS19; RPL18; RPL13A; RPS5; RPL3
R-HSA-5663205	Infectious disease	2.42	0.00e+00	0.00e+00	90/275	RPL22; RPL11; RPS8; RPL5; RPS27; CALM2; RPS27A; RPL31; RPL37A; RPL32; RPL15; RPSA; RPL14; RPL24; RPL22L1; AP2M1; RPL35A; RPL9; RPL34; RPS3A; RPL37; RPS23; SKP1; RPS14; CANX; HMGA1; RPS10; RPS12; GTF2H5; STX1A; SHFM1; RPS4X; RPL36A; RPL39; RPL10; RPS20; RPL7; TCEB1; RPL30; POLR2K; RPL8; RPS6; RPL7A; POLR2L; RPL27A; RPS13; BANF1; RPS3; RPS24; RPL41; RPL6; RPLP0; RPL21; RPS29; RPL36AL; CALM1; HSP90AA1; B2M; GTF2A2; RPL4; RPLP1; RPS17; TCEB2; RPS15A; RPL13; VAMP2; RPL26; RPL23A; PSMB3; RPL23; RPL19; RPL27; RPL38; RPL17; PSMA7; RPS15; EEF2; RPS28; CALR; RPL18A; RPS16; RPS19; CALM3; RPL18; RPL13A; RPS5; CHMP2A; RANBP1; POLR2F; RPL3
R-HSA-72766	Translation	2.42	1.11e-16	3.54e-15	84/257	MRPL20; RPL22; RPL11; RPS8; RPL5; MRPS21; RPS27; MRPL33; RPS27A; RPL31; EEF1B2; RPL37A; RPL32; RPL15; RPSA; RPL14; SPCS1; RPL24; RPL22L1; RPL35A; RPL9; RPL34; RPS3A; RPL37; RPS23; RPS14; RPS10; MRPL14; EEF1A1; RPS12; SEC61G; RPS4X; RPL36A; RPL39; SSR4; RPL10; RPS20; RPL7; RPL30; EIF3E; EIF3H; RPL8; RPS6; SEC61B; RPL7A; EIF3F; RPL27A; RPS13; TRMT112; RPS3; RPS24; RPL41; RPL6; RPLP0; RPL21; MRPL52; RPS29; RPL36AL; SRP14; EIF3J; RPL4; RPLP1; RPS17; RPS15A; RPL13; RPL26; RPL23A; RPL23; RPL19; RPL27; RPL38; RPL17; RPN2; RPS15; EEF2; RPS28; RPL18A; RPS16; RPS19; RPL18; RPL13A; RPS5; EIF3L; RPL3
R-HSA-114608	Platelet degranulation	2.41	1.02e-03	1.92e-02	14/43	TAGLN2; CALM2; MANF; TMSB4X; HSPA5; SERPING1; APLP2; VCL; CD63; CALM1; ALDOA; PFN1; LGALS3BP; CALM3
R-HSA-76005	Response to elevated platelet cytosolic Ca2+	2.41	1.02e-03	1.92e-02	14/43	TAGLN2; CALM2; MANF; TMSB4X; HSPA5; SERPING1; APLP2; VCL; CD63; CALM1; ALDOA; PFN1; LGALS3BP; CALM3
R-HSA-1428517	The citric acid (TCA) cycle and respiratory electron transport	2.38	3.40e-09	8.13e-08	46/143	NDUFS5; COX5B; ATP5G3; NDUFAF3; NDUFB4; ATP5I; UQCRQ; NDUFA2; NDUFA4; CYCS; ATP5J2; NDUFA5; NDUFB2; NDUFB11; COX7B; NDUFA1; UQCRB; COX6C; NDUFB9; LDHA; COX8A; NDUFS8; NDUFC2; NDUFB8; ATP5B; COX5A; NDUFB10; NDUFAB1; ATP5G1; ATP5H; ATP5A1; BSG; UQCR11; NDUFA11; NDUFA7; NDUFB7; NDUFA13; COX6B1; ETFB; NDUFA3; NDUFA6; ATP5J; MT-ND1; MT-ND3; MT-ND4; MT-ND6
R-HSA-422475	Axon guidance	2.28	0.00e+00	0.00e+00	101/328	RPL22; EPHB2; RPL11; RPS8; RPL5; RPS27; SHC1; LHX9; RPS27A; RPL31; SCN3A; SCN9A; NRP2; RPL37A; RPL32; RPL15; RPSA; RPL14; ROBO1; RPL24; ALCAM; GAP43; RPL22L1; AP2M1; RPL35A; RPL9; RPL34; RPS3A; RPL37; RPS23; RGMB; DPYSL3; RPS14; PDLIM7; TUBB2B; CAP2; RPS10; RPS12; EZR; SHFM1; RPS4X; RPL36A; DCX; RPL39; RPL10; DPYSL2; ANK1; RPS20; RPL7; TCEB1; RPL30; RPL8; RPS6; SPTAN1; RPL7A; RPL27A; RPS13; RPS3; HSPA8; RPS24; CACNB3; RPL41; MYL6; SRGAP1; RPL6; RPLP0; RPL21; RPS29; RPL36AL; HSP90AA1; RPL4; RPLP1; RPS17; TCEB2; RPS15A; RPL13; PFN1; EFNB3; RPL26; RPL23A; PSMB3; RPL23; RPL19; RPL27; RPL38; EIF4A3; MYL12A; MYL12B; RPL17; DCC; PSMA7; RPS15; TUBB4A; RPS28; RPL18A; RPS16; RPS19; RPL18; RPL13A; RPS5; RPL3

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PTEN : 46 significant Reactome pathways

GeneSet	description	enrichRatio	pValue	FDR	GeneRatio	geneSymbols
R-HSA-156902	Peptide chain elongation	5.94	0.00e+00	0.00e+00	80/84	RPL22; RPL11; RPS8; RPL5; RPS27; RPS7; RPS27A; RPL31; RPL37A; RPL32; RPL15; RPSA; RPL14; RPL29; RPL24; RPL35A; RPL9; RPL34; RPS3A; RPL37; RPS23; RPS14; RPS18; RPS10; RPL10A; EEF1A1; RPS12; RPS4X; RPL36A; RPL39; RPL10; RPS20; RPL7; RPL30; RPL8; RPS6; RPL12; RPL7A; RPLP2; RPL27A; RPS13; RPS3; RPS25; RPS24; RPS26; RPL41; RPL6; RPLP0; RPL21; RPS29; RPL36AL; RPL4; RPLP1; RPS17; RPS2; RPS15A; RPL13; RPL26; RPL23A; RPL23; RPL19; RPL27; RPL38; RPL17; RPS21; RPS15; EEF2; RPL36; RPS28; RPL18A; UBA52; RPS16; RPS19; RPL18; RPL13A; RPS11; RPS9; RPL28; RPS5; RPL3
R-HSA-192823	Viral mRNA Translation	5.87	0.00e+00	0.00e+00	78/83	RPL22; RPL11; RPS8; RPL5; RPS27; RPS7; RPS27A; RPL31; RPL37A; RPL32; RPL15; RPSA; RPL14; RPL29; RPL24; RPL35A; RPL9; RPL34; RPS3A; RPL37; RPS23; RPS14; RPS18; RPS10; RPL10A; RPS12; RPS4X; RPL36A; RPL39; RPL10; RPS20; RPL7; RPL30; RPL8; RPS6; RPL12; RPL7A; RPLP2; RPL27A; RPS13; RPS3; RPS25; RPS24; RPS26; RPL41; RPL6; RPLP0; RPL21; RPS29; RPL36AL; RPL4; RPLP1; RPS17; RPS2; RPS15A; RPL13; RPL26; RPL23A; RPL23; RPL19; RPL27; RPL38; RPL17; RPS21; RPS15; RPL36; RPS28; RPL18A; UBA52; RPS16; RPS19; RPL18; RPL13A; RPS11; RPS9; RPL28; RPS5; RPL3
R-HSA-156842	Eukaryotic Translation Elongation	5.81	0.00e+00	0.00e+00	80/86	RPL22; RPL11; RPS8; RPL5; RPS27; RPS7; RPS27A; RPL31; RPL37A; RPL32; RPL15; RPSA; RPL14; RPL29; RPL24; RPL35A; RPL9; RPL34; RPS3A; RPL37; RPS23; RPS14; RPS18; RPS10; RPL10A; EEF1A1; RPS12; RPS4X; RPL36A; RPL39; RPL10; RPS20; RPL7; RPL30; RPL8; RPS6; RPL12; RPL7A; RPLP2; RPL27A; RPS13; RPS3; RPS25; RPS24; RPS26; RPL41; RPL6; RPLP0; RPL21; RPS29; RPL36AL; RPL4; RPLP1; RPS17; RPS2; RPS15A; RPL13; RPL26; RPL23A; RPL23; RPL19; RPL27; RPL38; RPL17; RPS21; RPS15; EEF2; RPL36; RPS28; RPL18A; UBA52; RPS16; RPS19; RPL18; RPL13A; RPS11; RPS9; RPL28; RPS5; RPL3
R-HSA-72764	Eukaryotic Translation Termination	5.73	0.00e+00	0.00e+00	79/86	RPL22; RPL11; RPS8; RPL5; RPS27; RPS7; RPS27A; RPL31; RPL37A; RPL32; RPL15; RPSA; RPL14; RPL29; RPL24; RPL35A; RPL9; RPL34; RPS3A; RPL37; RPS23; RPS14; RPS18; RPS10; RPL10A; RPS12; RPS4X; RPL36A; RPL39; RPL10; RPS20; RPL7; RPL30; RPL8; RPS6; RPL12; RPL7A; RPLP2; RPL27A; RPS13; TRMT112; RPS3; RPS25; RPS24; RPS26; RPL41; RPL6; RPLP0; RPL21; RPS29; RPL36AL; RPL4; RPLP1; RPS17; RPS2; RPS15A; RPL13; RPL26; RPL23A; RPL23; RPL19; RPL27; RPL38; RPL17; RPS21; RPS15; RPL36; RPS28; RPL18A; UBA52; RPS16; RPS19; RPL18; RPL13A; RPS11; RPS9; RPL28; RPS5; RPL3
R-HSA-2408557	Selenocysteine synthesis	5.73	0.00e+00	0.00e+00	78/85	RPL22; RPL11; RPS8; RPL5; RPS27; RPS7; RPS27A; RPL31; RPL37A; RPL32; RPL15; RPSA; RPL14; RPL29; RPL24; RPL35A; RPL9; RPL34; RPS3A; RPL37; RPS23; RPS14; RPS18; RPS10; RPL10A; RPS12; RPS4X; RPL36A; RPL39; RPL10; RPS20; RPL7; RPL30; RPL8; RPS6; RPL12; RPL7A; RPLP2; RPL27A; RPS13; RPS3; RPS25; RPS24; RPS26; RPL41; RPL6; RPLP0; RPL21; RPS29; RPL36AL; RPL4; RPLP1; RPS17; RPS2; RPS15A; RPL13; RPL26; RPL23A; RPL23; RPL19; RPL27; RPL38; RPL17; RPS21; RPS15; RPL36; RPS28; RPL18A; UBA52; RPS16; RPS19; RPL18; RPL13A; RPS11; RPS9; RPL28; RPS5; RPL3
R-HSA-975956	Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)	5.60	0.00e+00	0.00e+00	79/88	RPL22; RPL11; RPS8; RPL5; RPS27; RPS7; RPS27A; RPL31; RPL37A; RPL32; RPL15; RPSA; RPL14; RPL29; RPL24; RPL35A; RPL9; RPL34; RPS3A; RPL37; RPS23; RPS14; RPS18; RPS10; RPL10A; RPS12; RPS4X; RPL36A; RPL39; RPL10; RPS20; RPL7; RPL30; PABPC1; RPL8; RPS6; RPL12; RPL7A; RPLP2; RPL27A; RPS13; RPS3; RPS25; RPS24; RPS26; RPL41; RPL6; RPLP0; RPL21; RPS29; RPL36AL; RPL4; RPLP1; RPS17; RPS2; RPS15A; RPL13; RPL26; RPL23A; RPL23; RPL19; RPL27; RPL38; RPL17; RPS21; RPS15; RPL36; RPS28; RPL18A; UBA52; RPS16; RPS19; RPL18; RPL13A; RPS11; RPS9; RPL28; RPS5; RPL3
R-HSA-72689	Formation of a pool of free 40S subunits	5.58	0.00e+00	0.00e+00	85/95	RPL22; RPL11; RPS8; RPL5; RPS27; RPS7; RPS27A; RPL31; RPL37A; RPL32; RPL15; RPSA; RPL14; RPL29; RPL24; RPL35A; RPL9; RPL34; RPS3A; RPL37; RPS23; RPS14; RPS18; RPS10; RPL10A; RPS12; RPS4X; RPL36A; RPL39; RPL10; RPS20; RPL7; RPL30; EIF3E; EIF3H; RPL8; RPS6; RPL12; RPL7A; RPLP2; EIF3F; RPL27A; RPS13; EIF3M; RPS3; RPS25; RPS24; RPS26; RPL41; RPL6; RPLP0; RPL21; RPS29; RPL36AL; EIF3J; RPL4; RPLP1; RPS17; RPS2; RPS15A; RPL13; RPL26; RPL23A; RPL23; RPL19; RPL27; RPL38; RPL17; RPS21; RPS15; RPL36; RPS28; RPL18A; UBA52; RPS16; RPS19; RPL18; RPL13A; RPS11; RPS9; RPL28; RPS5; EIF3D; EIF3L; RPL3
R-HSA-156827	L13a-mediated translational silencing of Ceruloplasmin expression	5.23	0.00e+00	0.00e+00	88/105	RPL22; RPL11; RPS8; RPL5; RPS27; RPS7; RPS27A; RPL31; RPL37A; RPL32; RPL15; RPSA; RPL14; RPL29; RPL24; EIF4A2; RPL35A; RPL9; RPL34; RPS3A; RPL37; RPS23; RPS14; RPS18; RPS10; RPL10A; RPS12; RPS4X; RPL36A; RPL39; RPL10; RPS20; RPL7; RPL30; PABPC1; EIF3E; EIF3H; RPL8; RPS6; RPL12; RPL7A; RPLP2; EIF3F; RPL27A; RPS13; EIF3M; RPS3; RPS25; RPS24; RPS26; RPL41; RPL6; RPLP0; RPL21; RPS29; RPL36AL; EIF3J; RPL4; RPLP1; RPS17; RPS2; RPS15A; RPL13; RPL26; RPL23A; RPL23; RPL19; RPL27; RPL38; RPL17; EIF2S2; RPS21; RPS15; RPL36; RPS28; RPL18A; UBA52; RPS16; RPS19; RPL18; RPL13A; RPS11; RPS9; RPL28; RPS5; EIF3D; EIF3L; RPL3
R-HSA-72706	GTP hydrolysis and joining of the 60S ribosomal subunit	5.12	0.00e+00	0.00e+00	87/106	RPL22; RPL11; RPS8; RPL5; RPS27; RPS7; RPS27A; RPL31; RPL37A; RPL32; RPL15; RPSA; RPL14; RPL29; RPL24; EIF4A2; RPL35A; RPL9; RPL34; RPS3A; RPL37; RPS23; RPS14; RPS18; RPS10; RPL10A; RPS12; RPS4X; RPL36A; RPL39; RPL10; RPS20; RPL7; RPL30; EIF3E; EIF3H; RPL8; RPS6; RPL12; RPL7A; RPLP2; EIF3F; RPL27A; RPS13; EIF3M; RPS3; RPS25; RPS24; RPS26; RPL41; RPL6; RPLP0; RPL21; RPS29; RPL36AL; EIF3J; RPL4; RPLP1; RPS17; RPS2; RPS15A; RPL13; RPL26; RPL23A; RPL23; RPL19; RPL27; RPL38; RPL17; EIF2S2; RPS21; RPS15; RPL36; RPS28; RPL18A; UBA52; RPS16; RPS19; RPL18; RPL13A; RPS11; RPS9; RPL28; RPS5; EIF3D; EIF3L; RPL3
R-HSA-72695	Formation of the ternary complex, and subsequently, the 43S complex	5.07	0.00e+00	0.00e+00	39/48	RPS8; RPS27; RPS7; RPS27A; RPSA; RPS3A; RPS23; RPS14; RPS18; RPS10; RPS12; RPS4X; RPS20; EIF3E; EIF3H; RPS6; EIF3F; RPS13; EIF3M; RPS3; RPS25; RPS24; RPS26; RPS29; EIF3J; RPS17; RPS2; RPS15A; EIF2S2; RPS21; RPS15; RPS28; RPS16; RPS19; RPS11; RPS9; RPS5; EIF3D; EIF3L
R-HSA-2408522	Selenoamino acid metabolism	4.98	0.00e+00	0.00e+00	79/99	RPL22; RPL11; RPS8; RPL5; RPS27; RPS7; RPS27A; RPL31; RPL37A; RPL32; RPL15; RPSA; RPL14; QARS; RPL29; RPL24; RPL35A; RPL9; RPL34; RPS3A; RPL37; RPS23; RPS14; RPS18; RPS10; RPL10A; RPS12; RPS4X; RPL36A; RPL39; RPL10; RPS20; RPL7; RPL30; RPL8; RPS6; RPL12; RPL7A; RPLP2; RPL27A; RPS13; RPS3; RPS25; RPS24; RPS26; RPL41; RPL6; RPLP0; RPL21; RPS29; RPL36AL; RPL4; RPLP1; RPS17; RPS2; RPS15A; RPL13; RPL26; RPL23A; RPL23; RPL19; RPL27; RPL38; RPL17; RPS21; RPS15; RPL36; RPS28; RPL18A; UBA52; RPS16; RPS19; RPL18; RPL13A; RPS11; RPS9; RPL28; RPS5; RPL3
R-HSA-1799339	SRP-dependent cotranslational protein targeting to membrane	4.92	0.00e+00	0.00e+00	82/104	RPL22; RPL11; RPS8; RPL5; RPS27; RPS7; RPS27A; RPL31; RPL37A; RPL32; RPL15; RPSA; RPL14; RPL29; RPL24; RPL35A; RPL9; RPL34; RPS3A; RPL37; RPS23; RPS14; RPS18; RPS10; RPL10A; RPS12; SEC61G; RPS4X; RPL36A; RPL39; RPL10; RPS20; RPL7; RPL30; RPL8; RPS6; SEC61B; RPL12; RPL7A; RPLP2; RPL27A; RPS13; RPS3; RPS25; RPS24; RPS26; RPL41; RPL6; RPLP0; RPL21; RPS29; RPL36AL; SRP14; RPL4; RPLP1; RPS17; SEC11A; RPS2; RPS15A; RPL13; RPL26; RPL23A; RPL23; RPL19; RPL27; RPL38; RPL17; RPS21; RPS15; RPL36; RPS28; RPL18A; UBA52; RPS16; RPS19; RPL18; RPL13A; RPS11; RPS9; RPL28; RPS5; RPL3
R-HSA-72613	Eukaryotic Translation Initiation	4.86	0.00e+00	0.00e+00	88/113	RPL22; RPL11; RPS8; RPL5; RPS27; RPS7; RPS27A; RPL31; RPL37A; RPL32; RPL15; RPSA; RPL14; RPL29; RPL24; EIF4A2; RPL35A; RPL9; RPL34; RPS3A; RPL37; RPS23; RPS14; RPS18; RPS10; RPL10A; RPS12; RPS4X; RPL36A; RPL39; RPL10; RPS20; RPL7; RPL30; PABPC1; EIF3E; EIF3H; RPL8; RPS6; RPL12; RPL7A; RPLP2; EIF3F; RPL27A; RPS13; EIF3M; RPS3; RPS25; RPS24; RPS26; RPL41; RPL6; RPLP0; RPL21; RPS29; RPL36AL; EIF3J; RPL4; RPLP1; RPS17; RPS2; RPS15A; RPL13; RPL26; RPL23A; RPL23; RPL19; RPL27; RPL38; RPL17; EIF2S2; RPS21; RPS15; RPL36; RPS28; RPL18A; UBA52; RPS16; RPS19; RPL18; RPL13A; RPS11; RPS9; RPL28; RPS5; EIF3D; EIF3L; RPL3
R-HSA-72737	Cap-dependent Translation Initiation	4.86	0.00e+00	0.00e+00	88/113	RPL22; RPL11; RPS8; RPL5; RPS27; RPS7; RPS27A; RPL31; RPL37A; RPL32; RPL15; RPSA; RPL14; RPL29; RPL24; EIF4A2; RPL35A; RPL9; RPL34; RPS3A; RPL37; RPS23; RPS14; RPS18; RPS10; RPL10A; RPS12; RPS4X; RPL36A; RPL39; RPL10; RPS20; RPL7; RPL30; PABPC1; EIF3E; EIF3H; RPL8; RPS6; RPL12; RPL7A; RPLP2; EIF3F; RPL27A; RPS13; EIF3M; RPS3; RPS25; RPS24; RPS26; RPL41; RPL6; RPLP0; RPL21; RPS29; RPL36AL; EIF3J; RPL4; RPLP1; RPS17; RPS2; RPS15A; RPL13; RPL26; RPL23A; RPL23; RPL19; RPL27; RPL38; RPL17; EIF2S2; RPS21; RPS15; RPL36; RPS28; RPL18A; UBA52; RPS16; RPS19; RPL18; RPL13A; RPS11; RPS9; RPL28; RPS5; EIF3D; EIF3L; RPL3
R-HSA-927802	Nonsense-Mediated Decay (NMD)	4.76	0.00e+00	0.00e+00	80/105	RPL22; RPL11; RPS8; RPL5; RPS27; RPS7; RPS27A; RPL31; RPL37A; RPL32; RPL15; RPSA; RPL14; RPL29; RPL24; RPL35A; RPL9; RPL34; RPS3A; RPL37; RPS23; RPS14; RPS18; RPS10; RPL10A; RPS12; RPS4X; RPL36A; RPL39; RPL10; RPS20; RPL7; RPL30; PABPC1; RPL8; RPS6; RPL12; RPL7A; RPLP2; RPL27A; RPS13; RPS3; RPS25; RPS24; RPS26; RPL41; RPL6; RPLP0; RPL21; RPS29; RPL36AL; RPL4; RPLP1; RPS17; RPS2; RPS15A; RPL13; RPL26; RPL23A; RPL23; RPL19; RPL27; RPL38; EIF4A3; RPL17; RPS21; RPS15; RPL36; RPS28; RPL18A; UBA52; RPS16; RPS19; RPL18; RPL13A; RPS11; RPS9; RPL28; RPS5; RPL3
R-HSA-975957	Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)	4.76	0.00e+00	0.00e+00	80/105	RPL22; RPL11; RPS8; RPL5; RPS27; RPS7; RPS27A; RPL31; RPL37A; RPL32; RPL15; RPSA; RPL14; RPL29; RPL24; RPL35A; RPL9; RPL34; RPS3A; RPL37; RPS23; RPS14; RPS18; RPS10; RPL10A; RPS12; RPS4X; RPL36A; RPL39; RPL10; RPS20; RPL7; RPL30; PABPC1; RPL8; RPS6; RPL12; RPL7A; RPLP2; RPL27A; RPS13; RPS3; RPS25; RPS24; RPS26; RPL41; RPL6; RPLP0; RPL21; RPS29; RPL36AL; RPL4; RPLP1; RPS17; RPS2; RPS15A; RPL13; RPL26; RPL23A; RPL23; RPL19; RPL27; RPL38; EIF4A3; RPL17; RPS21; RPS15; RPL36; RPS28; RPL18A; UBA52; RPS16; RPS19; RPL18; RPL13A; RPS11; RPS9; RPL28; RPS5; RPL3
R-HSA-72649	Translation initiation complex formation	4.65	0.00e+00	0.00e+00	41/55	RPS8; RPS27; RPS7; RPS27A; RPSA; EIF4A2; RPS3A; RPS23; RPS14; RPS18; RPS10; RPS12; RPS4X; RPS20; PABPC1; EIF3E; EIF3H; RPS6; EIF3F; RPS13; EIF3M; RPS3; RPS25; RPS24; RPS26; RPS29; EIF3J; RPS17; RPS2; RPS15A; EIF2S2; RPS21; RPS15; RPS28; RPS16; RPS19; RPS11; RPS9; RPS5; EIF3D; EIF3L
R-HSA-72662	Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S	4.57	0.00e+00	0.00e+00	41/56	RPS8; RPS27; RPS7; RPS27A; RPSA; EIF4A2; RPS3A; RPS23; RPS14; RPS18; RPS10; RPS12; RPS4X; RPS20; PABPC1; EIF3E; EIF3H; RPS6; EIF3F; RPS13; EIF3M; RPS3; RPS25; RPS24; RPS26; RPS29; EIF3J; RPS17; RPS2; RPS15A; EIF2S2; RPS21; RPS15; RPS28; RPS16; RPS19; RPS11; RPS9; RPS5; EIF3D; EIF3L
R-HSA-72702	Ribosomal scanning and start codon recognition	4.54	0.00e+00	0.00e+00	40/55	RPS8; RPS27; RPS7; RPS27A; RPSA; EIF4A2; RPS3A; RPS23; RPS14; RPS18; RPS10; RPS12; RPS4X; RPS20; EIF3E; EIF3H; RPS6; EIF3F; RPS13; EIF3M; RPS3; RPS25; RPS24; RPS26; RPS29; EIF3J; RPS17; RPS2; RPS15A; EIF2S2; RPS21; RPS15; RPS28; RPS16; RPS19; RPS11; RPS9; RPS5; EIF3D; EIF3L
R-HSA-168273	Influenza Viral RNA Transcription and Replication	4.53	0.00e+00	0.00e+00	82/113	RPL22; RPL11; RPS8; RPL5; RPS27; RPS7; RPS27A; RPL31; RPL37A; RPL32; RPL15; RPSA; RPL14; RPL29; RPL24; RPL35A; RPL9; RPL34; RPS3A; RPL37; RPS23; RPS14; RPS18; RPS10; RPL10A; RPS12; POLR2J; RPS4X; RPL36A; RPL39; RPL10; RPS20; RPL7; RPL30; POLR2K; RPL8; RPS6; RPL12; RPL7A; RPLP2; POLR2L; RPL27A; RPS13; RPS3; RPS25; RPS24; RPS26; RPL41; RPL6; RPLP0; RPL21; RPS29; RPL36AL; RPL4; RPLP1; RPS17; RPS2; RPS15A; RPL13; RPL26; RPL23A; RPL23; RPL19; RPL27; RPL38; RPL17; RPS21; RPS15; RPL36; RPS28; RPL18A; UBA52; RPS16; RPS19; RPL18; RPL13A; RPS11; RPS9; RPL28; RPS5; POLR2F; RPL3
R-HSA-168255	Influenza Life Cycle	4.33	0.00e+00	0.00e+00	84/121	RPL22; RPL11; RPS8; RPL5; RPS27; RPS7; RPS27A; RPL31; RPL37A; RPL32; RPL15; RPSA; RPL14; RPL29; RPL24; RPL35A; RPL9; RPL34; RPS3A; RPL37; RPS23; RPS14; CANX; RPS18; RPS10; RPL10A; RPS12; POLR2J; RPS4X; RPL36A; RPL39; RPL10; RPS20; RPL7; RPL30; POLR2K; RPL8; RPS6; RPL12; RPL7A; RPLP2; POLR2L; RPL27A; RPS13; RPS3; RPS25; RPS24; RPS26; RPL41; RPL6; RPLP0; RPL21; RPS29; RPL36AL; RPL4; RPLP1; RPS17; RPS2; RPS15A; RPL13; RPL26; RPL23A; RPL23; RPL19; RPL27; RPL38; RPL17; RPS21; RPS15; RPL36; RPS28; CALR; RPL18A; UBA52; RPS16; RPS19; RPL18; RPL13A; RPS11; RPS9; RPL28; RPS5; POLR2F; RPL3
R-HSA-168254	Influenza Infection	4.19	0.00e+00	0.00e+00	86/128	RPL22; RPL11; RPS8; RPL5; RPS27; RPS7; RPS27A; RPL31; RPL37A; RPL32; RPL15; RPSA; RPL14; RPL29; RPL24; RPL35A; RPL9; RPL34; RPS3A; RPL37; RPS23; RPS14; CANX; RPS18; RPS10; RPL10A; RPS12; POLR2J; SLC25A6; RPS4X; RPL36A; RPL39; RPL10; RPS20; RPL7; RPL30; POLR2K; RPL8; RPS6; RPL12; RPL7A; RPLP2; POLR2L; RPL27A; RPS13; RPS3; RPS25; RPS24; RPS26; RPL41; RPL6; RPLP0; RPL21; RPS29; RPL36AL; RPL4; RPLP1; RPS17; RPS2; RPS15A; RPL13; RPL26; RPL23A; RPL23; RPL19; RPL27; KPNA2; RPL38; RPL17; RPS21; RPS15; RPL36; RPS28; CALR; RPL18A; UBA52; RPS16; RPS19; RPL18; RPL13A; RPS11; RPS9; RPL28; RPS5; POLR2F; RPL3
R-HSA-163210	Formation of ATP by chemiosmotic coupling	3.81	1.76e-05	3.99e-04	11/18	ATP5G3; ATP5I; ATP5J2; ATP5L; ATP5G2; ATP5G1; ATP5H; ATP5A1; ATP5E; ATP5J; ATP5O
R-HSA-8876725	Protein methylation	3.64	9.90e-04	1.89e-02	7/12	CALM2; EEF1A1; CALM1; RPS2; EEF2; ETFB
R-HSA-9010553	Regulation of expression of SLITs and ROBOs	3.60	0.00e+00	0.00e+00	86/149	RPL22; RPL11; RPS8; RPL5; RPS27; LHX9; RPS7; RPS27A; RPL31; RPL37A; RPL32; RPL15; RPSA; RPL14; RPL29; RPL24; RPL35A; RPL9; RPL34; RPS3A; RPL37; RPS23; RPS14; RPS18; RPS10; RPL10A; RPS12; SHFM1; RPS4X; RPL36A; RPL39; RPL10; RPS20; RPL7; TCEB1; RPL30; PABPC1; RPL8; RPS6; RPL12; RPL7A; RPLP2; RPL27A; RPS13; RPS3; RPS25; RPS24; RPS26; RPL41; RPL6; RPLP0; RPL21; RPS29; RPL36AL; RPL4; RPLP1; RPS17; RPS2; TCEB2; RPS15A; RPL13; RPL26; RPL23A; RPL23; RPL19; RPL27; RPL38; EIF4A3; RPL17; PSMA7; RPS21; RPS15; RPL36; RPS28; RPL18A; UBA52; RPS16; RPS19; RPL18; RPL13A; RPS11; RPS9; RPL28; RPS5; RPL3; RBX1
R-HSA-6791226	Major pathway of rRNA processing in the nucleolus and cytosol	3.28	0.00e+00	0.00e+00	81/154	RPL22; RPL11; RPS8; RPL5; RPS27; RPS7; RPS27A; RPL31; RPL37A; NCL; RPL32; RPL15; RPSA; RPL14; RPL29; RPL24; RPL35A; RPL9; RPL34; RPS3A; RPL37; RPS23; RPS14; RPS18; RPS10; RPL10A; RPS12; RPS4X; RPL36A; RPL39; RPL10; RPS20; RPL7; RPL30; RPL8; RPS6; RPL12; RPL7A; RPLP2; RPL27A; RPS13; RPS3; RPS25; DDX21; RPS24; RPS26; RPL41; RPL6; RPLP0; RPL21; RPS29; RPL36AL; RPL4; RPLP1; RPS17; RPS2; RPS15A; RPL13; RPL26; RPL23A; RPL23; RPL19; RPL27; RPL38; RPL17; RPS21; RPS15; RPL36; RPS28; RPL18A; UBA52; RPS16; RPS19; RPL18; RPL13A; RPS11; RPS9; RPL28; RPS5; RPL3; SNU13
R-HSA-8868773	rRNA processing in the nucleus and cytosol	3.28	0.00e+00	0.00e+00	84/160	RPL22; RPL11; RPS8; RPL5; RPS27; RPS7; RPS27A; RPL31; RPL37A; NCL; RPL32; RPL15; RPSA; RPL14; RPL29; RPL24; RPL35A; RPL9; RPL34; RPS3A; RPL37; RPS23; RPS14; NHP2; RPS18; RPS10; RPL10A; RPS12; RPS4X; RPL36A; RPL39; RPL10; RPS20; RPL7; RPL30; RPL8; RPS6; RPL12; RPL7A; RPLP2; RPL27A; RPS13; TRMT112; RPS3; RPS25; DDX21; RPS24; RPS26; RPL41; RPL6; RPLP0; RPL21; RPS29; RPL36AL; NOP10; RPL4; RPLP1; RPS17; RPS2; RPS15A; RPL13; RPL26; RPL23A; RPL23; RPL19; RPL27; RPL38; RPL17; RPS21; RPS15; RPL36; RPS28; RPL18A; UBA52; RPS16; RPS19; RPL18; RPL13A; RPS11; RPS9; RPL28; RPS5; RPL3; SNU13
R-HSA-5578775	Ion homeostasis	3.26	6.28e-05	1.32e-03	12/23	ATP1B1; ATP2B4; RYR2; FKBP1B; CALM2; ATP1B3; SRI; FXYD6; ATP2B1; CALM1; FXYD7
R-HSA-6799198	Complex I biogenesis	3.24	1.71e-09	3.98e-08	27/52	NDUFS5; NDUFB3; NDUFAF3; NDUFB4; NDUFC1; NDUFS6; NDUFS4; NDUFA2; NDUFA5; NDUFA1; NDUFB6; NDUFB8; NDUFA12; NDUFB1; NDUFAB1; NDUFS7; NDUFA11; NDUFA7; NDUFB7; NDUFA13; NDUFA3; NDUFA6; MT-ND1; MT-ND2; MT-ND3; MT-ND4; MT-ND6
R-HSA-72312	rRNA processing	3.23	0.00e+00	0.00e+00	85/164	RPL22; RPL11; RPS8; RPL5; RPS27; RPS7; RPS27A; RPL31; RPL37A; NCL; RPL32; RPL15; RPSA; RPL14; RPL29; RPL24; RPL35A; RPL9; RPL34; RPS3A; RPL37; RPS23; RPS14; NHP2; RPS18; RPS10; RPL10A; RPS12; HSD17B10; RPS4X; RPL36A; RPL39; RPL10; RPS20; RPL7; RPL30; RPL8; RPS6; RPL12; RPL7A; RPLP2; RPL27A; RPS13; TRMT112; RPS3; RPS25; DDX21; RPS24; RPS26; RPL41; RPL6; RPLP0; RPL21; RPS29; RPL36AL; NOP10; RPL4; RPLP1; RPS17; RPS2; RPS15A; RPL13; RPL26; RPL23A; RPL23; RPL19; RPL27; RPL38; RPL17; RPS21; RPS15; RPL36; RPS28; RPL18A; UBA52; RPS16; RPS19; RPL18; RPL13A; RPS11; RPS9; RPL28; RPS5; RPL3; SNU13
R-HSA-376176	Signaling by ROBO receptors	3.16	0.00e+00	0.00e+00	90/178	RPL22; RPL11; RPS8; RPL5; RPS27; LHX9; RPS7; RPS27A; RPL31; RPL37A; SRGAP3; RPL32; RPL15; RPSA; RPL14; RPL29; RPL24; RPL35A; RPL9; RPL34; RPS3A; RPL37; RPS23; RPS14; CAP2; RPS18; RPS10; RPL10A; RPS12; SHFM1; RPS4X; RPL36A; RPL39; RPL10; RPS20; RPL7; TCEB1; RPL30; PABPC1; RPL8; RPS6; RPL12; RPL7A; RPLP2; RPL27A; RPS13; RPS3; RPS25; RPS24; RPS26; RPL41; SRGAP1; RPL6; RPLP0; RPL21; RPS29; RPL36AL; RPL4; RPLP1; RPS17; RPS2; TCEB2; RPS15A; RPL13; RPL26; RPL23A; RPL23; RPL19; RPL27; RPL38; EIF4A3; RPL17; DCC; PSMA7; RPS21; RPS15; RPL36; RPS28; RPL18A; UBA52; RPS16; RPS19; RPL18; RPL13A; RPS11; RPS9; RPL28; RPS5; RPL3; RBX1
R-HSA-163200	Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.	3.01	2.22e-16	5.79e-15	55/114	NDUFS5; COX20; COX7A2L; COX5B; ATP5G3; NDUFB3; NDUFAF3; NDUFB4; ATP5I; NDUFC1; NDUFS6; NDUFS4; COX7C; UQCRQ; NDUFA2; NDUFA4; CYCS; ATP5J2; NDUFA5; COX7B; NDUFA1; COX6C; NDUFB6; COX8A; ATP5L; NDUFB8; COX14; ATP5G2; NDUFA12; COX6A1; COX16; NDUFB1; NDUFAB1; ATP5G1; ATP5H; ATP5A1; ATP5E; NDUFS7; UQCR11; NDUFA11; NDUFA7; NDUFB7; NDUFA13; COX6B1; ETFB; NDUFA3; UQCR10; NDUFA6; ATP5J; ATP5O; MT-ND1; MT-ND2; MT-ND3; MT-ND4; MT-ND6
R-HSA-500792	GPCR ligand binding	3.01	9.09e-05	1.86e-03	13/27	GNG5; AGT; SST; GRM4; FZD1; GABBR2; GNG3; GAL; NMB; SSTR2; GNAS; GNG8; PTH2
R-HSA-611105	Respiratory electron transport	2.89	1.81e-12	4.45e-11	44/95	NDUFS5; COX20; COX7A2L; COX5B; NDUFB3; NDUFAF3; NDUFB4; NDUFC1; NDUFS6; NDUFS4; COX7C; UQCRQ; NDUFA2; NDUFA4; CYCS; NDUFA5; COX7B; NDUFA1; COX6C; NDUFB6; COX8A; NDUFB8; COX14; NDUFA12; COX6A1; COX16; NDUFB1; NDUFAB1; NDUFS7; UQCR11; NDUFA11; NDUFA7; NDUFB7; NDUFA13; COX6B1; ETFB; NDUFA3; UQCR10; NDUFA6; MT-ND1; MT-ND2; MT-ND3; MT-ND4; MT-ND6
R-HSA-5576891	Cardiac conduction	2.85	3.14e-05	6.93e-04	16/35	ATP1B1; ATP2B4; RYR2; FKBP1B; CALM2; SCN3A; SCN9A; ATP1B3; SRI; AKAP9; FXYD6; KCNIP2; ATP2B1; CALM1; FXYD7
R-HSA-71291	Metabolism of amino acids and derivatives	2.63	0.00e+00	0.00e+00	88/209	RPL22; RPL11; RPS8; RPL5; PHGDH; RPS27; RPS7; RPS27A; RPL31; RPL37A; RPL32; RPL15; RPSA; RPL14; QARS; RPL29; RPL24; RPL35A; RPL9; RPL34; RPS3A; RPL37; RPS23; RPS14; RPS18; RPS10; RPL10A; RPS12; SHFM1; SAT1; HSD17B10; RPS4X; RPL36A; RPL39; RPL10; RPS20; RPL7; RPL30; RPL8; RPS6; RPL12; RPL7A; RPLP2; RPL27A; RPS13; RPS3; RPS25; RPS24; BCAT1; RPS26; RPL41; RPL6; RPLP0; PXMP2; RPL21; RPS29; RPL36AL; CKB; RPL4; RPLP1; RPS17; RPS2; RPS15A; NDUFAB1; RPL13; RPL26; RPL23A; RPL23; RPL19; RPL27; RPL38; RPL17; PSMA7; RPS21; RPS15; RPL36; RPS28; RPL18A; UBA52; RPS16; RPS19; RPL18; RPL13A; RPS11; RPS9; RPL28; RPS5; RPL3
R-HSA-2672351	Stimuli-sensing channels	2.60	2.38e-03	4.19e-02	10/24	RYR2; FKBP1B; CALM2; RPS27A; SRI; ASIC1; CALM1; TTYH2; UBA52
R-HSA-936837	Ion transport by P-type ATPases	2.60	2.38e-03	4.19e-02	10/24	ATP1B1; ATP2B4; CALM2; ATP1B3; SRI; FXYD6; ATP2B1; CALM1; FXYD7
R-HSA-72766	Translation	2.57	0.00e+00	0.00e+00	106/257	AURKAIP1; MRPL20; RPL22; RPL11; RPS8; RPL5; MRPS21; RPS27; RPS7; MRPL33; RPS27A; RPL31; RPL37A; RPL32; RPL15; RPSA; RPL14; QARS; RPL29; RPL24; EIF4A2; RPL35A; RPL9; RPL34; RPS3A; RPL37; RPS23; RPS14; RPS18; RPS10; RPL10A; MRPL14; EEF1A1; RPS12; SEC61G; RPS4X; RPL36A; RPL39; RPL10; RPS20; RPL7; RPL30; PABPC1; EIF3E; EIF3H; RPL8; RPS6; SEC61B; RPL12; RPL7A; MRPL41; RPLP2; EIF3F; RPL27A; RPS13; EIF3M; TRMT112; RPS3; RPS25; CHCHD1; RPS24; MRPL51; RPS26; RPL41; TSFM; RPL6; RPLP0; RPL21; MRPL52; RPS29; RPL36AL; SRP14; EIF3J; RPL4; RPLP1; RPS17; SEC11A; RPS2; RPS15A; RPL13; RPL26; RPL23A; RPL23; RPL19; RPL27; RPL38; RPL17; EIF2S2; RPS21; RPS15; EEF2; RPL36; RPS28; RPL18A; UBA52; RPS16; RPS19; RPL18; RPL13A; RPS11; RPS9; RPL28; RPS5; EIF3D; EIF3L; RPL3
R-HSA-1428517	The citric acid (TCA) cycle and respiratory electron transport	2.53	5.53e-13	1.40e-11	58/143	NDUFS5; SLC16A1; COX20; COX7A2L; COX5B; ATP5G3; NDUFB3; NDUFAF3; NDUFB4; ATP5I; NDUFC1; NDUFS6; NDUFS4; COX7C; UQCRQ; VDAC1; NDUFA2; NDUFA4; CYCS; ATP5J2; NDUFA5; COX7B; NDUFA1; COX6C; NDUFB6; COX8A; ATP5L; NDUFB8; COX14; ATP5G2; NDUFA12; COX6A1; COX16; NDUFB1; NDUFAB1; ATP5G1; ATP5H; ATP5A1; ATP5E; BSG; NDUFS7; UQCR11; NDUFA11; NDUFA7; NDUFB7; NDUFA13; COX6B1; ETFB; NDUFA3; UQCR10; NDUFA6; ATP5J; ATP5O; MT-ND1; MT-ND2; MT-ND3; MT-ND4; MT-ND6
R-HSA-8949613	Cristae formation	2.50	1.36e-03	2.55e-02	12/30	MINOS1; ATP5G3; ATP5I; ATP5J2; ATP5L; ATP5G2; ATP5G1; ATP5H; ATP5A1; ATP5E; ATP5J; ATP5O
R-HSA-5663205	Infectious disease	2.47	0.00e+00	0.00e+00	109/275	RPL22; RPL11; RPS8; RPL5; RPS27; RPS7; CALM2; RPS27A; RPL31; RPL37A; RPL32; RPL15; RPSA; RPL14; RPL29; RPL24; AP2M1; RPL35A; RPL9; RPL34; RPS3A; RPL37; RPS23; RPS14; NPM1; CANX; RPS18; HMGA1; RPS10; RPL10A; HSP90AB1; RPS12; GTF2H5; PPIA; STX1A; SHFM1; POLR2J; SLC25A6; RPS4X; RPL36A; RPL39; RPL10; RPS20; RPL7; TCEB1; RPL30; POLR2K; RPL8; RPS6; RPL12; RPL7A; RPLP2; POLR2L; RPL27A; RPS13; BANF1; RPS3; RPS25; RPS24; RPS26; RPL41; RPL6; RPLP0; RPL21; RPS29; RPL36AL; CALM1; GTF2A2; RPL4; RPLP1; RPS17; RPS2; TCEB2; RPS15A; RPL13; VAMP2; RPL26; RPL23A; RPL23; RPL19; RPL27; SUPT4H1; KPNA2; RPL38; RPL17; PSMA7; RPS21; RPS15; EEF2; RPL36; RPS28; CALR; RPL18A; UBA52; RPS16; RPS19; AP2S1; RPL18; RPL13A; RPS11; RPS9; RPL28; RPS5; CHMP2A; RANBP1; POLR2F; RPL3; RBX1
R-HSA-397014	Muscle contraction	2.38	5.32e-05	1.15e-03	21/55	ATP1B1; ATP2B4; RYR2; FKBP1B; CALM2; SCN3A; SCN9A; MYL1; ATP1B3; SRI; AKAP9; CALD1; FXYD6; KCNIP2; MYL6B; ATP2B1; CALM1; ACTC1; MYL12A; FXYD7
R-HSA-422475	Axon guidance	2.17	0.00e+00	0.00e+00	114/328	RPL22; RPL11; RPS8; RPL5; RPS27; LHX9; RPS7; RPS27A; RPL31; SCN3A; SCN9A; NRP2; RPL37A; SRGAP3; RPL32; RPL15; RPSA; RPL14; RPL29; RPL24; ALCAM; GAP43; AP2M1; RPL35A; RPL9; RPL34; RPS3A; RPL37; RPS23; SEMA6A; DPYSL3; RPS14; PDLIM7; CAP2; RPS18; RPS10; RPL10A; HSP90AB1; CD24; RPS12; EZR; ACTB; SHFM1; RPS4X; RPL36A; RPL39; RPL10; DPYSL2; ANK1; RPS20; RPL7; TCEB1; RPL30; PABPC1; RPL8; RPS6; RPL12; RPL7A; VAV2; RPLP2; RPL27A; RPS13; CFL1; RPS3; RPS25; RPS24; TUBA1B; RPS26; RPL41; SRGAP1; RPL6; RPLP0; RPL21; RPS29; RPL36AL; RPL4; RPLP1; RPS17; RPS2; TCEB2; RPS15A; RPL13; EFNB3; RPL26; RPL23A; RPL23; RPL19; RPL27; RPL38; EIF4A3; ACTG1; MYL12A; RPL17; DCC; PSMA7; RPS21; RPS15; RPL36; TUBB4A; RPS28; RPL18A; UBA52; PSENEN; RPS16; RPS19; AP2S1; RPL18; RPL13A; RPS11; RPS9; RPL28; RPS5; RPL3; RBX1
R-HSA-983712	Ion channel transport	2.12	5.19e-04	1.02e-02	20/59	ATP1B1; ATP2B4; RYR2; FKBP1B; CALM2; RPS27A; ATP1B3; ATP6V1G2; SRI; ATP6V1F; ATP6V0E2; ATP6V1G1; FXYD6; ASIC1; ATP2B1; CALM1; TTYH2; UBA52; FXYD7
R-HSA-5628897	TP53 Regulates Metabolic Genes	2.08	3.61e-04	7.23e-03	22/66	PRDX1; LAMTOR5; LAMTOR2; COX20; COX7A2L; COX5B; COX7C; NDUFA4; CYCS; LAMTOR4; COX7B; G6PD; COX6C; YWHAZ; TXN; COX8A; PRDX5; COX14; COX6A1; COX16; YWHAE; COX6B1

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SETD5 : 41 significant Reactome pathways

GeneSet	description	enrichRatio	pValue	FDR	GeneRatio	geneSymbols
R-HSA-156902	Peptide chain elongation	11.70	0.00e+00	0.000000	80/84	RPL22; RPL11; RPS8; RPL5; RPS27; RPS7; RPS27A; RPL31; RPL37A; RPL32; RPL15; RPSA; RPL14; RPL29; RPL24; RPL22L1; RPL35A; RPL9; RPL34; RPS3A; RPL37; RPS23; RPS14; RPS18; RPS10; RPL10A; EEF1A1; RPS12; RPS4X; RPL36A; RPL39; RPL10; RPS20; RPL7; RPL30; RPL8; RPS6; RPL35; RPL12; RPL7A; RPLP2; RPL27A; RPS13; RPS3; RPS25; RPS24; RPL41; RPL6; RPLP0; RPL21; RPS29; RPL4; RPLP1; RPS17; RPS2; RPS15A; RPL13; RPL26; RPL23A; RPL23; RPL19; RPL27; RPL38; RPL17; RPS21; RPS15; EEF2; RPL36; RPS28; RPL18A; UBA52; RPS16; RPS19; RPL18; RPL13A; RPS11; RPS9; RPL28; RPS5; RPL3
R-HSA-156842	Eukaryotic Translation Elongation	11.50	0.00e+00	0.000000	81/86	RPL22; RPL11; RPS8; RPL5; RPS27; RPS7; RPS27A; RPL31; EEF1B2; RPL37A; RPL32; RPL15; RPSA; RPL14; RPL29; RPL24; RPL22L1; RPL35A; RPL9; RPL34; RPS3A; RPL37; RPS23; RPS14; RPS18; RPS10; RPL10A; EEF1A1; RPS12; RPS4X; RPL36A; RPL39; RPL10; RPS20; RPL7; RPL30; RPL8; RPS6; RPL35; RPL12; RPL7A; RPLP2; RPL27A; RPS13; RPS3; RPS25; RPS24; RPL41; RPL6; RPLP0; RPL21; RPS29; RPL4; RPLP1; RPS17; RPS2; RPS15A; RPL13; RPL26; RPL23A; RPL23; RPL19; RPL27; RPL38; RPL17; RPS21; RPS15; EEF2; RPL36; RPS28; RPL18A; UBA52; RPS16; RPS19; RPL18; RPL13A; RPS11; RPS9; RPL28; RPS5; RPL3
R-HSA-192823	Viral mRNA Translation	11.50	0.00e+00	0.000000	78/83	RPL22; RPL11; RPS8; RPL5; RPS27; RPS7; RPS27A; RPL31; RPL37A; RPL32; RPL15; RPSA; RPL14; RPL29; RPL24; RPL22L1; RPL35A; RPL9; RPL34; RPS3A; RPL37; RPS23; RPS14; RPS18; RPS10; RPL10A; RPS12; RPS4X; RPL36A; RPL39; RPL10; RPS20; RPL7; RPL30; RPL8; RPS6; RPL35; RPL12; RPL7A; RPLP2; RPL27A; RPS13; RPS3; RPS25; RPS24; RPL41; RPL6; RPLP0; RPL21; RPS29; RPL4; RPLP1; RPS17; RPS2; RPS15A; RPL13; RPL26; RPL23A; RPL23; RPL19; RPL27; RPL38; RPL17; RPS21; RPS15; RPL36; RPS28; RPL18A; UBA52; RPS16; RPS19; RPL18; RPL13A; RPS11; RPS9; RPL28; RPS5; RPL3
R-HSA-2408557	Selenocysteine synthesis	11.20	0.00e+00	0.000000	78/85	RPL22; RPL11; RPS8; RPL5; RPS27; RPS7; RPS27A; RPL31; RPL37A; RPL32; RPL15; RPSA; RPL14; RPL29; RPL24; RPL22L1; RPL35A; RPL9; RPL34; RPS3A; RPL37; RPS23; RPS14; RPS18; RPS10; RPL10A; RPS12; RPS4X; RPL36A; RPL39; RPL10; RPS20; RPL7; RPL30; RPL8; RPS6; RPL35; RPL12; RPL7A; RPLP2; RPL27A; RPS13; RPS3; RPS25; RPS24; RPL41; RPL6; RPLP0; RPL21; RPS29; RPL4; RPLP1; RPS17; RPS2; RPS15A; RPL13; RPL26; RPL23A; RPL23; RPL19; RPL27; RPL38; RPL17; RPS21; RPS15; RPL36; RPS28; RPL18A; UBA52; RPS16; RPS19; RPL18; RPL13A; RPS11; RPS9; RPL28; RPS5; RPL3
R-HSA-72764	Eukaryotic Translation Termination	11.10	0.00e+00	0.000000	78/86	RPL22; RPL11; RPS8; RPL5; RPS27; RPS7; RPS27A; RPL31; RPL37A; RPL32; RPL15; RPSA; RPL14; RPL29; RPL24; RPL22L1; RPL35A; RPL9; RPL34; RPS3A; RPL37; RPS23; RPS14; RPS18; RPS10; RPL10A; RPS12; RPS4X; RPL36A; RPL39; RPL10; RPS20; RPL7; RPL30; RPL8; RPS6; RPL35; RPL12; RPL7A; RPLP2; RPL27A; RPS13; RPS3; RPS25; RPS24; RPL41; RPL6; RPLP0; RPL21; RPS29; RPL4; RPLP1; RPS17; RPS2; RPS15A; RPL13; RPL26; RPL23A; RPL23; RPL19; RPL27; RPL38; RPL17; RPS21; RPS15; RPL36; RPS28; RPL18A; UBA52; RPS16; RPS19; RPL18; RPL13A; RPS11; RPS9; RPL28; RPS5; RPL3
R-HSA-975956	Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)	11.00	0.00e+00	0.000000	79/88	RPL22; RPL11; RPS8; RPL5; RPS27; RPS7; RPS27A; RPL31; RPL37A; RPL32; RPL15; RPSA; RPL14; RPL29; RPL24; RPL22L1; RPL35A; RPL9; RPL34; RPS3A; RPL37; RPS23; RPS14; RPS18; RPS10; RPL10A; RPS12; RPS4X; RPL36A; RPL39; RPL10; RPS20; RPL7; RPL30; PABPC1; RPL8; RPS6; RPL35; RPL12; RPL7A; RPLP2; RPL27A; RPS13; RPS3; RPS25; RPS24; RPL41; RPL6; RPLP0; RPL21; RPS29; RPL4; RPLP1; RPS17; RPS2; RPS15A; RPL13; RPL26; RPL23A; RPL23; RPL19; RPL27; RPL38; RPL17; RPS21; RPS15; RPL36; RPS28; RPL18A; UBA52; RPS16; RPS19; RPL18; RPL13A; RPS11; RPS9; RPL28; RPS5; RPL3
R-HSA-72689	Formation of a pool of free 40S subunits	11.00	0.00e+00	0.000000	85/95	RPL22; RPL11; RPS8; RPL5; RPS27; RPS7; RPS27A; RPL31; RPL37A; RPL32; RPL15; RPSA; RPL14; RPL29; RPL24; RPL22L1; RPL35A; RPL9; RPL34; RPS3A; RPL37; RPS23; RPS14; RPS18; RPS10; RPL10A; RPS12; RPS4X; RPL36A; RPL39; RPL10; RPS20; RPL7; RPL30; EIF3E; EIF3H; RPL8; RPS6; RPL35; RPL12; RPL7A; RPLP2; EIF3F; RPL27A; RPS13; EIF3M; RPS3; RPS25; RPS24; RPL41; RPL6; RPLP0; RPL21; RPS29; RPL4; RPLP1; RPS17; RPS2; RPS15A; RPL13; RPL26; RPL23A; RPL23; RPL19; RPL27; RPL38; RPL17; RPS21; RPS15; RPL36; RPS28; RPL18A; UBA52; EIF3K; RPS16; RPS19; RPL18; RPL13A; RPS11; RPS9; RPL28; RPS5; EIF3D; EIF3L; RPL3
R-HSA-156827	L13a-mediated translational silencing of Ceruloplasmin expression	10.10	0.00e+00	0.000000	87/105	RPL22; RPL11; RPS8; RPL5; RPS27; RPS7; RPS27A; RPL31; RPL37A; RPL32; RPL15; RPSA; RPL14; RPL29; RPL24; RPL22L1; EIF4A2; RPL35A; RPL9; RPL34; RPS3A; RPL37; RPS23; RPS14; RPS18; RPS10; RPL10A; RPS12; RPS4X; RPL36A; RPL39; RPL10; RPS20; RPL7; RPL30; PABPC1; EIF3E; EIF3H; RPL8; RPS6; RPL35; RPL12; RPL7A; RPLP2; EIF3F; RPL27A; RPS13; EIF3M; RPS3; RPS25; RPS24; RPL41; RPL6; RPLP0; RPL21; RPS29; RPL4; RPLP1; RPS17; RPS2; RPS15A; RPL13; RPL26; RPL23A; RPL23; RPL19; RPL27; RPL38; RPL17; RPS21; RPS15; RPL36; RPS28; RPL18A; UBA52; EIF3K; RPS16; RPS19; RPL18; RPL13A; RPS11; RPS9; RPL28; RPS5; EIF3D; EIF3L; RPL3
R-HSA-72706	GTP hydrolysis and joining of the 60S ribosomal subunit	9.94	0.00e+00	0.000000	86/106	RPL22; RPL11; RPS8; RPL5; RPS27; RPS7; RPS27A; RPL31; RPL37A; RPL32; RPL15; RPSA; RPL14; RPL29; RPL24; RPL22L1; EIF4A2; RPL35A; RPL9; RPL34; RPS3A; RPL37; RPS23; RPS14; RPS18; RPS10; RPL10A; RPS12; RPS4X; RPL36A; RPL39; RPL10; RPS20; RPL7; RPL30; EIF3E; EIF3H; RPL8; RPS6; RPL35; RPL12; RPL7A; RPLP2; EIF3F; RPL27A; RPS13; EIF3M; RPS3; RPS25; RPS24; RPL41; RPL6; RPLP0; RPL21; RPS29; RPL4; RPLP1; RPS17; RPS2; RPS15A; RPL13; RPL26; RPL23A; RPL23; RPL19; RPL27; RPL38; RPL17; RPS21; RPS15; RPL36; RPS28; RPL18A; UBA52; EIF3K; RPS16; RPS19; RPL18; RPL13A; RPS11; RPS9; RPL28; RPS5; EIF3D; EIF3L; RPL3
R-HSA-2408522	Selenoamino acid metabolism	9.77	0.00e+00	0.000000	79/99	RPL22; RPL11; RPS8; RPL5; RPS27; RPS7; RPS27A; RPL31; RPL37A; RPL32; RPL15; RPSA; RPL14; QARS; RPL29; RPL24; RPL22L1; RPL35A; RPL9; RPL34; RPS3A; RPL37; RPS23; RPS14; RPS18; RPS10; RPL10A; RPS12; RPS4X; RPL36A; RPL39; RPL10; RPS20; RPL7; RPL30; RPL8; RPS6; RPL35; RPL12; RPL7A; RPLP2; RPL27A; RPS13; RPS3; RPS25; RPS24; RPL41; RPL6; RPLP0; RPL21; RPS29; RPL4; RPLP1; RPS17; RPS2; RPS15A; RPL13; RPL26; RPL23A; RPL23; RPL19; RPL27; RPL38; RPL17; RPS21; RPS15; RPL36; RPS28; RPL18A; UBA52; RPS16; RPS19; RPL18; RPL13A; RPS11; RPS9; RPL28; RPS5; RPL3
R-HSA-1799339	SRP-dependent cotranslational protein targeting to membrane	9.54	0.00e+00	0.000000	81/104	RPL22; RPL11; RPS8; RPL5; RPS27; SRP9; RPS7; RPS27A; RPL31; RPL37A; RPL32; RPL15; RPSA; RPL14; RPL29; RPL24; RPL22L1; RPL35A; RPL9; RPL34; RPS3A; RPL37; RPS23; RPS14; RPS18; RPS10; RPL10A; RPS12; RPS4X; RPL36A; RPL39; SSR4; RPL10; RPS20; RPL7; RPL30; RPL8; RPS6; RPL35; RPL12; RPL7A; RPLP2; RPL27A; RPS13; RPS3; RPS25; RPS24; RPL41; RPL6; RPLP0; RPL21; RPS29; RPL4; RPLP1; RPS17; RPS2; RPS15A; RPL13; RPL26; RPL23A; RPL23; RPL19; RPL27; RPL38; RPL17; RPN2; RPS21; RPS15; RPL36; RPS28; RPL18A; UBA52; RPS16; RPS19; RPL18; RPL13A; RPS11; RPS9; RPL28; RPS5; RPL3
R-HSA-72613	Eukaryotic Translation Initiation	9.54	0.00e+00	0.000000	88/113	RPL22; RPL11; RPS8; RPL5; RPS27; RPS7; RPS27A; RPL31; RPL37A; RPL32; RPL15; RPSA; RPL14; RPL29; RPL24; RPL22L1; EIF4A2; RPL35A; RPL9; RPL34; RPS3A; RPL37; RPS23; RPS14; RPS18; RPS10; RPL10A; RPS12; RPS4X; RPL36A; RPL39; RPL10; EIF4EBP1; RPS20; RPL7; RPL30; PABPC1; EIF3E; EIF3H; RPL8; RPS6; RPL35; RPL12; RPL7A; RPLP2; EIF3F; RPL27A; RPS13; EIF3M; RPS3; RPS25; RPS24; RPL41; RPL6; RPLP0; RPL21; RPS29; RPL4; RPLP1; RPS17; RPS2; RPS15A; RPL13; RPL26; RPL23A; RPL23; RPL19; RPL27; RPL38; RPL17; RPS21; RPS15; RPL36; RPS28; RPL18A; UBA52; EIF3K; RPS16; RPS19; RPL18; RPL13A; RPS11; RPS9; RPL28; RPS5; EIF3D; EIF3L; RPL3
R-HSA-72737	Cap-dependent Translation Initiation	9.54	0.00e+00	0.000000	88/113	RPL22; RPL11; RPS8; RPL5; RPS27; RPS7; RPS27A; RPL31; RPL37A; RPL32; RPL15; RPSA; RPL14; RPL29; RPL24; RPL22L1; EIF4A2; RPL35A; RPL9; RPL34; RPS3A; RPL37; RPS23; RPS14; RPS18; RPS10; RPL10A; RPS12; RPS4X; RPL36A; RPL39; RPL10; EIF4EBP1; RPS20; RPL7; RPL30; PABPC1; EIF3E; EIF3H; RPL8; RPS6; RPL35; RPL12; RPL7A; RPLP2; EIF3F; RPL27A; RPS13; EIF3M; RPS3; RPS25; RPS24; RPL41; RPL6; RPLP0; RPL21; RPS29; RPL4; RPLP1; RPS17; RPS2; RPS15A; RPL13; RPL26; RPL23A; RPL23; RPL19; RPL27; RPL38; RPL17; RPS21; RPS15; RPL36; RPS28; RPL18A; UBA52; EIF3K; RPS16; RPS19; RPL18; RPL13A; RPS11; RPS9; RPL28; RPS5; EIF3D; EIF3L; RPL3
R-HSA-72695	Formation of the ternary complex, and subsequently, the 43S complex	9.44	0.00e+00	0.000000	37/48	RPS8; RPS27; RPS7; RPS27A; RPSA; RPS3A; RPS23; RPS14; RPS18; RPS10; RPS12; RPS4X; RPS20; EIF3E; EIF3H; RPS6; EIF3F; RPS13; EIF3M; RPS3; RPS25; RPS24; RPS29; RPS17; RPS2; RPS15A; RPS21; RPS15; RPS28; EIF3K; RPS16; RPS19; RPS11; RPS9; RPS5; EIF3D; EIF3L
R-HSA-927802	Nonsense-Mediated Decay (NMD)	9.21	0.00e+00	0.000000	79/105	RPL22; RPL11; RPS8; RPL5; RPS27; RPS7; RPS27A; RPL31; RPL37A; RPL32; RPL15; RPSA; RPL14; RPL29; RPL24; RPL22L1; RPL35A; RPL9; RPL34; RPS3A; RPL37; RPS23; RPS14; RPS18; RPS10; RPL10A; RPS12; RPS4X; RPL36A; RPL39; RPL10; RPS20; RPL7; RPL30; PABPC1; RPL8; RPS6; RPL35; RPL12; RPL7A; RPLP2; RPL27A; RPS13; RPS3; RPS25; RPS24; RPL41; RPL6; RPLP0; RPL21; RPS29; RPL4; RPLP1; RPS17; RPS2; RPS15A; RPL13; RPL26; RPL23A; RPL23; RPL19; RPL27; RPL38; RPL17; RPS21; RPS15; RPL36; RPS28; RPL18A; UBA52; RPS16; RPS19; RPL18; RPL13A; RPS11; RPS9; RPL28; RPS5; RPL3
R-HSA-975957	Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)	9.21	0.00e+00	0.000000	79/105	RPL22; RPL11; RPS8; RPL5; RPS27; RPS7; RPS27A; RPL31; RPL37A; RPL32; RPL15; RPSA; RPL14; RPL29; RPL24; RPL22L1; RPL35A; RPL9; RPL34; RPS3A; RPL37; RPS23; RPS14; RPS18; RPS10; RPL10A; RPS12; RPS4X; RPL36A; RPL39; RPL10; RPS20; RPL7; RPL30; PABPC1; RPL8; RPS6; RPL35; RPL12; RPL7A; RPLP2; RPL27A; RPS13; RPS3; RPS25; RPS24; RPL41; RPL6; RPLP0; RPL21; RPS29; RPL4; RPLP1; RPS17; RPS2; RPS15A; RPL13; RPL26; RPL23A; RPL23; RPL19; RPL27; RPL38; RPL17; RPS21; RPS15; RPL36; RPS28; RPL18A; UBA52; RPS16; RPS19; RPL18; RPL13A; RPS11; RPS9; RPL28; RPS5; RPL3
R-HSA-72662	Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S	8.75	0.00e+00	0.000000	40/56	RPS8; RPS27; RPS7; RPS27A; RPSA; EIF4A2; RPS3A; RPS23; RPS14; RPS18; RPS10; RPS12; RPS4X; EIF4EBP1; RPS20; PABPC1; EIF3E; EIF3H; RPS6; EIF3F; RPS13; EIF3M; RPS3; RPS25; RPS24; RPS29; RPS17; RPS2; RPS15A; RPS21; RPS15; RPS28; EIF3K; RPS16; RPS19; RPS11; RPS9; RPS5; EIF3D; EIF3L
R-HSA-72649	Translation initiation complex formation	8.68	0.00e+00	0.000000	39/55	RPS8; RPS27; RPS7; RPS27A; RPSA; EIF4A2; RPS3A; RPS23; RPS14; RPS18; RPS10; RPS12; RPS4X; RPS20; PABPC1; EIF3E; EIF3H; RPS6; EIF3F; RPS13; EIF3M; RPS3; RPS25; RPS24; RPS29; RPS17; RPS2; RPS15A; RPS21; RPS15; RPS28; EIF3K; RPS16; RPS19; RPS11; RPS9; RPS5; EIF3D; EIF3L
R-HSA-168273	Influenza Viral RNA Transcription and Replication	8.67	0.00e+00	0.000000	80/113	RPL22; RPL11; RPS8; RPL5; RPS27; RPS7; RPS27A; RPL31; RPL37A; RPL32; RPL15; RPSA; RPL14; RPL29; RPL24; RPL22L1; RPL35A; RPL9; RPL34; RPS3A; RPL37; RPS23; RPS14; RPS18; RPS10; RPL10A; RPS12; RPS4X; RPL36A; RPL39; RPL10; RPS20; RPL7; RPL30; POLR2K; RPL8; RPS6; RPL35; RPL12; RPL7A; RPLP2; RPL27A; RPS13; RPS3; RPS25; RPS24; RPL41; RPL6; RPLP0; RPL21; RPS29; RPL4; RPLP1; RPS17; RPS2; RPS15A; RPL13; RPL26; RPL23A; RPL23; RPL19; RPL27; RPL38; RPL17; RPS21; RPS15; RPL36; RPS28; RPL18A; UBA52; POLR2I; RPS16; RPS19; RPL18; RPL13A; RPS11; RPS9; RPL28; RPS5; RPL3
R-HSA-72702	Ribosomal scanning and start codon recognition	8.46	0.00e+00	0.000000	38/55	RPS8; RPS27; RPS7; RPS27A; RPSA; EIF4A2; RPS3A; RPS23; RPS14; RPS18; RPS10; RPS12; RPS4X; RPS20; EIF3E; EIF3H; RPS6; EIF3F; RPS13; EIF3M; RPS3; RPS25; RPS24; RPS29; RPS17; RPS2; RPS15A; RPS21; RPS15; RPS28; EIF3K; RPS16; RPS19; RPS11; RPS9; RPS5; EIF3D; EIF3L
R-HSA-168255	Influenza Life Cycle	8.40	0.00e+00	0.000000	83/121	RPL22; RPL11; RPS8; RPL5; RPS27; RPS7; RPS27A; RPL31; RPL37A; RPL32; RPL15; RPSA; RPL14; RPL29; RPL24; RPL22L1; RPL35A; RPL9; RPL34; RPS3A; RPL37; RPS23; RPS14; CANX; RPS18; RPS10; RPL10A; RPS12; RPS4X; RPL36A; RPL39; RPL10; RPS20; RPL7; RPL30; POLR2K; RPL8; RPS6; RPL35; RPL12; RPL7A; RPLP2; RPL27A; RPS13; RPS3; RPS25; RPS24; RPL41; RPL6; RPLP0; RAN; RPL21; RPS29; RPL4; RPLP1; RPS17; RPS2; RPS15A; RPL13; RPL26; RPL23A; RPL23; RPL19; RPL27; RPL38; RPL17; RPS21; RPS15; RPL36; RPS28; CALR; RPL18A; UBA52; POLR2I; RPS16; RPS19; RPL18; RPL13A; RPS11; RPS9; RPL28; RPS5; RPL3
R-HSA-168254	Influenza Infection	8.04	0.00e+00	0.000000	84/128	RPL22; RPL11; RPS8; RPL5; RPS27; RPS7; RPS27A; RPL31; RPL37A; RPL32; RPL15; RPSA; RPL14; RPL29; RPL24; RPL22L1; RPL35A; RPL9; RPL34; RPS3A; RPL37; RPS23; RPS14; CANX; RPS18; RPS10; RPL10A; RPS12; SLC25A6; RPS4X; RPL36A; RPL39; RPL10; RPS20; RPL7; RPL30; POLR2K; RPL8; RPS6; RPL35; RPL12; RPL7A; RPLP2; RPL27A; RPS13; RPS3; RPS25; RPS24; RPL41; RPL6; RPLP0; RAN; RPL21; RPS29; RPL4; RPLP1; RPS17; RPS2; RPS15A; RPL13; RPL26; RPL23A; RPL23; RPL19; RPL27; RPL38; RPL17; RPS21; RPS15; RPL36; RPS28; CALR; RPL18A; UBA52; POLR2I; RPS16; RPS19; RPL18; RPL13A; RPS11; RPS9; RPL28; RPS5; RPL3
R-HSA-9010553	Regulation of expression of SLITs and ROBOs	6.57	0.00e+00	0.000000	80/149	RPL22; RPL11; RPS8; RPL5; RPS27; RPS7; RPS27A; RPL31; RPL37A; RPL32; RPL15; RPSA; RPL14; RPL29; RPL24; RPL22L1; RPL35A; RPL9; RPL34; RPS3A; RPL37; RPS23; RPS14; RPS18; RPS10; RPL10A; RPS12; RPS4X; RPL36A; RPL39; RPL10; RPS20; RPL7; RPL30; PABPC1; RPL8; RPS6; RPL35; RPL12; RPL7A; RPLP2; RPL27A; RPS13; RPS3; RPS25; RPS24; RPL41; RPL6; RPLP0; UBC; RPL21; RPS29; RPL4; RPLP1; RPS17; RPS2; RPS15A; RPL13; RPL26; RPL23A; RPL23; RPL19; RPL27; RPL38; RPL17; RPS21; RPS15; RPL36; RPS28; RPL18A; UBA52; RPS16; RPS19; RPL18; RPL13A; RPS11; RPS9; RPL28; RPS5; RPL3
R-HSA-6791226	Major pathway of rRNA processing in the nucleolus and cytosol	6.44	0.00e+00	0.000000	81/154	RPL22; RPL11; RPS8; RPL5; RPS27; RPS7; RPS27A; RPL31; RPL37A; NCL; RPL32; RPL15; RPSA; RPL14; RPL29; GNL3; RPL24; RPL22L1; RPL35A; RPL9; RPL34; RPS3A; RPL37; RPS23; RPS14; RPS18; RPS10; RPL10A; RPS12; RPS4X; RPL36A; RPL39; RPL10; RPS20; RPL7; RPL30; RPL8; RPS6; RPL35; RPL12; RPL7A; RPLP2; RPL27A; RPS13; RPS3; RPS25; DDX21; RPS24; RPL41; RPL6; RPLP0; RPL21; RPS29; RPL4; RPLP1; RPS17; RPS2; RPS15A; RPL13; RPL26; RPL23A; RPL23; RPL19; RPL27; RPL38; RPL17; RPS21; RPS15; RPL36; RPS28; RPL18A; UBA52; RPS16; RPS19; RPL18; RPL13A; RPS11; RPS9; RPL28; RPS5; RPL3
R-HSA-8868773	rRNA processing in the nucleus and cytosol	6.28	0.00e+00	0.000000	82/160	RPL22; RPL11; RPS8; RPL5; RPS27; RPS7; RPS27A; RPL31; RPL37A; NCL; RPL32; RPL15; RPSA; RPL14; RPL29; GNL3; RPL24; RPL22L1; RPL35A; RPL9; RPL34; RPS3A; RPL37; RPS23; RPS14; NHP2; RPS18; RPS10; RPL10A; RPS12; RPS4X; RPL36A; RPL39; RPL10; RPS20; RPL7; RPL30; RPL8; RPS6; RPL35; RPL12; RPL7A; RPLP2; RPL27A; RPS13; RPS3; RPS25; DDX21; RPS24; RPL41; RPL6; RPLP0; RPL21; RPS29; RPL4; RPLP1; RPS17; RPS2; RPS15A; RPL13; RPL26; RPL23A; RPL23; RPL19; RPL27; RPL38; RPL17; RPS21; RPS15; RPL36; RPS28; RPL18A; UBA52; RPS16; RPS19; RPL18; RPL13A; RPS11; RPS9; RPL28; RPS5; RPL3
R-HSA-72312	rRNA processing	6.12	0.00e+00	0.000000	82/164	RPL22; RPL11; RPS8; RPL5; RPS27; RPS7; RPS27A; RPL31; RPL37A; NCL; RPL32; RPL15; RPSA; RPL14; RPL29; GNL3; RPL24; RPL22L1; RPL35A; RPL9; RPL34; RPS3A; RPL37; RPS23; RPS14; NHP2; RPS18; RPS10; RPL10A; RPS12; RPS4X; RPL36A; RPL39; RPL10; RPS20; RPL7; RPL30; RPL8; RPS6; RPL35; RPL12; RPL7A; RPLP2; RPL27A; RPS13; RPS3; RPS25; DDX21; RPS24; RPL41; RPL6; RPLP0; RPL21; RPS29; RPL4; RPLP1; RPS17; RPS2; RPS15A; RPL13; RPL26; RPL23A; RPL23; RPL19; RPL27; RPL38; RPL17; RPS21; RPS15; RPL36; RPS28; RPL18A; UBA52; RPS16; RPS19; RPL18; RPL13A; RPS11; RPS9; RPL28; RPS5; RPL3
R-HSA-376176	Signaling by ROBO receptors	5.57	0.00e+00	0.000000	81/178	RPL22; RPL11; RPS8; RPL5; RPS27; RPS7; RPS27A; RPL31; RPL37A; RPL32; RPL15; RPSA; RPL14; RPL29; RPL24; RPL22L1; RPL35A; RPL9; RPL34; RPS3A; RPL37; RPS23; RPS14; RPS18; RPS10; RPL10A; RPS12; RPS4X; RPL36A; RPL39; RPL10; RPS20; RPL7; RPL30; PABPC1; RPL8; RPS6; RPL35; RPL12; RPL7A; RPLP2; RPL27A; RPS13; RPS3; RPS25; RPS24; RPL41; RPL6; RPLP0; UBC; RPL21; RPS29; RPL4; RPLP1; RPS17; RPS2; RPS15A; RPL13; PFN1; RPL26; RPL23A; RPL23; RPL19; RPL27; RPL38; RPL17; RPS21; RPS15; RPL36; RPS28; RPL18A; UBA52; RPS16; RPS19; RPL18; RPL13A; RPS11; RPS9; RPL28; RPS5; RPL3
R-HSA-983170	Antigen Presentation: Folding, assembly and peptide loading of class I MHC	5.57	1.07e-03	0.023716	5/11	CANX; HLA-A; HSPA5; PDIA3; CALR
R-HSA-71291	Metabolism of amino acids and derivatives	4.86	0.00e+00	0.000000	83/209	RPL22; RPL11; RPS8; RPL5; PHGDH; RPS27; RPS7; RPS27A; RPL31; RPL37A; RPL32; RPL15; RPSA; RPL14; QARS; RPL29; RPL24; RPL22L1; RPL35A; RPL9; RPL34; RPS3A; RPL37; RPS23; RPS14; RPS18; RPS10; RPL10A; RPS12; SAT1; RPS4X; RPL36A; RPL39; RPL10; RPS20; RPL7; RPL30; RPL8; RPS6; RPL35; RPL12; RPL7A; RPLP2; RPL27A; RPS13; RPS3; RPS25; RPS24; BCAT1; RPL41; RPL6; RPLP0; RPL21; RPS29; RPL4; RPLP1; RPS17; RPS2; RPS15A; RPL13; RPL26; RPL23A; RPL23; RPL19; RPL27; RPL38; PYCR1; RPL17; RPS21; RPS15; RPL36; RPS28; RPL18A; UBA52; RPS16; RPS19; RPL18; RPL13A; RPS11; RPS9; RPL28; RPS5; RPL3
R-HSA-72766	Translation	4.62	0.00e+00	0.000000	97/257	RPL22; RPL11; RPS8; RPL5; RPS27; SRP9; RPS7; RPS27A; RPL31; EEF1B2; RPL37A; RPL32; RPL15; RPSA; RPL14; QARS; RPL29; RPL24; MRPL3; RPL22L1; EIF4A2; RPL35A; RPL9; RPL34; RPS3A; RPL37; RPS23; RPS14; RPS18; RPS10; RPL10A; EEF1A1; RPS12; RPS4X; RPL36A; RPL39; SSR4; RPL10; EIF4EBP1; RPS20; RPL7; RPL30; PABPC1; EIF3E; EIF3H; RPL8; RPS6; RPL35; RPL12; RPL7A; RPLP2; EIF3F; RPL27A; RPS13; EIF3M; RPS3; RPS25; RPS24; RPL41; RPL6; RPLP0; RPL21; RPS29; RPL4; RPLP1; RPS17; RPS2; RPS15A; RPL13; RPL26; RPL23A; RPL23; RPL19; RPL27; RPL38; RPL17; RPN2; RPS21; RPS15; EEF2; RPL36; RPS28; GADD45GIP1; RPL18A; UBA52; EIF3K; RPS16; RPS19; RPL18; RPL13A; RPS11; RPS9; RPL28; RPS5; EIF3D; EIF3L; RPL3
R-HSA-901042	Calnexin/calreticulin cycle	4.59	1.12e-03	0.024031	6/16	RPS27A; CANX; UBC; PDIA3; CALR; UBA52
R-HSA-5663205	Infectious disease	4.19	0.00e+00	0.000000	94/275	RPL22; RPL11; RPS8; RPL5; RPS27; RPS7; CALM2; RPS27A; RPL31; RPL37A; RPL32; RPL15; RPSA; RPL14; RPL29; RPL24; RPL22L1; RPL35A; RPL9; RPL34; RPS3A; RPL37; RPS23; RPS14; NPM1; CANX; RPS18; HMGA1; RPS10; RPL10A; HSP90AB1; RPS12; PPIA; SLC25A6; RPS4X; RPL36A; RPL39; RPL10; RPS20; RPL7; RPL30; POLR2K; RPL8; RPS6; RPL35; RPL12; RPL7A; RPLP2; RPL27A; RPS13; RPS3; RPS25; RPS24; RPL41; SYT1; RPL6; RPLP0; UBC; RAN; RPL21; RPS29; RPL4; RPLP1; RPS17; RPS2; RPS15A; RPL13; VAMP2; RPL26; RPL23A; RPL23; RPL19; RPL27; RPL38; RPL17; RPS21; RPS15; EEF2; RPL36; RPS28; CALR; RPL18A; UBA52; POLR2I; RPS16; RPS19; RPL18; RPL13A; RPS11; RPS9; RPL28; RPS5; RANBP1; RPL3
R-HSA-422475	Axon guidance	3.40	0.00e+00	0.000000	91/328	RPL22; RPL11; RPS8; RPL5; RPS27; ARPC5; RPS7; RPS27A; RPL31; SCN9A; RPL37A; RPL32; RPL15; RPSA; RPL14; RPL29; RPL24; GAP43; RPL22L1; RPL35A; RPL9; RPL34; RPS3A; RPL37; RPS23; DPYSL3; RPS14; RPS18; RPS10; RPL10A; HSP90AB1; RPS12; EZR; RPS4X; RPL36A; DCX; RPL39; RPL10; RPS20; RPL7; RPL30; PABPC1; RPL8; RPS6; RPL35; RPL12; RPL7A; RPLP2; RPL27A; RPS13; CFL1; RPS3; RPS25; RPS24; TUBA1A; RPL41; RPL6; RPLP0; UBC; RPL21; RPS29; RPL4; RPLP1; RPS17; RPS2; RPS15A; RPL13; PFN1; RPL26; RPL23A; RPL23; RPL19; RPL27; RPL38; MYL12A; RPL17; RPS21; RPS15; RPL36; RPS28; RPL18A; UBA52; RPS16; RPS19; RPL18; RPL13A; RPS11; RPS9; RPL28; RPS5; RPL3
R-HSA-381426	Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)	3.24	1.20e-03	0.025223	9/34	PDIA6; IGFBP2; TNC; RCN1; APLP2; HSP90B1; SCG3; CHGB; CST3
R-HSA-114608	Platelet degranulation	3.13	4.78e-04	0.010822	11/43	TAGLN2; CALM2; MANF; PPIA; HSPA5; CFL1; APLP2; SCG3; ALDOA; PFN1; SOD1
R-HSA-76005	Response to elevated platelet cytosolic Ca2+	3.13	4.78e-04	0.010822	11/43	TAGLN2; CALM2; MANF; PPIA; HSPA5; CFL1; APLP2; SCG3; ALDOA; PFN1; SOD1
R-HSA-1643685	Disease	2.69	0.00e+00	0.000000	102/464	RPL22; RPL11; RPS8; PRDX1; JUN; RPL5; SLC16A1; RPS27; RPS7; CALM2; RPS27A; RPL31; RPL37A; RPL32; RPL15; RPSA; RPL14; RPL29; RPL24; RPL22L1; RPL35A; RBPJ; RPL9; RPL34; RPS3A; RPL37; RPS23; RPS14; NPM1; CANX; RPS18; HMGA1; RPS10; RPL10A; HSP90AB1; RPS12; PPIA; SLC25A6; RPS4X; RPL36A; RPL39; RPL10; RPS20; RPL7; RPL30; POLR2K; RPL8; RPS6; RPL35; RPL12; RPL7A; RPLP2; RPL27A; RPS13; BAD; RPS3; RPS25; RPS24; RPL41; SYT1; RPL6; RPLP0; UBC; RAN; RPL21; GPC6; RPS29; RPL4; RPLP1; RPS17; RPS2; RPS15A; RPL13; VAMP2; RPL26; RPL23A; RPL23; RPL19; RPL27; RPL38; RPL17; FKBP1A; RPS21; RPS15; EEF2; RPL36; RPS28; PRDX2; CALR; RPL18A; UBA52; POLR2I; RPS16; RPS19; RPL18; RPL13A; RPS11; RPS9; RPL28; RPS5; RANBP1; RPL3
R-HSA-1266738	Developmental Biology	2.67	0.00e+00	0.000000	97/445	RPL22; RPL11; RPS8; JUN; RPL5; RPS27; ARPC5; H3F3A; RPS7; RPS27A; RPL31; SCN9A; RPL37A; RPL32; RPL15; RPSA; RPL14; RPL29; RPL24; GAP43; RPL22L1; RPL35A; RBPJ; RPL9; H2AFZ; RPL34; RPS3A; RPL37; RPS23; DPYSL3; RPS14; RPS18; RPS10; RPL10A; HSP90AB1; RPS12; EZR; RPS4X; RPL36A; DCX; RPL39; RPL10; RPS20; RPL7; RPL30; POLR2K; PABPC1; RPL8; RPS6; RPL35; RPL12; RPL7A; RPLP2; RPL27A; RPS13; CFL1; RPS3; RPS25; RPS24; TUBA1A; RPL41; RPL6; RPLP0; UBC; RPL21; RPS29; RPL4; RPLP1; RPS17; RPS2; RPS15A; RPL13; PFN1; RPL26; RPL23A; RPL23; RPL19; RPL27; RPL38; MYL12A; RPL17; RPS21; RPS15; RPL36; RPS28; RPL18A; UBA52; POLR2I; RPS16; RPS19; RPL18; RPL13A; RPS11; RPS9; RPL28; RPS5; RPL3
R-HSA-163200	Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.	2.47	3.09e-05	0.000760	23/114	UQCRH; COX7A2L; ATP5G3; NDUFS4; COX7C; NDUFA4; CYCS; NDUFB2; NDUFB11; COX7B; NDUFA1; COX8A; COX6A1; COX5A; NDUFB10; ATP5G1; ATP5A1; ATP5D; COX6B1; MT-ND2; MT-ND3; MT-ND4; MT-CYB
R-HSA-611105	Respiratory electron transport	2.45	1.74e-04	0.004160	19/95	UQCRH; COX7A2L; NDUFS4; COX7C; NDUFA4; CYCS; NDUFB2; NDUFB11; COX7B; NDUFA1; COX8A; COX6A1; COX5A; NDUFB10; COX6B1; MT-ND2; MT-ND3; MT-ND4; MT-CYB
R-HSA-1428517	The citric acid (TCA) cycle and respiratory electron transport	2.40	7.53e-06	0.000191	28/143	UQCRH; SLC16A1; COX7A2L; ATP5G3; NDUFS4; COX7C; VDAC1; NDUFA4; CYCS; NDUFB2; NDUFB11; COX7B; NDUFA1; LDHA; COX8A; LDHB; COX6A1; COX5A; NDUFB10; ATP5G1; ATP5A1; BSG; ATP5D; COX6B1; MT-ND2; MT-ND3; MT-ND4; MT-CYB

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Summary:

Marker	ADNP	ARID1B	ASH1L	CHD2	PTEN	SETD5
Signif_GO_terms	137	59	13	48	46	41