1 Single cell expression data

Source:
Genome-wide CRISPR Screens in Primary Human T Cells Reveal Key Regulators of Immune Function, GEO accession: GSE119450.

Perturbations:
CRISPR knock-out of 20 genes (2 gRNAs per gene) + 8 non-targeting gRNAs. Guide conditions were defined on the target gene level; target genes were either found to regulate T cell responses in the genome-wide screens, or known checkpoint genes.
Guide RNAs were introduced into T cells through a novel procedure called sgRNA lentiviral infection with Cas9 protein electroporation (SLICE).

Cells:
Primary human CD8+ T cells from two healthy donors, with T cell receptor (TCR) stimulation.
Cells from 2 donors were pooled together into 1 analysis. All cells have only a single type of gRNA readout. Quality control resulted in 13983 cells.

Genes:
Top 6000 genes ranked by the multinomial deviance statistics were kept.

Normalization:
Deviance residual transformation.
Batch effect, unique UMI count, library size, and mitochondria percentage were all corrected for. The corrected and scaled expression data were used as input for subsequent factor analysis.

2 Guided results

Here, our "guide", \(G\) matrix, consists of 21 types (20 genes + negative control) of KO conditions across cells.

In each case, Gibbs sampling was conducted for 3000 iterations, and the posterior mean estimates were averaged over the last 1000 iterations.

2.1 SVD Initialization

2.1.1 Local False Sign Rate (LFSR)

For a given GSFA inference result, we can estimate the effect a certain KO condition \(m\) has on the expression of gene \(j\) by computing the LFSR of \(\beta_{m\cdot} \cdot W_{j\cdot}\).

Number of genes that passed GSFA LFSR < 0.05 under each perturbation:
GSFA, # of genes that passed LFSR cutoff of 0.05:
KO ARID1A BTLA C10orf54 CBLB CD3D CD5 CDKN1B
Num_genes 148 0 0 618 281 366 0
KO DGKA DGKZ HAVCR2 LAG3 LCP2 MEF2D NonTarget
Num_genes 0 0 0 0 601 0 0
KO PDCD1 RASA2 SOCS1 STAT6 TCEB2 TMEM222 TNFRSF9
Num_genes 0 153 3 0 323 0 0
Number of genes that passed t-test FDR < 0.05 under each perturbation:
Welch's t-test, # of genes that passed FDR cutoff of 0.05:
KO ARID1A BTLA C10orf54 CBLB CD3D CD5 CDKN1B
Num_genes 14 0 0 15 5 6 1
KO DGKA DGKZ HAVCR2 LAG3 LCP2 MEF2D NonTarget
Num_genes 0 0 0 1 39 0 0
KO PDCD1 RASA2 SOCS1 STAT6 TCEB2 TMEM222 TNFRSF9
Num_genes 0 9 0 5 73 0 1

2.1.2 Estimate of Factor ~ Perturbation Associations (\(\beta\))

2.1.3 Factor ~ KO Posterior Association

2.1.4 Beta PIP vs P-Value

2.1.5 Correlation btw Factors

2.2 Alternative Initializations and Chain Convergence

Other than initializing GSFA using truncated SVD, we also ran 2 chains with random initialization.

2.2.1 Chain mixing and convergence evaluation

Min. 1st Qu. Median Mean 3rd Qu. Max.
ARID1A 0.999 1.01 1.01 1.02 1.03 1.19
BTLA 0.999 1.00 1.01 1.02 1.02 1.40
C10orf54 0.999 1.00 1.00 1.00 1.00 1.01
CBLB 0.999 1.01 1.03 1.05 1.06 1.53
CD3D 0.999 1.02 1.05 1.09 1.12 1.89
CD5 0.999 1.01 1.03 1.04 1.05 1.63
CDKN1B 0.999 1.01 1.02 1.03 1.04 1.22
DGKA 0.999 1.00 1.01 1.01 1.02 1.05
DGKZ 0.999 1.00 1.00 1.01 1.01 1.29
HAVCR2 0.999 1.01 1.01 1.02 1.03 1.10
LAG3 0.999 1.00 1.00 1.00 1.00 1.01
LCP2 0.999 1.01 1.02 1.03 1.03 1.25
MEF2D 0.999 1.00 1.01 1.01 1.01 1.05
NonTarget 0.999 1.00 1.00 1.00 1.00 1.01
PDCD1 0.999 1.00 1.00 1.00 1.00 1.00
RASA2 0.999 1.01 1.01 1.03 1.03 1.67
SOCS1 0.999 1.01 1.02 1.02 1.03 1.22
STAT6 0.999 1.00 1.00 1.00 1.01 1.02
TCEB2 0.999 1.00 1.01 1.02 1.02 1.30
TMEM222 0.999 1.00 1.00 1.01 1.01 1.05
TNFRSF9 0.999 1.00 1.00 1.00 1.00 1.01
offset 0.999 1.00 1.01 1.02 1.02 1.87

2.2.2 Difference btw methods in factor estimation

For a pair of \(Z\) estimations from 2 inference methods, \(Z_1, Z_2\), we quantify the pairwise estimation difference as \(||Z_1Z_1^T - Z_2Z_2^T||_F/N\), where \(||\cdot||\) is the Frobenius norm of a matrix, and \(N\) is the number of rows (samples) in \(Z\).

Guided SVD vs Rand_01: 0.255

Guided SVD vs Rand_02: 0.265

Rand_01 vs Rand_02: 0.276

3 Gene Ontology Enrichment Analysis by Factor

Target genes: Genes w/ non-zero loadings in each factor (PIP cutoff at 0.95);
Backgroud genes: all 6000 genes used in factor analysis;
Statistical test: hypergeometric test (over-representation test);
Only GO terms/pathways that satisfy fold change \(\geq\) 2 and test FDR \(<\) 0.05 are shown below.

3.1 GO Slim Over-Representation Analysis

Gene sets: Gene ontology "Biological Process" (non-redundant).

Factor 1 : 20 significant GO terms
GeneSet description enrichRatio pValue FDR GeneRatio geneSymbols
GO:0051131 chaperone-mediated protein complex assembly 12.50 2.51e-05 2.30e-03 5/12 HSPD1; HSP90AB1; PTGES3; CCT2; HSP90AA1
GO:0045730 respiratory burst 10.00 4.73e-04 2.31e-02 4/12 CD52; PGAM1; CYBA; RPS19
GO:0008334 histone mRNA metabolic process 6.84 6.36e-04 2.91e-02 5/22 SNRPE; SNRPG; SLBP; SNRPF; SNRPB
GO:0006457 protein folding 3.98 4.02e-07 9.82e-05 18/136 PFDN2; HSPD1; HSPE1; CCT5; HSP90AB1; TCP1; CCT6A; PRDX4; HSPA5; FKBP4; PFDN5; PTGES3; CCT2; HSPH1; HSP90AA1; B2M; CALR; PDCD5
GO:0071826 ribonucleoprotein complex subunit organization 3.66 4.30e-08 1.57e-05 23/189 MRPL20; MRTO4; RPS27; SNRPE; SNRPG; HSP90AB1; RPL10; RRS1; BOP1; EIF3F; MRPL11; PTGES3; SNRPF; RPLP0; SRSF9; HSP90AA1; C1QBP; SNRPD1; TXNL4A; SNRPB; RPS19; GLTSCR2; RPL13A
GO:0034504 protein localization to nucleus 3.37 1.69e-05 1.77e-03 16/143 CCT5; FYB; HSP90AB1; TCP1; CCT6A; DKC1; RRS1; TXN; NOLC1; CCT2; RAN; YWHAE; KPNB1; CALR; GLTSCR2; CHCHD10
GO:0022613 ribonucleoprotein complex biogenesis 3.34 1.23e-11 9.04e-09 38/342 MRPL20; MRTO4; ZNF593; EBNA1BP2; RPS27; SNRPE; WDR43; SNRPG; ABCE1; NOP16; NHP2; HSP90AB1; RPL10; DKC1; RRS1; BOP1; RPL35; EIF3F; MRPL11; DDX21; NPM3; NOLC1; PA2G4; PTGES3; SNRPF; RPLP0; SRSF9; RAN; GTF3A; HSP90AA1; C1QBP; SNRPD1; TXNL4A; SNRPB; NOP56; RPS19; GLTSCR2; RPL13A
GO:0032200 telomere organization 3.34 3.93e-04 2.06e-02 11/99 GNL3; CCT5; NHP2; HSP90AB1; TCP1; POLD2; CCT6A; DKC1; PTGES3; CCT2; HSP90AA1
GO:0071897 DNA biosynthetic process 3.22 3.01e-04 1.84e-02 12/112 CCT5; NHP2; HSP90AB1; TCP1; POLD2; CCT6A; DKC1; PTGES3; CCT2; HSP90AA1; PHB; UBA52
GO:0051169 nuclear transport 3.15 7.12e-07 1.31e-04 23/220 ZNF593; SNRPE; SRSF7; SNRPG; SLBP; ABCE1; FYB; HMGA1; HSP90AB1; RRS1; TXN; NOLC1; PA2G4; SNRPF; SRSF9; RAN; YWHAE; EIF5A; KPNB1; SRSF2; SNRPD1; SNRPB; CALR
GO:0017038 protein import 3.09 7.68e-04 3.20e-02 11/107 HSPD1; FYB; HSP90AB1; TXN; NOLC1; RAN; HSP90AA1; KPNB1; TIMM13; PDCD5; TOMM40
GO:0016072 rRNA metabolic process 3.09 9.32e-06 1.37e-03 19/185 MRTO4; EBNA1BP2; RPS27; WDR43; NCL; NHP2; GTF3C6; DKC1; RRS1; BOP1; RPL35; DDX21; NPM3; NOLC1; PA2G4; GTF3A; NOP56; RPS19; GLTSCR2
GO:0006414 translational elongation 3.06 8.31e-04 3.20e-02 11/108 MRPL20; MRPL3; EEF1A1; MRPL17; MRPL11; MRPS34; EIF5A; MRPL12; MRPL4; GADD45GIP1; MRPS12
GO:0009141 nucleoside triphosphate metabolic process 2.99 1.48e-05 1.77e-03 19/191 ENO1; ATP5G3; NDUFS6; CYCS; GIMAP7; TMSB4X; CYC1; STOML2; LDHA; PGAM1; RAN; NDUFAB1; DCTPP1; ATP5G1; NME1; CHCHD10; ATP5J; MT-ND2; MT-CO1
GO:0006403 RNA localization 2.88 1.15e-04 9.33e-03 16/167 ZNF593; SRSF7; SLBP; ABCE1; CCT5; NHP2; TCP1; CCT6A; DKC1; RRS1; PA2G4; CCT2; SRSF9; RAN; EIF5A; SRSF2
GO:0009615 response to virus 2.85 3.55e-04 2.00e-02 14/148 ENO1; PTPRC; ODC1; ABCE1; CCT5; HMGA1; IL2RA; DDX21; TPT1; RPS15A; C1QBP; CCL5; GLTSCR2; POLR3H
GO:0006413 translational initiation 2.82 2.40e-04 1.60e-02 15/160 RPS27; EIF4G1; ABCE1; EIF1AX; RPS4X; RPL10; RPL35; EIF3F; RPLP0; RPS15A; CCL5; UBA52; RPS19; RPL13A; RPL28
GO:0009123 nucleoside monophosphate metabolic process 2.39 9.42e-04 3.45e-02 16/201 ENO1; ATP5G3; PAICS; NDUFS6; CYCS; TMSB4X; CYC1; STOML2; LDHA; PGAM1; NDUFAB1; ATP5G1; CHCHD10; ATP5J; MT-ND2; MT-CO1
GO:0006401 RNA catabolic process 2.38 2.34e-04 1.60e-02 20/253 MRTO4; YBX1; SERBP1; RPS27; EIF4G1; ETF1; SYNCRIP; LSM5; RPS4X; RPL10; DKC1; RPL35; SET; RPLP0; SLIRP; RPS15A; UBA52; RPS19; RPL13A; RPL28
GO:0009259 ribonucleotide metabolic process 2.22 8.21e-04 3.20e-02 19/258 ENO1; ATP5G3; PAICS; NDUFS6; CYCS; GIMAP7; TMSB4X; CYC1; STOML2; LDHA; PGAM1; RAN; NDUFAB1; ATP5G1; NME1; CHCHD10; ATP5J; MT-ND2; MT-CO1
Factor 2 : 54 significant GO terms
GeneSet description enrichRatio pValue FDR GeneRatio geneSymbols
GO:0070972 protein localization to endoplasmic reticulum 8.56 0.00e+00 0.00e+00 75/121 RPL22; RPL11; RPS8; RPL5; RPS27; RPS7; RPS27A; RPL31; RPL37A; RPL32; RPL15; RPSA; RPL14; RPL29; RPL24; RPL35A; RPL9; RPL34; RPS3A; RPL37; RPS23; RPS14; RPS18; RPS10; RPL10A; RPS12; RPS4X; RPL39; RPL10; RPS20; RPL7; RPL30; RPL8; RPS6; RPL35; RPL12; RPL7A; RPLP2; RPL27A; RPS13; RPS3; RPS25; RPS24; RPS26; RPL41; RPL6; RPLP0; RPL21; RPS29; RPL4; RPLP1; RPS17; RPS2; RPS15A; RPL13; RPL26; RPL23A; RPL23; RPL19; RPL27; RPL38; RPS15; RPL36; RPS28; RPL18A; UBA52; RPS16; RPS19; RPL18; RPL13A; RPS11; RPS9; RPL28; RPS5; RPL3
GO:0051383 kinetochore organization 7.99 1.11e-08 3.69e-07 11/19 NUF2; CENPF; CENPA; SMC4; CENPE; CENPK; CENPH; CENPW; SMC2; CENPN; NDC80
GO:0061641 CENP-A containing chromatin organization 7.16 7.22e-10 2.52e-08 14/27 CENPL; CENPA; HJURP; CENPU; CENPK; CENPH; NPM1; CENPW; MIS18BP1; CASC5; OIP5; CENPN; CENPM; MIS18A
GO:0006413 translational initiation 6.82 0.00e+00 0.00e+00 79/160 RPL22; RPL11; RPS8; RPL5; RPS27; RPS7; RPS27A; RPL31; RPL37A; RPL32; RPL15; RPSA; RPL14; RPL29; RPL24; RPL35A; RPL9; RPL34; RPS3A; RPL37; RPS23; RPS14; NPM1; RPS18; RPS10; RPL10A; RPS12; RPS4X; RPL39; RPL10; RPS20; RPL7; RPL30; PABPC1; EIF3E; RPL8; RPS6; RPL35; RPL12; RPL7A; RPLP2; RPL27A; RPS13; RPS3; RPS25; RPS24; RPS26; RPL41; RPL6; RPLP0; RPL21; RPS29; RPL4; RPLP1; RPS17; RPS2; RPS15A; RPL13; RPL26; RPL23A; RPL23; RPL19; RPL27; RPL38; RPS15; RPL36; RPS28; EIF3G; RPL18A; UBA52; RPS16; RPS19; RPL18; RPL13A; RPS11; RPS9; RPL28; RPS5; RPL3
GO:0002181 cytoplasmic translation 5.60 4.44e-16 2.17e-14 30/74 RPL11; RPL31; RPL32; RPL15; RPL29; RPL24; RPL35A; RPL9; RPS23; RPL10A; RPL39; RPL30; EIF3E; RPL8; RPS26; RPL41; RPL6; RPLP0; RPS29; RPLP1; RPL26; RPL19; RPL38; EEF2; RPL36; RPS28; EIF3G; RPL18A; RPL18; RPL13A
GO:0090150 establishment of protein localization to membrane 5.55 0.00e+00 0.00e+00 82/204 RPL22; RPL11; RPS8; RPL5; RPS27; RPS7; SPTBN1; RPS27A; RPL31; RPL37A; RPL32; RPL15; RPSA; RPL14; RPL29; RPL24; RPL35A; RPL9; RPL34; RPS3A; RPL37; RPS23; RPS14; GNB2L1; RPS18; RPS10; RPL10A; RPS12; RPS4X; RPL39; RPL10; RPS20; SDCBP; RPL7; RPL30; RPL8; RPS6; RPL35; RPL12; ZDHHC12; RPL7A; RPLP2; RPL27A; RPS13; RPS3; RPS25; RPS24; RPS26; RPL41; RPL6; RPLP0; RPL21; RPS29; CALM1; RPL4; RPLP1; RPS17; RPS2; RPS15A; ARL6IP1; RPL13; RPL26; RPL23A; RPL23; RPL19; RPL27; RPL38; RPS15; RPL36; RPS28; RPL18A; UBA52; RPS16; RPS19; RPL18; RPL13A; RPS11; RPS9; RPL28; RPS5; YWHAH; RPL3
GO:1902850 microtubule cytoskeleton organization involved in mitosis 5.36 0.00e+00 0.00e+00 33/85 STMN1; CDC20; GPSM2; NUF2; NEK2; CENPA; SPC25; POC1A; TACC3; CENPE; CCNB1; SPDL1; KIFC1; TTK; SMC1A; KIF4A; CDK5RAP2; KIF11; SMC3; RACGAP1; MZT1; NUSAP1; KIF23; PRC1; PLK1; AURKB; TUBG1; NDC80; TPX2; MYBL2; AURKA; SUN2; PCNT
GO:0051321 meiotic cell cycle 5.16 0.00e+00 0.00e+00 37/99 CDC20; NUF2; ASPM; NEK2; MSH6; NCAPH; BUB1; SGOL2; FANCD2; SGOL1; SMC4; MND1; TRIP13; PTTG1; TTK; FBXO5; SMC1A; RAD21; CKS2; SMC2; KIF18A; H2AFX; NCAPD3; SMC3; BUB3; NCAPD2; BRCA2; BUB1B; PKMYT1; PLK1; UBB; TOP2A; TUBG1; CDC25B; AURKA; SUN2; NCAPH2
GO:0007292 female gamete generation 5.05 6.63e-08 1.87e-06 15/41 ASPM; H3F3A; NCAPH; TRIP13; CCNB1; TTK; FBXO5; RPS6; BRCA2; PLK1; UBB; TOP2A; CDC25B; AURKA; NCAPH2
GO:0007059 chromosome segregation 4.94 0.00e+00 0.00e+00 73/204 MAD2L2; SFPQ; CDCA8; CDC20; KIF2C; NUF2; KIF14; NEK2; CENPF; NCAPH; BUB1; SPC25; SGOL2; HJURP; FANCD2; SGOL1; SMC4; ECT2; TACC3; NCAPG; CENPE; MAD2L1; TRIP13; CCNB1; H2AFY; PTTG1; SPDL1; KIFC1; TTK; CENPW; FBXO5; SMC1A; KIF4A; ESCO2; RAD21; SMC2; CDK5RAP2; KIF18A; INCENP; CDCA5; RPS3; NCAPD3; ZWINT; CEP55; SMC3; BUB3; MKI67; NCAPD2; RACGAP1; SKA3; DLGAP5; BUB1B; KNSTRN; CASC5; OIP5; NUSAP1; KIF23; PRC1; PLK1; KIF22; CTCF; CENPN; AURKB; TOP2A; TUBG1; BRCA1; CDC27; SKA2; BIRC5; ANAPC11; NDC80; NCAPH2; MIS18A
GO:0036297 interstrand cross-link repair 4.93 1.41e-05 2.62e-04 10/28 UBE2T; NUCKS1; MSH6; RPS27A; FANCD2; RPA3; RAD51AP1; FANCI; UBB; UBA52
GO:0006401 RNA catabolic process 4.86 0.00e+00 0.00e+00 89/253 RPL22; RPL11; PNRC2; RPS8; RPL5; RPS27; RPS7; RPS27A; XPO1; RPL31; RPL37A; RPL32; LSM3; RPL15; RPSA; RPL14; RPL29; RPL24; RPL35A; RPL9; RPL34; RPS3A; RPL37; RPS23; DCP2; HNRNPA0; RPS14; NPM1; RPS18; RPS10; RPL10A; RPS12; LSM5; RPS4X; RPL39; RPL10; RPS20; RPL7; RPL30; PABPC1; EIF3E; RPL8; RPS6; RPL35; RPL12; RPL7A; RPLP2; RPL27A; RPS13; RNASEH2C; RPS3; RPS25; RPS24; RPS26; RPL41; RPL6; RPLP0; RPL21; RPS29; RPL4; RPLP1; RPS17; RPS2; CARHSP1; RPS15A; RPL13; RPL26; UBB; RPL23A; RPL23; RPL19; RPL27; RPL38; RPS15; RPL36; RPS28; RNASEH2A; RPL18A; LSM4; UBA52; RPS16; RPS19; RPL18; RPL13A; RPS11; RPS9; RPL28; RPS5; RPL3
GO:0007051 spindle organization 4.78 2.22e-16 1.16e-14 36/104 STMN1; CDC20; GPSM2; NUF2; ASPM; NEK2; SPC25; POC1A; TACC3; CENPE; CCNB1; TUBB; KIFC1; TTK; FBXO5; SMC1A; KIF4A; CKAP5; RPS3; KIF11; SMC3; RACGAP1; MZT1; KNSTRN; KIF23; PRC1; PLK1; AURKB; TUBG1; NDC80; TPX2; MYBL2; AURKA; HAUS8; SUN2; PCNT
GO:0006298 mismatch repair 4.60 1.22e-03 1.71e-02 6/18 MSH6; RPA3; HMGB1; PCNA; RNASEH2A; LIG1
GO:0032069 regulation of nuclease activity 4.60 3.17e-03 4.22e-02 5/15 HMGB2; NPM1; RPS3; HMGB1; PCNA
GO:0048285 organelle fission 4.53 0.00e+00 0.00e+00 78/238 MAD2L2; CDCA8; CDC20; KIF2C; NUF2; ASPM; KIF14; NEK2; CENPF; NCAPH; BUB1; SGOL2; FANCD2; SGOL1; RPL24; SMC4; TACC3; NCAPG; CENPE; MAD2L1; CCNA2; MND1; TRIP13; CCNB1; H2AFY; PTTG1; SPDL1; KIFC1; TTK; MTFR2; FBXO5; SMC1A; KIF4A; RAD21; CKS2; SMC2; CDK5RAP2; KIF18A; INCENP; CDCA5; NCAPD3; ZWINT; KIF20B; KIF11; CEP55; SMC3; BUB3; MKI67; NCAPD2; RACGAP1; BRCA2; MZT1; DLGAP5; BUB1B; KNSTRN; NUSAP1; CCNB2; KIF23; PRC1; CCNF; PKMYT1; PLK1; KIF22; AURKB; UBB; TOP2A; TUBG1; CDC27; ANAPC11; NDC80; CDC25B; TPX2; MYBL2; UBE2C; AURKA; PIN1; UBE2S; NCAPH2
GO:0006605 protein targeting 4.39 0.00e+00 0.00e+00 81/255 RPL22; RPL11; RPS8; RPL5; RPS27; RPS7; RPS27A; RPL31; RPL37A; RPL32; RPL15; RPSA; RPL14; RPL29; RPL24; RPL35A; RPL9; RPL34; RPS3A; RPL37; RPS23; RPS14; RPS18; RPS10; RPL10A; RPS12; SLC25A6; RPS4X; RPL39; RPL10; RPS20; SDCBP; RPL7; RPL30; RPL8; RPS6; RPL35; RPL12; ZDHHC12; RPL7A; RPLP2; RPL27A; RPS13; RPS3; RPS25; RPS24; RPS26; RPL41; RPL6; RPLP0; RPL21; RPS29; RPL4; RPLP1; RPS17; RPS2; RPS15A; ARL6IP1; RPL13; RPL26; UBB; RPL23A; RPL23; RPL19; RPL27; RPL38; RPS15; RPL36; RPS28; RPL18A; UBA52; RPS16; RPS19; SAE1; RPL18; RPL13A; RPS11; RPS9; RPL28; RPS5; RPL3
GO:0006333 chromatin assembly or disassembly 4.36 1.20e-12 5.51e-11 30/95 HP1BP3; CENPL; H3F3A; CENPA; HJURP; H1FX; HMGB2; CENPU; CENPK; CENPH; H2AFY; NPM1; HIST1H1A; HIST1H1C; HIST1H1E; HIST1H1D; HIST1H1B; CENPW; ANP32B; H2AFX; HMGB1; MIS18BP1; CASC5; OIP5; HIRIP3; CTCF; CENPN; ASF1B; CENPM; MIS18A
GO:0044839 cell cycle G2/M phase transition 4.32 1.11e-16 6.78e-15 41/131 KIF14; NEK2; CENPF; MSH6; TUBA4A; CEP135; CCNA2; CCNB1; H2AFY; HMMR; NPM1; TUBB; FBXO5; RAD21; MELK; CEP78; CDK5RAP2; CNTRL; ODF2; TUBB4B; CKAP5; CEP57; CDK1; FOXM1; TUBA1A; CENPJ; CALM1; CEP152; CCNB2; PKMYT1; PLK1; AURKB; ATAD5; TUBG1; BRCA1; CDC25B; TPX2; AURKA; HAUS8; GTSE1; PCNT
GO:0009262 deoxyribonucleotide metabolic process 4.25 3.43e-04 5.24e-03 8/26 RRM2; DTYMK; NUDT1; RRM1; UNG; DUT; DCTPP1; TYMS
GO:0034502 protein localization to chromosome 4.21 8.17e-08 2.06e-06 18/59 CENPA; H2AFY; SPDL1; HIST1H1B; TTK; EZH2; ESCO2; RAD21; CDCA5; CDK1; BUB3; BRCA2; BUB1B; CASC5; PLK1; CTCF; AURKB; NDC80
GO:0051653 spindle localization 4.20 8.75e-04 1.26e-02 7/23 GPSM2; ASPM; CENPA; SPDL1; CDK5RAP2; NUSAP1; NDC80
GO:0071103 DNA conformation change 4.17 0.00e+00 0.00e+00 45/149 HP1BP3; CENPL; H3F3A; CENPA; NCAPH; HJURP; H1FX; SMC4; NCAPG; HMGB2; CENPU; CENPK; CCNB1; CENPH; H2AFY; NPM1; HIST1H1A; HIST1H1C; HIST1H1E; HIST1H1D; HIST1H1B; CENPW; HNRNPA2B1; NCAPG2; HMGB3; ANP32B; SMC2; CDCA5; H2AFX; NCAPD3; CDK1; NCAPD2; HMGB1; MIS18BP1; CASC5; OIP5; NUSAP1; PIF1; CTCF; CENPN; TOP2A; ASF1B; CENPM; NCAPH2; MIS18A
GO:0031109 microtubule polymerization or depolymerization 4.06 1.70e-06 3.66e-05 15/51 STMN1; KIF2C; KIF14; FBXO5; CDK5RAP2; KIF18A; CKAP5; RPS3; SKA3; CENPJ; CKAP2; MZT1; TUBG1; SKA2; PIN1
GO:0051302 regulation of cell division 3.98 4.74e-07 1.08e-05 17/59 ASPM; KIF14; ECT2; GNB2L1; E2F8; INCENP; KIF20B; RACGAP1; BRCA2; CALM1; KIF23; PRC1; PLK1; AURKB; CDC25B; AURKA; PIN1
GO:0031023 microtubule organizing center organization 3.87 3.59e-08 1.05e-06 21/75 SASS6; NEK2; XPO1; SGOL1; POC1A; CEP135; NPM1; CDK5RAP2; ODF2; CKAP5; CDK1; KIF11; CENPJ; BRCA2; CEP152; KIAA0101; CCNF; PLK1; BRCA1; AURKA; HAUS8
GO:0050000 chromosome localization 3.84 3.77e-06 7.90e-05 15/54 CDCA8; KIF2C; NUF2; KIF14; CENPF; CENPE; CCNB1; SPDL1; KIFC1; KIF18A; CDCA5; CEP55; DLGAP5; KIF22; NDC80
GO:1904029 regulation of cyclin-dependent protein kinase activity 3.59 3.67e-05 6.41e-04 13/50 CDKN2C; CKS1B; CCNA2; CCNB1; HSP90AB1; ACTB; CKS2; CDKN3; CCNB2; CCNF; PKMYT1; PLK1; CDKN2D
GO:0000910 cytokinesis 3.49 1.27e-07 3.09e-06 22/87 STMN1; KIF14; CENPA; SPTBN1; ECT2; KIF4A; E2F8; INCENP; KIF20B; CEP55; RACGAP1; BRCA2; CKAP2; CALM1; NUSAP1; KIF23; PRC1; PLK1; AURKB; CDC25B; AURKA; PIN1
GO:0071824 protein-DNA complex subunit organization 3.37 4.56e-12 1.86e-10 39/160 HP1BP3; ANP32E; CENPL; CENPF; H3F3A; CENPA; RPS27A; PTMA; HJURP; H1FX; CENPE; HMGB2; CENPU; CENPK; CENPH; H2AFY; NPM1; HIST1H1A; HIST1H1C; HIST1H1E; HIST1H1D; HIST1H1B; CENPW; RPA3; ANP32B; PSMC3; H2AFX; HMGB1; MIS18BP1; CASC5; OIP5; CTCF; CENPN; UBB; RPL23; ASF1B; UBA52; CENPM; MIS18A
GO:0044772 mitotic cell cycle phase transition 3.27 0.00e+00 0.00e+00 72/304 MAD2L2; CDC20; CDKN2C; CKS1B; KIF14; NEK2; CENPF; RRM2; MSH6; BUB1; TUBA4A; RPL24; TACC3; CEP135; CENPE; MAD2L1; CCNA2; TRIP13; CCNB1; HMMR; SPDL1; TUBB; TTK; FBXO5; RPA3; DBF4; EZH2; RAD21; RPS6; MELK; CEP78; CKS2; CDK5RAP2; CNTRL; ODF2; TUBB4B; E2F8; CKAP5; CDCA5; CEP57; CDK1; BUB3; FOXM1; TUBA1A; CENPJ; CDKN3; DLGAP5; CALM1; BUB1B; CEP152; CCNB2; PKMYT1; PLK1; AURKB; RPL26; ATAD5; TUBG1; BRCA1; CDC27; ANAPC11; TYMS; NDC80; CDC25B; PCNA; TPX2; UBE2C; AURKA; CDKN2D; HAUS8; UBE2S; GTSE1; PCNT
GO:1901987 regulation of cell cycle phase transition 3.25 2.22e-16 1.16e-14 56/238 MAD2L2; CDC20; KIF14; NEK2; CENPF; MSH6; BUB1; TUBA4A; CEP135; CENPE; MAD2L1; TRIP13; CCNB1; H2AFY; HMMR; SPDL1; NPM1; TUBB; TTK; FBXO5; EZH2; RAD21; CEP78; CDK5RAP2; CNTRL; ODF2; TUBB4B; E2F8; CKAP5; CDCA5; CEP57; CDK1; BUB3; TUBA1A; CENPJ; DLGAP5; BUB1B; CEP152; PLK1; AURKB; RPL26; ATAD5; TUBG1; BRCA1; CDC27; ANAPC11; NDC80; CDC25B; PCNA; TPX2; UBE2C; AURKA; CDKN2D; HAUS8; GTSE1; PCNT
GO:0045787 positive regulation of cell cycle 3.24 1.28e-12 5.53e-11 43/183 SFPQ; GPSM2; CKS1B; KIF14; POC1A; ECT2; MAD2L1; CCNA2; CCNB1; H2AFY; NPM1; HSP90AB1; FBXO5; EZH2; FGFR1; RAD21; CKS2; E2F8; CDCA5; CDK1; KIF20B; RHNO1; RACGAP1; CENPJ; BRCA2; DLGAP5; NUSAP1; CCNB2; KIF23; CCNF; RPS15A; AURKB; RPL26; ATAD5; RPL23; BRCA1; ANAPC11; NDC80; CDC25B; PCNA; UBE2C; AURKA; GTSE1
GO:0002200 somatic diversification of immune receptors 3.19 1.50e-03 2.07e-02 9/39 MAD2L2; MSH6; POLQ; WHSC1; HMGB2; UNG; HMGB1; ATAD5; LIG1
GO:0032886 regulation of microtubule-based process 3.07 1.41e-06 3.14e-05 22/99 STMN1; GPSM2; NEK2; XPO1; POC1A; TACC3; NPM1; SMC1A; CDK5RAP2; KIF18A; RPS3; KIF11; SMC3; SKA3; CENPJ; CKAP2; CCNF; PLK1; BRCA1; SKA2; TPX2; AURKA
GO:0010948 negative regulation of cell cycle process 3.03 2.46e-10 9.51e-09 38/173 MAD2L2; CDC20; NEK2; CENPF; RRM2; MSH6; BUB1; MAD2L1; TRIP13; CCNB1; H2AFY; PTTG1; SPDL1; NPM1; HSP90AB1; TTK; FBXO5; EZH2; SMC1A; RAD21; CDK5RAP2; E2F8; CDK1; SMC3; BUB3; CBX5; BUB1B; CCNF; PLK1; AURKB; RPL26; RPL23; BRCA1; NDC80; PCNA; AURKA; CDKN2D; GTSE1
GO:0022412 cellular process involved in reproduction in multicellular organism 2.97 7.31e-06 1.45e-04 20/93 ASPM; H3F3A; NCAPH; HMGB2; TRIP13; CCNB1; TTK; FBXO5; RPS6; ODF2; KIF18A; CEP57; BRCA2; CASC5; PLK1; UBB; TOP2A; CDC25B; AURKA; NCAPH2
GO:0022406 membrane docking 2.88 1.21e-05 2.34e-04 20/96 NEK2; TUBA4A; CEP135; SCLT1; TUBB; CEP78; CDK5RAP2; CNTRL; ODF2; TUBB4B; CKAP5; CEP57; CDK1; TUBA1A; CENPJ; CEP152; PLK1; TUBG1; HAUS8; PCNT
GO:0000075 cell cycle checkpoint 2.86 1.45e-07 3.44e-06 29/140 MAD2L2; CDC20; CENPF; MSH6; BUB1; RPL24; MAD2L1; TRIP13; CCNB1; SPDL1; TTK; RPS6; CDK5RAP2; E2F8; H2AFX; ZWINT; CDK1; BUB3; RHNO1; BUB1B; PLK1; AURKB; RPL26; TOP2A; BRCA1; NDC80; PCNA; AURKA; GTSE1
GO:0006310 DNA recombination 2.82 7.73e-08 2.02e-06 31/152 MAD2L2; SFPQ; NUCKS1; MSH6; POLQ; H1FX; WHSC1; MND1; HMGB2; TRIP13; HIST1H1A; HIST1H1C; HIST1H1E; HIST1H1D; HIST1H1B; RPA3; HMGB3; RAD21; H2AFX; RHNO1; RAD51AP1; PARPBP; UNG; HMGB1; BRCA2; PIF1; ATAD5; TOP2A; BRCA1; KPNA2; LIG1
GO:0045930 negative regulation of mitotic cell cycle 2.82 7.73e-08 2.02e-06 31/152 MAD2L2; CDC20; CENPF; MSH6; BUB1; RPL24; MAD2L1; TRIP13; CCNB1; PTTG1; SPDL1; TTK; FBXO5; EZH2; RAD21; RPS6; CDK5RAP2; E2F8; ZWINT; CDK1; BUB3; BUB1B; PLK1; AURKB; RPL26; TOP2A; BRCA1; NDC80; PCNA; AURKA; GTSE1
GO:0033044 regulation of chromosome organization 2.77 3.14e-10 1.15e-08 43/214 MAD2L2; SFPQ; CDC20; NEK2; CENPF; H3F3A; BUB1; H1FX; TACC3; CENPE; MAD2L1; TRIP13; CCNB1; DCP2; H2AFY; PTTG1; SPDL1; HIST1H1A; HIST1H1C; HIST1H1E; HIST1H1D; HIST1H1B; TTK; FBXO5; HNRNPA2B1; RAD21; ATAD2; CDK5RAP2; PHF19; CDCA5; BUB3; MKI67; DLGAP5; BUB1B; PIF1; PLK1; CTCF; AURKB; TOP2A; BRCA1; CDC27; ANAPC11; NDC80
GO:0006338 chromatin remodeling 2.76 1.43e-05 2.62e-04 21/105 ANP32E; CENPL; H3F3A; CENPA; PTMA; HJURP; HMGB2; CENPU; CENPK; CENPH; NPM1; CENPW; ACTB; HMGB3; HMGB1; MIS18BP1; CASC5; OIP5; CENPN; CENPM; MIS18A
GO:0010639 negative regulation of organelle organization 2.65 2.28e-08 7.27e-07 37/193 MAD2L2; STMN1; CDC20; NEK2; CENPF; H3F3A; SPTBN1; BUB1; H1FX; MAD2L1; TRIP13; CCNB1; DCP2; H2AFY; PTTG1; SPDL1; NPM1; HIST1H1A; HIST1H1C; HIST1H1E; HIST1H1D; HIST1H1B; TTK; FBXO5; RAD21; ATAD2; CDK5RAP2; BUB3; CKAP2; BUB1B; PIF1; CCNF; PLK1; AURKB; TOP2A; BRCA1; NDC80
GO:0007018 microtubule-based movement 2.56 1.63e-04 2.72e-03 18/97 SFPQ; KIF2C; KIF14; KIF15; CENPE; KIFC1; KIF4A; WDR34; KIF18A; KIF5B; KIF20B; KIF11; RACGAP1; DLGAP5; KIF23; KIF22; UBB; SUN2
GO:0051052 regulation of DNA metabolic process 2.45 2.70e-08 8.24e-07 42/237 MAD2L2; USP1; NUCKS1; NEK2; MSH6; POLQ; H1FX; WHSC1; CCNA2; DCP2; NPM1; DEK; HIST1H1A; HIST1H1C; HIST1H1E; HIST1H1D; HIST1H1B; HSP90AB1; FBXO5; HNRNPA2B1; DBF4; SMC1A; ESCO2; FGFR1; E2F8; RPS3; H2AFX; CDK1; SMC3; FOXM1; RAD51AP1; PARPBP; UNG; HMGB1; BRCA2; PIF1; AURKB; ATAD5; BRCA1; KPNA2; PCNA; MIS18A
GO:0042770 signal transduction in response to DNA damage 2.42 1.57e-03 2.13e-02 14/80 MAD2L2; CCNB1; E2F8; CDK1; FOXM1; KMT5A; BRCA2; PLK1; RPL26; ATAD5; BRCA1; PCNA; AURKA; GTSE1
GO:0072331 signal transduction by p53 class mediator 2.37 1.04e-04 1.77e-03 22/128 RPL11; RPL5; IFI16; RPS7; CCNB1; E2F8; CDK1; FOXM1; KMT5A; BRCA2; AURKB; RPL26; UBB; ATAD5; RPL23; BRCA1; PCNA; TPX2; AURKA; PIN1; BCL2L12; GTSE1
GO:0071897 DNA biosynthetic process 2.34 3.65e-04 5.45e-03 19/112 MAD2L2; NEK2; CENPF; RPS27A; POLQ; DCP2; HSP90AB1; RPA3; HNRNPA2B1; KIAA0101; PIF1; AURKB; UBB; TK1; TYMS; PCNA; CDKN2D; UBA52; LIG1
GO:2001020 regulation of response to DNA damage stimulus 2.34 2.60e-04 4.14e-03 20/118 MAD2L2; USP1; POLQ; WHSC1; DEK; FBXO5; RPS3; H2AFX; FOXM1; RAD51AP1; PARPBP; KMT5A; HMGB1; TPT1; RPL26; ATAD5; BRCA1; PCNA; CDKN2D; BCL2L12
GO:0071826 ribonucleoprotein complex subunit organization 2.19 2.88e-05 5.14e-04 30/189 RPL11; RPL5; RPS27; LSM3; RPSA; RPL24; RPS23; RPS14; NPM1; RPS10; HSP90AB1; RBMX; RPL10; EIF3E; PSIP1; RPL12; KIF5B; RPL6; RPLP0; RSL24D1; RPL23A; RPL38; RPS15; RPS28; EIF3G; LSM4; RPS19; RPL13A; RPS5; RPL3
GO:0006260 DNA replication 2.12 2.36e-04 3.84e-03 25/163 NUCKS1; RRM2; MSH6; POLQ; CCNA2; FBXO5; RPA3; DBF4; SMC1A; ESCO2; FGFR1; RRM1; E2F8; FAM111A; CDK1; SMC3; BRCA2; DUT; KIAA0101; PIF1; ATAD5; BRCA1; PCNA; RNASEH2A; LIG1
GO:0044782 cilium organization 2.05 8.60e-04 1.26e-02 22/148 NEK2; TUBA4A; POC1A; CEP135; SCLT1; TUBB; CEP78; CDK5RAP2; CNTRL; ODF2; WDR34; TUBB4B; CKAP5; CEP57; CDK1; TUBA1A; CENPJ; CEP152; PLK1; TUBG1; HAUS8; PCNT
GO:0016072 rRNA metabolic process 2.02 3.08e-04 4.81e-03 27/185 RPL11; RPS8; RPL5; RPS27; RPS7; RPSA; RPL14; RPL35A; H2AFY; RPS14; RPL10A; RPL7; RPS6; RPL35; RPL7A; RPS24; RPS17; RPS2; RSL1D1; NOB1; RPL26; RPL27; RPS15; RPS28; RPS16; RPS19; RPS9
Factor 3 : 30 significant GO terms
GeneSet description enrichRatio pValue FDR GeneRatio geneSymbols
GO:0070972 protein localization to endoplasmic reticulum 10.10 0.00e+00 0.00e+00 53/121 RPS8; RPS27; RPS27A; RPL31; RPL37A; RPL32; RPL29; SPCS1; RPL34; RPS3A; RPL37; RPS23; RPS14; RPS18; RPS12; RPS4X; RPL10; RPS20; RPL30; RPL8; RPS6; RPL35; HSPA5; RPL12; RPLP2; RPL27A; RPS13; SPCS2; RPS3; RPL41; RPLP0; RPL21; RPS29; RPLP1; RPS17; RPS2; RPL13; RPL26; RPL23A; RPL19; RPL27; RPL38; RPS21; RPS15; RPL36; RPS28; RPL18A; RPS16; RPS19; RPL18; RPL13A; RPL28; RPL3
GO:1901998 toxin transport 9.19 9.10e-07 7.78e-05 8/20 CCT3; CCT4; CCT7; CCT5; DNAJA1; HSPA5; CCT2; CCT8
GO:0006413 translational initiation 7.90 0.00e+00 0.00e+00 55/160 EIF3I; RPS8; RPS27; RPS27A; RPL31; RPL37A; RPL32; RPL29; RPL34; RPS3A; RPL37; RPS23; RPS14; NPM1; RPS18; RPS12; RPS4X; MCTS1; RPL10; RPS20; RPL30; RPL8; RPS6; RPL35; RPL12; RPLP2; RPL27A; RPS13; POLR2G; RPS3; CDC123; RPL41; RPLP0; RPL21; RPS29; RPLP1; RPS17; RPS2; RPL13; RPL26; RPL23A; RPL19; RPL27; RPL38; RPS21; RPS15; RPL36; RPS28; RPL18A; RPS16; RPS19; RPL18; RPL13A; RPL28; RPL3
GO:0002181 cytoplasmic translation 6.83 1.97e-13 2.41e-11 22/74 EIF3I; RPL31; RPL32; TMA7; RPL29; RPS23; MCTS1; RPL30; RPL8; RPL41; RPLP0; RPS29; RPLP1; RPL26; RPL19; RPL38; RPS21; RPL36; RPS28; RPL18A; RPL18; RPL13A
GO:0070670 response to interleukin-4 5.99 3.44e-04 1.11e-02 6/23 HSP90AB1; IL2RG; HSPA5; TUBA1B; CORO1A; RPL3
GO:0070671 response to interleukin-12 5.91 1.25e-05 6.55e-04 9/35 HSPA9; HNRNPA2B1; PPIA; TALDO1; CFL1; HNRNPF; GSTO1; RPLP0; PSME2
GO:0090150 establishment of protein localization to membrane 5.74 0.00e+00 0.00e+00 51/204 RPS8; RPS27; RPS27A; RPL31; RPL37A; RPL32; RPL29; RPL34; RPS3A; RPL37; RPS23; RPS14; RPS18; RPS12; RPS4X; RPL10; RPS20; RPL30; RPL8; RPS6; RPL35; RPL12; RPLP2; RPL27A; RPS13; RPS3; RPL41; RPLP0; RPL21; RPS29; HSP90AA1; RPLP1; RPS17; RPS2; RPL13; RPL26; RPL23A; RPL19; RPL27; RPL38; RPS21; RPS15; RPL36; RPS28; RPL18A; RPS16; RPS19; RPL18; RPL13A; RPL28; RPL3
GO:0006401 RNA catabolic process 5.63 0.00e+00 0.00e+00 62/253 YBX1; RPS8; MAGOH; RPS27; RPS27A; RPL31; RPL37A; RPL32; RPL29; RPL34; RPS3A; RPL37; RPS23; RPS14; NPM1; RPS18; RPS12; RPS4X; RPL10; RPS20; RPL30; RPL8; RPS6; RPL35; RPL12; SET; RPLP2; RPL27A; RPS13; POLR2G; RPS3; HSPA8; RPL41; RPLP0; UBC; RPL21; HNRNPC; RPS29; RPLP1; RPS17; RPS2; RPL13; RPL26; UBB; RPL23A; RPL19; RPL27; DDX5; RPL38; EIF4A3; RPS21; RPS15; RPL36; RPS28; HNRNPM; RPL18A; RPS16; RPS19; RPL18; RPL13A; RPL28; RPL3
GO:0006605 protein targeting 5.14 0.00e+00 0.00e+00 57/255 RPS8; RPS27; RPS27A; RPL31; RPL37A; RPL32; RPL29; SPCS1; RPL34; RPS3A; RPL37; RPS23; RPS14; RPS18; RPS12; RPS4X; RPL10; RPS20; RPL30; RPL8; RPS6; RPL35; RPL12; RPLP2; RPL27A; RPS13; SPCS2; RPS3; HSPA8; RPL41; RPLP0; UBC; RPL21; RPS29; HSP90AA1; RPLP1; RPS17; RPS2; RPL13; RPL26; UBB; RPL23A; RPL19; RPL27; RPL38; RPS21; RPS15; RPL36; RPS28; RPL18A; ECH1; RPS16; RPS19; RPL18; RPL13A; RPL28; RPL3
GO:0008037 cell recognition 4.97 1.47e-04 5.97e-03 8/37 CCT3; CCT4; CCT7; CCT5; CCT2; ALDOA; CORO1A; CCT8
GO:0009566 fertilization 4.47 7.63e-04 2.00e-02 7/36 CCT3; CCT4; CCT7; CCT5; CCT2; ALDOA; CCT8
GO:0046939 nucleotide phosphorylation 4.38 3.72e-04 1.13e-02 8/42 ENO1; PGK1; LDHA; PGAM1; GAPDH; TPI1; PKM; ALDOA
GO:0006090 pyruvate metabolic process 4.22 2.14e-04 8.24e-03 9/49 ENO1; PGK1; LDHA; PGAM1; GAPDH; TPI1; LDHB; PKM; ALDOA
GO:0009132 nucleoside diphosphate metabolic process 3.75 1.09e-03 2.76e-02 8/49 ENO1; PGK1; LDHA; PGAM1; GAPDH; TPI1; PKM; ALDOA
GO:0071897 DNA biosynthetic process 3.69 1.17e-06 7.78e-05 18/112 CCT3; RPS27A; CCT4; CCT7; XRCC5; CTNNB1; CCT5; HSP90AB1; HNRNPA2B1; PPIA; HNRNPA1; CCT2; UBC; HNRNPC; HSP90AA1; UBB; PCNA; CCT8
GO:0001906 cell killing 3.63 6.91e-04 1.88e-02 9/57 PRDX1; TUBB; HSP90AB1; RPL30; TUBB4B; GAPDH; B2M; CORO1A; RPS19
GO:0032200 telomere organization 3.48 1.96e-05 9.59e-04 15/99 CCT3; CCT4; CCT7; XRCC5; CTNNB1; CCT5; HSP90AB1; HNRNPA2B1; HNRNPA1; CCT2; HNRNPC; HSP90AA1; PCNA; XRCC6; CCT8
GO:0072524 pyridine-containing compound metabolic process 3.43 5.57e-04 1.57e-02 10/67 ENO1; MDH1; PGK1; TALDO1; LDHA; PGAM1; GAPDH; TPI1; PKM; ALDOA
GO:0060249 anatomical structure homeostasis 3.10 1.61e-06 9.86e-05 22/163 PRDX1; CCT3; CCT4; CCT7; XRCC5; CTNNB1; CCT5; HSP90AB1; ACTB; HNRNPA2B1; PGK1; HNRNPA1; CCT2; HNRNPC; HSP90AA1; B2M; ALDOA; CORO1A; ACTG1; PCNA; XRCC6; CCT8
GO:0070646 protein modification by small protein removal 3.07 1.09e-06 7.78e-05 23/172 PSMB2; PSMA5; PSMD4; RPS27A; PSMB8; PSMB9; PSMB1; ACTB; PSMA2; PSMC2; PSMB7; PSMD13; PSMA1; UBC; PSME1; PSME2; PSMA3; PSMA4; PSMB6; UBB; PSMB3; PSMD8; PSMC4
GO:0043687 post-translational protein modification 3.03 4.03e-06 2.27e-04 21/159 PSMB2; PSMA5; PSMD4; SKP1; PSMB8; PSMB9; PSMB1; PSMA2; PSMC2; PSMB7; PSMD13; PSMA1; PSME1; PSME2; PSMA3; PPIB; PSMA4; PSMB6; PSMB3; PSMD8; PSMC4
GO:0006457 protein folding 2.70 2.39e-04 8.76e-03 16/136 CCT3; CCT4; CCT7; CCT5; HSPA9; HSP90AB1; PPIA; DNAJA1; HSPA5; HSPA8; CCT2; HSP90AA1; PDIA3; B2M; PPIB; CCT8
GO:0002446 neutrophil mediated immunity 2.60 9.17e-07 7.78e-05 30/265 CAP1; PSMA5; CD53; ILF2; SELL; PRDX6; XRCC5; TUBB; HSP90AB1; PSMB1; PSMA2; PPIA; PSMC2; ATP6AP2; PSMB7; TUBB4B; PSMD13; HSPA8; PGAM1; CCT2; HSP90AA1; B2M; PKM; ALDOA; CYBA; BST2; GMFG; FTL; XRCC6; CCT8
GO:0036230 granulocyte activation 2.59 9.95e-07 7.78e-05 30/266 CAP1; PSMA5; CD53; ILF2; SELL; PRDX6; XRCC5; TUBB; HSP90AB1; PSMB1; PSMA2; PPIA; PSMC2; ATP6AP2; PSMB7; TUBB4B; PSMD13; HSPA8; PGAM1; CCT2; HSP90AA1; B2M; PKM; ALDOA; CYBA; BST2; GMFG; FTL; XRCC6; CCT8
GO:0009141 nucleoside triphosphate metabolic process 2.53 6.92e-05 2.98e-03 21/191 ENO1; ATP5F1; NDUFS2; ATP5G3; CCNB1; NDUFA4; PGK1; LDHA; HSPA8; ATP5C1; PGAM1; NDUFA9; GAPDH; TPI1; ATP5B; COX6A1; RAN; PKM; ALDOA; ATP5A1; MT-ND1
GO:0010498 proteasomal protein catabolic process 2.34 2.45e-05 1.12e-03 27/265 PSMB2; PSMA5; PSMD4; RPS27A; MAD2L1; CCNB1; SKP1; PSMB8; PSMB9; HSP90AB1; PSMB1; PSMA2; PSMC2; PSMB7; HSPA5; PSMA1; UBC; PSME1; PSME2; PSMA3; PSMA4; PSMB6; UBB; PSMB3; PSMD8; PSMC4; UBE2S
GO:0009123 nucleoside monophosphate metabolic process 2.29 4.04e-04 1.18e-02 20/201 ENO1; ATP5F1; NDUFS2; ATP5G3; CCNB1; NDUFA4; PGK1; LDHA; HSPA8; ATP5C1; PGAM1; NDUFA9; GAPDH; TPI1; ATP5B; COX6A1; PKM; ALDOA; ATP5A1; MT-ND1
GO:1903311 regulation of mRNA metabolic process 2.20 1.24e-03 2.93e-02 18/188 YBX1; MAGOH; PRDX6; RPS27A; CCNB1; NPM1; SRSF3; HNRNPA2B1; HNRNPK; SET; POLR2G; HSPA8; HNRNPA1; UBC; HNRNPC; UBB; DDX5; HNRNPM
GO:0071826 ribonucleoprotein complex subunit organization 2.19 1.32e-03 3.02e-02 18/189 EIF3I; RPS27; RPS23; RPS14; NPM1; HSP90AB1; MCTS1; RPL10; RPL12; RPLP0; HSP90AA1; RPL23A; RPL38; RPS15; RPS28; RPS19; RPL13A; RPL3
GO:0006091 generation of precursor metabolites and energy 2.16 3.48e-04 1.11e-02 23/245 ENO1; ATP5F1; NDUFS2; MDH1; ADH5; CCNB1; PRELID1; NDUFA4; PGK1; COX6C; LDHA; ATP5C1; PGAM1; NDUFA9; GAPDH; TPI1; ATP5B; COX6A1; PKM; ALDOA; CYBA; ATP5A1; MT-ND1
Factor 4 : 101 significant GO terms
GeneSet description enrichRatio pValue FDR GeneRatio geneSymbols
GO:0097066 response to thyroid hormone 5.37 3.60e-04 3.77e-03 6/12 CTSS; ANXA5; CTSB; RDX; ANXA2; EIF5A
GO:0042092 type 2 immune response 5.37 1.17e-03 9.50e-03 5/10 XCL1; NDFIP1; CD74; ANXA1; GATA3
GO:0032612 interleukin-1 production 4.95 1.07e-06 3.02e-05 12/26 GBP5; IFI16; F2R; HAVCR2; HSPB1; ANXA1; CASP1; CARD16; ARRB2; LGALS9; CCL3; CCR7
GO:0050918 positive chemotaxis 4.88 1.98e-03 1.43e-02 5/11 LGALS3; IL16; CORO1A; CCL5; CCL3
GO:0034113 heterotypic cell-cell adhesion 4.69 3.17e-04 3.41e-03 7/16 CD47; FLOT1; PERP; CD44; ITGB1; ITGB7; ITGB2
GO:0070670 response to interleukin-4 4.67 1.68e-05 3.17e-04 10/23 XCL1; LEF1; TCF7; HSP90AB1; IL2RG; HSPA5; GATA3; TUBA1B; CORO1A; XBP1
GO:0032615 interleukin-12 production 4.52 1.61e-04 1.93e-03 8/19 SLAMF1; CD47; TIGIT; LTB; IFNG; ARRB2; LGALS9; CCR7
GO:0033627 cell adhesion mediated by integrin 4.52 1.61e-04 1.93e-03 8/19 ITGB1BP1; CYP1B1; ITGB1; PTPN6; ITGB7; CCL5; ADA; ITGB2
GO:2001057 reactive nitrogen species metabolic process 4.47 2.65e-05 4.22e-04 10/24 ATP2B4; CYP1B1; CD47; AIF1; HSP90AB1; IFNG; GCHFR; RORA; KLF2; ITGB2
GO:0031579 membrane raft organization 4.47 3.13e-03 2.07e-02 5/12 S100A10; MAL; RFTN1; FLOT1; ANXA2
GO:0030101 natural killer cell activation 4.07 2.99e-05 4.67e-04 11/29 PRDX1; PTPN22; SLAMF7; ID2; CASP8; HAVCR2; NCR3; PRDM1; IL21R; CORO1A; ITGB2
GO:0032633 interleukin-4 production 4.02 2.25e-03 1.62e-02 6/16 RBPJ; LEF1; NDFIP1; HAVCR2; GATA3; LGALS9
GO:0032963 collagen metabolic process 3.95 1.09e-03 8.96e-03 7/19 CTSS; F2R; CTSB; CTSD; VIM; ITGB1; ARRB2
GO:0035456 response to interferon-beta 3.95 1.09e-03 8.96e-03 7/19 PYHIN1; IFI16; CAPN2; HTRA2; STAT1; TMEM173; BST2
GO:0001906 cell killing 3.95 1.30e-08 9.52e-07 21/57 PRDX1; SLAMF7; XCL1; GNLY; IL7R; HAVCR2; HLA-F; NCR3; HSP90AB1; RPL30; FAM49B; CTSC; PRF1; LAG3; PTPN6; IFNG; GZMB; B2M; CORO1A; ARRB2; LGALS9
GO:0006959 humoral immune response 3.87 1.05e-05 2.27e-04 13/36 GNLY; RBPJ; CXCL10; HLA-DQB1; RPL30; CD81; CD59; GATA3; PTPN6; IFNG; GPR183; CCR7; BST2
GO:0060326 cell chemotaxis 3.81 2.70e-10 3.30e-08 27/76 RAB13; XCL1; CXCL10; LEF1; ITGA1; CD74; AIF1; HSPB1; FGFR1; ANXA1; CORO1B; JAML; BIN2; GPR183; LGALS3; IL16; CORO1A; CKLF; ARRB2; LGALS9; CCL5; CCL3; CCL3L3; CCL4L2; CCR7; TIAM1; ITGB2
GO:1990868 response to chemokine 3.76 1.54e-03 1.16e-02 7/20 XCL1; CXCL10; CCL5; CCL3; CCL3L3; CCL4L2; CCR7
GO:0043270 positive regulation of ion transport 3.70 1.05e-07 5.15e-06 20/58 PARK7; CTSS; XCL1; ATP1B3; CXCL10; F2R; GLRX; PRELID1; BAK1; FLNA; LGALS3; CALM1; ANXA2; ARRB2; TRPV2; CCL5; CCL3; CCL4L2; SLC9A3R1; ACTN4
GO:0032635 interleukin-6 production 3.67 2.07e-05 3.54e-04 13/38 PTPN22; SLAMF1; CAPN2; INPP5D; CD47; F2R; HAVCR2; PTPN6; CYBA; ARRB2; LGALS9; KLF2; XBP1
GO:0043062 extracellular structure organization 3.64 2.96e-07 1.16e-05 19/56 TNFRSF1B; CTSS; CYP1B1; CFLAR; CD47; ITGA1; FLOT1; FSCN1; SDCBP; CD44; ITGB1; NFKB2; ITGB7; ERO1A; ANXA2; P4HB; SPINT2; ITGB2; COL6A2
GO:0043491 protein kinase B signaling 3.47 8.94e-08 4.68e-06 22/68 PARK7; ITGB1BP1; TRAT1; HSP90AB1; FGFR1; MTDH; TXN; PRKCDBP; SESN3; GATA3; ITGB1; INPP5F; ARRB2; CCL5; CCL3; CCR7; SLC9A3R1; GRB2; MYDGF; SIRT2; GLTSCR2; OSM
GO:0070972 protein localization to endoplasmic reticulum 3.46 8.86e-13 6.50e-10 39/121 RPL11; RPS8; RPL5; RPS27; RPS7; RPS27A; RPL37A; RPL32; RPL15; RPL9; RPL34; RPS3A; SPCS3; RPS23; RPS14; RPL10A; RPL10; RPS20; RPL7; RPL30; RPS6; SEC61B; HSPA5; RPL7A; RPL27A; RPS13; RPS25; RPS24; RPL6; RPL21; RPL4; RPLP1; RPS17; RPS15A; RPL13; RPL23A; RPL23; RPS15; RPS5
GO:0010959 regulation of metal ion transport 3.46 8.42e-10 8.82e-08 29/90 XCL1; ATP2B4; ATP1B3; CXCL10; F2R; GLRX; BAK1; FLNA; SARAF; CHD7; AHNAK; PTPN6; CD63; LGALS3; CALM1; B2M; ANXA2; IL16; CORO1A; CYBA; ARRB2; TRPV2; CCL5; CCL3; CCL4L2; SLC9A3R1; FKBP1A; FXYD5; ACTN4
GO:0003205 cardiac chamber development 3.45 6.75e-04 6.03e-03 9/28 DHRS3; LMO4; ID2; RBPJ; PRDM1; CITED2; CHD7; GATA3; FKBP1A
GO:0072347 response to anesthetic 3.41 2.88e-03 1.95e-02 7/22 DNMT3A; AIF1; HSP90AB1; HSPA5; ADA; TIAM1; MT-ND6
GO:0007187 G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger 3.35 4.39e-04 4.29e-03 10/32 RGS1; ATP2B4; CXCL10; HRH2; FLNA; ANXA1; PTGER2; SLC9A3R1; S1PR4; PTGIR
GO:0071887 leukocyte apoptotic process 3.28 2.22e-05 3.69e-04 15/49 IL7R; CD74; PRELID1; BAK1; RPS6; CDKN2A; ANXA1; IL2RA; CD27; LGALS3; LGALS9; CCL5; CCR7; ADA; HSH2D
GO:0098742 cell-cell adhesion via plasma-membrane adhesion molecules 3.22 7.91e-03 4.67e-02 6/20 SELL; EMB; JAML; ITGB1; FXYD5; ITGB2
GO:0050866 negative regulation of cell activation 3.15 1.20e-05 2.38e-04 17/58 PTPN22; XCL1; ID2; INPP5D; TIGIT; NDFIP1; CD74; HAVCR2; MAD1L1; ANXA1; IL2RA; LAG3; PTPN6; LGALS3; SPN; LGALS9; SAMSN1
GO:0070555 response to interleukin-1 3.15 1.20e-05 2.38e-04 17/58 GBP2; XCL1; RPS27A; CD47; SKP1; ANXA1; NFKBIA; RPS6KA5; RORA; CYBA; LGALS9; CCL5; CCL3; CCL3L3; CCL4L2; AES; KLF2
GO:0050900 leukocyte migration 3.14 1.58e-10 2.66e-08 36/123 XCL1; SELL; GYPC; INPP5D; CD47; ATP1B3; CXCL10; ITGA1; CD74; AIF1; MSN; DOK2; ANXA1; FUT7; CD44; JAML; GATA3; ITGB1; PTPN6; ITGB7; SELPLG; GPR183; LGALS3; IL16; SPN; CORO1A; CKLF; LGALS9; CCL5; CCL3; CCL3L3; CCL4L2; CCR7; GRB2; ADA; ITGB2
GO:0002576 platelet degranulation 3.14 2.38e-04 2.72e-03 12/41 TTN; TUBA4A; TEX264; ANXA5; FAM3C; FLNA; FAM49B; CTSW; SRGN; CD63; CALM1; ACTN4
GO:0048017 inositol lipid-mediated signaling 3.10 1.52e-04 1.89e-03 13/45 F2R; IER3; FGFR1; GATA3; INPP5F; PTPN6; CCL5; SLC9A3R1; MYDGF; HCST; SIRT2; GLTSCR2; OSM
GO:0050920 regulation of chemotaxis 3.07 3.10e-05 4.72e-04 16/56 XCL1; CXCL10; CD74; AIF1; HSPB1; FGFR1; CORO1B; MYCBP2; GPR183; IL16; LGALS9; CCL5; CCL3; CCL4L2; CCR7; TIAM1
GO:0007162 negative regulation of cell adhesion 3.07 3.26e-07 1.16e-05 24/84 PTPN22; XCL1; ITGB1BP1; CYP1B1; TIGIT; NDFIP1; CD74; HAVCR2; MAD1L1; CDKN2A; ANXA1; RDX; IL2RA; LAG3; PTPN6; ARHGDIB; LGALS3; SPN; LGALS9; ARHGDIA; FXYD5; SPINT2; ACTN4; LGALS1
GO:0007229 integrin-mediated signaling pathway 3.02 1.95e-03 1.43e-02 9/32 ITGB1BP1; CD47; ITGA1; FLNA; ITGB1; ITGB7; CD63; LAT; ITGB2
GO:0070371 ERK1 and ERK2 cascade 3.01 8.27e-07 2.42e-05 23/82 PTPN22; SLAMF1; XCL1; ITGB1BP1; CFLAR; F2R; CD74; TNIP1; HAVCR2; FGFR1; PRKCDBP; CD44; PTPN6; GPR183; ARRB2; LGALS9; CCL5; CCL3; CCL3L3; CCL4L2; CCR7; SLC9A3R1; TIAM1
GO:0032103 positive regulation of response to external stimulus 2.99 5.27e-07 1.68e-05 24/86 PARK7; GBP5; XCL1; CD47; CXCL10; CD74; TNIP1; HAVCR2; AIF1; HSPB1; FGFR1; OPTN; NFKBIA; IL16; CYBA; LGALS9; CCL5; CCL3; CCL3L3; CCL4L2; CCR7; OSM; TIAM1; ITGB2
GO:0061448 connective tissue development 2.99 3.88e-04 3.85e-03 12/43 ID2; CFLAR; TBL1XR1; FGFR1; CD44; PLA2G16; CHST11; CRIP1; ANXA2; MAF; XBP1; COL6A2
GO:0034341 response to interferon-gamma 2.90 1.65e-06 4.49e-05 23/85 GBP2; GBP5; XCL1; STAT1; CD47; HLA-F; AIF1; HLA-DRA; HLA-DQA1; HLA-DQB1; HSP90AB1; CD44; CASP1; VIM; IFNG; B2M; MT2A; LGALS9; CCL5; CCL3; CCL3L3; CCL4L2; BST2
GO:0008037 cell recognition 2.90 1.55e-03 1.16e-02 10/37 EMB; HAVCR2; NCR3; MSN; YWHAZ; PRF1; HVCN1; LGALS3; CORO1A; CCR7
GO:0045165 cell fate commitment 2.90 1.55e-03 1.16e-02 10/37 LMO4; ID2; RBPJ; PRDM1; FGFR1; GATA3; ITGB1; RORA; SPN; CYLD
GO:0002237 response to molecule of bacterial origin 2.90 2.13e-07 9.20e-06 27/100 TNFRSF1B; PTPN22; CAPN2; CASP8; CXCL10; HPGD; F2R; HNRNPA0; HAVCR2; MTDH; CASP1; CARD16; IL10RA; VIM; NFKB2; NFKBIA; PTGER2; B2M; LGALS9; CCL5; CCL3; CCR7; JUNB; SIRT2; ZFP36; PTGIR; XBP1
GO:0006413 translational initiation 2.88 5.37e-11 1.31e-08 43/160 RPL11; RPS8; RPL5; RPS27; RPS7; RPS27A; EIF5B; RPL37A; RPL32; RPL15; RPL9; RPL34; RPS3A; RPS23; RPS14; NPM1; RPL10A; HSPB1; RPL10; RPS20; RPL7; RPL30; PABPC1; EIF3E; RPS6; RPL7A; RPL27A; RPS13; RPS25; RPS24; RPL6; RPL21; RPL4; RPLP1; RPS17; RPS15A; RPL13; RPL23A; CCL5; RPL23; EIF1; RPS15; RPS5
GO:0002449 lymphocyte mediated immunity 2.84 3.31e-07 1.16e-05 27/102 TNFRSF1B; PRDX1; SLAMF7; XCL1; CD8A; INPP5D; RFTN1; IL7R; NDFIP1; CD74; HAVCR2; HLA-F; NCR3; HLA-DQB1; FAM49B; CTSC; GATA3; PRF1; CD27; LAG3; PTPN6; KLRD1; GZMB; B2M; CORO1A; ARRB2; LGALS9
GO:0002285 lymphocyte activation involved in immune response 2.79 2.45e-05 4.00e-04 19/73 LEF1; NDFIP1; HAVCR2; HLA-DMB; RPS6; ANXA1; GATA3; APBB1IP; IFNG; GPR183; LGALS3; RORA; SPN; CORO1A; LGALS9; ADA; XBP1; MFNG; LGALS1
GO:0045861 negative regulation of proteolysis 2.77 8.03e-08 4.53e-06 31/120 PARK7; RPL11; IFI6; TMEM59; RPL5; IFI16; RPS7; CFLAR; RYBP; SIAH2; LEF1; CAST; TNFAIP8; PTTG1; SERPINB6; HSP90AB1; NGFRAP1; SDCBP; CD59; CD44; CARD16; DNAJC1; CD27; HERPUD1; ARRB2; RPL23; CST7; CDKN2D; BST2; SPINT2; GLTSCR2
GO:0032609 interferon-gamma production 2.76 3.82e-03 2.46e-02 9/35 PTPN22; XCL1; CD47; HAVCR2; FAM49B; GATA3; SPN; LGALS9; CCR7
GO:0001818 negative regulation of cytokine production 2.74 1.92e-06 4.86e-05 25/98 PTPN22; SLAMF1; XCL1; INPP5D; TIGIT; LEF1; NDFIP1; HAVCR2; HSP90AB1; FGFR1; ANXA1; CARD16; GATA3; SRGN; LAG3; PTPN6; HDAC7; IFNG; RPS6KA5; CYLD; ARRB2; LGALS9; KLF2; BST2; ZFP36
GO:0050663 cytokine secretion 2.73 1.47e-04 1.86e-03 16/63 TNFRSF1B; GBP5; PTPN22; RBPJ; F2R; HAVCR2; ANXA1; CASP1; CARD16; GATA3; SRGN; LGALS9; CCL3; CCR7; XBP1; OSM
GO:0007159 leukocyte cell-cell adhesion 2.72 2.93e-09 2.69e-07 39/154 PTPN22; XCL1; SELL; CD47; TIGIT; IL7R; NDFIP1; CD74; TNIP1; HAVCR2; AIF1; HLA-DMB; MAD1L1; MSN; FAM49B; ANXA1; CD44; IL2RA; GATA3; ITGB1; CD27; LAG3; PTPN6; ITGB7; TESPA1; IFNG; SELPLG; LGALS3; SPN; CORO1A; CYLD; LGALS9; CCL5; CCR7; GRB2; ADA; XBP1; LGALS1; ITGB2
GO:0070661 leukocyte proliferation 2.71 5.91e-07 1.81e-05 28/111 TNFRSF1B; PTPN22; XCL1; INPP5D; LEF1; IL7R; NDFIP1; CD74; HAVCR2; AIF1; HLA-DMB; CCND3; MAD1L1; MSN; RPS6; ANXA1; CD81; IL2RA; PTPN6; GPR183; LGALS3; SPN; CORO1A; LGALS9; CCL5; IKZF3; ADA; CD79A
GO:0034765 regulation of ion transmembrane transport 2.68 1.80e-05 3.30e-04 21/84 PARK7; CTSS; XCL1; ATP2B4; ATP1B3; CXCL10; F2R; GLRX; FLNA; CHD7; AHNAK; PTPN6; CD63; HVCN1; CALM1; CORO1A; CYBA; SLC9A3R1; FKBP1A; FXYD5; ACTN4
GO:2000027 regulation of animal organ morphogenesis 2.68 2.92e-03 1.95e-02 10/40 STAT1; CFLAR; RBPJ; PIM1; CITED2; FGFR1; GATA3; ARRB2; XBP1; TIAM1
GO:0071706 tumor necrosis factor superfamily cytokine production 2.63 8.74e-04 7.63e-03 13/53 PTPN22; SLAMF1; CD47; HAVCR2; HSPB1; PTPN6; IFNG; SPN; CYBA; ARRB2; LGALS9; CCL3; ZFP36
GO:0002250 adaptive immune response 2.63 3.17e-08 1.94e-06 36/147 TNFRSF1B; CTSS; SLAMF1; SLAMF7; XCL1; CD8A; INPP5D; RFTN1; TRAT1; LEF1; IL7R; NDFIP1; CD74; HAVCR2; HLA-F; HLA-DQB1; PRDM1; FAM49B; ANXA1; CTSC; GATA3; PRF1; NFKB2; CD27; PTPN6; IFNG; GPR183; B2M; RORA; LAT; SPN; CD7; ADA; CD79A; LAIR1; SAMSN1
GO:0042110 T cell activation 2.61 2.99e-11 1.10e-08 52/214 TNFRSF1B; PTPN22; XCL1; CD8A; CASP8; CD47; TIGIT; LEF1; IL7R; TCF7; NDFIP1; CD74; HAVCR2; PRELID1; AIF1; HLA-DMB; CCND3; PRDM1; MAD1L1; MSN; CHD7; FAM49B; RPS6; ANXA1; FUT7; JAML; IL2RA; GATA3; APBB1IP; CD27; LAG3; PTPN6; TESPA1; IFNG; GPR183; LGALS3; B2M; RORA; LAT; SPN; CORO1A; CYLD; LGALS9; CCL5; CCR7; GRB2; CD7; FKBP1A; ADA; HSH2D; XBP1; LGALS1
GO:0022407 regulation of cell-cell adhesion 2.60 1.83e-08 1.22e-06 38/157 PTPN22; XCL1; CD47; TIGIT; LEF1; IL7R; NDFIP1; CD74; HAVCR2; FLOT1; AIF1; HLA-DMB; CITED2; MAD1L1; FAM49B; ANXA1; CD44; RDX; IL2RA; GATA3; CD27; LAG3; PTPN6; TESPA1; IFNG; LGALS3; SPN; CORO1A; CYLD; LGALS9; CCL5; CCR7; GRB2; ADA; FXYD5; SPINT2; XBP1; LGALS1
GO:0090150 establishment of protein localization to membrane 2.58 1.82e-10 2.66e-08 49/204 RPL11; RPS8; RPL5; RPS27; SSR2; RPS7; ITGB1BP1; RPS27A; MAL; CASP8; RPL37A; RPL32; RFTN1; RPL15; RPL9; RPL34; RPS3A; RPS23; RPS14; RPL10A; RPL10; RPS20; SDCBP; RPL7; RPL30; YWHAZ; RPS6; SEC61B; RPL7A; RPL27A; RPS13; RPS25; OPTN; RPS24; RPL6; RILPL2; RPL21; GZMB; CALM1; RPL4; RPLP1; RPS17; RPS15A; RPL13; RPL23A; RPL23; RPS15; RPS5; ITGB2
GO:0034764 positive regulation of transmembrane transport 2.57 2.68e-03 1.85e-02 11/46 PARK7; CTSS; XCL1; ATP1B3; CXCL10; F2R; GLRX; FLNA; CALM1; SLC9A3R1; ACTN4
GO:0050727 regulation of inflammatory response 2.55 1.17e-05 2.38e-04 24/101 PARK7; TNFRSF1B; GBP5; XCL1; CD47; TMEM173; NDFIP1; TNIP1; ANXA1; CD81; CD59; IL2RA; GATA3; NFKBIA; RORA; CYLD; CCL5; CCL3; CCL3L3; CCR7; ADA; GPX4; OSM; ITGB2
GO:0034612 response to tumor necrosis factor 2.54 1.84e-05 3.30e-04 23/97 TNFRSF1B; GBP2; XCL1; STAT1; CASP8; LTB; TRAF1; CASP1; CARD16; GATA3; CD27; NFKBIA; RORA; CYLD; CYBA; CCL5; CCL3; CCL3L3; CCL4L2; CD70; KLF2; ACTN4; ZFP36
GO:0009410 response to xenobiotic stimulus 2.52 3.81e-04 3.82e-03 16/68 PHGDH; DNMT3A; CYP1B1; CFLAR; NR3C1; AIF1; HSP90AB1; EPHX2; HSPA5; DDIT4; RGS10; CALM1; RORA; ADA; TIAM1; MT-ND6
GO:0048872 homeostasis of number of cells 2.50 3.19e-06 7.79e-05 28/120 PRDX1; ID2; STAT1; INPP5D; LYAR; IL7R; F2R; CD74; RPS14; SFXN1; BAK1; RPS6; ANXA1; IL2RA; GATA3; RPS24; GPR183; B2M; RPS17; LAT; CORO1A; CYLD; LGALS9; CCR7; ADA; KLF2; ZFP36; PRMT1
GO:0072507 divalent inorganic cation homeostasis 2.48 1.81e-06 4.73e-05 30/130 CD52; XCL1; ATP2B4; CXCL10; ANXA5; F2R; BAK1; TRIM24; P2RY8; EPHX2; CHD7; PTPN6; TPT1; LPAR6; PTGER2; ERO1A; CALM1; ANXA2; CORO1A; MT2A; HERPUD1; CYBA; EIF5A; CCL5; CCL3; CCR7; FKBP1A; S1PR4; PTGIR; SMDT1
GO:0072511 divalent inorganic cation transport 2.48 5.99e-06 1.33e-04 27/117 XCL1; ATP2B4; CXCL10; ANXA5; F2R; BAK1; SARAF; CHD7; AHNAK; PTPN6; TPT1; ERO1A; LGALS3; CALM1; ANXA2; IL16; CORO1A; CYBA; ARRB2; TRPV2; CCL5; CCL3; CCL4L2; CCR7; FKBP1A; KCNN4; SMDT1
GO:0043112 receptor metabolic process 2.48 7.18e-04 6.34e-03 15/65 PARK7; TRAT1; FLOT1; SDCBP; CLTA; HNRNPK; CD81; OPTN; ITGB1; INPP5F; CD63; ANXA2; ARRB2; GRB2; ITGB2
GO:0002521 leukocyte differentiation 2.44 4.39e-09 3.57e-07 46/202 PTPN22; IFI16; BATF3; IRF2BP2; ID2; CD8A; CASP8; INPP5D; RBPJ; LEF1; IL7R; TCF7; NDFIP1; CD74; PRELID1; BAK1; PRDM1; CHD7; RPS6; ANXA1; FUT7; IL2RA; GATA3; ITGB1; FAM213A; CD27; PTPN6; TESPA1; IFNG; GPR183; LGALS3; B2M; ANXA2; RORA; SPN; CYLD; LGALS9; CCL3; IKZF3; CCR7; ADA; JUNB; CD79A; XBP1; MFNG; LGALS1
GO:0071216 cellular response to biotic stimulus 2.40 4.77e-04 4.57e-03 17/76 TNFRSF1B; PTPN22; TXNIP; CAPN2; CXCL10; HAVCR2; MTDH; HSPA5; CASP1; CARD16; VIM; NFKBIA; CCL5; CCL3; SIRT2; ZFP36; XBP1
GO:1901342 regulation of vasculature development 2.37 5.60e-04 5.20e-03 17/77 E2F2; ITGB1BP1; CYP1B1; STAT1; CFLAR; CXCL10; HSPB1; MTDH; ANXA1; ITGB1; HDAC7; PKM; NFATC3; MYDGF; KLF2; XBP1; ITGB2
GO:0042113 B cell activation 2.36 4.52e-05 6.49e-04 24/109 IRF2BP2; ID2; CASP8; INPP5D; RBPJ; LEF1; IL7R; NDFIP1; CD74; BAK1; CD81; ITGB1; CD27; PTPN6; GPR183; CYLD; IKZF3; ADA; BST2; CD79A; XBP1; MFNG; LGALS1; SAMSN1
GO:0072593 reactive oxygen species metabolic process 2.36 9.48e-05 1.24e-03 22/100 PARK7; IFI6; PRDX1; PRDX6; ATP2B4; CYP1B1; CFLAR; CD47; AIF1; HSP90AB1; EPHX2; DDIT4; IFNG; GCHFR; RORA; CYBA; EIF5A; GRB2; KLF2; SIRT2; NCF4; ITGB2
GO:0033002 muscle cell proliferation 2.34 3.95e-03 2.52e-02 12/55 ID2; STAT1; CFLAR; RBPJ; HPGD; AIF1; PIM1; FGFR1; IFNG; CYBA; CCL5; PTGIR
GO:0002064 epithelial cell development 2.32 2.93e-03 1.95e-02 13/60 RAB13; SLC4A7; HRH2; PRDM1; MSN; FLNA; FGFR1; RDX; VIM; RILPL2; SLC9A3R1; SPINT2; XBP1
GO:0038061 NIK/NF-kappaB signaling 2.30 4.62e-03 2.87e-02 12/56 PRDX1; PTPN22; SKP1; HAVCR2; NFKB2; CD27; HDAC7; NFKBIA; CYLD; LGALS9; TRAF4; ACTN4
GO:0097305 response to alcohol 2.29 1.20e-03 9.66e-03 16/75 PMVK; DNMT3A; CASP8; EEF1B2; HPGD; BAK1; GATA3; CD27; PTGER2; CALM1; CYBA; CCL3; CCR7; KLF2; GRAMD1A; MAP4K1
GO:0045785 positive regulation of cell adhesion 2.27 5.80e-06 1.33e-04 32/151 S100A10; XCL1; ITGB1BP1; CD47; IL7R; CD74; HAVCR2; FLOT1; AIF1; HLA-DMB; CITED2; FLNA; FAM49B; ANXA1; CD44; ARL2; IL2RA; GATA3; APBB1IP; CD27; PTPN6; TESPA1; IFNG; CORO1A; CYLD; LGALS9; CCL5; CCR7; GRB2; ADA; XBP1; LGALS1
GO:0032409 regulation of transporter activity 2.23 8.44e-03 4.95e-02 11/53 PARK7; CTSS; ATP1B3; GLRX; NDFIP1; AHNAK; CALM1; SLC9A3R1; FKBP1A; FXYD5; ACTN4
GO:0035821 modification of morphology or physiology of other organism 2.21 4.59e-03 2.87e-02 13/63 GNLY; CASP8; LEF1; TNIP1; RPL30; PRF1; IFNG; CALM1; ANXA2; PPIB; CCL5; CCL3; CCL4L2
GO:0051098 regulation of binding 2.21 5.68e-06 1.33e-04 34/165 PARK7; ID3; RPL11; S100A10; PYHIN1; IFI16; ID2; ITGB1BP1; LEF1; GZMA; TMEM173; FLOT1; BAK1; HSP90AB1; EIF3E; TXN; HSPA5; CARD16; GATA3; IFNG; NFKBIA; LGALS3; CALM1; B2M; ANXA2; CYLD; HERPUD1; ARRB2; TRAF4; FKBP1A; AES; SIRT2; MFNG; TIAM1
GO:0002694 regulation of leukocyte activation 2.21 3.26e-07 1.16e-05 43/209 TNFRSF1B; PTPN22; XCL1; ID2; INPP5D; CD47; TIGIT; IL7R; NDFIP1; CD74; HAVCR2; PRELID1; AIF1; HLA-DMB; PRDM1; MAD1L1; FAM49B; ANXA1; CD81; IL2RA; GATA3; CD27; LAG3; PTPN6; TESPA1; IFNG; GPR183; LGALS3; RORA; LAT; SPN; CORO1A; CYLD; LGALS9; CCL5; IKZF3; CCR7; GRB2; ADA; XBP1; LGALS1; SAMSN1; ITGB2
GO:0003012 muscle system process 2.19 1.02e-03 8.62e-03 18/88 TNFRSF1B; ATP2B4; TTN; CFLAR; MYL5; ITGA1; F2R; AIF1; FLNA; VIM; INPP5F; C12orf57; CALM1; CYBA; MYL12A; ADA; TPM4; TIAM1
GO:0002791 regulation of peptide secretion 2.18 5.18e-05 7.30e-04 28/138 TNFRSF1B; SLC2A1; PTPN22; TTN; PASK; ANXA5; F2R; CD74; HAVCR2; HMGN3; CHD7; ANXA1; ARL2; CASP1; CARD16; GATA3; DNAJC1; SRGN; IFNG; IDH2; LGALS9; CCL5; CCL3; CCR7; KCNN4; XBP1; OSM; TIAM1
GO:0051235 maintenance of location 2.15 3.01e-04 3.29e-03 23/115 PARK7; XCL1; CXCL10; ANXA5; F2R; SKP1; HILPDA; FLNA; CHD7; TXN; HSPA5; ARL2; SRGN; PTPN6; NFKBIA; ERO1A; CALM1; CORO1A; CYBA; CCL3; CCR7; FKBP1A; FTL
GO:0048568 embryonic organ development 2.15 9.94e-04 8.57e-03 19/95 ID3; ID2; NCOA1; CASP8; RBPJ; LEF1; TCF7; PRDM1; CITED2; RPL10; FGFR1; CHD7; GATA3; CHST11; SLC9A3R1; GRB2; ADA; JUNB; SPINT2
GO:0031349 positive regulation of defense response 2.13 3.16e-05 4.72e-04 31/156 PARK7; GBP5; PTPN22; CTSS; PYHIN1; IFI16; RPS27A; CASP8; RFTN1; CD47; TIFA; TMEM173; TNIP1; HAVCR2; FLOT1; NCR3; OPTN; LAG3; NFKBIA; RPS6KA5; CYLD; CYBA; ARRB2; LGALS9; CCL5; CCL3; CCL3L3; CCR7; GLTSCR2; OSM; ITGB2
GO:0002697 regulation of immune effector process 2.13 5.74e-05 7.94e-04 29/146 TNFRSF1B; XCL1; STAT1; CD47; IL7R; TMEM173; NDFIP1; CD74; HAVCR2; HLA-F; NCR3; HLA-DMB; FAM49B; ANXA1; CD81; CD59; IL2RA; GATA3; LAG3; PTPN6; IFNG; LGALS3; B2M; ARRB2; LGALS9; BST2; GLTSCR2; XBP1; ITGB2
GO:0006401 RNA catabolic process 2.12 1.29e-07 5.91e-06 50/253 TNFRSF1B; RPL11; RPS8; RPL5; RPS27; RPS7; RPS27A; RPL37A; RPL32; RPL15; RPL9; RPL34; LSM6; RPS3A; RPS23; HNRNPA0; RPS14; NPM1; RPL10A; ZC3H12D; HSPB1; RPL10; ERI1; RPS20; RPL7; RPL30; PABPC1; YWHAZ; EIF3E; RPS6; RPL7A; RPL27A; RPS13; RPS25; VIM; RPS24; RPL6; RPL21; RPL4; RPLP1; RPS17; ISG20; CARHSP1; RPS15A; RPL13; RPL23A; RPL23; RPS15; ZFP36; RPS5
GO:0006898 receptor-mediated endocytosis 2.12 3.77e-03 2.45e-02 15/76 FLOT1; SDCBP; CLTA; HNRNPK; CD81; ITGB1; INPP5F; M6PR; CD63; B2M; ANXA2; ARRB2; UNC119; GRB2; ITGB2
GO:0050867 positive regulation of cell activation 2.12 8.82e-05 1.18e-03 28/142 XCL1; INPP5D; CD47; IL7R; CD74; HAVCR2; AIF1; HLA-DMB; FAM49B; ANXA1; CD81; IL2RA; GATA3; CD27; PTPN6; TESPA1; IFNG; GPR183; CORO1A; CYLD; LGALS9; CCL5; CCR7; GRB2; ADA; XBP1; LGALS1; ITGB2
GO:0001505 regulation of neurotransmitter levels 2.12 5.11e-03 3.15e-02 14/71 PARK7; PHGDH; ATP2B4; CYP1B1; CD47; FLOT1; AIF1; HSP90AB1; IFNG; CALM1; GCHFR; RORA; KLF2; ITGB2
GO:0009636 response to toxic substance 2.11 1.67e-05 3.17e-04 34/173 PARK7; PRDX1; TXNIP; PRDX6; CAPN2; DNMT3A; CYP1B1; HTRA2; STAT1; CASP8; EEF1B2; HPGD; BAK1; GSTK1; EPHX2; ANXA1; TXN; GATA3; FAM213A; RGS10; CD27; HNRNPA1; ALOX5AP; ESD; CALM1; MT2A; CCL5; CCL3; CCL4L2; ADA; GPX4; KLF2; MPST; MT-ND6
GO:0001819 positive regulation of cytokine production 2.09 3.45e-05 5.06e-04 32/164 PARK7; GBP5; PTPN22; IFI16; XCL1; CYP1B1; STAT1; TIGIT; F2R; TMEM173; CD74; HAVCR2; FLOT1; LTB; HSPB1; HILPDA; FAM49B; ANXA1; CASP1; GATA3; NFKB2; IFNG; B2M; RORA; SPN; CYBA; LGALS9; CCL3; CCR7; GLTSCR2; XBP1; OSM
GO:0003013 circulatory system process 2.07 2.67e-03 1.85e-02 17/88 ATP2B4; ID2; ITGB1BP1; TTN; STAT1; CXCL10; ITGA1; F2R; HRH2; FLNA; EPHX2; CHD7; PTGER2; CALM1; CYBA; SCPEP1; ADA
GO:0031589 cell-substrate adhesion 2.07 2.67e-03 1.85e-02 17/88 S100A10; ITGB1BP1; ITGA1; PRKX; FLNA; CDKN2A; CD44; ARL2; ITGB1; ITGB7; CD63; CORO1A; CCR7; ACTN4; LGALS1; TIAM1; ITGB2
GO:0006605 protein targeting 2.06 4.28e-07 1.43e-05 49/255 RPL11; RPS8; RPL5; RPS27; SSR2; RPS7; ITGB1BP1; RPS27A; HTRA2; RPL37A; RPL32; RPL15; RPL9; RPL34; RPS3A; SPCS3; RPS23; RPS14; RPL10A; GSTK1; RPL10; BNIP3L; EPHX2; RPS20; SDCBP; RPL7; RPL30; YWHAZ; RPS6; SEC61B; RPL7A; RPL27A; RPS13; RPS25; RPS24; M6PR; GNPTAB; RPL6; RPL21; RPL4; RPLP1; RPS17; RPS15A; RPL13; RPL23A; RPL23; RPS15; RPS5; ITGB2
GO:0051346 negative regulation of hydrolase activity 2.06 1.08e-04 1.40e-03 29/151 PARK7; IFI6; IFI16; CFLAR; SIAH2; LEF1; GZMA; IQGAP2; CAST; TNFAIP8; PTTG1; SERPINB6; NGFRAP1; ANXA1; CD44; ARL2; SYTL2; CARD16; RDX; CD27; LGALS3; GCHFR; HERPUD1; ARRB2; FKBP1A; CST7; CDKN2D; BST2; SPINT2
GO:0061458 reproductive system development 2.06 5.72e-04 5.24e-03 23/120 RAB13; NCOA1; CASP8; RBPJ; LEF1; TCF7; BAK1; HSP90AB1; PRDM1; CITED2; FLNA; CTSB; CHD7; RPS6; ANXA1; HSPA5; GATA3; CRIP1; ARRB2; GRB2; ADA; JUNB; SPINT2
GO:0007249 I-kappaB kinase/NF-kappaB signaling 2.04 4.80e-04 4.57e-03 24/126 S100A4; RPS27A; STAT1; CFLAR; CASP8; SHISA5; TIFA; F2R; NDFIP1; CD74; TNIP1; HSPB1; FLNA; MTDH; CASP1; CARD16; OPTN; NFKBIA; RORA; LGALS9; CCR7; FKBP1A; BST2; LGALS1
GO:0030099 myeloid cell differentiation 2.02 7.20e-05 9.78e-04 32/170 IFI16; BATF3; ID2; STAT1; CASP8; INPP5D; GPR171; LYAR; RBPJ; LEF1; NDFIP1; CD74; RPS14; SFXN1; PRKX; RPS6; GATA3; FAM213A; PTPN6; IFNG; GPR183; NFKBIA; LGALS3; B2M; ANXA2; LGALS9; CCL3; CCR7; JUNB; KLF2; ZFP36; PRMT1
Factor 5 : 17 significant GO terms
GeneSet description enrichRatio pValue FDR GeneRatio geneSymbols
GO:0070972 protein localization to endoplasmic reticulum 15.10 0.00e+00 0.00e+00 25/121 RPS8; RPSA; RPL9; RPS3A; RPS18; RPL10A; RPS12; RPL8; RPS6; RPL35; RPL12; RPL7A; RPS3; RPS24; RPLP0; RPS17; RPS2; RPS15; RPL18A; RPS16; RPL13A; RPS9; RPL28; RPS5; RPL3
GO:0006413 translational initiation 12.40 0.00e+00 0.00e+00 27/160 RPS8; RPSA; RPL9; RPS3A; RPS18; RPL10A; RPS12; RPL8; RPS6; RPL35; RPL12; RPL7A; RPS3; RPS24; RPLP0; RPS17; RPS2; CCL5; EIF1; RPS15; RPL18A; RPS16; RPL13A; RPS9; RPL28; RPS5; RPL3
GO:0034109 homotypic cell-cell adhesion 10.50 5.09e-04 2.66e-02 4/28 ACTB; CCL5; ACTG1; LGALS1
GO:0048013 ephrin receptor signaling pathway 9.45 7.58e-04 3.71e-02 4/31 ARPC2; ACTB; ARPC1B; ACTG1
GO:0090150 establishment of protein localization to membrane 8.98 0.00e+00 0.00e+00 25/204 RPS8; RPSA; RPL9; RPS3A; RPS18; RPL10A; RPS12; RPL8; RPS6; RPL35; RPL12; RPL7A; RPS3; RPS24; RPLP0; RPS17; RPS2; RPS15; RPL18A; RPS16; RPL13A; RPS9; RPL28; RPS5; RPL3
GO:0006401 RNA catabolic process 7.53 0.00e+00 0.00e+00 26/253 YBX1; RPS8; RPSA; RPL9; RPS3A; RPS18; RPL10A; RPS12; RPL8; RPS6; RPL35; RPL12; RPL7A; RPS3; RPS24; RPLP0; RPS17; RPS2; RPS15; RPL18A; RPS16; RPL13A; RPS9; RPL28; RPS5; RPL3
GO:0006605 protein targeting 7.18 6.66e-16 9.77e-14 25/255 RPS8; RPSA; RPL9; RPS3A; RPS18; RPL10A; RPS12; RPL8; RPS6; RPL35; RPL12; RPL7A; RPS3; RPS24; RPLP0; RPS17; RPS2; RPS15; RPL18A; RPS16; RPL13A; RPS9; RPL28; RPS5; RPL3
GO:0001906 cell killing 6.43 9.90e-04 4.27e-02 5/57 HMGN2; HLA-E; GAPDH; B2M; CORO1A
GO:0002181 cytoplasmic translation 5.94 4.64e-04 2.62e-02 6/74 RPL9; RPL10A; RPL8; RPLP0; RPL18A; RPL13A
GO:1902903 regulation of supramolecular fiber organization 5.45 3.25e-05 2.97e-03 9/121 STMN1; TMSB10; ARPC2; ARPC1B; TMSB4X; CFL1; RPS3; CORO1A; PFN1
GO:0034341 response to interferon-gamma 5.17 9.74e-04 4.27e-02 6/85 HLA-E; GAPDH; B2M; CCL5; ACTG1; RPL13A
GO:0032970 regulation of actin filament-based process 4.92 1.88e-04 1.25e-02 8/119 STMN1; TMSB10; ARPC2; ARPC1B; TMSB4X; CFL1; CORO1A; PFN1
GO:0051258 protein polymerization 4.92 1.88e-04 1.25e-02 8/119 STMN1; TMSB10; ARPC2; ARPC1B; TMSB4X; RPS3; CORO1A; PFN1
GO:0016072 rRNA metabolic process 4.75 5.74e-06 6.01e-04 12/185 RPS8; RPSA; RPL10A; RPS6; RPL35; RPL7A; RPS24; RPS17; RPS2; RPS15; RPS16; RPS9
GO:0007015 actin filament organization 4.58 3.11e-04 1.90e-02 8/128 STMN1; TMSB10; ARPC2; ARPC1B; TMSB4X; CFL1; CORO1A; PFN1
GO:0022613 ribonucleoprotein complex biogenesis 3.64 2.04e-06 2.49e-04 17/342 RPS8; RPSA; RPL10A; RPS6; RPL35; RPL12; RPL7A; RPS24; RPLP0; RPS17; RPS2; RPS15; RPS16; RPL13A; RPS9; RPS5; RPL3
GO:0034470 ncRNA processing 3.62 8.88e-05 7.23e-03 12/243 RPS8; RPSA; RPL10A; RPS6; RPL35; RPL7A; RPS24; RPS17; RPS2; RPS15; RPS16; RPS9
Factor 6 : 56 significant GO terms
GeneSet description enrichRatio pValue FDR GeneRatio geneSymbols
GO:0022616 DNA strand elongation 11.90 6.94e-08 1.82e-06 8/15 RFC4; GINS4; FEN1; RFC3; GINS2; PCNA; RNASEH2A; LIG1
GO:0006298 mismatch repair 9.94 4.20e-07 1.06e-05 8/18 RPA2; MSH2; MSH6; RPA3; POLD3; PCNA; RNASEH2A; LIG1
GO:0006260 DNA replication 9.47 0.00e+00 0.00e+00 69/163 RPA2; CLSPN; NASP; DTL; RRM2; MSH6; MCM6; BARD1; POLQ; MCM2; RFC4; SLBP; RFC1; GMNN; MCM3; MMS22L; FBXO5; RPA3; RFC2; MCM7; SMC1A; ESCO2; GINS4; MCM4; DSCC1; RMI1; RRM1; E2F8; FAM111A; FEN1; POLA2; POLD3; CHEK1; MCM10; SMC3; MCMBP; CDK2; TIMELESS; PRIM1; RFC5; BRCA2; RFC3; SUPT16H; WDHD1; RAD51; DUT; KIAA0101; PIF1; BLM; RMI2; ORC6; RFWD3; GINS2; CDT1; ATAD5; CDC6; BRCA1; STRA13; RBBP8; PCNA; MCM8; CHAF1A; RNASEH2A; CCNE1; LIG1; CDC45; MCM5; DONSON; CHAF1B
GO:0051383 kinetochore organization 9.42 6.97e-07 1.70e-05 8/19 NUF2; CENPF; CENPA; CENPE; CENPK; SMC2; CDT1; STRA13
GO:0036297 interstrand cross-link repair 8.79 1.23e-08 3.61e-07 11/28 RPA2; UBE2T; MSH6; RPA3; FANCG; RAD51AP1; RAD51; RFWD3; UBB; STRA13; MCM8
GO:0042769 DNA damage response, detection of DNA damage 7.89 1.10e-08 3.35e-07 12/34 RPA2; USP1; DTL; RFC4; RFC1; RPA3; RFC2; POLD3; RFC5; RFC3; UBB; PCNA
GO:0006301 postreplication repair 7.64 1.03e-09 3.60e-08 14/41 RPA2; DTL; MSH2; RFC4; RFC1; RPA3; RFC2; POLD3; RFC5; RFC3; KIAA0101; UBB; BRCA1; PCNA
GO:0051321 meiotic cell cycle 7.00 0.00e+00 0.00e+00 31/99 RPA2; CDC20; NUF2; ASPM; NEK2; MSH6; BUB1; MND1; ING2; PTTG1; FBXO5; FIGNL1; XRCC2; SMC1A; RMI1; CKS2; SMC2; NCAPD3; MASTL; SMC3; CDK2; BRCA2; RAD51; BLM; PKMYT1; PLK1; UBB; STRA13; RBBP8; AURKA; CCNE1
GO:0045023 G0 to G1 transition 6.49 5.19e-06 1.15e-04 9/31 RRM2; EZH2; CHEK1; TFDP1; RAD51; SUZ12; BRCA1; RBBP8; E2F1
GO:0006310 DNA recombination 6.18 0.00e+00 0.00e+00 42/152 RPA2; SFPQ; SMC6; MSH2; MSH6; RIF1; XRCC5; POLQ; MND1; HMGB2; HIST1H1A; HIST1H1C; HIST1H1E; HIST1H1D; HIST1H1B; MMS22L; RPA3; FIGNL1; XRCC2; HMGB3; GINS4; PRKDC; RMI1; FEN1; CHEK1; RAD51AP1; UNG; BRCA2; RAD51; PIF1; BLM; RMI2; RFWD3; GINS2; ATAD5; BRCA1; KPNA2; STRA13; RBBP8; MCM8; LIG1; CDC45
GO:0061641 CENP-A containing chromatin organization 5.80 1.34e-04 2.24e-03 7/27 NASP; CENPA; CENPU; CENPK; CENPP; STRA13; CENPM
GO:0006302 double-strand break repair 5.77 0.00e+00 0.00e+00 33/128 RPA2; SFPQ; SMC6; MSH2; RIF1; BARD1; XRCC5; POLQ; SLF1; DEK; MMS22L; RPA3; FIGNL1; XRCC2; ESCO2; GINS4; PRKDC; RMI1; FEN1; CDCA5; CHEK1; RAD51AP1; TIMELESS; BRCA2; RAD51; BLM; RMI2; RFWD3; GINS2; BRCA1; RBBP8; MCM8; CDC45
GO:0044843 cell cycle G1/S phase transition 5.70 0.00e+00 0.00e+00 38/149 RPA2; NASP; KIF14; RRM2; MCM6; MCM2; CCNB1; DHFR; GMNN; MCM3; FBXO5; RPA3; MCM7; EZH2; EIF4EBP1; PRKDC; MCM4; E2F8; POLA2; MCM10; CDK2; PRIM1; CDK4; TFDP1; CDKN3; ORC6; RFWD3; CDT1; CDC6; TYMS; RBBP8; PCNA; MCM8; E2F1; AURKA; CCNE1; CDC45; MCM5
GO:0071103 DNA conformation change 5.40 0.00e+00 0.00e+00 36/149 RPA2; NASP; CENPA; MCM6; HAT1; XRCC5; MCM2; NCAPG; HMGB2; CENPU; CENPK; CCNB1; HIST1H1A; HIST1H1C; HIST1H1E; HIST1H1D; HIST1H1B; MCM7; HMGB3; GINS4; MCM4; CENPP; SMC2; CDCA5; NCAPD3; HELLS; RAD51; PIF1; BLM; GINS2; STRA13; CHAF1A; ASF1B; CDC45; CENPM; CHAF1B
GO:0006284 base-excision repair 5.37 6.47e-04 9.30e-03 6/25 RPA2; POLQ; RPA3; FEN1; UNG; LIG1
GO:0006333 chromatin assembly or disassembly 5.18 8.43e-11 3.43e-09 22/95 NASP; CENPA; HAT1; MCM2; HMGB2; CENPU; CENPK; HIST1H1A; HIST1H1C; HIST1H1E; HIST1H1D; HIST1H1B; BAZ1B; CENPP; HELLS; SUPT16H; HIRIP3; STRA13; CHAF1A; ASF1B; CENPM; CHAF1B
GO:0002200 somatic diversification of immune receptors 5.16 3.99e-05 7.32e-04 9/39 MSH2; MSH6; RIF1; POLQ; HMGB2; PRKDC; UNG; ATAD5; LIG1
GO:0009262 deoxyribonucleotide metabolic process 5.16 8.10e-04 1.08e-02 6/26 RRM2; RRM1; UNG; DUT; DCTPP1; TYMS
GO:0044839 cell cycle G2/M phase transition 5.12 3.20e-14 1.80e-12 30/131 CLSPN; KIF14; NEK2; DTL; CENPF; MSH6; TOPBP1; CCNB1; HMMR; FBXO5; MELK; CEP78; TUBB4B; CHEK1; MASTL; TUBA1A; CDK2; CDK4; DYNLL1; CEP152; CCNB2; BLM; PKMYT1; PLK1; ATAD5; CDC6; BRCA1; TPX2; AURKA; DONSON
GO:0044772 mitotic cell cycle phase transition 5.00 0.00e+00 0.00e+00 68/304 RPA2; CLSPN; CDC20; NASP; KIF14; NEK2; DTL; CENPF; RRM2; MSH6; BUB1; MCM6; MCM2; TOPBP1; CENPE; CCNB1; DHFR; HMMR; GMNN; MCM3; FBXO5; RPA3; MCM7; EZH2; EIF4EBP1; PRKDC; MCM4; MELK; CEP78; CKS2; TUBB4B; E2F8; CDCA5; POLA2; MCM10; MASTL; TUBA1A; CDK2; PRIM1; CDK4; DYNLL1; TFDP1; CDKN3; DLGAP5; CEP152; CCNB2; BLM; PKMYT1; PLK1; ORC6; RFWD3; CDT1; ATAD5; CDC6; BRCA1; TYMS; RBBP8; PCNA; MCM8; TPX2; E2F1; UBE2C; AURKA; CCNE1; UBE2S; CDC45; MCM5; DONSON
GO:0032200 telomere organization 4.97 2.00e-10 7.71e-09 22/99 RPA2; NEK2; SMC6; RIF1; XRCC5; RFC4; RFC1; RPA3; RFC2; PRKDC; FEN1; POLA2; POLD3; PRIM1; RFC5; BRCA2; RFC3; RAD51; PIF1; BLM; PCNA; CCNE1
GO:0097327 response to antineoplastic agent 4.97 1.44e-04 2.35e-03 8/36 DHFR; EIF4EBP1; TIMELESS; CDK4; RAD51; BLM; BRCA1; PCNA
GO:0034502 protein localization to chromosome 4.93 1.31e-06 3.11e-05 13/59 RPA2; CENPA; MSH2; XRCC5; SLF1; HIST1H1B; EZH2; ESCO2; CDCA5; BRCA2; PLK1; CDT1; MCM8
GO:0007292 female gamete generation 4.91 6.10e-05 1.04e-03 9/41 ASPM; CCNB1; FBXO5; MASTL; BRCA2; PLK1; UBB; MCM8; AURKA
GO:0000075 cell cycle checkpoint 4.79 2.13e-13 1.11e-11 30/140 RPA2; CLSPN; CDC20; DTL; CENPF; MSH2; MSH6; BUB1; TOPBP1; CCNB1; PRKDC; E2F8; RAD9A; CHEK1; ZWINT; CDK2; TIMELESS; TFDP1; WDR76; BLM; PLK1; RFWD3; CDT1; CDC6; BRCA1; PCNA; E2F1; AURKA; CDC45; DONSON
GO:0071897 DNA biosynthetic process 4.79 6.44e-11 2.78e-09 24/112 RPA2; NEK2; DTL; CENPF; XRCC5; POLQ; RFC4; RFC1; RPA3; RFC2; DSCC1; POLA2; POLD3; RFC5; RFC3; TFDP1; KIAA0101; PIF1; BLM; UBB; TK1; TYMS; PCNA; LIG1
GO:0010948 negative regulation of cell cycle process 4.52 1.09e-14 6.65e-13 35/173 RPA2; CLSPN; CDC20; NEK2; DTL; CENPF; RRM2; MSH6; BUB1; TOPBP1; CCNB1; PTTG1; FBXO5; EZH2; SMC1A; PRKDC; E2F8; CHEK1; SMC3; CDK2; CDK4; TFDP1; RAD51; BLM; PLK1; RFWD3; CDT1; SUZ12; CDC6; BRCA1; RBBP8; PCNA; E2F1; AURKA; DONSON
GO:0048285 organelle fission 4.51 0.00e+00 0.00e+00 48/238 RPA2; CDC20; NUF2; ASPM; KIF14; NEK2; CENPF; BUB1; NCAPG; CENPE; MND1; ING2; CCNB1; SLF1; PTTG1; FBXO5; FIGNL1; SMC1A; DSCC1; RMI1; CKS2; SMC2; CDCA5; CHEK1; NCAPD3; MASTL; ZWINT; CEP55; SMC3; BRCA2; DLGAP5; KNSTRN; RAD51; CCNB2; BLM; PKMYT1; PLK1; CDT1; UBB; CDC6; STRA13; TPX2; DSN1; MYBL2; UBE2C; AURKA; CCNE1; UBE2S
GO:1904029 regulation of cyclin-dependent protein kinase activity 4.47 5.56e-05 9.71e-04 10/50 CCNB1; CKS2; CDK4; CDKN3; CCNB2; BLM; PKMYT1; PLK1; CDC6; CCNE1
GO:0045930 negative regulation of mitotic cell cycle 4.41 2.08e-12 1.02e-10 30/152 RPA2; CLSPN; CDC20; CENPF; MSH2; MSH6; BUB1; TOPBP1; CCNB1; PTTG1; FBXO5; EZH2; PRKDC; E2F8; RAD9A; CHEK1; ZWINT; CDK2; TFDP1; BLM; PLK1; RFWD3; CDT1; CDC6; BRCA1; PCNA; E2F1; AURKA; BTG3; DONSON
GO:0007059 chromosome segregation 4.38 3.33e-16 2.44e-14 40/204 SFPQ; CDC20; NUF2; KIF14; NEK2; CENPF; SMC6; BUB1; SPC25; NCAPG; CENPE; CCNB1; SLF1; PTTG1; FBXO5; SMC1A; ESCO2; DSCC1; RMI1; SMC2; FEN1; CDCA5; NCAPD3; ZWINT; CEP55; SMC3; MCMBP; DLGAP5; KNSTRN; BLM; UBE2I; RMI2; PLK1; CDT1; CDC6; BRCA1; BIRC5; STRA13; DSN1; CCNE1
GO:0051052 regulation of DNA metabolic process 4.34 0.00e+00 0.00e+00 46/237 RPA2; USP1; NEK2; MSH2; MSH6; RIF1; XRCC5; POLQ; RFC4; SLF1; DEK; GMNN; HIST1H1A; HIST1H1C; HIST1H1E; HIST1H1D; HIST1H1B; FBXO5; FIGNL1; RFC2; SMC1A; ESCO2; DSCC1; E2F8; CHEK1; SMC3; RAD51AP1; CDK2; TIMELESS; UNG; RFC5; BRCA2; RFC3; TFDP1; RAD51; PIF1; BLM; RMI2; CDT1; ATAD5; CDC6; BRCA1; KPNA2; PCNA; DNMT1; DONSON
GO:0071824 protein-DNA complex subunit organization 4.19 8.35e-12 3.83e-10 30/160 RPA2; NASP; ANP32E; CENPF; CENPA; HAT1; MCM2; CENPE; HMGB2; CENPU; CENPK; GMNN; HIST1H1A; HIST1H1C; HIST1H1E; HIST1H1D; HIST1H1B; RPA3; CENPP; HELLS; SUPT16H; RAD51; CDT1; UBB; STRA13; CHAF1A; ASF1B; CDC45; CENPM; CHAF1B
GO:1901987 regulation of cell cycle phase transition 4.04 4.44e-16 2.96e-14 43/238 RPA2; CLSPN; CDC20; KIF14; NEK2; DTL; CENPF; MSH6; BUB1; TOPBP1; CENPE; CCNB1; HMMR; FBXO5; EZH2; PRKDC; CEP78; TUBB4B; E2F8; CDCA5; CHEK1; TUBA1A; CDK2; CDK4; DYNLL1; TFDP1; DLGAP5; CEP152; BLM; PLK1; RFWD3; CDT1; ATAD5; CDC6; BRCA1; PCNA; TPX2; E2F1; UBE2C; AURKA; CCNE1; CDC45; DONSON
GO:2001020 regulation of response to DNA damage stimulus 3.98 3.65e-08 9.91e-07 21/118 RPA2; USP1; RIF1; POLQ; ING2; SLF1; DEK; FBXO5; FIGNL1; RAD9A; CHEK1; RAD51AP1; TIMELESS; RAD51; WDR76; BLM; RMI2; RFWD3; ATAD5; BRCA1; PCNA
GO:0042770 signal transduction in response to DNA damage 3.91 9.27e-06 2.00e-04 14/80 DTL; CCNB1; PRKDC; E2F8; CHEK1; CDK2; BRCA2; TFDP1; PLK1; ATAD5; BRCA1; PCNA; E2F1; AURKA
GO:0050000 chromosome localization 3.73 5.57e-04 8.34e-03 9/54 NUF2; KIF14; CENPF; CENPE; CCNB1; CDCA5; CEP55; DLGAP5; CDT1
GO:1902850 microtubule cytoskeleton organization involved in mitosis 3.68 1.91e-05 3.89e-04 14/85 STMN1; CDC20; NUF2; NEK2; CENPA; SPC25; CENPE; CCNB1; SMC1A; SMC3; PLK1; TPX2; MYBL2; AURKA
GO:0006289 nucleotide-excision repair 3.68 3.86e-05 7.32e-04 13/79 RPA2; RFC4; RFC1; RPA3; RFC2; POLD3; RFC5; BRCA2; RFC3; UBB; RBBP8; PCNA; LIG1
GO:0000726 non-recombinational repair 3.66 6.41e-04 9.30e-03 9/55 RIF1; BARD1; XRCC5; POLQ; DEK; PRKDC; BLM; BRCA1; RBBP8
GO:0060249 anatomical structure homeostasis 3.57 8.76e-09 2.79e-07 26/163 RPA2; NEK2; SMC6; RIF1; BARD1; XRCC5; RFC4; RFC1; RPA3; RFC2; PRKDC; FEN1; POLA2; POLD3; KRAS; PRIM1; RFC5; BRCA2; RFC3; RAD51; PIF1; BLM; ACTG1; PCNA; CCNE1; RAC2
GO:0045787 positive regulation of cell cycle 3.54 1.31e-09 4.37e-08 29/183 SFPQ; KIF14; DTL; CCNB1; SLF1; FBXO5; EZH2; EIF4EBP1; CKS2; E2F8; FEN1; CDCA5; CHEK1; CDK2; CDK4; BRCA2; TFDP1; DLGAP5; CCNB2; CDT1; ATAD5; CDC6; BRCA1; PCNA; E2F1; UBE2C; AURKA; CCNE1; CDC45
GO:0007051 spindle organization 3.44 1.19e-05 2.49e-04 16/104 STMN1; CDC20; NUF2; ASPM; NEK2; SPC25; CENPE; CCNB1; FBXO5; SMC1A; SMC3; KNSTRN; PLK1; TPX2; MYBL2; AURKA
GO:0051302 regulation of cell division 3.41 1.08e-03 1.42e-02 9/59 ASPM; KIF14; E2F8; BRCA2; BLM; PLK1; ORC6; CDC6; AURKA
GO:0022412 cellular process involved in reproduction in multicellular organism 3.37 5.43e-05 9.70e-04 14/93 ASPM; MSH2; HMGB2; ING2; CCNB1; FBXO5; FIGNL1; FANCG; MASTL; DYNLL1; BRCA2; PLK1; UBB; AURKA
GO:0033044 regulation of chromosome organization 3.34 7.76e-10 2.84e-08 32/214 SFPQ; CDC20; NEK2; CENPF; BUB1; RIF1; XRCC5; MCM2; CENPE; ING2; CCNB1; SLF1; PTTG1; HIST1H1A; HIST1H1C; HIST1H1E; HIST1H1D; HIST1H1B; FBXO5; ATAD2; FEN1; CDCA5; CHEK1; DLGAP5; PIF1; RMI2; PLK1; CDT1; CDC6; BRCA1; DNMT1; CDC45
GO:0072331 signal transduction by p53 class mediator 3.32 3.05e-06 6.98e-05 19/128 E2F2; IFI16; MSH2; ING2; CCNB1; E2F8; TMEM109; CHEK1; CDK2; BRCA2; TFDP1; SUPT16H; UBB; ATAD5; BRCA1; PCNA; TPX2; E2F1; AURKA
GO:0007548 sex differentiation 3.29 7.76e-04 1.05e-02 10/68 NASP; ASPM; MSH2; HMGB2; ING2; FANCG; HSPA5; RRM1; BRCA2; UBB
GO:0031023 microtubule organizing center organization 3.28 4.36e-04 6.66e-03 11/75 NEK2; XRCC2; CHEK1; CDK2; BRCA2; SYNE2; CEP152; KIAA0101; PLK1; BRCA1; AURKA
GO:0009314 response to radiation 3.28 1.56e-08 4.39e-07 28/191 USP1; IFI16; DTL; MSH2; MSH6; XRCC5; TOPBP1; FIGNL1; XRCC2; SMC1A; PRKDC; FANCG; HSPA5; RRM1; TMEM109; FEN1; RAD9A; CHEK1; RAD51AP1; KRAS; BRCA2; RAD51; KIAA0101; BLM; RFWD3; BRCA1; PCNA; ATF4
GO:0040029 regulation of gene expression, epigenetic 2.83 3.19e-05 6.31e-04 19/150 IFI16; RIF1; HAT1; DEK; HIST1H1A; HIST1H1C; HIST1H1E; HIST1H1D; HIST1H1B; BAZ1B; EZH2; ATAD2; CHEK1; HELLS; SUZ12; EIF1; BRCA1; DNMT1; CDC45
GO:0006338 chromatin remodeling 2.77 7.26e-04 1.02e-02 13/105 NASP; ANP32E; CENPA; HMGB2; CENPU; CENPK; BAZ1B; HMGB3; CENPP; CHEK1; HELLS; STRA13; CENPM
GO:0007050 cell cycle arrest 2.75 3.08e-04 4.81e-03 15/122 PPM1G; MSH2; BARD1; CCNB1; EIF4G2; E2F8; CDK2; CDK4; TFDP1; CDKN3; BRCA1; PRR11; PCNA; E2F1; AURKA
GO:0010639 negative regulation of organelle organization 2.55 3.99e-05 7.32e-04 22/193 STMN1; CDC20; NEK2; CENPF; BUB1; XRCC5; MCM2; CCNB1; PTTG1; HIST1H1A; HIST1H1C; HIST1H1E; HIST1H1D; HIST1H1B; FBXO5; ATAD2; CHEK1; PIF1; PLK1; CDT1; BRCA1; DNMT1
GO:0090305 nucleic acid phosphodiester bond hydrolysis 2.50 2.63e-04 4.20e-03 18/161 RPA2; RFC4; RFC1; EXOSC9; HMGB2; RPA3; RFC2; FEN1; RAD9A; POLD3; RFC5; RFC3; POLR3K; UBB; ATAD5; RBBP8; PCNA; RNASEH2A
GO:0097193 intrinsic apoptotic signaling pathway 2.36 7.61e-04 1.05e-02 17/161 E2F2; SFPQ; IFI16; MSH2; MSH6; ING2; FIGNL1; PRKDC; MELK; TMEM109; RAD9A; BRCA2; UBB; ATAD5; BRCA1; E2F1; ATF4
Factor 7 : 87 significant GO terms
GeneSet description enrichRatio pValue FDR GeneRatio geneSymbols
GO:0001773 myeloid dendritic cell activation 8.38 7.47e-06 3.22e-04 7/16 CD2; RBPJ; CAMK4; CSF2; HMGB1; BATF; PYCARD
GO:1990868 response to chemokine 7.66 3.63e-06 1.77e-04 8/20 XCL2; XCL1; FAM65B; CXCR3; CCL1; CCL3; CCL3L3; CCL4L2
GO:0042092 type 2 immune response 7.66 1.19e-03 1.62e-02 4/10 XCL1; NDFIP1; GATA3; BATF
GO:0042490 mechanoreceptor differentiation 6.96 1.79e-03 2.05e-02 4/11 RBPJ; FAM65B; SLC9A3R1; SOD1
GO:0002437 inflammatory response to antigenic stimulus 6.76 1.46e-04 3.14e-03 6/17 PARK7; FCER1G; RBPJ; IL2RA; GATA3; HMGB1
GO:0032613 interleukin-10 production 5.98 1.02e-03 1.41e-02 5/16 FCER1G; XCL1; TIGIT; HMGB1; PYCARD
GO:0032633 interleukin-4 production 5.98 1.02e-03 1.41e-02 5/16 FCER1G; RBPJ; LEF1; NDFIP1; GATA3
GO:0034113 heterotypic cell-cell adhesion 5.98 1.02e-03 1.41e-02 5/16 LCK; CD58; CD2; ITGA4; CD44
GO:0061053 somite development 5.47 4.80e-03 4.29e-02 4/14 ZEB2; BHLHE40; RBPJ; LEF1
GO:0050663 cytokine secretion 4.86 7.80e-08 6.35e-06 16/63 TNFRSF4; CD58; CD2; SPTBN1; SELK; RBPJ; PTGER4; CRTAM; GATA3; SRGN; HMGB1; RGCC; SOCS1; PYCARD; CCL1; CCL3
GO:0007187 G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger 4.79 1.75e-04 3.54e-03 8/32 RGS1; RAMP1; PTGER4; HRH2; SLC9A3R1; S1PR4; ADGRE5; PTGIR
GO:0002065 columnar/cuboidal epithelial cell differentiation 4.59 1.46e-03 1.77e-02 6/25 RBPJ; LEF1; FAM65B; CDK6; SLC9A3R1; SOD1
GO:0050900 leukocyte migration 4.36 1.42e-11 1.04e-08 28/123 TNFRSF18; LCK; CD58; CD2; FCER1G; XCL2; XCL1; SELL; LYST; GYPC; ITGA4; SELK; PTGER4; FAM65B; FYN; CXCR3; CD44; GATA3; SELPLG; HMGB1; CORO1A; PYCARD; CCL1; CCL3; CCL3L3; CCL4L2; ADA; TNFSF14
GO:0034612 response to tumor necrosis factor 4.34 2.65e-09 6.47e-07 22/97 TNFRSF18; TNFRSF4; TNFRSF9; CD58; XCL2; XCL1; ZFP36L2; LTB; TRAF1; BIRC3; GATA3; NFKBIA; ZFP36L1; PYCARD; CYBA; CCL1; CCL3; CCL3L3; CCL4L2; CD70; TNFSF14; KLF2
GO:0070371 ERK1 and ERK2 cascade 4.20 1.34e-07 9.84e-06 18/82 JUN; XCL2; XCL1; ZFP36L2; CFLAR; PTGER4; DUSP4; PRKCDBP; CD44; HMGB1; ZFP36L1; CTSH; PYCARD; CCL1; CCL3; CCL3L3; CCL4L2; SLC9A3R1
GO:0070670 response to interleukin-4 4.16 5.80e-03 4.83e-02 5/23 XCL1; LEF1; IL2RG; GATA3; CORO1A
GO:0034109 homotypic cell-cell adhesion 4.10 2.73e-03 2.74e-02 6/28 HSPB1; ANK3; CD9; ACTG1; MYL12A; LGALS1
GO:1904019 epithelial cell apoptotic process 4.10 2.73e-03 2.74e-02 6/28 ITGA4; CFLAR; GATA3; RGCC; ZFP36L1; BCL2L1
GO:0060326 cell chemotaxis 4.03 1.24e-06 7.02e-05 16/76 FCER1G; XCL2; XCL1; LYST; LEF1; FAM65B; HSPB1; CXCR3; BIN2; HMGB1; CORO1A; CCL1; CCL3; CCL3L3; CCL4L2; TNFSF14
GO:0001906 cell killing 4.03 2.76e-05 9.19e-04 12/57 PRDX1; XCL1; LYST; GNLY; IL7R; SERPINB9; CRTAM; LAG3; IFNG; GZMB; CTSH; CORO1A
GO:0070555 response to interleukin-1 3.96 3.32e-05 9.72e-04 12/58 XCL2; XCL1; MAP3K8; NFKBIA; PYCARD; CYBA; CCL1; CCL3; CCL3L3; CCL4L2; AES; KLF2
GO:0009612 response to mechanical stimulus 3.95 1.60e-05 5.87e-04 13/63 JUN; TXNIP; BTG2; PTGER4; FAM65B; FYN; BNIP3; NFKBIA; CYBA; CNN2; TNFSF14; JUNB; JUND
GO:0043583 ear development 3.83 8.89e-04 1.30e-02 8/40 RBPJ; FAM65B; AHI1; RDH10; GATA3; MAF; SLC9A3R1; SOD1
GO:0051341 regulation of oxidoreductase activity 3.71 4.68e-03 4.23e-02 6/31 PARK7; COX17; GZMA; IFNG; CYBA; NOSIP
GO:0050866 negative regulation of cell activation 3.63 1.63e-04 3.41e-03 11/58 XCL1; ID2; TIGIT; NDFIP1; FAM65B; LST1; IL2RA; CD9; LAG3; HMGB1; SOCS1
GO:0030323 respiratory tube development 3.62 2.61e-03 2.70e-02 7/37 RBPJ; RDH10; HMGB1; CTSH; TRAF4; ADA; KLF2
GO:0060541 respiratory system development 3.53 3.06e-03 2.99e-02 7/38 RBPJ; LEF1; RDH10; HMGB1; CTSH; ADA; KLF2
GO:0002791 regulation of peptide secretion 3.47 2.86e-08 3.00e-06 25/138 TNFRSF4; CD58; CD2; GLUL; SPTBN1; DPP4; ITPR1; SELK; PTGER4; SLC25A5; RAB11FIP1; CRTAM; GATA3; SRGN; IFNG; ERP29; HMGB1; RGCC; IDH2; SOCS1; PYCARD; CCL1; CCL3; KCNN4; PIM3
GO:0022407 regulation of cell-cell adhesion 3.41 5.73e-09 1.05e-06 28/157 LCK; XCL1; DPP4; ITGA4; SELK; TIGIT; LEF1; IL7R; NDFIP1; FAM65B; HLA-DPA1; FYN; CD44; IL2RA; GATA3; MAP3K8; ANK3; CD9; LAG3; IFNG; HMGB1; RGCC; SOCS1; CORO1A; PYCARD; ADA; TNFSF14; LGALS1
GO:0032103 positive regulation of response to external stimulus 3.34 3.02e-05 9.22e-04 15/86 PARK7; FCER1G; XCL2; XCL1; PTGER4; FAM65B; HSPB1; HMGB1; NFKBIA; CYBA; CCL1; CCL3; CCL3L3; CCL4L2; TNFSF14
GO:1904950 negative regulation of establishment of protein localization 3.33 1.96e-04 3.72e-03 12/69 TNFRSF4; PARK7; PTGER4; NDFIP1; MDFIC; RAB11FIP1; SRGN; ERP29; RGCC; NDFIP2; IDH2; PIM3
GO:0042110 T cell activation 3.31 4.08e-11 1.49e-08 37/214 TNFRSF18; TNFRSF4; LCK; CD2; FCER1G; XCL1; ZFP36L2; CD8B; DPP4; SELK; TIGIT; LEF1; IL7R; PTGER4; CAMK4; NDFIP1; FAM65B; HLA-DPA1; FYN; CD3G; CRTAM; IL2RA; GATA3; MAP3K8; LAG3; IFNG; HMGB1; ZFP36L1; BATF; SOCS1; CORO1A; PYCARD; CD7; ADA; TNFSF14; LGALS1; SOD1
GO:0071241 cellular response to inorganic substance 3.28 2.26e-04 3.94e-03 12/70 JUN; ID2; CFLAR; RASGRP2; ANK3; BNIP3; HVCN1; ALOX5AP; MT2A; JUNB; JUND; SOD1
GO:0071706 tumor necrosis factor superfamily cytokine production 3.25 1.48e-03 1.77e-02 9/53 CD2; FCER1G; SELK; HSPB1; IFNG; HMGB1; PYCARD; CYBA; CCL3
GO:0007159 leukocyte cell-cell adhesion 3.23 6.73e-08 6.16e-06 26/154 LCK; XCL1; SELL; DPP4; ITGA4; SELK; TIGIT; IL7R; NDFIP1; FAM65B; HLA-DPA1; FYN; CD44; IL2RA; GATA3; MAP3K8; LAG3; IFNG; SELPLG; HMGB1; SOCS1; CORO1A; PYCARD; ADA; TNFSF14; LGALS1
GO:0045785 positive regulation of cell adhesion 3.17 1.81e-07 1.21e-05 25/151 TNFRSF18; LCK; S100A10; XCL1; DPP4; ITGA4; SELK; IL7R; HLA-DPA1; FYN; CDK6; NINJ1; CD44; IL2RA; GATA3; MAP3K8; ANK3; IFNG; HMGB1; SOCS1; CORO1A; PYCARD; ADA; TNFSF14; LGALS1
GO:0034341 response to interferon-gamma 3.15 1.07e-04 2.53e-03 14/85 CD58; XCL2; XCL1; HLA-DQA1; HLA-DPA1; CD44; IFNG; SOCS1; MT2A; CCL1; CCL3; CCL3L3; CCL4L2; ACTG1
GO:0002285 lymphocyte activation involved in immune response 3.15 3.39e-04 5.55e-03 12/73 FCER1G; LEF1; PTGER4; NDFIP1; ITM2A; GATA3; IFNG; HMGB1; BATF; CORO1A; ADA; LGALS1
GO:0045444 fat cell differentiation 3.08 2.20e-03 2.40e-02 9/56 ID2; ZFP36L2; PSMB8; TMEM120A; GATA3; BNIP3; ZFP36L1; SOCS1; ATF5
GO:0050920 regulation of chemotaxis 3.08 2.20e-03 2.40e-02 9/56 XCL2; XCL1; FAM65B; HSPB1; HMGB1; CCL1; CCL3; CCL4L2; TNFSF14
GO:0002521 leukocyte differentiation 3.03 9.25e-09 1.36e-06 32/202 TNFRSF18; LCK; JUN; CD2; FCER1G; ID2; ZFP36L2; ITGA4; CMTM7; RBPJ; LEF1; IL7R; PTGER4; CAMK4; CSF2; NDFIP1; CDK6; ITM2A; CD3G; IL2RA; GATA3; IFNG; HMGB1; ZFP36L1; BATF; SOCS1; EVI2B; CCL3; ADA; JUNB; LGALS1; SOD1
GO:0097191 extrinsic apoptotic signaling pathway 3.02 1.00e-04 2.44e-03 15/95 TNFRSF4; PARK7; LMNA; CFLAR; SIAH2; TNFSF10; CSF2; FYN; NGFRAP1; TRAF1; IFNG; PYCARD; PMAIP1; BCL2L1; CD70
GO:0002449 lymphocyte mediated immunity 3.00 6.36e-05 1.61e-03 16/102 PRDX1; FCER1G; XCL1; LYST; IL7R; NDFIP1; SERPINB9; CRTAM; GATA3; LAG3; KLRD1; HMGB1; GZMB; BATF; CTSH; CORO1A
GO:0051047 positive regulation of secretion 2.95 2.89e-05 9.22e-04 18/117 TNFRSF4; CD58; CD2; FCER1G; GLUL; SPTBN1; SELK; PTGER4; CRTAM; GATA3; IFNG; HMGB1; RGCC; PYCARD; CYBA; CCL1; CCL3; KCNN4
GO:0002694 regulation of leukocyte activation 2.93 2.17e-08 2.65e-06 32/209 TNFRSF18; TNFRSF4; LCK; CD2; FCER1G; XCL1; ID2; ZFP36L2; DPP4; SELK; TIGIT; IL7R; CAMK4; NDFIP1; FAM65B; LST1; HLA-DPA1; FYN; IL2RA; GATA3; MAP3K8; LAG3; IFNG; HMGB1; ZFP36L1; SOCS1; CORO1A; PYCARD; ADA; TNFSF14; LGALS1; SOD1
GO:0001818 negative regulation of cytokine production 2.93 1.44e-04 3.14e-03 15/98 TNFRSF4; XCL1; REL; TIGIT; LEF1; PTGER4; NDFIP1; GATA3; SRGN; LAG3; IFNG; HMGB1; RGCC; PYCARD; KLF2
GO:0001819 positive regulation of cytokine production 2.92 9.20e-07 5.62e-05 25/164 PARK7; CD58; CD2; FCER1G; XCL1; SPTBN1; SELK; TIGIT; PTGER4; CSF2; LTB; HLA-DPA1; HSPB1; BIRC3; CRTAM; GATA3; NFKB2; IFNG; HMGB1; RGCC; PYCARD; CYBA; CCL1; CCL3; SOD1
GO:0048872 homeostasis of number of cells 2.87 4.11e-05 1.11e-03 18/120 TNFRSF4; PRDX1; FCER1G; ID2; IL7R; SFXN1; CDK6; IL2RA; GATA3; HMGB1; ZFP36L1; KLF13; CORO1A; PMAIP1; ADA; TNFSF14; KLF2; SOD1
GO:0050727 regulation of inflammatory response 2.84 2.03e-04 3.72e-03 15/101 PARK7; FCER1G; XCL1; PTGER4; NDFIP1; BIRC3; IL2RA; GATA3; NFKBIA; PYCARD; CCL1; CCL3; CCL3L3; ADA; GPX4
GO:0050867 positive regulation of cell activation 2.83 1.16e-05 4.73e-04 21/142 TNFRSF4; LCK; CD2; FCER1G; XCL1; DPP4; SELK; IL7R; HLA-DPA1; FYN; IL2RA; GATA3; MAP3K8; IFNG; HMGB1; SOCS1; CORO1A; PYCARD; ADA; TNFSF14; LGALS1
GO:0048568 embryonic organ development 2.82 3.59e-04 5.72e-03 14/95 ID2; RBPJ; LEF1; CSF2; FAM65B; AHI1; RDH10; MICAL2; GATA3; ZFP36L1; SLC9A3R1; ADA; JUNB; SOD1
GO:0042063 gliogenesis 2.81 1.59e-03 1.88e-02 11/75 PHGDH; ID2; BIN1; LEF1; CDK6; BNIP3; CD9; SYNE2; IDH2; CCL3; SOD1
GO:0052547 regulation of peptidase activity 2.80 5.16e-06 2.36e-04 23/157 PARK7; LCK; BIN1; CFLAR; SIAH2; TNFSF10; SPINK2; LEF1; TNFAIP8; SERPINB9; PSMB8; FYN; NGFRAP1; CD44; BIRC3; SORL1; HMGB1; PSME1; CTSH; PYCARD; HERPUD1; PMAIP1; TNFSF14
GO:1903706 regulation of hemopoiesis 2.80 2.04e-06 1.07e-04 25/171 TNFRSF18; JUN; CD2; H3F3A; ID2; ZFP36L2; LEF1; IL7R; CAMK4; CSF2; NDFIP1; CDK6; IL2RA; GATA3; IFNG; HMGB1; NFKBIA; ZFP36L1; KLF13; SOCS1; EVI2B; CCL3; ADA; LGALS1; SOD1
GO:0072507 divalent inorganic cation homeostasis 2.80 3.63e-05 1.02e-03 19/130 LCK; XCL1; ITPR1; SELK; CCDC109B; PTGER4; FYN; CXCR3; ANK3; BNIP3; HMGB1; CORO1A; MT2A; HERPUD1; CYBA; CCL1; CCL3; S1PR4; PTGIR
GO:0051271 negative regulation of cellular component movement 2.77 1.77e-03 2.05e-02 11/76 BIN1; PTGER4; FAM65B; GATA3; CD9; ARHGDIB; HMGB1; RGCC; IDH2; SLC9A3R1; ADA
GO:0070661 leukocyte proliferation 2.76 1.79e-04 3.54e-03 16/111 TNFRSF4; XCL1; SELK; LEF1; IL7R; NDFIP1; LST1; HLA-DPA1; FYN; CRTAM; IL2RA; HMGB1; CORO1A; PYCARD; ADA; TNFSF14
GO:2000147 positive regulation of cell motility 2.73 1.26e-05 4.87e-04 22/154 TNFRSF18; JUN; XCL2; XCL1; ITGA4; SELK; LEF1; FAM65B; HSPB1; FAM89B; GATA3; IFNG; HMGB1; SYNE2; CTSH; CORO1A; PYCARD; MAP2K3; CCL1; CCL3; CCL4L2; TNFSF14
GO:0007162 negative regulation of cell adhesion 2.73 1.25e-03 1.63e-02 12/84 XCL1; TIGIT; NDFIP1; FAM65B; IL2RA; CD9; LAG3; ARHGDIB; HMGB1; RGCC; SOCS1; LGALS1
GO:0007389 pattern specification process 2.73 4.99e-03 4.36e-02 9/63 BTG2; ZEB2; BHLHE40; RBPJ; LEF1; AHI1; MICAL2; EED; KIF3B
GO:0035821 modification of morphology or physiology of other organism 2.73 4.99e-03 4.36e-02 9/63 JUN; GNLY; LEF1; SERPINB9; IFNG; CCL3; CCL4L2; BCL2L1; RRP1B
GO:0048511 rhythmic process 2.70 1.39e-03 1.75e-02 12/85 JUN; ID2; BHLHE40; SIAH2; CSF2; NAMPT; PRKCDBP; CREM; NFKB2; ADA; JUND; ATF5
GO:0002683 negative regulation of immune system process 2.65 2.12e-05 7.39e-04 22/159 TNFRSF4; FCER1G; XCL1; ID2; TIGIT; IL7R; PTGER4; NDFIP1; SERPINB9; FAM65B; LST1; CDK6; IL2RA; LAG3; HMGB1; NFKBIA; ZFP36L1; KLF13; SOCS1; CCL3; SAMHD1; ADA
GO:0003013 circulatory system process 2.61 1.88e-03 2.12e-02 12/88 XCL2; ID2; BIN1; ITPR1; HRH2; FYN; NAMPT; CYBA; MAP2K3; SCPEP1; ADA; SOD1
GO:0010038 response to metal ion 2.59 5.79e-04 9.03e-03 15/111 PARK7; JUN; TXNIP; ID2; AQP3; RASGRP2; ANK3; BNIP3; HVCN1; ALOX5AP; MT2A; ATP5D; JUNB; JUND; SOD1
GO:0019932 second-messenger-mediated signaling 2.55 2.28e-03 2.43e-02 12/90 RAMP1; ITPR1; SELK; PTGER4; CXCR3; CCL3; CCL4L2; SLC9A3R1; ADA; S1PR4; ADGRE5; PTGIR
GO:0090130 tissue migration 2.54 3.62e-03 3.42e-02 11/83 JUN; GLUL; ZEB2; DPP4; HSPB1; GATA3; IFNG; HMGB1; RGCC; CTSH; MAP2K3
GO:0001667 ameboidal-type cell migration 2.50 1.22e-03 1.62e-02 14/107 JUN; GLUL; ZEB2; DPP4; ITGA4; HSPB1; GATA3; ARHGDIB; IFNG; HMGB1; RGCC; CTSH; CENPV; MAP2K3
GO:0030099 myeloid cell differentiation 2.48 6.06e-05 1.59e-03 22/170 JUN; FCER1G; H3F3A; ID2; RBPJ; LEF1; CAMK4; CSF2; NDFIP1; SFXN1; CDK6; GATA3; IFNG; HMGB1; NFKBIA; ZFP36L1; BATF; KLF13; EVI2B; CCL3; JUNB; KLF2
GO:0002250 adaptive immune response 2.47 1.98e-04 3.72e-03 19/147 FCER1G; XCL1; CD8B; LEF1; IL7R; CAMK4; NDFIP1; FYN; CD3G; CRTAM; GATA3; NFKB2; IFNG; HMGB1; BATF; CTSH; PYCARD; CD7; ADA
GO:0042113 B cell activation 2.46 1.46e-03 1.77e-02 14/109 TNFRSF4; ID2; ZFP36L2; ITGA4; CMTM7; RBPJ; LEF1; IL7R; NDFIP1; ITM2A; ZFP36L1; BATF; ADA; LGALS1
GO:0009615 response to virus 2.46 2.17e-04 3.87e-03 19/148 XCL1; LYST; SELK; SERINC5; HMGA1; HSPB1; CDK6; BIRC3; IL2RA; GATA3; BNIP3; IFNG; ISG20; PYCARD; CCL4L2; PMAIP1; BCL2L1; SAMHD1; RRP1B
GO:0050673 epithelial cell proliferation 2.44 3.31e-03 3.19e-02 12/94 JUN; GLUL; ID2; ITGA4; CFLAR; CDK6; MTSS1; GATA3; HMGB1; RGCC; ZFP36L1; CYBA
GO:0051051 negative regulation of transport 2.44 2.37e-04 4.04e-03 19/149 TNFRSF4; PARK7; BIN1; PTGER4; NDFIP1; MDFIC; SLC25A5; RAB11FIP1; ANK3; SRGN; ERP29; HMGB1; RGCC; NDFIP2; IDH2; CORO1A; SLC9A3R1; ADA; PIM3
GO:0001525 angiogenesis 2.39 1.32e-03 1.70e-02 15/120 JUN; SH2D2A; GLUL; RAMP1; RBPJ; LEF1; HSPB1; SRPK2; CXCR3; HMGB1; RGCC; WARS; PKM; CTSH; KLF2
GO:0051235 maintenance of location 2.33 2.44e-03 2.56e-02 14/115 PARK7; LCK; XCL1; TMSB10; ITPR1; SORL1; ANK3; SRGN; NFKBIA; SYNE2; CORO1A; CYBA; CCL3; FTL
GO:2001233 regulation of apoptotic signaling pathway 2.32 1.18e-04 2.69e-03 23/190 TNFRSF4; PARK7; LCK; LMNA; CFLAR; SIAH2; TNFSF10; CSF2; FYN; HSPB1; SLC25A5; TRAF1; CD44; BNIP3; ERP29; GZMB; CTSH; PYCARD; HERPUD1; SLC9A3R1; PMAIP1; BCL2L1; SOD1
GO:0072511 divalent inorganic cation transport 2.29 2.88e-03 2.85e-02 14/117 LCK; XCL1; BIN1; RAMP1; ITPR1; SELK; CCDC109B; FYN; SARAF; CORO1A; CYBA; CCL3; CCL4L2; KCNN4
GO:0045861 negative regulation of proteolysis 2.23 3.64e-03 3.42e-02 14/120 PARK7; BIN1; CFLAR; SIAH2; SPINK2; LEF1; TNFAIP8; SERPINB9; NGFRAP1; CD44; BIRC3; SORL1; HERPUD1; TNFSF14
GO:0043087 regulation of GTPase activity 2.22 8.07e-04 1.23e-02 19/164 JUN; S100A10; XCL2; XCL1; RGS1; SNX9; TAGAP; RASGRP2; RGS10; ARHGDIB; PYCARD; ACAP1; CCL1; CCL3; CCL3L3; CCL4L2; STMN3; SOD1; RRP1B
GO:1904951 positive regulation of establishment of protein localization 2.21 3.41e-04 5.55e-03 22/191 TNFRSF4; CD58; CD2; GLUL; SPTBN1; CAMK1; SELK; PTGER4; FYN; SORL1; CRTAM; GATA3; ANK3; IFNG; HMGB1; RGCC; GZMB; PYCARD; CCL1; CCL3; PMAIP1; KCNN4
GO:0051098 regulation of binding 2.20 8.69e-04 1.30e-02 19/165 PARK7; EPB41; JUN; S100A10; PYHIN1; ID2; ITGA4; CAMK1; LEF1; GZMA; FAM65B; SORL1; GATA3; IFNG; HMGB1; NFKBIA; HERPUD1; TRAF4; AES
GO:0050878 regulation of body fluid levels 2.14 3.95e-03 3.62e-02 15/134 CAPZB; LCK; FCER1G; H3F3A; ITPR1; FYN; HSPB1; AQP3; GATA3; CD9; CYBA; ACTG1; MYL12A; ADA; KCNN4
GO:0098542 defense response to other organism 2.14 2.22e-03 2.40e-02 17/152 FCER1G; LYST; GNLY; SELK; RBPJ; SERINC5; BIRC3; IL2RA; BNIP3; IFNG; BATF; ISG20; PYCARD; COTL1; CYBA; PMAIP1; SAMHD1
GO:0071496 cellular response to external stimulus 2.13 5.66e-03 4.77e-02 14/126 JUN; GLUL; PTGER4; FAM65B; FYN; NAMPT; AQP3; BNIP3; CYBA; PMAIP1; CNN2; AES; TNFSF14; SOD1
GO:0070482 response to oxygen levels 2.07 5.58e-03 4.76e-02 15/139 LMNA; DPP4; CFLAR; ITPR1; RBPJ; NAMPT; AQP3; BNIP3; RGCC; ZFP36L1; PKM; CYBA; PMAIP1; ADA; MT-ND5
GO:0051346 negative regulation of hydrolase activity 2.03 5.10e-03 4.40e-02 16/151 PARK7; BIN1; CFLAR; SIAH2; SPINK2; LEF1; GZMA; TNFAIP8; SERPINB9; NGFRAP1; CD44; BIRC3; SORL1; HERPUD1; TNFSF14; RRP1B
Factor 8 : 38 significant GO terms
GeneSet description enrichRatio pValue FDR GeneRatio geneSymbols
GO:0070972 protein localization to endoplasmic reticulum 11.50 0.00e+00 0.00e+00 79/121 RPL22; RPL11; RPS8; RPL5; RPS27; RPS7; RPS27A; RPL31; RPL37A; RPL32; RPL15; RPSA; RPL14; RPL29; RPL24; RPL35A; RPL9; RPL34; RPS3A; RPL37; RPS23; RPS14; RPS18; RPS10; RPL10A; RPS12; RPS4X; RPL36A; RPL39; RPL10; RPS20; RPL7; RPL30; RPL8; RPS6; SEC61B; RPL35; RPL12; RPL7A; RPLP2; RPL27A; RPS13; RPS3; RPS25; RPS24; RPL41; RPL6; RPLP0; RPL21; RPS29; SRP14; RPL4; RPLP1; RPS17; RPS2; RPS15A; RPL13; RPL26; RPL23A; RPL23; RPL19; RPL27; RPL38; RPL17; RPS21; RPS15; RPL36; RPS28; RPL18A; UBA52; RPS16; RPS19; RPL18; RPL13A; RPS11; RPS9; RPL28; RPS5; RPL3
GO:0006413 translational initiation 9.14 0.00e+00 0.00e+00 83/160 RPL22; RPL11; RPS8; RPL5; RPS27; RPS7; RPS27A; RPL31; RPL37A; RPL32; RPL15; RPSA; RPL14; RPL29; RPL24; RPL35A; RPL9; RPL34; RPS3A; RPL37; RPS23; RPS14; NPM1; RPS18; RPS10; RPL10A; RPS12; RPS4X; RPL36A; RPL39; RPL10; RPS20; RPL7; RPL30; PABPC1; EIF3E; RPL8; RPS6; RPL35; RPL12; RPL7A; RPLP2; RPL27A; RPS13; EIF3M; PPP1CA; RPS3; RPS25; RPS24; RPL41; RPL6; RPLP0; RPL21; RPS29; RPL4; RPLP1; RPS17; RPS2; RPS15A; RPL13; RPL26; RPL23A; RPL23; RPL19; RPL27; RPL38; RPL17; RPS21; RPS15; RPL36; RPS28; RPL18A; UBA52; RPS16; RPS19; RPL18; RPL13A; RPS11; RPS9; RPL28; RPS5; RPL3; ATF4
GO:0002181 cytoplasmic translation 7.85 0.00e+00 0.00e+00 33/74 RPL11; RPL31; RPL32; RPL15; TMA7; RPL29; RPL24; RPL35A; RPL9; RPS23; RPL10A; RPL36A; RPL39; RPL30; EIF3E; RPL8; EIF3M; RPL41; RPL6; RPLP0; RPS29; RPLP1; RPL26; RPL19; RPL38; RPL17; RPS21; EEF2; RPL36; RPS28; RPL18A; RPL18; RPL13A
GO:0090150 establishment of protein localization to membrane 7.34 0.00e+00 0.00e+00 85/204 RPL22; RPL11; RPS8; RPL5; RPS27; RPS7; RPS27A; RPL31; RPL37A; RPL32; RPL15; RPSA; RPL14; RPL29; RPL24; RPL35A; RPL9; RPL34; RPS3A; RPL37; RPS23; RPS14; GNB2L1; RPS18; RPS10; RPL10A; RPS12; RPS4X; RPL36A; RPL39; RPL10; RPS20; RPL7; RPL30; YWHAZ; RPL8; RPS6; SEC61B; RPL35; RPL12; RPL7A; RPLP2; RPL27A; RPS13; RPS3; RPS25; RPS24; RPL41; RPL6; RPLP0; RPL21; RPS29; CALM1; SRP14; RPL4; RPLP1; RPS17; RPS2; RPS15A; RPL13; RPL26; RPL23A; RPL23; RPL19; RPL27; RPL38; RPL17; PMAIP1; YWHAB; RPS21; RPS15; RPL36; RPS28; RPL18A; UBA52; RPS16; RPS19; RPL18; RPL13A; RPS11; RPS9; RPL28; RPS5; RPL3; ITGB2
GO:0006605 protein targeting 6.01 0.00e+00 0.00e+00 87/255 RPL22; RPL11; RPS8; RPL5; RPS27; RPS7; RPS27A; RPL31; HSPD1; RPL37A; RPL32; RPL15; RPSA; RPL14; RPL29; RPL24; RPL35A; RPL9; RPL34; RPS3A; RPL37; RPS23; RPS14; RPS18; RPS10; RPL10A; RPS12; SLC25A6; RPS4X; RPL36A; RPL39; RPL10; RPS20; RPL7; RPL30; YWHAZ; RPL8; RPS6; SEC61B; RPL35; RPL12; RPL7A; RPLP2; RPL27A; RPS13; RPS3; RPS25; HSPA8; RPS24; RPL41; RPL6; RPLP0; RPL21; RPS29; SRP14; RPL4; RPLP1; RPS17; RPS2; RPS15A; RPL13; RPL26; RPL23A; RPL23; RPL19; RPL27; RPL38; RPL17; YWHAB; RPS21; RPS15; RPL36; RPS28; UBL5; RPL18A; UBA52; RPS16; RPS19; RPL18; RPL13A; RPS11; RPS9; RPL28; RPS5; RAC2; RPL3; ITGB2
GO:0006401 RNA catabolic process 5.99 0.00e+00 0.00e+00 86/253 RPL22; RPL11; RPS8; RPL5; RPS27; RPS7; RPS27A; RPL31; RPL37A; RPL32; RPL15; RPSA; RPL14; RPL29; RPL24; RPL35A; RPL9; RPL34; RPS3A; RPL37; RPS23; RPS14; NPM1; RPS18; RPS10; RPL10A; RPS12; RPS4X; RPL36A; RPL39; RPL10; RPS20; RPL7; RPL30; PABPC1; YWHAZ; EIF3E; RPL8; RPS6; RPL35; RPL12; RPL7A; RPLP2; RPL27A; RPS13; RPS3; RPS25; HSPA8; VIM; RPS24; RPL41; RPL6; RPLP0; RPL21; RPS29; RPL4; RPLP1; RPS17; RPS2; CARHSP1; RPS15A; RPL13; RPL26; RPL23A; RPL23; RPL19; RPL27; RPL38; RPL17; YWHAB; RPS21; RPS15; RPL36; RPS28; RPL18A; LSM4; UBA52; RPS16; RPS19; RPL18; RPL13A; RPS11; RPS9; RPL28; RPS5; RPL3
GO:0048013 ephrin receptor signaling pathway 5.68 4.56e-06 1.86e-04 10/31 CDC42; ARPC5; ACTR3; ARPC2; ARPC4; ACTB; ARPC1B; ARPC3; ACTG1; AP2S1
GO:0034109 homotypic cell-cell adhesion 5.66 1.44e-05 5.54e-04 9/28 CLIC1; ACTB; FLNA; TLN1; PTPN6; ACTG1; MYL12A; MYH9; LGALS1
GO:0030048 actin filament-based movement 4.23 2.25e-03 4.46e-02 6/25 TPM3; FLNA; VIM; MYL6; TPM4; MYH9
GO:0070671 response to interleukin-12 4.03 6.01e-04 1.33e-02 8/35 CDC42; HNRNPA2B1; PPIA; CFL1; RPLP0; LCP1; PSME2; ANXA2
GO:0032970 regulation of actin filament-based process 4.00 2.55e-10 2.66e-08 27/119 CAPZB; CDC42; STMN1; S100A10; ARPC5; TMSB10; CAPG; ACTR3; ARPC2; ARPC4; WDR1; PTGER4; ABRACL; FSCN1; ARPC1B; TMSB4X; FLNA; CFL1; ARHGDIB; ARPC3; CORO1A; PYCARD; PFN1; ARHGDIA; GMFG; MYH9; SH3BP1
GO:0007015 actin filament organization 3.85 2.90e-10 2.66e-08 28/128 CAPZB; CDC42; STMN1; CAP1; S100A10; TPM3; ARPC5; TMSB10; CAPG; ACTR3; ARPC2; ARPC4; WDR1; PTGER4; FSCN1; ARPC1B; TMSB4X; FLNA; CFL1; ARPC3; LCP1; CORO1A; PYCARD; PFN1; TPM4; GMFG; RAC2; SH3BP1
GO:1902600 proton transmembrane transport 3.66 4.51e-06 1.86e-04 16/77 COX5B; COX17; COX7A2; NDUFA4; ATP5J2; TMSB4X; COX7B; COX6C; COX8A; ATP5L; COX6A1; ATP5E; COX6B1; ATP5J; MT-CO3; MT-CYB
GO:0006909 phagocytosis 3.60 1.44e-06 8.77e-05 18/88 CDC42; ARPC5; ACTR3; ARPC2; ARPC4; GNB2L1; HSP90AB1; ACTB; ARPC1B; ARPC3; HMGB1; CORO1A; PYCARD; CYBA; ACTG1; MYH9; SH3BP1; ITGB2
GO:1902903 regulation of supramolecular fiber organization 3.49 4.46e-08 3.48e-06 24/121 CAPZB; CDC42; STMN1; S100A10; ARPC5; TMSB10; CAPG; ACTR3; ARPC2; ARPC4; WDR1; PTGER4; ARPC1B; TMSB4X; FLNA; CFL1; RPS3; HSPA8; ARPC3; CORO1A; PYCARD; PFN1; GMFG; SH3BP1
GO:0034341 response to interferon-gamma 3.11 6.93e-05 2.31e-03 15/85 ACTR3; HLA-DRA; HLA-DRB5; HLA-DRB1; HLA-DQA1; HLA-DQB1; HLA-DPA1; HLA-DPB1; HSP90AB1; VIM; B2M; SOCS1; MT2A; ACTG1; RPL13A
GO:0019882 antigen processing and presentation 2.62 5.02e-04 1.19e-02 15/101 CAPZB; VAMP8; CD74; HLA-DRA; HLA-DRB5; HLA-DRB1; HLA-DQA1; HLA-DQB1; PSMB8; HLA-DPA1; HLA-DPB1; DCTN3; B2M; PYCARD; AP2S1
GO:0071826 ribonucleoprotein complex subunit organization 2.61 2.00e-06 1.03e-04 28/189 RPL11; RPL5; RPS27; SNRPG; RPSA; RPL24; RPS23; RPS14; NPM1; RPS10; HSP90AB1; RPL10; EIF3E; RPL12; EIF3M; RPL6; RPLP0; RSL24D1; RPL23A; RPL38; RPS15; RPS28; LSM4; RPS19; GLTSCR2; RPL13A; RPS5; RPL3
GO:0002764 immune response-regulating signaling pathway 2.58 7.30e-07 4.86e-05 31/212 CDC42; LCK; ARPC5; RPS27A; ACTR3; HSPD1; ARPC2; ARPC4; FLOT1; HLA-DRA; HLA-DRB5; HLA-DRB1; HLA-DQA1; HLA-DQB1; HLA-DPA1; HLA-DPB1; HSP90AB1; ACTB; ARPC1B; RPS3; CD3D; PTPN6; ARPC3; HMGB1; CALM1; CYBA; ACTG1; ADA; UBA52; GLTSCR2; ITGB2
GO:0016072 rRNA metabolic process 2.57 4.13e-06 1.86e-04 27/185 RPL11; RPS8; RPL5; RPS27; RPS7; NCL; RPSA; RPL14; RPL35A; RPS14; RPL10A; RPL7; RPS6; RPL35; RPL7A; RPS24; RPS17; RPS2; RPL26; RPL27; RPS21; RPS15; RPS28; RPS16; RPS19; GLTSCR2; RPS9
GO:0051493 regulation of cytoskeleton organization 2.55 2.04e-06 1.03e-04 29/200 CAPZB; CDC42; STMN1; S100A10; ARPC5; TMSB10; CAPG; ACTR3; ARPC2; ARPC4; WDR1; PTGER4; NPM1; FSCN1; ARPC1B; TMSB4X; FLNA; CFL1; CDK2AP2; RPS3; ARHGDIB; ARPC3; CORO1A; PYCARD; PFN1; ARHGDIA; GMFG; CHMP2A; SH3BP1
GO:0051258 protein polymerization 2.52 3.44e-04 9.01e-03 17/119 CAPZB; STMN1; ARPC5; TMSB10; CAPG; ACTR3; ARPC2; ARPC4; ARPC1B; TMSB4X; RPS3; ARPC3; CORO1A; PYCARD; PFN1; GMFG; CHMP2A
GO:0050878 regulation of body fluid levels 2.50 1.71e-04 4.83e-03 19/134 CAPZB; CDC42; STMN1; LCK; H3F3A; VAMP8; GNAI2; CLIC1; ACTB; FLNA; YWHAZ; TLN1; PTPN6; ANXA2; CYBA; ACTG1; MYL12A; ADA; MYH9
GO:0050817 coagulation 2.49 1.26e-03 2.64e-02 14/99 CAPZB; CDC42; LCK; H3F3A; CLIC1; ACTB; FLNA; YWHAZ; TLN1; PTPN6; ANXA2; ACTG1; MYL12A; MYH9
GO:0090066 regulation of anatomical structure size 2.48 1.27e-04 3.88e-03 20/142 CAPZB; ARPC5; TMSB10; CAPG; ACTR3; ARPC2; ARPC4; WDR1; HSP90AB1; ARPC1B; TMSB4X; CFL1; PPP1CA; ARPC3; CORO1A; PYCARD; PFN1; SNF8; GMFG; SH3BP1
GO:0050900 leukocyte migration 2.43 5.11e-04 1.19e-02 17/123 LCK; SELL; WDR1; PTGER4; CD74; GPSM3; PPIA; DOK2; PTPN6; HMGB1; CORO1A; PYCARD; ADA; RPS19; MYH9; RAC2; ITGB2
GO:0070661 leukocyte proliferation 2.38 1.37e-03 2.79e-02 15/111 HSPD1; IMPDH2; CD74; HLA-DPA1; HLA-DPB1; CCND3; RPS6; GSTP1; RPS3; PTPN6; HMGB1; CORO1A; PYCARD; ADA; RAC2
GO:0006091 generation of precursor metabolites and energy 2.37 2.11e-06 1.03e-04 33/245 DHRS3; SH3BGRL3; COX5B; COX17; UQCRQ; NDUFA2; PRELID1; COX7A2; NDUFA4; ATP5J2; NDUFB2; COX7B; NDUFA1; COX6C; COX8A; PPP1CA; ATP5L; NDUFB8; BNIP3; BLOC1S1; NDUFA12; COX6A1; HMGB1; PKM; IDH2; CYBA; ATP5E; NDUFB7; COX6B1; GLTSCR2; ATP5J; MT-CO3; MT-CYB
GO:0022613 ribonucleoprotein complex biogenesis 2.32 4.75e-08 3.48e-06 45/342 RPL11; RPS8; RPL5; RPS27; RPS7; SNRPG; RPSA; RPL14; RPL24; RPL35A; RPS23; RPS14; NPM1; RPS10; RPL10A; HSP90AB1; RPL10; RPL7; EIF3E; RPS6; RPL35; RPL12; RPL7A; EIF3M; RPS24; RPL6; RPLP0; RSL24D1; RPS17; RPS2; RPL26; RPL23A; RPL27; RPL38; RPS21; RPS15; RPS28; LSM4; RPS16; RPS19; GLTSCR2; RPL13A; RPS9; RPS5; RPL3
GO:0043254 regulation of protein complex assembly 2.30 3.41e-05 1.25e-03 27/207 CAPZB; CDC42; STMN1; ARPC5; H3F3A; TMSB10; CAPG; ACTR3; ARPC2; ARPC4; PTGER4; GNB2L1; FSCN1; ARPC1B; TMSB4X; RPS3; HSPA8; ARPC3; HMGB1; LCP1; CORO1A; PYCARD; PFN1; PMAIP1; GMFG; GLTSCR2; RPL13A
GO:0042110 T cell activation 2.22 6.18e-05 2.16e-03 27/214 CDC42; LCK; CD8B; HSPD1; PTGER4; CD74; PRELID1; HLA-DPA1; HLA-DPB1; CCND3; RPS6; RPS3; CD3D; CD27; PTPN6; HMGB1; LCP1; B2M; SOCS1; CORO1A; PYCARD; CD7; FKBP1A; ADA; MYH9; RAC2; LGALS1
GO:0045785 positive regulation of cell adhesion 2.22 8.04e-04 1.73e-02 19/151 CDC42; LCK; S100A10; HSPD1; ARPC2; CD74; FLOT1; HLA-DPA1; HLA-DPB1; FLNA; RPS3; CD27; PTPN6; HMGB1; SOCS1; CORO1A; PYCARD; ADA; LGALS1
GO:0009141 nucleoside triphosphate metabolic process 2.21 1.71e-04 4.83e-03 24/191 GUK1; COX5B; IMPDH2; UQCRQ; NDUFA2; COX7A2; NUDT1; NDUFA4; ATP5J2; NDUFB2; TMSB4X; NDUFA1; ATP5L; HSPA8; NDUFB8; NDUFA12; COX6A1; PKM; ADA; ATP5E; NDUFB7; ATP5J; MT-CO3; MT-CYB
GO:0072507 divalent inorganic cation homeostasis 2.17 2.59e-03 4.75e-02 16/130 CD52; LCK; PTGER4; BNIP3; PTPN6; HMGB1; CALM1; ANXA2; CORO1A; MT2A; MT1E; HERPUD1; CYBA; FKBP1A; ATF4; SMDT1
GO:0050867 positive regulation of cell activation 2.11 2.59e-03 4.75e-02 17/142 CDC42; LCK; VAMP8; HSPD1; CD74; HLA-DPA1; HLA-DPB1; RPS3; CD27; PTPN6; HMGB1; SOCS1; CORO1A; PYCARD; ADA; LGALS1; ITGB2
GO:0009123 nucleoside monophosphate metabolic process 2.10 3.74e-04 9.44e-03 24/201 GUK1; COX5B; IMPDH2; PAICS; UQCRQ; NDUFA2; COX7A2; NDUFA4; ATP5J2; NDUFB2; TMSB4X; NDUFA1; ATP5L; HSPA8; NDUFB8; NDUFA12; COX6A1; PKM; ADA; ATP5E; NDUFB7; ATP5J; MT-CO3; MT-CYB
GO:0002446 neutrophil mediated immunity 2.06 7.61e-05 2.43e-03 31/265 CAP1; S100A11; SELL; ARPC5; VAMP8; IMPDH2; WDR1; HSP90AB1; EEF1A1; HEBP2; PPIA; FABP5; OSTF1; FTH1; GSTP1; HSPA8; PTPN6; HMGB1; SRP14; B2M; ANXA2; PKM; PYCARD; COTL1; CYBA; TRAPPC1; EEF2; GMFG; CCT8; CSTB; ITGB2
GO:0007159 leukocyte cell-cell adhesion 2.06 2.56e-03 4.75e-02 18/154 CDC42; LCK; SELL; HSPD1; CD74; HLA-DPA1; HLA-DPB1; RPS3; CD27; PTPN6; HMGB1; SOCS1; CORO1A; PYCARD; ADA; RAC2; LGALS1; ITGB2
Factor 9 : 54 significant GO terms
GeneSet description enrichRatio pValue FDR GeneRatio geneSymbols
GO:0050918 positive chemotaxis 14.50 1.09e-04 4.22e-03 4/11 LGALS3; CORO1A; CCL5; CCL3
GO:0042092 type 2 immune response 11.90 1.63e-03 2.66e-02 3/10 XCL1; CD74; GATA3
GO:0070670 response to interleukin-4 10.40 1.59e-05 8.33e-04 6/23 XCL1; LEF1; TCF7; GATA3; TUBA1B; CORO1A
GO:0034109 homotypic cell-cell adhesion 9.95 4.09e-06 3.21e-04 7/28 CLIC1; ACTB; ANK3; CD9; CCL5; ACTG1; MYL12A
GO:0032633 interleukin-4 production 9.95 5.48e-04 1.20e-02 4/16 LEF1; HAVCR2; HLA-E; GATA3
GO:0031579 membrane raft organization 9.95 2.89e-03 4.15e-02 3/12 CD2; S100A10; ANXA2
GO:0044091 membrane biogenesis 9.95 2.89e-03 4.15e-02 3/12 S100A10; ANK3; ANXA2
GO:0034341 response to interferon-gamma 9.36 7.99e-15 5.86e-12 20/85 GBP2; XCL1; HLA-E; HLA-DRA; HLA-DRB5; HLA-DRB1; HLA-DQA1; HLA-DQB1; HLA-DPA1; HLA-DPB1; VIM; GAPDH; SOCS1; MT2A; CCL5; CCL3; CCL3L3; ACTG1; BST2; RPL13A
GO:1990868 response to chemokine 7.96 1.35e-03 2.30e-02 4/20 XCL1; CCL5; CCL3; CCL3L3
GO:0030101 natural killer cell activation 6.86 6.77e-04 1.42e-02 5/29 PRDX1; CD2; HAVCR2; HLA-E; CORO1A
GO:0032609 interferon-gamma production 6.82 2.00e-04 6.65e-03 6/35 CD2; XCL1; HAVCR2; HLA-DPA1; HLA-DPB1; GATA3
GO:0060326 cell chemotaxis 6.81 3.43e-08 8.37e-06 13/76 XCL1; LYST; LEF1; ITGA1; CD74; TMSB4X; JAML; LGALS3; CORO1A; CKLF; CCL5; CCL3; CCL3L3
GO:0006959 humoral immune response 6.63 2.35e-04 7.02e-03 6/36 HLA-E; HLA-DQB1; SH2D1A; GATA3; GAPDH; BST2
GO:0051702 interaction with symbiont 6.28 3.19e-04 9.00e-03 6/38 LEF1; GAPDH; CALM1; ANXA2; CCL5; CCL3
GO:0043270 positive regulation of ion transport 6.18 1.13e-05 6.38e-04 9/58 XCL1; TMSB4X; ANK3; LGALS3; CALM1; ANXA2; CCL5; CCL3; TSPO
GO:0002576 platelet degranulation 5.82 4.89e-04 1.12e-02 6/41 TAGLN2; TUBA4A; TMSB4X; CTSW; CD9; CALM1
GO:0001906 cell killing 5.59 7.49e-05 3.23e-03 8/57 PRDX1; XCL1; LYST; HAVCR2; HLA-E; SH2D1A; GAPDH; CORO1A
GO:0070555 response to interleukin-1 5.49 8.51e-05 3.46e-03 8/58 GBP2; XCL1; SQSTM1; RORA; CCL5; CCL3; CCL3L3; KLF2
GO:0008037 cell recognition 5.38 2.12e-03 3.30e-02 5/37 HAVCR2; YWHAZ; CD9; LGALS3; CORO1A
GO:0034612 response to tumor necrosis factor 4.92 4.37e-06 3.21e-04 12/97 TNFRSF18; GBP2; XCL1; LTB; TMSB4X; GATA3; CD27; RORA; CCL5; CCL3; CCL3L3; KLF2
GO:0050900 leukocyte migration 4.85 3.10e-07 4.54e-05 15/123 TNFRSF18; CD2; XCL1; LYST; ITGA1; CD74; MYO1G; JAML; GATA3; LGALS3; CORO1A; CKLF; CCL5; CCL3; CCL3L3
GO:0050866 negative regulation of cell activation 4.80 5.55e-04 1.20e-02 7/58 XCL1; CD74; HAVCR2; CD9; LGALS3; SOCS1; SAMSN1
GO:0002449 lymphocyte mediated immunity 4.68 7.45e-06 4.96e-04 12/102 PRDX1; XCL1; LYST; CD74; HAVCR2; HLA-E; HLA-DQB1; MYO1G; SH2D1A; GATA3; CD27; CORO1A
GO:0070661 leukocyte proliferation 4.66 3.20e-06 2.93e-04 13/111 XCL1; LEF1; CD74; HAVCR2; HLA-E; HLA-DMB; HLA-DPA1; HLA-DPB1; CCND3; LGALS3; CORO1A; CCL5; TMIGD2
GO:0022407 regulation of cell-cell adhesion 4.56 4.85e-08 8.88e-06 18/157 XCL1; LEF1; CD74; HAVCR2; HLA-E; HLA-DMB; HLA-DPA1; HLA-DPB1; GATA3; ANK3; CD9; CD27; LGALS3; SOCS1; CORO1A; CCL5; TMIGD2; SPINT2
GO:0050663 cytokine secretion 4.42 9.21e-04 1.73e-02 7/63 CD2; HAVCR2; TMSB4X; GATA3; GAPDH; SOCS1; CCL3
GO:0045785 positive regulation of cell adhesion 4.22 8.57e-07 8.97e-05 16/151 TNFRSF18; S100A10; XCL1; CD74; HAVCR2; HLA-E; HLA-DMB; HLA-DPA1; HLA-DPB1; GATA3; ANK3; CD27; SOCS1; CORO1A; CCL5; TMIGD2
GO:0042110 T cell activation 4.09 1.03e-08 3.77e-06 22/214 TNFRSF18; CD2; XCL1; LEF1; TCF7; CD74; HAVCR2; HLA-E; HLA-DMB; HLA-DPA1; HLA-DPB1; CCND3; JAML; GATA3; CD27; LGALS3; RORA; SOCS1; LAT; CORO1A; CCL5; TMIGD2
GO:0010959 regulation of metal ion transport 3.98 3.81e-04 9.63e-03 9/90 XCL1; ANK3; LGALS3; CALM1; ANXA2; CORO1A; CCL5; CCL3; TSPO
GO:0019882 antigen processing and presentation 3.94 1.95e-04 6.65e-03 10/101 CD74; HLA-E; HLA-DRA; HLA-DRB5; HLA-DRB1; HLA-DQA1; HLA-DQB1; HLA-DMB; HLA-DPA1; HLA-DPB1
GO:0002440 production of molecular mediator of immune response 3.93 8.80e-04 1.73e-02 8/81 XCL1; GALNT2; CD74; HLA-E; HLA-DQB1; GATA3; TMIGD2; BST2
GO:0050867 positive regulation of cell activation 3.92 1.02e-05 6.25e-04 14/142 CD2; XCL1; CD74; HAVCR2; HLA-E; HLA-DMB; HLA-DPA1; HLA-DPB1; GATA3; CD27; SOCS1; CORO1A; CCL5; TMIGD2
GO:0002285 lymphocyte activation involved in immune response 3.82 2.20e-03 3.37e-02 7/73 LEF1; HAVCR2; HLA-DMB; GATA3; LGALS3; RORA; CORO1A
GO:0007162 negative regulation of cell adhesion 3.79 1.12e-03 2.05e-02 8/84 XCL1; CD74; HAVCR2; CD9; ARHGDIB; LGALS3; SOCS1; SPINT2
GO:0032103 positive regulation of response to external stimulus 3.70 1.31e-03 2.30e-02 8/86 XCL1; CD74; HAVCR2; HLA-E; TMSB4X; CCL5; CCL3; CCL3L3
GO:0007159 leukocyte cell-cell adhesion 3.62 2.60e-05 1.27e-03 14/154 XCL1; CD74; HAVCR2; HLA-E; HLA-DMB; HLA-DPA1; HLA-DPB1; GATA3; CD27; LGALS3; SOCS1; CORO1A; CCL5; TMIGD2
GO:1902600 proton transmembrane transport 3.62 2.99e-03 4.17e-02 7/77 COX5B; ATP5G3; COX7C; TMSB4X; SLC25A3; ATP5G1; MT-CO3
GO:0002694 regulation of leukocyte activation 3.62 8.20e-07 8.97e-05 19/209 TNFRSF18; CD2; XCL1; CD74; HAVCR2; HLA-E; HLA-DMB; HLA-DPA1; HLA-DPB1; GATA3; CD27; LGALS3; RORA; SOCS1; LAT; CORO1A; CCL5; TMIGD2; SAMSN1
GO:0050727 regulation of inflammatory response 3.55 8.93e-04 1.73e-02 9/101 XCL1; HLA-E; TMSB4X; GATA3; RORA; CCL5; CCL3; CCL3L3; GPX4
GO:0002250 adaptive immune response 3.52 6.86e-05 3.14e-03 13/147 XCL1; LEF1; CD74; HAVCR2; HLA-E; HLA-DQB1; MYO1G; SH2D1A; GATA3; CD27; RORA; LAT; SAMSN1
GO:0002791 regulation of peptide secretion 3.46 1.56e-04 5.71e-03 12/138 CD2; PASK; CD74; HAVCR2; HLA-E; TMSB4X; GATA3; GAPDH; SOCS1; CCL5; CCL3; PIM3
GO:0072507 divalent inorganic cation homeostasis 3.37 3.75e-04 9.63e-03 11/130 CD52; XCL1; EPHX2; ANK3; TPT1; CALM1; ANXA2; CORO1A; MT2A; CCL5; CCL3
GO:0001818 negative regulation of cytokine production 3.25 3.02e-03 4.17e-02 8/98 XCL1; LEF1; HAVCR2; TMSB4X; GATA3; KLF2; BST2; TSPO
GO:0050817 coagulation 3.22 3.21e-03 4.36e-02 8/99 CLIC1; ACTB; YWHAZ; GATA3; CD9; ANXA2; ACTG1; MYL12A
GO:0001819 positive regulation of cytokine production 3.15 2.10e-04 6.69e-03 13/164 CD2; XCL1; CD74; HAVCR2; HLA-E; LTB; HLA-DPA1; HLA-DPB1; GATA3; GAPDH; RORA; CCL3; TMIGD2
GO:0072511 divalent inorganic cation transport 3.06 2.52e-03 3.77e-02 9/117 XCL1; TPT1; LGALS3; CALM1; ANXA2; CORO1A; CCL5; CCL3; TSPO
GO:0009636 response to toxic substance 2.99 3.56e-04 9.63e-03 13/173 PRDX1; ACTB; EPHX2; GATA3; RGS10; CD27; CALM1; MT2A; CCL5; CCL3; GPX4; KLF2; MPST
GO:0051346 negative regulation of hydrolase activity 2.90 1.33e-03 2.30e-02 11/151 PPP1R2; SPINK2; LEF1; GZMA; TNFAIP8; SYTL2; CD27; GAPDH; LGALS3; BST2; SPINT2
GO:2000147 positive regulation of cell motility 2.84 1.56e-03 2.59e-02 11/154 TNFRSF18; XCL1; LEF1; CD74; TMSB4X; GATA3; LGALS3; CORO1A; PFN1; CCL5; CCL3
GO:0002764 immune response-regulating signaling pathway 2.82 2.40e-04 7.02e-03 15/212 HAVCR2; HLA-DRA; HLA-DRB5; HLA-DRB1; HLA-DQA1; HLA-DQB1; HLA-DPA1; HLA-DPB1; ACTB; MYO1G; GATA3; LGALS3; CALM1; LAT; ACTG1
GO:0009123 nucleoside monophosphate metabolic process 2.77 4.59e-04 1.12e-02 14/201 COX5B; ATP5G3; COX7C; UQCRQ; DNPH1; TMSB4X; PGM2L1; ADK; GAPDH; PKM; ATP5G1; TSPO; MT-ND1; MT-CO3
GO:0002521 leukocyte differentiation 2.76 4.83e-04 1.12e-02 14/202 TNFRSF18; CD2; CMTM7; LEF1; TCF7; CD74; GATA3; CD27; LGALS3; ANXA2; RORA; SOCS1; CCL3; JUNB
GO:0009141 nucleoside triphosphate metabolic process 2.71 9.17e-04 1.73e-02 13/191 COX5B; ATP5G3; COX7C; UQCRQ; TMSB4X; PGM2L1; ADK; GAPDH; PKM; ATP5G1; TSPO; MT-ND1; MT-CO3
GO:0009259 ribonucleotide metabolic process 2.31 1.87e-03 2.98e-02 15/258 COX5B; ATP5G3; COX7C; UQCRQ; TMSB4X; PGM2L1; HACD1; ADK; GAPDH; RORA; PKM; ATP5G1; TSPO; MT-ND1; MT-CO3
Factor 10 : 14 significant GO terms
GeneSet description enrichRatio pValue FDR GeneRatio geneSymbols
GO:0070972 protein localization to endoplasmic reticulum 9.32 0.00e+00 0.00e+00 25/121 RPL5; RPS27; RPL31; RPSA; RPL35A; RPL34; RPL37; RPS14; RPS18; RPL10A; RPL7; RPL8; RPL12; RPS3; RPS26; RPLP0; RPL21; RPS2; RPS15A; RPL23A; RPL38; RPS19; RPS9; RPS5; RPL3
GO:0048013 ephrin receptor signaling pathway 8.73 4.85e-05 3.23e-03 6/31 CDC42; ARPC2; ARPC4; ACTB; ARPC1B; ACTG1
GO:0006413 translational initiation 8.18 0.00e+00 0.00e+00 29/160 RPL5; RPS27; RPL31; RPSA; EIF2A; RPL35A; RPL34; RPL37; RPS14; NPM1; RPS18; RPL10A; EIF2S3; RPL7; PABPC1; RPL8; RPL12; RPS3; RPS26; RPLP0; RPL21; RPS2; RPS15A; RPL23A; RPL38; RPS19; RPS9; RPS5; RPL3
GO:0001906 cell killing 6.33 3.03e-05 2.27e-03 8/57 HMGN2; HLA-F; TUBB; HSP90AB1; TUBB4B; GAPDH; B2M; RPS19
GO:0090150 establishment of protein localization to membrane 6.19 1.55e-15 2.85e-13 28/204 RPL5; RPS27; RPL31; RPSA; RPL35A; RPL34; RPL37; RPS14; RPS18; RPL10A; RPL7; RPL8; RPL12; TIMM10; RPS3; RPS26; RPLP0; RPL21; CHP1; RPS2; RPS15A; YWHAE; RPL23A; RPL38; RPS19; RPS9; RPS5; RPL3
GO:0006401 RNA catabolic process 5.89 0.00e+00 0.00e+00 33/253 YBX1; RPL5; RPS27; RPL31; RQCD1; RPSA; RPL35A; RPL34; RPL37; RPS14; NPM1; RPS18; RPL10A; RPL7; PABPC1; RPL8; RPL12; SET; RPS3; VIM; RPS26; RPLP0; RPL21; HNRNPC; RPS2; RPS15A; UBB; RPL23A; RPL38; RPS19; RPS9; RPS5; RPL3
GO:0002181 cytoplasmic translation 5.49 3.09e-05 2.27e-03 9/74 RPL31; RPL35A; RPL10A; EIF2S3; RPL8; RPS26; RPLP0; RPL38; EEF2
GO:0006605 protein targeting 5.13 6.95e-14 1.02e-11 29/255 RPL5; RPS27; RPL31; HSPD1; RPSA; RPL35A; RPL34; RPL37; RPS14; RPS18; RPL10A; RPL7; RPL8; RPL12; TIMM10; RPS3; RPS26; RPLP0; RPL21; CHP1; RPS2; RPS15A; UBB; RPL23A; RPL38; RPS19; RPS9; RPS5; RPL3
GO:0006909 phagocytosis 4.62 1.23e-04 7.54e-03 9/88 CDC42; CDC42SE1; ARPC2; ARPC4; HSP90AB1; ACTB; ARPC1B; CD3G; ACTG1
GO:0071826 ribonucleoprotein complex subunit organization 4.06 6.32e-07 7.72e-05 17/189 RPL5; RPS27; RPSA; EIF2A; RPS14; NPM1; HSP90AB1; EIF2S3; RPL12; RPLP0; RPL23A; RPL38; RPS19; SNRPD2; GLTSCR2; RPS5; RPL3
GO:0010608 posttranscriptional regulation of gene expression 3.01 6.93e-06 6.35e-04 20/300 YBX1; RPL5; RQCD1; PASK; EIF2A; PPP3CA; RPS14; NPM1; RBM3; PABPC1; SET; RPS3; VIM; GAPDH; HNRNPC; EIF5A; UBB; RPL38; EEF2; RPS9
GO:0002764 immune response-regulating signaling pathway 2.98 2.12e-04 1.11e-02 14/212 CDC42; HSPD1; ARPC2; ARPC4; PPP3CA; HSP90AB1; ACTB; ARPC1B; RPS3; CD3D; CD3G; UBB; ACTG1; GLTSCR2
GO:0034248 regulation of cellular amide metabolic process 2.94 1.43e-04 8.05e-03 15/230 RPL5; RQCD1; PASK; EIF2A; RPS14; NPM1; RBM3; PABPC1; RPS3; VIM; GAPDH; EIF5A; RPL38; EEF2; RPS9
GO:0022613 ribonucleoprotein complex biogenesis 2.90 4.02e-06 4.20e-04 22/342 RPL5; RPS27; RPSA; EIF2A; RPL35A; RPS14; NPM1; RPL10A; HSP90AB1; EIF2S3; RPL7; RPL12; RPLP0; RPS2; RPL23A; RPL38; RPS19; SNRPD2; GLTSCR2; RPS9; RPS5; RPL3
Factor 13 : 90 significant GO terms
GeneSet description enrichRatio pValue FDR GeneRatio geneSymbols
GO:0042092 type 2 immune response 9.76 6.93e-05 1.34e-03 5/10 XCL1; CD74; ANXA1; GATA3; BATF
GO:0003170 heart valve development 6.50 2.41e-03 2.32e-02 4/12 RBPJ; SOX4; PRDM1; GATA3
GO:0006959 humoral immune response 6.50 1.06e-07 8.63e-06 12/36 HMGN2; CD55; GNLY; RBPJ; HLA-E; HLA-DQB1; SH2D1A; CD59; GATA3; RGCC; BST2; POU2F2
GO:1904019 epithelial cell apoptotic process 6.27 6.21e-06 1.82e-04 9/28 ITGA4; CFLAR; TNIP2; CAST; GATA3; RGCC; ZFP36L1; BCL2L1; STK4
GO:0032613 interleukin-10 production 6.10 9.31e-04 1.16e-02 5/16 FCER1G; XCL1; TIGIT; C10orf54; LGALS9
GO:0032633 interleukin-4 production 6.10 9.31e-04 1.16e-02 5/16 FCER1G; RBPJ; HLA-E; GATA3; LGALS9
GO:0034113 heterotypic cell-cell adhesion 6.10 9.31e-04 1.16e-02 5/16 ITGA4; CD44; ITGB7; MBP; ITGB2
GO:1990868 response to chemokine 5.85 3.60e-04 5.18e-03 6/20 XCL2; XCL1; FAM65B; CCL1; CCL5; CCL3
GO:0002437 inflammatory response to antigenic stimulus 5.74 1.26e-03 1.45e-02 5/17 FCER1G; RBPJ; HLA-E; IL2RA; GATA3
GO:0006968 cellular defense response 5.42 1.68e-03 1.76e-02 5/18 FCMR; GNLY; SH2D1A; LSP1; PRF1
GO:0032963 collagen metabolic process 5.14 2.18e-03 2.17e-02 5/19 F2R; MYB; VIM; C10orf54; RGCC
GO:0034341 response to interferon-gamma 5.05 1.18e-10 4.31e-08 22/85 GBP2; GBP5; XCL2; XCL1; HLA-E; HLA-DRA; HLA-DRB5; HLA-DRB1; HLA-DQA1; HLA-DQB1; HLA-DPA1; HLA-DPB1; IFITM2; CD44; VIM; B2M; LGALS9; CCL1; CCL5; CCL3; ACTG1; BST2
GO:0007229 integrin-mediated signaling pathway 4.88 1.53e-04 2.61e-03 8/32 FCER1G; ITGA4; TIMP1; ITGB7; LAT; ITGAL; ITGAE; ITGB2
GO:0098742 cell-cell adhesion via plasma-membrane adhesion molecules 4.88 2.79e-03 2.62e-02 5/20 SELL; ITGAL; MBP; FXYD5; ITGB2
GO:0046683 response to organophosphorus 4.59 2.42e-04 3.85e-03 8/34 JUN; SELL; LDHA; FDX1; HSP90B1; PEBP1; ZFP36L1; SOD1
GO:0002526 acute inflammatory response 4.55 6.30e-04 8.40e-03 7/30 FCER1G; CD55; HLA-E; CD59; GSTP1; GATA3; OSM
GO:0032612 interleukin-1 production 4.50 1.65e-03 1.76e-02 6/26 GBP5; F2R; ANXA1; GSTP1; LGALS9; CCL3
GO:0045445 myoblast differentiation 4.50 1.65e-03 1.76e-02 6/26 MBNL1; RBPJ; FAM65B; ZFP36L1; TNFSF14; LGALS1
GO:0060326 cell chemotaxis 4.36 1.72e-07 1.14e-05 17/76 FCER1G; XCL2; XCL1; CD74; FAM65B; TMSB4X; ANXA1; GSTP1; BIN2; LGALS3; LGALS9; CCL1; CCL5; CCL3; TNFSF14; CALR; ITGB2
GO:0050663 cytokine secretion 4.34 2.36e-06 8.25e-05 14/63 GBP5; RBPJ; F2R; TMSB4X; ANXA1; CRTAM; GATA3; SRGN; RGCC; LGALS9; CCL1; CCL3; MBP; OSM
GO:0014074 response to purine-containing compound 4.34 3.69e-04 5.20e-03 8/36 JUN; SELL; LDHA; FDX1; HSP90B1; PEBP1; ZFP36L1; SOD1
GO:0043062 extracellular structure organization 4.18 1.88e-05 4.31e-04 12/56 ITGA4; CFLAR; FSCN1; TIMP1; CD44; SPOCK2; ITGB7; RGCC; ERO1A; ITGAL; ITGAE; ITGB2
GO:0050920 regulation of chemotaxis 4.18 1.88e-05 4.31e-04 12/56 XCL2; XCL1; CD74; FAM65B; TMSB4X; GSTP1; LGALS9; CCL1; CCL5; CCL3; TNFSF14; CALR
GO:0001906 cell killing 4.11 2.28e-05 5.06e-04 12/57 HMGN2; XCL1; GNLY; IL7R; HLA-E; NCR3; SH2D1A; CTSC; CRTAM; PRF1; B2M; LGALS9
GO:0002440 production of molecular mediator of immune response 4.10 4.57e-07 2.39e-05 17/81 FCER1G; XCL1; CD55; GALNT2; CD96; IL7R; CD74; HLA-E; HLA-DQB1; MB21D1; ITM2A; GATA3; TMBIM6; BATF; B2M; BST2; POU2F2
GO:0032103 positive regulation of response to external stimulus 4.08 2.17e-07 1.32e-05 18/86 GBP5; FCER1G; XCL2; XCL1; CD74; FAM65B; HLA-E; TMSB4X; OPTN; NFKBIA; LGALS9; CCL1; CCL5; CCL3; TNFSF14; CALR; OSM; ITGB2
GO:0070555 response to interleukin-1 4.04 2.74e-05 5.91e-04 12/58 GBP2; XCL2; XCL1; TNIP2; ANXA1; NFKBIA; LGALS9; CCL1; CCL5; CCL3; AES; KLF2
GO:0071887 leukocyte apoptotic process 3.98 1.46e-04 2.55e-03 10/49 FCER1G; IL7R; CD74; ANXA1; IL2RA; CD27; LGALS3; LGALS9; CCL5; HSH2D
GO:0032609 interferon-gamma production 3.90 1.67e-03 1.76e-02 7/35 XCL1; CD96; HLA-DPA1; HLA-DPB1; GATA3; C10orf54; LGALS9
GO:0002449 lymphocyte mediated immunity 3.83 1.41e-07 1.04e-05 20/102 FCER1G; XCL1; CD55; CD96; IL7R; CD74; HLA-E; NCR3; HLA-DQB1; MYO1G; SH2D1A; CTSC; CRTAM; GATA3; PRF1; CD27; BATF; B2M; LGALS9; POU2F2
GO:0050900 leukocyte migration 3.81 8.25e-09 1.21e-06 24/123 FCER1G; XCL2; XCL1; SELL; GYPC; ITGA4; CD74; FAM65B; MYO1G; MSN; ANXA1; FUT7; CD44; GATA3; ITGB7; LGALS3; ITGAL; LGALS9; CCL1; CCL5; CCL3; TNFSF14; CALR; ITGB2
GO:0070371 ERK1 and ERK2 cascade 3.81 2.81e-06 8.95e-05 16/82 JUN; SLAMF1; XCL2; XCL1; CFLAR; F2R; CD74; RGS14; PRKCDBP; CD44; GSTP1; ZFP36L1; LGALS9; CCL1; CCL5; CCL3
GO:0002576 platelet degranulation 3.81 9.32e-04 1.16e-02 8/41 FCER1G; TTN; ANXA5; FAM3C; TMSB4X; TIMP1; SRGN; SOD1
GO:0050866 negative regulation of cell activation 3.70 1.37e-04 2.45e-03 11/58 XCL1; TIGIT; CD74; FAM65B; LST1; PAG1; ANXA1; IL2RA; C10orf54; LGALS3; LGALS9
GO:0002791 regulation of peptide secretion 3.68 4.16e-09 7.62e-07 26/138 GLUL; TTN; ITPR1; ANXA5; F2R; CD74; SOX4; HLA-E; SRI; TMSB4X; ANXA1; UCP2; CRTAM; GATA3; SRGN; TMBIM6; RGCC; GPR68; LGALS9; CCL1; CCL5; CCL3; MBP; KCNN4; OSM; PIM3
GO:0007159 leukocyte cell-cell adhesion 3.67 5.00e-10 1.22e-07 29/154 XCL1; SELL; CD55; ITGA4; TIGIT; IL7R; CD74; FAM65B; HLA-E; HLA-DMB; HLA-DPA1; HLA-DPB1; MYB; MSN; PAG1; ANXA1; CD44; IL2RA; GATA3; C10orf54; CD27; ITGB7; LGALS3; ITGAL; LGALS9; CCL5; TNFSF14; LGALS1; ITGB2
GO:0034612 response to tumor necrosis factor 3.62 1.43e-06 5.52e-05 18/97 TNFRSF9; GBP2; XCL2; XCL1; LTB; TMSB4X; TRAF1; GSTP1; GATA3; SGMS1; CD27; NFKBIA; ZFP36L1; CCL1; CCL5; CCL3; TNFSF14; KLF2
GO:0070661 leukocyte proliferation 3.52 5.99e-07 2.75e-05 20/111 XCL1; CD55; IL7R; CD74; HLA-E; LST1; HLA-DMB; HLA-DPA1; HLA-DPB1; MSN; ANXA1; GSTP1; CRTAM; IL2RA; C10orf54; LGALS3; LGALS9; CCL5; IKZF3; TNFSF14
GO:0007162 negative regulation of cell adhesion 3.48 1.80e-05 4.31e-04 15/84 XCL1; TIGIT; CD74; FAM65B; PAG1; ANXA1; LPXN; IL2RA; C10orf54; RGCC; LGALS3; LGALS9; MBP; FXYD5; LGALS1
GO:0048017 inositol lipid-mediated signaling 3.47 1.76e-03 1.82e-02 8/45 F2R; IER3; GATA3; ZFP36L1; PPP2R5C; CCL5; MYDGF; OSM
GO:0042110 T cell activation 3.47 5.06e-12 3.71e-09 38/214 FCER1G; XCL1; RAB29; CD55; TIGIT; IL7R; CD74; SOX4; FAM65B; HLA-E; HLA-DMB; HLA-DPA1; HLA-DPB1; MB21D1; PRDM1; MYB; MSN; PAG1; ANXA1; FUT7; CD3D; CRTAM; IL2RA; GATA3; C10orf54; CD27; LGALS3; ZFP36L1; BATF; B2M; LAT; ITGAL; LGALS9; CCL5; TNFSF14; HSH2D; LGALS1; SOD1
GO:0022407 regulation of cell-cell adhesion 3.36 1.63e-08 1.71e-06 27/157 XCL1; CD55; ITGA4; TIGIT; IL7R; CD74; FAM65B; HLA-E; HLA-DMB; HLA-DPA1; HLA-DPB1; MYB; PAG1; ANXA1; CD44; IL2RA; GATA3; C10orf54; CD27; RGCC; LGALS3; LGALS9; CCL5; MBP; TNFSF14; FXYD5; LGALS1
GO:0050727 regulation of inflammatory response 3.28 1.12e-05 2.84e-04 17/101 GBP5; FCER1G; XCL1; CD55; HLA-E; TMSB4X; ANXA1; CD59; GSTP1; IL2RA; GATA3; NFKBIA; CCL1; CCL5; CCL3; OSM; ITGB2
GO:0009914 hormone transport 3.21 8.69e-05 1.63e-03 14/85 GLUL; ITPR1; ANXA5; SOX4; MYB; SRI; PTPRN2; ANXA1; UCP2; GATA3; GPR68; CCL5; OSM; PIM3
GO:0002683 negative regulation of immune system process 3.19 8.90e-08 8.15e-06 26/159 FCER1G; XCL1; CD55; CD96; TIGIT; IL7R; CD74; FAM65B; HLA-E; LST1; PAG1; ANXA1; CD59; LPXN; IL2RA; C10orf54; TMBIM6; ELF1; NFKBIA; LGALS3; ZFP36L1; GPR68; KLF13; LGALS9; CCL3; BST2
GO:0002250 adaptive immune response 3.19 2.96e-07 1.67e-05 24/147 SLAMF1; FCER1G; XCL1; CD55; IL7R; CD74; HLA-E; HLA-DQB1; PRDM1; MYO1G; SH2D1A; PAG1; ANXA1; CTSC; CD3D; CRTAM; GATA3; PRF1; CD27; BATF; B2M; PRKCB; LAT; POU2F2
GO:0043588 skin development 3.19 3.08e-03 2.79e-02 8/49 TXNIP; RBPJ; LTB; AQP3; ANXA1; KRT7; ZFP36L1; STK4
GO:0051047 positive regulation of secretion 3.17 5.84e-06 1.79e-04 19/117 FCER1G; GLUL; TTN; F2R; SOX4; HLA-E; MYB; SRI; CRTAM; GATA3; RGCC; GPR68; LGALS9; CCL1; CCL3; MBP; KCNN4; OSM; ITGB2
GO:0038061 NIK/NF-kappaB signaling 3.14 1.93e-03 1.96e-02 9/56 REL; TMSB4X; CD27; NFKBIA; LITAF; LGALS9; TRAF4; TNFSF14; CALR
GO:0002237 response to molecule of bacterial origin 3.12 3.93e-05 8.23e-04 16/100 JUN; CD55; CD96; TNIP2; F2R; GSTP1; IL10RA; VIM; SGMS1; NFKBIA; B2M; LITAF; LGALS9; CCL5; CCL3; PTGIR
GO:0031032 actomyosin structure organization 3.12 3.51e-03 3.08e-02 8/50 EPB41; RHOC; S100A10; TTN; CFLAR; RGCC; PFN1; ACTG1
GO:0045785 positive regulation of cell adhesion 3.10 4.95e-07 2.42e-05 24/151 S100A10; XCL1; CD55; ITGA4; IL7R; CD74; HLA-E; HLA-DMB; HLA-DPA1; HLA-DPB1; MYB; ANXA1; NINJ1; CD44; IL2RA; GATA3; C10orf54; SPOCK2; CD27; LGALS9; CCL5; TNFSF14; CALR; LGALS1
GO:0002697 regulation of immune effector process 3.07 1.02e-06 4.15e-05 23/146 FCER1G; XCL1; CD55; CD96; IL7R; CD74; HLA-E; NCR3; HLA-DMB; MB21D1; MYB; SH2D1A; ANXA1; CD59; CRTAM; IL2RA; GATA3; TMBIM6; LGALS3; B2M; LGALS9; BST2; ITGB2
GO:0009743 response to carbohydrate 3.02 2.96e-04 4.52e-03 13/84 TXNIP; GLUL; SOX4; SRI; PTPRN2; LDHA; GSTP1; UCP2; ZFP36L1; GPR68; PRKCB; LGALS1; PIM3
GO:0072507 divalent inorganic cation homeostasis 3.00 7.73e-06 2.18e-04 20/130 CD52; XCL1; CD55; ITPR1; ANXA5; F2R; SRI; EPHX2; TMBIM6; ATP2B1; HSP90B1; TPT1; ERO1A; PRKCB; CCL1; CCL5; CCL3; S1PR4; CALR; PTGIR
GO:0002694 regulation of leukocyte activation 2.99 1.36e-08 1.66e-06 32/209 FCER1G; XCL1; CD55; TIGIT; TNIP2; IL7R; CD74; FAM65B; HLA-E; LST1; HLA-DMB; HLA-DPA1; HLA-DPB1; MB21D1; PRDM1; MYB; PAG1; ANXA1; IL2RA; GATA3; C10orf54; CD27; LGALS3; ZFP36L1; LAT; LGALS9; CCL5; IKZF3; TNFSF14; LGALS1; SOD1; ITGB2
GO:0001818 negative regulation of cytokine production 2.99 1.16e-04 2.12e-03 15/98 SLAMF1; XCL1; REL; CD96; TIGIT; TMSB4X; ANXA1; GSTP1; GATA3; SRGN; C10orf54; RGCC; LGALS9; KLF2; BST2
GO:0002285 lymphocyte activation involved in immune response 2.94 1.08e-03 1.28e-02 11/73 FCER1G; HLA-DMB; MYB; ITM2A; ANXA1; GATA3; LGALS3; BATF; ITGAL; LGALS9; LGALS1
GO:0019882 antigen processing and presentation 2.90 1.64e-04 2.74e-03 15/101 FCER1G; CD74; HLA-E; HLA-DRA; HLA-DRB5; HLA-DRB1; HLA-DQA1; HLA-DQB1; HLA-DMB; HLA-DPA1; HLA-DPB1; RAB33A; PSME1; B2M; CALR
GO:0050867 positive regulation of cell activation 2.89 8.62e-06 2.34e-04 21/142 FCER1G; XCL1; CD55; TNIP2; IL7R; CD74; HLA-E; HLA-DMB; HLA-DPA1; HLA-DPB1; MYB; ANXA1; IL2RA; GATA3; C10orf54; CD27; LGALS9; CCL5; TNFSF14; LGALS1; ITGB2
GO:0008544 epidermis development 2.88 3.53e-03 3.08e-02 9/61 TXNIP; RBPJ; FAM65B; AQP3; ANXA1; KRT7; ZFP36L1; STK4; SOD1
GO:1901654 response to ketone 2.88 3.53e-03 3.08e-02 9/61 TXNIP; CFLAR; MSN; FDX1; ATP2B1; PEBP1; BCL2L1; CALR; KLF2
GO:0043491 protein kinase B signaling 2.87 2.19e-03 2.17e-02 10/68 PRKCDBP; SESN3; GATA3; OSBPL8; ZFP36L1; HSP90AA1; CCL5; CCL3; MYDGF; OSM
GO:0001819 positive regulation of cytokine production 2.86 2.31e-06 8.25e-05 24/164 GBP5; FCER1G; XCL1; TIGIT; F2R; CD74; HLA-E; LTB; HLA-DPA1; HLA-DPB1; MB21D1; MYB; HILPDA; ANXA1; CRTAM; GATA3; RGCC; B2M; LGALS9; CCL1; CCL3; MBP; OSM; SOD1
GO:1904950 negative regulation of establishment of protein localization 2.83 2.45e-03 2.33e-02 10/69 ANXA5; F2R; MDFIC; TMSB4X; ANXA1; UCP2; SRGN; TMBIM6; RGCC; PIM3
GO:2000147 positive regulation of cell motility 2.79 9.28e-06 2.43e-04 22/154 JUN; RHOC; XCL2; XCL1; ITGA4; F2R; CD74; FAM65B; TMSB4X; ANXA1; RRAS2; GATA3; C10orf54; SPOCK2; LGALS3; PFN1; LGALS9; CCL1; CCL5; CCL3; TNFSF14; CALR
GO:0051235 maintenance of location 2.71 2.18e-04 3.55e-03 16/115 XCL1; TMSB10; ITPR1; ANXA5; F2R; SRI; HILPDA; TMSB4X; PLIN2; SRGN; OSBPL8; HSP90B1; NFKBIA; ERO1A; CCL3; CALR
GO:0023061 signal release 2.71 3.50e-04 5.18e-03 15/108 GLUL; ITPR1; ANXA5; SOX4; MYB; SRI; PTPRN2; ANXA1; UCP2; GATA3; GPR68; PRKCB; CCL5; OSM; PIM3
GO:0002521 leukocyte differentiation 2.70 9.79e-07 4.15e-05 28/202 JUN; FCER1G; ITGA4; RBPJ; IL7R; CD74; SOX4; PRDM1; MYB; ITM2A; ANXA1; FUT7; CD3D; IL2RA; GATA3; C10orf54; CD27; LGALS3; ZFP36L1; BATF; GPR68; B2M; LGALS9; CCL3; IKZF3; POU2F2; LGALS1; SOD1
GO:0072511 divalent inorganic cation transport 2.67 2.67e-04 4.17e-03 16/117 XCL1; BIN1; ITPR1; ANXA5; F2R; SRI; ORAI2; TMBIM6; ATP2B1; TPT1; ERO1A; LGALS3; PRKCB; CCL5; CCL3; KCNN4
GO:0006909 phagocytosis 2.66 1.60e-03 1.76e-02 12/88 CDC42SE1; SLAMF1; FCER1G; LYAR; MYO1G; ANXA1; BIN2; HSP90AA1; ITGAL; ACTG1; CALR; ITGB2
GO:0031589 cell-substrate adhesion 2.66 1.60e-03 1.76e-02 12/88 S100A10; ITGA4; CD96; MYO1G; NINJ1; CD44; SPOCK2; ITGB7; ITGAL; CALR; LGALS1; ITGB2
GO:0051051 negative regulation of transport 2.62 6.01e-05 1.19e-03 20/149 BIN1; ANXA5; F2R; CD74; SRI; MDFIC; TMSB4X; ANXA1; UCP2; SRGN; TMBIM6; RGCC; TBC1D4; LGALS3; PRKCB; LGALS9; OAZ1; BST2; OSM; PIM3
GO:0048872 homeostasis of number of cells 2.60 3.59e-04 5.18e-03 16/120 FCER1G; LYAR; IL7R; F2R; CD74; ANXA1; IL2RA; GATA3; ZFP36L1; KLF13; B2M; LAT; LGALS9; TNFSF14; KLF2; SOD1
GO:0097305 response to alcohol 2.60 4.55e-03 3.67e-02 10/75 GSTP1; FDX1; GATA3; CD27; ATP2B1; PEBP1; CCL3; BCL2L1; KLF2; SOD1
GO:0002764 immune response-regulating signaling pathway 2.58 2.63e-06 8.75e-05 28/212 JUN; FCER1G; RAB29; TNIP2; NCR3; HLA-DRA; HLA-DRB5; HLA-DRB1; HLA-DQA1; HLA-DQB1; HLA-DPA1; HLA-DPB1; MYO1G; PAG1; LPXN; CD3D; GATA3; HSP90B1; ELF1; NFKBIA; LGALS3; HSP90AA1; PRKCB; LAT; LGALS9; ACTG1; KCNN4; ITGB2
GO:0051271 negative regulation of cellular component movement 2.57 5.01e-03 3.87e-02 10/76 BIN1; FAM65B; TIMP1; GSTP1; GATA3; OSBPL8; RGCC; LDLRAD4; CALR; BST2
GO:0071216 cellular response to biotic stimulus 2.57 5.01e-03 3.87e-02 10/76 TXNIP; CD55; TNIP2; GSTP1; VIM; SGMS1; NFKBIA; LITAF; CCL5; CCL3
GO:1903706 regulation of hemopoiesis 2.51 4.96e-05 1.01e-03 22/171 JUN; IL7R; CD74; PRDM1; MYB; ANXA1; IL2RA; GATA3; C10orf54; CD27; NFKBIA; LGALS3; ZFP36L1; GPR68; KLF13; B2M; PRKCB; LGALS9; CCL3; IKZF3; LGALS1; SOD1
GO:0042113 B cell activation 2.51 1.21e-03 1.41e-02 14/109 ITGA4; TNIP2; RBPJ; IL7R; CD74; ITM2A; CD27; ZFP36L1; BATF; PRKCB; IKZF3; BST2; POU2F2; LGALS1
GO:0007249 I-kappaB kinase/NF-kappaB signaling 2.48 6.25e-04 8.40e-03 16/126 RHOC; S100A4; REL; CFLAR; TNIP2; F2R; CD74; EEF1D; GSTP1; OPTN; NFKBIA; LITAF; PRKCB; LGALS9; BST2; LGALS1
GO:0003013 circulatory system process 2.44 4.93e-03 3.87e-02 11/88 XCL2; BIN1; TTN; ITPR1; F2R; SRI; EPHX2; ATP2B1; PEBP1; SCPEP1; SOD1
GO:0001667 ameboidal-type cell migration 2.37 2.98e-03 2.77e-02 13/107 JUN; GLUL; ITGA4; TMSB4X; TIMP1; ZFAND5; ANXA1; GATA3; ITGB7; RGCC; PFN1; CALR; ITGB2
GO:0051346 negative regulation of hydrolase activity 2.33 6.28e-04 8.40e-03 18/151 CDC42SE1; BIN1; CFLAR; PPP1R2; CAST; TNFAIP8; PTPRN2; TIMP1; ANXA1; CD44; SPOCK2; CD27; TMBIM6; PEBP1; LGALS3; TNFSF14; CDKN2D; BST2
GO:0045861 negative regulation of proteolysis 2.28 3.06e-03 2.79e-02 14/120 CD55; BIN1; CFLAR; CAST; TNFAIP8; TIMP1; CD59; CD44; SPOCK2; CD27; PEBP1; TNFSF14; CDKN2D; BST2
GO:0052547 regulation of peptidase activity 2.24 1.00e-03 1.20e-02 18/157 BIN1; CFLAR; F2R; CAST; TNFAIP8; TIMP1; CD44; C10orf54; SPOCK2; CD27; PEBP1; PSME1; PSME2; LGALS9; MBP; TNFSF14; CDKN2D; BST2
GO:0007568 aging 2.19 4.45e-03 3.62e-02 14/125 JUN; NPM1; HMGA1; MB21D1; TIMP1; UCP2; CTSC; ATP2B1; PEBP1; ERO1A; LITAF; CALR; SOD1; ITGB2
GO:0046677 response to antibiotic 2.19 4.45e-03 3.62e-02 14/125 JUN; TXNIP; MYB; ANXA1; LDHA; GSTP1; FDX1; GATA3; CD27; PEBP1; HSP90AA1; BCL2L1; KLF2; SOD1
GO:0031349 positive regulation of defense response 2.13 2.40e-03 2.32e-02 17/156 GBP5; FCER1G; TNIP2; HLA-E; NCR3; MB21D1; SH2D1A; CRTAM; OPTN; HSP90B1; NFKBIA; LGALS9; CCL1; CCL5; CCL3; OSM; ITGB2
GO:0043087 regulation of GTPase activity 2.02 4.06e-03 3.42e-02 17/164 JUN; CDC42SE1; S100A10; XCL2; XCL1; RGS1; F2R; RGS14; TAGAP; PTPRN2; ARHGEF6; TBC1D4; CCL1; CCL5; CCL3; STMN3; SOD1
Factor 14 : 77 significant GO terms
GeneSet description enrichRatio pValue FDR GeneRatio geneSymbols
GO:0032633 interleukin-4 production 13.10 3.67e-07 1.58e-05 7/16 FCER1G; CD28; RBPJ; LEF1; NDFIP1; IRF4; GATA3
GO:0042092 type 2 immune response 12.00 2.16e-04 3.53e-03 4/10 NDFIP1; CD74; ANXA1; GATA3
GO:0071800 podosome assembly 10.90 3.31e-04 5.17e-03 4/11 CAPG; CSF2; FSCN1; LCP1
GO:0055094 response to lipoprotein particle 9.97 4.84e-04 7.10e-03 4/12 FCER1G; HMGCS1; CD9; ITGB2
GO:0071402 cellular response to lipoprotein particle stimulus 9.97 4.84e-04 7.10e-03 4/12 FCER1G; HMGCS1; CD9; ITGB2
GO:0001773 myeloid dendritic cell activation 9.35 1.28e-04 2.46e-03 5/16 BATF3; RBPJ; CSF2; IRF4; FLT3LG
GO:0007200 phospholipase C-activating G protein-coupled receptor signaling pathway 8.97 3.71e-03 3.91e-02 3/10 S1PR1; F2R; LPAR6
GO:0002437 inflammatory response to antigenic stimulus 8.80 1.76e-04 3.07e-03 5/17 FCER1G; CD28; RBPJ; IL2RA; GATA3
GO:0006720 isoprenoid metabolic process 7.48 1.04e-04 2.12e-03 6/24 FDPS; HMGCS1; FDFT1; IDI1; MVK; MVD
GO:0006968 cellular defense response 6.65 2.56e-03 3.02e-02 4/18 TNFRSF4; GNLY; LSP1; PRF1
GO:0032623 interleukin-2 production 6.54 6.85e-05 1.48e-03 7/32 FCER1G; SPTBN1; CD28; IRF4; ANXA1; GATA3; LAG3
GO:1903034 regulation of response to wounding 6.19 3.20e-04 5.10e-03 6/29 FCER1G; F2R; ANXA1; UBASH3B; CD9; XBP1
GO:0098742 cell-cell adhesion via plasma-membrane adhesion molecules 5.98 3.84e-03 3.91e-02 4/20 SELL; ITGAL; FXYD5; ITGB2
GO:1990868 response to chemokine 5.98 3.84e-03 3.91e-02 4/20 FAM65B; CXCR3; CCL5; CCL4L2
GO:0006959 humoral immune response 5.81 1.52e-04 2.85e-03 7/36 CD55; GNLY; CD28; RBPJ; HLA-DQB1; GATA3; POU2F2
GO:0002285 lymphocyte activation involved in immune response 5.74 8.47e-08 4.84e-06 14/73 FCER1G; CD28; FOXP1; LEF1; NDFIP1; IRF4; HLA-DMB; ITM2A; ANXA1; GATA3; LCP1; ITGAL; ADA; XBP1
GO:0070661 leukocyte proliferation 5.66 5.14e-11 6.28e-09 21/111 TNFRSF4; CD55; CD28; CD38; LEF1; IL7R; IL6ST; NDFIP1; CD74; HLA-DMB; HLA-DPA1; HLA-DPB1; FYN; ANXA1; IL2RA; CCL5; IKZF3; ADA; TMIGD2; TNFSF14; FLT3LG
GO:0022407 regulation of cell-cell adhesion 5.52 1.35e-14 9.93e-12 29/157 CD55; ITGA4; CD28; ICOS; LEF1; IL7R; IL6ST; NDFIP1; CD74; FAM65B; HLA-DMB; HLA-DPA1; HLA-DPB1; FYN; ANXA1; CD44; UBASH3B; IL2RA; GATA3; CD9; LAG3; TESPA1; SOCS1; CCL5; ADA; TMIGD2; TNFSF14; FXYD5; XBP1
GO:0071887 leukocyte apoptotic process 5.49 2.74e-05 6.09e-04 9/49 TNFRSF4; FCER1G; FOXP1; IL7R; CD74; ANXA1; IL2RA; CCL5; ADA
GO:0007159 leukocyte cell-cell adhesion 5.44 6.24e-14 2.29e-11 28/154 SELL; CD55; ITGA4; CD28; ICOS; IL7R; IL6ST; NDFIP1; CD74; FAM65B; HLA-DMB; HLA-DPA1; HLA-DPB1; FYN; ANXA1; CD44; IL2RA; GATA3; LAG3; TESPA1; SOCS1; ITGAL; CCL5; ADA; TMIGD2; TNFSF14; XBP1; ITGB2
GO:0043062 extracellular structure organization 5.34 1.26e-05 3.14e-04 10/56 CAPG; ITGA4; ITGA1; FSCN1; CD44; LCP1; ITGAL; ICAM2; ITGB2; COL6A2
GO:0002449 lymphocyte mediated immunity 5.28 4.39e-09 3.22e-07 18/102 SLAMF7; FCER1G; CD55; CD28; IL7R; NDFIP1; CD74; NCR3; HLA-DQB1; CTSC; GATA3; PRF1; LAG3; KLRD1; B2M; CTSH; GZMM; POU2F2
GO:0034341 response to interferon-gamma 5.28 9.21e-08 4.84e-06 15/85 TXK; IRF4; HLA-DRA; HLA-DRB5; HLA-DRB1; HLA-DQA1; HLA-DQB1; HLA-DPA1; HLA-DPB1; CD44; B2M; SOCS1; MT2A; CCL5; CCL4L2
GO:0050867 positive regulation of cell activation 5.27 3.40e-12 6.23e-10 25/142 TNFRSF4; FCER1G; CD55; CD28; ICOS; CD38; IL7R; IL6ST; CD74; HLA-DMB; HLA-DPA1; HLA-DPB1; FYN; ANXA1; IL2RA; GATA3; TESPA1; SOCS1; CCL5; ADA; TMIGD2; TNFSF14; FLT3LG; XBP1; ITGB2
GO:0001906 cell killing 5.25 1.48e-05 3.48e-04 10/57 SLAMF7; GNLY; IL7R; NCR3; CTSC; PRF1; LAG3; B2M; CTSH; GZMM
GO:0050663 cytokine secretion 5.22 5.74e-06 1.68e-04 11/63 TNFRSF4; SPTBN1; FOXP1; RBPJ; F2R; TMSB4X; ANXA1; GATA3; SOCS1; XBP1; OSM
GO:0002440 production of molecular mediator of immune response 5.17 3.31e-07 1.51e-05 14/81 TNFRSF4; FCER1G; CD55; CD28; IL7R; NDFIP1; CD74; HLA-DQB1; ITM2A; GATA3; B2M; TMIGD2; POU2F2; XBP1
GO:0060326 cell chemotaxis 5.12 1.00e-06 3.88e-05 13/76 S1PR1; FCER1G; LEF1; ITGA1; CD74; FAM65B; TMSB4X; CXCR3; ANXA1; CCL5; CCL4L2; TNFSF14; ITGB2
GO:0050727 regulation of inflammatory response 5.03 2.55e-08 1.70e-06 17/101 FCER1G; CD55; CD28; FOXP1; IL6ST; NDFIP1; TMSB4X; ANXA1; BIRC3; IL2RA; GATA3; PDCD4; MVK; CCL5; ADA; OSM; ITGB2
GO:0008202 steroid metabolic process 4.98 2.03e-07 9.90e-06 15/90 DHCR24; FDPS; MSMO1; HMGCS1; ACAT2; INSIG1; EBP; FDFT1; SQLE; DHCR7; IDI1; SCD; MVK; C14orf1; MVD
GO:0097696 STAT cascade 4.98 1.59e-04 2.92e-03 8/48 IL7R; IL6ST; F2R; CSF2; FYN; SOCS1; CCL5; OSM
GO:0002526 acute inflammatory response 4.98 2.85e-03 3.26e-02 5/30 FCER1G; CD55; IL6ST; GATA3; OSM
GO:0048771 tissue remodeling 4.85 1.26e-03 1.62e-02 6/37 S1PR1; CD38; RBPJ; F2R; ANXA1; UBASH3B
GO:0060541 respiratory system development 4.72 1.45e-03 1.83e-02 6/38 RBPJ; LEF1; DHCR7; CTSH; ADA; KLF2
GO:0007229 integrin-mediated signaling pathway 4.67 3.81e-03 3.91e-02 5/32 FCER1G; ITGA4; ITGA1; ITGAL; ITGB2
GO:0048017 inositol lipid-mediated signaling 4.65 6.40e-04 9.03e-03 7/45 CD28; F2R; FYN; GATA3; CCL5; HCST; OSM
GO:0050866 negative regulation of cell activation 4.64 1.10e-04 2.17e-03 9/58 NDFIP1; CD74; FAM65B; ANXA1; UBASH3B; IL2RA; CD9; LAG3; SOCS1
GO:0045785 positive regulation of cell adhesion 4.56 5.68e-10 5.94e-08 23/151 S100A10; CD55; ITGA4; CD28; ICOS; IL7R; IL6ST; CD74; HLA-DMB; HLA-DPA1; HLA-DPB1; FYN; ANXA1; CD44; IL2RA; GATA3; TESPA1; SOCS1; CCL5; ADA; TMIGD2; TNFSF14; XBP1
GO:0032103 positive regulation of response to external stimulus 4.52 4.28e-06 1.36e-04 13/86 S1PR1; FCER1G; CD28; IL6ST; CD74; FAM65B; TMSB4X; PDCD4; CCL5; CCL4L2; TNFSF14; OSM; ITGB2
GO:0002250 adaptive immune response 4.48 1.97e-09 1.60e-07 22/147 SLAMF7; FCER1G; CD55; CD28; TXK; LEF1; IL7R; IL6ST; NDFIP1; CD74; IRF4; HLA-DQB1; FYN; ANXA1; CTSC; GATA3; PRF1; B2M; CTSH; ADA; GZMM; POU2F2
GO:0042110 T cell activation 4.47 2.50e-13 6.11e-11 32/214 TNFRSF4; FCER1G; CD55; CD28; ICOS; FOXP1; LEF1; IL7R; IL6ST; TCF7; NDFIP1; CD74; IRF4; FAM65B; HLA-DMB; HLA-DPA1; HLA-DPB1; FYN; ANXA1; IL2RA; GATA3; LAG3; TESPA1; LCP1; B2M; SOCS1; ITGAL; CCL5; ADA; TMIGD2; TNFSF14; XBP1
GO:0050900 leukocyte migration 4.38 9.23e-08 4.84e-06 18/123 S1PR1; FCER1G; SELL; ITGA4; ITGA1; CD74; FAM65B; FYN; CXCR3; ANXA1; CD44; GATA3; ITGAL; CCL5; CCL4L2; ADA; TNFSF14; ITGB2
GO:0002694 regulation of leukocyte activation 4.29 4.63e-12 6.79e-10 30/209 TNFRSF4; FCER1G; CD55; CD28; ICOS; CD38; IL7R; IL6ST; NDFIP1; CD74; IRF4; FAM65B; HLA-DMB; HLA-DPA1; HLA-DPB1; FYN; ANXA1; IL2RA; GATA3; LAG3; TESPA1; SOCS1; CCL5; IKZF3; ADA; TMIGD2; TNFSF14; FLT3LG; XBP1; ITGB2
GO:0019882 antigen processing and presentation 4.15 5.19e-06 1.58e-04 14/101 FCER1G; KIF2A; CD74; HLA-DRA; HLA-DRB5; HLA-DRB1; HLA-DQA1; HLA-DQB1; HLA-DMB; HLA-DPA1; HLA-DPB1; LAG3; B2M; CTSH
GO:0007162 negative regulation of cell adhesion 3.92 9.42e-05 1.97e-03 11/84 NDFIP1; CD74; FAM65B; ANXA1; UBASH3B; IL2RA; CD9; LAG3; ARHGDIB; SOCS1; FXYD5
GO:0002521 leukocyte differentiation 3.85 1.70e-09 1.56e-07 26/202 FCER1G; BATF3; ITGA4; CD28; FOXP1; RBPJ; LEF1; IL7R; CSF2; TCF7; NDFIP1; CD74; IRF4; ITM2A; ANXA1; UBASH3B; IL2RA; GATA3; TESPA1; B2M; SOCS1; IKZF3; ADA; POU2F2; FLT3LG; XBP1
GO:0042113 B cell activation 3.84 1.28e-05 3.14e-04 14/109 TNFRSF4; ITGA4; CD28; CD38; RBPJ; LEF1; IL7R; NDFIP1; CD74; ITM2A; IKZF3; ADA; POU2F2; XBP1
GO:0019216 regulation of lipid metabolic process 3.80 3.49e-06 1.16e-04 16/126 FDPS; CISH; HMGCS1; PLPP1; INSIG1; FDFT1; SQLE; ANXA1; FADS1; DHCR7; IDI1; SCD; GLIPR1; MVK; SOCS1; MVD
GO:1901615 organic hydroxy compound metabolic process 3.74 2.12e-06 7.41e-05 17/136 DHCR24; FDPS; MSMO1; HMGCS1; ACAT2; INSIG1; EBP; FDFT1; SQLE; DHCR7; IDI1; GATA3; SCD; MVK; C14orf1; MVD; ITGB2
GO:0050920 regulation of chemotaxis 3.74 2.40e-03 2.89e-02 7/56 S1PR1; CD74; FAM65B; TMSB4X; CCL5; CCL4L2; TNFSF14
GO:0048872 homeostasis of number of cells 3.74 8.72e-06 2.28e-04 15/120 TNFRSF4; FCER1G; LYAR; IL7R; F2R; CD74; ANXA1; IL2RA; GATA3; B2M; RPS17; ADA; TNFSF14; KLF2; FLT3LG
GO:0002697 regulation of immune effector process 3.69 1.28e-06 4.70e-05 18/146 TNFRSF4; FCER1G; CD55; CD28; IL7R; NDFIP1; CD74; IRF4; NCR3; HLA-DMB; ANXA1; BIRC3; IL2RA; GATA3; LAG3; B2M; XBP1; ITGB2
GO:1903706 regulation of hemopoiesis 3.50 7.47e-07 3.04e-05 20/171 H3F3A; CD28; FOXP1; LEF1; IL7R; CSF2; NDFIP1; CD74; IRF4; ANXA1; UBASH3B; IL2RA; GATA3; TESPA1; B2M; SOCS1; IKZF3; ADA; FLT3LG; XBP1
GO:0006644 phospholipid metabolic process 3.39 1.52e-05 3.48e-04 16/141 FDPS; CD28; ICOS; CISH; HMGCS1; PLPP1; SERINC5; FYN; FDFT1; FADS1; RARRES3; IDI1; MVK; SOCS1; MVD; FLT3LG
GO:0010959 regulation of metal ion transport 3.32 7.58e-04 1.05e-02 10/90 F2R; FYN; SARAF; AHNAK; UBASH3B; GSTO1; B2M; CCL5; CCL4L2; FXYD5
GO:0001819 positive regulation of cytokine production 3.28 6.96e-06 1.89e-04 18/164 FCER1G; SPTBN1; CD28; TXK; IL6ST; F2R; CSF2; CD74; IRF4; HLA-DPA1; HLA-DPB1; ANXA1; BIRC3; GATA3; B2M; TMIGD2; XBP1; OSM
GO:0048568 embryonic organ development 3.15 1.16e-03 1.55e-02 10/95 RBPJ; LEF1; CSF2; TCF7; FAM65B; INSIG1; RPL10; GATA3; ADA; FLT3LG
GO:0032102 negative regulation of response to external stimulus 3.15 3.60e-03 3.91e-02 8/76 NDFIP1; UBASH3B; IL2RA; GATA3; PDCD4; CD9; MVK; ADA
GO:0002791 regulation of peptide secretion 3.03 1.81e-04 3.08e-03 14/138 TNFRSF4; SPTBN1; FOXP1; CD38; F2R; CD74; TMSB4X; RAB11FIP1; ANXA1; GATA3; SOCS1; CCL5; XBP1; OSM
GO:0062012 regulation of small molecule metabolic process 2.99 3.56e-04 5.44e-03 13/130 FDPS; HMGCS1; INSIG1; TMSB4X; FDFT1; SQLE; ANXA1; DHCR7; IDI1; DDIT4; SCD; MVK; MVD
GO:0002764 immune response-regulating signaling pathway 2.96 5.97e-06 1.68e-04 21/212 FCER1G; CD28; CD38; TXK; IRF4; NCR3; HLA-DRA; HLA-DRB5; HLA-DRB1; HLA-DQA1; HLA-DQB1; HLA-DPA1; HLA-DPB1; FYN; BIRC3; GATA3; TESPA1; CTSH; ICAM2; ADA; ITGB2
GO:2000147 positive regulation of cell motility 2.91 1.68e-04 3.00e-03 15/154 S1PR1; ITGA4; FOXP1; LEF1; F2R; CD74; FAM65B; TMSB4X; ANXA1; GATA3; CTSH; CCL5; CCL4L2; TNFSF14; XBP1
GO:0031349 positive regulation of defense response 2.88 1.94e-04 3.23e-03 15/156 PYHIN1; FCER1G; CD28; TXK; IL6ST; IRF4; NCR3; FYN; BIRC3; PDCD4; LAG3; CCL5; ICAM2; OSM; ITGB2
GO:0048871 multicellular organismal homeostasis 2.88 2.31e-03 2.83e-02 10/104 S1PR1; CD38; RBPJ; F2R; IRF4; UBASH3B; SCD; B2M; CTSH; FLT3LG
GO:0034612 response to tumor necrosis factor 2.77 4.83e-03 4.74e-02 9/97 TNFRSF4; TMSB4X; BIRC3; GATA3; CCL5; CCL4L2; CD70; TNFSF14; KLF2
GO:0032970 regulation of actin filament-based process 2.76 1.94e-03 2.41e-02 11/119 S1PR1; S100A10; SPTBN1; TMSB10; CAPG; ARHGAP18; FSCN1; TMSB4X; ADD3; ARHGDIB; GMFG
GO:0072507 divalent inorganic cation homeostasis 2.76 1.23e-03 1.61e-02 12/130 S1PR1; CD55; CD38; F2R; FYN; CXCR3; UBASH3B; GSTO1; LPAR6; MT2A; MT1E; CCL5
GO:0001101 response to acid chemical 2.75 5.17e-03 4.92e-02 9/98 CD38; FYN; SESN3; SCD; CD9; CTSH; SOCS1; KLF2; XBP1
GO:0001818 negative regulation of cytokine production 2.75 5.17e-03 4.92e-02 9/98 TNFRSF4; LEF1; NDFIP1; TMSB4X; ANXA1; GATA3; PDCD4; LAG3; KLF2
GO:0018212 peptidyl-tyrosine modification 2.69 3.74e-03 3.91e-02 10/111 TXK; IL6ST; CSF2; CD74; FYN; CD44; SOCS1; CCL5; OSM; ITGB2
GO:0030099 myeloid cell differentiation 2.64 4.96e-04 7.12e-03 15/170 FCER1G; BATF3; H3F3A; FOXP1; LYAR; RBPJ; LEF1; CSF2; NDFIP1; CD74; IRF4; UBASH3B; GATA3; B2M; KLF2
GO:0002683 negative regulation of immune system process 2.63 7.82e-04 1.06e-02 14/159 TNFRSF4; FCER1G; CD55; IL7R; NDFIP1; CD74; IRF4; FAM65B; ANXA1; UBASH3B; IL2RA; LAG3; SOCS1; ADA
GO:0007015 actin filament organization 2.57 3.46e-03 3.90e-02 11/128 S1PR1; S100A10; SPTBN1; TMSB10; CAPG; ARHGAP18; FSCN1; TMSB4X; ADD3; LCP1; GMFG
GO:0090066 regulation of anatomical structure size 2.53 2.63e-03 3.06e-02 12/142 SPTBN1; TMSB10; CAPG; CD38; IL7R; ITGA1; F2R; HRH2; ARHGAP18; TMSB4X; ADD3; GMFG
GO:0051346 negative regulation of hydrolase activity 2.38 4.36e-03 4.38e-02 12/151 DHCR24; LEF1; GZMA; TNFAIP8; SERPINB1; SERPINB6; ANXA1; CD44; SYTL2; BIRC3; CST7; TNFSF14
GO:0045088 regulation of innate immune response 2.35 4.85e-03 4.74e-02 12/153 PYHIN1; FCER1G; TXK; IRF4; NCR3; FYN; BIRC3; LAG3; SOCS1; CCL5; ICAM2; ITGB2
GO:0043900 regulation of multi-organism process 2.33 3.63e-03 3.91e-02 13/167 CD55; CD28; FOXP1; LEF1; CD74; BIRC3; IL2RA; PRF1; ARHGDIB; CCL5; CCL4L2; ADA; APOBEC3H
Factor 15 : 38 significant GO terms
GeneSet description enrichRatio pValue FDR GeneRatio geneSymbols
GO:2000241 regulation of reproductive process 13.40 1.95e-04 5.72e-03 4/32 CDC20; ASPM; FBXO5; CALR
GO:0007292 female gamete generation 13.10 3.26e-05 1.26e-03 5/41 ASPM; CCNB1; FBXO5; BRCA2; PLK1
GO:0051321 meiotic cell cycle 13.00 4.81e-11 8.81e-09 12/99 CDC20; NUF2; ASPM; NEK2; MSH6; PTTG1; FBXO5; XRCC2; H2AFX; BRCA2; PLK1; CALR
GO:0034502 protein localization to chromosome 12.80 8.97e-07 4.11e-05 7/59 HIST1H1B; ESCO2; CDCA5; BRCA2; PLK1; CTCF; CDT1
GO:0036297 interstrand cross-link repair 11.50 2.10e-03 4.16e-02 3/28 NUCKS1; MSH6; UBC
GO:0006984 ER-nucleus signaling pathway 11.10 2.33e-03 4.48e-02 3/29 HSPA5; HSP90B1; CALR
GO:0006333 chromatin assembly or disassembly 10.20 1.51e-07 9.23e-06 9/95 H1FX; NPM1; HIST1H1A; HIST1H1C; HIST1H1E; HIST1H1D; HIST1H1B; H2AFX; CTCF
GO:0006310 DNA recombination 9.90 3.95e-11 8.81e-09 14/152 NUCKS1; MSH6; H1FX; HIST1H1A; HIST1H1C; HIST1H1E; HIST1H1D; HIST1H1B; XRCC2; H2AFX; UNG; BRCA2; GINS2; KPNA2
GO:0010948 negative regulation of cell cycle process 8.70 2.29e-10 2.80e-08 14/173 CDC20; NEK2; DTL; RRM2; MSH6; MAD2L1; CCNB1; PTTG1; NPM1; FBXO5; PLK1; CDT1; CDKN2D; CALR
GO:0071103 DNA conformation change 8.66 5.95e-09 5.45e-07 12/149 H1FX; CCNB1; NPM1; HIST1H1A; HIST1H1C; HIST1H1E; HIST1H1D; HIST1H1B; CDCA5; H2AFX; CTCF; GINS2
GO:1904029 regulation of cyclin-dependent protein kinase activity 8.60 1.11e-03 2.53e-02 4/50 CCNB1; CCNB2; PLK1; CDKN2D
GO:0010639 negative regulation of organelle organization 8.36 8.00e-11 1.17e-08 15/193 CDC20; NEK2; H1FX; MAD2L1; CCNB1; PTTG1; NPM1; HIST1H1A; HIST1H1C; HIST1H1E; HIST1H1D; HIST1H1B; FBXO5; PLK1; CDT1
GO:0007051 spindle organization 8.27 3.97e-06 1.62e-04 8/104 CDC20; NUF2; ASPM; NEK2; SPC25; CCNB1; FBXO5; PLK1
GO:0033044 regulation of chromosome organization 8.04 2.87e-11 8.81e-09 16/214 CDC20; NEK2; H1FX; MAD2L1; CCNB1; PTTG1; HIST1H1A; HIST1H1C; HIST1H1E; HIST1H1D; HIST1H1B; FBXO5; CDCA5; PLK1; CTCF; CDT1
GO:0050000 chromosome localization 7.97 1.48e-03 3.28e-02 4/54 NUF2; CCNB1; CDCA5; CDT1
GO:0051052 regulation of DNA metabolic process 7.71 1.13e-11 8.30e-09 17/237 NUCKS1; NEK2; MSH6; H1FX; NPM1; HIST1H1A; HIST1H1C; HIST1H1E; HIST1H1D; HIST1H1B; FBXO5; ESCO2; H2AFX; UNG; BRCA2; CDT1; KPNA2
GO:0021700 developmental maturation 7.68 4.31e-04 1.17e-02 5/70 CDC20; CCNB1; FBXO5; CD63; BRCA2
GO:1902850 microtubule cytoskeleton organization involved in mitosis 7.59 1.17e-04 3.73e-03 6/85 CDC20; NUF2; NEK2; SPC25; CCNB1; PLK1
GO:0071824 protein-DNA complex subunit organization 7.39 1.48e-07 9.23e-06 11/160 H1FX; NPM1; HIST1H1A; HIST1H1C; HIST1H1E; HIST1H1D; HIST1H1B; H2AFX; UBC; CTCF; CDT1
GO:0044839 cell cycle G2/M phase transition 7.39 2.37e-06 1.02e-04 9/131 NEK2; DTL; MSH6; CCNB1; HMMR; NPM1; FBXO5; CCNB2; PLK1
GO:0051302 regulation of cell division 7.29 2.06e-03 4.16e-02 4/59 ASPM; KIF20B; BRCA2; PLK1
GO:0006260 DNA replication 7.26 1.79e-07 1.01e-05 11/163 NUCKS1; DTL; RRM2; MSH6; SLBP; FBXO5; ESCO2; FAM111A; BRCA2; GINS2; CDT1
GO:0031023 microtubule organizing center organization 7.17 5.94e-04 1.50e-02 5/75 NEK2; NPM1; XRCC2; BRCA2; PLK1
GO:0007059 chromosome segregation 6.85 2.16e-08 1.76e-06 13/204 CDC20; NUF2; NEK2; SPC25; MAD2L1; CCNB1; PTTG1; FBXO5; ESCO2; CDCA5; PLK1; CTCF; CDT1
GO:0048285 organelle fission 6.78 1.57e-09 1.64e-07 15/238 CDC20; NUF2; ASPM; NEK2; MAD2L1; CCNB1; PTTG1; FBXO5; CDCA5; KIF20B; BRCA2; CCNB2; PLK1; CDT1; CALR
GO:0045787 positive regulation of cell cycle 6.46 5.80e-07 2.83e-05 11/183 DTL; MAD2L1; CCNB1; NPM1; FBXO5; CDCA5; KIF20B; BRCA2; CCNB2; CDT1; CALR
GO:0000075 cell cycle checkpoint 6.14 3.58e-05 1.31e-03 8/140 CDC20; DTL; MSH6; MAD2L1; CCNB1; H2AFX; PLK1; CDT1
GO:0006302 double-strand break repair 5.88 1.53e-04 4.69e-03 7/128 NUCKS1; XRCC2; ESCO2; CDCA5; H2AFX; BRCA2; GINS2
GO:1901987 regulation of cell cycle phase transition 5.87 1.36e-07 9.23e-06 13/238 CDC20; NEK2; DTL; MSH6; MAD2L1; CCNB1; HMMR; NPM1; FBXO5; CDCA5; PLK1; CDT1; CDKN2D
GO:0022412 cellular process involved in reproduction in multicellular organism 5.78 1.58e-03 3.40e-02 5/93 ASPM; CCNB1; FBXO5; BRCA2; PLK1
GO:0045930 negative regulation of mitotic cell cycle 5.66 6.46e-05 2.15e-03 8/152 CDC20; MSH6; MAD2L1; CCNB1; PTTG1; FBXO5; PLK1; CDT1
GO:0016458 gene silencing 5.61 6.11e-04 1.50e-02 6/115 H1FX; HIST1H1A; HIST1H1C; HIST1H1E; HIST1H1D; HIST1H1B
GO:0008213 protein alkylation 5.60 1.82e-03 3.81e-02 5/96 HIST1H1C; HIST1H1E; HIST1H1D; HIST1H1B; CTCF
GO:0007568 aging 5.16 9.50e-04 2.25e-02 6/125 MSH6; NPM1; FBXO5; H2AFX; BRCA2; CALR
GO:0009314 response to radiation 5.07 5.11e-05 1.78e-03 9/191 NUCKS1; DTL; MSH6; NPM1; XRCC2; HSPA5; H2AFX; BRCA2; CDKN2D
GO:0040029 regulation of gene expression, epigenetic 5.02 4.09e-04 1.15e-02 7/150 H1FX; HIST1H1A; HIST1H1C; HIST1H1E; HIST1H1D; HIST1H1B; CTCF
GO:0044772 mitotic cell cycle phase transition 4.95 3.38e-07 1.77e-05 14/304 CDC20; NEK2; DTL; RRM2; MSH6; MAD2L1; CCNB1; HMMR; FBXO5; CDCA5; CCNB2; PLK1; CDT1; CDKN2D
GO:0010498 proteasomal protein catabolic process 3.65 6.14e-04 1.50e-02 9/265 CDC20; MAD2L1; CCNB1; PTTG1; FBXO5; HSPA5; HSP90B1; UBC; PLK1
Factor 16 : 26 significant GO terms
GeneSet description enrichRatio pValue FDR GeneRatio geneSymbols
GO:0070972 protein localization to endoplasmic reticulum 11.90 0.00e+00 0.00e+00 25/121 RPS7; RPL15; RPSA; RPL9; RPL34; RPS23; RPS14; RPL10A; INSIG1; RPL10; RPS20; RPL7A; RPL27A; RPL41; RPS29; RPS27L; RPLP1; RPS2; RPL36; RPL18A; UBA52; RPS19; RPL18; RPL28; RPL3
GO:1990868 response to chemokine 11.50 3.36e-04 1.84e-02 4/20 CXCR4; CXCL10; CCL3; CCR7
GO:0006413 translational initiation 9.33 0.00e+00 0.00e+00 26/160 RPS7; RPL15; RPSA; RPL9; RPL34; RPS23; RPS14; RPL10A; RPL10; RPS20; RPL7A; RPL27A; RPL41; RPS29; RPS27L; RPLP1; RPS2; EIF1; RPL36; RPL18A; UBA52; RPS19; RPL18; RPL28; RPL3; ATF4
GO:0006959 humoral immune response 7.98 3.52e-04 1.84e-02 5/36 CXCL10; GAPDH; IFNG; CCR7; RPS19
GO:0090150 establishment of protein localization to membrane 7.88 0.00e+00 0.00e+00 28/204 RPS7; RPL15; RPSA; RPL9; RPL34; RPS23; RPS14; RPL10A; RPL10; RPS20; RPL7A; RPL27A; RPL41; GZMB; RPS29; RPS27L; RPLP1; RPS2; PMAIP1; RPL36; RPL18A; UBA52; RPS19; BBC3; RPL18; BAX; RPL28; RPL3
GO:0002181 cytoplasmic translation 7.76 4.41e-07 5.38e-05 10/74 RPL15; RPL9; RPS23; RPL10A; RPL41; RPS29; RPLP1; RPL36; RPL18A; RPL18
GO:0043270 positive regulation of ion transport 6.93 5.58e-05 4.55e-03 7/58 CXCL10; TMSB4X; TRIAP1; LGALS3; CCL3; BAX; ATF4
GO:0090559 regulation of membrane permeability 6.38 1.01e-03 3.50e-02 5/45 BLOC1S2; GZMB; PMAIP1; BBC3; BAX
GO:0060326 cell chemotaxis 6.05 4.40e-05 4.03e-03 8/76 RAB13; CXCR4; CXCL10; TMSB4X; LGALS3; CCL3; CCR7; RPS19
GO:0008637 apoptotic mitochondrial changes 5.91 1.56e-04 1.15e-02 7/68 GPX1; BLOC1S2; TRIAP1; GZMB; PMAIP1; BBC3; BAX
GO:0006401 RNA catabolic process 5.90 3.99e-14 7.30e-12 26/253 RPS7; RPL15; RPSA; RPL9; RPL34; RPS23; RPS14; RPL10A; RPL10; RPS20; RPL7A; RPL27A; VIM; RPL41; RPS29; RPS27L; RPLP1; ISG20; RPS2; RPL36; RPL18A; UBA52; RPS19; RPL18; RPL28; RPL3
GO:0071887 leukocyte apoptotic process 5.86 1.49e-03 4.58e-02 5/49 TNFRSF4; IL2RA; LGALS3; CCR7; BAX
GO:0097191 extrinsic apoptotic signaling pathway 5.44 3.36e-05 3.52e-03 9/95 TNFRSF4; GPX1; NGFRAP1; BLOC1S2; IFNG; LGALS3; PMAIP1; CD70; BAX
GO:0006605 protein targeting 5.41 3.33e-12 4.88e-10 24/255 RPS7; RPL15; RPSA; RPL9; RPL34; RPS23; RPS14; RPL10A; RPL10; RPS20; RPL7A; RPL27A; RPL41; RPS29; RPS27L; RPLP1; RPS2; RPL36; RPL18A; UBA52; RPS19; RPL18; RPL28; RPL3
GO:0042770 signal transduction in response to DNA damage 5.03 4.33e-04 1.87e-02 7/80 GADD45A; MDM2; TRIAP1; RPS27L; PMAIP1; PCNA; BAX
GO:0010959 regulation of metal ion transport 4.47 8.84e-04 3.41e-02 7/90 CXCL10; SARAF; LGALS3; B2M; CCL3; BAX; ATF4
GO:0048872 homeostasis of number of cells 3.83 1.05e-03 3.50e-02 8/120 TNFRSF4; RPS14; IL2RA; B2M; CCR7; PMAIP1; RPS19; BAX
GO:0098542 defense response to other organism 3.78 2.71e-04 1.81e-02 10/152 CXCL10; PLAC8; TRIM22; IL2RA; GAPDH; IFNG; ISG20; PMAIP1; RPS19; APOBEC3H
GO:2000147 positive regulation of cell motility 3.73 3.01e-04 1.84e-02 10/154 TNFRSF18; RHOC; CXCL10; TMSB4X; PHPT1; IFNG; MDM2; LGALS3; CCL3; CCR7
GO:0072331 signal transduction by p53 class mediator 3.59 1.60e-03 4.58e-02 8/128 GADD45A; RPS7; MDM2; TRIAP1; RPS27L; PMAIP1; PCNA; BAX
GO:0097193 intrinsic apoptotic signaling pathway 3.57 4.31e-04 1.87e-02 10/161 RPS7; GPX1; DDIT3; MDM2; TRIAP1; RPS27L; PMAIP1; BBC3; BAX; ATF4
GO:0009615 response to virus 3.49 9.87e-04 3.50e-02 9/148 CXCR4; CXCL10; TRIM22; CFL1; IL2RA; IFNG; ISG20; PMAIP1; APOBEC3H
GO:2001233 regulation of apoptotic signaling pathway 3.32 4.03e-04 1.87e-02 11/190 TNFRSF4; RPS7; GPX1; DDIT3; MDM2; TRIAP1; GZMB; LGALS3; PMAIP1; BBC3; BAX
GO:0009636 response to toxic substance 3.32 7.61e-04 3.10e-02 10/173 GPX1; HNRNPA1; MDM2; ALOX5AP; CCL3; PCNA; UBA52; BAX; ATF4; MT-ND4
GO:0052547 regulation of peptidase activity 3.29 1.50e-03 4.58e-02 9/157 GPX1; NGFRAP1; GAPDH; MDM2; TRIAP1; RPS27L; PMAIP1; BBC3; BAX
GO:0009314 response to radiation 3.01 1.63e-03 4.58e-02 10/191 GADD45A; XPC; GPX1; CXCL10; DDB2; MDM2; TRIAP1; PCNA; BAX; ATF4
Factor 17 : 36 significant GO terms
GeneSet description enrichRatio pValue FDR GeneRatio geneSymbols
GO:0070972 protein localization to endoplasmic reticulum 14.90 0.00e+00 0.00e+00 57/121 RPL11; RPS8; RPL5; RPS27; RPS7; RPS27A; RPL31; RPL32; RPL15; RPSA; RPL29; RPL9; RPL34; RPS3A; RPL37; RPS14; RPS18; RPL10A; RPS12; SEC61G; INSIG1; RPS4X; RPL39; RPL7; RPL30; RPS6; RPL12; RPL7A; RPL27A; RPS13; RPS3; RPS25; RPS24; RPL41; RPL6; RPLP0; RPL21; RPS29; RPL4; RPLP1; RPS17; RPS2; RPL13; RPL26; RPL23; RPL19; RPS15; RPS28; RPL18A; RPS16; RPS19; RPL18; RPL13A; RPS9; RPL28; RPS5; RPL3
GO:0046939 nucleotide phosphorylation 11.30 7.86e-13 6.40e-11 15/42 ENO1; PGM1; GUK1; PGK1; LDHA; PFKP; DDIT4; PGAM1; GAPDH; TPI1; ENO2; PKM; ALDOA; ALDOC; GPI
GO:0006413 translational initiation 10.90 0.00e+00 0.00e+00 55/160 RPL11; RPS8; RPL5; RPS27; RPS7; RPS27A; RPL31; RPL32; RPL15; RPSA; RPL29; RPL9; RPL34; RPS3A; RPL37; RPS14; RPS18; RPL10A; RPS12; RPS4X; RPL39; RPL7; RPL30; RPS6; RPL12; RPL7A; RPL27A; RPS13; RPS3; RPS25; RPS24; RPL41; RPL6; RPLP0; RPL21; RPS29; RPL4; RPLP1; RPS17; RPS2; RPL13; RPL26; RPL23; RPL19; RPS15; RPS28; RPL18A; RPS16; RPS19; RPL18; RPL13A; RPS9; RPL28; RPS5; RPL3
GO:0006090 pyruvate metabolic process 10.30 6.53e-13 5.98e-11 16/49 ENO1; PGM1; VDAC1; PGK1; LDHA; PFKP; DDIT4; PGAM1; GAPDH; TPI1; ENO2; PKM; ALDOA; ALDOC; SLC16A3; GPI
GO:0009132 nucleoside diphosphate metabolic process 10.30 6.53e-13 5.98e-11 16/49 ENO1; AK2; PGM1; GUK1; PGK1; LDHA; PFKP; DDIT4; PGAM1; GAPDH; TPI1; ENO2; PKM; ALDOA; ALDOC; GPI
GO:0090150 establishment of protein localization to membrane 8.83 0.00e+00 0.00e+00 57/204 RPL11; RPS8; RPL5; RPS27; RPS7; RPS27A; RPL31; RPL32; RPL15; RPSA; RPL29; RPL9; RPL34; RPS3A; RPL37; RPS14; RPS18; RPL10A; RPS12; RPS4X; RPL39; RPL7; RPL30; RPS6; RPL12; RPL7A; RPL27A; RPS13; RPS3; RPS25; RPS24; RPL41; RPL6; RPLP0; RPL21; GZMB; RPS29; RPL4; RPLP1; RPS17; RPS2; RPL13; RPL26; RPL23; RPL19; RPS15; RPS28; RPL18A; RPS16; RPS19; RPL18; RPL13A; RPS9; RPL28; RPS5; RPL3; ITGB2
GO:0002181 cytoplasmic translation 8.54 4.23e-14 5.17e-12 20/74 RPL11; RPL31; RPL32; RPL15; RPL29; RPL9; RPL10A; RPL39; RPL30; RPL41; RPL6; RPLP0; RPS29; RPLP1; RPL26; RPL19; RPS28; RPL18A; RPL18; RPL13A
GO:0016052 carbohydrate catabolic process 7.76 1.36e-09 7.13e-08 14/57 ENO1; PGM1; PGK1; LDHA; PFKP; DDIT4; PGAM1; GAPDH; TPI1; ENO2; PKM; ALDOA; ALDOC; GPI
GO:0006605 protein targeting 7.31 0.00e+00 0.00e+00 59/255 RPL11; ATPIF1; RPS8; RPL5; RPS27; RPS7; RPS27A; RPL31; RPL32; RPL15; RPSA; RPL29; RPL9; RPL34; RPS3A; RPL37; RPS14; RPS18; RPL10A; RPS12; SEC61G; RPS4X; RPL39; BNIP3L; RPL7; RPL30; RPS6; RPL12; RPL7A; RPL27A; RPS13; RPS3; RPS25; RPS24; RPL41; RPL6; RPLP0; RPL21; RPS29; RPL4; RPLP1; RPS17; RPS2; RPL13; RPL26; RPL23; RPL19; RPS15; RPS28; RPL18A; RPS16; RPS19; RPL18; RPL13A; RPS9; RPL28; RPS5; RPL3; ITGB2
GO:0006401 RNA catabolic process 7.24 0.00e+00 0.00e+00 58/253 RPL11; RPS8; RPL5; RPS27; RPS7; ZFP36L2; RPS27A; RPL31; RPL32; RPL15; RPSA; RPL29; RPL9; RPL34; RPS3A; RPL37; RPS14; RPS18; RPL10A; RPS12; RPS4X; RPL39; RPL7; RPL30; RPS6; RPL12; RPL7A; RPL27A; RPS13; RPS3; RPS25; VIM; RPS24; RPL41; RPL6; RPLP0; RPL21; RPS29; RPL4; RPLP1; RPS17; RPS2; RPL13; RPL26; RPL23; RPL19; DDX5; RPS15; RPS28; RPL18A; RPS16; RPS19; RPL18; RPL13A; RPS9; RPL28; RPS5; RPL3
GO:0072524 pyridine-containing compound metabolic process 6.60 1.32e-08 5.82e-07 14/67 ENO1; PGM1; PGK1; LDHA; PFKP; DDIT4; PGAM1; GAPDH; TPI1; ENO2; PKM; ALDOA; ALDOC; GPI
GO:0046434 organophosphate catabolic process 5.82 7.22e-08 2.78e-06 14/76 ENO1; PGM1; PGK1; LDHA; PFKP; DDIT4; PGAM1; GAPDH; TPI1; ENO2; PKM; ALDOA; ALDOC; GPI
GO:0034404 nucleobase-containing small molecule biosynthetic process 5.74 9.70e-09 4.74e-07 16/88 ENO1; PGM1; GUK1; PGK1; LDHA; PFKP; DDIT4; PGAM1; GAPDH; TPI1; ENO2; PKM; ALDOA; ALDOC; TK1; GPI
GO:0016053 organic acid biosynthetic process 4.81 1.25e-09 7.05e-08 21/138 ENO1; PGM1; INSIG2; INSIG1; PGK1; LDHA; FADS2; FADS1; PFKP; DDIT4; PGAM1; SCD; GAPDH; TPI1; ENO2; BCAT1; PKM; ALDOA; ALDOC; GPI; MIF
GO:0046390 ribose phosphate biosynthetic process 4.65 1.43e-08 5.82e-07 19/129 ENO1; AK2; PGM1; GUK1; PAICS; TMSB4X; PGK1; LDHA; PFKP; DDIT4; PGAM1; SCD; GAPDH; TPI1; ENO2; PKM; ALDOA; ALDOC; GPI
GO:0072522 purine-containing compound biosynthetic process 4.65 1.43e-08 5.82e-07 19/129 ENO1; AK2; PGM1; GUK1; PAICS; TMSB4X; PGK1; LDHA; PFKP; DDIT4; PGAM1; SCD; GAPDH; TPI1; ENO2; PKM; ALDOA; ALDOC; GPI
GO:0005996 monosaccharide metabolic process 4.56 1.65e-06 5.25e-05 14/97 ENO1; PGM1; PGK1; PFKP; PGAM1; GAPDH; TPI1; ENO2; SLC2A3; PKM; MPI; ALDOA; ALDOC; GPI
GO:0016051 carbohydrate biosynthetic process 4.45 6.67e-05 1.61e-03 10/71 ENO1; PGM1; PGK1; PGAM1; GAPDH; TPI1; ENO2; ALDOA; ALDOC; GPI
GO:0009123 nucleoside monophosphate metabolic process 4.40 1.40e-11 1.03e-09 28/201 ENO1; ATPIF1; AK2; NDUFS5; PGM1; GUK1; NDUFB4; PAICS; TMSB4X; PGK1; LDHA; PFKP; DDIT4; PGAM1; NDUFB8; GAPDH; TPI1; ENO2; PKM; ALDOA; ALDOC; TK1; GPI; MT-ND1; MT-ND2; MT-CO3; MT-ND4; MT-ND5
GO:0009141 nucleoside triphosphate metabolic process 4.30 1.41e-10 9.36e-09 26/191 ENO1; ATPIF1; AK2; NDUFS5; PGM1; GUK1; NDUFB4; TMSB4X; PGK1; LDHA; PFKP; DDIT4; PGAM1; NDUFB8; GAPDH; TPI1; ENO2; PKM; ALDOA; ALDOC; GPI; MT-ND1; MT-ND2; MT-CO3; MT-ND4; MT-ND5
GO:1901293 nucleoside phosphate biosynthetic process 3.88 1.37e-07 5.02e-06 20/163 ENO1; AK2; PGM1; GUK1; PAICS; TMSB4X; PGK1; LDHA; PFKP; DDIT4; PGAM1; SCD; GAPDH; TPI1; ENO2; PKM; ALDOA; ALDOC; TK1; GPI
GO:0051188 cofactor biosynthetic process 3.83 3.15e-06 9.63e-05 16/132 ENO1; ATPIF1; PGM1; PGK1; LDHA; PFKP; DDIT4; PGAM1; SCD; GAPDH; TPI1; ENO2; PKM; ALDOA; ALDOC; GPI
GO:0010257 NADH dehydrogenase complex assembly 3.81 2.16e-03 4.40e-02 7/58 NDUFS5; NDUFB4; NDUFB8; MT-ND1; MT-ND2; MT-ND4; MT-ND5
GO:0070482 response to oxygen levels 3.64 6.25e-06 1.76e-04 16/139 ENO1; EGLN1; RPS27A; FAM162A; HILPDA; PGK1; BNIP3L; LDHA; DDIT4; BNIP3; ERO1A; PKM; TCEB2; P4HB; MT-ND4; MT-ND5
GO:0009259 ribonucleotide metabolic process 3.55 1.17e-09 7.05e-08 29/258 ENO1; ATPIF1; AK2; NDUFS5; PGM1; GUK1; NDUFB4; PAICS; HMGCS1; TMSB4X; PGK1; LDHA; PFKP; DDIT4; PGAM1; SCD; NDUFB8; GAPDH; TPI1; ENO2; PKM; ALDOA; ALDOC; GPI; MT-ND1; MT-ND2; MT-CO3; MT-ND4; MT-ND5
GO:0008202 steroid metabolic process 3.51 4.92e-04 1.09e-02 10/90 FDPS; INSIG2; HMGCS1; ACAT2; INSIG1; EBP; FDFT1; SQLE; DHCR7; SCD
GO:0006732 coenzyme metabolic process 3.46 6.13e-06 1.76e-04 17/155 ENO1; PGM1; HMGCS1; PGK1; LDHA; PFKP; DDIT4; PGAM1; SCD; GAPDH; TPI1; ENO2; SLC2A3; PKM; ALDOA; ALDOC; GPI
GO:0016072 rRNA metabolic process 3.41 1.10e-06 3.66e-05 20/185 RPL11; RPS8; RPL5; RPS27; RPS7; RPSA; RPS14; RPL10A; RPL7; RPS6; RPL7A; RPS24; RPS17; RPS2; RPL26; RPS15; RPS28; RPS16; RPS19; RPS9
GO:0062012 regulation of small molecule metabolic process 3.40 5.20e-05 1.31e-03 14/130 ENO1; ATPIF1; FDPS; INSIG2; HMGCS1; INSIG1; TMSB4X; FDFT1; SQLE; DHCR7; DDIT4; PGAM1; SCD; OAZ1
GO:0044282 small molecule catabolic process 3.28 2.33e-05 6.11e-04 16/154 ENO1; PGM1; ADTRP; ACAT2; PGK1; PFKP; PGAM1; GAPDH; TPI1; ENO2; BCAT1; PKM; ALDOA; BCKDK; ALDOC; GPI
GO:1901615 organic hydroxy compound metabolic process 3.25 8.57e-05 1.96e-03 14/136 FDPS; INSIG2; HMGCS1; ACAT2; INSIG1; EBP; FDFT1; SQLE; LDHA; DHCR7; SCD; TPI1; DDT; ITGB2
GO:0006091 generation of precursor metabolites and energy 3.09 5.30e-07 1.85e-05 24/245 ENO1; ATPIF1; NDUFS5; PGM1; NDUFB4; PGK1; LDHA; PFKP; DDIT4; PGAM1; NDUFB8; BNIP3; GAPDH; TPI1; ENO2; PKM; ALDOA; ALDOC; GPI; MT-ND1; MT-ND2; MT-CO3; MT-ND4; MT-ND5
GO:0046677 response to antibiotic 3.03 5.33e-04 1.15e-02 12/125 TXNIP; EEF1B2; ANKZF1; TXN; LDHA; GSTP1; RPS3; BNIP3; VKORC1; RPL23; MT-ND4; MT-ND5
GO:0034470 ncRNA processing 2.60 6.79e-05 1.61e-03 20/243 RPL11; RPS8; RPL5; RPS27; RPS7; RPSA; RPS14; RPL10A; RPL7; RPS6; RPL7A; RPS24; RPS17; RPS2; RPL26; RPS15; RPS28; RPS16; RPS19; RPS9
GO:0071826 ribonucleoprotein complex subunit organization 2.51 8.49e-04 1.78e-02 15/189 RPL11; RPL5; RPS27; RPSA; RPS14; HSP90AB1; RPL12; RPL6; RPLP0; RPS15; RPS28; RPS19; RPL13A; RPS5; RPL3
GO:0022613 ribonucleoprotein complex biogenesis 2.49 6.84e-06 1.86e-04 27/342 RPL11; RPS8; RPL5; RPS27; RPS7; RPSA; RPS14; RPL10A; HSP90AB1; RPL7; RPS6; RPL12; RPL7A; RPS24; RPL6; RPLP0; RPS17; RPS2; RPL26; RPS15; RPS28; RPS16; RPS19; RPL13A; RPS9; RPS5; RPL3
Factor 18 : 51 significant GO terms
GeneSet description enrichRatio pValue FDR GeneRatio geneSymbols
GO:1990868 response to chemokine 15.40 1.59e-09 2.33e-07 9/20 XCL2; XCL1; CXCR4; CXCL10; CXCR3; CCL1; CCL3; CCL3L3; CCR7
GO:0034341 response to interferon-gamma 8.84 9.99e-16 7.32e-13 22/85 XCL2; XCL1; STAT1; IRF1; IRF4; HLA-F; HLA-E; HLA-DRA; HLA-DRB5; HLA-DRB1; HLA-DQA1; HLA-DQB1; HLA-DPA1; HLA-DPB1; IFITM2; EVL; B2M; LGALS9; CCL1; CCL3; CCL3L3; ACTG1
GO:0050920 regulation of chemotaxis 8.54 3.71e-10 6.81e-08 14/56 XCL2; XCL1; CXCR4; CXCL10; CD74; GPSM3; CORO1B; GSTP1; IL16; LGALS9; CCL1; CCL3; CCR7; RAC2
GO:0032613 interleukin-10 production 8.54 9.76e-04 2.13e-02 4/16 XCL1; TIGIT; IRF4; LGALS9
GO:0060326 cell chemotaxis 7.64 2.97e-11 7.26e-09 17/76 XCL2; XCL1; CXCR4; CXCL10; ITGA1; CD74; GPSM3; CXCR3; CORO1B; GSTP1; IL16; LGALS9; CCL1; CCL3; CCL3L3; CCR7; RAC2
GO:0032615 interleukin-12 production 7.19 1.94e-03 3.31e-02 4/19 TIGIT; IRF1; LGALS9; CCR7
GO:0033627 cell adhesion mediated by integrin 7.19 1.94e-03 3.31e-02 4/19 CYP1B1; ITGB1; ITGB7; TESC
GO:0035456 response to interferon-beta 7.19 1.94e-03 3.31e-02 4/19 PYHIN1; STAT1; IRF1; IFITM2
GO:0070265 necrotic cell death 6.83 6.66e-04 1.63e-02 5/25 BIRC3; TMEM123; FAS; YBX3; TSPO
GO:0098742 cell-cell adhesion via plasma-membrane adhesion molecules 6.83 2.37e-03 3.78e-02 4/20 SELL; EMB; ITGB1; PECAM1
GO:0050900 leukocyte migration 6.39 4.16e-13 1.52e-10 23/123 XCL2; XCL1; SELL; GYPC; CXCR4; CXCL10; PTGER4; ITGA1; CD74; GPSM3; CXCR3; DOK2; ITGB1; ITGB7; IL16; LGALS9; CCL1; CCL3; CCL3L3; CCR7; PECAM1; SIRPG; RAC2
GO:0055123 digestive system development 6.21 3.42e-03 4.94e-02 4/22 ID2; TCF7; PRDM1; AHI1
GO:0032103 positive regulation of response to external stimulus 5.96 1.79e-08 2.19e-06 15/86 XCL2; XCL1; CXCL10; PTGER4; CD74; HLA-E; GPSM3; NFKBIA; IL16; LGALS9; CCL1; CCL3; CCL3L3; CCR7; RAC2
GO:0043062 extracellular structure organization 5.49 2.90e-05 1.18e-03 9/56 CYP1B1; CAPG; ITGA1; FSCN1; PRDX4; TIMP1; ITGB1; ITGB7; PECAM1
GO:0019882 antigen processing and presentation 5.41 2.45e-08 2.57e-06 16/101 CD8A; CD74; HLA-F; HLA-E; HLA-DRA; HLA-DRB5; HLA-DRB1; HLA-DQA1; HLA-DQB1; TAP1; HLA-DMB; HLA-DPA1; HLA-DPB1; PSME1; B2M; CCR7
GO:0007229 integrin-mediated signaling pathway 5.34 2.14e-03 3.56e-02 5/32 ITGA1; TIMP1; ITGB1; ITGB7; CD63
GO:0070371 ERK1 and ERK2 cascade 5.00 3.61e-06 2.21e-04 12/82 XCL2; XCL1; PTGER4; CD74; DUSP4; TBC1D10C; GSTP1; LGALS9; CCL1; CCL3; CCL3L3; CCR7
GO:0002576 platelet degranulation 5.00 1.10e-03 2.30e-02 6/41 TIMP1; CTSW; CD63; ACTN1; CALM1; PECAM1
GO:0032609 interferon-gamma production 4.88 3.21e-03 4.81e-02 5/35 XCL1; HLA-DPA1; HLA-DPB1; LGALS9; CCR7
GO:0019932 second-messenger-mediated signaling 4.55 9.76e-06 5.11e-04 12/90 CXCR4; ITPR1; CXCL10; PTGER4; HINT1; PRKAR1B; CXCR3; TBC1D10C; CALM1; CCL3; CCR7; PTGIR
GO:0034340 response to type I interferon 4.55 1.81e-03 3.31e-02 6/45 STAT1; IRF1; IRF4; HLA-F; HLA-E; IFITM2
GO:0034612 response to tumor necrosis factor 4.22 2.13e-05 9.18e-04 12/97 XCL2; XCL1; STAT1; TRAF1; GSTP1; BIRC3; YBX3; NFKBIA; CCL1; CCL3; CCL3L3; CD70
GO:0050866 negative regulation of cell activation 4.12 1.38e-03 2.66e-02 7/58 XCL1; ID2; TIGIT; IRF1; CD74; TBC1D10C; LGALS9
GO:0070555 response to interleukin-1 4.12 1.38e-03 2.66e-02 7/58 XCL2; XCL1; NFKBIA; LGALS9; CCL1; CCL3; CCL3L3
GO:0070661 leukocyte proliferation 4.00 1.74e-05 8.51e-04 13/111 XCL1; IRF1; CD74; HLA-E; HLA-DMB; HLA-DPA1; HLA-DPB1; GSTP1; LGALS9; IKZF3; TMIGD2; CD79A; RAC2
GO:0007159 leukocyte cell-cell adhesion 3.99 3.90e-07 2.86e-05 18/154 XCL1; SELL; TIGIT; IRF1; CD74; HLA-E; HLA-DMB; HLA-DPA1; HLA-DPB1; ITGB1; ITGB7; LGALS9; CCR7; PECAM1; SIRPG; TMIGD2; RAC2; LGALS1
GO:0001819 positive regulation of cytokine production 3.96 2.08e-07 1.69e-05 19/164 XCL1; CYP1B1; STAT1; TIGIT; PTGER4; IRF1; CD74; IRF4; HLA-E; GPSM3; HLA-DPA1; HLA-DPB1; BIRC3; B2M; LGALS9; CCL1; CCL3; CCR7; TMIGD2
GO:0072507 divalent inorganic cation homeostasis 3.94 4.58e-06 2.58e-04 15/130 CD52; XCL1; CXCR4; ITPR1; CXCL10; PTGER4; CXCR3; EPHX2; ATP2B1; CALM1; HERPUD1; CCL1; CCL3; CCR7; PTGIR
GO:0002237 response to molecule of bacterial origin 3.76 1.41e-04 4.70e-03 11/100 CXCL10; PTGER4; GSTP1; NFKBIA; B2M; LITAF; LGALS9; CCL3; CCR7; PTGIR; TSPO
GO:0050727 regulation of inflammatory response 3.72 1.54e-04 4.92e-03 11/101 XCL1; PTGER4; HLA-E; GPSM3; GSTP1; BIRC3; NFKBIA; CCL1; CCL3; CCL3L3; CCR7
GO:0007249 I-kappaB kinase/NF-kappaB signaling 3.52 6.78e-05 2.62e-03 13/126 RHOC; REL; STAT1; CD74; PRDX4; PIM2; GSTP1; BIRC3; NFKBIA; LITAF; LGALS9; CCR7; LGALS1
GO:0042110 T cell activation 3.51 1.81e-07 1.66e-05 22/214 XCL1; CD8A; TIGIT; PTGER4; IRF1; TCF7; CD74; IRF4; HLA-E; HLA-DMB; HLA-DPA1; HLA-DPB1; PRDM1; SIT1; B2M; LGALS9; CCR7; CD7; SIRPG; TMIGD2; RAC2; LGALS1
GO:0003013 circulatory system process 3.49 9.87e-04 2.13e-02 9/88 XCL2; ID2; STAT1; ITPR1; CXCL10; ITGA1; EPHX2; ATP2B1; CALM1
GO:0031589 cell-substrate adhesion 3.49 9.87e-04 2.13e-02 9/88 ITGA1; ITGB1; ITGB7; CD63; ACTN1; CCR7; PECAM1; RAC2; LGALS1
GO:0010959 regulation of metal ion transport 3.41 1.16e-03 2.36e-02 9/90 XCL1; CXCL10; CD63; TESC; CALM1; B2M; IL16; CCL3; TSPO
GO:0002694 regulation of leukocyte activation 3.27 2.18e-06 1.45e-04 20/209 XCL1; ID2; TIGIT; IRF1; CD74; IRF4; HLA-E; HLA-DMB; HLA-DPA1; HLA-DPB1; PRDM1; SIT1; TBC1D10C; LGALS9; IKZF3; CCR7; SIRPG; TMIGD2; RAC2; LGALS1
GO:0002250 adaptive immune response 3.25 8.57e-05 3.14e-03 14/147 XCL1; CD8A; IRF1; CD74; IRF4; HLA-F; HLA-E; HLA-DQB1; TAP1; PRDM1; SIT1; B2M; CD7; CD79A
GO:0009615 response to virus 3.23 9.23e-05 3.22e-03 14/148 XCL1; BATF3; CXCR4; STAT1; CXCL10; IRF1; PIM2; IFITM2; BIRC3; DDIT4; NPC2; RPS15A; LGALS9; PMAIP1
GO:0007015 actin filament organization 3.20 3.24e-04 9.90e-03 12/128 RHOC; TMSB10; CAPG; PTGER4; FSCN1; CORO1B; ITGB1; ACTN1; EVL; CCR7; VASP; RAC2
GO:0048872 homeostasis of number of cells 3.13 7.00e-04 1.65e-02 11/120 ID2; STAT1; CD74; SFXN1; SIT1; RPS24; B2M; RPS17; LGALS9; CCR7; PMAIP1
GO:0002521 leukocyte differentiation 3.04 1.98e-05 9.09e-04 18/202 BATF3; ID2; CD8A; PTGER4; IRF1; TCF7; CD74; IRF4; PRDM1; ITGB1; TESC; B2M; LGALS9; CCL3; IKZF3; CCR7; CD79A; LGALS1
GO:0002449 lymphocyte mediated immunity 3.01 2.79e-03 4.27e-02 9/102 XCL1; CD8A; CD74; HLA-F; HLA-E; HLA-DQB1; GZMB; B2M; LGALS9
GO:0051235 maintenance of location 2.97 1.83e-03 3.31e-02 10/115 XCL1; TMSB10; ITPR1; CXCL10; INSIG1; NFKBIA; CALM1; CCL3; CCR7; TSPO
GO:0031349 positive regulation of defense response 2.85 5.80e-04 1.52e-02 13/156 PYHIN1; PTGER4; IRF1; IRF4; HLA-E; GPSM3; BIRC3; NFKBIA; LGALS9; CCL1; CCL3; CCL3L3; CCR7
GO:0022407 regulation of cell-cell adhesion 2.83 6.16e-04 1.56e-02 13/157 XCL1; TIGIT; IRF1; CD74; HLA-E; HLA-DMB; HLA-DPA1; HLA-DPB1; LGALS9; CCR7; SIRPG; TMIGD2; LGALS1
GO:0030099 myeloid cell differentiation 2.81 4.01e-04 1.16e-02 14/170 BATF3; ID2; STAT1; CD74; SFXN1; IRF4; KMT2A; TESC; NFKBIA; ACTN1; B2M; LGALS9; CCL3; CCR7
GO:1903706 regulation of hemopoiesis 2.80 4.26e-04 1.16e-02 14/171 ID2; STAT1; IRF1; CD74; IRF4; PRDM1; KMT2A; TESC; NFKBIA; B2M; LGALS9; CCL3; IKZF3; LGALS1
GO:0050867 positive regulation of cell activation 2.65 2.77e-03 4.27e-02 11/142 XCL1; CD74; HLA-E; HLA-DMB; HLA-DPA1; HLA-DPB1; LGALS9; CCR7; SIRPG; TMIGD2; LGALS1
GO:0002683 negative regulation of immune system process 2.58 2.23e-03 3.63e-02 12/159 XCL1; ID2; TIGIT; PTGER4; IRF1; CD74; IRF4; HLA-E; TBC1D10C; NFKBIA; LGALS9; CCL3
GO:0002764 immune response-regulating signaling pathway 2.58 4.15e-04 1.16e-02 16/212 IRF1; IRF4; HLA-DRA; HLA-DRB5; HLA-DRB1; HLA-DQA1; HLA-DQB1; HLA-DPA1; HLA-DPB1; BIRC3; NFKBIA; CALM1; LGALS9; CCR7; ACTG1; CD79A
GO:0002697 regulation of immune effector process 2.57 3.44e-03 4.94e-02 11/146 XCL1; STAT1; CD74; IRF4; HLA-F; HLA-E; HLA-DMB; BIRC3; B2M; LGALS9; RAC2
Factor 19 : 145 significant GO terms
GeneSet description enrichRatio pValue FDR GeneRatio geneSymbols
GO:1990868 response to chemokine 13.50 5.08e-10 3.09e-08 10/20 XCL2; XCL1; CXCL10; CXCR3; HIF1A; CCL5; CCL3; CCL3L3; CCL4L2; CCR7
GO:0034113 heterotypic cell-cell adhesion 11.80 7.32e-07 1.92e-05 7/16 CD58; CD2; ITGA4; FLOT1; CD44; ITGB1; MBP
GO:0007187 G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger 10.10 5.48e-10 3.09e-08 12/32 RAMP1; CXCL10; PTGER4; HRH2; FLNA; ANXA1; PTGER2; GPR65; ADGRG5; GNA15; S1PR4; PTGIR
GO:0002507 tolerance induction 9.83 4.88e-04 4.89e-03 4/11 ICOS; HAVCR2; IL2RA; HMGB1
GO:0050918 positive chemotaxis 9.83 4.88e-04 4.89e-03 4/11 HMGB1; IL16; CCL5; CCL3
GO:0031579 membrane raft organization 9.01 7.11e-04 6.69e-03 4/12 CD2; S100A10; FLOT1; ANXA2
GO:0001773 myeloid dendritic cell activation 8.45 2.06e-04 2.69e-03 5/16 CD2; CSF2; HAVCR2; IRF4; HMGB1
GO:0007200 phospholipase C-activating G protein-coupled receptor signaling pathway 8.11 4.94e-03 2.89e-02 3/10 F2R; GPR65; GNA15
GO:0042092 type 2 immune response 8.11 4.94e-03 2.89e-02 3/10 XCL1; ANXA1; GATA3
GO:0043276 anoikis 7.37 6.60e-03 3.59e-02 3/11 MCL1; ITGB1; BCL2
GO:0050663 cytokine secretion 7.29 5.05e-11 5.28e-09 17/63 TNFRSF4; TNFRSF1B; GBP5; CD58; CD2; PTGER4; F2R; HAVCR2; LCP2; ANXA1; CRTAM; GATA3; HMGB1; CCL3; CCR7; MBP; OSM
GO:0032612 interleukin-1 production 7.28 3.07e-05 4.89e-04 7/26 GBP5; F2R; HAVCR2; ANXA1; HMGB1; CCL3; CCR7
GO:0032963 collagen metabolic process 7.11 5.01e-04 4.89e-03 5/19 RAP1A; F2R; VIM; ITGB1; HIF1A
GO:0033627 cell adhesion mediated by integrin 7.11 5.01e-04 4.89e-03 5/19 CYP1B1; DPP4; ITGB1; PTPN6; CCL5
GO:0070371 ERK1 and ERK2 cascade 6.92 7.19e-13 1.05e-10 21/82 RAP1A; XCL2; XCL1; PTGER4; F2R; HAVCR2; MFHAS1; DUSP4; AAED1; PRKCDBP; CD44; PTPN6; DUSP6; HMGB1; GPR183; CTSH; CCL5; CCL3; CCL3L3; CCL4L2; CCR7
GO:0048678 response to axon injury 6.76 6.48e-04 6.16e-03 5/20 AIF1; BCL2; LGALS1; TSPO; SOD1
GO:0032613 interleukin-10 production 6.76 2.33e-03 1.66e-02 4/16 XCL1; TIGIT; IRF4; HMGB1
GO:0007586 digestion 6.76 8.57e-03 4.45e-02 3/12 HRH2; LIMA1; TYMP
GO:0031644 regulation of neurological system process 6.76 8.57e-03 4.45e-02 3/12 F2R; CCL3; TYMP
GO:0034405 response to fluid shear stress 6.76 8.57e-03 4.45e-02 3/12 CSF2; MTSS1; KLF2
GO:0044091 membrane biogenesis 6.76 8.57e-03 4.45e-02 3/12 S100A10; FLOT1; ANXA2
GO:0001906 cell killing 6.64 1.06e-08 4.08e-07 14/57 PRDX1; XCL1; LYST; IL7R; HAVCR2; CTSC; CRTAM; PRF1; LAG3; PTPN6; IFNG; GZMB; RAB27A; CTSH
GO:0070265 necrotic cell death 6.49 2.33e-04 2.94e-03 6/25 FTH1; BIRC3; TMEM123; CYLD; TSPO; MT-CO2
GO:0014812 muscle cell migration 6.43 8.25e-04 7.56e-03 5/21 AIF1; ANXA1; CORO1B; CCL5; BCL2
GO:0060326 cell chemotaxis 6.40 1.43e-10 1.31e-08 18/76 XCL2; XCL1; LYST; CXCL10; AIF1; CXCR3; ANXA1; CORO1B; HMGB1; GPR183; IL16; CKLF; CCL5; CCL3; CCL3L3; CCL4L2; CCR7; CALR
GO:0050900 leukocyte migration 6.37 2.22e-16 8.14e-14 29/123 TNFRSF18; CD58; CD2; XCL2; XCL1; LYST; ITGA4; CXCL10; PTGER4; AIF1; CXCR3; ANXA1; FUT7; CD44; GATA3; ITGB1; PTPN6; HMGB1; GPR183; IL16; CKLF; CCL5; CCL3; CCL3L3; CCL4L2; CCR7; PECAM1; SIRPG; CALR
GO:0002437 inflammatory response to antigenic stimulus 6.36 2.96e-03 1.94e-02 4/17 IL2RA; GATA3; HMGB1; CCR7
GO:0097366 response to bronchodilator 6.36 2.96e-03 1.94e-02 4/17 RGS10; CALM1; CCR7; SOD1
GO:0050920 regulation of chemotaxis 6.27 7.52e-08 2.30e-06 13/56 XCL2; XCL1; CXCL10; AIF1; CORO1B; HMGB1; GPR183; IL16; CCL5; CCL3; CCL4L2; CCR7; CALR
GO:0055123 digestive system development 6.14 1.04e-03 9.01e-03 5/22 ID2; HRH2; AHI1; HIF1A; BCL2
GO:0006968 cellular defense response 6.01 3.69e-03 2.31e-02 4/18 TNFRSF4; LSP1; ITGB1; PRF1
GO:0032602 chemokine production 6.01 3.69e-03 2.31e-02 4/18 HAVCR2; HMGB1; HIF1A; MBP
GO:0002576 platelet degranulation 5.93 1.35e-05 2.47e-04 9/41 TAGLN2; FAM3C; TIMP1; FLNA; CTSW; CD9; CALM1; PECAM1; SOD1
GO:0032623 interleukin-2 production 5.91 1.30e-04 1.80e-03 7/32 XCL1; HAVCR2; IRF4; ANXA1; GATA3; LAG3; HDAC7
GO:0042116 macrophage activation 5.88 1.28e-03 1.05e-02 5/23 CSF2; HAVCR2; AIF1; MFHAS1; HMGB1
GO:0043062 extracellular structure organization 5.79 6.20e-07 1.68e-05 12/56 TNFRSF1B; CYP1B1; DPP4; ITGA4; FLOT1; FSCN1; TIMP1; CD44; ITGB1; SPOCK2; ANXA2; PECAM1
GO:0032615 interleukin-12 production 5.69 4.55e-03 2.74e-02 4/19 TIGIT; IFNG; HMGB1; CCR7
GO:0033619 membrane protein proteolysis 5.63 1.57e-03 1.20e-02 5/24 TNFRSF1B; SNX9; TIMP1; IFNG; CTSH
GO:2001057 reactive nitrogen species metabolic process 5.63 1.57e-03 1.20e-02 5/24 CYP1B1; AIF1; IFNG; KLF2; TSPO
GO:0032609 interferon-gamma production 5.41 2.37e-04 2.94e-03 7/35 CD2; XCL1; CD96; HAVCR2; GATA3; HMGB1; CCR7
GO:0032637 interleukin-8 production 5.41 5.52e-03 3.11e-02 4/20 CD58; CD2; F2R; ANXA1
GO:0060191 regulation of lipase activity 5.41 5.52e-03 3.11e-02 4/20 ANXA1; CCL5; GNA15; S1PR4
GO:0098742 cell-cell adhesion via plasma-membrane adhesion molecules 5.41 5.52e-03 3.11e-02 4/20 ITGB1; PECAM1; MBP; FXYD5
GO:0002449 lymphocyte mediated immunity 5.30 4.95e-10 3.09e-08 20/102 TNFRSF1B; PRDX1; XCL1; LYST; CD8A; CD96; IL7R; HAVCR2; CTSC; CRTAM; GATA3; PRF1; CD27; LAG3; PTPN6; KLRD1; HMGB1; GZMB; RAB27A; CTSH
GO:0006959 humoral immune response 5.26 2.85e-04 3.37e-03 7/36 CXCL10; GATA3; PTPN6; IFNG; GPR183; CCR7; BCL2
GO:0050866 negative regulation of cell activation 5.13 6.60e-06 1.38e-04 11/58 XCL1; ID2; TIGIT; HAVCR2; LST1; ANXA1; IL2RA; CD9; LAG3; PTPN6; HMGB1
GO:0070555 response to interleukin-1 5.13 6.60e-06 1.38e-04 11/58 GBP2; XCL2; XCL1; CD38; ANXA1; HIF1A; CCL5; CCL3; CCL3L3; CCL4L2; KLF2
GO:0008037 cell recognition 5.11 3.40e-04 3.84e-03 7/37 HAVCR2; CD5; CRTAM; PRF1; CD9; CCR7; PECAM1
GO:0045165 cell fate commitment 5.11 3.40e-04 3.84e-03 7/37 MCL1; ID2; IRF4; GATA3; ITGB1; CYLD; BCL2
GO:0097696 STAT cascade 5.07 5.15e-05 7.71e-04 9/48 TNFRSF18; CYP1B1; IL7R; F2R; CSF2; IFNG; CCL5; PECAM1; OSM
GO:0032103 positive regulation of response to external stimulus 5.03 6.47e-08 2.06e-06 16/86 GBP5; XCL2; XCL1; CXCL10; PTGER4; HAVCR2; AIF1; HMGB1; IL16; CCL5; CCL3; CCL3L3; CCL4L2; CCR7; CALR; OSM
GO:0045785 positive regulation of cell adhesion 5.01 5.16e-13 9.45e-11 28/151 TNFRSF18; S100A10; XCL1; DPP4; ITGA4; ICOS; IL7R; HAVCR2; FLOT1; AIF1; FLNA; ANXA1; NINJ1; CD44; CD5; IL2RA; GATA3; SPOCK2; CD27; PTPN6; IFNG; HMGB1; CYLD; CCL5; CCR7; SIRPG; CALR; LGALS1
GO:0071887 leukocyte apoptotic process 4.96 6.11e-05 8.78e-04 9/49 TNFRSF4; IL7R; TSC22D3; ANXA1; IL2RA; CD27; HIF1A; CCL5; CCR7
GO:0034109 homotypic cell-cell adhesion 4.83 3.23e-03 2.08e-02 5/28 FLNA; CD9; PTPN6; CCL5; LGALS1
GO:0042110 T cell activation 4.80 1.11e-16 8.14e-14 38/214 TNFRSF18; TNFRSF4; TNFRSF1B; CD2; XCL1; CD8A; CD8B; DPP4; ICOS; TIGIT; IL7R; PTGER4; HAVCR2; IRF4; AIF1; SIT1; ANXA1; FUT7; CD5; CD3D; CRTAM; IL2RA; GATA3; CD27; LAG3; PTPN6; IFNG; HMGB1; GPR183; RAB27A; CYLD; CCL5; CCR7; CD7; BCL2; SIRPG; LGALS1; SOD1
GO:0034341 response to interferon-gamma 4.77 3.52e-07 1.03e-05 15/85 GBP2; GBP5; CD58; XCL2; XCL1; IRF4; AIF1; CD44; VIM; IFNG; MT2A; CCL5; CCL3; CCL3L3; CCL4L2
GO:0034612 response to tumor necrosis factor 4.74 6.22e-08 2.06e-06 17/97 TNFRSF18; TNFRSF4; TNFRSF9; TNFRSF1B; GBP2; CD58; XCL2; XCL1; BIRC3; GATA3; CD27; CYLD; CCL5; CCL3; CCL3L3; CCL4L2; KLF2
GO:0048872 homeostasis of number of cells 4.73 1.61e-09 8.44e-08 21/120 TNFRSF4; PRDX1; ID2; IL7R; F2R; SFXN1; TSC22D3; MFHAS1; SIT1; ANXA1; IL2RA; GATA3; HMGB1; GPR183; HIF1A; RPS17; CYLD; CCR7; BCL2; KLF2; SOD1
GO:0043270 positive regulation of ion transport 4.66 4.20e-05 6.55e-04 10/58 XCL1; CXCL10; F2R; FLNA; CALM1; ANXA2; CCL5; CCL3; CCL4L2; TSPO
GO:0030101 natural killer cell activation 4.66 3.78e-03 2.33e-02 5/29 PRDX1; CD2; ID2; HAVCR2; RAB27A
GO:1903034 regulation of response to wounding 4.66 3.78e-03 2.33e-02 5/29 F2R; ANXA1; CD9; HMGB1; ANXA2
GO:0022407 regulation of cell-cell adhesion 4.65 9.11e-12 1.11e-09 27/157 XCL1; DPP4; ITGA4; ICOS; TIGIT; IL7R; HAVCR2; FLOT1; AIF1; ANXA1; CD44; CD5; IL2RA; GATA3; CD9; CD27; LAG3; PTPN6; IFNG; HMGB1; CYLD; CCL5; CCR7; MBP; SIRPG; FXYD5; LGALS1
GO:0050867 positive regulation of cell activation 4.57 2.12e-10 1.55e-08 24/142 TNFRSF4; CD2; XCL1; DPP4; ICOS; CD38; IL7R; HAVCR2; AIF1; ANXA1; CD5; IL2RA; GATA3; CD27; PTPN6; IFNG; HMGB1; GPR183; CYLD; CCL5; CCR7; BCL2; SIRPG; LGALS1
GO:0010959 regulation of metal ion transport 4.50 7.61e-07 1.92e-05 15/90 XCL1; CXCL10; F2R; FLNA; AHNAK; PTPN6; CALM1; ANXA2; IL16; CCL5; CCL3; CCL4L2; BCL2; FXYD5; TSPO
GO:0001818 negative regulation of cytokine production 4.41 4.29e-07 1.21e-05 16/98 TNFRSF4; XCL1; CD96; TIGIT; PTGER4; HAVCR2; ANXA1; GATA3; LAG3; PTPN6; HDAC7; IFNG; HMGB1; CYLD; KLF2; TSPO
GO:0002694 regulation of leukocyte activation 4.40 6.95e-14 1.70e-11 34/209 TNFRSF18; TNFRSF4; TNFRSF1B; CD2; XCL1; ID2; DPP4; ICOS; TIGIT; CD38; IL7R; HAVCR2; IRF4; LST1; AIF1; MFHAS1; SIT1; ANXA1; CD5; IL2RA; GATA3; CD27; LAG3; PTPN6; IFNG; HMGB1; GPR183; CYLD; CCL5; CCR7; BCL2; SIRPG; LGALS1; SOD1
GO:0007159 leukocyte cell-cell adhesion 4.39 2.12e-10 1.55e-08 25/154 XCL1; DPP4; ITGA4; ICOS; TIGIT; IL7R; HAVCR2; AIF1; ANXA1; CD44; CD5; IL2RA; GATA3; ITGB1; CD27; LAG3; PTPN6; IFNG; HMGB1; CYLD; CCL5; CCR7; PECAM1; SIRPG; LGALS1
GO:0048771 tissue remodeling 4.38 2.11e-03 1.52e-02 6/37 CD38; F2R; TIMP1; ANXA1; HMGB1; HIF1A
GO:0072507 divalent inorganic cation homeostasis 4.37 7.29e-09 2.97e-07 21/130 XCL1; CD38; CXCL10; PTGER4; F2R; CXCR3; PTPN6; HMGB1; PTGER2; GPR65; CALM1; ANXA2; MT2A; CCL5; CCL3; CCR7; BCL2; GNA15; S1PR4; CALR; PTGIR
GO:0007272 ensheathment of neurons 4.36 5.10e-03 2.94e-02 5/31 TNFRSF1B; CD9; MBP; TYMP; SOD1
GO:0002791 regulation of peptide secretion 4.31 4.02e-09 1.84e-07 22/138 TNFRSF4; TNFRSF1B; RAP1A; CD58; CD2; DPP4; CD38; PTGER4; F2R; HAVCR2; RAB11FIP1; ANXA1; CRTAM; GATA3; IFNG; HMGB1; HIF1A; CCL5; CCL3; CCR7; MBP; OSM
GO:0032635 interleukin-6 production 4.27 2.43e-03 1.70e-02 6/38 F2R; HAVCR2; PTPN6; HMGB1; MBP; KLF2
GO:0051702 interaction with symbiont 4.27 2.43e-03 1.70e-02 6/38 RAB9A; CALM1; ANXA2; CCL5; CCL3; CCL4L2
GO:0090130 tissue migration 4.23 8.74e-06 1.69e-04 13/83 CYP1B1; DPP4; ANXA1; CORO1B; GATA3; ITGB1; HDAC7; IFNG; HMGB1; HIF1A; CTSH; PECAM1; CALR
GO:0048017 inositol lipid-mediated signaling 4.20 1.17e-03 9.72e-03 7/45 F2R; IER3; GATA3; PTPN6; CCL5; HCST; OSM
GO:0007162 negative regulation of cell adhesion 4.18 1.00e-05 1.88e-04 13/84 XCL1; CYP1B1; TIGIT; HAVCR2; ANXA1; IL2RA; CD9; LAG3; PTPN6; HMGB1; MBP; FXYD5; LGALS1
GO:0002237 response to molecule of bacterial origin 4.05 3.04e-06 6.96e-05 15/100 TNFRSF1B; CD96; CXCL10; PTGER4; F2R; CSF2; HAVCR2; VIM; HMGB1; PTGER2; CCL5; CCL3; CCR7; PTGIR; TSPO
GO:0002250 adaptive immune response 4.04 1.35e-08 4.95e-07 22/147 TNFRSF1B; XCL1; CD8A; CD8B; IL7R; HAVCR2; IRF4; SIT1; ANXA1; CTSC; CD3D; CRTAM; GATA3; PRF1; CD27; PTPN6; IFNG; HMGB1; GPR183; RAB27A; CTSH; CD7
GO:0050727 regulation of inflammatory response 4.01 3.45e-06 7.67e-05 15/101 TNFRSF1B; GBP5; XCL1; PTGER4; MFHAS1; ANXA1; BIRC3; IL2RA; GATA3; CYLD; CCL5; CCL3; CCL3L3; CCR7; OSM
GO:0031589 cell-substrate adhesion 3.99 1.69e-05 3.01e-04 13/88 S100A10; ITGA4; CD96; FLNA; NINJ1; CD44; ITGB1; SPOCK2; CCR7; PECAM1; BCL2; CALR; LGALS1
GO:0043491 protein kinase B signaling 3.97 1.70e-04 2.30e-03 10/68 ICOS; MFHAS1; TXN; PRKCDBP; GATA3; ITGB1; CCL5; CCL3; CCR7; OSM
GO:0001819 positive regulation of cytokine production 3.96 4.43e-09 1.91e-07 24/164 GBP5; CD58; CD2; XCL1; CYP1B1; TIGIT; PTGER4; F2R; CSF2; HAVCR2; IRF4; FLOT1; ANXA1; BIRC3; CRTAM; GATA3; IFNG; HMGB1; HIF1A; CCL3; CCR7; MBP; OSM; SOD1
GO:0051047 positive regulation of secretion 3.93 1.03e-06 2.51e-05 17/117 TNFRSF4; CD58; CD2; CD38; PTGER4; F2R; HAVCR2; RAB9A; CRTAM; GATA3; IFNG; HMGB1; HIF1A; RAB27A; CCL3; MBP; OSM
GO:0019932 second-messenger-mediated signaling 3.90 2.16e-05 3.61e-04 13/90 RAMP1; CXCL10; PTGER4; CXCR3; PTGER2; GPR65; CALM1; ADGRG5; CCL3; CCL4L2; CCR7; S1PR4; PTGIR
GO:0070661 leukocyte proliferation 3.90 2.42e-06 5.71e-05 16/111 TNFRSF4; TNFRSF1B; XCL1; CD38; IL7R; HAVCR2; LST1; AIF1; ANXA1; CRTAM; IL2RA; PTPN6; HMGB1; GPR183; CCL5; BCL2
GO:0008277 regulation of G protein-coupled receptor signaling pathway 3.86 8.65e-03 4.46e-02 5/35 RAMP1; RGS3; RGS10; CALM1; CCL5
GO:2000147 positive regulation of cell motility 3.86 3.24e-08 1.13e-06 22/154 TNFRSF18; XCL2; XCL1; ITGA4; CXCL10; F2R; AIF1; FLNA; ANXA1; GATA3; SPOCK2; HDAC7; IFNG; HMGB1; HIF1A; CTSH; CCL5; CCL3; CCL4L2; CCR7; BCL2; CALR
GO:0090596 sensory organ morphogenesis 3.86 4.09e-03 2.50e-02 6/42 AHI1; GATA3; HIF1A; RPL38; BCL2; SOD1
GO:0038061 NIK/NF-kappaB signaling 3.86 9.35e-04 8.46e-03 8/56 PRDX1; HAVCR2; BIRC3; CD27; HDAC7; HMGB1; CYLD; CALR
GO:0001667 ameboidal-type cell migration 3.79 7.20e-06 1.47e-04 15/107 CYP1B1; DPP4; ITGA4; TIMP1; ANXA1; CORO1B; GATA3; ITGB1; HDAC7; IFNG; HMGB1; HIF1A; CTSH; PECAM1; CALR
GO:0002285 lymphocyte activation involved in immune response 3.70 3.09e-04 3.59e-03 10/73 PTGER4; HAVCR2; IRF4; ANXA1; GATA3; IFNG; HMGB1; GPR183; RAB27A; LGALS1
GO:0002521 leukocyte differentiation 3.61 3.41e-09 1.67e-07 27/202 TNFRSF18; CD2; ID2; CD8A; ITGA4; IL7R; PTGER4; CSF2; IRF4; ANXA1; FUT7; CD3D; IL2RA; GATA3; ITGB1; CD27; PTPN6; IFNG; HMGB1; GPR183; ANXA2; CYLD; CCL3; CCR7; BCL2; LGALS1; SOD1
GO:0097305 response to alcohol 3.60 3.86e-04 4.29e-03 10/75 PTGER4; GATA3; CD27; PTGER2; CALM1; CCL3; CCR7; KLF2; GRAMD1A; SOD1
GO:0071706 tumor necrosis factor superfamily cytokine production 3.57 3.09e-03 2.00e-02 7/53 CD2; HAVCR2; PTPN6; IFNG; HMGB1; CCL3; TSPO
GO:0006898 receptor-mediated endocytosis 3.56 4.31e-04 4.57e-03 10/76 ITGA4; RAMP1; FLOT1; AHI1; SNX9; CD5; ITGB1; CD9; ANXA2; CALR
GO:0032102 negative regulation of response to external stimulus 3.56 4.31e-04 4.57e-03 10/76 TNFRSF1B; PTGER4; HAVCR2; AIF1; MFHAS1; CORO1B; IL2RA; GATA3; CD9; ANXA2
GO:0051271 negative regulation of cellular component movement 3.56 4.31e-04 4.57e-03 10/76 CYP1B1; PTGER4; AIF1; TIMP1; CORO1B; GATA3; CD9; HMGB1; BCL2; CALR
GO:1901654 response to ketone 3.54 1.66e-03 1.24e-02 8/61 CD38; PTGER4; PTGER2; CALM1; CCR7; CALR; KLF2; TSPO
GO:0034764 positive regulation of transmembrane transport 3.53 6.46e-03 3.56e-02 6/46 RAP1A; XCL1; CXCL10; F2R; FLNA; CALM1
GO:0034330 cell junction organization 3.51 4.79e-04 4.89e-03 10/77 RAP1A; S100A10; F2R; FLOT1; FSCN1; FLNA; CD9; HDAC7; PRKCH; BCL2
GO:1901342 regulation of vasculature development 3.51 4.79e-04 4.89e-03 10/77 RAP1A; CYP1B1; CXCL10; ANXA1; ITGB1; HDAC7; HMGB1; HIF1A; CTSH; KLF2
GO:0072511 divalent inorganic cation transport 3.46 2.18e-05 3.61e-04 15/117 XCL1; RAMP1; CXCL10; F2R; AHNAK; PTPN6; CALM1; ANXA2; IL16; CCL5; CCL3; CCL4L2; CCR7; BCL2; TSPO
GO:0035821 modification of morphology or physiology of other organism 3.43 2.04e-03 1.48e-02 8/63 RAB9A; PRF1; IFNG; CALM1; ANXA2; CCL5; CCL3; CCL4L2
GO:0001505 regulation of neurotransmitter levels 3.43 1.10e-03 9.25e-03 9/71 RAP1A; CYP1B1; FLOT1; AIF1; SLC38A1; IFNG; CALM1; KLF2; TSPO
GO:0001655 urogenital system development 3.33 2.50e-03 1.70e-02 8/65 ID2; AHI1; MTSS1; ANXA1; GATA3; CTSH; PECAM1; BCL2
GO:0042063 gliogenesis 3.24 1.63e-03 1.23e-02 9/75 ID2; ANXA1; VIM; CD9; GPR183; PRKCH; CCL3; TSPO; SOD1
GO:0072593 reactive oxygen species metabolic process 3.24 2.80e-04 3.37e-03 12/100 PRDX1; CYP1B1; AIF1; STK17A; IFNG; HIF1A; RAB27A; BCL2; KLF2; TSPO; SOD1; MT-CO2
GO:0071216 cellular response to biotic stimulus 3.20 1.79e-03 1.33e-02 9/76 TNFRSF1B; CXCL10; CSF2; HAVCR2; VIM; HMGB1; CCL5; CCL3; TSPO
GO:0009914 hormone transport 3.18 1.06e-03 9.01e-03 10/85 RAP1A; DPP4; CD38; RAB11FIP1; ANXA1; GATA3; IFNG; HIF1A; CCL5; OSM
GO:0001525 angiogenesis 3.15 1.18e-04 1.66e-03 14/120 CYP1B1; RAMP1; CXCL10; CXCR3; ANXA1; ITGB1; HDAC7; HMGB1; HIF1A; ANXA2; CTSH; PECAM1; KLF2; TYMP
GO:0002064 epithelial cell development 3.15 6.23e-03 3.46e-02 7/60 RAP1A; HRH2; FLNA; VIM; HIF1A; PECAM1; SOD1
GO:0002697 regulation of immune effector process 3.15 2.21e-05 3.61e-04 17/146 TNFRSF4; TNFRSF1B; RAP1A; XCL1; CD96; IL7R; HAVCR2; IRF4; ANXA1; BIRC3; CRTAM; IL2RA; GATA3; LAG3; PTPN6; IFNG; HMGB1
GO:0043087 regulation of GTPase activity 3.13 7.65e-06 1.52e-04 19/164 RAP1A; S100A10; XCL2; XCL1; RASGRP3; F2R; SNX9; TAGAP; RGS3; ITGB1; RGS10; GPR65; RIN3; CCL5; CCL3; CCL3L3; CCL4L2; CCR7; SOD1
GO:0055076 transition metal ion homeostasis 3.10 6.82e-03 3.68e-02 7/61 ATOX1; SFXN1; FTH1; HIF1A; MT2A; FTL; SOD1
GO:0003012 muscle system process 3.07 1.39e-03 1.10e-02 10/88 TNFRSF1B; LMNA; CD38; F2R; AIF1; FLNA; VIM; MYL6; CALM1; SOD1
GO:0003013 circulatory system process 3.07 1.39e-03 1.10e-02 10/88 XCL2; ID2; CD38; CXCL10; F2R; HRH2; FLNA; PTGER2; CALM1; SOD1
GO:0002683 negative regulation of immune system process 3.06 1.86e-05 3.24e-04 18/159 TNFRSF4; XCL1; ID2; CD96; TIGIT; IL7R; PTGER4; HAVCR2; IRF4; LST1; TSC22D3; MFHAS1; ANXA1; IL2RA; LAG3; PTPN6; HMGB1; CCL3
GO:0051235 maintenance of location 3.06 2.85e-04 3.37e-03 13/115 XCL1; CXCL10; F2R; FLNA; TXN; FTH1; PTPN6; CALM1; CCL3; CCR7; CALR; FTL; TSPO
GO:0040013 negative regulation of locomotion 3.04 2.57e-03 1.71e-02 9/80 CYP1B1; PTGER4; AIF1; TIMP1; CORO1B; GATA3; HMGB1; BCL2; CALR
GO:0050817 coagulation 3.00 9.72e-04 8.69e-03 11/99 F2R; LCP2; FLNA; GATA3; ENTPD1; CD9; PTPN6; PRKCH; RAB27A; ANXA2; GNA15
GO:0042113 B cell activation 2.98 6.24e-04 6.02e-03 12/109 TNFRSF4; ID2; ITGA4; CD38; IL7R; ITGB1; CD27; PTPN6; GPR183; CYLD; BCL2; LGALS1
GO:0031348 negative regulation of defense response 2.96 8.86e-03 4.51e-02 7/64 TNFRSF1B; CD96; PTGER4; HAVCR2; MFHAS1; IL2RA; GATA3
GO:0043112 receptor metabolic process 2.91 9.62e-03 4.86e-02 7/65 RAMP1; FLOT1; AHI1; ITGB1; CD9; HIF1A; ANXA2
GO:1903706 regulation of hemopoiesis 2.84 5.00e-05 7.64e-04 18/171 TNFRSF18; CD2; ID2; IL7R; CSF2; IRF4; ANXA1; IL2RA; GATA3; CD27; PTPN6; IFNG; HMGB1; HIF1A; CYLD; CCL3; LGALS1; SOD1
GO:0097191 extrinsic apoptotic signaling pathway 2.84 2.48e-03 1.70e-02 10/95 TNFRSF4; TNFRSF1B; MCL1; LMNA; SIAH2; CSF2; CD27; IFNG; CYLD; BCL2
GO:0048880 sensory system development 2.84 6.62e-03 3.59e-02 8/76 CYP1B1; AHI1; NINJ1; GATA3; VIM; HMGB1; HIF1A; BCL2
GO:0009636 response to toxic substance 2.81 5.84e-05 8.56e-04 18/173 PRDX1; CYP1B1; GSTK1; ANXA1; AAED1; TXN; GATA3; RGS10; CD27; CALM1; MT2A; CCL5; CCL3; CCL4L2; BCL2; MBP; KLF2; SOD1
GO:0031349 positive regulation of defense response 2.77 1.81e-04 2.41e-03 16/156 GBP5; PTGER4; HAVCR2; IRF4; FLOT1; MFHAS1; BIRC3; CRTAM; LAG3; HMGB1; CYLD; CCL5; CCL3; CCL3L3; CCR7; OSM
GO:0006909 phagocytosis 2.76 4.91e-03 2.89e-02 9/88 RAP1A; AIF1; ANXA1; ITGB1; HMGB1; RAB27A; PECAM1; SIRPG; CALR
GO:0023061 signal release 2.75 1.99e-03 1.46e-02 11/108 RAP1A; DPP4; CD38; RAB11FIP1; ANXA1; GATA3; IFNG; HIF1A; CALM1; CCL5; OSM
GO:0018212 peptidyl-tyrosine modification 2.68 2.48e-03 1.70e-02 11/111 TNFRSF18; CBLB; CSF2; SLA; CD44; PTPN6; IFNG; CCL5; ABI3; PECAM1; OSM
GO:0050878 regulation of body fluid levels 2.62 1.25e-03 1.03e-02 13/134 F2R; LCP2; FLNA; GATA3; ENTPD1; CD9; PTPN6; PRKCH; HIF1A; RAB27A; ANXA2; GNA15; MT-CO2
GO:0009615 response to virus 2.56 1.04e-03 9.01e-03 14/148 XCL1; LYST; CXCL10; PIM2; FLNA; BIRC3; IL2RA; GATA3; PRF1; IFNG; RPS15A; CCL5; CCL4L2; BCL2
GO:1904951 positive regulation of establishment of protein localization 2.55 2.11e-04 2.71e-03 18/191 TNFRSF4; CD58; CD2; CD38; PTGER4; F2R; HAVCR2; FLNA; CRTAM; GATA3; IFNG; HMGB1; GZMB; HIF1A; CCL3; BCL2; MBP; OSM
GO:0007015 actin filament organization 2.53 2.56e-03 1.71e-02 12/128 S100A10; PTGER4; AIF1; FSCN1; FLNA; CORO1B; ITGB1; LIMA1; GPR65; CCR7; BCL2; DSTN
GO:0048732 gland development 2.48 4.56e-03 2.74e-02 11/120 RAP1A; ID2; LBH; HRH2; ANXA1; GATA3; HIF1A; BCL2; TSPO; SOD1; MT-CO2
GO:0045088 regulation of innate immune response 2.47 1.44e-03 1.12e-02 14/153 GBP5; CD96; HAVCR2; IRF4; FLOT1; MFHAS1; BIRC3; CRTAM; LAG3; PTPN6; IFNG; HMGB1; CYLD; CCL5
GO:0051098 regulation of binding 2.46 1.05e-03 9.01e-03 15/165 S100A10; ID2; ITGA4; GZMA; IRF4; FLOT1; PIM2; TXN; GATA3; IFNG; HMGB1; CALM1; ANXA2; CYLD; BCL2
GO:0030099 myeloid cell differentiation 2.38 1.42e-03 1.12e-02 15/170 ID2; CSF2; SFXN1; IRF4; MFHAS1; GATA3; PTPN6; IFNG; HMGB1; GPR183; HIF1A; ANXA2; CCL3; CCR7; KLF2
GO:0035690 cellular response to drug 2.38 6.20e-03 3.46e-02 11/125 RAP1A; CYP1B1; AIF1; ANXA1; TXN; VIM; RGS10; MT2A; GNA15; KLF2; SOD1
GO:0051346 negative regulation of hydrolase activity 2.33 3.64e-03 2.31e-02 13/151 SIAH2; PPP1R2; SPINK2; GZMA; TNFAIP8; TIMP1; ANXA1; CD44; PPP1R14B; BIRC3; SPOCK2; CD27; CST7
GO:0002764 immune response-regulating signaling pathway 2.29 7.55e-04 7.01e-03 18/212 RAP1A; CD38; HAVCR2; LCP2; IRF4; FLOT1; MFHAS1; BIRC3; CD3D; GATA3; PTPN6; HMGB1; PRKCH; CALM1; CTSH; CYLD; CCR7; BCL2
GO:0052547 regulation of peptidase activity 2.24 5.08e-03 2.94e-02 13/157 SIAH2; SPINK2; F2R; TNFAIP8; TIMP1; CD44; BIRC3; SPOCK2; CD27; HMGB1; CTSH; MBP; CST7
GO:0051051 negative regulation of transport 2.18 8.70e-03 4.46e-02 12/149 TNFRSF4; TNFRSF1B; RAP1A; PTGER4; F2R; RAB11FIP1; ANXA1; TXN; HMGB1; CALM1; BCL2; OSM
GO:0043900 regulation of multi-organism process 2.10 8.47e-03 4.45e-02 13/167 HAVCR2; TIMP1; BIRC3; IL2RA; PRF1; IFNG; ANXA2; CCL5; CCL3; CCL4L2; BCL2; CALR; LGALS1
Factor 20 : 31 significant GO terms
GeneSet description enrichRatio pValue FDR GeneRatio geneSymbols
GO:0051131 chaperone-mediated protein complex assembly 19.10 3.82e-05 3.81e-03 4/12 HSP90AB1; PTGES3; CCT2; HSP90AA1
GO:1901998 toxin transport 11.50 3.36e-04 1.52e-02 4/20 CCT7; CCT5; TCP1; CCT2
GO:0008037 cell recognition 9.31 3.54e-05 3.81e-03 6/37 CCT7; CCT5; TCP1; CCT2; ALDOA; CORO1A
GO:0006457 protein folding 8.87 4.88e-15 3.58e-12 21/136 PDIA6; CCT7; GNAI2; DNAJB11; CCT5; CANX; HSP90AB1; TCP1; PPIA; CCT6A; ERP44; PTGES3; CCT2; HSP90B1; HSP90AA1; PDIA3; B2M; PPIB; P4HB; CDC37; CALR
GO:0070671 response to interleukin-12 8.20 3.07e-04 1.50e-02 5/35 TCP1; PPIA; TALDO1; CFL1; P4HB
GO:0009566 fertilization 7.98 3.52e-04 1.52e-02 5/36 CCT7; CCT5; TCP1; CCT2; ALDOA
GO:0051702 interaction with symbiont 7.56 4.56e-04 1.86e-02 5/38 NUCKS1; CFL1; GAPDH; CALM1; PPIB
GO:0048013 ephrin receptor signaling pathway 7.41 1.89e-03 4.61e-02 4/31 AP2M1; ACTB; RAC1; ARPC1B
GO:0002576 platelet degranulation 7.00 6.53e-04 2.18e-02 5/41 WDR1; SRGN; CD63; CALM1; ALDOA
GO:0071897 DNA biosynthetic process 6.15 3.88e-07 9.48e-05 12/112 CCT7; HNRNPD; CCT5; HSP90AB1; TCP1; PPIA; CCT6A; PTGES3; CCT2; HSP90AA1; KIAA0101; UFD1L
GO:0006898 receptor-mediated endocytosis 6.05 4.40e-05 3.81e-03 8/76 AP2M1; CANX; RAC1; CD63; HSP90B1; HSP90AA1; B2M; CALR
GO:0006909 phagocytosis 5.87 1.81e-05 2.65e-03 9/88 BRK1; GNB2L1; HSP90AB1; ACTB; RAC1; ARPC1B; HSP90AA1; CORO1A; CALR
GO:0060249 anatomical structure homeostasis 5.29 9.18e-08 3.37e-05 15/163 CCT7; HNRNPD; CCT5; HSP90AB1; TCP1; ACTB; RAC1; CCT6A; PTGES3; CCT2; HSP90AA1; B2M; ALDOA; CORO1A; CHMP4B
GO:0032200 telomere organization 5.22 4.68e-05 3.81e-03 9/99 CCT7; HNRNPD; CCT5; HSP90AB1; TCP1; CCT6A; PTGES3; CCT2; HSP90AA1
GO:0031647 regulation of protein stability 5.15 9.84e-07 1.80e-04 13/145 CCT7; ATP1B3; CCT5; HSP90AB1; TCP1; CCT6A; GAPDH; PTGES3; CCT2; HSP90AA1; PPIB; CDC37; CALR
GO:0071241 cellular response to inorganic substance 4.92 1.26e-03 3.55e-02 6/70 HNRNPD; B2M; MT2A; MT1E; MT1X; CALR
GO:0035966 response to topologically incorrect protein 4.88 8.03e-05 5.35e-03 9/106 PDIA6; DNAJB11; GNB2L1; HSP90AB1; ERP44; HSP90B1; HSP90AA1; CALR; UFD1L
GO:0034341 response to interferon-gamma 4.73 6.27e-04 2.18e-02 7/85 HSP90AB1; VIM; KIF5B; GAPDH; B2M; MT2A; CDC37
GO:0007015 actin filament organization 4.49 6.45e-05 4.73e-03 10/128 STMN1; TMSB10; BRK1; WDR1; RAC1; ARPC1B; CFL1; HSP90B1; ALDOA; CORO1A
GO:0010959 regulation of metal ion transport 4.47 8.84e-04 2.82e-02 7/90 GNAI2; ATP1B3; KIF5B; CD63; CALM1; B2M; CORO1A
GO:0032970 regulation of actin filament-based process 4.34 1.97e-04 1.03e-02 9/119 STMN1; TMSB10; BRK1; WDR1; ABRACL; RAC1; ARPC1B; CFL1; CORO1A
GO:0010038 response to metal ion 4.14 6.28e-04 2.18e-02 8/111 HNRNPD; PPP1CA; CALM1; B2M; MT2A; MT1E; MT1X; CALR
GO:0090066 regulation of anatomical structure size 4.04 1.55e-04 8.73e-03 10/142 TMSB10; BRK1; AP2M1; WDR1; HSP90AB1; RAC1; ARPC1B; CFL1; PPP1CA; CORO1A
GO:0051258 protein polymerization 3.86 9.95e-04 3.04e-02 8/119 STMN1; TMSB10; BRK1; RAC1; ARPC1B; HSP90AA1; CORO1A; UBE2S
GO:1902903 regulation of supramolecular fiber organization 3.80 1.11e-03 3.25e-02 8/121 STMN1; TMSB10; BRK1; WDR1; RAC1; ARPC1B; CFL1; CORO1A
GO:0043900 regulation of multi-organism process 3.78 1.30e-04 7.93e-03 11/167 IFI16; NUCKS1; PPIA; CFL1; GAPDH; PPIB; HACD3; P4HB; CHMP4B; CALR; UFD1L
GO:0035690 cellular response to drug 3.68 1.37e-03 3.72e-02 8/125 GNAI2; HNRNPD; GNB2L1; HSP90AB1; ACTB; VIM; HSP90B1; MT2A
GO:0034976 response to endoplasmic reticulum stress 3.27 1.57e-03 4.10e-02 9/158 PDIA6; DNAJB11; GNB2L1; ERP44; HSP90B1; PDIA3; P4HB; CALR; UFD1L
GO:1904951 positive regulation of establishment of protein localization 3.01 1.63e-03 4.11e-02 10/191 CCT7; CCT5; GNB2L1; HSP90AB1; TCP1; PPIA; CCT6A; KIF5B; GAPDH; CCT2
GO:0002446 neutrophil mediated immunity 2.82 5.88e-04 2.18e-02 13/265 PSMD14; WDR1; HSP90AB1; RAC1; PPIA; ERP44; TUBB4B; CD63; CCT2; HSP90AA1; B2M; ALDOA; PSMD3
GO:0036230 granulocyte activation 2.59 2.00e-03 4.74e-02 12/266 PSMD14; HSP90AB1; RAC1; PPIA; ERP44; TUBB4B; CD63; CCT2; HSP90AA1; B2M; ALDOA; PSMD3
Summary:
Factor 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20
Signif_GO_terms 20 54 30 101 17 56 87 38 54 14 0 0 90 77 38 26 36 51 145 31

3.1.1 Factors of interest

2: meiotic cell cycle, cytokinesis, chromosome segregation, cell cycle G2/M phase transition
3: response to interleukin, cell killing
4: interleukin production, cell killing
6: DNA damage response, regulation of cell division
7: immune response, interleukin production, response to chemokine, cell killing
8: leukocyte migration/proliferation
9: response to chemokine, immune response, leukocyte proliferation, cell killing, T cell activation
11: immune response, interleukin production, leukocyte migration, T cell activation
12: DNA conformation change, DNA replication
13: interleukin production, cell killing, leukocyte migration
14: interleukin production, leukocyte cell-cell adhesion
15: cell cycle checkpoint
18: response to chemokine, leukocyte migration, T cell activation, regulation of hemopoiesis
19: response to chemokine, type 2 immune response, interleukin production, leukocyte migration, leukocyte proliferation, cell killing, T & B cell activation

From the reference study:

Targeting CD5, RASA2, SOCS1, and CBLB promoted programs that are characterized by the induction of markers of activation states (e.g. IL2RA, TNFRSF18/GITR), cell cycle genes (e.g. MKI67, UBE2S, CENPF and TOP2A), and effector molecules (e.g GZMB).

Associated factors in GSFA:

CD5: 4, 7, 9
RASA2: 13, 18
SOCS1: 4, 12
CBLB: 1, 7, 8, 9, 18

From the reference study:

Targeting CD3D or LCP2 inhibited the cluster 10 activation program and promoted programs characterized by expression of resting state markers such as IL7R and CCR7.

Associated factors in GSFA

CD3D: 7
LCP2: 4, 7, 13, 19

3.2 Reactome Pathway Over-Representation Analysis

Gene sets: The Reactome pathway database.

Factor 1 : 44 significant Reactome pathways
GeneSet description enrichRatio pValue FDR GeneRatio geneSymbols
R-HSA-3371511 HSF1 activation 12.40 2.41e-05 0.002713 5/11 HSP90AB1; EEF1A1; PTGES3; HSP90AA1; YWHAE
R-HSA-983170 Antigen Presentation: Folding, assembly and peptide loading of class I MHC 10.00 2.71e-06 0.000801 7/19 HLA-A; HLA-E; HLA-C; HLA-B; HSPA5; B2M; CALR
R-HSA-3371568 Attenuation phase 9.89 4.72e-04 0.015475 4/11 HSP90AB1; FKBP4; PTGES3; HSP90AA1
R-HSA-389957 Prefoldin mediated transfer of substrate to CCT/TriC 8.59 4.04e-05 0.003258 6/19 PFDN2; CCT5; TCP1; CCT6A; PFDN5; CCT2
R-HSA-389960 Formation of tubulin folding intermediates by CCT/TriC 8.37 9.65e-04 0.025831 4/13 CCT5; TCP1; CCT6A; CCT2
R-HSA-389958 Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding 8.16 5.60e-05 0.003323 6/20 PFDN2; CCT5; TCP1; CCT6A; PFDN5; CCT2
R-HSA-3371571 HSF1-dependent transactivation 7.77 1.31e-03 0.029812 4/14 HSP90AB1; FKBP4; PTGES3; HSP90AA1
R-HSA-75067 Processing of Capped Intronless Pre-mRNA 6.18 9.91e-04 0.025831 5/22 SNRPE; SNRPG; SLBP; SNRPF; SNRPB
R-HSA-390471 Association of TriC/CCT with target proteins during biosynthesis 5.91 1.23e-03 0.029230 5/23 CCT5; TCP1; CCT6A; CCT2; NOP56
R-HSA-198933 Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell 5.01 3.78e-04 0.012879 7/38 HLA-A; HLA-E; HLA-C; HLA-B; CD3D; B2M; HCST
R-HSA-72165 mRNA Splicing - Minor Pathway 4.80 7.71e-05 0.003594 9/51 YBX1; SNRPE; SRSF7; SNRPG; SNRPF; SRSF2; SNRPD1; TXNL4A; SNRPB
R-HSA-1268020 Mitochondrial protein import 4.19 5.21e-04 0.016480 8/52 HSPD1; VDAC1; CHCHD2; CYC1; ATP5G1; TIMM13; TOMM40; CHCHD10
R-HSA-390466 Chaperonin-mediated protein folding 4.14 1.25e-03 0.029230 7/46 PFDN2; CCT5; TCP1; CCT6A; PFDN5; CCT2; NOP56
R-HSA-975956 Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) 3.97 1.63e-05 0.002401 13/89 RPS27; RPL22L1; EIF4G1; ETF1; RPS4X; RPL10; RPL35; RPLP0; RPS15A; UBA52; RPS19; RPL13A; RPL28
R-HSA-156902 Peptide chain elongation 3.84 4.96e-05 0.003323 12/85 RPS27; RPL22L1; EEF1A1; RPS4X; RPL10; RPL35; RPLP0; RPS15A; UBA52; RPS19; RPL13A; RPL28
R-HSA-109688 Cleavage of Growing Transcript in the Termination Region 3.82 9.79e-04 0.025831 8/57 SNRPE; SRSF7; SNRPG; SLBP; SNRPF; SRSF9; SRSF2; SNRPB
R-HSA-73856 RNA Polymerase II Transcription Termination 3.82 9.79e-04 0.025831 8/57 SNRPE; SRSF7; SNRPG; SLBP; SNRPF; SRSF9; SRSF2; SNRPB
R-HSA-156842 Eukaryotic Translation Elongation 3.75 6.28e-05 0.003323 12/87 RPS27; RPL22L1; EEF1A1; RPS4X; RPL10; RPL35; RPLP0; RPS15A; UBA52; RPS19; RPL13A; RPL28
R-HSA-391251 Protein folding 3.73 2.33e-03 0.047798 7/51 PFDN2; CCT5; TCP1; CCT6A; PFDN5; CCT2; NOP56
R-HSA-72764 Eukaryotic Translation Termination 3.71 7.04e-05 0.003466 12/88 RPS27; RPL22L1; ETF1; RPS4X; RPL10; RPL35; RPLP0; RPS15A; UBA52; RPS19; RPL13A; RPL28
R-HSA-72689 Formation of a pool of free 40S subunits 3.68 3.74e-05 0.003258 13/96 RPS27; RPL22L1; EIF1AX; RPS4X; RPL10; RPL35; EIF3F; RPLP0; RPS15A; UBA52; RPS19; RPL13A; RPL28
R-HSA-3371556 Cellular response to heat stress 3.63 1.38e-03 0.030563 8/60 HSP90AB1; EEF1A1; HSPA5; FKBP4; PTGES3; HSPH1; HSP90AA1; YWHAE
R-HSA-156827 L13a-mediated translational silencing of Ceruloplasmin expression 3.59 2.47e-05 0.002713 14/106 RPS27; RPL22L1; EIF4G1; EIF1AX; RPS4X; RPL10; RPL35; EIF3F; RPLP0; RPS15A; UBA52; RPS19; RPL13A; RPL28
R-HSA-72706 GTP hydrolysis and joining of the 60S ribosomal subunit 3.56 2.76e-05 0.002713 14/107 RPS27; RPL22L1; EIF4G1; EIF1AX; RPS4X; RPL10; RPL35; EIF3F; RPLP0; RPS15A; UBA52; RPS19; RPL13A; RPL28
R-HSA-192823 Viral mRNA Translation 3.52 2.30e-04 0.008154 11/85 RPS27; RPL22L1; RPS4X; RPL10; RPL35; RPLP0; RPS15A; UBA52; RPS19; RPL13A; RPL28
R-HSA-2408557 Selenocysteine synthesis 3.52 2.30e-04 0.008154 11/85 RPS27; RPL22L1; RPS4X; RPL10; RPL35; RPLP0; RPS15A; UBA52; RPS19; RPL13A; RPL28
R-HSA-1236975 Antigen processing-Cross presentation 3.40 1.12e-03 0.027515 9/72 HLA-A; HLA-E; HLA-C; HLA-B; B2M; CYBA; PSMA7; CALR; UBA52
R-HSA-72613 Eukaryotic Translation Initiation 3.34 5.67e-05 0.003323 14/114 RPS27; RPL22L1; EIF4G1; EIF1AX; RPS4X; RPL10; RPL35; EIF3F; RPLP0; RPS15A; UBA52; RPS19; RPL13A; RPL28
R-HSA-72737 Cap-dependent Translation Initiation 3.34 5.67e-05 0.003323 14/114 RPS27; RPL22L1; EIF4G1; EIF1AX; RPS4X; RPL10; RPL35; EIF3F; RPLP0; RPS15A; UBA52; RPS19; RPL13A; RPL28
R-HSA-927802 Nonsense-Mediated Decay (NMD) 3.34 1.07e-04 0.004532 13/106 RPS27; RPL22L1; EIF4G1; ETF1; RPS4X; RPL10; RPL35; RPLP0; RPS15A; UBA52; RPS19; RPL13A; RPL28
R-HSA-975957 Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) 3.34 1.07e-04 0.004532 13/106 RPS27; RPL22L1; EIF4G1; ETF1; RPS4X; RPL10; RPL35; RPLP0; RPS15A; UBA52; RPS19; RPL13A; RPL28
R-HSA-2408522 Selenoamino acid metabolism 3.30 2.24e-04 0.008154 12/99 RPS27; RPL22L1; EEF1E1; RPS4X; RPL10; RPL35; RPLP0; RPS15A; UBA52; RPS19; RPL13A; RPL28
R-HSA-8868773 rRNA processing in the nucleus and cytosol 3.24 2.10e-06 0.000801 20/168 EBNA1BP2; RPS27; WDR43; NCL; GNL3; RPL22L1; NHP2; RPS4X; RPL10; DKC1; BOP1; RPL35; DDX21; RPLP0; RPS15A; NOP56; UBA52; RPS19; RPL13A; RPL28
R-HSA-168255 Influenza Life Cycle 3.14 6.38e-05 0.003323 15/130 RPS27; RPL22L1; RPS4X; RPL10; RPL35; RPLP0; RAN; HSP90AA1; RPS15A; KPNB1; CALR; UBA52; RPS19; RPL13A; RPL28
R-HSA-72312 rRNA processing 3.11 4.00e-06 0.000886 20/175 EBNA1BP2; RPS27; WDR43; NCL; GNL3; RPL22L1; NHP2; RPS4X; RPL10; DKC1; BOP1; RPL35; DDX21; RPLP0; RPS15A; NOP56; UBA52; RPS19; RPL13A; RPL28
R-HSA-6791226 Major pathway of rRNA processing in the nucleolus and cytosol 3.10 1.34e-05 0.002366 18/158 EBNA1BP2; RPS27; WDR43; NCL; GNL3; RPL22L1; RPS4X; RPL10; BOP1; RPL35; DDX21; RPLP0; RPS15A; NOP56; UBA52; RPS19; RPL13A; RPL28
R-HSA-9609507 Protein localization 3.06 2.37e-03 0.047798 9/80 HSPD1; VDAC1; CHCHD2; CYC1; ATP5G1; TIMM13; UBA52; TOMM40; CHCHD10
R-HSA-168254 Influenza Infection 2.94 1.38e-04 0.005575 15/139 RPS27; RPL22L1; RPS4X; RPL10; RPL35; RPLP0; RAN; HSP90AA1; RPS15A; KPNB1; CALR; UBA52; RPS19; RPL13A; RPL28
R-HSA-1799339 SRP-dependent cotranslational protein targeting to membrane 2.80 1.67e-03 0.035244 11/107 RPS27; RPL22L1; RPS4X; RPL10; RPL35; RPLP0; RPS15A; UBA52; RPS19; RPL13A; RPL28
R-HSA-168273 Influenza Viral RNA Transcription and Replication 2.70 1.41e-03 0.030563 12/121 RPS27; RPL22L1; RPS4X; RPL10; RPL35; RPLP0; HSP90AA1; RPS15A; UBA52; RPS19; RPL13A; RPL28
R-HSA-72766 Translation 2.67 2.34e-06 0.000801 26/265 MRPL20; RPS27; MRPL3; RPL22L1; EIF4G1; ETF1; EEF1E1; EEF1A1; EIF1AX; RPS4X; RPL10; RPL35; MRPL17; EIF3F; MRPL11; RPLP0; MRPS34; RPS15A; MRPL12; MRPL4; GADD45GIP1; UBA52; MRPS12; RPS19; RPL13A; RPL28
R-HSA-9010553 Regulation of expression of SLITs and ROBOs 2.59 8.50e-04 0.025102 14/147 RPS27; RPL22L1; EIF4G1; ETF1; RPS4X; RPL10; RPL35; RPLP0; RPS15A; PSMA7; UBA52; RPS19; RPL13A; RPL28
R-HSA-376176 Signaling by ROBO receptors 2.44 1.02e-03 0.025908 15/167 RPS27; RPL22L1; EIF4G1; ETF1; RPS4X; RPL10; RPL35; RPLP0; EVL; RPS15A; PSMA7; UBA52; RPS19; RPL13A; RPL28
R-HSA-71291 Metabolism of amino acids and derivatives 2.31 6.26e-04 0.019124 18/212 SRM; RPS27; ODC1; RPL22L1; EEF1E1; RPS4X; RPL10; RPL35; RPLP0; RPS15A; NDUFAB1; GCSH; PYCR1; PSMA7; UBA52; RPS19; RPL13A; RPL28
Factor 2 : 151 significant Reactome pathways
GeneSet description enrichRatio pValue FDR GeneRatio geneSymbols
R-HSA-156902 Peptide chain elongation 10.80 0.00e+00 0.00e+00 78/85 RPL22; RPL11; RPS8; RPL5; RPS27; RPS7; RPS27A; RPL31; RPL37A; RPL32; RPL15; RPSA; RPL14; RPL29; RPL24; RPL39L; RPL35A; RPL9; RPL34; RPS3A; RPL37; RPS23; RPS14; RPS18; RPS10; RPL10A; EEF1A1; RPS12; RPS4X; RPL39; RPL10; RPS20; RPL7; RPL30; RPL8; RPS6; RPL35; RPL12; RPL7A; RPLP2; RPL27A; RPS13; RPS3; RPS25; RPS24; RPS26; RPL41; RPL6; RPLP0; RPL21; RPS29; RPL4; RPLP1; RPS17; RPS2; RPS15A; RPL13; RPL26; RPL23A; RPL23; RPL19; RPL27; RPL38; RPS15; EEF2; RPL36; RPS28; RPL18A; UBA52; RPS16; RPS19; RPL18; RPL13A; RPS11; RPS9; RPL28; RPS5; RPL3
R-HSA-156842 Eukaryotic Translation Elongation 10.60 0.00e+00 0.00e+00 78/87 RPL22; RPL11; RPS8; RPL5; RPS27; RPS7; RPS27A; RPL31; RPL37A; RPL32; RPL15; RPSA; RPL14; RPL29; RPL24; RPL39L; RPL35A; RPL9; RPL34; RPS3A; RPL37; RPS23; RPS14; RPS18; RPS10; RPL10A; EEF1A1; RPS12; RPS4X; RPL39; RPL10; RPS20; RPL7; RPL30; RPL8; RPS6; RPL35; RPL12; RPL7A; RPLP2; RPL27A; RPS13; RPS3; RPS25; RPS24; RPS26; RPL41; RPL6; RPLP0; RPL21; RPS29; RPL4; RPLP1; RPS17; RPS2; RPS15A; RPL13; RPL26; RPL23A; RPL23; RPL19; RPL27; RPL38; RPS15; EEF2; RPL36; RPS28; RPL18A; UBA52; RPS16; RPS19; RPL18; RPL13A; RPS11; RPS9; RPL28; RPS5; RPL3
R-HSA-192823 Viral mRNA Translation 10.60 0.00e+00 0.00e+00 76/85 RPL22; RPL11; RPS8; RPL5; RPS27; RPS7; RPS27A; RPL31; RPL37A; RPL32; RPL15; RPSA; RPL14; RPL29; RPL24; RPL39L; RPL35A; RPL9; RPL34; RPS3A; RPL37; RPS23; RPS14; RPS18; RPS10; RPL10A; RPS12; RPS4X; RPL39; RPL10; RPS20; RPL7; RPL30; RPL8; RPS6; RPL35; RPL12; RPL7A; RPLP2; RPL27A; RPS13; RPS3; RPS25; RPS24; RPS26; RPL41; RPL6; RPLP0; RPL21; RPS29; RPL4; RPLP1; RPS17; RPS2; RPS15A; RPL13; RPL26; RPL23A; RPL23; RPL19; RPL27; RPL38; RPS15; RPL36; RPS28; RPL18A; UBA52; RPS16; RPS19; RPL18; RPL13A; RPS11; RPS9; RPL28; RPS5; RPL3
R-HSA-2408557 Selenocysteine synthesis 10.60 0.00e+00 0.00e+00 76/85 RPL22; RPL11; RPS8; RPL5; RPS27; RPS7; RPS27A; RPL31; RPL37A; RPL32; RPL15; RPSA; RPL14; RPL29; RPL24; RPL39L; RPL35A; RPL9; RPL34; RPS3A; RPL37; RPS23; RPS14; RPS18; RPS10; RPL10A; RPS12; RPS4X; RPL39; RPL10; RPS20; RPL7; RPL30; RPL8; RPS6; RPL35; RPL12; RPL7A; RPLP2; RPL27A; RPS13; RPS3; RPS25; RPS24; RPS26; RPL41; RPL6; RPLP0; RPL21; RPS29; RPL4; RPLP1; RPS17; RPS2; RPS15A; RPL13; RPL26; RPL23A; RPL23; RPL19; RPL27; RPL38; RPS15; RPL36; RPS28; RPL18A; UBA52; RPS16; RPS19; RPL18; RPL13A; RPS11; RPS9; RPL28; RPS5; RPL3
R-HSA-975956 Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) 10.20 0.00e+00 0.00e+00 77/89 RPL22; RPL11; RPS8; RPL5; RPS27; RPS7; RPS27A; RPL31; RPL37A; RPL32; RPL15; RPSA; RPL14; RPL29; RPL24; RPL39L; RPL35A; RPL9; RPL34; RPS3A; RPL37; RPS23; RPS14; RPS18; RPS10; RPL10A; RPS12; RPS4X; RPL39; RPL10; RPS20; RPL7; RPL30; PABPC1; RPL8; RPS6; RPL35; RPL12; RPL7A; RPLP2; RPL27A; RPS13; RPS3; RPS25; RPS24; RPS26; RPL41; RPL6; RPLP0; RPL21; RPS29; RPL4; RPLP1; RPS17; RPS2; RPS15A; RPL13; RPL26; RPL23A; RPL23; RPL19; RPL27; RPL38; RPS15; RPL36; RPS28; RPL18A; UBA52; RPS16; RPS19; RPL18; RPL13A; RPS11; RPS9; RPL28; RPS5; RPL3
R-HSA-72764 Eukaryotic Translation Termination 10.20 0.00e+00 0.00e+00 76/88 RPL22; RPL11; RPS8; RPL5; RPS27; RPS7; RPS27A; RPL31; RPL37A; RPL32; RPL15; RPSA; RPL14; RPL29; RPL24; RPL39L; RPL35A; RPL9; RPL34; RPS3A; RPL37; RPS23; RPS14; RPS18; RPS10; RPL10A; RPS12; RPS4X; RPL39; RPL10; RPS20; RPL7; RPL30; RPL8; RPS6; RPL35; RPL12; RPL7A; RPLP2; RPL27A; RPS13; RPS3; RPS25; RPS24; RPS26; RPL41; RPL6; RPLP0; RPL21; RPS29; RPL4; RPLP1; RPS17; RPS2; RPS15A; RPL13; RPL26; RPL23A; RPL23; RPL19; RPL27; RPL38; RPS15; RPL36; RPS28; RPL18A; UBA52; RPS16; RPS19; RPL18; RPL13A; RPS11; RPS9; RPL28; RPS5; RPL3
R-HSA-72689 Formation of a pool of free 40S subunits 9.60 0.00e+00 0.00e+00 78/96 RPL22; RPL11; RPS8; RPL5; RPS27; RPS7; RPS27A; RPL31; RPL37A; RPL32; RPL15; RPSA; RPL14; RPL29; RPL24; RPL39L; RPL35A; RPL9; RPL34; RPS3A; RPL37; RPS23; RPS14; RPS18; RPS10; RPL10A; RPS12; RPS4X; RPL39; RPL10; RPS20; RPL7; RPL30; EIF3E; RPL8; RPS6; RPL35; RPL12; RPL7A; RPLP2; RPL27A; RPS13; RPS3; RPS25; RPS24; RPS26; RPL41; RPL6; RPLP0; RPL21; RPS29; RPL4; RPLP1; RPS17; RPS2; RPS15A; RPL13; RPL26; RPL23A; RPL23; RPL19; RPL27; RPL38; RPS15; RPL36; RPS28; EIF3G; RPL18A; UBA52; RPS16; RPS19; RPL18; RPL13A; RPS11; RPS9; RPL28; RPS5; RPL3
R-HSA-2514853 Condensation of Prometaphase Chromosomes 9.46 9.36e-08 1.30e-06 8/10 NCAPH; SMC4; NCAPG; CCNB1; SMC2; CDK1; NCAPD2; CCNB2
R-HSA-2408522 Selenoamino acid metabolism 9.07 0.00e+00 0.00e+00 76/99 RPL22; RPL11; RPS8; RPL5; RPS27; RPS7; RPS27A; RPL31; RPL37A; RPL32; RPL15; RPSA; RPL14; RPL29; RPL24; RPL39L; RPL35A; RPL9; RPL34; RPS3A; RPL37; RPS23; RPS14; RPS18; RPS10; RPL10A; RPS12; RPS4X; RPL39; RPL10; RPS20; RPL7; RPL30; RPL8; RPS6; RPL35; RPL12; RPL7A; RPLP2; RPL27A; RPS13; RPS3; RPS25; RPS24; RPS26; RPL41; RPL6; RPLP0; RPL21; RPS29; RPL4; RPLP1; RPS17; RPS2; RPS15A; RPL13; RPL26; RPL23A; RPL23; RPL19; RPL27; RPL38; RPS15; RPL36; RPS28; RPL18A; UBA52; RPS16; RPS19; RPL18; RPL13A; RPS11; RPS9; RPL28; RPS5; RPL3
R-HSA-2299718 Condensation of Prophase Chromosomes 9.00 6.66e-14 1.20e-12 16/21 HIST2H2AC; H3F3A; SMC4; H2AFZ; CCNB1; HIST1H4C; H2AFV; NCAPG2; SMC2; H2AFX; NCAPD3; CDK1; KMT5A; PLK1; H3F3B; NCAPH2
R-HSA-156827 L13a-mediated translational silencing of Ceruloplasmin expression 8.81 0.00e+00 0.00e+00 79/106 RPL22; RPL11; RPS8; RPL5; RPS27; RPS7; RPS27A; RPL31; RPL37A; RPL32; RPL15; RPSA; RPL14; RPL29; RPL24; RPL39L; RPL35A; RPL9; RPL34; RPS3A; RPL37; RPS23; RPS14; RPS18; RPS10; RPL10A; RPS12; RPS4X; RPL39; RPL10; RPS20; RPL7; RPL30; PABPC1; EIF3E; RPL8; RPS6; RPL35; RPL12; RPL7A; RPLP2; RPL27A; RPS13; RPS3; RPS25; RPS24; RPS26; RPL41; RPL6; RPLP0; RPL21; RPS29; RPL4; RPLP1; RPS17; RPS2; RPS15A; RPL13; RPL26; RPL23A; RPL23; RPL19; RPL27; RPL38; RPS15; RPL36; RPS28; EIF3G; RPL18A; UBA52; RPS16; RPS19; RPL18; RPL13A; RPS11; RPS9; RPL28; RPS5; RPL3
R-HSA-983189 Kinesins 8.74 2.46e-14 4.55e-13 17/23 KIF2C; TUBA4A; KIF15; CENPE; KIFC1; KIF4A; TUBB4B; KIF18A; KIF5B; KIF20B; KIF11; TUBA1B; TUBA1A; TUBA1C; RACGAP1; KIF23; KIF22
R-HSA-927802 Nonsense-Mediated Decay (NMD) 8.70 0.00e+00 0.00e+00 78/106 RPL22; RPL11; PNRC2; RPS8; RPL5; RPS27; RPS7; RPS27A; RPL31; RPL37A; RPL32; RPL15; RPSA; RPL14; RPL29; RPL24; RPL39L; RPL35A; RPL9; RPL34; RPS3A; RPL37; RPS23; RPS14; RPS18; RPS10; RPL10A; RPS12; RPS4X; RPL39; RPL10; RPS20; RPL7; RPL30; PABPC1; RPL8; RPS6; RPL35; RPL12; RPL7A; RPLP2; RPL27A; RPS13; RPS3; RPS25; RPS24; RPS26; RPL41; RPL6; RPLP0; RPL21; RPS29; RPL4; RPLP1; RPS17; RPS2; RPS15A; RPL13; RPL26; RPL23A; RPL23; RPL19; RPL27; RPL38; RPS15; RPL36; RPS28; RPL18A; UBA52; RPS16; RPS19; RPL18; RPL13A; RPS11; RPS9; RPL28; RPS5; RPL3
R-HSA-975957 Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) 8.70 0.00e+00 0.00e+00 78/106 RPL22; RPL11; PNRC2; RPS8; RPL5; RPS27; RPS7; RPS27A; RPL31; RPL37A; RPL32; RPL15; RPSA; RPL14; RPL29; RPL24; RPL39L; RPL35A; RPL9; RPL34; RPS3A; RPL37; RPS23; RPS14; RPS18; RPS10; RPL10A; RPS12; RPS4X; RPL39; RPL10; RPS20; RPL7; RPL30; PABPC1; RPL8; RPS6; RPL35; RPL12; RPL7A; RPLP2; RPL27A; RPS13; RPS3; RPS25; RPS24; RPS26; RPL41; RPL6; RPLP0; RPL21; RPS29; RPL4; RPLP1; RPS17; RPS2; RPS15A; RPL13; RPL26; RPL23A; RPL23; RPL19; RPL27; RPL38; RPS15; RPL36; RPS28; RPL18A; UBA52; RPS16; RPS19; RPL18; RPL13A; RPS11; RPS9; RPL28; RPS5; RPL3
R-HSA-72706 GTP hydrolysis and joining of the 60S ribosomal subunit 8.62 0.00e+00 0.00e+00 78/107 RPL22; RPL11; RPS8; RPL5; RPS27; RPS7; RPS27A; RPL31; RPL37A; RPL32; RPL15; RPSA; RPL14; RPL29; RPL24; RPL39L; RPL35A; RPL9; RPL34; RPS3A; RPL37; RPS23; RPS14; RPS18; RPS10; RPL10A; RPS12; RPS4X; RPL39; RPL10; RPS20; RPL7; RPL30; EIF3E; RPL8; RPS6; RPL35; RPL12; RPL7A; RPLP2; RPL27A; RPS13; RPS3; RPS25; RPS24; RPS26; RPL41; RPL6; RPLP0; RPL21; RPS29; RPL4; RPLP1; RPS17; RPS2; RPS15A; RPL13; RPL26; RPL23A; RPL23; RPL19; RPL27; RPL38; RPS15; RPL36; RPS28; EIF3G; RPL18A; UBA52; RPS16; RPS19; RPL18; RPL13A; RPS11; RPS9; RPL28; RPS5; RPL3
R-HSA-1799339 SRP-dependent cotranslational protein targeting to membrane 8.39 0.00e+00 0.00e+00 76/107 RPL22; RPL11; RPS8; RPL5; RPS27; RPS7; RPS27A; RPL31; RPL37A; RPL32; RPL15; RPSA; RPL14; RPL29; RPL24; RPL39L; RPL35A; RPL9; RPL34; RPS3A; RPL37; RPS23; RPS14; RPS18; RPS10; RPL10A; RPS12; RPS4X; RPL39; RPL10; RPS20; RPL7; RPL30; RPL8; RPS6; RPL35; RPL12; RPL7A; RPLP2; RPL27A; RPS13; RPS3; RPS25; RPS24; RPS26; RPL41; RPL6; RPLP0; RPL21; RPS29; RPL4; RPLP1; RPS17; RPS2; RPS15A; RPL13; RPL26; RPL23A; RPL23; RPL19; RPL27; RPL38; RPS15; RPL36; RPS28; RPL18A; UBA52; RPS16; RPS19; RPL18; RPL13A; RPS11; RPS9; RPL28; RPS5; RPL3
R-HSA-156711 Polo-like kinase mediated events 8.27 2.80e-06 3.35e-05 7/10 CENPF; CCNB1; FOXM1; CCNB2; PKMYT1; PLK1; MYBL2
R-HSA-72613 Eukaryotic Translation Initiation 8.19 0.00e+00 0.00e+00 79/114 RPL22; RPL11; RPS8; RPL5; RPS27; RPS7; RPS27A; RPL31; RPL37A; RPL32; RPL15; RPSA; RPL14; RPL29; RPL24; RPL39L; RPL35A; RPL9; RPL34; RPS3A; RPL37; RPS23; RPS14; RPS18; RPS10; RPL10A; RPS12; RPS4X; RPL39; RPL10; RPS20; RPL7; RPL30; PABPC1; EIF3E; RPL8; RPS6; RPL35; RPL12; RPL7A; RPLP2; RPL27A; RPS13; RPS3; RPS25; RPS24; RPS26; RPL41; RPL6; RPLP0; RPL21; RPS29; RPL4; RPLP1; RPS17; RPS2; RPS15A; RPL13; RPL26; RPL23A; RPL23; RPL19; RPL27; RPL38; RPS15; RPL36; RPS28; EIF3G; RPL18A; UBA52; RPS16; RPS19; RPL18; RPL13A; RPS11; RPS9; RPL28; RPS5; RPL3
R-HSA-72737 Cap-dependent Translation Initiation 8.19 0.00e+00 0.00e+00 79/114 RPL22; RPL11; RPS8; RPL5; RPS27; RPS7; RPS27A; RPL31; RPL37A; RPL32; RPL15; RPSA; RPL14; RPL29; RPL24; RPL39L; RPL35A; RPL9; RPL34; RPS3A; RPL37; RPS23; RPS14; RPS18; RPS10; RPL10A; RPS12; RPS4X; RPL39; RPL10; RPS20; RPL7; RPL30; PABPC1; EIF3E; RPL8; RPS6; RPL35; RPL12; RPL7A; RPLP2; RPL27A; RPS13; RPS3; RPS25; RPS24; RPS26; RPL41; RPL6; RPLP0; RPL21; RPS29; RPL4; RPLP1; RPS17; RPS2; RPS15A; RPL13; RPL26; RPL23A; RPL23; RPL19; RPL27; RPL38; RPS15; RPL36; RPS28; EIF3G; RPL18A; UBA52; RPS16; RPS19; RPL18; RPL13A; RPS11; RPS9; RPL28; RPS5; RPL3
R-HSA-72695 Formation of the ternary complex, and subsequently, the 43S complex 7.88 0.00e+00 0.00e+00 32/48 RPS8; RPS27; RPS7; RPS27A; RPSA; RPS3A; RPS23; RPS14; RPS18; RPS10; RPS12; RPS4X; RPS20; EIF3E; RPS6; RPS13; RPS3; RPS25; RPS24; RPS26; RPS29; RPS17; RPS2; RPS15A; RPS15; RPS28; EIF3G; RPS16; RPS19; RPS11; RPS9; RPS5
R-HSA-5625886 Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 7.52 7.14e-06 7.71e-05 7/11 HIST2H2AC; H3F3A; H2AFZ; HIST1H4C; H2AFV; H2AFX; H3F3B
R-HSA-140342 Apoptosis induced DNA fragmentation 7.52 7.14e-06 7.71e-05 7/11 HMGB2; HIST1H1A; HIST1H1C; HIST1H1E; HIST1H1D; HIST1H1B; HMGB1
R-HSA-211227 Activation of DNA fragmentation factor 7.52 7.14e-06 7.71e-05 7/11 HMGB2; HIST1H1A; HIST1H1C; HIST1H1E; HIST1H1D; HIST1H1B; HMGB1
R-HSA-168273 Influenza Viral RNA Transcription and Replication 7.42 0.00e+00 0.00e+00 76/121 RPL22; RPL11; RPS8; RPL5; RPS27; RPS7; RPS27A; RPL31; RPL37A; RPL32; RPL15; RPSA; RPL14; RPL29; RPL24; RPL39L; RPL35A; RPL9; RPL34; RPS3A; RPL37; RPS23; RPS14; RPS18; RPS10; RPL10A; RPS12; RPS4X; RPL39; RPL10; RPS20; RPL7; RPL30; RPL8; RPS6; RPL35; RPL12; RPL7A; RPLP2; RPL27A; RPS13; RPS3; RPS25; RPS24; RPS26; RPL41; RPL6; RPLP0; RPL21; RPS29; RPL4; RPLP1; RPS17; RPS2; RPS15A; RPL13; RPL26; RPL23A; RPL23; RPL19; RPL27; RPL38; RPS15; RPL36; RPS28; RPL18A; UBA52; RPS16; RPS19; RPL18; RPL13A; RPS11; RPS9; RPL28; RPS5; RPL3
R-HSA-72649 Translation initiation complex formation 7.09 0.00e+00 0.00e+00 33/55 RPS8; RPS27; RPS7; RPS27A; RPSA; RPS3A; RPS23; RPS14; RPS18; RPS10; RPS12; RPS4X; RPS20; PABPC1; EIF3E; RPS6; RPS13; RPS3; RPS25; RPS24; RPS26; RPS29; RPS17; RPS2; RPS15A; RPS15; RPS28; EIF3G; RPS16; RPS19; RPS11; RPS9; RPS5
R-HSA-168255 Influenza Life Cycle 7.00 0.00e+00 0.00e+00 77/130 RPL22; RPL11; RPS8; RPL5; RPS27; RPS7; RPS27A; XPO1; RPL31; RPL37A; RPL32; RPL15; RPSA; RPL14; RPL29; RPL24; RPL39L; RPL35A; RPL9; RPL34; RPS3A; RPL37; RPS23; RPS14; RPS18; RPS10; RPL10A; RPS12; RPS4X; RPL39; RPL10; RPS20; RPL7; RPL30; RPL8; RPS6; RPL35; RPL12; RPL7A; RPLP2; RPL27A; RPS13; RPS3; RPS25; RPS24; RPS26; RPL41; RPL6; RPLP0; RPL21; RPS29; RPL4; RPLP1; RPS17; RPS2; RPS15A; RPL13; RPL26; RPL23A; RPL23; RPL19; RPL27; RPL38; RPS15; RPL36; RPS28; RPL18A; UBA52; RPS16; RPS19; RPL18; RPL13A; RPS11; RPS9; RPL28; RPS5; RPL3
R-HSA-72662 Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S 6.96 0.00e+00 0.00e+00 33/56 RPS8; RPS27; RPS7; RPS27A; RPSA; RPS3A; RPS23; RPS14; RPS18; RPS10; RPS12; RPS4X; RPS20; PABPC1; EIF3E; RPS6; RPS13; RPS3; RPS25; RPS24; RPS26; RPS29; RPS17; RPS2; RPS15A; RPS15; RPS28; EIF3G; RPS16; RPS19; RPS11; RPS9; RPS5
R-HSA-427359 SIRT1 negatively regulates rRNA expression 6.89 1.59e-05 1.60e-04 7/12 HIST2H2AC; H3F3A; H2AFZ; HIST1H4C; H2AFV; H2AFX; H3F3B
R-HSA-5334118 DNA methylation 6.89 1.59e-05 1.60e-04 7/12 HIST2H2AC; H3F3A; H2AFZ; HIST1H4C; H2AFV; H2AFX; H3F3B
R-HSA-73728 RNA Polymerase I Promoter Opening 6.89 1.59e-05 1.60e-04 7/12 HIST2H2AC; H3F3A; H2AFZ; HIST1H4C; H2AFV; H2AFX; H3F3B
R-HSA-72702 Ribosomal scanning and start codon recognition 6.88 0.00e+00 0.00e+00 32/55 RPS8; RPS27; RPS7; RPS27A; RPSA; RPS3A; RPS23; RPS14; RPS18; RPS10; RPS12; RPS4X; RPS20; EIF3E; RPS6; RPS13; RPS3; RPS25; RPS24; RPS26; RPS29; RPS17; RPS2; RPS15A; RPS15; RPS28; EIF3G; RPS16; RPS19; RPS11; RPS9; RPS5
R-HSA-606279 Deposition of new CENPA-containing nucleosomes at the centromere 6.80 6.87e-13 1.19e-11 19/33 HIST2H2AC; CENPL; CENPA; HJURP; H2AFZ; CENPU; CENPK; CENPH; NPM1; HIST1H4C; CENPW; H2AFV; H2AFX; MIS18BP1; CASC5; OIP5; CENPN; CENPM; MIS18A
R-HSA-774815 Nucleosome assembly 6.80 6.87e-13 1.19e-11 19/33 HIST2H2AC; CENPL; CENPA; HJURP; H2AFZ; CENPU; CENPK; CENPH; NPM1; HIST1H4C; CENPW; H2AFV; H2AFX; MIS18BP1; CASC5; OIP5; CENPN; CENPM; MIS18A
R-HSA-168254 Influenza Infection 6.72 0.00e+00 0.00e+00 79/139 RPL22; RPL11; RPS8; RPL5; RPS27; RPS7; RPS27A; XPO1; RPL31; RPL37A; RPL32; RPL15; RPSA; RPL14; RPL29; RPL24; RPL39L; RPL35A; RPL9; RPL34; RPS3A; RPL37; RPS23; RPS14; RPS18; RPS10; RPL10A; RPS12; SLC25A6; RPS4X; RPL39; RPL10; RPS20; RPL7; RPL30; RPL8; RPS6; RPL35; RPL12; RPL7A; RPLP2; RPL27A; RPS13; RPS3; RPS25; RPS24; RPS26; RPL41; RPL6; RPLP0; RPL21; RPS29; RPL4; RPLP1; RPS17; RPS2; RPS15A; RPL13; RPL26; RPL23A; RPL23; RPL19; RPL27; KPNA2; RPL38; RPS15; RPL36; RPS28; RPL18A; UBA52; RPS16; RPS19; RPL18; RPL13A; RPS11; RPS9; RPL28; RPS5; RPL3
R-HSA-5626467 RHO GTPases activate IQGAPs 6.65 1.34e-06 1.67e-05 9/16 CALM2; TUBA4A; ACTB; TUBB4B; TUBA1B; TUBA1A; TUBA1C; CALM1; CALM3
R-HSA-9010553 Regulation of expression of SLITs and ROBOs 6.35 0.00e+00 0.00e+00 79/147 RPL22; RPL11; RPS8; RPL5; RPS27; RPS7; RPS27A; RPL31; RPL37A; RPL32; RPL15; RPSA; RPL14; RPL29; RPL24; RPL39L; RPL35A; RPL9; RPL34; RPS3A; RPL37; RPS23; RPS14; RPS18; RPS10; RPL10A; RPS12; RPS4X; RPL39; RPL10; RPS20; RPL7; RPL30; PABPC1; RPL8; RPS6; RPL35; RPL12; RPL7A; RPLP2; RPL27A; RPS13; PSMC3; RPS3; RPS25; RPS24; RPS26; RPL41; RPL6; RPLP0; RPL21; RPS29; RPL4; RPLP1; RPS17; RPS2; RPS15A; RPL13; RPL26; UBB; RPL23A; RPL23; RPL19; RPL27; RPL38; RPS15; RPL36; RPS28; RPL18A; UBA52; RPS16; RPS19; RPL18; RPL13A; RPS11; RPS9; RPL28; RPS5; RPL3
R-HSA-2500257 Resolution of Sister Chromatid Cohesion 5.97 0.00e+00 0.00e+00 47/93 CDCA8; CDC20; KIF2C; RPS27; NUF2; CENPL; CENPF; CENPA; XPO1; BUB1; SPC25; SGOL2; TUBA4A; SGOL1; CENPE; MAD2L1; CENPU; CENPK; CCNB1; CENPH; SPDL1; SMC1A; RAD21; TUBB4B; KIF18A; CKAP5; INCENP; CDCA5; ZWINT; CDK1; SMC3; BUB3; TUBA1B; TUBA1A; TUBA1C; BUB1B; CASC5; CCNB2; PLK1; CENPN; AURKB; SKA2; BIRC5; NDC80; SPC24; RANGAP1; CENPM
R-HSA-389977 Post-chaperonin tubulin folding pathway 5.91 7.42e-04 6.26e-03 5/10 TUBA4A; TUBB4B; TUBA1B; TUBA1A; TUBA1C
R-HSA-179409 APC-Cdc20 mediated degradation of Nek2A 5.91 4.06e-07 5.29e-06 11/22 CDC20; NEK2; RPS27A; MAD2L1; BUB3; BUB1B; UBB; CDC27; ANAPC11; UBE2C; UBA52
R-HSA-69273 Cyclin A/B1/B2 associated events during G2/M transition 5.91 4.88e-06 5.54e-05 9/18 XPO1; CCNA2; CCNB1; CDK1; FOXM1; CCNB2; PKMYT1; PLK1; CDC25B
R-HSA-157858 Gap junction trafficking and regulation 5.91 2.09e-04 1.87e-03 6/12 TUBA4A; ACTB; TUBB4B; TUBA1B; TUBA1A; TUBA1C
R-HSA-190828 Gap junction trafficking 5.91 2.09e-04 1.87e-03 6/12 TUBA4A; ACTB; TUBB4B; TUBA1B; TUBA1A; TUBA1C
R-HSA-6791226 Major pathway of rRNA processing in the nucleolus and cytosol 5.76 0.00e+00 0.00e+00 77/158 RPL22; RPL11; RPS8; RPL5; RPS27; RPS7; RPS27A; RPL31; RPL37A; RPL32; RPL15; RPSA; RPL14; RPL29; RPL24; RPL39L; RPL35A; RPL9; RPL34; RPS3A; RPL37; RPS23; RPS14; RPS18; RPS10; RPL10A; RPS12; RPS4X; RPL39; RPL10; RPS20; RPL7; RPL30; RPL8; RPS6; RPL35; RPL12; RPL7A; RPLP2; RPL27A; RPS13; RPS3; RPS25; RPS24; RPS26; RPL41; RPL6; RPLP0; RPL21; RPS29; RPL4; RPLP1; RPS17; RPS2; RPS15A; NOB1; RPL13; RPL26; RPL23A; RPL23; RPL19; RPL27; RPL38; RPS15; RPL36; RPS28; RPL18A; UBA52; RPS16; RPS19; RPL18; RPL13A; RPS11; RPS9; RPL28; RPS5; RPL3
R-HSA-376176 Signaling by ROBO receptors 5.59 0.00e+00 0.00e+00 79/167 RPL22; RPL11; RPS8; RPL5; RPS27; RPS7; RPS27A; RPL31; RPL37A; RPL32; RPL15; RPSA; RPL14; RPL29; RPL24; RPL39L; RPL35A; RPL9; RPL34; RPS3A; RPL37; RPS23; RPS14; RPS18; RPS10; RPL10A; RPS12; RPS4X; RPL39; RPL10; RPS20; RPL7; RPL30; PABPC1; RPL8; RPS6; RPL35; RPL12; RPL7A; RPLP2; RPL27A; RPS13; PSMC3; RPS3; RPS25; RPS24; RPS26; RPL41; RPL6; RPLP0; RPL21; RPS29; RPL4; RPLP1; RPS17; RPS2; RPS15A; RPL13; RPL26; UBB; RPL23A; RPL23; RPL19; RPL27; RPL38; RPS15; RPL36; RPS28; RPL18A; UBA52; RPS16; RPS19; RPL18; RPL13A; RPS11; RPS9; RPL28; RPS5; RPL3
R-HSA-141424 Amplification of signal from the kinetochores 5.52 0.00e+00 0.00e+00 35/75 CDCA8; CDC20; KIF2C; RPS27; NUF2; CENPL; CENPF; CENPA; XPO1; BUB1; SPC25; SGOL2; SGOL1; CENPE; MAD2L1; CENPU; CENPK; CENPH; SPDL1; KIF18A; CKAP5; INCENP; ZWINT; BUB3; BUB1B; CASC5; PLK1; CENPN; AURKB; SKA2; BIRC5; NDC80; SPC24; RANGAP1; CENPM
R-HSA-141444 Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal 5.52 0.00e+00 0.00e+00 35/75 CDCA8; CDC20; KIF2C; RPS27; NUF2; CENPL; CENPF; CENPA; XPO1; BUB1; SPC25; SGOL2; SGOL1; CENPE; MAD2L1; CENPU; CENPK; CENPH; SPDL1; KIF18A; CKAP5; INCENP; ZWINT; BUB3; BUB1B; CASC5; PLK1; CENPN; AURKB; SKA2; BIRC5; NDC80; SPC24; RANGAP1; CENPM
R-HSA-8876725 Protein methylation 5.45 3.60e-04 3.07e-03 6/13 CALM2; EEF1A1; CALM1; RPS2; EEF2; CALM3
R-HSA-2559584 Formation of Senescence-Associated Heterochromatin Foci (SAHF) 5.45 3.60e-04 3.07e-03 6/13 LMNB1; HIST1H1A; HIST1H1C; HIST1H1E; HIST1H1D; HIST1H1B
R-HSA-8868773 rRNA processing in the nucleus and cytosol 5.42 0.00e+00 0.00e+00 77/168 RPL22; RPL11; RPS8; RPL5; RPS27; RPS7; RPS27A; RPL31; RPL37A; RPL32; RPL15; RPSA; RPL14; RPL29; RPL24; RPL39L; RPL35A; RPL9; RPL34; RPS3A; RPL37; RPS23; RPS14; RPS18; RPS10; RPL10A; RPS12; RPS4X; RPL39; RPL10; RPS20; RPL7; RPL30; RPL8; RPS6; RPL35; RPL12; RPL7A; RPLP2; RPL27A; RPS13; RPS3; RPS25; RPS24; RPS26; RPL41; RPL6; RPLP0; RPL21; RPS29; RPL4; RPLP1; RPS17; RPS2; RPS15A; NOB1; RPL13; RPL26; RPL23A; RPL23; RPL19; RPL27; RPL38; RPS15; RPL36; RPS28; RPL18A; UBA52; RPS16; RPS19; RPL18; RPL13A; RPS11; RPS9; RPL28; RPS5; RPL3
R-HSA-2468052 Establishment of Sister Chromatid Cohesion 5.37 1.27e-03 1.02e-02 5/11 SMC1A; ESCO2; RAD21; CDCA5; SMC3
R-HSA-68877 Mitotic Prometaphase 5.34 0.00e+00 0.00e+00 66/146 CDCA8; CDC20; KIF2C; RPS27; NUF2; CENPL; NEK2; CENPF; CENPA; XPO1; NCAPH; BUB1; SPC25; SGOL2; TUBA4A; SGOL1; SMC4; NCAPG; CEP135; CENPE; MAD2L1; CENPU; CENPK; CCNB1; CENPH; SPDL1; TUBB; SMC1A; RAD21; CEP78; SMC2; CDK5RAP2; CNTRL; ODF2; TUBB4B; KIF18A; CKAP5; INCENP; CDCA5; CEP57; ZWINT; CDK1; SMC3; BUB3; NCAPD2; TUBA1B; TUBA1A; TUBA1C; CENPJ; MZT1; BUB1B; CASC5; CEP152; CCNB2; PLK1; CENPN; AURKB; TUBG1; SKA2; BIRC5; NDC80; SPC24; HAUS8; RANGAP1; CENPM; PCNT
R-HSA-212300 PRC2 methylates histones and DNA 5.32 1.44e-05 1.51e-04 9/20 HIST2H2AC; H3F3A; H2AFZ; HIST1H4C; H2AFV; EZH2; PHF19; H2AFX; H3F3B
R-HSA-174048 APC/C:Cdc20 mediated degradation of Cyclin B 5.32 1.44e-05 1.51e-04 9/20 CDC20; RPS27A; CCNB1; CDK1; UBB; CDC27; ANAPC11; UBE2C; UBA52
R-HSA-5663220 RHO GTPases Activate Formins 5.28 0.00e+00 0.00e+00 42/94 CDCA8; CDC20; KIF2C; RPS27; NUF2; CENPL; CENPF; CENPA; XPO1; BUB1; SPC25; SGOL2; TUBA4A; SGOL1; CENPE; MAD2L1; CENPU; CENPK; CENPH; SPDL1; ACTB; TUBB4B; KIF18A; CKAP5; INCENP; ZWINT; BUB3; TUBA1B; TUBA1A; TUBA1C; DIAPH3; BUB1B; CASC5; PLK1; CENPN; AURKB; SKA2; BIRC5; NDC80; SPC24; RANGAP1; CENPM
R-HSA-72312 rRNA processing 5.20 0.00e+00 0.00e+00 77/175 RPL22; RPL11; RPS8; RPL5; RPS27; RPS7; RPS27A; RPL31; RPL37A; RPL32; RPL15; RPSA; RPL14; RPL29; RPL24; RPL39L; RPL35A; RPL9; RPL34; RPS3A; RPL37; RPS23; RPS14; RPS18; RPS10; RPL10A; RPS12; RPS4X; RPL39; RPL10; RPS20; RPL7; RPL30; RPL8; RPS6; RPL35; RPL12; RPL7A; RPLP2; RPL27A; RPS13; RPS3; RPS25; RPS24; RPS26; RPL41; RPL6; RPLP0; RPL21; RPS29; RPL4; RPLP1; RPS17; RPS2; RPS15A; NOB1; RPL13; RPL26; RPL23A; RPL23; RPL19; RPL27; RPL38; RPS15; RPL36; RPS28; RPL18A; UBA52; RPS16; RPS19; RPL18; RPL13A; RPS11; RPS9; RPL28; RPS5; RPL3
R-HSA-69618 Mitotic Spindle Checkpoint 5.10 0.00e+00 0.00e+00 38/88 CDCA8; CDC20; KIF2C; RPS27; NUF2; CENPL; CENPF; CENPA; XPO1; BUB1; SPC25; SGOL2; SGOL1; CENPE; MAD2L1; CENPU; CENPK; CENPH; SPDL1; KIF18A; CKAP5; INCENP; ZWINT; BUB3; BUB1B; CASC5; PLK1; CENPN; AURKB; CDC27; SKA2; BIRC5; ANAPC11; NDC80; UBE2C; SPC24; RANGAP1; CENPM
R-HSA-912446 Meiotic recombination 5.00 3.26e-06 3.80e-05 11/26 HIST2H2AC; H3F3A; H2AFZ; MND1; HIST1H4C; RPA3; H2AFV; H2AFX; BRCA2; BRCA1; H3F3B
R-HSA-1221632 Meiotic synapsis 5.00 3.26e-06 3.80e-05 11/26 HIST2H2AC; H2AFZ; LMNB1; HIST1H4C; H2AFV; SMC1A; RAD21; H2AFX; SMC3; BRCA1; SUN2
R-HSA-6783310 Fanconi Anemia Pathway 4.98 7.94e-05 7.81e-04 8/19 USP1; UBE2T; RPS27A; FANCD2; RPA3; FANCI; UBB; UBA52
R-HSA-68884 Mitotic Telophase/Cytokinesis 4.92 2.02e-03 1.52e-02 5/12 SMC1A; RAD21; SMC3; KIF23; PLK1
R-HSA-171306 Packaging Of Telomere Ends 4.92 2.02e-03 1.52e-02 5/12 HIST2H2AC; H2AFZ; HIST1H4C; H2AFV; H2AFX
R-HSA-141405 Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components 4.87 2.69e-04 2.36e-03 7/17 CDC20; MAD2L1; BUB3; BUB1B; CDC27; ANAPC11; UBE2C
R-HSA-141430 Inactivation of APC/C via direct inhibition of the APC/C complex 4.87 2.69e-04 2.36e-03 7/17 CDC20; MAD2L1; BUB3; BUB1B; CDC27; ANAPC11; UBE2C
R-HSA-8854518 AURKA Activation by TPX2 4.73 1.24e-10 1.99e-09 22/55 NEK2; TUBA4A; CEP135; HMMR; TUBB; CEP78; CDK5RAP2; CNTRL; ODF2; TUBB4B; CKAP5; CEP57; CDK1; TUBA1A; CENPJ; CEP152; PLK1; TUBG1; TPX2; AURKA; HAUS8; PCNT
R-HSA-8982491 Glycogen metabolism 4.73 9.08e-04 7.45e-03 6/15 CALM2; RPS27A; CALM1; UBB; UBA52; CALM3
R-HSA-5358565 Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) 4.73 7.00e-03 4.22e-02 4/10 MSH6; RPA3; PCNA; LIG1
R-HSA-2565942 Regulation of PLK1 Activity at G2/M Transition 4.55 1.77e-11 2.91e-10 25/65 NEK2; RPS27A; TUBA4A; CEP135; CCNB1; TUBB; CEP78; CDK5RAP2; CNTRL; ODF2; TUBB4B; CKAP5; CEP57; CDK1; TUBA1A; CENPJ; CEP152; CCNB2; PLK1; UBB; TUBG1; AURKA; HAUS8; UBA52; PCNT
R-HSA-389960 Formation of tubulin folding intermediates by CCT/TriC 4.55 3.06e-03 2.15e-02 5/13 TUBA4A; TUBB4B; TUBA1B; TUBA1A; TUBA1C
R-HSA-73886 Chromosome Maintenance 4.48 4.21e-10 6.67e-09 22/58 HIST2H2AC; CENPL; CENPA; HJURP; H2AFZ; CENPU; CENPK; CENPH; NPM1; HIST1H4C; CENPW; RPA3; H2AFV; H2AFX; MIS18BP1; CASC5; OIP5; CENPN; PCNA; LIG1; CENPM; MIS18A
R-HSA-2672351 Stimuli-sensing channels 4.43 1.35e-03 1.05e-02 6/16 CALM2; RPS27A; CALM1; UBB; UBA52; CALM3
R-HSA-176412 Phosphorylation of the APC/C 4.43 1.35e-03 1.05e-02 6/16 CCNB1; CDK1; PLK1; CDC27; ANAPC11; UBE2C
R-HSA-110312 Translesion synthesis by REV1 4.43 1.35e-03 1.05e-02 6/16 MAD2L2; RPS27A; RPA3; UBB; PCNA; UBA52
R-HSA-5656121 Translesion synthesis by POLI 4.43 1.35e-03 1.05e-02 6/16 MAD2L2; RPS27A; RPA3; UBB; PCNA; UBA52
R-HSA-71291 Metabolism of amino acids and derivatives 4.35 0.00e+00 0.00e+00 78/212 RPL22; RPL11; RPS8; RPL5; RPS27; RPS7; RPS27A; RPL31; RPL37A; RPL32; RPL15; RPSA; RPL14; RPL29; RPL24; RPL39L; RPL35A; RPL9; RPL34; RPS3A; RPL37; RPS23; RPS14; RPS18; RPS10; RPL10A; RPS12; RPS4X; RPL39; RPL10; RPS20; RPL7; RPL30; RPL8; RPS6; RPL35; RPL12; RPL7A; RPLP2; RPL27A; RPS13; PSMC3; RPS3; RPS25; RPS24; RPS26; RPL41; RPL6; RPLP0; PXMP2; RPL21; RPS29; RPL4; RPLP1; RPS17; RPS2; RPS15A; RPL13; RPL26; RPL23A; RPL23; RPL19; RPL27; RPL38; RPS15; RPL36; RPS28; RPL18A; UBA52; RPS16; RPS19; RPL18; RPL13A; RPS11; RPS9; RPL28; RPS5; RPL3
R-HSA-380259 Loss of Nlp from mitotic centrosomes 4.32 1.42e-08 2.10e-07 19/52 NEK2; TUBA4A; CEP135; TUBB; CEP78; CDK5RAP2; CNTRL; ODF2; TUBB4B; CKAP5; CEP57; CDK1; TUBA1A; CENPJ; CEP152; PLK1; TUBG1; HAUS8; PCNT
R-HSA-380284 Loss of proteins required for interphase microtubule organization from the centrosome 4.32 1.42e-08 2.10e-07 19/52 NEK2; TUBA4A; CEP135; TUBB; CEP78; CDK5RAP2; CNTRL; ODF2; TUBB4B; CKAP5; CEP57; CDK1; TUBA1A; CENPJ; CEP152; PLK1; TUBG1; HAUS8; PCNT
R-HSA-1500620 Meiosis 4.30 2.22e-07 3.03e-06 16/44 HIST2H2AC; H3F3A; H2AFZ; MND1; LMNB1; HIST1H4C; RPA3; H2AFV; SMC1A; RAD21; H2AFX; SMC3; BRCA2; BRCA1; H3F3B; SUN2
R-HSA-380320 Recruitment of NuMA to mitotic centrosomes 4.26 1.31e-09 2.03e-08 22/61 NEK2; TUBA4A; CEP135; TUBB; CEP78; CDK5RAP2; CNTRL; ODF2; TUBB4B; CKAP5; CEP57; CDK1; TUBA1B; TUBA1A; TUBA1C; CENPJ; MZT1; CEP152; PLK1; TUBG1; HAUS8; PCNT
R-HSA-977225 Amyloid fiber formation 4.25 1.20e-04 1.12e-03 9/25 HIST2H2AC; H3F3A; RPS27A; H2AFZ; HIST1H4C; H2AFX; UBB; H3F3B; UBA52
R-HSA-983231 Factors involved in megakaryocyte development and platelet production 4.21 4.17e-09 6.37e-08 21/59 KIF2C; H3F3A; TUBA4A; KIF15; CENPE; KIFC1; ACTB; KIF4A; TUBB4B; KIF18A; KIF5B; KIF20B; KIF11; TUBA1B; TUBA1A; TUBA1C; RACGAP1; CBX5; KIF23; KIF22; H3F3B
R-HSA-2559582 Senescence-Associated Secretory Phenotype (SASP) 4.20 3.19e-07 4.22e-06 16/45 CDKN2C; HIST2H2AC; H3F3A; RPS27A; H2AFZ; CCNA2; HIST1H4C; H2AFV; H2AFX; UBB; CDC27; H3F3B; ANAPC11; UBE2C; CDKN2D; UBA52
R-HSA-422475 Axon guidance 4.18 0.00e+00 0.00e+00 91/257 RPL22; RPL11; RPS8; RPL5; RPS27; RPS7; SPTBN1; RPS27A; RPL31; RPL37A; TUBA4A; RPL32; RPL15; RPSA; RPL14; RPL29; RPL24; RPL39L; RPL35A; RPL9; RPL34; RPS3A; RPL37; RPS23; RPS14; RPS18; RPS10; RPL10A; HSP90AB1; RPS12; ACTB; KIF4A; RPS4X; RPL39; RPL10; FGFR1; RPS20; SDCBP; RPL7; RPL30; PABPC1; RPL8; RPS6; RPL35; RPL12; RPL7A; TUBB4B; RPLP2; RPL27A; RPS13; PSMC3; RPS3; RPS25; RPS24; KRAS; TUBA1B; TUBA1A; TUBA1C; RPS26; RPL41; RPL6; RPLP0; RPL21; RPS29; RPL4; RPLP1; RPS17; RPS2; RPS15A; RPL13; RPL26; UBB; RPL23A; RPL23; RPL19; RPL27; RPL38; RPS15; RPL36; RPS28; RPL18A; UBA52; RPS16; RPS19; RPL18; RPL13A; RPS11; RPS9; RPL28; RPS5; RPL3
R-HSA-2559586 DNA Damage/Telomere Stress Induced Senescence 4.17 1.09e-05 1.17e-04 12/34 HIST2H2AC; H2AFZ; CCNA2; LMNB1; HIST1H1A; HIST1H1C; HIST1H4C; HIST1H1E; HIST1H1D; HIST1H1B; H2AFV; H2AFX
R-HSA-5655862 Translesion synthesis by POLK 4.17 1.94e-03 1.48e-02 6/17 MAD2L2; RPS27A; RPA3; UBB; PCNA; UBA52
R-HSA-2555396 Mitotic Metaphase and Anaphase 4.16 0.00e+00 0.00e+00 56/159 CDCA8; CDC20; KIF2C; RPS27; NUF2; CENPL; CENPF; CENPA; RPS27A; XPO1; BUB1; SPC25; SGOL2; TUBA4A; SGOL1; CENPE; MAD2L1; CENPU; CENPK; CENPH; LMNB1; PTTG1; SPDL1; FBXO5; SMC1A; RAD21; TUBB4B; KIF18A; CKAP5; PSMC3; INCENP; CDCA5; ZWINT; SMC3; BUB3; TUBA1B; TUBA1A; TUBA1C; TMPO; VRK1; BUB1B; CASC5; PLK1; CENPN; AURKB; UBB; CDC27; SKA2; BIRC5; ANAPC11; NDC80; UBE2C; SPC24; UBA52; RANGAP1; CENPM
R-HSA-389958 Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding 4.14 8.57e-04 7.09e-03 7/20 TUBA4A; ACTB; TUBB4B; TUBA1B; TUBA1A; TUBA1C; PFDN5
R-HSA-68882 Mitotic Anaphase 4.11 0.00e+00 0.00e+00 55/158 CDCA8; CDC20; KIF2C; RPS27; NUF2; CENPL; CENPF; CENPA; RPS27A; XPO1; BUB1; SPC25; SGOL2; TUBA4A; SGOL1; CENPE; MAD2L1; CENPU; CENPK; CENPH; LMNB1; PTTG1; SPDL1; SMC1A; RAD21; TUBB4B; KIF18A; CKAP5; PSMC3; INCENP; CDCA5; ZWINT; SMC3; BUB3; TUBA1B; TUBA1A; TUBA1C; TMPO; VRK1; BUB1B; CASC5; PLK1; CENPN; AURKB; UBB; CDC27; SKA2; BIRC5; ANAPC11; NDC80; UBE2C; SPC24; UBA52; RANGAP1; CENPM
R-HSA-2467813 Separation of Sister Chromatids 4.10 0.00e+00 0.00e+00 52/150 CDCA8; CDC20; KIF2C; RPS27; NUF2; CENPL; CENPF; CENPA; RPS27A; XPO1; BUB1; SPC25; SGOL2; TUBA4A; SGOL1; CENPE; MAD2L1; CENPU; CENPK; CENPH; PTTG1; SPDL1; SMC1A; RAD21; TUBB4B; KIF18A; CKAP5; PSMC3; INCENP; CDCA5; ZWINT; SMC3; BUB3; TUBA1B; TUBA1A; TUBA1C; BUB1B; CASC5; PLK1; CENPN; AURKB; UBB; CDC27; SKA2; BIRC5; ANAPC11; NDC80; UBE2C; SPC24; UBA52; RANGAP1; CENPM
R-HSA-68886 M Phase 4.04 0.00e+00 0.00e+00 90/263 CDCA8; CDC20; KIF2C; HIST2H2AC; RPS27; NUF2; CENPL; NEK2; CENPF; H3F3A; CENPA; RPS27A; XPO1; NCAPH; BUB1; SPC25; SGOL2; TUBA4A; SGOL1; SMC4; NCAPG; CEP135; H2AFZ; CENPE; MAD2L1; CENPU; CENPK; CCNB1; CENPH; LMNB1; PTTG1; SPDL1; HIST1H4C; TUBB; FBXO5; H2AFV; NCAPG2; SMC1A; RAD21; CEP78; SMC2; CDK5RAP2; CNTRL; ODF2; TUBB4B; KIF18A; CKAP5; PSMC3; INCENP; CDCA5; CEP57; H2AFX; NCAPD3; ZWINT; CDK1; SMC3; BUB3; NCAPD2; TUBA1B; TUBA1A; TUBA1C; TMPO; KMT5A; CENPJ; MZT1; VRK1; BUB1B; CASC5; CEP152; CCNB2; KIF23; PLK1; CENPN; AURKB; UBB; TUBG1; CDC27; SKA2; H3F3B; BIRC5; ANAPC11; NDC80; UBE2C; SPC24; HAUS8; UBA52; RANGAP1; CENPM; NCAPH2; PCNT
R-HSA-5620912 Anchoring of the basal body to the plasma membrane 4.01 2.60e-08 3.77e-07 20/59 NEK2; TUBA4A; CEP135; SCLT1; TUBB; CEP78; CDK5RAP2; CNTRL; ODF2; TUBB4B; CKAP5; CEP57; CDK1; TUBA1A; CENPJ; CEP152; PLK1; TUBG1; HAUS8; PCNT
R-HSA-195258 RHO GTPase Effectors 3.99 0.00e+00 0.00e+00 56/166 CDCA8; CDC20; KIF2C; HIST2H2AC; RPS27; NUF2; CENPL; KIF14; CENPF; H3F3A; CENPA; CALM2; XPO1; BUB1; SPC25; SGOL2; TUBA4A; SGOL1; H2AFZ; CENPE; MAD2L1; CENPU; CENPK; CENPH; SPDL1; HIST1H4C; ACTB; H2AFV; TUBB4B; KIF18A; CKAP5; INCENP; H2AFX; KIF5B; ZWINT; BUB3; TUBA1B; TUBA1A; TUBA1C; DIAPH3; CALM1; BUB1B; CASC5; PRC1; PLK1; CENPN; AURKB; SKA2; H3F3B; BIRC5; NDC80; SPC24; CALM3; YWHAH; RANGAP1; CENPM
R-HSA-499943 Interconversion of nucleotide di- and triphosphates 3.94 2.71e-03 1.93e-02 6/18 RRM2; DTYMK; RRM1; DUT; DCTPP1; TYMS
R-HSA-380270 Recruitment of mitotic centrosome proteins and complexes 3.94 3.60e-08 5.06e-07 20/60 NEK2; TUBA4A; CEP135; TUBB; CEP78; CDK5RAP2; CNTRL; ODF2; TUBB4B; CKAP5; CEP57; CDK1; TUBA1A; CENPJ; MZT1; CEP152; PLK1; TUBG1; HAUS8; PCNT
R-HSA-380287 Centrosome maturation 3.94 3.60e-08 5.06e-07 20/60 NEK2; TUBA4A; CEP135; TUBB; CEP78; CDK5RAP2; CNTRL; ODF2; TUBB4B; CKAP5; CEP57; CDK1; TUBA1A; CENPJ; MZT1; CEP152; PLK1; TUBG1; HAUS8; PCNT
R-HSA-5250924 B-WICH complex positively regulates rRNA expression 3.94 1.06e-04 1.02e-03 10/30 HIST2H2AC; H3F3A; H2AFZ; DEK; HIST1H4C; ACTB; H2AFV; H2AFX; POLR1D; H3F3B
R-HSA-8864260 Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors 3.94 6.20e-03 3.79e-02 5/15 NPM1; DEK; ATAD2; YEATS4; MYBL2
R-HSA-1474165 Reproduction 3.94 8.78e-07 1.11e-05 16/48 HIST2H2AC; H3F3A; H2AFZ; MND1; LMNB1; HIST1H4C; RPA3; H2AFV; SMC1A; RAD21; H2AFX; SMC3; BRCA2; BRCA1; H3F3B; SUN2
R-HSA-6811434 COPI-dependent Golgi-to-ER retrograde traffic 3.86 5.43e-07 6.97e-06 17/52 KIF2C; TUBA4A; KIF15; CENPE; KIFC1; KIF4A; TUBB4B; KIF18A; KIF5B; KIF20B; KIF11; TUBA1B; TUBA1A; TUBA1C; RACGAP1; KIF23; KIF22
R-HSA-427389 ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression 3.76 1.62e-03 1.25e-02 7/22 HIST2H2AC; H3F3A; H2AFZ; HIST1H4C; H2AFV; H2AFX; H3F3B
R-HSA-389957 Prefoldin mediated transfer of substrate to CCT/TriC 3.73 3.68e-03 2.49e-02 6/19 TUBA4A; ACTB; TUBB4B; TUBA1A; TUBA1C; PFDN5
R-HSA-539107 Activation of E2F1 target genes at G1/S 3.73 3.68e-03 2.49e-02 6/19 RRM2; FBXO5; CDK1; TK1; TYMS; PCNA
R-HSA-69205 G1/S-Specific Transcription 3.73 3.68e-03 2.49e-02 6/19 RRM2; FBXO5; CDK1; TK1; TYMS; PCNA
R-HSA-72766 Translation 3.70 0.00e+00 0.00e+00 83/265 RPL22; RPL11; RPS8; RPL5; RPS27; RPS7; RPS27A; RPL31; RPL37A; RPL32; RPL15; RPSA; RPL14; RPL29; RPL24; RPL39L; RPL35A; RPL9; RPL34; RPS3A; RPL37; RPS23; RPS14; RPS18; RPS10; RPL10A; EEF1A1; RPS12; RPS4X; RPL39; RPL10; RPS20; RPL7; RPL30; PABPC1; EIF3E; RPL8; RPS6; RPL35; RPL12; RPL7A; RPLP2; CARS; RPL27A; RPS13; RPS3; RPS25; RPS24; MRPL51; RPS26; RPL41; RPL6; RPLP0; RPL21; RPS29; RPL4; RPLP1; RPS17; RPS2; RPS15A; RPL13; RPL26; RPL23A; RPL23; RPL19; RPL27; RPL38; RPS15; EEF2; RPL36; RPS28; EIF3G; RPL18A; UBA52; RPS16; RPS19; RPL18; RPL13A; RPS11; RPS9; RPL28; RPS5; RPL3
R-HSA-69278 Cell Cycle, Mitotic 3.70 0.00e+00 0.00e+00 112/358 CDCA8; CDC20; KIF2C; CDKN2C; HIST2H2AC; RPS27; CKS1B; NUF2; CENPL; NEK2; CENPF; H3F3A; RRM2; CENPA; RPS27A; XPO1; NCAPH; BUB1; SPC25; SGOL2; TUBA4A; SGOL1; SMC4; NCAPG; CEP135; H2AFZ; CENPE; MAD2L1; CCNA2; CENPU; CENPK; CCNB1; CENPH; LMNB1; PTTG1; HMMR; SPDL1; HIST1H4C; TUBB; HSP90AB1; FBXO5; RPA3; H2AFV; DBF4; NCAPG2; SMC1A; ESCO2; RAD21; CEP78; SMC2; CDK5RAP2; CNTRL; ODF2; TUBB4B; KIF18A; CKAP5; PSMC3; INCENP; CDCA5; CEP57; H2AFX; NCAPD3; ZWINT; CDK1; SMC3; BUB3; FOXM1; NCAPD2; TUBA1B; TUBA1A; TUBA1C; TMPO; KMT5A; CENPJ; MZT1; VRK1; BUB1B; CASC5; CEP152; CCNB2; KIF23; PKMYT1; PLK1; CENPN; AURKB; UBB; TOP2A; TUBG1; CDC27; SKA2; H3F3B; TK1; BIRC5; ANAPC11; TYMS; NDC80; CDC25B; PCNA; TPX2; MYBL2; UBE2C; AURKA; CDKN2D; SPC24; HAUS8; UBA52; LIG1; RANGAP1; CENPM; GTSE1; NCAPH2; PCNT
R-HSA-5689901 Metalloprotease DUBs 3.55 4.89e-03 3.14e-02 6/20 HIST2H2AC; RPS27A; HIST1H2AH; UBB; BRCA1; UBA52
R-HSA-5696397 Gap-filling DNA repair synthesis and ligation in GG-NER 3.55 4.89e-03 3.14e-02 6/20 RPS27A; RPA3; UBB; PCNA; UBA52; LIG1
R-HSA-68875 Mitotic Prophase 3.53 2.86e-07 3.84e-06 20/67 HIST2H2AC; H3F3A; SMC4; H2AFZ; CCNB1; LMNB1; HIST1H4C; H2AFV; NCAPG2; SMC2; H2AFX; NCAPD3; CDK1; TMPO; KMT5A; VRK1; CCNB2; PLK1; H3F3B; NCAPH2
R-HSA-5663205 Infectious disease 3.51 0.00e+00 0.00e+00 91/306 RPL22; RPL11; RPS8; RPL5; RPS27; RPS7; CALM2; RPS27A; XPO1; RPL31; RPL37A; RPL32; RPL15; RPSA; RPL14; RPL29; RPL24; RPL39L; RPL35A; RPL9; RPL34; RPS3A; RPL37; RPS23; RPS14; NPM1; RPS18; RPS10; RPL10A; HSP90AB1; RPS12; SLC25A6; RPS4X; RPL39; RPL10; RPS20; RPL7; RPL30; RPL8; PSIP1; RPS6; RPL35; RPL12; RPL7A; RPLP2; RPL27A; RPS13; PSMC3; RPS3; RPS25; RPS24; RPS26; RPL41; RPL6; RPLP0; RPL21; RPS29; CALM1; RPL4; RPLP1; RPS17; RPS2; RPS15A; RPL13; RPL26; UBB; RPL23A; RPL23; RPL19; RPL27; KPNA2; RPL38; RPS15; EEF2; RPL36; RPS28; RPL18A; UBA52; RPS16; RPS19; CALM3; LIG1; RPL18; RPL13A; RPS11; RPS9; RPL28; RPS5; RANBP1; RPL3; RANGAP1
R-HSA-1640170 Cell Cycle 3.47 0.00e+00 0.00e+00 125/426 CDCA8; CDC20; KIF2C; CDKN2C; HIST2H2AC; RPS27; CKS1B; NUF2; CENPL; NEK2; CENPF; H3F3A; RRM2; CENPA; RPS27A; XPO1; NCAPH; BUB1; SPC25; SGOL2; TUBA4A; HJURP; SGOL1; SMC4; WHSC1; NCAPG; CEP135; H2AFZ; CENPE; MAD2L1; CCNA2; MND1; CENPU; CENPK; CCNB1; CENPH; LMNB1; PTTG1; HMMR; SPDL1; NPM1; HIST1H4C; TUBB; HSP90AB1; CENPW; FBXO5; RPA3; H2AFV; DBF4; NCAPG2; SMC1A; ESCO2; RAD21; CEP78; SMC2; CDK5RAP2; CNTRL; ODF2; TUBB4B; KIF18A; CKAP5; PSMC3; INCENP; CDCA5; CEP57; H2AFX; NCAPD3; ZWINT; CDK1; SMC3; BUB3; FOXM1; RHNO1; NCAPD2; TUBA1B; TUBA1A; TUBA1C; TMPO; KMT5A; CENPJ; BRCA2; MZT1; MIS18BP1; VRK1; BUB1B; CASC5; OIP5; CEP152; CCNB2; KIF23; PKMYT1; PLK1; CENPN; AURKB; UBB; TOP2A; TUBG1; BRCA1; CDC27; SKA2; H3F3B; TK1; BIRC5; ANAPC11; TYMS; NDC80; CDC25B; PCNA; TPX2; MYBL2; UBE2C; AURKA; CDKN2D; SPC24; HAUS8; UBA52; LIG1; YWHAH; SUN2; RANGAP1; CENPM; GTSE1; NCAPH2; MIS18A; PCNT
R-HSA-194315 Signaling by Rho GTPases 3.43 0.00e+00 0.00e+00 60/207 CDCA8; CDC20; KIF2C; HIST2H2AC; RPS27; NUF2; CENPL; KIF14; CENPF; H3F3A; CENPA; CALM2; XPO1; BUB1; SPC25; SGOL2; TUBA4A; SGOL1; ECT2; H2AFZ; CENPE; MAD2L1; CENPU; DEPDC1B; CENPK; CENPH; SPDL1; HIST1H4C; ACTB; H2AFV; TUBB4B; KIF18A; CKAP5; INCENP; H2AFX; KIF5B; ZWINT; BUB3; TUBA1B; TUBA1A; TUBA1C; RACGAP1; DIAPH3; CALM1; ARHGAP11A; BUB1B; CASC5; PRC1; PLK1; CENPN; AURKB; SKA2; H3F3B; BIRC5; NDC80; SPC24; CALM3; YWHAH; RANGAP1; CENPM
R-HSA-1266738 Developmental Biology 3.37 0.00e+00 0.00e+00 101/354 RPL22; RPL11; RPS8; RPL5; HIST2H2AC; RPS27; H3F3A; RPS7; SPTBN1; RPS27A; RPL31; RPL37A; TUBA4A; RPL32; RPL15; RPSA; RPL14; RPL29; RPL24; RPL39L; RPL35A; RPL9; H2AFZ; RPL34; RPS3A; RPL37; RPS23; RPS14; HIST1H4C; RPS18; RPS10; RPL10A; HSP90AB1; RPS12; ACTB; H2AFV; EZH2; KIF4A; RPS4X; RPL39; RPL10; FGFR1; RPS20; SDCBP; RPL7; RPL30; PABPC1; RPL8; RPS6; RPL35; RPL12; RPL7A; TUBB4B; RPLP2; RPL27A; RPS13; PSMC3; RPS3; RPS25; H2AFX; RPS24; KRAS; TUBA1B; TUBA1A; TUBA1C; RPS26; RPL41; RPL6; RPLP0; RPL21; RPS29; RPL4; RPLP1; RPS17; RPS2; RPS15A; CTCF; RPL13; RPL26; UBB; RPL23A; RPL23; RPL19; KRT10; RPL27; RPL38; H3F3B; RPS15; RPL36; RPS28; RPL18A; UBA52; RPS16; RPS19; RPL18; RPL13A; RPS11; RPS9; RPL28; RPS5; RPL3
R-HSA-69275 G2/M Transition 3.35 1.30e-12 2.21e-11 40/141 NEK2; CENPF; RPS27A; XPO1; TUBA4A; CEP135; CCNA2; CCNB1; HMMR; TUBB; HSP90AB1; CEP78; CDK5RAP2; CNTRL; ODF2; TUBB4B; CKAP5; PSMC3; CEP57; CDK1; FOXM1; TUBA1B; TUBA1A; TUBA1C; CENPJ; MZT1; CEP152; CCNB2; PKMYT1; PLK1; UBB; TUBG1; CDC25B; TPX2; MYBL2; AURKA; HAUS8; UBA52; GTSE1; PCNT
R-HSA-1912408 Pre-NOTCH Transcription and Translation 3.31 3.67e-03 2.49e-02 7/25 HIST2H2AC; H3F3A; H2AFZ; HIST1H4C; H2AFV; H2AFX; H3F3B
R-HSA-437239 Recycling pathway of L1 3.31 3.67e-03 2.49e-02 7/25 TUBA4A; ACTB; KIF4A; TUBB4B; TUBA1B; TUBA1A; TUBA1C
R-HSA-453274 Mitotic G2-G2/M phases 3.31 2.15e-12 3.59e-11 40/143 NEK2; CENPF; RPS27A; XPO1; TUBA4A; CEP135; CCNA2; CCNB1; HMMR; TUBB; HSP90AB1; CEP78; CDK5RAP2; CNTRL; ODF2; TUBB4B; CKAP5; PSMC3; CEP57; CDK1; FOXM1; TUBA1B; TUBA1A; TUBA1C; CENPJ; MZT1; CEP152; CCNB2; PKMYT1; PLK1; UBB; TUBG1; CDC25B; TPX2; MYBL2; AURKA; HAUS8; UBA52; GTSE1; PCNT
R-HSA-5625740 RHO GTPases activate PKNs 3.26 2.12e-03 1.57e-02 8/29 HIST2H2AC; H3F3A; H2AFZ; HIST1H4C; H2AFV; H2AFX; H3F3B; YWHAH
R-HSA-5620924 Intraflagellar transport 3.22 8.14e-03 4.84e-02 6/22 TUBA4A; WDR34; TUBB4B; TUBA1B; TUBA1A; TUBA1C
R-HSA-201722 Formation of the beta-catenin:TCF transactivating complex 3.18 4.66e-03 3.04e-02 7/26 HIST2H2AC; H3F3A; H2AFZ; HIST1H4C; H2AFV; H2AFX; H3F3B
R-HSA-8936459 RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function 3.18 4.66e-03 3.04e-02 7/26 HIST2H2AC; H3F3A; H2AFZ; HIST1H4C; H2AFV; H2AFX; H3F3B
R-HSA-69620 Cell Cycle Checkpoints 3.17 3.33e-16 6.28e-15 56/209 CDCA8; CDC20; KIF2C; RPS27; NUF2; CENPL; CENPF; CENPA; RPS27A; XPO1; BUB1; SPC25; SGOL2; SGOL1; WHSC1; CENPE; MAD2L1; CCNA2; CENPU; CENPK; CCNB1; CENPH; SPDL1; HIST1H4C; RPA3; DBF4; KIF18A; CKAP5; PSMC3; INCENP; H2AFX; ZWINT; CDK1; BUB3; RHNO1; BUB1B; CASC5; CCNB2; PKMYT1; PLK1; CENPN; AURKB; UBB; BRCA1; CDC27; SKA2; BIRC5; ANAPC11; NDC80; UBE2C; SPC24; UBA52; YWHAH; RANGAP1; CENPM; GTSE1
R-HSA-174143 APC/C-mediated degradation of cell cycle proteins 3.15 2.11e-06 2.56e-05 20/75 CDC20; NEK2; RPS27A; MAD2L1; CCNA2; CCNB1; PTTG1; FBXO5; PSMC3; CDK1; BUB3; BUB1B; PLK1; AURKB; UBB; CDC27; ANAPC11; UBE2C; AURKA; UBA52
R-HSA-453276 Regulation of mitotic cell cycle 3.15 2.11e-06 2.56e-05 20/75 CDC20; NEK2; RPS27A; MAD2L1; CCNA2; CCNB1; PTTG1; FBXO5; PSMC3; CDK1; BUB3; BUB1B; PLK1; AURKB; UBB; CDC27; ANAPC11; UBE2C; AURKA; UBA52
R-HSA-8852276 The role of GTSE1 in G2/M progression after G2 checkpoint 2.95 9.25e-05 9.01e-04 15/60 RPS27A; TUBA4A; CCNB1; HSP90AB1; TUBB4B; PSMC3; CDK1; TUBA1B; TUBA1A; TUBA1C; CCNB2; PLK1; UBB; UBA52; GTSE1
R-HSA-5693606 DNA Double Strand Break Response 2.95 4.16e-03 2.77e-02 8/32 RPS27A; WHSC1; HIST1H4C; H2AFX; UBB; BRCA1; KPNA2; UBA52
R-HSA-73777 RNA Polymerase I Chain Elongation 2.95 4.16e-03 2.77e-02 8/32 HIST2H2AC; H3F3A; H2AFZ; HIST1H4C; H2AFV; H2AFX; POLR1D; H3F3B
R-HSA-176814 Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins 2.91 3.86e-05 3.84e-04 17/69 CDC20; NEK2; RPS27A; MAD2L1; CCNA2; CCNB1; PTTG1; PSMC3; CDK1; BUB3; BUB1B; PLK1; UBB; CDC27; ANAPC11; UBE2C; UBA52
R-HSA-2559580 Oxidative Stress Induced Senescence 2.90 3.34e-04 2.90e-03 13/53 CDKN2C; HIST2H2AC; H3F3A; RPS27A; H2AFZ; HIST1H4C; H2AFV; EZH2; H2AFX; UBB; H3F3B; CDKN2D; UBA52
R-HSA-75153 Apoptotic execution phase 2.87 5.09e-03 3.20e-02 8/33 HMGB2; LMNB1; HIST1H1A; HIST1H1C; HIST1H1E; HIST1H1D; HIST1H1B; HMGB1
R-HSA-157579 Telomere Maintenance 2.87 5.09e-03 3.20e-02 8/33 HIST2H2AC; H2AFZ; HIST1H4C; RPA3; H2AFV; H2AFX; PCNA; LIG1
R-HSA-373760 L1CAM interactions 2.81 2.07e-03 1.54e-02 10/42 SPTBN1; TUBA4A; ACTB; KIF4A; FGFR1; SDCBP; TUBB4B; TUBA1B; TUBA1A; TUBA1C
R-HSA-5617833 Cilium Assembly 2.80 3.32e-06 3.82e-05 23/97 NEK2; TUBA4A; CEP135; SCLT1; TUBB; CEP78; CDK5RAP2; CNTRL; ODF2; WDR34; TUBB4B; CKAP5; CEP57; CDK1; TUBA1B; TUBA1A; TUBA1C; CENPJ; CEP152; PLK1; TUBG1; HAUS8; PCNT
R-HSA-176409 APC/C:Cdc20 mediated degradation of mitotic proteins 2.78 1.19e-04 1.12e-03 16/68 CDC20; NEK2; RPS27A; MAD2L1; CCNA2; CCNB1; PTTG1; PSMC3; CDK1; BUB3; BUB1B; UBB; CDC27; ANAPC11; UBE2C; UBA52
R-HSA-6791312 TP53 Regulates Transcription of Cell Cycle Genes 2.78 6.18e-03 3.79e-02 8/34 CCNA2; CCNB1; NPM1; E2F8; CDK1; CENPJ; PCNA; AURKA
R-HSA-4615885 SUMOylation of DNA replication proteins 2.78 6.18e-03 3.79e-02 8/34 CDCA8; INCENP; AURKB; TOP2A; BIRC5; PCNA; AURKA; RANGAP1
R-HSA-5250913 Positive epigenetic regulation of rRNA expression 2.75 2.50e-03 1.83e-02 10/43 HIST2H2AC; H3F3A; H2AFZ; DEK; HIST1H4C; ACTB; H2AFV; H2AFX; POLR1D; H3F3B
R-HSA-2559583 Cellular Senescence 2.69 6.92e-06 7.71e-05 23/101 CDKN2C; HIST2H2AC; H3F3A; RPS27A; H2AFZ; CCNA2; LMNB1; HIST1H1A; HIST1H1C; HIST1H4C; HIST1H1E; HIST1H1D; HIST1H1B; H2AFV; EZH2; H2AFX; UBB; CDC27; H3F3B; ANAPC11; UBE2C; CDKN2D; UBA52
R-HSA-176408 Regulation of APC/C activators between G1/S and early anaphase 2.66 2.04e-04 1.86e-03 16/71 CDC20; RPS27A; MAD2L1; CCNA2; CCNB1; FBXO5; PSMC3; CDK1; BUB3; BUB1B; PLK1; UBB; CDC27; ANAPC11; UBE2C; UBA52
R-HSA-8856688 Golgi-to-ER retrograde transport 2.61 1.69e-04 1.56e-03 17/77 KIF2C; TUBA4A; KIF15; CENPE; KIFC1; KIF4A; TUBB4B; KIF18A; KIF5B; KIF20B; KIF11; TUBA1B; TUBA1A; TUBA1C; RACGAP1; KIF23; KIF22
R-HSA-5685942 HDR through Homologous Recombination (HRR) 2.53 7.23e-03 4.33e-02 9/42 RPS27A; RPA3; RHNO1; RAD51AP1; BRCA2; UBB; BRCA1; PCNA; UBA52
R-HSA-1445148 Translocation of SLC2A4 (GLUT4) to the plasma membrane 2.51 4.98e-03 3.17e-02 10/47 CALM2; TUBA4A; ACTB; TUBB4B; TUBA1B; TUBA1A; TUBA1C; CALM1; CALM3; YWHAH
R-HSA-179419 APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint 2.51 9.70e-04 7.89e-03 14/66 CDC20; NEK2; RPS27A; MAD2L1; CCNA2; PSMC3; CDK1; BUB3; BUB1B; UBB; CDC27; ANAPC11; UBE2C; UBA52
R-HSA-5617472 Activation of anterior HOX genes in hindbrain development during early embryogenesis 2.47 8.48e-03 4.94e-02 9/43 HIST2H2AC; H3F3A; H2AFZ; HIST1H4C; H2AFV; EZH2; H2AFX; CTCF; H3F3B
R-HSA-5619507 Activation of HOX genes during differentiation 2.47 8.48e-03 4.94e-02 9/43 HIST2H2AC; H3F3A; H2AFZ; HIST1H4C; H2AFV; EZH2; H2AFX; CTCF; H3F3B
R-HSA-2132295 MHC class II antigen presentation 2.46 7.86e-04 6.57e-03 15/72 KIF2C; TUBA4A; KIF15; CENPE; KIF4A; TUBB4B; KIF18A; KIF5B; KIF11; TUBA1B; TUBA1A; TUBA1C; RACGAP1; KIF23; KIF22
R-HSA-174184 Cdc20:Phospho-APC/C mediated degradation of Cyclin A 2.36 2.57e-03 1.87e-02 13/65 CDC20; RPS27A; MAD2L1; CCNA2; PSMC3; CDK1; BUB3; BUB1B; UBB; CDC27; ANAPC11; UBE2C; UBA52
R-HSA-5693538 Homology Directed Repair 2.27 2.69e-03 1.93e-02 14/73 RPS27A; POLQ; WHSC1; CCNA2; HIST1H4C; RPA3; H2AFX; RHNO1; RAD51AP1; BRCA2; UBB; BRCA1; PCNA; UBA52
R-HSA-5693567 HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) 2.23 4.44e-03 2.94e-02 13/69 RPS27A; WHSC1; CCNA2; HIST1H4C; RPA3; H2AFX; RHNO1; RAD51AP1; BRCA2; UBB; BRCA1; PCNA; UBA52
R-HSA-174178 APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 2.22 6.43e-03 3.90e-02 12/64 CDC20; RPS27A; PTTG1; PSMC3; PLK1; AURKB; UBB; CDC27; ANAPC11; UBE2C; AURKA; UBA52
R-HSA-9018519 Estrogen-dependent gene expression 2.15 8.27e-03 4.88e-02 12/66 HIST2H2AC; H3F3A; H2AFZ; HIST1H4C; HSP90AB1; H2AFV; SMC1A; RAD21; H2AFX; SMC3; KPNA2; H3F3B
R-HSA-1852241 Organelle biogenesis and maintenance 2.11 1.17e-04 1.11e-03 27/151 NEK2; CALM2; TUBA4A; CEP135; SCLT1; TUBB; CEP78; CDK5RAP2; CNTRL; ODF2; WDR34; TUBB4B; CKAP5; CEP57; CDK1; TUBA1B; TUBA1A; TUBA1C; CENPJ; CALM1; CEP152; IDH2; PLK1; TUBG1; HAUS8; CALM3; PCNT
R-HSA-5693532 DNA Double-Strand Break Repair 2.04 5.57e-03 3.47e-02 15/87 RPS27A; POLQ; WHSC1; CCNA2; HIST1H4C; RPA3; H2AFX; RHNO1; RAD51AP1; BRCA2; UBB; BRCA1; KPNA2; PCNA; UBA52
Factor 3 : 223 significant Reactome pathways
GeneSet description enrichRatio pValue FDR GeneRatio geneSymbols
R-HSA-389960 Formation of tubulin folding intermediates by CCT/TriC 12.80 2.01e-09 1.28e-08 9/13 CCT3; CCT4; CCT7; CCT5; TUBB4B; TUBA1B; TUBA1A; CCT2; CCT8
R-HSA-156902 Peptide chain elongation 10.90 0.00e+00 0.00e+00 50/85 RPS8; RPS27; RPS27A; RPL31; RPL37A; RPL32; RPL29; RPL34; RPS3A; RPL37; RPS23; RPS14; RPS18; RPS12; RPS4X; RPL10; RPS20; RPL30; RPL8; RPS6; RPL35; RPL12; RPLP2; RPL27A; RPS13; RPS3; RPL41; RPLP0; RPL21; RPS29; RPLP1; RPS17; RPS2; RPL13; RPL26; RPL23A; RPL19; RPL27; RPL38; RPS21; RPS15; RPL36; RPS28; RPL18A; RPS16; RPS19; RPL18; RPL13A; RPL28; RPL3
R-HSA-192823 Viral mRNA Translation 10.90 0.00e+00 0.00e+00 50/85 RPS8; RPS27; RPS27A; RPL31; RPL37A; RPL32; RPL29; RPL34; RPS3A; RPL37; RPS23; RPS14; RPS18; RPS12; RPS4X; RPL10; RPS20; RPL30; RPL8; RPS6; RPL35; RPL12; RPLP2; RPL27A; RPS13; RPS3; RPL41; RPLP0; RPL21; RPS29; RPLP1; RPS17; RPS2; RPL13; RPL26; RPL23A; RPL19; RPL27; RPL38; RPS21; RPS15; RPL36; RPS28; RPL18A; RPS16; RPS19; RPL18; RPL13A; RPL28; RPL3
R-HSA-2408557 Selenocysteine synthesis 10.90 0.00e+00 0.00e+00 50/85 RPS8; RPS27; RPS27A; RPL31; RPL37A; RPL32; RPL29; RPL34; RPS3A; RPL37; RPS23; RPS14; RPS18; RPS12; RPS4X; RPL10; RPS20; RPL30; RPL8; RPS6; RPL35; RPL12; RPLP2; RPL27A; RPS13; RPS3; RPL41; RPLP0; RPL21; RPS29; RPLP1; RPS17; RPS2; RPL13; RPL26; RPL23A; RPL19; RPL27; RPL38; RPS21; RPS15; RPL36; RPS28; RPL18A; RPS16; RPS19; RPL18; RPL13A; RPL28; RPL3
R-HSA-156842 Eukaryotic Translation Elongation 10.60 0.00e+00 0.00e+00 50/87 RPS8; RPS27; RPS27A; RPL31; RPL37A; RPL32; RPL29; RPL34; RPS3A; RPL37; RPS23; RPS14; RPS18; RPS12; RPS4X; RPL10; RPS20; RPL30; RPL8; RPS6; RPL35; RPL12; RPLP2; RPL27A; RPS13; RPS3; RPL41; RPLP0; RPL21; RPS29; RPLP1; RPS17; RPS2; RPL13; RPL26; RPL23A; RPL19; RPL27; RPL38; RPS21; RPS15; RPL36; RPS28; RPL18A; RPS16; RPS19; RPL18; RPL13A; RPL28; RPL3
R-HSA-72764 Eukaryotic Translation Termination 10.50 0.00e+00 0.00e+00 50/88 RPS8; RPS27; RPS27A; RPL31; RPL37A; RPL32; RPL29; RPL34; RPS3A; RPL37; RPS23; RPS14; RPS18; RPS12; RPS4X; RPL10; RPS20; RPL30; RPL8; RPS6; RPL35; RPL12; RPLP2; RPL27A; RPS13; RPS3; RPL41; RPLP0; RPL21; RPS29; RPLP1; RPS17; RPS2; RPL13; RPL26; RPL23A; RPL19; RPL27; RPL38; RPS21; RPS15; RPL36; RPS28; RPL18A; RPS16; RPS19; RPL18; RPL13A; RPL28; RPL3
R-HSA-975956 Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) 10.40 0.00e+00 0.00e+00 50/89 RPS8; RPS27; RPS27A; RPL31; RPL37A; RPL32; RPL29; RPL34; RPS3A; RPL37; RPS23; RPS14; RPS18; RPS12; RPS4X; RPL10; RPS20; RPL30; RPL8; RPS6; RPL35; RPL12; RPLP2; RPL27A; RPS13; RPS3; RPL41; RPLP0; RPL21; RPS29; RPLP1; RPS17; RPS2; RPL13; RPL26; RPL23A; RPL19; RPL27; RPL38; RPS21; RPS15; RPL36; RPS28; RPL18A; RPS16; RPS19; RPL18; RPL13A; RPL28; RPL3
R-HSA-72689 Formation of a pool of free 40S subunits 9.80 0.00e+00 0.00e+00 51/96 EIF3I; RPS8; RPS27; RPS27A; RPL31; RPL37A; RPL32; RPL29; RPL34; RPS3A; RPL37; RPS23; RPS14; RPS18; RPS12; RPS4X; RPL10; RPS20; RPL30; RPL8; RPS6; RPL35; RPL12; RPLP2; RPL27A; RPS13; RPS3; RPL41; RPLP0; RPL21; RPS29; RPLP1; RPS17; RPS2; RPL13; RPL26; RPL23A; RPL19; RPL27; RPL38; RPS21; RPS15; RPL36; RPS28; RPL18A; RPS16; RPS19; RPL18; RPL13A; RPL28; RPL3
R-HSA-2408522 Selenoamino acid metabolism 9.32 0.00e+00 0.00e+00 50/99 RPS8; RPS27; RPS27A; RPL31; RPL37A; RPL32; RPL29; RPL34; RPS3A; RPL37; RPS23; RPS14; RPS18; RPS12; RPS4X; RPL10; RPS20; RPL30; RPL8; RPS6; RPL35; RPL12; RPLP2; RPL27A; RPS13; RPS3; RPL41; RPLP0; RPL21; RPS29; RPLP1; RPS17; RPS2; RPL13; RPL26; RPL23A; RPL19; RPL27; RPL38; RPS21; RPS15; RPL36; RPS28; RPL18A; RPS16; RPS19; RPL18; RPL13A; RPL28; RPL3
R-HSA-389958 Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding 9.22 2.02e-08 1.20e-07 10/20 CCT3; CCT4; CCT7; CCT5; ACTB; TUBB4B; TUBA1B; TUBA1A; CCT2; CCT8
R-HSA-9010553 Regulation of expression of SLITs and ROBOs 9.16 0.00e+00 0.00e+00 73/147 PSMB2; RPS8; MAGOH; PSMA5; PSMD4; RPS27; RPS27A; RPL31; RPL37A; RPL32; RPL29; RPL34; RPS3A; RPL37; RPS23; RPS14; PSMB8; PSMB9; RPS18; RPS12; PSMB1; PSMA2; PSMC2; RPS4X; RPL10; RPS20; RPL30; RPL8; RPS6; PSMB7; RPL35; RPL12; PSMD13; RPLP2; RPL27A; PSMA1; RPS13; RPS3; RPL41; RPLP0; UBC; RPL21; PSME1; PSME2; RPS29; PSMA3; RPLP1; PSMA4; RPS17; RPS2; RPL13; PSMB6; RPL26; UBB; RPL23A; PSMB3; RPL19; RPL27; RPL38; EIF4A3; RPS21; RPS15; RPL36; RPS28; RPL18A; PSMD8; RPS16; PSMC4; RPS19; RPL18; RPL13A; RPL28; RPL3
R-HSA-1799339 SRP-dependent cotranslational protein targeting to membrane 9.14 0.00e+00 0.00e+00 53/107 RPS8; RPS27; RPS27A; RPL31; RPL37A; RPL32; RPL29; SPCS1; RPL34; RPS3A; RPL37; RPS23; RPS14; RPS18; RPS12; RPS4X; RPL10; RPS20; RPL30; RPL8; RPS6; RPL35; RPL12; RPLP2; RPL27A; RPS13; SPCS2; RPS3; RPL41; RPLP0; RPL21; RPS29; RPLP1; RPS17; RPS2; RPL13; RPL26; RPL23A; RPL19; RPL27; RPL38; RPN2; RPS21; RPS15; RPL36; RPS28; RPL18A; RPS16; RPS19; RPL18; RPL13A; RPL28; RPL3
R-HSA-927802 Nonsense-Mediated Decay (NMD) 9.05 0.00e+00 0.00e+00 52/106 RPS8; MAGOH; RPS27; RPS27A; RPL31; RPL37A; RPL32; RPL29; RPL34; RPS3A; RPL37; RPS23; RPS14; RPS18; RPS12; RPS4X; RPL10; RPS20; RPL30; RPL8; RPS6; RPL35; RPL12; RPLP2; RPL27A; RPS13; RPS3; RPL41; RPLP0; RPL21; RPS29; RPLP1; RPS17; RPS2; RPL13; RPL26; RPL23A; RPL19; RPL27; RPL38; EIF4A3; RPS21; RPS15; RPL36; RPS28; RPL18A; RPS16; RPS19; RPL18; RPL13A; RPL28; RPL3
R-HSA-975957 Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) 9.05 0.00e+00 0.00e+00 52/106 RPS8; MAGOH; RPS27; RPS27A; RPL31; RPL37A; RPL32; RPL29; RPL34; RPS3A; RPL37; RPS23; RPS14; RPS18; RPS12; RPS4X; RPL10; RPS20; RPL30; RPL8; RPS6; RPL35; RPL12; RPLP2; RPL27A; RPS13; RPS3; RPL41; RPLP0; RPL21; RPS29; RPLP1; RPS17; RPS2; RPL13; RPL26; RPL23A; RPL19; RPL27; RPL38; EIF4A3; RPS21; RPS15; RPL36; RPS28; RPL18A; RPS16; RPS19; RPL18; RPL13A; RPL28; RPL3
R-HSA-180534 Vpu mediated degradation of CD4 9.03 0.00e+00 0.00e+00 23/47 PSMB2; PSMA5; PSMD4; RPS27A; SKP1; PSMB8; PSMB9; PSMB1; PSMA2; PSMC2; PSMB7; PSMD13; PSMA1; UBC; PSME1; PSME2; PSMA3; PSMA4; PSMB6; UBB; PSMB3; PSMD8; PSMC4
R-HSA-8852276 The role of GTSE1 in G2/M progression after G2 checkpoint 8.92 0.00e+00 0.00e+00 29/60 PSMB2; PSMA5; PSMD4; RPS27A; CCNB1; PSMB8; PSMB9; HSP90AB1; PSMB1; PSMA2; PSMC2; PSMB7; TUBB4B; PSMD13; PSMA1; TUBA1B; TUBA1A; UBC; PSME1; PSME2; PSMA3; HSP90AA1; CCNB2; PSMA4; PSMB6; UBB; PSMB3; PSMD8; PSMC4
R-HSA-156827 L13a-mediated translational silencing of Ceruloplasmin expression 8.88 0.00e+00 0.00e+00 51/106 EIF3I; RPS8; RPS27; RPS27A; RPL31; RPL37A; RPL32; RPL29; RPL34; RPS3A; RPL37; RPS23; RPS14; RPS18; RPS12; RPS4X; RPL10; RPS20; RPL30; RPL8; RPS6; RPL35; RPL12; RPLP2; RPL27A; RPS13; RPS3; RPL41; RPLP0; RPL21; RPS29; RPLP1; RPS17; RPS2; RPL13; RPL26; RPL23A; RPL19; RPL27; RPL38; RPS21; RPS15; RPL36; RPS28; RPL18A; RPS16; RPS19; RPL18; RPL13A; RPL28; RPL3
R-HSA-72706 GTP hydrolysis and joining of the 60S ribosomal subunit 8.79 0.00e+00 0.00e+00 51/107 EIF3I; RPS8; RPS27; RPS27A; RPL31; RPL37A; RPL32; RPL29; RPL34; RPS3A; RPL37; RPS23; RPS14; RPS18; RPS12; RPS4X; RPL10; RPS20; RPL30; RPL8; RPS6; RPL35; RPL12; RPLP2; RPL27A; RPS13; RPS3; RPL41; RPLP0; RPL21; RPS29; RPLP1; RPS17; RPS2; RPL13; RPL26; RPL23A; RPL19; RPL27; RPL38; RPS21; RPS15; RPL36; RPS28; RPL18A; RPS16; RPS19; RPL18; RPL13A; RPL28; RPL3
R-HSA-389957 Prefoldin mediated transfer of substrate to CCT/TriC 8.74 1.95e-07 1.10e-06 9/19 CCT3; CCT4; CCT7; CCT5; ACTB; TUBB4B; TUBA1A; CCT2; CCT8
R-HSA-211733 Regulation of activated PAK-2p34 by proteasome mediated degradation 8.64 2.22e-16 4.68e-15 22/47 PSMB2; PSMA5; PSMD4; RPS27A; PSMB8; PSMB9; PSMB1; PSMA2; PSMC2; PSMB7; PSMD13; PSMA1; UBC; PSME1; PSME2; PSMA3; PSMA4; PSMB6; UBB; PSMB3; PSMD8; PSMC4
R-HSA-174113 SCF-beta-TrCP mediated degradation of Emi1 8.49 0.00e+00 0.00e+00 23/50 PSMB2; PSMA5; PSMD4; RPS27A; SKP1; PSMB8; PSMB9; PSMB1; PSMA2; PSMC2; PSMB7; PSMD13; PSMA1; UBC; PSME1; PSME2; PSMA3; PSMA4; PSMB6; UBB; PSMB3; PSMD8; PSMC4
R-HSA-8854050 FBXL7 down-regulates AURKA during mitotic entry and in early mitosis 8.49 0.00e+00 0.00e+00 23/50 PSMB2; PSMA5; PSMD4; RPS27A; SKP1; PSMB8; PSMB9; PSMB1; PSMA2; PSMC2; PSMB7; PSMD13; PSMA1; UBC; PSME1; PSME2; PSMA3; PSMA4; PSMB6; UBB; PSMB3; PSMD8; PSMC4
R-HSA-69229 Ubiquitin-dependent degradation of Cyclin D1 8.46 4.44e-16 7.42e-15 22/48 PSMB2; PSMA5; PSMD4; RPS27A; PSMB8; PSMB9; PSMB1; PSMA2; PSMC2; PSMB7; PSMD13; PSMA1; UBC; PSME1; PSME2; PSMA3; PSMA4; PSMB6; UBB; PSMB3; PSMD8; PSMC4
R-HSA-75815 Ubiquitin-dependent degradation of Cyclin D 8.46 4.44e-16 7.42e-15 22/48 PSMB2; PSMA5; PSMD4; RPS27A; PSMB8; PSMB9; PSMB1; PSMA2; PSMC2; PSMB7; PSMD13; PSMA1; UBC; PSME1; PSME2; PSMA3; PSMA4; PSMB6; UBB; PSMB3; PSMD8; PSMC4
R-HSA-4608870 Asymmetric localization of PCP proteins 8.46 4.44e-16 7.42e-15 22/48 PSMB2; PSMA5; PSMD4; RPS27A; PSMB8; PSMB9; PSMB1; PSMA2; PSMC2; PSMB7; PSMD13; PSMA1; UBC; PSME1; PSME2; PSMA3; PSMA4; PSMB6; UBB; PSMB3; PSMD8; PSMC4
R-HSA-4641257 Degradation of AXIN 8.46 4.44e-16 7.42e-15 22/48 PSMB2; PSMA5; PSMD4; RPS27A; PSMB8; PSMB9; PSMB1; PSMA2; PSMC2; PSMB7; PSMD13; PSMA1; UBC; PSME1; PSME2; PSMA3; PSMA4; PSMB6; UBB; PSMB3; PSMD8; PSMC4
R-HSA-69601 Ubiquitin Mediated Degradation of Phosphorylated Cdc25A 8.46 4.44e-16 7.42e-15 22/48 PSMB2; PSMA5; PSMD4; RPS27A; PSMB8; PSMB9; PSMB1; PSMA2; PSMC2; PSMB7; PSMD13; PSMA1; UBC; PSME1; PSME2; PSMA3; PSMA4; PSMB6; UBB; PSMB3; PSMD8; PSMC4
R-HSA-69610 p53-Independent DNA Damage Response 8.46 4.44e-16 7.42e-15 22/48 PSMB2; PSMA5; PSMD4; RPS27A; PSMB8; PSMB9; PSMB1; PSMA2; PSMC2; PSMB7; PSMD13; PSMA1; UBC; PSME1; PSME2; PSMA3; PSMA4; PSMB6; UBB; PSMB3; PSMD8; PSMC4
R-HSA-69613 p53-Independent G1/S DNA damage checkpoint 8.46 4.44e-16 7.42e-15 22/48 PSMB2; PSMA5; PSMD4; RPS27A; PSMB8; PSMB9; PSMB1; PSMA2; PSMC2; PSMB7; PSMD13; PSMA1; UBC; PSME1; PSME2; PSMA3; PSMA4; PSMB6; UBB; PSMB3; PSMD8; PSMC4
R-HSA-72695 Formation of the ternary complex, and subsequently, the 43S complex 8.46 4.44e-16 7.42e-15 22/48 EIF3I; RPS8; RPS27; RPS27A; RPS3A; RPS23; RPS14; RPS18; RPS12; RPS4X; RPS20; RPS6; RPS13; RPS3; RPS29; RPS17; RPS2; RPS21; RPS15; RPS28; RPS16; RPS19
R-HSA-1236978 Cross-presentation of soluble exogenous antigens (endosomes) 8.35 5.77e-14 5.56e-13 19/42 PSMB2; PSMA5; PSMD4; PSMB8; PSMB9; PSMB1; PSMA2; PSMC2; PSMB7; PSMD13; PSMA1; PSME1; PSME2; PSMA3; PSMA4; PSMB6; PSMB3; PSMD8; PSMC4
R-HSA-5610780 Degradation of GLI1 by the proteasome 8.32 1.11e-16 2.73e-15 23/51 PSMB2; PSMA5; PSMD4; RPS27A; SKP1; PSMB8; PSMB9; PSMB1; PSMA2; PSMC2; PSMB7; PSMD13; PSMA1; UBC; PSME1; PSME2; PSMA3; PSMA4; PSMB6; UBB; PSMB3; PSMD8; PSMC4
R-HSA-169911 Regulation of Apoptosis 8.28 6.66e-16 1.05e-14 22/49 PSMB2; PSMA5; PSMD4; RPS27A; PSMB8; PSMB9; PSMB1; PSMA2; PSMC2; PSMB7; PSMD13; PSMA1; UBC; PSME1; PSME2; PSMA3; PSMA4; PSMB6; UBB; PSMB3; PSMD8; PSMC4
R-HSA-349425 Autodegradation of the E3 ubiquitin ligase COP1 8.28 6.66e-16 1.05e-14 22/49 PSMB2; PSMA5; PSMD4; RPS27A; PSMB8; PSMB9; PSMB1; PSMA2; PSMC2; PSMB7; PSMD13; PSMA1; UBC; PSME1; PSME2; PSMA3; PSMA4; PSMB6; UBB; PSMB3; PSMD8; PSMC4
R-HSA-4641258 Degradation of DVL 8.28 6.66e-16 1.05e-14 22/49 PSMB2; PSMA5; PSMD4; RPS27A; PSMB8; PSMB9; PSMB1; PSMA2; PSMC2; PSMB7; PSMD13; PSMA1; UBC; PSME1; PSME2; PSMA3; PSMA4; PSMB6; UBB; PSMB3; PSMD8; PSMC4
R-HSA-72613 Eukaryotic Translation Initiation 8.25 0.00e+00 0.00e+00 51/114 EIF3I; RPS8; RPS27; RPS27A; RPL31; RPL37A; RPL32; RPL29; RPL34; RPS3A; RPL37; RPS23; RPS14; RPS18; RPS12; RPS4X; RPL10; RPS20; RPL30; RPL8; RPS6; RPL35; RPL12; RPLP2; RPL27A; RPS13; RPS3; RPL41; RPLP0; RPL21; RPS29; RPLP1; RPS17; RPS2; RPL13; RPL26; RPL23A; RPL19; RPL27; RPL38; RPS21; RPS15; RPL36; RPS28; RPL18A; RPS16; RPS19; RPL18; RPL13A; RPL28; RPL3
R-HSA-72737 Cap-dependent Translation Initiation 8.25 0.00e+00 0.00e+00 51/114 EIF3I; RPS8; RPS27; RPS27A; RPL31; RPL37A; RPL32; RPL29; RPL34; RPS3A; RPL37; RPS23; RPS14; RPS18; RPS12; RPS4X; RPL10; RPS20; RPL30; RPL8; RPS6; RPL35; RPL12; RPLP2; RPL27A; RPS13; RPS3; RPL41; RPLP0; RPL21; RPS29; RPLP1; RPS17; RPS2; RPL13; RPL26; RPL23A; RPL19; RPL27; RPL38; RPS21; RPS15; RPL36; RPS28; RPL18A; RPS16; RPS19; RPL18; RPL13A; RPL28; RPL3
R-HSA-376176 Signaling by ROBO receptors 8.17 0.00e+00 0.00e+00 74/167 PSMB2; CAP1; RPS8; MAGOH; PSMA5; PSMD4; RPS27; RPS27A; RPL31; RPL37A; RPL32; RPL29; RPL34; RPS3A; RPL37; RPS23; RPS14; PSMB8; PSMB9; RPS18; RPS12; PSMB1; PSMA2; PSMC2; RPS4X; RPL10; RPS20; RPL30; RPL8; RPS6; PSMB7; RPL35; RPL12; PSMD13; RPLP2; RPL27A; PSMA1; RPS13; RPS3; RPL41; RPLP0; UBC; RPL21; PSME1; PSME2; RPS29; PSMA3; RPLP1; PSMA4; RPS17; RPS2; RPL13; PSMB6; RPL26; UBB; RPL23A; PSMB3; RPL19; RPL27; RPL38; EIF4A3; RPS21; RPS15; RPL36; RPS28; RPL18A; PSMD8; RPS16; PSMC4; RPS19; RPL18; RPL13A; RPL28; RPL3
R-HSA-450408 AUF1 (hnRNP D0) binds and destabilizes mRNA 8.16 2.22e-16 4.68e-15 23/52 PSMB2; PSMA5; PSMD4; RPS27A; PSMB8; PSMB9; PSMB1; PSMA2; PSMC2; PSMB7; PSMD13; PSMA1; HSPA8; UBC; PSME1; PSME2; PSMA3; PSMA4; PSMB6; UBB; PSMB3; PSMD8; PSMC4
R-HSA-5610783 Degradation of GLI2 by the proteasome 8.16 2.22e-16 4.68e-15 23/52 PSMB2; PSMA5; PSMD4; RPS27A; SKP1; PSMB8; PSMB9; PSMB1; PSMA2; PSMC2; PSMB7; PSMD13; PSMA1; UBC; PSME1; PSME2; PSMA3; PSMA4; PSMB6; UBB; PSMB3; PSMD8; PSMC4
R-HSA-5610785 GLI3 is processed to GLI3R by the proteasome 8.16 2.22e-16 4.68e-15 23/52 PSMB2; PSMA5; PSMD4; RPS27A; SKP1; PSMB8; PSMB9; PSMB1; PSMA2; PSMC2; PSMB7; PSMD13; PSMA1; UBC; PSME1; PSME2; PSMA3; PSMA4; PSMB6; UBB; PSMB3; PSMD8; PSMC4
R-HSA-5676590 NIK-->noncanonical NF-kB signaling 8.16 2.22e-16 4.68e-15 23/52 PSMB2; PSMA5; PSMD4; RPS27A; SKP1; PSMB8; PSMB9; PSMB1; PSMA2; PSMC2; PSMB7; PSMD13; PSMA1; UBC; PSME1; PSME2; PSMA3; PSMA4; PSMB6; UBB; PSMB3; PSMD8; PSMC4
R-HSA-9604323 Negative regulation of NOTCH4 signaling 8.16 2.22e-16 4.68e-15 23/52 PSMB2; PSMA5; PSMD4; RPS27A; SKP1; PSMB8; PSMB9; PSMB1; PSMA2; PSMC2; PSMB7; PSMD13; PSMA1; UBC; PSME1; PSME2; PSMA3; PSMA4; PSMB6; UBB; PSMB3; PSMD8; PSMC4
R-HSA-5626467 RHO GTPases activate IQGAPs 8.07 9.35e-06 5.08e-05 7/16 CALM2; CTNNB1; ACTB; TUBB4B; TUBA1B; TUBA1A; ACTG1
R-HSA-187577 SCF(Skp2)-mediated degradation of p27/p21 8.01 3.33e-16 6.71e-15 23/53 PSMB2; PSMA5; PSMD4; RPS27A; SKP1; PSMB8; PSMB9; PSMB1; PSMA2; PSMC2; PSMB7; PSMD13; PSMA1; UBC; PSME1; PSME2; PSMA3; PSMA4; PSMB6; UBB; PSMB3; PSMD8; PSMC4
R-HSA-5607761 Dectin-1 mediated noncanonical NF-kB signaling 8.01 3.33e-16 6.71e-15 23/53 PSMB2; PSMA5; PSMD4; RPS27A; SKP1; PSMB8; PSMB9; PSMB1; PSMA2; PSMC2; PSMB7; PSMD13; PSMA1; UBC; PSME1; PSME2; PSMA3; PSMA4; PSMB6; UBB; PSMB3; PSMD8; PSMC4
R-HSA-180585 Vif-mediated degradation of APOBEC3G 7.96 1.78e-15 2.62e-14 22/51 PSMB2; PSMA5; PSMD4; RPS27A; PSMB8; PSMB9; PSMB1; PSMA2; PSMC2; PSMB7; PSMD13; PSMA1; UBC; PSME1; PSME2; PSMA3; PSMA4; PSMB6; UBB; PSMB3; PSMD8; PSMC4
R-HSA-5362768 Hh mutants that don't undergo autocatalytic processing are degraded by ERAD 7.96 1.78e-15 2.62e-14 22/51 PSMB2; PSMA5; PSMD4; RPS27A; PSMB8; PSMB9; PSMB1; PSMA2; PSMC2; PSMB7; PSMD13; PSMA1; UBC; PSME1; PSME2; PSMA3; PSMA4; PSMB6; UBB; PSMB3; PSMD8; PSMC4
R-HSA-5387390 Hh mutants abrogate ligand secretion 7.96 1.78e-15 2.62e-14 22/51 PSMB2; PSMA5; PSMD4; RPS27A; PSMB8; PSMB9; PSMB1; PSMA2; PSMC2; PSMB7; PSMD13; PSMA1; UBC; PSME1; PSME2; PSMA3; PSMA4; PSMB6; UBB; PSMB3; PSMD8; PSMC4
R-HSA-8941858 Regulation of RUNX3 expression and activity 7.96 1.78e-15 2.62e-14 22/51 PSMB2; PSMA5; PSMD4; RPS27A; PSMB8; PSMB9; PSMB1; PSMA2; PSMC2; PSMB7; PSMD13; PSMA1; UBC; PSME1; PSME2; PSMA3; PSMA4; PSMB6; UBB; PSMB3; PSMD8; PSMC4
R-HSA-168273 Influenza Viral RNA Transcription and Replication 7.93 0.00e+00 0.00e+00 52/121 RPS8; RPS27; RPS27A; RPL31; RPL37A; RPL32; RPL29; RPL34; RPS3A; RPL37; RPS23; RPS14; RPS18; RPS12; RPS4X; RPL10; RPS20; RPL30; RPL8; RPS6; RPL35; RPL12; RPLP2; RPL27A; RPS13; POLR2G; RPS3; RPL41; RPLP0; RPL21; RPS29; HSP90AA1; RPLP1; RPS17; RPS2; RPL13; RPL26; RPL23A; RPL19; RPL27; RPL38; RPS21; RPS15; RPL36; RPS28; RPL18A; RPS16; RPS19; RPL18; RPL13A; RPL28; RPL3
R-HSA-5358346 Hedgehog ligand biogenesis 7.81 3.00e-15 4.28e-14 22/52 PSMB2; PSMA5; PSMD4; RPS27A; PSMB8; PSMB9; PSMB1; PSMA2; PSMC2; PSMB7; PSMD13; PSMA1; UBC; PSME1; PSME2; PSMA3; PSMA4; PSMB6; UBB; PSMB3; PSMD8; PSMC4
R-HSA-157858 Gap junction trafficking and regulation 7.69 2.58e-04 1.30e-03 5/12 ACTB; TUBB4B; TUBA1B; TUBA1A; ACTG1
R-HSA-190828 Gap junction trafficking 7.69 2.58e-04 1.30e-03 5/12 ACTB; TUBB4B; TUBA1B; TUBA1A; ACTG1
R-HSA-5658442 Regulation of RAS by GAPs 7.66 4.88e-15 6.46e-14 22/53 PSMB2; PSMA5; PSMD4; RPS27A; PSMB8; PSMB9; PSMB1; PSMA2; PSMC2; PSMB7; PSMD13; PSMA1; UBC; PSME1; PSME2; PSMA3; PSMA4; PSMB6; UBB; PSMB3; PSMD8; PSMC4
R-HSA-5678895 Defective CFTR causes cystic fibrosis 7.66 4.88e-15 6.46e-14 22/53 PSMB2; PSMA5; PSMD4; RPS27A; PSMB8; PSMB9; PSMB1; PSMA2; PSMC2; PSMB7; PSMD13; PSMA1; UBC; PSME1; PSME2; PSMA3; PSMA4; PSMB6; UBB; PSMB3; PSMD8; PSMC4
R-HSA-68827 CDT1 association with the CDC6:ORC:origin complex 7.66 4.88e-15 6.46e-14 22/53 PSMB2; PSMA5; PSMD4; RPS27A; PSMB8; PSMB9; PSMB1; PSMA2; PSMC2; PSMB7; PSMD13; PSMA1; UBC; PSME1; PSME2; PSMA3; PSMA4; PSMB6; UBB; PSMB3; PSMD8; PSMC4
R-HSA-69541 Stabilization of p53 7.66 4.88e-15 6.46e-14 22/53 PSMB2; PSMA5; PSMD4; RPS27A; PSMB8; PSMB9; PSMB1; PSMA2; PSMC2; PSMB7; PSMD13; PSMA1; UBC; PSME1; PSME2; PSMA3; PSMA4; PSMB6; UBB; PSMB3; PSMD8; PSMC4
R-HSA-350562 Regulation of ornithine decarboxylase (ODC) 7.62 4.43e-13 3.63e-12 19/46 PSMB2; PSMA5; PSMD4; PSMB8; PSMB9; PSMB1; PSMA2; PSMC2; PSMB7; PSMD13; PSMA1; PSME1; PSME2; PSMA3; PSMA4; PSMB6; PSMB3; PSMD8; PSMC4
R-HSA-70263 Gluconeogenesis 7.60 1.52e-05 8.15e-05 7/17 ENO1; MDH1; PGK1; PGAM1; GAPDH; TPI1; ALDOA
R-HSA-168255 Influenza Life Cycle 7.52 0.00e+00 0.00e+00 53/130 RPS8; RPS27; RPS27A; RPL31; RPL37A; RPL32; RPL29; RPL34; RPS3A; RPL37; RPS23; RPS14; RPS18; RPS12; RPS4X; RPL10; RPS20; RPL30; RPL8; RPS6; RPL35; RPL12; RPLP2; RPL27A; RPS13; POLR2G; RPS3; RPL41; RPLP0; RAN; RPL21; RPS29; HSP90AA1; RPLP1; RPS17; RPS2; RPL13; RPL26; RPL23A; RPL19; RPL27; RPL38; RPS21; RPS15; RPL36; RPS28; RPL18A; RPS16; RPS19; RPL18; RPL13A; RPL28; RPL3
R-HSA-5619084 ABC transporter disorders 7.52 7.88e-15 9.98e-14 22/54 PSMB2; PSMA5; PSMD4; RPS27A; PSMB8; PSMB9; PSMB1; PSMA2; PSMC2; PSMB7; PSMD13; PSMA1; UBC; PSME1; PSME2; PSMA3; PSMA4; PSMB6; UBB; PSMB3; PSMD8; PSMC4
R-HSA-72649 Translation initiation complex formation 7.38 1.24e-14 1.47e-13 22/55 EIF3I; RPS8; RPS27; RPS27A; RPS3A; RPS23; RPS14; RPS18; RPS12; RPS4X; RPS20; RPS6; RPS13; RPS3; RPS29; RPS17; RPS2; RPS21; RPS15; RPS28; RPS16; RPS19
R-HSA-72702 Ribosomal scanning and start codon recognition 7.38 1.24e-14 1.47e-13 22/55 EIF3I; RPS8; RPS27; RPS27A; RPS3A; RPS23; RPS14; RPS18; RPS12; RPS4X; RPS20; RPS6; RPS13; RPS3; RPS29; RPS17; RPS2; RPS21; RPS15; RPS28; RPS16; RPS19
R-HSA-1236974 ER-Phagosome pathway 7.33 0.00e+00 0.00e+00 27/68 PSMB2; PSMA5; PSMD4; RPS27A; HLA-A; HLA-C; HLA-B; PSMB8; PSMB9; PSMB1; PSMA2; PSMC2; PSMB7; PSMD13; PSMA1; UBC; PSME1; PSME2; PSMA3; PDIA3; B2M; PSMA4; PSMB6; UBB; PSMB3; PSMD8; PSMC4
R-HSA-8939902 Regulation of RUNX2 expression and activity 7.32 3.77e-15 5.31e-14 23/58 PSMB2; PSMA5; PSMD4; RPS27A; SKP1; PSMB8; PSMB9; PSMB1; PSMA2; PSMC2; PSMB7; PSMD13; PSMA1; UBC; PSME1; PSME2; PSMA3; PSMA4; PSMB6; UBB; PSMB3; PSMD8; PSMC4
R-HSA-5610787 Hedgehog 'off' state 7.27 0.00e+00 0.00e+00 26/66 PSMB2; PSMA5; PSMD4; RPS27A; SKP1; PSMB8; PSMB9; PSMB1; PSMA2; PSMC2; PSMB7; TUBB4B; PSMD13; PSMA1; TUBA1B; TUBA1A; UBC; PSME1; PSME2; PSMA3; PSMA4; PSMB6; UBB; PSMB3; PSMD8; PSMC4
R-HSA-5632684 Hedgehog 'on' state 7.25 1.97e-14 2.23e-13 22/56 PSMB2; PSMA5; PSMD4; RPS27A; PSMB8; PSMB9; PSMB1; PSMA2; PSMC2; PSMB7; PSMD13; PSMA1; UBC; PSME1; PSME2; PSMA3; PSMA4; PSMB6; UBB; PSMB3; PSMD8; PSMC4
R-HSA-72662 Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S 7.25 1.97e-14 2.23e-13 22/56 EIF3I; RPS8; RPS27; RPS27A; RPS3A; RPS23; RPS14; RPS18; RPS12; RPS4X; RPS20; RPS6; RPS13; RPS3; RPS29; RPS17; RPS2; RPS21; RPS15; RPS28; RPS16; RPS19
R-HSA-1236975 Antigen processing-Cross presentation 7.17 0.00e+00 0.00e+00 28/72 PSMB2; PSMA5; PSMD4; RPS27A; HLA-A; HLA-C; HLA-B; PSMB8; PSMB9; PSMB1; PSMA2; PSMC2; PSMB7; PSMD13; PSMA1; UBC; PSME1; PSME2; PSMA3; PDIA3; B2M; PSMA4; CYBA; PSMB6; UBB; PSMB3; PSMD8; PSMC4
R-HSA-8948751 Regulation of PTEN stability and activity 7.12 3.04e-14 3.10e-13 22/57 PSMB2; PSMA5; PSMD4; RPS27A; PSMB8; PSMB9; PSMB1; PSMA2; PSMC2; PSMB7; PSMD13; PSMA1; UBC; PSME1; PSME2; PSMA3; PSMA4; PSMB6; UBB; PSMB3; PSMD8; PSMC4
R-HSA-69563 p53-Dependent G1 DNA Damage Response 7.12 3.04e-14 3.10e-13 22/57 PSMB2; PSMA5; PSMD4; RPS27A; PSMB8; PSMB9; PSMB1; PSMA2; PSMC2; PSMB7; PSMD13; PSMA1; UBC; PSME1; PSME2; PSMA3; PSMA4; PSMB6; UBB; PSMB3; PSMD8; PSMC4
R-HSA-69580 p53-Dependent G1/S DNA damage checkpoint 7.12 3.04e-14 3.10e-13 22/57 PSMB2; PSMA5; PSMD4; RPS27A; PSMB8; PSMB9; PSMB1; PSMA2; PSMC2; PSMB7; PSMD13; PSMA1; UBC; PSME1; PSME2; PSMA3; PSMA4; PSMB6; UBB; PSMB3; PSMD8; PSMC4
R-HSA-1234176 Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha 7.12 3.04e-14 3.10e-13 22/57 PSMB2; PSMA5; PSMD4; RPS27A; PSMB8; PSMB9; PSMB1; PSMA2; PSMC2; PSMB7; PSMD13; PSMA1; UBC; PSME1; PSME2; PSMA3; PSMA4; PSMB6; UBB; PSMB3; PSMD8; PSMC4
R-HSA-195253 Degradation of beta-catenin by the destruction complex 7.10 4.44e-16 7.42e-15 25/65 HDAC1; PSMB2; PSMA5; PSMD4; RPS27A; CTNNB1; SKP1; PSMB8; PSMB9; PSMB1; PSMA2; PSMC2; PSMB7; PSMD13; PSMA1; UBC; PSME1; PSME2; PSMA3; PSMA4; PSMB6; UBB; PSMB3; PSMD8; PSMC4
R-HSA-9013694 Signaling by NOTCH4 7.07 9.10e-15 1.12e-13 23/60 PSMB2; PSMA5; PSMD4; RPS27A; SKP1; PSMB8; PSMB9; PSMB1; PSMA2; PSMC2; PSMB7; PSMD13; PSMA1; UBC; PSME1; PSME2; PSMA3; PSMA4; PSMB6; UBB; PSMB3; PSMD8; PSMC4
R-HSA-1169091 Activation of NF-kappaB in B cells 7.07 9.10e-15 1.12e-13 23/60 PSMB2; PSMA5; PSMD4; RPS27A; SKP1; PSMB8; PSMB9; PSMB1; PSMA2; PSMC2; PSMB7; PSMD13; PSMA1; UBC; PSME1; PSME2; PSMA3; PSMA4; PSMB6; UBB; PSMB3; PSMD8; PSMC4
R-HSA-168254 Influenza Infection 7.03 0.00e+00 0.00e+00 53/139 RPS8; RPS27; RPS27A; RPL31; RPL37A; RPL32; RPL29; RPL34; RPS3A; RPL37; RPS23; RPS14; RPS18; RPS12; RPS4X; RPL10; RPS20; RPL30; RPL8; RPS6; RPL35; RPL12; RPLP2; RPL27A; RPS13; POLR2G; RPS3; RPL41; RPLP0; RAN; RPL21; RPS29; HSP90AA1; RPLP1; RPS17; RPS2; RPL13; RPL26; RPL23A; RPL19; RPL27; RPL38; RPS21; RPS15; RPL36; RPS28; RPL18A; RPS16; RPS19; RPL18; RPL13A; RPL28; RPL3
R-HSA-68949 Orc1 removal from chromatin 7.03 2.66e-15 3.87e-14 24/63 PSMB2; PSMA5; PSMD4; RPS27A; SKP1; PSMB8; PSMB9; PSMB1; PSMA2; MCM7; PSMC2; PSMB7; PSMD13; PSMA1; UBC; PSME1; PSME2; PSMA3; PSMA4; PSMB6; UBB; PSMB3; PSMD8; PSMC4
R-HSA-69615 G1/S DNA Damage Checkpoints 7.00 4.69e-14 4.58e-13 22/58 PSMB2; PSMA5; PSMD4; RPS27A; PSMB8; PSMB9; PSMB1; PSMA2; PSMC2; PSMB7; PSMD13; PSMA1; UBC; PSME1; PSME2; PSMA3; PSMA4; PSMB6; UBB; PSMB3; PSMD8; PSMC4
R-HSA-174084 Autodegradation of Cdh1 by Cdh1:APC/C 7.00 4.69e-14 4.58e-13 22/58 PSMB2; PSMA5; PSMD4; RPS27A; PSMB8; PSMB9; PSMB1; PSMA2; PSMC2; PSMB7; PSMD13; PSMA1; UBC; PSME1; PSME2; PSMA3; PSMA4; PSMB6; UBB; PSMB3; PSMD8; PSMC4
R-HSA-68867 Assembly of the pre-replicative complex 6.84 2.11e-14 2.34e-13 23/62 PSMB2; PSMA5; PSMD4; RPS27A; PSMB8; PSMB9; PSMB1; PSMA2; MCM7; PSMC2; PSMB7; PSMD13; PSMA1; UBC; PSME1; PSME2; PSMA3; PSMA4; PSMB6; UBB; PSMB3; PSMD8; PSMC4
R-HSA-382556 ABC-family proteins mediated transport 6.76 1.07e-13 9.68e-13 22/60 PSMB2; PSMA5; PSMD4; RPS27A; PSMB8; PSMB9; PSMB1; PSMA2; PSMC2; PSMB7; PSMD13; PSMA1; UBC; PSME1; PSME2; PSMA3; PSMA4; PSMB6; UBB; PSMB3; PSMD8; PSMC4
R-HSA-5619115 Disorders of transmembrane transporters 6.76 1.07e-13 9.68e-13 22/60 PSMB2; PSMA5; PSMD4; RPS27A; PSMB8; PSMB9; PSMB1; PSMA2; PSMC2; PSMB7; PSMD13; PSMA1; UBC; PSME1; PSME2; PSMA3; PSMA4; PSMB6; UBB; PSMB3; PSMD8; PSMC4
R-HSA-9013507 NOTCH3 Activation and Transmission of Signal to the Nucleus 6.71 2.05e-03 9.49e-03 4/11 YBX1; RPS27A; UBC; UBB
R-HSA-5663084 Diseases of carbohydrate metabolism 6.71 2.05e-03 9.49e-03 4/11 RPS27A; TALDO1; UBC; UBB
R-HSA-174154 APC/C:Cdc20 mediated degradation of Securin 6.65 1.60e-13 1.43e-12 22/61 PSMB2; PSMA5; PSMD4; RPS27A; PSMB8; PSMB9; PSMB1; PSMA2; PSMC2; PSMB7; PSMD13; PSMA1; UBC; PSME1; PSME2; PSMA3; PSMA4; PSMB6; UBB; PSMB3; PSMD8; PSMC4
R-HSA-8878159 Transcriptional regulation by RUNX3 6.63 4.71e-14 4.58e-13 23/64 PSMB2; PSMA5; PSMD4; RPS27A; CTNNB1; PSMB8; PSMB9; PSMB1; PSMA2; PSMC2; PSMB7; PSMD13; PSMA1; UBC; PSME1; PSME2; PSMA3; PSMA4; PSMB6; UBB; PSMB3; PSMD8; PSMC4
R-HSA-8939236 RUNX1 regulates transcription of genes involved in differentiation of HSCs 6.63 4.71e-14 4.58e-13 23/64 PSMB2; PSMA5; PSMD4; RPS27A; HIST1H4C; PSMB8; PSMB9; PSMB1; PSMA2; PSMC2; PSMB7; PSMD13; PSMA1; UBC; PSME1; PSME2; PSMA3; PSMA4; PSMB6; UBB; PSMB3; PSMD8; PSMC4
R-HSA-174184 Cdc20:Phospho-APC/C mediated degradation of Cyclin A 6.53 6.95e-14 6.55e-13 23/65 PSMB2; PSMA5; PSMD4; RPS27A; MAD2L1; PSMB8; PSMB9; PSMB1; PSMA2; PSMC2; PSMB7; PSMD13; PSMA1; UBC; PSME1; PSME2; PSMA3; PSMA4; PSMB6; UBB; PSMB3; PSMD8; PSMC4
R-HSA-176409 APC/C:Cdc20 mediated degradation of mitotic proteins 6.51 2.04e-14 2.29e-13 24/68 PSMB2; PSMA5; PSMD4; RPS27A; MAD2L1; CCNB1; PSMB8; PSMB9; PSMB1; PSMA2; PSMC2; PSMB7; PSMD13; PSMA1; UBC; PSME1; PSME2; PSMA3; PSMA4; PSMB6; UBB; PSMB3; PSMD8; PSMC4
R-HSA-176408 Regulation of APC/C activators between G1/S and early anaphase 6.50 6.00e-15 7.81e-14 25/71 PSMB2; PSMA5; PSMD4; RPS27A; MAD2L1; CCNB1; SKP1; PSMB8; PSMB9; PSMB1; PSMA2; PSMC2; PSMB7; PSMD13; PSMA1; UBC; PSME1; PSME2; PSMA3; PSMA4; PSMB6; UBB; PSMB3; PSMD8; PSMC4
R-HSA-351202 Metabolism of polyamines 6.47 3.95e-12 2.94e-11 20/57 SRM; PSMB2; PSMA5; PSMD4; PSMB8; PSMB9; PSMB1; PSMA2; PSMC2; PSMB7; PSMD13; PSMA1; PSME1; PSME2; PSMA3; PSMA4; PSMB6; PSMB3; PSMD8; PSMC4
R-HSA-69017 CDK-mediated phosphorylation and removal of Cdc6 6.44 3.45e-13 2.89e-12 22/63 PSMB2; PSMA5; PSMD4; RPS27A; PSMB8; PSMB9; PSMB1; PSMA2; PSMC2; PSMB7; PSMD13; PSMA1; UBC; PSME1; PSME2; PSMA3; PSMA4; PSMB6; UBB; PSMB3; PSMD8; PSMC4
R-HSA-1234174 Regulation of Hypoxia-inducible Factor (HIF) by oxygen 6.44 3.45e-13 2.89e-12 22/63 PSMB2; PSMA5; PSMD4; RPS27A; PSMB8; PSMB9; PSMB1; PSMA2; PSMC2; PSMB7; PSMD13; PSMA1; UBC; PSME1; PSME2; PSMA3; PSMA4; PSMB6; UBB; PSMB3; PSMD8; PSMC4
R-HSA-2262749 Cellular response to hypoxia 6.44 3.45e-13 2.89e-12 22/63 PSMB2; PSMA5; PSMD4; RPS27A; PSMB8; PSMB9; PSMB1; PSMA2; PSMC2; PSMB7; PSMD13; PSMA1; UBC; PSME1; PSME2; PSMA3; PSMA4; PSMB6; UBB; PSMB3; PSMD8; PSMC4
R-HSA-2871837 FCERI mediated NF-kB activation 6.43 1.02e-13 9.38e-13 23/66 PSMB2; PSMA5; PSMD4; RPS27A; SKP1; PSMB8; PSMB9; PSMB1; PSMA2; PSMC2; PSMB7; PSMD13; PSMA1; UBC; PSME1; PSME2; PSMA3; PSMA4; PSMB6; UBB; PSMB3; PSMD8; PSMC4
R-HSA-179419 APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint 6.43 1.02e-13 9.38e-13 23/66 PSMB2; PSMA5; PSMD4; RPS27A; MAD2L1; PSMB8; PSMB9; PSMB1; PSMA2; PSMC2; PSMB7; PSMD13; PSMA1; UBC; PSME1; PSME2; PSMA3; PSMA4; PSMB6; UBB; PSMB3; PSMD8; PSMC4
R-HSA-176814 Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins 6.42 2.98e-14 3.10e-13 24/69 PSMB2; PSMA5; PSMD4; RPS27A; MAD2L1; CCNB1; PSMB8; PSMB9; PSMB1; PSMA2; PSMC2; PSMB7; PSMD13; PSMA1; UBC; PSME1; PSME2; PSMA3; PSMA4; PSMB6; UBB; PSMB3; PSMD8; PSMC4
R-HSA-174178 APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 6.34 5.02e-13 4.00e-12 22/64 PSMB2; PSMA5; PSMD4; RPS27A; PSMB8; PSMB9; PSMB1; PSMA2; PSMC2; PSMB7; PSMD13; PSMA1; UBC; PSME1; PSME2; PSMA3; PSMA4; PSMB6; UBB; PSMB3; PSMD8; PSMC4
R-HSA-4086400 PCP/CE pathway 6.34 5.02e-13 4.00e-12 22/64 PSMB2; PSMA5; PSMD4; RPS27A; PSMB8; PSMB9; PSMB1; PSMA2; PSMC2; PSMB7; PSMD13; PSMA1; UBC; PSME1; PSME2; PSMA3; PSMA4; PSMB6; UBB; PSMB3; PSMD8; PSMC4
R-HSA-422475 Axon guidance 6.32 0.00e+00 0.00e+00 88/257 PSMB2; CAP1; RPS8; MAGOH; PSMA5; PSMD4; RPS27; RPS27A; RPL31; ACTR3; RPL37A; RPL32; RPL29; RPL34; RPS3A; RPL37; RPS23; RPS14; PSMB8; PSMB9; RPS18; HSP90AB1; RPS12; PSMB1; ACTB; PSMA2; PSMC2; RPS4X; RPL10; RPS20; RPL30; RPL8; RPS6; PSMB7; RPL35; RPL12; TUBB4B; PSMD13; RPLP2; RPL27A; PSMA1; RPS13; CFL1; RPS3; HSPA8; TUBA1B; TUBA1A; RPL41; MYL6; ARPC3; RPLP0; UBC; RPL21; PSME1; PSME2; RPS29; PSMA3; HSP90AA1; RPLP1; PSMA4; RPS17; RPS2; RPL13; PSMB6; RPL26; UBB; RPL23A; PSMB3; RPL19; RPL27; RPL38; EIF4A3; ACTG1; MYL12A; MYL12B; RPS21; RPS15; RPL36; RPS28; RPL18A; PSMD8; RPS16; PSMC4; RPS19; RPL18; RPL13A; RPL28; RPL3
R-HSA-69202 Cyclin E associated events during G1/S transition 6.24 2.12e-13 1.85e-12 23/68 PSMB2; PSMA5; PSMD4; RPS27A; SKP1; PSMB8; PSMB9; PSMB1; PSMA2; PSMC2; PSMB7; PSMD13; PSMA1; UBC; PSME1; PSME2; PSMA3; PSMA4; PSMB6; UBB; PSMB3; PSMD8; PSMC4
R-HSA-5668541 TNFR2 non-canonical NF-kB pathway 6.24 2.12e-13 1.85e-12 23/68 PSMB2; PSMA5; PSMD4; RPS27A; SKP1; PSMB8; PSMB9; PSMB1; PSMA2; PSMC2; PSMB7; PSMD13; PSMA1; UBC; PSME1; PSME2; PSMA3; PSMA4; PSMB6; UBB; PSMB3; PSMD8; PSMC4
R-HSA-5687128 MAPK6/MAPK4 signaling 6.24 2.12e-13 1.85e-12 23/68 PSMB2; PSMA5; PSMD4; RPS27A; PSMB8; PSMB9; PSMB1; SEPT7; PSMA2; PSMC2; PSMB7; PSMD13; PSMA1; UBC; PSME1; PSME2; PSMA3; PSMA4; PSMB6; UBB; PSMB3; PSMD8; PSMC4
R-HSA-8878166 Transcriptional regulation by RUNX2 6.24 6.22e-14 5.92e-13 24/71 PSMB2; PSMA5; PSMD4; RPS27A; CCNB1; SKP1; PSMB8; PSMB9; PSMB1; PSMA2; PSMC2; PSMB7; PSMD13; PSMA1; UBC; PSME1; PSME2; PSMA3; PSMA4; PSMB6; UBB; PSMB3; PSMD8; PSMC4
R-HSA-1168372 Downstream signaling events of B Cell Receptor (BCR) 6.23 1.82e-14 2.12e-13 25/74 PSMB2; PSMA5; PSMD4; CALM2; RPS27A; SKP1; PSMB8; PSMB9; PSMB1; PSMA2; PPIA; PSMC2; PSMB7; PSMD13; PSMA1; UBC; PSME1; PSME2; PSMA3; PSMA4; PSMB6; UBB; PSMB3; PSMD8; PSMC4
R-HSA-69656 Cyclin A:Cdk2-associated events at S phase entry 6.15 3.04e-13 2.61e-12 23/69 PSMB2; PSMA5; PSMD4; RPS27A; SKP1; PSMB8; PSMB9; PSMB1; PSMA2; PSMC2; PSMB7; PSMD13; PSMA1; UBC; PSME1; PSME2; PSMA3; PSMA4; PSMB6; UBB; PSMB3; PSMD8; PSMC4
R-HSA-8876384 Listeria monocytogenes entry into host cells 6.15 2.94e-03 1.32e-02 4/12 RPS27A; CTNNB1; UBC; UBB
R-HSA-5627117 RHO GTPases Activate ROCKs 6.15 2.94e-03 1.32e-02 4/12 CFL1; MYL6; MYL12A; MYL12B
R-HSA-175474 Assembly Of The HIV Virion 6.15 2.94e-03 1.32e-02 4/12 RPS27A; PPIA; UBC; UBB
R-HSA-5358351 Signaling by Hedgehog 6.15 7.55e-15 9.69e-14 26/78 PSMB2; PSMA5; PSMD4; RPS27A; SKP1; PSMB8; PSMB9; PSMB1; PSMA2; PSMC2; PSMB7; TUBB4B; PSMD13; PSMA1; TUBA1B; TUBA1A; UBC; PSME1; PSME2; PSMA3; PSMA4; PSMB6; UBB; PSMB3; PSMD8; PSMC4
R-HSA-174143 APC/C-mediated degradation of cell cycle proteins 6.15 2.60e-14 2.81e-13 25/75 PSMB2; PSMA5; PSMD4; RPS27A; MAD2L1; CCNB1; SKP1; PSMB8; PSMB9; PSMB1; PSMA2; PSMC2; PSMB7; PSMD13; PSMA1; UBC; PSME1; PSME2; PSMA3; PSMA4; PSMB6; UBB; PSMB3; PSMD8; PSMC4
R-HSA-453276 Regulation of mitotic cell cycle 6.15 2.60e-14 2.81e-13 25/75 PSMB2; PSMA5; PSMD4; RPS27A; MAD2L1; CCNB1; SKP1; PSMB8; PSMB9; PSMB1; PSMA2; PSMC2; PSMB7; PSMD13; PSMA1; UBC; PSME1; PSME2; PSMA3; PSMA4; PSMB6; UBB; PSMB3; PSMD8; PSMC4
R-HSA-445355 Smooth Muscle Contraction 6.15 2.53e-04 1.29e-03 6/18 CALM2; ANXA6; ANXA1; MYL6; MYL12A; MYL12B
R-HSA-71291 Metabolism of amino acids and derivatives 6.09 0.00e+00 0.00e+00 70/212 SRM; PSMB2; RPS8; PSMA5; PSMD4; RPS27; RPS27A; RPL31; RPL37A; RPL32; RPL29; RPL34; RPS3A; RPL37; RPS23; RPS14; PSMB8; PSMB9; RPS18; RPS12; PSMB1; PSMA2; PSMC2; RPS4X; RPL10; RPS20; RPL30; RPL8; RPS6; PSMB7; RPL35; RPL12; PSMD13; RPLP2; RPL27A; PSMA1; RPS13; RPS3; RPL41; RPLP0; RPL21; PSME1; PSME2; RPS29; PSMA3; RPLP1; PSMA4; RPS17; RPS2; RPL13; PSMB6; RPL26; RPL23A; PSMB3; RPL19; RPL27; RPL38; RPS21; RPS15; RPL36; RPS28; RPL18A; PSMD8; RPS16; PSMC4; RPS19; RPL18; RPL13A; RPL28; RPL3
R-HSA-202424 Downstream TCR signaling 6.07 1.08e-14 1.31e-13 26/79 PSMB2; PSMA5; PSMD4; RPS27A; SKP1; HLA-DRA; HLA-DRB1; PSMB8; PSMB9; PSMB1; PSMA2; PSMC2; PSMB7; PSMD13; PSMA1; CD3D; UBC; PSME1; PSME2; PSMA3; PSMA4; PSMB6; UBB; PSMB3; PSMD8; PSMC4
R-HSA-9020702 Interleukin-1 signaling 6.06 4.31e-13 3.57e-12 23/70 PSMB2; PSMA5; PSMD4; RPS27A; SKP1; PSMB8; PSMB9; PSMB1; PSMA2; PSMC2; PSMB7; PSMD13; PSMA1; UBC; PSME1; PSME2; PSMA3; PSMA4; PSMB6; UBB; PSMB3; PSMD8; PSMC4
R-HSA-6791226 Major pathway of rRNA processing in the nucleolus and cytosol 5.84 0.00e+00 0.00e+00 50/158 RPS8; RPS27; RPS27A; RPL31; RPL37A; RPL32; RPL29; RPL34; RPS3A; RPL37; RPS23; RPS14; RPS18; RPS12; RPS4X; RPL10; RPS20; RPL30; RPL8; RPS6; RPL35; RPL12; RPLP2; RPL27A; RPS13; RPS3; RPL41; RPLP0; RPL21; RPS29; RPLP1; RPS17; RPS2; RPL13; RPL26; RPL23A; RPL19; RPL27; RPL38; RPS21; RPS15; RPL36; RPS28; RPL18A; RPS16; RPS19; RPL18; RPL13A; RPL28; RPL3
R-HSA-983170 Antigen Presentation: Folding, assembly and peptide loading of class I MHC 5.83 3.53e-04 1.74e-03 6/19 HLA-A; HLA-C; HLA-B; HSPA5; PDIA3; B2M
R-HSA-6814122 Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding 5.83 3.53e-04 1.74e-03 6/19 CCT3; CCT4; CCT7; CCT5; CCT2; CCT8
R-HSA-69002 DNA Replication Pre-Initiation 5.81 1.19e-12 9.21e-12 23/73 PSMB2; PSMA5; PSMD4; RPS27A; PSMB8; PSMB9; PSMB1; PSMA2; MCM7; PSMC2; PSMB7; PSMD13; PSMA1; UBC; PSME1; PSME2; PSMA3; PSMA4; PSMB6; UBB; PSMB3; PSMD8; PSMC4
R-HSA-5689603 UCH proteinases 5.81 1.19e-12 9.21e-12 23/73 PSMB2; PSMA5; PSMD4; RPS27A; PSMB8; PSMB9; PSMB1; ACTB; PSMA2; PSMC2; PSMB7; PSMD13; PSMA1; UBC; PSME1; PSME2; PSMA3; PSMA4; PSMB6; UBB; PSMB3; PSMD8; PSMC4
R-HSA-69052 Switching of origins to a post-replicative state 5.75 4.83e-13 3.92e-12 24/77 PSMB2; PSMA5; PSMD4; RPS27A; SKP1; PSMB8; PSMB9; PSMB1; PSMA2; MCM7; PSMC2; PSMB7; PSMD13; PSMA1; UBC; PSME1; PSME2; PSMA3; PSMA4; PSMB6; UBB; PSMB3; PSMD8; PSMC4
R-HSA-5607764 CLEC7A (Dectin-1) signaling 5.68 6.65e-13 5.26e-12 24/78 PSMB2; PSMA5; PSMD4; CALM2; RPS27A; SKP1; PSMB8; PSMB9; PSMB1; PSMA2; PSMC2; PSMB7; PSMD13; PSMA1; UBC; PSME1; PSME2; PSMA3; PSMA4; PSMB6; UBB; PSMB3; PSMD8; PSMC4
R-HSA-1236382 Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants 5.68 4.07e-03 1.76e-02 4/13 RPS27A; UBC; HSP90AA1; UBB
R-HSA-1643713 Signaling by EGFR in Cancer 5.68 4.07e-03 1.76e-02 4/13 RPS27A; UBC; HSP90AA1; UBB
R-HSA-5637815 Signaling by Ligand-Responsive EGFR Variants in Cancer 5.68 4.07e-03 1.76e-02 4/13 RPS27A; UBC; HSP90AA1; UBB
R-HSA-5684264 MAP3K8 (TPL2)-dependent MAPK1/3 activation 5.68 4.07e-03 1.76e-02 4/13 RPS27A; SKP1; UBC; UBB
R-HSA-8868773 rRNA processing in the nucleus and cytosol 5.49 0.00e+00 0.00e+00 50/168 RPS8; RPS27; RPS27A; RPL31; RPL37A; RPL32; RPL29; RPL34; RPS3A; RPL37; RPS23; RPS14; RPS18; RPS12; RPS4X; RPL10; RPS20; RPL30; RPL8; RPS6; RPL35; RPL12; RPLP2; RPL27A; RPS13; RPS3; RPL41; RPLP0; RPL21; RPS29; RPLP1; RPS17; RPS2; RPL13; RPL26; RPL23A; RPL19; RPL27; RPL38; RPS21; RPS15; RPL36; RPS28; RPL18A; RPS16; RPS19; RPL18; RPL13A; RPL28; RPL3
R-HSA-450531 Regulation of mRNA stability by proteins that bind AU-rich elements 5.47 1.68e-12 1.26e-11 24/81 PSMB2; PSMA5; PSMD4; RPS27A; PSMB8; PSMB9; PSMB1; PSMA2; PSMC2; PSMB7; SET; PSMD13; PSMA1; HSPA8; UBC; PSME1; PSME2; PSMA3; PSMA4; PSMB6; UBB; PSMB3; PSMD8; PSMC4
R-HSA-163210 Formation of ATP by chemiosmotic coupling 5.43 1.61e-03 7.61e-03 5/17 ATP5F1; ATP5G3; ATP5C1; ATP5B; ATP5A1
R-HSA-8950505 Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation 5.36 2.41e-05 1.27e-04 9/31 HSPA9; HNRNPA2B1; PPIA; TALDO1; CFL1; HNRNPF; GSTO1; RPLP0; PSME2
R-HSA-72312 rRNA processing 5.27 0.00e+00 0.00e+00 50/175 RPS8; RPS27; RPS27A; RPL31; RPL37A; RPL32; RPL29; RPL34; RPS3A; RPL37; RPS23; RPS14; RPS18; RPS12; RPS4X; RPL10; RPS20; RPL30; RPL8; RPS6; RPL35; RPL12; RPLP2; RPL27A; RPS13; RPS3; RPL41; RPLP0; RPL21; RPS29; RPLP1; RPS17; RPS2; RPL13; RPL26; RPL23A; RPL19; RPL27; RPL38; RPS21; RPS15; RPL36; RPS28; RPL18A; RPS16; RPS19; RPL18; RPL13A; RPL28; RPL3
R-HSA-8863795 Downregulation of ERBB2 signaling 5.27 5.46e-03 2.32e-02 4/14 RPS27A; UBC; HSP90AA1; UBB
R-HSA-446652 Interleukin-1 family signaling 5.24 1.36e-11 9.69e-11 23/81 PSMB2; PSMA5; PSMD4; RPS27A; SKP1; PSMB8; PSMB9; PSMB1; PSMA2; PSMC2; PSMB7; PSMD13; PSMA1; UBC; PSME1; PSME2; PSMA3; PSMA4; PSMB6; UBB; PSMB3; PSMD8; PSMC4
R-HSA-3858494 Beta-catenin independent WNT signaling 5.09 9.37e-12 6.75e-11 24/87 PSMB2; PSMA5; PSMD4; CALM2; RPS27A; CTNNB1; PSMB8; PSMB9; PSMB1; PSMA2; PSMC2; PSMB7; PSMD13; PSMA1; UBC; PSME1; PSME2; PSMA3; PSMA4; PSMB6; UBB; PSMB3; PSMD8; PSMC4
R-HSA-5663205 Infectious disease 5.06 0.00e+00 0.00e+00 84/306 PSMB2; RPS8; PSMA5; PSMD4; RPS27; CALM2; RPS27A; RPL31; XRCC5; RPL37A; RPL32; CTNNB1; RPL29; RPL34; RPS3A; RPL37; RPS23; SKP1; RPS14; NPM1; PSMB8; PSMB9; RPS18; HSP90AB1; RPS12; PSMB1; PSMA2; PPIA; PSMC2; RPS4X; SLC25A5; RPL10; RPS20; RPL30; RPL8; RPS6; PSMB7; RPL35; RPL12; PSMD13; RPLP2; RPL27A; PSMA1; RPS13; POLR2G; RPS3; RPL41; RPLP0; UBC; RAN; RPL21; PSME1; PSME2; RPS29; PSMA3; HSP90AA1; B2M; RPLP1; PSMA4; RPS17; RPS2; RPL13; PSMB6; RPL26; UBB; RPL23A; PSMB3; RPL19; RPL27; RPL38; RPS21; RPS15; RPL36; RPS28; RPL18A; PSMD8; RPS16; PSMC4; RPS19; RPL18; RPL13A; RPL28; RPL3; XRCC6
R-HSA-202403 TCR signaling 5.05 1.45e-12 1.11e-11 26/95 PSMB2; PSMA5; PSMD4; RPS27A; SKP1; HLA-DRA; HLA-DRB1; PSMB8; PSMB9; PSMB1; PSMA2; PSMC2; PSMB7; PSMD13; PSMA1; CD3D; UBC; PSME1; PSME2; PSMA3; PSMA4; PSMB6; UBB; PSMB3; PSMD8; PSMC4
R-HSA-983705 Signaling by the B Cell Receptor (BCR) 5.01 4.83e-12 3.57e-11 25/92 PSMB2; PSMA5; PSMD4; CALM2; RPS27A; SKP1; PSMB8; PSMB9; PSMB1; PSMA2; PPIA; PSMC2; PSMB7; PSMD13; PSMA1; UBC; PSME1; PSME2; PSMA3; PSMA4; PSMB6; UBB; PSMB3; PSMD8; PSMC4
R-HSA-5627123 RHO GTPases activate PAKs 4.92 7.13e-03 2.97e-02 4/15 CALM2; MYL6; MYL12A; MYL12B
R-HSA-2173795 Downregulation of SMAD2/3:SMAD4 transcriptional activity 4.92 7.13e-03 2.97e-02 4/15 HDAC1; RPS27A; UBC; UBB
R-HSA-8982491 Glycogen metabolism 4.92 7.13e-03 2.97e-02 4/15 CALM2; RPS27A; UBC; UBB
R-HSA-69206 G1/S Transition 4.84 1.62e-12 1.23e-11 27/103 HDAC1; PSMB2; PSMA5; PSMD4; RPS27A; CCNB1; SKP1; PSMB8; PSMB9; PSMB1; PSMA2; MCM7; PSMC2; PSMB7; PSMD13; PSMA1; UBC; PSME1; PSME2; PSMA3; PSMA4; PSMB6; UBB; PSMB3; PCNA; PSMD8; PSMC4
R-HSA-5621481 C-type lectin receptors (CLRs) 4.81 3.48e-11 2.43e-10 24/92 PSMB2; PSMA5; PSMD4; CALM2; RPS27A; SKP1; PSMB8; PSMB9; PSMB1; PSMA2; PSMC2; PSMB7; PSMD13; PSMA1; UBC; PSME1; PSME2; PSMA3; PSMA4; PSMB6; UBB; PSMB3; PSMD8; PSMC4
R-HSA-373755 Semaphorin interactions 4.81 1.09e-03 5.27e-03 6/23 HSP90AB1; CFL1; MYL6; HSP90AA1; MYL12A; MYL12B
R-HSA-390471 Association of TriC/CCT with target proteins during biosynthesis 4.81 1.09e-03 5.27e-03 6/23 CCT3; CCT4; CCT7; CCT5; CCT2; CCT8
R-HSA-1266738 Developmental Biology 4.79 0.00e+00 0.00e+00 92/354 PSMB2; CAP1; RPS8; MAGOH; PSMA5; PSMD4; RPS27; RPS27A; RPL31; ACTR3; RPL37A; RPL32; CTNNB1; RPL29; RPL34; RPS3A; RPL37; RPS23; RPS14; HIST1H4C; PSMB8; PSMB9; RPS18; HSP90AB1; RPS12; PSMB1; ACTB; PSMA2; PSMC2; RPS4X; RPL10; RPS20; RPL30; RPL8; RPS6; PSMB7; RPL35; RPL12; TUBB4B; PSMD13; RPLP2; RPL27A; PSMA1; RPS13; POLR2G; CFL1; RPS3; HSPA8; TUBA1B; TUBA1A; RPL41; MYL6; ARPC3; RPLP0; UBC; RPL21; PSME1; PSME2; RPS29; PSMA3; HSP90AA1; RPLP1; PSMA4; RPS17; RPS2; RPL13; PSMB6; RPL26; UBB; RPL23A; SUZ12; PSMB3; RPL19; RPL27; RPL38; EIF4A3; ACTG1; MYL12A; MYL12B; RPS21; RPS15; RPL36; RPS28; RPL18A; PSMD8; RPS16; PSMC4; RPS19; RPL18; RPL13A; RPL28; RPL3
R-HSA-69239 Synthesis of DNA 4.75 1.75e-11 1.24e-10 25/97 PSMB2; PSMA5; PSMD4; RPS27A; SKP1; PSMB8; PSMB9; PSMB1; PSMA2; MCM7; PSMC2; PSMB7; PSMD13; PSMA1; UBC; PSME1; PSME2; PSMA3; PSMA4; PSMB6; UBB; PSMB3; PCNA; PSMD8; PSMC4
R-HSA-9020591 Interleukin-12 signaling 4.74 6.97e-05 3.61e-04 9/35 HSPA9; HNRNPA2B1; PPIA; TALDO1; CFL1; HNRNPF; GSTO1; RPLP0; PSME2
R-HSA-162909 Host Interactions of HIV factors 4.70 1.33e-12 1.03e-11 28/110 PSMB2; PSMA5; PSMD4; RPS27A; SKP1; NPM1; PSMB8; PSMB9; PSMB1; PSMA2; PPIA; PSMC2; SLC25A5; PSMB7; PSMD13; PSMA1; UBC; RAN; PSME1; PSME2; PSMA3; B2M; PSMA4; PSMB6; UBB; PSMB3; PSMD8; PSMC4
R-HSA-201681 TCF dependent signaling in response to WNT 4.61 3.64e-11 2.52e-10 25/100 HDAC1; PSMB2; PSMA5; PSMD4; RPS27A; CTNNB1; HIST1H4C; PSMB8; PSMB9; PSMB1; PSMA2; PSMC2; PSMB7; PSMD13; PSMA1; UBC; PSME1; PSME2; PSMA3; PSMA4; PSMB6; UBB; PSMB3; PSMD8; PSMC4
R-HSA-3928662 EPHB-mediated forward signaling 4.61 3.54e-03 1.58e-02 5/20 ACTR3; ACTB; CFL1; ARPC3; ACTG1
R-HSA-2672351 Stimuli-sensing channels 4.61 9.11e-03 3.67e-02 4/16 CALM2; RPS27A; UBC; UBB
R-HSA-110312 Translesion synthesis by REV1 4.61 9.11e-03 3.67e-02 4/16 RPS27A; UBC; UBB; PCNA
R-HSA-5656121 Translesion synthesis by POLI 4.61 9.11e-03 3.67e-02 4/16 RPS27A; UBC; UBB; PCNA
R-HSA-2454202 Fc epsilon receptor (FCERI) signaling 4.52 1.48e-10 9.80e-10 24/98 PSMB2; PSMA5; PSMD4; CALM2; RPS27A; SKP1; PSMB8; PSMB9; PSMB1; PSMA2; PSMC2; PSMB7; PSMD13; PSMA1; UBC; PSME1; PSME2; PSMA3; PSMA4; PSMB6; UBB; PSMB3; PSMD8; PSMC4
R-HSA-69306 DNA Replication 4.48 7.33e-11 5.00e-10 25/103 PSMB2; PSMA5; PSMD4; RPS27A; SKP1; PSMB8; PSMB9; PSMB1; PSMA2; MCM7; PSMC2; PSMB7; PSMD13; PSMA1; UBC; PSME1; PSME2; PSMA3; PSMA4; PSMB6; UBB; PSMB3; PCNA; PSMD8; PSMC4
R-HSA-3371497 HSP90 chaperone cycle for steroid hormone receptors (SHR) 4.47 2.78e-04 1.39e-03 8/33 CAPZB; HSP90AB1; DNAJA1; TUBB4B; HSPA8; TUBA1B; TUBA1A; HSP90AA1
R-HSA-6807070 PTEN Regulation 4.43 2.34e-10 1.54e-09 24/100 HDAC1; PSMB2; PSMA5; PSMD4; RPS27A; PSMB8; PSMB9; PSMB1; PSMA2; PSMC2; PSMB7; PSMD13; PSMA1; UBC; PSME1; PSME2; PSMA3; PSMA4; PSMB6; UBB; SUZ12; PSMB3; PSMD8; PSMC4
R-HSA-977225 Amyloid fiber formation 4.43 1.75e-03 8.21e-03 6/25 RPS27A; HIST1H4C; UBC; ITM2B; B2M; UBB
R-HSA-453279 Mitotic G1-G1/S phases 4.37 2.20e-11 1.55e-10 27/114 HDAC1; PSMB2; PSMA5; PSMD4; RPS27A; CCNB1; SKP1; PSMB8; PSMB9; PSMB1; PSMA2; MCM7; PSMC2; PSMB7; PSMD13; PSMA1; UBC; PSME1; PSME2; PSMA3; PSMA4; PSMB6; UBB; PSMB3; PCNA; PSMD8; PSMC4
R-HSA-5655862 Translesion synthesis by POLK 4.34 1.14e-02 4.48e-02 4/17 RPS27A; UBC; UBB; PCNA
R-HSA-5673001 RAF/MAP kinase cascade 4.32 7.02e-11 4.82e-10 26/111 PSMB2; PSMA5; PSMD4; CALM2; RPS27A; PSMB8; PSMB9; PSMB1; ACTB; PSMA2; PSMC2; IL2RG; PSMB7; PSMD13; PSMA1; UBC; PSME1; PSME2; PSMA3; PSMA4; PSMB6; UBB; PSMB3; ACTG1; PSMD8; PSMC4
R-HSA-157118 Signaling by NOTCH 4.28 8.71e-11 5.89e-10 26/112 HDAC1; PSMB2; YBX1; PSMA5; PSMD4; RPS27A; SKP1; HIST1H4C; PSMB8; PSMB9; PSMB1; PSMA2; PSMC2; PSMB7; PSMD13; PSMA1; UBC; PSME1; PSME2; PSMA3; PSMA4; PSMB6; UBB; PSMB3; PSMD8; PSMC4
R-HSA-8949613 Cristae formation 4.26 2.18e-03 1.00e-02 6/26 ATP5F1; ATP5G3; HSPA9; ATP5C1; ATP5B; ATP5A1
R-HSA-69481 G2/M Checkpoints 4.24 1.08e-10 7.24e-10 26/113 PSMB2; PSMA5; PSMD4; RPS27A; CCNB1; HIST1H4C; PSMB8; PSMB9; PSMB1; PSMA2; MCM7; PSMC2; PSMB7; PSMD13; PSMA1; UBC; PSME1; PSME2; PSMA3; CCNB2; PSMA4; PSMB6; UBB; PSMB3; PSMD8; PSMC4
R-HSA-5684996 MAPK1/MAPK3 signaling 4.21 1.33e-10 8.88e-10 26/114 PSMB2; PSMA5; PSMD4; CALM2; RPS27A; PSMB8; PSMB9; PSMB1; ACTB; PSMA2; PSMC2; IL2RG; PSMB7; PSMD13; PSMA1; UBC; PSME1; PSME2; PSMA3; PSMA4; PSMB6; UBB; PSMB3; ACTG1; PSMD8; PSMC4
R-HSA-5620920 Cargo trafficking to the periciliary membrane 4.19 5.50e-03 2.32e-02 5/22 CCT3; CCT4; CCT5; CCT2; CCT8
R-HSA-3769402 Deactivation of the beta-catenin transactivating complex 4.19 5.50e-03 2.32e-02 5/22 HDAC1; RPS27A; CTNNB1; UBC; UBB
R-HSA-6803529 FGFR2 alternative splicing 4.19 5.50e-03 2.32e-02 5/22 HNRNPH1; POLR2G; HNRNPF; HNRNPA1; HNRNPM
R-HSA-447115 Interleukin-12 family signaling 4.15 2.13e-04 1.09e-03 9/40 HSPA9; HNRNPA2B1; PPIA; TALDO1; CFL1; HNRNPF; GSTO1; RPLP0; PSME2
R-HSA-69275 G2/M Transition 4.06 5.14e-12 3.76e-11 31/141 PSMB2; PSMA5; PSMD4; RPS27A; CCNB1; SKP1; TUBB; PSMB8; PSMB9; HSP90AB1; PSMB1; PSMA2; PSMC2; PSMB7; TUBB4B; PSMD13; PSMA1; TUBA1B; TUBA1A; UBC; PSME1; PSME2; PSMA3; HSP90AA1; CCNB2; PSMA4; PSMB6; UBB; PSMB3; PSMD8; PSMC4
R-HSA-390466 Chaperonin-mediated protein folding 4.01 1.29e-04 6.62e-04 10/46 CCT3; CCT4; CCT7; CCT5; ACTB; TUBB4B; TUBA1B; TUBA1A; CCT2; CCT8
R-HSA-453274 Mitotic G2-G2/M phases 4.00 7.64e-12 5.55e-11 31/143 PSMB2; PSMA5; PSMD4; RPS27A; CCNB1; SKP1; TUBB; PSMB8; PSMB9; HSP90AB1; PSMB1; PSMA2; PSMC2; PSMB7; TUBB4B; PSMD13; PSMA1; TUBA1B; TUBA1A; UBC; PSME1; PSME2; PSMA3; HSP90AA1; CCNB2; PSMA4; PSMB6; UBB; PSMB3; PSMD8; PSMC4
R-HSA-2682334 EPH-Ephrin signaling 3.88 7.76e-04 3.78e-03 8/38 ACTR3; ACTB; CFL1; MYL6; ARPC3; ACTG1; MYL12A; MYL12B
R-HSA-2122947 NOTCH1 Intracellular Domain Regulates Transcription 3.84 8.13e-03 3.33e-02 5/24 HDAC1; RPS27A; SKP1; UBC; UBB
R-HSA-72766 Translation 3.83 0.00e+00 0.00e+00 55/265 EIF3I; RPS8; RPS27; RPS27A; RPL31; RPL37A; RPL32; RPL29; SPCS1; RPL34; RPS3A; RPL37; RPS23; RPS14; RPS18; RPS12; RPS4X; RPL10; RPS20; RPL30; MRPL13; RPL8; RPS6; RPL35; RPL12; RPLP2; RPL27A; RPS13; SPCS2; RPS3; RPL41; RPLP0; RPL21; RPS29; RPLP1; RPS17; RPS2; RPL13; RPL26; RPL23A; RPL19; RPL27; RPL38; RPN2; RPS21; RPS15; RPL36; RPS28; RPL18A; RPS16; RPS19; RPL18; RPL13A; RPL28; RPL3
R-HSA-8878171 Transcriptional regulation by RUNX1 3.81 2.89e-09 1.83e-08 25/121 HDAC1; PSMB2; PSMA5; PSMD4; RPS27A; HIST1H4C; PSMB8; PSMB9; PSMB1; PSMA2; PSMC2; PSMB7; PSMD13; PSMA1; UBC; PSME1; PSME2; PSMA3; PSMA4; PSMB6; UBB; PSMB3; PSMD8; PSMC4; PRMT1
R-HSA-109581 Apoptosis 3.72 1.02e-08 6.26e-08 24/119 PSMB2; PSMA5; PSMD4; RPS27A; CTNNB1; HIST1H1B; PSMB8; PSMB9; PSMB1; PSMA2; PSMC2; PSMB7; PSMD13; PSMA1; UBC; PSME1; PSME2; PSMA3; PSMA4; PSMB6; UBB; PSMB3; PSMD8; PSMC4
R-HSA-5357801 Programmed Cell Death 3.69 1.22e-08 7.41e-08 24/120 PSMB2; PSMA5; PSMD4; RPS27A; CTNNB1; HIST1H1B; PSMB8; PSMB9; PSMB1; PSMA2; PSMC2; PSMB7; PSMD13; PSMA1; UBC; PSME1; PSME2; PSMA3; PSMA4; PSMB6; UBB; PSMB3; PSMD8; PSMC4
R-HSA-5654738 Signaling by FGFR2 3.69 1.11e-03 5.32e-03 8/40 RPS27A; HNRNPH1; POLR2G; HNRNPF; HNRNPA1; UBC; UBB; HNRNPM
R-HSA-437239 Recycling pathway of L1 3.69 9.72e-03 3.90e-02 5/25 ACTB; TUBB4B; TUBA1B; TUBA1A; ACTG1
R-HSA-5683057 MAPK family signaling cascades 3.69 1.36e-09 8.82e-09 27/135 PSMB2; PSMA5; PSMD4; CALM2; RPS27A; PSMB8; PSMB9; PSMB1; ACTB; SEPT7; PSMA2; PSMC2; IL2RG; PSMB7; PSMD13; PSMA1; UBC; PSME1; PSME2; PSMA3; PSMA4; PSMB6; UBB; PSMB3; ACTG1; PSMD8; PSMC4
R-HSA-391251 Protein folding 3.62 3.18e-04 1.58e-03 10/51 CCT3; CCT4; CCT7; CCT5; ACTB; TUBB4B; TUBA1B; TUBA1A; CCT2; CCT8
R-HSA-69242 S Phase 3.60 9.85e-09 6.06e-08 25/128 PSMB2; PSMA5; PSMD4; RPS27A; SKP1; PSMB8; PSMB9; PSMB1; PSMA2; MCM7; PSMC2; PSMB7; PSMD13; PSMA1; UBC; PSME1; PSME2; PSMA3; PSMA4; PSMB6; UBB; PSMB3; PCNA; PSMD8; PSMC4
R-HSA-190236 Signaling by FGFR 3.60 1.32e-03 6.24e-03 8/41 RPS27A; HNRNPH1; POLR2G; HNRNPF; HNRNPA1; UBC; UBB; HNRNPM
R-HSA-2644602 Signaling by NOTCH1 PEST Domain Mutants in Cancer 3.55 1.15e-02 4.48e-02 5/26 HDAC1; RPS27A; SKP1; UBC; UBB
R-HSA-2644603 Signaling by NOTCH1 in Cancer 3.55 1.15e-02 4.48e-02 5/26 HDAC1; RPS27A; SKP1; UBC; UBB
R-HSA-2644606 Constitutive Signaling by NOTCH1 PEST Domain Mutants 3.55 1.15e-02 4.48e-02 5/26 HDAC1; RPS27A; SKP1; UBC; UBB
R-HSA-2894858 Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer 3.55 1.15e-02 4.48e-02 5/26 HDAC1; RPS27A; SKP1; UBC; UBB
R-HSA-2894862 Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants 3.55 1.15e-02 4.48e-02 5/26 HDAC1; RPS27A; SKP1; UBC; UBB
R-HSA-5689880 Ub-specific processing proteases 3.53 1.21e-07 6.93e-07 22/115 PSMB2; PSMA5; PSMD4; RPS27A; PSMB8; PSMB9; PSMB1; PSMA2; PSMC2; PSMB7; PSMD13; PSMA1; UBC; PSME1; PSME2; PSMA3; PSMA4; PSMB6; UBB; PSMB3; PSMD8; PSMC4
R-HSA-2029482 Regulation of actin dynamics for phagocytic cup formation 3.49 3.17e-03 1.42e-02 7/37 ACTR3; HSP90AB1; ACTB; CFL1; ARPC3; HSP90AA1; ACTG1
R-HSA-195721 Signaling by WNT 3.44 7.16e-09 4.47e-08 27/145 HDAC1; PSMB2; PSMA5; PSMD4; CALM2; RPS27A; CTNNB1; SKP1; HIST1H4C; PSMB8; PSMB9; PSMB1; PSMA2; PSMC2; PSMB7; PSMD13; PSMA1; UBC; PSME1; PSME2; PSMA3; PSMA4; PSMB6; UBB; PSMB3; PSMD8; PSMC4
R-HSA-2467813 Separation of Sister Chromatids 3.32 1.54e-08 9.30e-08 27/150 PSMB2; PSMA5; PSMD4; RPS27; RPS27A; MAD2L1; PSMB8; PSMB9; PSMB1; PSMA2; PSMC2; PSMB7; TUBB4B; PSMD13; PSMA1; TUBA1B; TUBA1A; UBC; PSME1; PSME2; PSMA3; PSMA4; PSMB6; UBB; PSMB3; PSMD8; PSMC4
R-HSA-1257604 PIP3 activates AKT signaling 3.26 1.55e-07 8.81e-07 24/136 HDAC1; PSMB2; PSMA5; PSMD4; RPS27A; PSMB8; PSMB9; PSMB1; PSMA2; PSMC2; PSMB7; PSMD13; PSMA1; UBC; PSME1; PSME2; PSMA3; PSMA4; PSMB6; UBB; SUZ12; PSMB3; PSMD8; PSMC4
R-HSA-70171 Glycolysis 3.23 5.01e-03 2.15e-02 7/40 ENO1; PGK1; PGAM1; GAPDH; TPI1; PKM; ALDOA
R-HSA-68882 Mitotic Anaphase 3.15 4.89e-08 2.89e-07 27/158 PSMB2; PSMA5; PSMD4; RPS27; RPS27A; MAD2L1; PSMB8; PSMB9; PSMB1; PSMA2; PSMC2; PSMB7; TUBB4B; PSMD13; PSMA1; TUBA1B; TUBA1A; UBC; PSME1; PSME2; PSMA3; PSMA4; PSMB6; UBB; PSMB3; PSMD8; PSMC4
R-HSA-8951664 Neddylation 3.14 5.57e-07 3.10e-06 23/135 PSMB2; PSMA5; PSMD4; RPS27A; SKP1; PSMB8; PSMB9; PSMB1; PSMA2; PSMC2; PSMB7; PSMD13; PSMA1; UBC; PSME1; PSME2; PSMA3; PSMA4; PSMB6; UBB; PSMB3; PSMD8; PSMC4
R-HSA-2555396 Mitotic Metaphase and Anaphase 3.13 5.62e-08 3.29e-07 27/159 PSMB2; PSMA5; PSMD4; RPS27; RPS27A; MAD2L1; PSMB8; PSMB9; PSMB1; PSMA2; PSMC2; PSMB7; TUBB4B; PSMD13; PSMA1; TUBA1B; TUBA1A; UBC; PSME1; PSME2; PSMA3; PSMA4; PSMB6; UBB; PSMB3; PSMD8; PSMC4
R-HSA-9006925 Intracellular signaling by second messengers 3.10 2.33e-07 1.31e-06 25/149 HDAC1; PSMB2; PSMA5; PSMD4; CALM2; RPS27A; PSMB8; PSMB9; PSMB1; PSMA2; PSMC2; PSMB7; PSMD13; PSMA1; UBC; PSME1; PSME2; PSMA3; PSMA4; PSMB6; UBB; SUZ12; PSMB3; PSMD8; PSMC4
R-HSA-70326 Glucose metabolism 3.07 3.75e-03 1.66e-02 8/48 ENO1; MDH1; PGK1; PGAM1; GAPDH; TPI1; PKM; ALDOA
R-HSA-162906 HIV Infection 3.07 8.21e-09 5.09e-08 31/186 PSMB2; PSMA5; PSMD4; RPS27A; XRCC5; SKP1; NPM1; PSMB8; PSMB9; PSMB1; PSMA2; PPIA; PSMC2; SLC25A5; PSMB7; PSMD13; PSMA1; POLR2G; UBC; RAN; PSME1; PSME2; PSMA3; B2M; PSMA4; PSMB6; UBB; PSMB3; PSMD8; PSMC4; XRCC6
R-HSA-449147 Signaling by Interleukins 3.06 4.82e-10 3.14e-09 36/217 PSMB2; PSMA5; PSMD4; RPS27A; SKP1; HSPA9; PSMB8; PSMB9; PSMB1; HNRNPA2B1; PSMA2; PPIA; PSMC2; IL2RG; ANXA1; PSMB7; PSMD13; TALDO1; PSMA1; CFL1; HSPA8; HNRNPF; GSTO1; RPLP0; UBC; PSME1; PSME2; PSMA3; HSP90AA1; PSMA4; IL32; PSMB6; UBB; PSMB3; PSMD8; PSMC4
R-HSA-2029480 Fcgamma receptor (FCGR) dependent phagocytosis 2.94 8.57e-03 3.50e-02 7/44 ACTR3; HSP90AB1; ACTB; CFL1; ARPC3; HSP90AA1; ACTG1
R-HSA-5663202 Diseases of signal transduction 2.91 9.56e-08 5.54e-07 29/184 HDAC1; PSMB2; PSMA5; PSMD4; RPS27A; CTNNB1; SKP1; PSMB8; PSMB9; PSMB1; ACTB; PSMA2; PSMC2; PSMB7; PSMD13; PSMA1; POLR2G; UBC; PSME1; PSME2; PSMA3; HSP90AA1; PSMA4; PSMB6; UBB; PSMB3; ACTG1; PSMD8; PSMC4
R-HSA-2565942 Regulation of PLK1 Activity at G2/M Transition 2.84 2.29e-03 1.05e-02 10/65 RPS27A; CCNB1; SKP1; TUBB; TUBB4B; TUBA1A; UBC; HSP90AA1; CCNB2; UBB
R-HSA-983169 Class I MHC mediated antigen processing & presentation 2.80 7.83e-08 4.56e-07 31/204 PSMB2; PSMA5; PSMD4; RPS27A; SKP1; HLA-A; HLA-C; HLA-B; PSMB8; PSMB9; PSMB1; PSMA2; PSMC2; PSMB7; HSPA5; PSMD13; PSMA1; UBC; PSME1; PSME2; PSMA3; PDIA3; B2M; PSMA4; CYBA; PSMB6; UBB; PSMB3; PSMD8; PSMC4; UBE2S
R-HSA-2262752 Cellular responses to stress 2.77 1.78e-09 1.14e-08 39/260 CAPZB; PSMB2; PRDX1; PSMA5; PSMD4; PRDX6; RPS27A; HSPA9; HIST1H4C; HIST1H1B; PSMB8; PSMB9; HSP90AB1; PSMB1; PSMA2; PSMC2; DNAJA1; PSMB7; HSPA5; TUBB4B; PSMD13; PSMA1; HSPA8; TUBA1B; TUBA1A; UBC; PSME1; PSME2; PSMA3; HSP90AA1; PSMA4; CYBA; PSMB6; UBB; SUZ12; PSMB3; PRDX2; PSMD8; PSMC4
R-HSA-1592230 Mitochondrial biogenesis 2.73 7.83e-03 3.23e-02 8/54 ATP5F1; CALM2; ATP5G3; HSPA9; SSBP1; ATP5C1; ATP5B; ATP5A1
R-HSA-5688426 Deubiquitination 2.60 1.57e-05 8.37e-05 23/163 PSMB2; PSMA5; PSMD4; RPS27A; PSMB8; PSMB9; PSMB1; ACTB; PSMA2; PSMC2; PSMB7; PSMD13; PSMA1; UBC; PSME1; PSME2; PSMA3; PSMA4; PSMB6; UBB; PSMB3; PSMD8; PSMC4
R-HSA-983168 Antigen processing: Ubiquitination & Proteasome degradation 2.59 1.11e-05 6.00e-05 24/171 PSMB2; PSMA5; PSMD4; RPS27A; SKP1; PSMB8; PSMB9; PSMB1; PSMA2; PSMC2; PSMB7; PSMD13; PSMA1; UBC; PSME1; PSME2; PSMA3; PSMA4; PSMB6; UBB; PSMB3; PSMD8; PSMC4; UBE2S
R-HSA-1280215 Cytokine Signaling in Immune system 2.49 4.22e-09 2.65e-08 44/326 PSMB2; PSMA5; PSMD4; RPS27A; SKP1; HSPA9; HLA-A; HLA-C; HLA-B; HLA-DRA; HLA-DRB1; PSMB8; PSMB9; PSMB1; HNRNPA2B1; PSMA2; PPIA; PSMC2; IL2RG; ANXA1; PSMB7; PSMD13; TALDO1; PSMA1; CFL1; HSPA8; HNRNPF; GSTO1; RPLP0; UBC; PSME1; PSME2; PSMA3; HSP90AA1; B2M; PSMA4; IL32; PSMB6; UBB; PSMB3; EIF4A3; BST2; PSMD8; PSMC4
R-HSA-69620 Cell Cycle Checkpoints 2.47 4.88e-06 2.67e-05 28/209 PSMB2; PSMA5; PSMD4; RPS27; RPS27A; MAD2L1; CCNB1; HIST1H4C; PSMB8; PSMB9; PSMB1; PSMA2; MCM7; PSMC2; PSMB7; PSMD13; PSMA1; UBC; PSME1; PSME2; PSMA3; CCNB2; PSMA4; PSMB6; UBB; PSMB3; PSMD8; PSMC4
R-HSA-71387 Metabolism of carbohydrates 2.40 2.56e-03 1.17e-02 13/100 ENO1; CALM2; RPS27A; MDH1; PGK1; TALDO1; PGAM1; GAPDH; TPI1; UBC; PKM; ALDOA; UBB
R-HSA-8953897 Cellular responses to external stimuli 2.38 1.33e-07 7.62e-07 39/302 CAPZB; PSMB2; PRDX1; PSMA5; PSMD4; PRDX6; RPS27A; HSPA9; HIST1H4C; HIST1H1B; PSMB8; PSMB9; HSP90AB1; PSMB1; PSMA2; PSMC2; DNAJA1; PSMB7; HSPA5; TUBB4B; PSMD13; PSMA1; HSPA8; TUBA1B; TUBA1A; UBC; PSME1; PSME2; PSMA3; HSP90AA1; PSMA4; CYBA; PSMB6; UBB; SUZ12; PSMB3; PRDX2; PSMD8; PSMC4
R-HSA-68886 M Phase 2.31 2.80e-06 1.55e-05 33/263 PSMB2; PSMA5; PSMD4; RPS27; RPS27A; MAD2L1; CCNB1; HIST1H4C; TUBB; PSMB8; PSMB9; PSMB1; PSMA2; PSMC2; PSMB7; SET; TUBB4B; PSMD13; PSMA1; TUBA1B; TUBA1A; UBC; PSME1; PSME2; PSMA3; HSP90AA1; CCNB2; PSMA4; PSMB6; UBB; PSMB3; PSMD8; PSMC4
R-HSA-6798695 Neutrophil degranulation 2.30 4.80e-06 2.64e-05 32/257 CAP1; PSMA5; CD53; ILF2; SELL; PRDX6; XRCC5; TUBB; HLA-C; HLA-B; HSP90AB1; PSMB1; PSMA2; PPIA; PSMC2; ATP6AP2; PSMB7; TUBB4B; PSMD13; HSPA8; PGAM1; CCT2; HSP90AA1; B2M; PKM; ALDOA; CYBA; BST2; GMFG; FTL; XRCC6; CCT8
R-HSA-382551 Transport of small molecules 2.28 6.51e-05 3.39e-04 25/202 PSMB2; PSMA5; PSMD4; CALM2; RPS27A; SKP1; PSMB8; PSMB9; PSMB1; PSMA2; PSMC2; PSMB7; PSMD13; PSMA1; UBC; PSME1; PSME2; PSMA3; PSMA4; PSMB6; UBB; PSMB3; PSMD8; PSMC4; FTL
R-HSA-1852241 Organelle biogenesis and maintenance 2.20 1.13e-03 5.40e-03 18/151 ATP5F1; CCT3; CALM2; CCT4; ATP5G3; CCT5; HSPA9; TUBB; SSBP1; TUBB4B; ATP5C1; TUBA1B; TUBA1A; ATP5B; CCT2; HSP90AA1; ATP5A1; CCT8
R-HSA-168249 Innate Immune System 2.08 1.95e-08 1.17e-07 56/497 PSMB2; CAP1; PSMA5; CD53; PSMD4; ILF2; SELL; PRDX6; CALM2; RPS27A; ACTR3; XRCC5; CTNNB1; SKP1; TUBB; HLA-C; HLA-B; PSMB8; PSMB9; HSP90AB1; PSMB1; ACTB; PSMA2; PPIA; PSMC2; ATP6AP2; PSMB7; TUBB4B; PSMD13; PSMA1; CFL1; HSPA8; PGAM1; CCT2; ARPC3; UBC; PSME1; PSME2; PSMA3; HSP90AA1; B2M; PKM; PSMA4; ALDOA; CYBA; PSMB6; UBB; PSMB3; ACTG1; BST2; PSMD8; GMFG; PSMC4; FTL; XRCC6; CCT8
R-HSA-913531 Interferon Signaling 2.07 1.21e-02 4.68e-02 12/107 RPS27A; HLA-A; HLA-C; HLA-B; HLA-DRA; HLA-DRB1; PSMB8; UBC; B2M; UBB; EIF4A3; BST2
Factor 4 : 59 significant Reactome pathways
GeneSet description enrichRatio pValue FDR GeneRatio geneSymbols
R-HSA-6783783 Interleukin-10 signaling 6.05 2.46e-06 6.81e-05 9/15 TNFRSF1B; CXCL10; IL10RA; CCL5; CCL3; CCL4; CCL3L3; CCL4L2
R-HSA-844456 The NLRP3 inflammasome 5.04 1.54e-03 2.36e-02 5/10 TXNIP; HSP90AB1; TXN; CASP1; NFKB2
R-HSA-70221 Glycogen breakdown (glycogenolysis) 5.04 1.54e-03 2.36e-02 5/10 CALM2; GYG1; PGM2L1; CALM1
R-HSA-198933 Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell 5.04 3.31e-10 1.63e-08 19/38 SLAMF7; SELL; CD8A; HLA-F; NCR3; CD99; NPDC1; CD81; JAML; ITGB1; KLRB1; CLEC2B; KLRD1; KLRC1; ITGB7; B2M; HCST; LAIR1; ITGB2
R-HSA-445355 Smooth Muscle Contraction 5.04 1.82e-05 4.03e-04 9/18 CALM2; MYL5; ITGA1; ANXA1; CALM1; ANXA2; MYL12A; TPM4
R-HSA-216083 Integrin cell surface interactions 5.04 1.65e-04 2.99e-03 7/14 CD47; ITGA1; CD44; ITGB1; ITGB7; ITGB2; COL6A2
R-HSA-912526 Interleukin receptor SHC signaling 5.04 5.02e-04 8.24e-03 6/12 INPP5D; IL2RG; IL2RA; PTPN6; GRB2; IL2RB
R-HSA-451927 Interleukin-2 family signaling 4.58 1.77e-05 4.02e-04 10/22 STAT1; INPP5D; HAVCR2; IL2RG; IL2RA; PTPN6; IL21R; LGALS9; GRB2; IL2RB
R-HSA-2142753 Arachidonic acid metabolism 4.58 2.60e-03 3.66e-02 5/11 CYP1B1; HPGD; EPHX2; ALOX5AP; GPX4
R-HSA-373076 Class A/1 (Rhodopsin-like receptors) 4.48 3.32e-06 8.66e-05 12/27 XCL1; CXCL10; F2R; HRH2; ANXA1; LPAR6; GPR183; PTGER2; CCL5; CCR7; S1PR4; PTGIR
R-HSA-1474228 Degradation of the extracellular matrix 4.48 1.55e-04 2.87e-03 8/18 CTSS; CAPN2; CAST; CTSB; CTSD; CD44; CAPN12; COL6A2
R-HSA-156842 Eukaryotic Translation Elongation 4.41 1.11e-16 6.56e-14 38/87 RPL11; RPS8; RPL5; RPS27; RPS7; RPS27A; EEF1B2; RPL37A; RPL32; RPL15; RPL9; RPL34; RPS3A; RPS23; RPS14; RPL10A; EEF1A1; RPL10; RPS20; RPL7; RPL30; RPS6; RPL7A; RPL27A; RPS13; RPS25; RPS24; RPL6; RPL21; RPL4; RPLP1; RPS17; RPS15A; RPL13; RPL23A; RPL23; RPS15; RPS5
R-HSA-156902 Peptide chain elongation 4.39 2.22e-16 6.56e-14 37/85 RPL11; RPS8; RPL5; RPS27; RPS7; RPS27A; RPL37A; RPL32; RPL15; RPL9; RPL34; RPS3A; RPS23; RPS14; RPL10A; EEF1A1; RPL10; RPS20; RPL7; RPL30; RPS6; RPL7A; RPL27A; RPS13; RPS25; RPS24; RPL6; RPL21; RPL4; RPLP1; RPS17; RPS15A; RPL13; RPL23A; RPL23; RPS15; RPS5
R-HSA-192823 Viral mRNA Translation 4.39 2.22e-16 6.56e-14 37/85 RPL11; RPS8; RPL5; RPS27; RPS7; RPS27A; RPL37A; RPL32; RPL15; RPL9; GRSF1; RPL34; RPS3A; RPS23; RPS14; RPL10A; RPL10; RPS20; RPL7; RPL30; RPS6; RPL7A; RPL27A; RPS13; RPS25; RPS24; RPL6; RPL21; RPL4; RPLP1; RPS17; RPS15A; RPL13; RPL23A; RPL23; RPS15; RPS5
R-HSA-2408557 Selenocysteine synthesis 4.27 2.00e-15 3.54e-13 36/85 RPL11; RPS8; RPL5; RPS27; RPS7; RPS27A; RPL37A; RPL32; RPL15; RPL9; RPL34; RPS3A; RPS23; RPS14; RPL10A; RPL10; RPS20; RPL7; RPL30; RPS6; RPL7A; RPL27A; RPS13; RPS25; RPS24; RPL6; RPL21; RPL4; RPLP1; RPS17; RPS15A; RPL13; RPL23A; RPL23; RPS15; RPS5
R-HSA-975956 Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) 4.19 1.67e-15 3.54e-13 37/89 RPL11; RPS8; RPL5; RPS27; RPS7; RPS27A; RPL37A; RPL32; RPL15; RPL9; RPL34; RPS3A; RPS23; RPS14; RPL10A; RPL10; RPS20; RPL7; RPL30; PABPC1; RPS6; RPL7A; RPL27A; RPS13; RPS25; RPS24; RPL6; RPL21; RPL4; RPLP1; RPS17; RPS15A; RPL13; RPL23A; RPL23; RPS15; RPS5
R-HSA-72764 Eukaryotic Translation Termination 4.13 7.66e-15 1.13e-12 36/88 RPL11; RPS8; RPL5; RPS27; RPS7; RPS27A; RPL37A; RPL32; RPL15; RPL9; RPL34; RPS3A; RPS23; RPS14; RPL10A; RPL10; RPS20; RPL7; RPL30; RPS6; RPL7A; RPL27A; RPS13; RPS25; RPS24; RPL6; RPL21; RPL4; RPLP1; RPS17; RPS15A; RPL13; RPL23A; RPL23; RPS15; RPS5
R-HSA-375276 Peptide ligand-binding receptors 4.03 2.10e-03 3.05e-02 6/15 XCL1; CXCL10; F2R; ANXA1; CCL5; CCR7
R-HSA-8982491 Glycogen metabolism 4.03 2.10e-03 3.05e-02 6/15 CALM2; RPS27A; GYG1; PGM2L1; CALM1
R-HSA-1474244 Extracellular matrix organization 3.98 1.22e-06 3.74e-05 15/38 CTSS; CAPN2; CD47; ITGA1; CAST; CTSB; CTSD; CD44; ITGB1; ITGB7; PPIB; P4HB; CAPN12; ITGB2; COL6A2
R-HSA-72689 Formation of a pool of free 40S subunits 3.89 3.08e-14 3.89e-12 37/96 RPL11; RPS8; RPL5; RPS27; RPS7; RPS27A; RPL37A; RPL32; RPL15; RPL9; RPL34; RPS3A; RPS23; RPS14; RPL10A; RPL10; RPS20; RPL7; RPL30; EIF3E; RPS6; RPL7A; RPL27A; RPS13; RPS25; RPS24; RPL6; RPL21; RPL4; RPLP1; RPS17; RPS15A; RPL13; RPL23A; RPL23; RPS15; RPS5
R-HSA-202733 Cell surface interactions at the vascular wall 3.84 9.45e-07 2.99e-05 16/42 SELL; GYPC; INPP5D; CD47; ATP1B3; CD74; CD99; DOK2; CD44; JAML; ITGB1; PTPN6; SELPLG; SPN; GRB2; ITGB2
R-HSA-5626467 RHO GTPases activate IQGAPs 3.78 3.08e-03 4.14e-02 6/16 CALM2; TUBA4A; IQGAP2; TUBA1B; CALM1
R-HSA-425393 Transport of inorganic cations/anions and amino acids/oligopeptides 3.78 3.08e-03 4.14e-02 6/16 CALM2; SLC1A4; SLC4A7; CALM1; SLC1A5
R-HSA-1799339 SRP-dependent cotranslational protein targeting to membrane 3.68 5.17e-14 5.73e-12 39/107 RPL11; RPS8; RPL5; RPS27; SSR2; RPS7; RPS27A; RPL37A; RPL32; RPL15; RPL9; RPL34; RPS3A; SPCS3; RPS23; RPS14; RPL10A; RPL10; RPS20; RPL7; RPL30; RPS6; SEC61B; RPL7A; RPL27A; RPS13; RPS25; RPS24; RPL6; RPL21; RPL4; RPLP1; RPS17; RPS15A; RPL13; RPL23A; RPL23; RPS15; RPS5
R-HSA-2408522 Selenoamino acid metabolism 3.67 5.64e-13 3.85e-11 36/99 RPL11; RPS8; RPL5; RPS27; RPS7; RPS27A; RPL37A; RPL32; RPL15; RPL9; RPL34; RPS3A; RPS23; RPS14; RPL10A; RPL10; RPS20; RPL7; RPL30; RPS6; RPL7A; RPL27A; RPS13; RPS25; RPS24; RPL6; RPL21; RPL4; RPLP1; RPS17; RPS15A; RPL13; RPL23A; RPL23; RPS15; RPS5
R-HSA-156827 L13a-mediated translational silencing of Ceruloplasmin expression 3.62 2.07e-13 2.04e-11 38/106 RPL11; RPS8; RPL5; RPS27; RPS7; RPS27A; RPL37A; RPL32; RPL15; RPL9; RPL34; RPS3A; RPS23; RPS14; RPL10A; RPL10; RPS20; RPL7; RPL30; PABPC1; EIF3E; RPS6; RPL7A; RPL27A; RPS13; RPS25; RPS24; RPL6; RPL21; RPL4; RPLP1; RPS17; RPS15A; RPL13; RPL23A; RPL23; RPS15; RPS5
R-HSA-72706 GTP hydrolysis and joining of the 60S ribosomal subunit 3.58 2.92e-13 2.59e-11 38/107 RPL11; RPS8; RPL5; RPS27; RPS7; RPS27A; EIF5B; RPL37A; RPL32; RPL15; RPL9; RPL34; RPS3A; RPS23; RPS14; RPL10A; RPL10; RPS20; RPL7; RPL30; EIF3E; RPS6; RPL7A; RPL27A; RPS13; RPS25; RPS24; RPL6; RPL21; RPL4; RPLP1; RPS17; RPS15A; RPL13; RPL23A; RPL23; RPS15; RPS5
R-HSA-72695 Formation of the ternary complex, and subsequently, the 43S complex 3.57 1.43e-06 4.23e-05 17/48 RPS8; RPS27; RPS7; RPS27A; RPS3A; RPS23; RPS14; RPS20; EIF3E; RPS6; RPS13; RPS25; RPS24; RPS17; RPS15A; RPS15; RPS5
R-HSA-927802 Nonsense-Mediated Decay (NMD) 3.52 1.14e-12 6.71e-11 37/106 RPL11; RPS8; RPL5; RPS27; RPS7; RPS27A; RPL37A; RPL32; RPL15; RPL9; RPL34; RPS3A; RPS23; RPS14; RPL10A; RPL10; RPS20; RPL7; RPL30; PABPC1; RPS6; RPL7A; RPL27A; RPS13; RPS25; RPS24; RPL6; RPL21; RPL4; RPLP1; RPS17; RPS15A; RPL13; RPL23A; RPL23; RPS15; RPS5
R-HSA-975957 Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) 3.52 1.14e-12 6.71e-11 37/106 RPL11; RPS8; RPL5; RPS27; RPS7; RPS27A; RPL37A; RPL32; RPL15; RPL9; RPL34; RPS3A; RPS23; RPS14; RPL10A; RPL10; RPS20; RPL7; RPL30; PABPC1; RPS6; RPL7A; RPL27A; RPS13; RPS25; RPS24; RPL6; RPL21; RPL4; RPLP1; RPS17; RPS15A; RPL13; RPL23A; RPL23; RPS15; RPS5
R-HSA-72613 Eukaryotic Translation Initiation 3.45 5.60e-13 3.85e-11 39/114 RPL11; RPS8; RPL5; RPS27; RPS7; RPS27A; EIF5B; RPL37A; RPL32; RPL15; RPL9; RPL34; RPS3A; RPS23; RPS14; RPL10A; RPL10; RPS20; RPL7; RPL30; PABPC1; EIF3E; RPS6; RPL7A; RPL27A; RPS13; RPS25; RPS24; RPL6; RPL21; RPL4; RPLP1; RPS17; RPS15A; RPL13; RPL23A; RPL23; RPS15; RPS5
R-HSA-72737 Cap-dependent Translation Initiation 3.45 5.60e-13 3.85e-11 39/114 RPL11; RPS8; RPL5; RPS27; RPS7; RPS27A; EIF5B; RPL37A; RPL32; RPL15; RPL9; RPL34; RPS3A; RPS23; RPS14; RPL10A; RPL10; RPS20; RPL7; RPL30; PABPC1; EIF3E; RPS6; RPL7A; RPL27A; RPS13; RPS25; RPS24; RPL6; RPL21; RPL4; RPLP1; RPS17; RPS15A; RPL13; RPL23A; RPL23; RPS15; RPS5
R-HSA-6785807 Interleukin-4 and Interleukin-13 signaling 3.45 3.92e-05 8.26e-04 13/38 TNFRSF1B; STAT1; PIM1; FSCN1; IL2RG; ANXA1; GATA3; VIM; ITGB1; RORA; JUNB; OSM; ITGB2
R-HSA-512988 Interleukin-3, Interleukin-5 and GM-CSF signaling 3.36 1.53e-03 2.36e-02 8/24 RPS27A; INPP5D; IL2RG; YWHAZ; IL2RA; PTPN6; GRB2; IL2RB
R-HSA-983695 Antigen activates B Cell Receptor (BCR) leading to generation of second messengers 3.36 3.02e-03 4.14e-02 7/21 CALM2; DAPP1; PTPN6; CALM1; GRB2; CD79A
R-HSA-72649 Translation initiation complex formation 3.30 2.62e-06 7.04e-05 18/55 RPS8; RPS27; RPS7; RPS27A; RPS3A; RPS23; RPS14; RPS20; PABPC1; EIF3E; RPS6; RPS13; RPS25; RPS24; RPS17; RPS15A; RPS15; RPS5
R-HSA-500792 GPCR ligand binding 3.27 1.41e-04 2.71e-03 12/37 XCL1; CXCL10; F2R; HRH2; ANXA1; LPAR6; GPR183; PTGER2; CCL5; CCR7; S1PR4; PTGIR
R-HSA-72662 Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S 3.24 3.52e-06 8.90e-05 18/56 RPS8; RPS27; RPS7; RPS27A; RPS3A; RPS23; RPS14; RPS20; PABPC1; EIF3E; RPS6; RPS13; RPS25; RPS24; RPS17; RPS15A; RPS15; RPS5
R-HSA-397014 Muscle contraction 3.20 9.66e-05 1.90e-03 13/41 ATP2B4; CALM2; TTN; ATP1B3; MYL5; ITGA1; ANXA1; VIM; CALM1; ANXA2; MYL12A; TPM4
R-HSA-114608 Platelet degranulation 3.15 3.40e-05 7.34e-04 15/48 CALM2; TTN; TUBA4A; TEX264; ANXA5; FAM3C; FLNA; FAM49B; HSPA5; CTSW; SRGN; CD63; CALM1; ACTN4
R-HSA-72702 Ribosomal scanning and start codon recognition 3.12 1.19e-05 2.86e-04 17/55 RPS8; RPS27; RPS7; RPS27A; RPS3A; RPS23; RPS14; RPS20; EIF3E; RPS6; RPS13; RPS25; RPS24; RPS17; RPS15A; RPS15; RPS5
R-HSA-168273 Influenza Viral RNA Transcription and Replication 3.08 1.02e-10 5.66e-09 37/121 RPL11; RPS8; RPL5; RPS27; RPS7; RPS27A; RPL37A; RPL32; RPL15; RPL9; GRSF1; RPL34; RPS3A; RPS23; RPS14; RPL10A; RPL10; RPS20; RPL7; RPL30; RPS6; RPL7A; RPL27A; RPS13; RPS25; RPS24; RPL6; RPL21; RPL4; RPLP1; RPS17; RPS15A; RPL13; RPL23A; RPL23; RPS15; RPS5
R-HSA-168255 Influenza Life Cycle 2.95 2.49e-10 1.30e-08 38/130 RPL11; RPS8; RPL5; RPS27; RPS7; RPS27A; RPL37A; RPL32; RPL15; RPL9; GRSF1; RPL34; RPS3A; RPS23; RPS14; RPL10A; RPL10; RPS20; RPL7; RPL30; RPS6; CLTA; RPL7A; RPL27A; RPS13; RPS25; RPS24; RPL6; RPL21; RPL4; RPLP1; RPS17; RPS15A; RPL13; RPL23A; RPL23; RPS15; RPS5
R-HSA-76005 Response to elevated platelet cytosolic Ca2+ 2.91 9.60e-05 1.90e-03 15/52 CALM2; TTN; TUBA4A; TEX264; ANXA5; FAM3C; FLNA; FAM49B; HSPA5; CTSW; SRGN; CD63; CALM1; ACTN4
R-HSA-168254 Influenza Infection 2.76 2.10e-09 9.32e-08 38/139 RPL11; RPS8; RPL5; RPS27; RPS7; RPS27A; RPL37A; RPL32; RPL15; RPL9; GRSF1; RPL34; RPS3A; RPS23; RPS14; RPL10A; RPL10; RPS20; RPL7; RPL30; RPS6; CLTA; RPL7A; RPL27A; RPS13; RPS25; RPS24; RPL6; RPL21; RPL4; RPLP1; RPS17; RPS15A; RPL13; RPL23A; RPL23; RPS15; RPS5
R-HSA-877300 Interferon gamma signaling 2.63 1.29e-03 2.08e-02 12/46 GBP2; GBP5; STAT1; HLA-F; HLA-DRA; HLA-DQA1; HLA-DQB1; CD44; PTPN6; IFNG; B2M; MT2A
R-HSA-9010553 Regulation of expression of SLITs and ROBOs 2.61 1.17e-08 4.92e-07 38/147 RPL11; RPS8; RPL5; RPS27; RPS7; RPS27A; RPL37A; RPL32; RPL15; RPL9; RPL34; RPS3A; RPS23; RPS14; RPL10A; RPL10; RPS20; RPL7; RPL30; PABPC1; RPS6; RPL7A; RPL27A; RPS13; RPS25; RPS24; RPL6; RPL21; PSME2; RPL4; RPLP1; RPS17; RPS15A; RPL13; RPL23A; RPL23; RPS15; RPS5
R-HSA-6791226 Major pathway of rRNA processing in the nucleolus and cytosol 2.36 2.99e-07 1.06e-05 37/158 RPL11; RPS8; RPL5; RPS27; RPS7; RPS27A; RPL37A; RPL32; RPL15; RPL9; RPL34; RPS3A; RPS23; RPS14; RPL10A; RPL10; ERI1; RPS20; RPL7; RPL30; RPS6; RPL7A; RPL27A; RPS13; RPS25; RPS24; RPL6; RPL21; RPL4; RPLP1; RPS17; RPS15A; RPL13; RPL23A; RPL23; RPS15; RPS5
R-HSA-376176 Signaling by ROBO receptors 2.36 1.51e-07 5.58e-06 39/167 RPL11; RPS8; RPL5; RPS27; RPS7; RPS27A; RPL37A; RPL32; RPL15; RPL9; RPL34; RPS3A; RPS23; RPS14; RPL10A; RPL10; RPS20; RPL7; RPL30; PABPC1; RPS6; RPL7A; RPL27A; RPS13; RPS25; RPS24; NELL2; RPL6; RPL21; PSME2; RPL4; RPLP1; RPS17; RPS15A; RPL13; RPL23A; RPL23; RPS15; RPS5
R-HSA-422475 Axon guidance 2.24 1.17e-09 5.44e-08 57/257 RPL11; RPS8; RPL5; RPS27; ARPC5; RPS7; RPS27A; RPL37A; TUBA4A; RPL32; RPL15; SIAH2; RPL9; RPL34; RPS3A; ITGA1; RPS23; RPS14; RPL10A; HSP90AB1; MSN; RPL10; DOK2; FGFR1; RPS20; SDCBP; RPL7; RPL30; PABPC1; RPS6; CLTA; RPL7A; RPL27A; RPS13; RDX; RPS25; ITGB1; RPS24; NELL2; TUBA1B; RPL6; RPL21; PSME2; RPS6KA5; RPL4; RPLP1; RPS17; RPS15A; RPL13; RPL23A; RPL23; GRB2; MYL12A; RPS15; RPS5; TIAM1; COL6A2
R-HSA-449147 Signaling by Interleukins 2.23 3.11e-08 1.20e-06 48/217 TNFRSF1B; RPS27A; PTPN4; PTPN18; STAT1; INPP5D; CISH; CXCL10; IL7R; SKP1; HAVCR2; PIM1; FSCN1; MSN; IL2RG; YWHAZ; ANXA1; CASP1; IL10RA; IL2RA; GATA3; VIM; ITGB1; HNRNPF; NFKB2; PTPN6; IFNG; PSME2; NFKBIA; RPS6KA5; ANXA2; RORA; IL16; IL32; IL21R; LGALS9; CCL5; CCL3; CCL4; CCL3L3; CCL4L2; GRB2; P4HB; JUNB; OSM; IL2RB; ITGB2
R-HSA-76002 Platelet activation, signaling and aggregation 2.23 1.48e-04 2.79e-03 23/104 CALM2; TTN; TUBA4A; TEX264; ANXA5; F2R; FAM3C; FLNA; YWHAZ; FAM49B; HSPA5; RASGRP2; CTSW; APBB1IP; SRGN; PTPN6; CD63; CALM1; LAT; ARRB2; GRB2; ACTN4
R-HSA-418594 G alpha (i) signalling events 2.22 2.15e-03 3.08e-02 15/68 DHRS3; RGS1; CALM2; CXCL10; ANXA1; RGS10; GPR183; CALM1; CCL5; CCL4; CCL4L2; CCR7; S1PR4
R-HSA-8868773 rRNA processing in the nucleus and cytosol 2.22 1.52e-06 4.35e-05 37/168 RPL11; RPS8; RPL5; RPS27; RPS7; RPS27A; RPL37A; RPL32; RPL15; RPL9; RPL34; RPS3A; RPS23; RPS14; RPL10A; RPL10; ERI1; RPS20; RPL7; RPL30; RPS6; RPL7A; RPL27A; RPS13; RPS25; RPS24; RPL6; RPL21; RPL4; RPLP1; RPS17; RPS15A; RPL13; RPL23A; RPL23; RPS15; RPS5
R-HSA-72312 rRNA processing 2.13 4.30e-06 1.06e-04 37/175 RPL11; RPS8; RPL5; RPS27; RPS7; RPS27A; RPL37A; RPL32; RPL15; RPL9; RPL34; RPS3A; RPS23; RPS14; RPL10A; RPL10; ERI1; RPS20; RPL7; RPL30; RPS6; RPL7A; RPL27A; RPS13; RPS25; RPS24; RPL6; RPL21; RPL4; RPLP1; RPS17; RPS15A; RPL13; RPL23A; RPL23; RPS15; RPS5
R-HSA-109582 Hemostasis 2.12 4.25e-07 1.45e-05 45/214 S100A10; SELL; ATP2B4; CALM2; GYPC; TTN; TUBA4A; INPP5D; TEX264; CD47; ATP1B3; ANXA5; ITGA1; F2R; CD74; SERPINB6; FAM3C; CD99; FLNA; DOK2; YWHAZ; FAM49B; HSPA5; CD44; RASGRP2; CTSW; JAML; GATA3; APBB1IP; ITGB1; SRGN; PTPN6; TUBA1B; CD63; SELPLG; CALM1; ANXA2; LAT; SPN; ARRB2; GRB2; ACTN4; PTGIR; ITGB2
R-HSA-388396 GPCR downstream signalling 2.03 2.76e-04 4.80e-03 26/129 DHRS3; XCL1; RGS1; CALM2; CXCL10; F2R; REEP5; HRH2; ANXA1; RASGRP2; RGS10; LPAR6; GPR183; PTGER2; CALM1; ARRB2; CCL5; CCL4; CCL4L2; CCR7; GRB2; S1PR4; PTGIR; TIAM1
R-HSA-372790 Signaling by GPCR 2.00 3.57e-04 5.97e-03 26/131 DHRS3; XCL1; RGS1; CALM2; CXCL10; F2R; REEP5; HRH2; ANXA1; RASGRP2; RGS10; LPAR6; GPR183; PTGER2; CALM1; ARRB2; CCL5; CCL4; CCL4L2; CCR7; GRB2; S1PR4; PTGIR; TIAM1
Factor 5 : 46 significant Reactome pathways
GeneSet description enrichRatio pValue FDR GeneRatio geneSymbols
R-HSA-156902 Peptide chain elongation 17.70 0.00e+00 0.00e+00 25/85 RPS8; RPSA; RPL9; RPS3A; RPS18; RPL10A; RPS12; RPL8; RPS6; RPL35; RPL12; RPL7A; RPS3; RPS24; RPLP0; RPS17; RPS2; RPS15; RPL18A; RPS16; RPL13A; RPS9; RPL28; RPS5; RPL3
R-HSA-192823 Viral mRNA Translation 17.70 0.00e+00 0.00e+00 25/85 RPS8; RPSA; RPL9; RPS3A; RPS18; RPL10A; RPS12; RPL8; RPS6; RPL35; RPL12; RPL7A; RPS3; RPS24; RPLP0; RPS17; RPS2; RPS15; RPL18A; RPS16; RPL13A; RPS9; RPL28; RPS5; RPL3
R-HSA-2408557 Selenocysteine synthesis 17.70 0.00e+00 0.00e+00 25/85 RPS8; RPSA; RPL9; RPS3A; RPS18; RPL10A; RPS12; RPL8; RPS6; RPL35; RPL12; RPL7A; RPS3; RPS24; RPLP0; RPS17; RPS2; RPS15; RPL18A; RPS16; RPL13A; RPS9; RPL28; RPS5; RPL3
R-HSA-72695 Formation of the ternary complex, and subsequently, the 43S complex 17.50 8.66e-15 2.84e-13 14/48 RPS8; RPSA; RPS3A; RPS18; RPS12; RPS6; RPS3; RPS24; RPS17; RPS2; RPS15; RPS16; RPS9; RPS5
R-HSA-156842 Eukaryotic Translation Elongation 17.30 0.00e+00 0.00e+00 25/87 RPS8; RPSA; RPL9; RPS3A; RPS18; RPL10A; RPS12; RPL8; RPS6; RPL35; RPL12; RPL7A; RPS3; RPS24; RPLP0; RPS17; RPS2; RPS15; RPL18A; RPS16; RPL13A; RPS9; RPL28; RPS5; RPL3
R-HSA-72764 Eukaryotic Translation Termination 17.10 0.00e+00 0.00e+00 25/88 RPS8; RPSA; RPL9; RPS3A; RPS18; RPL10A; RPS12; RPL8; RPS6; RPL35; RPL12; RPL7A; RPS3; RPS24; RPLP0; RPS17; RPS2; RPS15; RPL18A; RPS16; RPL13A; RPS9; RPL28; RPS5; RPL3
R-HSA-975956 Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) 16.90 0.00e+00 0.00e+00 25/89 RPS8; RPSA; RPL9; RPS3A; RPS18; RPL10A; RPS12; RPL8; RPS6; RPL35; RPL12; RPL7A; RPS3; RPS24; RPLP0; RPS17; RPS2; RPS15; RPL18A; RPS16; RPL13A; RPS9; RPL28; RPS5; RPL3
R-HSA-983170 Antigen Presentation: Folding, assembly and peptide loading of class I MHC 15.80 1.06e-05 2.85e-04 5/19 HLA-A; HLA-E; HLA-C; HLA-B; B2M
R-HSA-72689 Formation of a pool of free 40S subunits 15.60 0.00e+00 0.00e+00 25/96 RPS8; RPSA; RPL9; RPS3A; RPS18; RPL10A; RPS12; RPL8; RPS6; RPL35; RPL12; RPL7A; RPS3; RPS24; RPLP0; RPS17; RPS2; RPS15; RPL18A; RPS16; RPL13A; RPS9; RPL28; RPS5; RPL3
R-HSA-72649 Translation initiation complex formation 15.30 7.17e-14 2.05e-12 14/55 RPS8; RPSA; RPS3A; RPS18; RPS12; RPS6; RPS3; RPS24; RPS17; RPS2; RPS15; RPS16; RPS9; RPS5
R-HSA-72702 Ribosomal scanning and start codon recognition 15.30 7.17e-14 2.05e-12 14/55 RPS8; RPSA; RPS3A; RPS18; RPS12; RPS6; RPS3; RPS24; RPS17; RPS2; RPS15; RPS16; RPS9; RPS5
R-HSA-2408522 Selenoamino acid metabolism 15.20 0.00e+00 0.00e+00 25/99 RPS8; RPSA; RPL9; RPS3A; RPS18; RPL10A; RPS12; RPL8; RPS6; RPL35; RPL12; RPL7A; RPS3; RPS24; RPLP0; RPS17; RPS2; RPS15; RPL18A; RPS16; RPL13A; RPS9; RPL28; RPS5; RPL3
R-HSA-3928662 EPHB-mediated forward signaling 15.00 1.40e-05 3.64e-04 5/20 ARPC2; ACTB; ARPC1B; CFL1; ACTG1
R-HSA-72662 Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S 15.00 9.46e-14 2.62e-12 14/56 RPS8; RPSA; RPS3A; RPS18; RPS12; RPS6; RPS3; RPS24; RPS17; RPS2; RPS15; RPS16; RPS9; RPS5
R-HSA-157858 Gap junction trafficking and regulation 15.00 8.71e-04 1.82e-02 3/12 ACTB; TUBA1B; ACTG1
R-HSA-190828 Gap junction trafficking 15.00 8.71e-04 1.82e-02 3/12 ACTB; TUBA1B; ACTG1
R-HSA-156827 L13a-mediated translational silencing of Ceruloplasmin expression 14.20 0.00e+00 0.00e+00 25/106 RPS8; RPSA; RPL9; RPS3A; RPS18; RPL10A; RPS12; RPL8; RPS6; RPL35; RPL12; RPL7A; RPS3; RPS24; RPLP0; RPS17; RPS2; RPS15; RPL18A; RPS16; RPL13A; RPS9; RPL28; RPS5; RPL3
R-HSA-927802 Nonsense-Mediated Decay (NMD) 14.20 0.00e+00 0.00e+00 25/106 RPS8; RPSA; RPL9; RPS3A; RPS18; RPL10A; RPS12; RPL8; RPS6; RPL35; RPL12; RPL7A; RPS3; RPS24; RPLP0; RPS17; RPS2; RPS15; RPL18A; RPS16; RPL13A; RPS9; RPL28; RPS5; RPL3
R-HSA-975957 Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) 14.20 0.00e+00 0.00e+00 25/106 RPS8; RPSA; RPL9; RPS3A; RPS18; RPL10A; RPS12; RPL8; RPS6; RPL35; RPL12; RPL7A; RPS3; RPS24; RPLP0; RPS17; RPS2; RPS15; RPL18A; RPS16; RPL13A; RPS9; RPL28; RPS5; RPL3
R-HSA-72706 GTP hydrolysis and joining of the 60S ribosomal subunit 14.00 0.00e+00 0.00e+00 25/107 RPS8; RPSA; RPL9; RPS3A; RPS18; RPL10A; RPS12; RPL8; RPS6; RPL35; RPL12; RPL7A; RPS3; RPS24; RPLP0; RPS17; RPS2; RPS15; RPL18A; RPS16; RPL13A; RPS9; RPL28; RPS5; RPL3
R-HSA-1799339 SRP-dependent cotranslational protein targeting to membrane 14.00 0.00e+00 0.00e+00 25/107 RPS8; RPSA; RPL9; RPS3A; RPS18; RPL10A; RPS12; RPL8; RPS6; RPL35; RPL12; RPL7A; RPS3; RPS24; RPLP0; RPS17; RPS2; RPS15; RPL18A; RPS16; RPL13A; RPS9; RPL28; RPS5; RPL3
R-HSA-72613 Eukaryotic Translation Initiation 13.20 0.00e+00 0.00e+00 25/114 RPS8; RPSA; RPL9; RPS3A; RPS18; RPL10A; RPS12; RPL8; RPS6; RPL35; RPL12; RPL7A; RPS3; RPS24; RPLP0; RPS17; RPS2; RPS15; RPL18A; RPS16; RPL13A; RPS9; RPL28; RPS5; RPL3
R-HSA-72737 Cap-dependent Translation Initiation 13.20 0.00e+00 0.00e+00 25/114 RPS8; RPSA; RPL9; RPS3A; RPS18; RPL10A; RPS12; RPL8; RPS6; RPL35; RPL12; RPL7A; RPS3; RPS24; RPLP0; RPS17; RPS2; RPS15; RPL18A; RPS16; RPL13A; RPS9; RPL28; RPS5; RPL3
R-HSA-168273 Influenza Viral RNA Transcription and Replication 12.40 0.00e+00 0.00e+00 25/121 RPS8; RPSA; RPL9; RPS3A; RPS18; RPL10A; RPS12; RPL8; RPS6; RPL35; RPL12; RPL7A; RPS3; RPS24; RPLP0; RPS17; RPS2; RPS15; RPL18A; RPS16; RPL13A; RPS9; RPL28; RPS5; RPL3
R-HSA-168255 Influenza Life Cycle 11.50 0.00e+00 0.00e+00 25/130 RPS8; RPSA; RPL9; RPS3A; RPS18; RPL10A; RPS12; RPL8; RPS6; RPL35; RPL12; RPL7A; RPS3; RPS24; RPLP0; RPS17; RPS2; RPS15; RPL18A; RPS16; RPL13A; RPS9; RPL28; RPS5; RPL3
R-HSA-5626467 RHO GTPases activate IQGAPs 11.30 2.11e-03 4.07e-02 3/16 ACTB; TUBA1B; ACTG1
R-HSA-168254 Influenza Infection 10.80 0.00e+00 0.00e+00 25/139 RPS8; RPSA; RPL9; RPS3A; RPS18; RPL10A; RPS12; RPL8; RPS6; RPL35; RPL12; RPL7A; RPS3; RPS24; RPLP0; RPS17; RPS2; RPS15; RPL18A; RPS16; RPL13A; RPS9; RPL28; RPS5; RPL3
R-HSA-9010553 Regulation of expression of SLITs and ROBOs 10.20 0.00e+00 0.00e+00 25/147 RPS8; RPSA; RPL9; RPS3A; RPS18; RPL10A; RPS12; RPL8; RPS6; RPL35; RPL12; RPL7A; RPS3; RPS24; RPLP0; RPS17; RPS2; RPS15; RPL18A; RPS16; RPL13A; RPS9; RPL28; RPS5; RPL3
R-HSA-5663213 RHO GTPases Activate WASPs and WAVEs 9.61 6.80e-04 1.55e-02 4/25 ARPC2; ACTB; ARPC1B; ACTG1
R-HSA-6791226 Major pathway of rRNA processing in the nucleolus and cytosol 9.50 0.00e+00 0.00e+00 25/158 RPS8; RPSA; RPL9; RPS3A; RPS18; RPL10A; RPS12; RPL8; RPS6; RPL35; RPL12; RPL7A; RPS3; RPS24; RPLP0; RPS17; RPS2; RPS15; RPL18A; RPS16; RPL13A; RPS9; RPL28; RPS5; RPL3
R-HSA-2682334 EPH-Ephrin signaling 9.48 3.06e-05 7.73e-04 6/38 ARPC2; ACTB; ARPC1B; CFL1; MYL6; ACTG1
R-HSA-376176 Signaling by ROBO receptors 9.35 0.00e+00 0.00e+00 26/167 RPS8; RPSA; RPL9; RPS3A; RPS18; RPL10A; RPS12; RPL8; RPS6; RPL35; RPL12; RPL7A; RPS3; RPS24; RPLP0; RPS17; RPS2; PFN1; RPS15; RPL18A; RPS16; RPL13A; RPS9; RPL28; RPS5; RPL3
R-HSA-8868773 rRNA processing in the nucleus and cytosol 8.93 0.00e+00 0.00e+00 25/168 RPS8; RPSA; RPL9; RPS3A; RPS18; RPL10A; RPS12; RPL8; RPS6; RPL35; RPL12; RPL7A; RPS3; RPS24; RPLP0; RPS17; RPS2; RPS15; RPL18A; RPS16; RPL13A; RPS9; RPL28; RPS5; RPL3
R-HSA-72312 rRNA processing 8.58 0.00e+00 0.00e+00 25/175 RPS8; RPSA; RPL9; RPS3A; RPS18; RPL10A; RPS12; RPL8; RPS6; RPL35; RPL12; RPL7A; RPS3; RPS24; RPLP0; RPS17; RPS2; RPS15; RPL18A; RPS16; RPL13A; RPS9; RPL28; RPS5; RPL3
R-HSA-2029482 Regulation of actin dynamics for phagocytic cup formation 8.11 3.16e-04 7.77e-03 5/37 ARPC2; ACTB; ARPC1B; CFL1; ACTG1
R-HSA-198933 Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell 7.90 3.59e-04 8.37e-03 5/38 HLA-A; HLA-E; HLA-C; HLA-B; B2M
R-HSA-422475 Axon guidance 7.71 0.00e+00 0.00e+00 33/257 RPS8; ARPC2; RPSA; RPL9; RPS3A; RPS18; RPL10A; RPS12; ACTB; ARPC1B; RPL8; RPS6; RPL35; RPL12; RPL7A; CFL1; RPS3; RPS24; TUBA1B; MYL6; RPLP0; RPS17; RPS2; PFN1; ACTG1; RPS15; RPL18A; RPS16; RPL13A; RPS9; RPL28; RPS5; RPL3
R-HSA-909733 Interferon alpha/beta signaling 7.50 1.77e-03 3.57e-02 4/32 HLA-A; HLA-E; HLA-C; HLA-B
R-HSA-71291 Metabolism of amino acids and derivatives 7.08 4.44e-16 1.51e-14 25/212 RPS8; RPSA; RPL9; RPS3A; RPS18; RPL10A; RPS12; RPL8; RPS6; RPL35; RPL12; RPL7A; RPS3; RPS24; RPLP0; RPS17; RPS2; RPS15; RPL18A; RPS16; RPL13A; RPS9; RPL28; RPS5; RPL3
R-HSA-2029480 Fcgamma receptor (FCGR) dependent phagocytosis 6.82 7.19e-04 1.59e-02 5/44 ARPC2; ACTB; ARPC1B; CFL1; ACTG1
R-HSA-877300 Interferon gamma signaling 6.53 8.85e-04 1.82e-02 5/46 HLA-A; HLA-E; HLA-C; HLA-B; B2M
R-HSA-1266738 Developmental Biology 5.94 0.00e+00 0.00e+00 35/354 RPS8; ARPC2; RPSA; RPL9; H2AFZ; RPS3A; RPS18; RPL10A; RPS12; ACTB; H2AFV; ARPC1B; RPL8; RPS6; RPL35; RPL12; RPL7A; CFL1; RPS3; RPS24; TUBA1B; MYL6; RPLP0; RPS17; RPS2; PFN1; ACTG1; RPS15; RPL18A; RPS16; RPL13A; RPS9; RPL28; RPS5; RPL3
R-HSA-72766 Translation 5.89 1.01e-14 3.20e-13 26/265 RPS8; RPSA; RPL9; RPS3A; RPS18; RPL10A; RPS12; RPL8; RPS6; RPL35; RPL12; RPL7A; CARS; RPS3; RPS24; RPLP0; RPS17; RPS2; RPS15; RPL18A; RPS16; RPL13A; RPS9; RPL28; RPS5; RPL3
R-HSA-5663205 Infectious disease 5.30 3.69e-14 1.13e-12 27/306 RPS8; RPSA; RPL9; RPS3A; RPS18; RPL10A; RPS12; PPIA; RPL8; RPS6; RPL35; RPL12; RPL7A; RPS3; RPS24; RPLP0; B2M; RPS17; RPS2; RPS15; RPL18A; RPS16; RPL13A; RPS9; RPL28; RPS5; RPL3
R-HSA-195258 RHO GTPase Effectors 3.62 3.44e-04 8.23e-03 10/166 ARPC2; H2AFZ; ACTB; H2AFV; ARPC1B; CFL1; TUBA1B; MYL6; PFN1; ACTG1
R-HSA-194315 Signaling by Rho GTPases 2.90 1.93e-03 3.80e-02 10/207 ARPC2; H2AFZ; ACTB; H2AFV; ARPC1B; CFL1; TUBA1B; MYL6; PFN1; ACTG1
Factor 6 : 131 significant Reactome pathways
GeneSet description enrichRatio pValue FDR GeneRatio geneSymbols
R-HSA-176974 Unwinding of DNA 20.00 7.72e-14 2.97e-12 10/10 MCM6; MCM2; MCM3; MCM7; GINS4; MCM4; GINS2; MCM8; CDC45; MCM5
R-HSA-69190 DNA strand elongation 18.40 0.00e+00 0.00e+00 23/25 RPA2; MCM6; MCM2; RFC4; RFC1; MCM3; RPA3; RFC2; MCM7; GINS4; MCM4; FEN1; POLA2; POLD3; PRIM1; RFC5; RFC3; GINS2; PCNA; MCM8; LIG1; CDC45; MCM5
R-HSA-174411 Polymerase switching on the C-strand of the telomere 18.00 1.55e-11 3.71e-10 9/10 RFC4; RFC1; RFC2; POLA2; POLD3; PRIM1; RFC5; RFC3; PCNA
R-HSA-69091 Polymerase switching 18.00 1.55e-11 3.71e-10 9/10 RFC4; RFC1; RFC2; POLA2; POLD3; PRIM1; RFC5; RFC3; PCNA
R-HSA-69109 Leading Strand Synthesis 18.00 1.55e-11 3.71e-10 9/10 RFC4; RFC1; RFC2; POLA2; POLD3; PRIM1; RFC5; RFC3; PCNA
R-HSA-69186 Lagging Strand Synthesis 17.30 7.77e-16 3.44e-14 13/15 RPA2; RFC4; RFC1; RPA3; RFC2; FEN1; POLA2; POLD3; PRIM1; RFC5; RFC3; PCNA; LIG1
R-HSA-69183 Processive synthesis on the lagging strand 16.00 1.39e-09 2.62e-08 8/10 RPA2; RPA3; FEN1; POLA2; POLD3; PRIM1; PCNA; LIG1
R-HSA-176187 Activation of ATR in response to replication stress 15.60 0.00e+00 0.00e+00 21/27 RPA2; CLSPN; MCM6; MCM2; RFC4; MCM3; RPA3; RFC2; MCM7; MCM4; RAD9A; CHEK1; MCM10; CDK2; RFC5; RFC3; ORC6; CDC6; MCM8; CDC45; MCM5
R-HSA-174417 Telomere C-strand (Lagging Strand) Synthesis 15.30 1.62e-14 6.53e-13 13/17 RPA2; RFC4; RFC1; RPA3; RFC2; FEN1; POLA2; POLD3; PRIM1; RFC5; RFC3; PCNA; LIG1
R-HSA-68962 Activation of the pre-replicative complex 15.00 0.00e+00 0.00e+00 18/24 RPA2; MCM6; MCM2; GMNN; MCM3; RPA3; MCM7; MCM4; POLA2; MCM10; CDK2; PRIM1; ORC6; CDT1; CDC6; MCM8; CDC45; MCM5
R-HSA-5358565 Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) 14.00 7.38e-08 1.04e-06 7/10 RPA2; MSH2; MSH6; RPA3; POLD3; PCNA; LIG1
R-HSA-5651801 PCNA-Dependent Long Patch Base Excision Repair 13.80 1.28e-11 3.34e-10 11/16 RPA2; RFC4; RFC1; RPA3; RFC2; FEN1; POLD3; RFC5; RFC3; PCNA; LIG1
R-HSA-5358508 Mismatch Repair 12.70 1.94e-07 2.61e-06 7/11 RPA2; MSH2; MSH6; RPA3; POLD3; PCNA; LIG1
R-HSA-5693579 Homologous DNA Pairing and Strand Exchange 12.70 0.00e+00 0.00e+00 19/30 RPA2; BARD1; TOPBP1; RFC4; RPA3; RFC2; XRCC2; RMI1; RAD9A; CHEK1; RAD51AP1; RFC5; BRCA2; RFC3; RAD51; BLM; RMI2; BRCA1; RBBP8
R-HSA-539107 Activation of E2F1 target genes at G1/S 12.60 6.39e-12 1.89e-10 12/19 RRM2; DHFR; FBXO5; TFDP1; CDT1; CDC6; TK1; TYMS; PCNA; E2F1; CCNE1; CDC45
R-HSA-69205 G1/S-Specific Transcription 12.60 6.39e-12 1.89e-10 12/19 RRM2; DHFR; FBXO5; TFDP1; CDT1; CDC6; TK1; TYMS; PCNA; E2F1; CCNE1; CDC45
R-HSA-5693616 Presynaptic phase of homologous DNA pairing and strand exchange 12.40 0.00e+00 0.00e+00 18/29 RPA2; BARD1; TOPBP1; RFC4; RPA3; RFC2; XRCC2; RMI1; RAD9A; CHEK1; RFC5; BRCA2; RFC3; RAD51; BLM; RMI2; BRCA1; RBBP8
R-HSA-180786 Extension of Telomeres 12.40 1.16e-12 3.95e-11 13/21 RPA2; RFC4; RFC1; RPA3; RFC2; FEN1; POLA2; POLD3; PRIM1; RFC5; RFC3; PCNA; LIG1
R-HSA-110373 Resolution of AP sites via the multiple-nucleotide patch replacement pathway 12.20 8.55e-11 1.80e-09 11/18 RPA2; RFC4; RFC1; RPA3; RFC2; FEN1; POLD3; RFC5; RFC3; PCNA; LIG1
R-HSA-156711 Polo-like kinase mediated events 12.00 2.56e-06 2.94e-05 6/10 CENPF; CCNB1; CCNB2; PKMYT1; PLK1; MYBL2
R-HSA-5358606 Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) 12.00 2.56e-06 2.94e-05 6/10 RPA2; MSH2; RPA3; POLD3; PCNA; LIG1
R-HSA-5693554 Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) 11.80 1.10e-09 2.12e-08 10/17 BARD1; XRCC2; RMI1; RAD51AP1; BRCA2; RAD51; BLM; RMI2; BRCA1; RBBP8
R-HSA-5685938 HDR through Single Strand Annealing (SSA) 11.50 8.35e-14 3.08e-12 15/26 RPA2; BARD1; TOPBP1; RFC4; RPA3; RFC2; RMI1; RAD9A; RFC5; RFC3; RAD51; BLM; RMI2; BRCA1; RBBP8
R-HSA-110312 Translesion synthesis by REV1 11.30 1.36e-08 2.19e-07 9/16 RPA2; RFC4; RFC1; RPA3; RFC2; RFC5; RFC3; UBB; PCNA
R-HSA-5656121 Translesion synthesis by POLI 11.30 1.36e-08 2.19e-07 9/16 RPA2; RFC4; RFC1; RPA3; RFC2; RFC5; RFC3; UBB; PCNA
R-HSA-5693537 Resolution of D-Loop Structures 11.10 2.37e-09 4.29e-08 10/18 BARD1; XRCC2; RMI1; RAD51AP1; BRCA2; RAD51; BLM; RMI2; BRCA1; RBBP8
R-HSA-5693568 Resolution of D-loop Structures through Holliday Junction Intermediates 11.10 2.37e-09 4.29e-08 10/18 BARD1; XRCC2; RMI1; RAD51AP1; BRCA2; RAD51; BLM; RMI2; BRCA1; RBBP8
R-HSA-5696397 Gap-filling DNA repair synthesis and ligation in GG-NER 11.00 4.13e-10 8.51e-09 11/20 RPA2; RFC4; RFC1; RPA3; RFC2; POLD3; RFC5; RFC3; UBB; PCNA; LIG1
R-HSA-5685942 HDR through Homologous Recombination (HRR) 11.00 0.00e+00 0.00e+00 23/42 RPA2; BARD1; TOPBP1; RFC4; RFC1; RPA3; RFC2; XRCC2; RMI1; RAD9A; POLD3; CHEK1; RAD51AP1; RFC5; BRCA2; RFC3; RAD51; BLM; RMI2; UBB; BRCA1; RBBP8; PCNA
R-HSA-140342 Apoptosis induced DNA fragmentation 10.90 5.40e-06 5.98e-05 6/11 HMGB2; HIST1H1A; HIST1H1C; HIST1H1E; HIST1H1D; HIST1H1B
R-HSA-211227 Activation of DNA fragmentation factor 10.90 5.40e-06 5.98e-05 6/11 HMGB2; HIST1H1A; HIST1H1C; HIST1H1E; HIST1H1D; HIST1H1B
R-HSA-5655862 Translesion synthesis by POLK 10.60 2.77e-08 4.23e-07 9/17 RPA2; RFC4; RFC1; RPA3; RFC2; RFC5; RFC3; UBB; PCNA
R-HSA-912446 Meiotic recombination 10.00 4.74e-11 1.05e-09 13/26 RPA2; HIST2H2AC; MND1; HIST1H4C; RPA3; CDK2; CDK4; BRCA2; RAD51; BLM; BRCA1; H3F3B; RBBP8
R-HSA-110320 Translesion Synthesis by POLH 10.00 5.30e-08 7.57e-07 9/18 RPA2; RFC4; RFC1; RPA3; RFC2; RFC5; RFC3; UBB; PCNA
R-HSA-113510 E2F mediated regulation of DNA replication 10.00 1.78e-06 2.19e-05 7/14 CCNB1; POLA2; PRIM1; TFDP1; ORC6; MCM8; E2F1
R-HSA-110314 Recognition of DNA damage by PCNA-containing replication complex 9.24 8.98e-10 1.77e-08 12/26 RPA2; USP1; DTL; RFC4; RFC1; RPA3; RFC2; POLD3; RFC5; RFC3; UBB; PCNA
R-HSA-5656169 Termination of translesion DNA synthesis 9.17 5.14e-09 8.77e-08 11/24 RPA2; RFC4; RFC1; RPA3; RFC2; POLD3; RFC5; RFC3; KIAA0101; UBB; PCNA
R-HSA-157579 Telomere Maintenance 9.10 8.22e-12 2.21e-10 15/33 RPA2; HIST2H2AC; RFC4; RFC1; HIST1H4C; RPA3; RFC2; FEN1; POLA2; POLD3; PRIM1; RFC5; RFC3; PCNA; LIG1
R-HSA-73884 Base Excision Repair 8.58 2.59e-09 4.50e-08 12/28 RPA2; RFC4; RFC1; RPA3; RFC2; FEN1; POLD3; UNG; RFC5; RFC3; PCNA; LIG1
R-HSA-73933 Resolution of Abasic Sites (AP sites) 8.58 2.59e-09 4.50e-08 12/28 RPA2; RFC4; RFC1; RPA3; RFC2; FEN1; POLD3; UNG; RFC5; RFC3; PCNA; LIG1
R-HSA-5334118 DNA methylation 8.34 1.76e-04 1.67e-03 5/12 HIST2H2AC; HIST1H4C; H3F3B; UHRF1; DNMT1
R-HSA-5693538 Homology Directed Repair 8.22 0.00e+00 0.00e+00 30/73 RPA2; CLSPN; BARD1; POLQ; TOPBP1; RFC4; RFC1; HIST1H4C; RPA3; RFC2; XRCC2; RMI1; FEN1; RAD9A; POLD3; CHEK1; RAD51AP1; CDK2; TIMELESS; RFC5; BRCA2; RFC3; RAD51; BLM; UBE2I; RMI2; UBB; BRCA1; RBBP8; PCNA
R-HSA-5693567 HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) 8.12 0.00e+00 0.00e+00 28/69 RPA2; CLSPN; BARD1; TOPBP1; RFC4; RFC1; HIST1H4C; RPA3; RFC2; XRCC2; RMI1; RAD9A; POLD3; CHEK1; RAD51AP1; CDK2; TIMELESS; RFC5; BRCA2; RFC3; RAD51; BLM; UBE2I; RMI2; UBB; BRCA1; RBBP8; PCNA
R-HSA-5693532 DNA Double-Strand Break Repair 8.05 0.00e+00 0.00e+00 35/87 RPA2; CLSPN; RIF1; BARD1; XRCC5; POLQ; TOPBP1; RFC4; RFC1; HIST1H4C; RPA3; BAZ1B; RFC2; XRCC2; PRKDC; RMI1; FEN1; RAD9A; POLD3; CHEK1; RAD51AP1; CDK2; TIMELESS; RFC5; BRCA2; RFC3; RAD51; BLM; UBE2I; RMI2; UBB; BRCA1; KPNA2; RBBP8; PCNA
R-HSA-2514853 Condensation of Prometaphase Chromosomes 8.00 1.00e-03 7.99e-03 4/10 NCAPG; CCNB1; SMC2; CCNB2
R-HSA-5693607 Processing of DNA double-strand break ends 7.93 1.24e-14 5.25e-13 21/53 RPA2; CLSPN; BARD1; TOPBP1; RFC4; HIST1H4C; RPA3; RFC2; RMI1; RAD9A; CHEK1; CDK2; TIMELESS; RFC5; RFC3; BLM; UBE2I; RMI2; UBB; BRCA1; RBBP8
R-HSA-1538133 G0 and Early G1 7.78 1.39e-05 1.50e-04 7/18 CDK2; TFDP1; CDC6; PCNA; E2F1; MYBL2; CCNE1
R-HSA-1500620 Meiosis 7.73 7.78e-12 2.15e-10 17/44 RPA2; HIST2H2AC; MND1; HIST1H4C; RPA3; SMC1A; SMC3; CDK2; CDK4; BRCA2; SYNE2; RAD51; BLM; UBE2I; BRCA1; H3F3B; RBBP8
R-HSA-2559584 Formation of Senescence-Associated Heterochromatin Foci (SAHF) 7.70 2.74e-04 2.45e-03 5/13 HIST1H1A; HIST1H1C; HIST1H1E; HIST1H1D; HIST1H1B
R-HSA-69473 G2/M DNA damage checkpoint 7.50 3.32e-12 1.05e-10 18/48 RPA2; BARD1; TOPBP1; RFC4; CCNB1; HIST1H4C; RPA3; RFC2; RMI1; RAD9A; CHEK1; RFC5; RFC3; BLM; RMI2; BRCA1; RBBP8; YWHAH
R-HSA-6783310 Fanconi Anemia Pathway 7.37 2.10e-05 2.22e-04 7/19 RPA2; USP1; UBE2T; RPA3; FANCG; UBB; STRA13
R-HSA-2468052 Establishment of Sister Chromatid Cohesion 7.28 1.51e-03 1.14e-02 4/11 SMC1A; ESCO2; CDCA5; SMC3
R-HSA-162594 Early Phase of HIV Life Cycle 7.28 1.51e-03 1.14e-02 4/11 XRCC5; PSIP1; FEN1; LIG1
R-HSA-73886 Chromosome Maintenance 7.25 1.04e-13 3.70e-12 21/58 RPA2; HIST2H2AC; CENPA; RFC4; RFC1; CENPU; CENPK; HIST1H4C; RPA3; RFC2; CENPP; FEN1; POLA2; POLD3; PRIM1; RFC5; RFC3; STRA13; PCNA; LIG1; CENPM
R-HSA-110313 Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template 7.10 1.28e-07 1.77e-06 11/31 RPA2; RFC4; RFC1; RPA3; RFC2; POLD3; RFC5; RFC3; KIAA0101; UBB; PCNA
R-HSA-1474165 Reproduction 7.09 4.03e-11 9.15e-10 17/48 RPA2; HIST2H2AC; MND1; HIST1H4C; RPA3; SMC1A; SMC3; CDK2; CDK4; BRCA2; SYNE2; RAD51; BLM; UBE2I; BRCA1; H3F3B; RBBP8
R-HSA-6804756 Regulation of TP53 Activity through Phosphorylation 6.67 2.54e-12 8.33e-11 20/60 RPA2; BARD1; TOPBP1; RFC4; RPA3; RFC2; RMI1; RAD9A; CHEK1; CDK2; RFC5; RFC3; SUPT16H; BLM; RMI2; UBB; BRCA1; RBBP8; TPX2; AURKA
R-HSA-8864260 Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors 6.67 5.89e-04 4.97e-03 5/15 DEK; ATAD2; YEATS4; UBE2I; MYBL2
R-HSA-2299718 Condensation of Prophase Chromosomes 6.67 4.46e-05 4.54e-04 7/21 HIST2H2AC; CCNB1; HIST1H4C; SMC2; NCAPD3; PLK1; H3F3B
R-HSA-157858 Gap junction trafficking and regulation 6.67 2.18e-03 1.61e-02 4/12 TUBB4B; TUBA1A; TUBA1C; ACTG1
R-HSA-190828 Gap junction trafficking 6.67 2.18e-03 1.61e-02 4/12 TUBB4B; TUBA1A; TUBA1C; ACTG1
R-HSA-69306 DNA Replication 6.61 0.00e+00 0.00e+00 34/103 E2F2; RPA2; MCM6; MCM2; RFC4; RFC1; GMNN; MCM3; RPA3; RFC2; MCM7; GINS4; MCM4; FEN1; POLA2; POLD3; MCM10; CDK2; PRIM1; RFC5; RFC3; ORC6; GINS2; CDT1; UBB; CDC6; PCNA; MCM8; E2F1; UBE2C; CCNE1; LIG1; CDC45; MCM5
R-HSA-73893 DNA Damage Bypass 6.50 2.95e-08 4.43e-07 13/40 RPA2; USP1; DTL; RFC4; RFC1; RPA3; RFC2; POLD3; RFC5; RFC3; KIAA0101; UBB; PCNA
R-HSA-8953750 Transcriptional Regulation by E2F6 6.43 4.86e-06 5.52e-05 9/28 RRM2; EZH2; CHEK1; TFDP1; RAD51; SUZ12; BRCA1; RBBP8; E2F1
R-HSA-5696400 Dual Incision in GG-NER 6.25 1.89e-06 2.29e-05 10/32 RPA2; RFC4; RFC1; RPA3; RFC2; POLD3; RFC5; RFC3; UBB; PCNA
R-HSA-69239 Synthesis of DNA 6.19 0.00e+00 0.00e+00 30/97 RPA2; MCM6; MCM2; RFC4; RFC1; MCM3; RPA3; RFC2; MCM7; GINS4; MCM4; FEN1; POLA2; POLD3; CDK2; PRIM1; RFC5; RFC3; ORC6; GINS2; CDT1; UBB; CDC6; PCNA; MCM8; UBE2C; CCNE1; LIG1; CDC45; MCM5
R-HSA-1362277 Transcription of E2F targets under negative control by DREAM complex 6.16 3.03e-03 2.18e-02 4/13 TFDP1; CDC6; PCNA; E2F1
R-HSA-69481 G2/M Checkpoints 6.02 0.00e+00 0.00e+00 34/113 RPA2; CLSPN; MCM6; BARD1; MCM2; TOPBP1; RFC4; CCNB1; HIST1H4C; MCM3; RPA3; RFC2; MCM7; MCM4; RMI1; RAD9A; CHEK1; MCM10; CDK2; RFC5; RFC3; CCNB2; BLM; PKMYT1; RMI2; ORC6; UBB; CDC6; BRCA1; RBBP8; MCM8; CDC45; YWHAH; MCM5
R-HSA-212300 PRC2 methylates histones and DNA 6.00 3.10e-04 2.69e-03 6/20 HIST2H2AC; HIST1H4C; EZH2; SUZ12; H3F3B; DNMT1
R-HSA-69206 G1/S Transition 5.83 3.33e-16 1.55e-14 30/103 RPA2; RRM2; MCM6; MCM2; CCNB1; DHFR; GMNN; MCM3; FBXO5; RPA3; MCM7; MCM4; POLA2; MCM10; CDK2; PRIM1; CDK4; TFDP1; ORC6; CDT1; UBB; CDC6; TK1; TYMS; PCNA; MCM8; E2F1; CCNE1; CDC45; MCM5
R-HSA-69242 S Phase 5.78 0.00e+00 0.00e+00 37/128 RPA2; MCM6; MCM2; RFC4; RFC1; MCM3; RPA3; RFC2; MCM7; SMC1A; ESCO2; GINS4; MCM4; FEN1; CDCA5; POLA2; POLD3; SMC3; CDK2; PRIM1; CDK4; RFC5; RFC3; TFDP1; ORC6; GINS2; CDT1; UBB; CDC6; PCNA; MCM8; E2F1; UBE2C; CCNE1; LIG1; CDC45; MCM5
R-HSA-69002 DNA Replication Pre-Initiation 5.76 1.75e-11 4.09e-10 21/73 E2F2; RPA2; MCM6; MCM2; GMNN; MCM3; RPA3; MCM7; MCM4; POLA2; MCM10; CDK2; PRIM1; ORC6; CDT1; UBB; CDC6; MCM8; E2F1; CDC45; MCM5
R-HSA-6804114 TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest 5.72 4.07e-03 2.84e-02 4/14 CCNB1; TFDP1; PCNA; AURKA
R-HSA-453279 Mitotic G1-G1/S phases 5.62 1.11e-16 5.46e-15 32/114 E2F2; RPA2; RRM2; MCM6; MCM2; CCNB1; DHFR; GMNN; MCM3; FBXO5; RPA3; MCM7; MCM4; POLA2; MCM10; CDK2; PRIM1; CDK4; TFDP1; ORC6; CDT1; UBB; CDC6; TK1; TYMS; PCNA; MCM8; E2F1; MYBL2; CCNE1; CDC45; MCM5
R-HSA-69273 Cyclin A/B1/B2 associated events during G2/M transition 5.56 1.49e-03 1.14e-02 5/18 CCNB1; CDK2; CCNB2; PKMYT1; PLK1
R-HSA-499943 Interconversion of nucleotide di- and triphosphates 5.56 1.49e-03 1.14e-02 5/18 RRM2; RRM1; DUT; DCTPP1; TYMS
R-HSA-5620924 Intraflagellar transport 5.46 5.48e-04 4.67e-03 6/22 HSPB11; WDR34; TUBB4B; TUBA1A; TUBA1C; DYNLL1
R-HSA-1221632 Meiotic synapsis 5.39 2.04e-04 1.88e-03 7/26 HIST2H2AC; HIST1H4C; SMC1A; SMC3; SYNE2; UBE2I; BRCA1
R-HSA-2559586 DNA Damage/Telomere Stress Induced Senescence 5.30 2.84e-05 2.96e-04 9/34 HIST2H2AC; HIST1H1A; HIST1H1C; HIST1H4C; HIST1H1E; HIST1H1D; HIST1H1B; CDK2; CCNE1
R-HSA-2500257 Resolution of Sister Chromatid Cohesion 5.16 7.55e-12 2.15e-10 24/93 CDC20; NUF2; CENPF; CENPA; BUB1; SPC25; CENPE; CENPU; CENPK; CCNB1; SMC1A; CENPP; TUBB4B; CDCA5; ZWINT; SMC3; TUBA1A; TUBA1C; DYNLL1; CCNB2; PLK1; BIRC5; DSN1; CENPM
R-HSA-5689901 Metalloprotease DUBs 5.00 2.48e-03 1.81e-02 5/20 HIST2H2AC; BARD1; HIST1H2AH; UBB; BRCA1
R-HSA-8848021 Signaling by PTK6 5.00 9.09e-04 7.46e-03 6/24 SFPQ; KRAS; CDK2; CDK4; UBB; CCNE1
R-HSA-9006927 Signaling by Non-Receptor Tyrosine Kinases 5.00 9.09e-04 7.46e-03 6/24 SFPQ; KRAS; CDK2; CDK4; UBB; CCNE1
R-HSA-5626467 RHO GTPases activate IQGAPs 5.00 6.85e-03 4.62e-02 4/16 TUBB4B; TUBA1A; TUBA1C; ACTG1
R-HSA-69620 Cell Cycle Checkpoints 4.98 0.00e+00 0.00e+00 52/209 RPA2; CLSPN; CDC20; NUF2; CENPF; CENPA; BUB1; MCM6; SPC25; BARD1; MCM2; TOPBP1; RFC4; CENPE; CENPU; CENPK; CCNB1; HIST1H4C; MCM3; RPA3; RFC2; MCM7; MCM4; RMI1; CENPP; RAD9A; CHEK1; MCM10; ZWINT; CDK2; RFC5; DYNLL1; RFC3; CCNB2; BLM; PKMYT1; RMI2; PLK1; ORC6; UBB; CDC6; BRCA1; BIRC5; RBBP8; MCM8; DSN1; UBE2C; CCNE1; CDC45; YWHAH; MCM5; CENPM
R-HSA-606279 Deposition of new CENPA-containing nucleosomes at the centromere 4.85 1.58e-04 1.52e-03 8/33 HIST2H2AC; CENPA; CENPU; CENPK; HIST1H4C; CENPP; STRA13; CENPM
R-HSA-774815 Nucleosome assembly 4.85 1.58e-04 1.52e-03 8/33 HIST2H2AC; CENPA; CENPU; CENPK; HIST1H4C; CENPP; STRA13; CENPM
R-HSA-6791312 TP53 Regulates Transcription of Cell Cycle Genes 4.71 1.98e-04 1.85e-03 8/34 CCNB1; E2F8; CDK2; TFDP1; PCNA; E2F1; AURKA; CCNE1
R-HSA-1640170 Cell Cycle 4.65 0.00e+00 0.00e+00 99/426 E2F2; RPA2; CLSPN; CDC20; HIST2H2AC; NUF2; NEK2; CENPF; RRM2; CENPA; BUB1; MCM6; SPC25; BARD1; MCM2; TOPBP1; RFC4; NCAPG; RFC1; CENPE; MND1; CENPU; CENPK; CCNB1; DHFR; PTTG1; HMMR; GMNN; HIST1H4C; MCM3; FBXO5; RPA3; RFC2; MCM7; SMC1A; ESCO2; GINS4; MCM4; CEP78; RMI1; CENPP; SMC2; TUBB4B; FEN1; CDCA5; POLA2; RAD9A; POLD3; CHEK1; NCAPD3; MCM10; MASTL; ZWINT; SMC3; TUBA1A; TUBA1C; CDK2; PRIM1; CDK4; RFC5; DYNLL1; BRCA2; RFC3; TFDP1; SYNE2; RAD51; CEP152; CCNB2; BLM; UBE2I; PKMYT1; RMI2; PLK1; ORC6; GINS2; CDT1; UBB; CDC6; BRCA1; H3F3B; TK1; BIRC5; STRA13; TYMS; RBBP8; PCNA; MCM8; TPX2; E2F1; DSN1; MYBL2; UBE2C; AURKA; CCNE1; LIG1; CDC45; YWHAH; MCM5; CENPM
R-HSA-69278 Cell Cycle, Mitotic 4.58 0.00e+00 0.00e+00 82/358 E2F2; RPA2; CDC20; HIST2H2AC; NUF2; NEK2; CENPF; RRM2; CENPA; BUB1; MCM6; SPC25; MCM2; RFC4; NCAPG; RFC1; CENPE; CENPU; CENPK; CCNB1; DHFR; PTTG1; HMMR; GMNN; HIST1H4C; MCM3; FBXO5; RPA3; RFC2; MCM7; SMC1A; ESCO2; GINS4; MCM4; CEP78; CENPP; SMC2; TUBB4B; FEN1; CDCA5; POLA2; POLD3; NCAPD3; MCM10; MASTL; ZWINT; SMC3; TUBA1A; TUBA1C; CDK2; PRIM1; CDK4; RFC5; DYNLL1; RFC3; TFDP1; CEP152; CCNB2; PKMYT1; PLK1; ORC6; GINS2; CDT1; UBB; CDC6; H3F3B; TK1; BIRC5; TYMS; PCNA; MCM8; TPX2; E2F1; DSN1; MYBL2; UBE2C; AURKA; CCNE1; LIG1; CDC45; MCM5; CENPM
R-HSA-73894 DNA Repair 4.57 0.00e+00 0.00e+00 45/197 RPA2; CLSPN; USP1; UBE2T; DTL; MSH2; MSH6; RIF1; BARD1; XRCC5; POLQ; TOPBP1; RFC4; RFC1; HIST1H4C; RPA3; BAZ1B; RFC2; XRCC2; PRKDC; FANCG; RMI1; FEN1; RAD9A; POLD3; CHEK1; RAD51AP1; CDK2; TIMELESS; UNG; RFC5; BRCA2; RFC3; RAD51; KIAA0101; BLM; UBE2I; RMI2; UBB; BRCA1; KPNA2; STRA13; RBBP8; PCNA; LIG1
R-HSA-68867 Assembly of the pre-replicative complex 4.52 1.31e-06 1.66e-05 14/62 E2F2; MCM6; MCM2; GMNN; MCM3; MCM7; MCM4; ORC6; CDT1; UBB; CDC6; MCM8; E2F1; MCM5
R-HSA-5693606 DNA Double Strand Break Response 4.38 8.07e-04 6.75e-03 7/32 BARD1; HIST1H4C; BAZ1B; UBE2I; UBB; BRCA1; KPNA2
R-HSA-141424 Amplification of signal from the kinetochores 4.27 5.09e-07 6.64e-06 16/75 CDC20; NUF2; CENPF; CENPA; BUB1; SPC25; CENPE; CENPU; CENPK; CENPP; ZWINT; DYNLL1; PLK1; BIRC5; DSN1; CENPM
R-HSA-141444 Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal 4.27 5.09e-07 6.64e-06 16/75 CDC20; NUF2; CENPF; CENPA; BUB1; SPC25; CENPE; CENPU; CENPK; CENPP; ZWINT; DYNLL1; PLK1; BIRC5; DSN1; CENPM
R-HSA-5663220 RHO GTPases Activate Formins 4.26 1.83e-08 2.89e-07 20/94 CDC20; NUF2; CENPF; CENPA; BUB1; SPC25; CENPE; CENPU; CENPK; CENPP; TUBB4B; ZWINT; TUBA1A; TUBA1C; DYNLL1; PLK1; BIRC5; ACTG1; DSN1; CENPM
R-HSA-75153 Apoptotic execution phase 4.24 9.82e-04 7.91e-03 7/33 CLSPN; HMGB2; HIST1H1A; HIST1H1C; HIST1H1E; HIST1H1D; HIST1H1B
R-HSA-5633007 Regulation of TP53 Activity 4.20 1.01e-08 1.68e-07 21/100 RPA2; BARD1; TOPBP1; RFC4; ING2; RPA3; RFC2; RMI1; RAD9A; CHEK1; CDK2; RFC5; RFC3; SUPT16H; BLM; RMI2; UBB; BRCA1; RBBP8; TPX2; AURKA
R-HSA-6782210 Gap-filling DNA repair synthesis and ligation in TC-NER 4.15 4.37e-05 4.50e-04 11/53 RPA2; RFC4; RFC1; RPA3; RFC2; POLD3; RFC5; RFC3; UBB; PCNA; LIG1
R-HSA-5693571 Nonhomologous End-Joining (NHEJ) 4.14 2.60e-03 1.89e-02 6/29 RIF1; BARD1; XRCC5; HIST1H4C; PRKDC; BRCA1
R-HSA-1912408 Pre-NOTCH Transcription and Translation 4.00 6.93e-03 4.62e-02 5/25 HIST2H2AC; HIST1H4C; TFDP1; H3F3B; E2F1
R-HSA-2559585 Oncogene Induced Senescence 4.00 6.93e-03 4.62e-02 5/25 E2F2; CDK4; TFDP1; UBB; E2F1
R-HSA-68877 Mitotic Prometaphase 3.97 4.86e-11 1.05e-09 29/146 CDC20; NUF2; NEK2; CENPF; CENPA; BUB1; SPC25; NCAPG; CENPE; CENPU; CENPK; CCNB1; SMC1A; CEP78; CENPP; SMC2; TUBB4B; CDCA5; ZWINT; SMC3; TUBA1A; TUBA1C; DYNLL1; CEP152; CCNB2; PLK1; BIRC5; DSN1; CENPM
R-HSA-5693565 Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks 3.87 3.71e-03 2.61e-02 6/31 BARD1; HIST1H4C; BAZ1B; UBE2I; UBB; BRCA1
R-HSA-69618 Mitotic Spindle Checkpoint 3.87 9.89e-07 1.27e-05 17/88 CDC20; NUF2; CENPF; CENPA; BUB1; SPC25; CENPE; CENPU; CENPK; CENPP; ZWINT; DYNLL1; PLK1; BIRC5; DSN1; UBE2C; CENPM
R-HSA-68949 Orc1 removal from chromatin 3.81 4.83e-05 4.86e-04 12/63 MCM6; MCM2; MCM3; MCM7; MCM4; CDK2; ORC6; CDT1; UBB; CDC6; MCM8; MCM5
R-HSA-2559580 Oxidative Stress Induced Senescence 3.78 2.27e-04 2.08e-03 10/53 E2F2; HIST2H2AC; HIST1H4C; EZH2; CDK4; TFDP1; UBB; SUZ12; H3F3B; E2F1
R-HSA-6782135 Dual incision in TC-NER 3.71 2.67e-04 2.42e-03 10/54 RPA2; RFC4; RFC1; RPA3; RFC2; POLD3; RFC5; RFC3; UBB; PCNA
R-HSA-8854518 AURKA Activation by TPX2 3.64 3.13e-04 2.69e-03 10/55 NEK2; HMMR; CEP78; TUBB4B; TUBA1A; DYNLL1; CEP152; PLK1; TPX2; AURKA
R-HSA-69052 Switching of origins to a post-replicative state 3.64 1.95e-05 2.08e-04 14/77 MCM6; MCM2; MCM3; MCM7; MCM4; CDK2; ORC6; CDT1; UBB; CDC6; MCM8; UBE2C; CCNE1; MCM5
R-HSA-2559583 Cellular Senescence 3.57 1.62e-06 2.03e-05 18/101 E2F2; HIST2H2AC; HIST1H1A; HIST1H1C; HIST1H4C; HIST1H1E; HIST1H1D; HIST1H1B; EZH2; CDK2; CDK4; TFDP1; UBB; SUZ12; H3F3B; E2F1; UBE2C; CCNE1
R-HSA-5696399 Global Genome Nucleotide Excision Repair (GG-NER) 3.53 1.06e-04 1.04e-03 12/68 RPA2; RFC4; RFC1; RPA3; RFC2; POLD3; RFC5; RFC3; UBE2I; UBB; PCNA; LIG1
R-HSA-6781827 Transcription-Coupled Nucleotide Excision Repair (TC-NER) 3.39 3.03e-04 2.66e-03 11/65 RPA2; RFC4; RFC1; RPA3; RFC2; POLD3; RFC5; RFC3; UBB; PCNA; LIG1
R-HSA-2565942 Regulation of PLK1 Activity at G2/M Transition 3.39 3.03e-04 2.66e-03 11/65 NEK2; CCNB1; CEP78; TUBB4B; TUBA1A; DYNLL1; CEP152; CCNB2; PLK1; UBB; AURKA
R-HSA-2467813 Separation of Sister Chromatids 3.34 5.23e-08 7.57e-07 25/150 CDC20; NUF2; CENPF; CENPA; BUB1; SPC25; CENPE; CENPU; CENPK; PTTG1; SMC1A; CENPP; TUBB4B; CDCA5; ZWINT; SMC3; TUBA1A; TUBA1C; DYNLL1; PLK1; UBB; BIRC5; DSN1; UBE2C; CENPM
R-HSA-2555396 Mitotic Metaphase and Anaphase 3.27 4.13e-08 6.10e-07 26/159 CDC20; NUF2; CENPF; CENPA; BUB1; SPC25; CENPE; CENPU; CENPK; PTTG1; FBXO5; SMC1A; CENPP; TUBB4B; CDCA5; ZWINT; SMC3; TUBA1A; TUBA1C; DYNLL1; PLK1; UBB; BIRC5; DSN1; UBE2C; CENPM
R-HSA-195258 RHO GTPase Effectors 3.25 2.47e-08 3.85e-07 27/166 CDC20; HIST2H2AC; NUF2; KIF14; CENPF; CENPA; BUB1; SPC25; CENPE; CENPU; CENPK; HIST1H4C; CENPP; TUBB4B; ZWINT; TUBA1A; TUBA1C; DYNLL1; PLK1; H3F3B; BIRC5; ACTG1; MYL12A; DSN1; YWHAH; RAC2; CENPM
R-HSA-68882 Mitotic Anaphase 3.17 1.51e-07 2.06e-06 25/158 CDC20; NUF2; CENPF; CENPA; BUB1; SPC25; CENPE; CENPU; CENPK; PTTG1; SMC1A; CENPP; TUBB4B; CDCA5; ZWINT; SMC3; TUBA1A; TUBA1C; DYNLL1; PLK1; UBB; BIRC5; DSN1; UBE2C; CENPM
R-HSA-2559582 Senescence-Associated Secretory Phenotype (SASP) 3.11 6.28e-03 4.28e-02 7/45 HIST2H2AC; HIST1H4C; CDK2; CDK4; UBB; H3F3B; UBE2C
R-HSA-15869 Metabolism of nucleotides 2.91 5.40e-03 3.74e-02 8/55 RRM2; GMPS; PAICS; RRM1; DUT; DCTPP1; TK1; TYMS
R-HSA-68886 M Phase 2.89 7.86e-10 1.58e-08 38/263 CDC20; HIST2H2AC; NUF2; NEK2; CENPF; CENPA; BUB1; SPC25; NCAPG; CENPE; CENPU; CENPK; CCNB1; PTTG1; HIST1H4C; FBXO5; SMC1A; CEP78; CENPP; SMC2; TUBB4B; CDCA5; NCAPD3; MASTL; ZWINT; SMC3; TUBA1A; TUBA1C; DYNLL1; CEP152; CCNB2; PLK1; UBB; H3F3B; BIRC5; DSN1; UBE2C; CENPM
R-HSA-68875 Mitotic Prophase 2.69 5.54e-03 3.81e-02 9/67 HIST2H2AC; CCNB1; HIST1H4C; SMC2; NCAPD3; MASTL; CCNB2; PLK1; H3F3B
R-HSA-5696398 Nucleotide Excision Repair 2.67 1.51e-03 1.14e-02 12/90 RPA2; RFC4; RFC1; RPA3; RFC2; POLD3; RFC5; RFC3; UBE2I; UBB; PCNA; LIG1
R-HSA-174143 APC/C-mediated degradation of cell cycle proteins 2.67 3.71e-03 2.61e-02 10/75 CDC20; NEK2; CCNB1; PTTG1; FBXO5; CDK2; PLK1; UBB; UBE2C; AURKA
R-HSA-453276 Regulation of mitotic cell cycle 2.67 3.71e-03 2.61e-02 10/75 CDC20; NEK2; CCNB1; PTTG1; FBXO5; CDK2; PLK1; UBB; UBE2C; AURKA
R-HSA-453274 Mitotic G2-G2/M phases 2.66 6.81e-05 6.77e-04 19/143 NEK2; CENPF; CCNB1; HMMR; CEP78; TUBB4B; TUBA1A; TUBA1C; CDK2; DYNLL1; CEP152; CCNB2; PKMYT1; PLK1; UBB; TPX2; E2F1; MYBL2; AURKA
R-HSA-194315 Signaling by Rho GTPases 2.61 2.53e-06 2.94e-05 27/207 CDC20; HIST2H2AC; NUF2; KIF14; CENPF; CENPA; BUB1; SPC25; CENPE; CENPU; CENPK; HIST1H4C; CENPP; TUBB4B; ZWINT; TUBA1A; TUBA1C; DYNLL1; PLK1; H3F3B; BIRC5; ACTG1; MYL12A; DSN1; YWHAH; RAC2; CENPM
R-HSA-69275 G2/M Transition 2.55 1.80e-04 1.70e-03 18/141 NEK2; CENPF; CCNB1; HMMR; CEP78; TUBB4B; TUBA1A; TUBA1C; CDK2; DYNLL1; CEP152; CCNB2; PKMYT1; PLK1; UBB; TPX2; MYBL2; AURKA
R-HSA-3108232 SUMO E3 ligases SUMOylate target proteins 2.52 1.08e-03 8.56e-03 14/111 SMC6; ING2; HIST1H4C; CASP8AP2; SMC1A; SMC3; BLM; UBE2I; SUZ12; BRCA1; BIRC5; PCNA; AURKA; DNMT1
R-HSA-3700989 Transcriptional Regulation by TP53 2.45 2.54e-06 2.94e-05 30/245 RPA2; MSH2; BARD1; TOPBP1; RFC4; ING2; CCNB1; RPA3; RFC2; RMI1; E2F8; RAD9A; CHEK1; CDK2; RFC5; RFC3; TFDP1; SUPT16H; BLM; RMI2; UBB; BRCA1; BIRC5; RBBP8; PCNA; TPX2; E2F1; AURKA; CCNE1; YWHAH
R-HSA-2990846 SUMOylation 2.44 1.54e-03 1.15e-02 14/115 SMC6; ING2; HIST1H4C; CASP8AP2; SMC1A; SMC3; BLM; UBE2I; SUZ12; BRCA1; BIRC5; PCNA; AURKA; DNMT1
Factor 7 : 12 significant Reactome pathways
GeneSet description enrichRatio pValue FDR GeneRatio geneSymbols
R-HSA-5669034 TNFs bind their physiological receptors 9.55 7.60e-05 6.12e-03 5/10 TNFRSF18; TNFRSF4; TNFRSF9; CD70; TNFSF14
R-HSA-6783783 Interleukin-10 signaling 7.64 6.43e-05 5.69e-03 6/15 CSF2; CCL3; CCL4; CCL3L3; CCL4L2
R-HSA-373076 Class A/1 (Rhodopsin-like receptors) 5.66 4.60e-05 4.53e-03 8/27 XCL2; XCL1; PTGER4; HRH2; CXCR3; CCL1; S1PR4; PTGIR
R-HSA-500792 GPCR ligand binding 5.16 1.24e-05 2.20e-03 10/37 XCL2; XCL1; RAMP1; PTGER4; HRH2; CXCR3; CCL1; S1PR4; ADGRE5; PTGIR
R-HSA-202733 Cell surface interactions at the vascular wall 4.55 4.16e-05 4.53e-03 10/42 LCK; CD58; CD2; FCER1G; SELL; GYPC; ITGA4; FYN; CD44; SELPLG
R-HSA-198933 Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell 4.02 6.15e-04 4.54e-02 8/38 SELL; CD8B; ITGA4; CD3G; CRTAM; KLRB1; KLRD1; LAIR2
R-HSA-418594 G alpha (i) signalling events 3.65 3.66e-05 4.53e-03 13/68 DHRS3; RGS1; ITPR1; CAMK4; CXCR3; RDH10; RGS10; CCL1; CCL4; CCL4L2; S1PR4; CALM3
R-HSA-372790 Signaling by GPCR 3.06 2.82e-06 8.33e-04 21/131 DHRS3; XCL2; XCL1; RGS1; RAMP1; ITPR1; PTGER4; CAMK4; HRH2; CXCR3; RDH10; RASGRP2; RGS10; CCL1; CCL4; CCL4L2; S1PR4; ADGRE5; CALM3; PTGIR
R-HSA-388396 GPCR downstream signalling 2.96 8.37e-06 1.85e-03 20/129 DHRS3; XCL2; XCL1; RGS1; RAMP1; ITPR1; PTGER4; CAMK4; HRH2; CXCR3; RDH10; RASGRP2; RGS10; CCL1; CCL4; CCL4L2; S1PR4; CALM3; PTGIR
R-HSA-449147 Signaling by Interleukins 2.55 1.65e-06 7.30e-04 29/217 LCK; JUN; PTPN7; IL7R; CSF2; PSMB8; FYN; IL2RG; DUSP4; IL2RA; GATA3; MAP3K8; NFKB2; IFNG; HMGB1; PSME1; NFKBIA; BATF; SOCS1; MAP2K3; CCL3; CCL4; CCL3L3; CCL4L2; BCL2L1; CNN2; JUNB; SOD1
R-HSA-1280215 Cytokine Signaling in Immune system 2.46 1.44e-08 1.27e-05 42/326 TNFRSF18; TNFRSF4; TNFRSF9; LCK; JUN; PTPN7; IL7R; CSF2; LTB; HLA-DQA1; PSMB8; HLA-DPA1; FYN; IL2RG; DUSP4; CD44; BIRC3; IL2RA; GATA3; MAP3K8; NFKB2; IFNG; HMGB1; PSME1; NFKBIA; BATF; ISG20; SOCS1; MT2A; MAP2K3; CCL3; CCL4; CCL3L3; CCL4L2; BCL2L1; SAMHD1; CNN2; CD70; TNFSF14; JUNB; SOD1
R-HSA-109582 Hemostasis 2.32 3.45e-05 4.53e-03 26/214 CAPZB; LCK; CD58; CD2; S100A10; FCER1G; SELL; H3F3A; GYPC; ITGA4; ITPR1; FYN; FAM3C; CD44; RASGRP2; CTSW; GATA3; SRGN; CD9; SELPLG; PPP2R5C; H3F3B; KIF3B; CALM3; PTGIR; SOD1
Factor 8 : 76 significant Reactome pathways
GeneSet description enrichRatio pValue FDR GeneRatio geneSymbols
R-HSA-156842 Eukaryotic Translation Elongation 13.50 0.00e+00 0.00e+00 82/87 RPL22; RPL11; RPS8; RPL5; RPS27; RPS7; RPS27A; RPL31; EEF1B2; RPL37A; RPL32; RPL15; RPSA; RPL14; RPL29; RPL24; RPL22L1; RPL35A; RPL9; RPL34; RPS3A; RPL37; RPS23; RPS14; RPS18; RPS10; RPL10A; EEF1A1; RPS12; RPS4X; RPL36A; RPL39; RPL10; RPS20; RPL7; RPL30; EEF1D; RPL8; RPS6; RPL35; RPL12; RPL7A; RPLP2; RPL27A; RPS13; RPS3; RPS25; RPS24; RPL41; RPL6; RPLP0; RPL21; RPS29; RPL4; RPLP1; RPS17; RPS2; RPS15A; RPL13; RPL26; RPL23A; RPL23; RPL19; RPL27; RPL38; RPL17; RPS21; RPS15; EEF2; RPL36; RPS28; RPL18A; UBA52; RPS16; RPS19; RPL18; RPL13A; RPS11; RPS9; RPL28; RPS5; RPL3
R-HSA-156902 Peptide chain elongation 13.40 0.00e+00 0.00e+00 80/85 RPL22; RPL11; RPS8; RPL5; RPS27; RPS7; RPS27A; RPL31; RPL37A; RPL32; RPL15; RPSA; RPL14; RPL29; RPL24; RPL22L1; RPL35A; RPL9; RPL34; RPS3A; RPL37; RPS23; RPS14; RPS18; RPS10; RPL10A; EEF1A1; RPS12; RPS4X; RPL36A; RPL39; RPL10; RPS20; RPL7; RPL30; RPL8; RPS6; RPL35; RPL12; RPL7A; RPLP2; RPL27A; RPS13; RPS3; RPS25; RPS24; RPL41; RPL6; RPLP0; RPL21; RPS29; RPL4; RPLP1; RPS17; RPS2; RPS15A; RPL13; RPL26; RPL23A; RPL23; RPL19; RPL27; RPL38; RPL17; RPS21; RPS15; EEF2; RPL36; RPS28; RPL18A; UBA52; RPS16; RPS19; RPL18; RPL13A; RPS11; RPS9; RPL28; RPS5; RPL3
R-HSA-192823 Viral mRNA Translation 13.10 0.00e+00 0.00e+00 78/85 RPL22; RPL11; RPS8; RPL5; RPS27; RPS7; RPS27A; RPL31; RPL37A; RPL32; RPL15; RPSA; RPL14; RPL29; RPL24; RPL22L1; RPL35A; RPL9; RPL34; RPS3A; RPL37; RPS23; RPS14; RPS18; RPS10; RPL10A; RPS12; RPS4X; RPL36A; RPL39; RPL10; RPS20; RPL7; RPL30; RPL8; RPS6; RPL35; RPL12; RPL7A; RPLP2; RPL27A; RPS13; RPS3; RPS25; RPS24; RPL41; RPL6; RPLP0; RPL21; RPS29; RPL4; RPLP1; RPS17; RPS2; RPS15A; RPL13; RPL26; RPL23A; RPL23; RPL19; RPL27; RPL38; RPL17; RPS21; RPS15; RPL36; RPS28; RPL18A; UBA52; RPS16; RPS19; RPL18; RPL13A; RPS11; RPS9; RPL28; RPS5; RPL3
R-HSA-2408557 Selenocysteine synthesis 13.10 0.00e+00 0.00e+00 78/85 RPL22; RPL11; RPS8; RPL5; RPS27; RPS7; RPS27A; RPL31; RPL37A; RPL32; RPL15; RPSA; RPL14; RPL29; RPL24; RPL22L1; RPL35A; RPL9; RPL34; RPS3A; RPL37; RPS23; RPS14; RPS18; RPS10; RPL10A; RPS12; RPS4X; RPL36A; RPL39; RPL10; RPS20; RPL7; RPL30; RPL8; RPS6; RPL35; RPL12; RPL7A; RPLP2; RPL27A; RPS13; RPS3; RPS25; RPS24; RPL41; RPL6; RPLP0; RPL21; RPS29; RPL4; RPLP1; RPS17; RPS2; RPS15A; RPL13; RPL26; RPL23A; RPL23; RPL19; RPL27; RPL38; RPL17; RPS21; RPS15; RPL36; RPS28; RPL18A; UBA52; RPS16; RPS19; RPL18; RPL13A; RPS11; RPS9; RPL28; RPS5; RPL3
R-HSA-975956 Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) 12.70 0.00e+00 0.00e+00 79/89 RPL22; RPL11; RPS8; RPL5; RPS27; RPS7; RPS27A; RPL31; RPL37A; RPL32; RPL15; RPSA; RPL14; RPL29; RPL24; RPL22L1; RPL35A; RPL9; RPL34; RPS3A; RPL37; RPS23; RPS14; RPS18; RPS10; RPL10A; RPS12; RPS4X; RPL36A; RPL39; RPL10; RPS20; RPL7; RPL30; PABPC1; RPL8; RPS6; RPL35; RPL12; RPL7A; RPLP2; RPL27A; RPS13; RPS3; RPS25; RPS24; RPL41; RPL6; RPLP0; RPL21; RPS29; RPL4; RPLP1; RPS17; RPS2; RPS15A; RPL13; RPL26; RPL23A; RPL23; RPL19; RPL27; RPL38; RPL17; RPS21; RPS15; RPL36; RPS28; RPL18A; UBA52; RPS16; RPS19; RPL18; RPL13A; RPS11; RPS9; RPL28; RPS5; RPL3
R-HSA-72764 Eukaryotic Translation Termination 12.60 0.00e+00 0.00e+00 78/88 RPL22; RPL11; RPS8; RPL5; RPS27; RPS7; RPS27A; RPL31; RPL37A; RPL32; RPL15; RPSA; RPL14; RPL29; RPL24; RPL22L1; RPL35A; RPL9; RPL34; RPS3A; RPL37; RPS23; RPS14; RPS18; RPS10; RPL10A; RPS12; RPS4X; RPL36A; RPL39; RPL10; RPS20; RPL7; RPL30; RPL8; RPS6; RPL35; RPL12; RPL7A; RPLP2; RPL27A; RPS13; RPS3; RPS25; RPS24; RPL41; RPL6; RPLP0; RPL21; RPS29; RPL4; RPLP1; RPS17; RPS2; RPS15A; RPL13; RPL26; RPL23A; RPL23; RPL19; RPL27; RPL38; RPL17; RPS21; RPS15; RPL36; RPS28; RPL18A; UBA52; RPS16; RPS19; RPL18; RPL13A; RPS11; RPS9; RPL28; RPS5; RPL3
R-HSA-72689 Formation of a pool of free 40S subunits 11.90 0.00e+00 0.00e+00 80/96 RPL22; RPL11; RPS8; RPL5; RPS27; RPS7; RPS27A; RPL31; RPL37A; RPL32; RPL15; RPSA; RPL14; RPL29; RPL24; RPL22L1; RPL35A; RPL9; RPL34; RPS3A; RPL37; RPS23; RPS14; RPS18; RPS10; RPL10A; RPS12; RPS4X; RPL36A; RPL39; RPL10; RPS20; RPL7; RPL30; EIF3E; RPL8; RPS6; RPL35; RPL12; RPL7A; RPLP2; RPL27A; RPS13; EIF3M; RPS3; RPS25; RPS24; RPL41; RPL6; RPLP0; RPL21; RPS29; RPL4; RPLP1; RPS17; RPS2; RPS15A; RPL13; RPL26; RPL23A; RPL23; RPL19; RPL27; RPL38; RPL17; RPS21; RPS15; RPL36; RPS28; RPL18A; UBA52; RPS16; RPS19; RPL18; RPL13A; RPS11; RPS9; RPL28; RPS5; RPL3
R-HSA-2408522 Selenoamino acid metabolism 11.20 0.00e+00 0.00e+00 78/99 RPL22; RPL11; RPS8; RPL5; RPS27; RPS7; RPS27A; RPL31; RPL37A; RPL32; RPL15; RPSA; RPL14; RPL29; RPL24; RPL22L1; RPL35A; RPL9; RPL34; RPS3A; RPL37; RPS23; RPS14; RPS18; RPS10; RPL10A; RPS12; RPS4X; RPL36A; RPL39; RPL10; RPS20; RPL7; RPL30; RPL8; RPS6; RPL35; RPL12; RPL7A; RPLP2; RPL27A; RPS13; RPS3; RPS25; RPS24; RPL41; RPL6; RPLP0; RPL21; RPS29; RPL4; RPLP1; RPS17; RPS2; RPS15A; RPL13; RPL26; RPL23A; RPL23; RPL19; RPL27; RPL38; RPL17; RPS21; RPS15; RPL36; RPS28; RPL18A; UBA52; RPS16; RPS19; RPL18; RPL13A; RPS11; RPS9; RPL28; RPS5; RPL3
R-HSA-156827 L13a-mediated translational silencing of Ceruloplasmin expression 10.90 0.00e+00 0.00e+00 81/106 RPL22; RPL11; RPS8; RPL5; RPS27; RPS7; RPS27A; RPL31; RPL37A; RPL32; RPL15; RPSA; RPL14; RPL29; RPL24; RPL22L1; RPL35A; RPL9; RPL34; RPS3A; RPL37; RPS23; RPS14; RPS18; RPS10; RPL10A; RPS12; RPS4X; RPL36A; RPL39; RPL10; RPS20; RPL7; RPL30; PABPC1; EIF3E; RPL8; RPS6; RPL35; RPL12; RPL7A; RPLP2; RPL27A; RPS13; EIF3M; RPS3; RPS25; RPS24; RPL41; RPL6; RPLP0; RPL21; RPS29; RPL4; RPLP1; RPS17; RPS2; RPS15A; RPL13; RPL26; RPL23A; RPL23; RPL19; RPL27; RPL38; RPL17; RPS21; RPS15; RPL36; RPS28; RPL18A; UBA52; RPS16; RPS19; RPL18; RPL13A; RPS11; RPS9; RPL28; RPS5; RPL3
R-HSA-72706 GTP hydrolysis and joining of the 60S ribosomal subunit 10.70 0.00e+00 0.00e+00 80/107 RPL22; RPL11; RPS8; RPL5; RPS27; RPS7; RPS27A; RPL31; RPL37A; RPL32; RPL15; RPSA; RPL14; RPL29; RPL24; RPL22L1; RPL35A; RPL9; RPL34; RPS3A; RPL37; RPS23; RPS14; RPS18; RPS10; RPL10A; RPS12; RPS4X; RPL36A; RPL39; RPL10; RPS20; RPL7; RPL30; EIF3E; RPL8; RPS6; RPL35; RPL12; RPL7A; RPLP2; RPL27A; RPS13; EIF3M; RPS3; RPS25; RPS24; RPL41; RPL6; RPLP0; RPL21; RPS29; RPL4; RPLP1; RPS17; RPS2; RPS15A; RPL13; RPL26; RPL23A; RPL23; RPL19; RPL27; RPL38; RPL17; RPS21; RPS15; RPL36; RPS28; RPL18A; UBA52; RPS16; RPS19; RPL18; RPL13A; RPS11; RPS9; RPL28; RPS5; RPL3
R-HSA-1799339 SRP-dependent cotranslational protein targeting to membrane 10.70 0.00e+00 0.00e+00 80/107 RPL22; RPL11; RPS8; RPL5; RPS27; RPS7; RPS27A; RPL31; RPL37A; RPL32; RPL15; RPSA; RPL14; RPL29; RPL24; RPL22L1; RPL35A; RPL9; RPL34; RPS3A; RPL37; RPS23; RPS14; RPS18; RPS10; RPL10A; RPS12; RPS4X; RPL36A; RPL39; RPL10; RPS20; RPL7; RPL30; RPL8; RPS6; SEC61B; RPL35; RPL12; RPL7A; RPLP2; RPL27A; RPS13; RPS3; RPS25; RPS24; RPL41; RPL6; RPLP0; RPL21; RPS29; SRP14; RPL4; RPLP1; RPS17; RPS2; RPS15A; RPL13; RPL26; RPL23A; RPL23; RPL19; RPL27; RPL38; RPL17; RPS21; RPS15; RPL36; RPS28; RPL18A; UBA52; RPS16; RPS19; RPL18; RPL13A; RPS11; RPS9; RPL28; RPS5; RPL3
R-HSA-927802 Nonsense-Mediated Decay (NMD) 10.60 0.00e+00 0.00e+00 79/106 RPL22; RPL11; RPS8; RPL5; RPS27; RPS7; RPS27A; RPL31; RPL37A; RPL32; RPL15; RPSA; RPL14; RPL29; RPL24; RPL22L1; RPL35A; RPL9; RPL34; RPS3A; RPL37; RPS23; RPS14; RPS18; RPS10; RPL10A; RPS12; RPS4X; RPL36A; RPL39; RPL10; RPS20; RPL7; RPL30; PABPC1; RPL8; RPS6; RPL35; RPL12; RPL7A; RPLP2; RPL27A; RPS13; RPS3; RPS25; RPS24; RPL41; RPL6; RPLP0; RPL21; RPS29; RPL4; RPLP1; RPS17; RPS2; RPS15A; RPL13; RPL26; RPL23A; RPL23; RPL19; RPL27; RPL38; RPL17; RPS21; RPS15; RPL36; RPS28; RPL18A; UBA52; RPS16; RPS19; RPL18; RPL13A; RPS11; RPS9; RPL28; RPS5; RPL3
R-HSA-975957 Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) 10.60 0.00e+00 0.00e+00 79/106 RPL22; RPL11; RPS8; RPL5; RPS27; RPS7; RPS27A; RPL31; RPL37A; RPL32; RPL15; RPSA; RPL14; RPL29; RPL24; RPL22L1; RPL35A; RPL9; RPL34; RPS3A; RPL37; RPS23; RPS14; RPS18; RPS10; RPL10A; RPS12; RPS4X; RPL36A; RPL39; RPL10; RPS20; RPL7; RPL30; PABPC1; RPL8; RPS6; RPL35; RPL12; RPL7A; RPLP2; RPL27A; RPS13; RPS3; RPS25; RPS24; RPL41; RPL6; RPLP0; RPL21; RPS29; RPL4; RPLP1; RPS17; RPS2; RPS15A; RPL13; RPL26; RPL23A; RPL23; RPL19; RPL27; RPL38; RPL17; RPS21; RPS15; RPL36; RPS28; RPL18A; UBA52; RPS16; RPS19; RPL18; RPL13A; RPS11; RPS9; RPL28; RPS5; RPL3
R-HSA-72613 Eukaryotic Translation Initiation 10.10 0.00e+00 0.00e+00 81/114 RPL22; RPL11; RPS8; RPL5; RPS27; RPS7; RPS27A; RPL31; RPL37A; RPL32; RPL15; RPSA; RPL14; RPL29; RPL24; RPL22L1; RPL35A; RPL9; RPL34; RPS3A; RPL37; RPS23; RPS14; RPS18; RPS10; RPL10A; RPS12; RPS4X; RPL36A; RPL39; RPL10; RPS20; RPL7; RPL30; PABPC1; EIF3E; RPL8; RPS6; RPL35; RPL12; RPL7A; RPLP2; RPL27A; RPS13; EIF3M; RPS3; RPS25; RPS24; RPL41; RPL6; RPLP0; RPL21; RPS29; RPL4; RPLP1; RPS17; RPS2; RPS15A; RPL13; RPL26; RPL23A; RPL23; RPL19; RPL27; RPL38; RPL17; RPS21; RPS15; RPL36; RPS28; RPL18A; UBA52; RPS16; RPS19; RPL18; RPL13A; RPS11; RPS9; RPL28; RPS5; RPL3
R-HSA-72737 Cap-dependent Translation Initiation 10.10 0.00e+00 0.00e+00 81/114 RPL22; RPL11; RPS8; RPL5; RPS27; RPS7; RPS27A; RPL31; RPL37A; RPL32; RPL15; RPSA; RPL14; RPL29; RPL24; RPL22L1; RPL35A; RPL9; RPL34; RPS3A; RPL37; RPS23; RPS14; RPS18; RPS10; RPL10A; RPS12; RPS4X; RPL36A; RPL39; RPL10; RPS20; RPL7; RPL30; PABPC1; EIF3E; RPL8; RPS6; RPL35; RPL12; RPL7A; RPLP2; RPL27A; RPS13; EIF3M; RPS3; RPS25; RPS24; RPL41; RPL6; RPLP0; RPL21; RPS29; RPL4; RPLP1; RPS17; RPS2; RPS15A; RPL13; RPL26; RPL23A; RPL23; RPL19; RPL27; RPL38; RPL17; RPS21; RPS15; RPL36; RPS28; RPL18A; UBA52; RPS16; RPS19; RPL18; RPL13A; RPS11; RPS9; RPL28; RPS5; RPL3
R-HSA-72695 Formation of the ternary complex, and subsequently, the 43S complex 9.51 0.00e+00 0.00e+00 32/48 RPS8; RPS27; RPS7; RPS27A; RPSA; RPS3A; RPS23; RPS14; RPS18; RPS10; RPS12; RPS4X; RPS20; EIF3E; RPS6; RPS13; EIF3M; RPS3; RPS25; RPS24; RPS29; RPS17; RPS2; RPS15A; RPS21; RPS15; RPS28; RPS16; RPS19; RPS11; RPS9; RPS5
R-HSA-389948 PD-1 signaling 9.51 5.32e-09 1.43e-07 10/15 LCK; HLA-DRA; HLA-DRB5; HLA-DRB1; HLA-DQA1; HLA-DQB1; HLA-DPA1; HLA-DPB1; CD3D; PTPN6
R-HSA-168273 Influenza Viral RNA Transcription and Replication 9.32 0.00e+00 0.00e+00 79/121 RPL22; RPL11; RPS8; RPL5; RPS27; RPS7; RPS27A; RPL31; RPL37A; RPL32; RPL15; RPSA; RPL14; RPL29; RPL24; RPL22L1; RPL35A; RPL9; RPL34; RPS3A; RPL37; RPS23; RPS14; RPS18; RPS10; RPL10A; RPS12; RPS4X; RPL36A; RPL39; RPL10; RPS20; RPL7; RPL30; RPL8; RPS6; RPL35; RPL12; RPL7A; RPLP2; POLR2L; RPL27A; RPS13; RPS3; RPS25; RPS24; RPL41; RPL6; RPLP0; RPL21; RPS29; RPL4; RPLP1; RPS17; RPS2; RPS15A; RPL13; RPL26; RPL23A; RPL23; RPL19; RPL27; RPL38; RPL17; RPS21; RPS15; RPL36; RPS28; RPL18A; UBA52; RPS16; RPS19; RPL18; RPL13A; RPS11; RPS9; RPL28; RPS5; RPL3
R-HSA-202430 Translocation of ZAP-70 to Immunological synapse 9.17 5.24e-08 1.36e-06 9/14 LCK; HLA-DRA; HLA-DRB5; HLA-DRB1; HLA-DQA1; HLA-DQB1; HLA-DPA1; HLA-DPB1; CD3D
R-HSA-168255 Influenza Life Cycle 8.67 0.00e+00 0.00e+00 79/130 RPL22; RPL11; RPS8; RPL5; RPS27; RPS7; RPS27A; RPL31; RPL37A; RPL32; RPL15; RPSA; RPL14; RPL29; RPL24; RPL22L1; RPL35A; RPL9; RPL34; RPS3A; RPL37; RPS23; RPS14; RPS18; RPS10; RPL10A; RPS12; RPS4X; RPL36A; RPL39; RPL10; RPS20; RPL7; RPL30; RPL8; RPS6; RPL35; RPL12; RPL7A; RPLP2; POLR2L; RPL27A; RPS13; RPS3; RPS25; RPS24; RPL41; RPL6; RPLP0; RPL21; RPS29; RPL4; RPLP1; RPS17; RPS2; RPS15A; RPL13; RPL26; RPL23A; RPL23; RPL19; RPL27; RPL38; RPL17; RPS21; RPS15; RPL36; RPS28; RPL18A; UBA52; RPS16; RPS19; RPL18; RPL13A; RPS11; RPS9; RPL28; RPS5; RPL3
R-HSA-72649 Translation initiation complex formation 8.56 0.00e+00 0.00e+00 33/55 RPS8; RPS27; RPS7; RPS27A; RPSA; RPS3A; RPS23; RPS14; RPS18; RPS10; RPS12; RPS4X; RPS20; PABPC1; EIF3E; RPS6; RPS13; EIF3M; RPS3; RPS25; RPS24; RPS29; RPS17; RPS2; RPS15A; RPS21; RPS15; RPS28; RPS16; RPS19; RPS11; RPS9; RPS5
R-HSA-72662 Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S 8.41 0.00e+00 0.00e+00 33/56 RPS8; RPS27; RPS7; RPS27A; RPSA; RPS3A; RPS23; RPS14; RPS18; RPS10; RPS12; RPS4X; RPS20; PABPC1; EIF3E; RPS6; RPS13; EIF3M; RPS3; RPS25; RPS24; RPS29; RPS17; RPS2; RPS15A; RPS21; RPS15; RPS28; RPS16; RPS19; RPS11; RPS9; RPS5
R-HSA-9010553 Regulation of expression of SLITs and ROBOs 8.35 0.00e+00 0.00e+00 86/147 RPL22; RPL11; RPS8; RPL5; RPS27; RPS7; RPS27A; RPL31; RPL37A; RPL32; RPL15; RPSA; RPL14; RPL29; RPL24; RPL22L1; RPL35A; RPL9; RPL34; RPS3A; RPL37; RPS23; RPS14; PSMB8; PSMB9; RPS18; RPS10; RPL10A; RPS12; RPS4X; RPL36A; RPL39; RPL10; RPS20; RPL7; RPL30; PABPC1; RPL8; RPS6; RPL35; RPL12; RPL7A; RPLP2; RPL27A; RPS13; RPS3; RPS25; RPS24; RPL41; RPL6; RPLP0; RPL21; PSME2; RPS29; RPL4; RPLP1; RPS17; RPS2; TCEB2; RPS15A; RPL13; PSMB6; RPL26; RPL23A; PSMB3; RPL23; RPL19; RPL27; RPL38; RPL17; PSMA7; RPS21; RPS15; RPL36; RPS28; RPL18A; UBA52; RPS16; RPS19; RPL18; RPL13A; RPS11; RPS9; RPL28; RPS5; RPL3
R-HSA-72702 Ribosomal scanning and start codon recognition 8.30 0.00e+00 0.00e+00 32/55 RPS8; RPS27; RPS7; RPS27A; RPSA; RPS3A; RPS23; RPS14; RPS18; RPS10; RPS12; RPS4X; RPS20; EIF3E; RPS6; RPS13; EIF3M; RPS3; RPS25; RPS24; RPS29; RPS17; RPS2; RPS15A; RPS21; RPS15; RPS28; RPS16; RPS19; RPS11; RPS9; RPS5
R-HSA-168254 Influenza Infection 8.21 0.00e+00 0.00e+00 80/139 RPL22; RPL11; RPS8; RPL5; RPS27; RPS7; RPS27A; RPL31; RPL37A; RPL32; RPL15; RPSA; RPL14; RPL29; RPL24; RPL22L1; RPL35A; RPL9; RPL34; RPS3A; RPL37; RPS23; RPS14; RPS18; RPS10; RPL10A; RPS12; SLC25A6; RPS4X; RPL36A; RPL39; RPL10; RPS20; RPL7; RPL30; RPL8; RPS6; RPL35; RPL12; RPL7A; RPLP2; POLR2L; RPL27A; RPS13; RPS3; RPS25; RPS24; RPL41; RPL6; RPLP0; RPL21; RPS29; RPL4; RPLP1; RPS17; RPS2; RPS15A; RPL13; RPL26; RPL23A; RPL23; RPL19; RPL27; RPL38; RPL17; RPS21; RPS15; RPL36; RPS28; RPL18A; UBA52; RPS16; RPS19; RPL18; RPL13A; RPS11; RPS9; RPL28; RPS5; RPL3
R-HSA-202427 Phosphorylation of CD3 and TCR zeta chains 8.03 2.64e-07 6.32e-06 9/16 LCK; HLA-DRA; HLA-DRB5; HLA-DRB1; HLA-DQA1; HLA-DQB1; HLA-DPA1; HLA-DPB1; CD3D
R-HSA-376176 Signaling by ROBO receptors 7.61 0.00e+00 0.00e+00 89/167 RPL22; CDC42; RPL11; CAP1; RPS8; RPL5; RPS27; RPS7; RPS27A; RPL31; RPL37A; RPL32; RPL15; RPSA; RPL14; RPL29; RPL24; RPL22L1; RPL35A; RPL9; RPL34; RPS3A; RPL37; RPS23; RPS14; PSMB8; PSMB9; RPS18; RPS10; RPL10A; RPS12; RPS4X; RPL36A; RPL39; RPL10; RPS20; RPL7; RPL30; PABPC1; RPL8; RPS6; RPL35; RPL12; RPL7A; RPLP2; RPL27A; RPS13; RPS3; RPS25; RPS24; RPL41; RPL6; RPLP0; RPL21; PSME2; RPS29; RPL4; RPLP1; RPS17; RPS2; TCEB2; RPS15A; RPL13; PSMB6; PFN1; RPL26; RPL23A; PSMB3; RPL23; RPL19; RPL27; RPL38; RPL17; PSMA7; RPS21; RPS15; RPL36; RPS28; RPL18A; UBA52; RPS16; RPS19; RPL18; RPL13A; RPS11; RPS9; RPL28; RPS5; RPL3
R-HSA-6791226 Major pathway of rRNA processing in the nucleolus and cytosol 7.14 0.00e+00 0.00e+00 79/158 RPL22; RPL11; RPS8; RPL5; RPS27; RPS7; RPS27A; RPL31; RPL37A; NCL; RPL32; RPL15; RPSA; RPL14; RPL29; RPL24; RPL22L1; RPL35A; RPL9; RPL34; RPS3A; RPL37; RPS23; RPS14; RPS18; RPS10; RPL10A; RPS12; RPS4X; RPL36A; RPL39; RPL10; RPS20; RPL7; RPL30; RPL8; RPS6; RPL35; RPL12; RPL7A; RPLP2; RPL27A; RPS13; RPS3; RPS25; RPS24; RPL41; RPL6; RPLP0; RPL21; RPS29; RPL4; RPLP1; RPS17; RPS2; RPS15A; RPL13; RPL26; RPL23A; RPL23; RPL19; RPL27; RPL38; RPL17; RPS21; RPS15; RPL36; RPS28; RPL18A; UBA52; RPS16; RPS19; RPL18; RPL13A; RPS11; RPS9; RPL28; RPS5; RPL3
R-HSA-3928662 EPHB-mediated forward signaling 7.14 2.38e-07 5.87e-06 10/20 CDC42; ARPC5; ACTR3; ARPC2; ARPC4; ACTB; ARPC1B; CFL1; ARPC3; ACTG1
R-HSA-8868773 rRNA processing in the nucleus and cytosol 6.71 0.00e+00 0.00e+00 79/168 RPL22; RPL11; RPS8; RPL5; RPS27; RPS7; RPS27A; RPL31; RPL37A; NCL; RPL32; RPL15; RPSA; RPL14; RPL29; RPL24; RPL22L1; RPL35A; RPL9; RPL34; RPS3A; RPL37; RPS23; RPS14; RPS18; RPS10; RPL10A; RPS12; RPS4X; RPL36A; RPL39; RPL10; RPS20; RPL7; RPL30; RPL8; RPS6; RPL35; RPL12; RPL7A; RPLP2; RPL27A; RPS13; RPS3; RPS25; RPS24; RPL41; RPL6; RPLP0; RPL21; RPS29; RPL4; RPLP1; RPS17; RPS2; RPS15A; RPL13; RPL26; RPL23A; RPL23; RPL19; RPL27; RPL38; RPL17; RPS21; RPS15; RPL36; RPS28; RPL18A; UBA52; RPS16; RPS19; RPL18; RPL13A; RPS11; RPS9; RPL28; RPS5; RPL3
R-HSA-5627123 RHO GTPases activate PAKs 6.66 3.03e-05 5.85e-04 7/15 CDC42; FLNA; MYL6; CALM1; MYL12A; CALM3; MYH9
R-HSA-8876725 Protein methylation 6.59 1.26e-04 2.15e-03 6/13 EEF1A1; HSPA8; CALM1; RPS2; EEF2; CALM3
R-HSA-72312 rRNA processing 6.44 0.00e+00 0.00e+00 79/175 RPL22; RPL11; RPS8; RPL5; RPS27; RPS7; RPS27A; RPL31; RPL37A; NCL; RPL32; RPL15; RPSA; RPL14; RPL29; RPL24; RPL22L1; RPL35A; RPL9; RPL34; RPS3A; RPL37; RPS23; RPS14; RPS18; RPS10; RPL10A; RPS12; RPS4X; RPL36A; RPL39; RPL10; RPS20; RPL7; RPL30; RPL8; RPS6; RPL35; RPL12; RPL7A; RPLP2; RPL27A; RPS13; RPS3; RPS25; RPS24; RPL41; RPL6; RPLP0; RPL21; RPS29; RPL4; RPLP1; RPS17; RPS2; RPS15A; RPL13; RPL26; RPL23A; RPL23; RPL19; RPL27; RPL38; RPL17; RPS21; RPS15; RPL36; RPS28; RPL18A; UBA52; RPS16; RPS19; RPL18; RPL13A; RPS11; RPS9; RPL28; RPS5; RPL3
R-HSA-445355 Smooth Muscle Contraction 6.34 1.24e-05 2.67e-04 8/18 TPM3; TLN1; MYL6; CALM1; ANXA2; MYL12A; TPM4; CALM3
R-HSA-422475 Axon guidance 5.89 0.00e+00 0.00e+00 106/257 RPL22; CDC42; RPL11; CAP1; RPS8; RPL5; RPS27; ARPC5; RPS7; RPS27A; RPL31; ACTR3; RPL37A; ARPC2; ARPC4; RPL32; RPL15; RPSA; RPL14; RPL29; RPL24; RPL22L1; RPL35A; RPL9; RPL34; RPS3A; RPL37; RPS23; RPS14; PSMB8; PSMB9; RPS18; RPS10; RPL10A; HSP90AB1; RPS12; ACTB; ARPC1B; RPS4X; RPL36A; RPL39; RPL10; DOK2; RPS20; RPL7; RPL30; PABPC1; RPL8; RPS6; TLN1; RPL35; RPL12; RPL7A; RPLP2; RPL27A; RPS13; CFL1; RPS3; RPS25; HSPA8; RPS24; RPL41; MYL6; ARPC3; RPL6; RPLP0; RPL21; PSME2; RPS29; RPL4; RPLP1; RPS17; RPS2; TCEB2; RPS15A; RPL13; PSMB6; PFN1; RPL26; RPL23A; PSMB3; RPL23; RPL19; RPL27; RPL38; ACTG1; MYL12A; RPL17; PSMA7; RPS21; RPS15; RPL36; RPS28; RPL18A; UBA52; RPS16; RPS19; AP2S1; RPL18; RPL13A; RPS11; RPS9; RPL28; RPS5; MYH9; RPL3
R-HSA-71291 Metabolism of amino acids and derivatives 5.86 0.00e+00 0.00e+00 87/212 RPL22; RPL11; RPS8; RPL5; RPS27; RPS7; RPS27A; RPL31; RPL37A; RPL32; RPL15; RPSA; RPL14; RPL29; RPL24; RPL22L1; RPL35A; RPL9; RPL34; RPS3A; RPL37; RPS23; RPS14; PSMB8; PSMB9; RPS18; RPS10; RPL10A; RPS12; RPS4X; RPL36A; RPL39; RPL10; RPS20; RPL7; RPL30; RPL8; RPS6; PSAT1; RPL35; RPL12; RPL7A; RPLP2; RPL27A; RPS13; RPS3; RPS25; RPS24; RPL41; RPL6; RPLP0; RPL21; PSME2; RPS29; RPL4; RPLP1; RPS17; RPS2; RPS15A; RPL13; PSMB6; RPL26; RPL23A; PSMB3; RPL23; RPL19; RPL27; RPL38; PYCR1; RPL17; PSMA7; RPS21; RPS15; OAZ1; RPL36; RPS28; RPL18A; UBA52; RPS16; RPS19; RPL18; RPL13A; RPS11; RPS9; RPL28; RPS5; RPL3
R-HSA-202433 Generation of second messenger molecules 5.35 1.83e-05 3.85e-04 9/24 LCK; HLA-DRA; HLA-DRB5; HLA-DRB1; HLA-DQA1; HLA-DQB1; HLA-DPA1; HLA-DPB1; CD3D
R-HSA-2682334 EPH-Ephrin signaling 5.26 1.03e-07 2.61e-06 14/38 CDC42; ARPC5; ACTR3; ARPC2; ARPC4; ACTB; ARPC1B; CFL1; MYL6; ARPC3; ACTG1; MYL12A; AP2S1; MYH9
R-HSA-5663213 RHO GTPases Activate WASPs and WAVEs 5.14 2.68e-05 5.40e-04 9/25 CDC42; ARPC5; ACTR3; ARPC2; ARPC4; ACTB; ARPC1B; ARPC3; ACTG1
R-HSA-72766 Translation 4.74 0.00e+00 0.00e+00 88/265 RPL22; RPL11; RPS8; RPL5; RPS27; RPS7; RPS27A; RPL31; EEF1B2; RPL37A; RPL32; RPL15; RPSA; RPL14; RPL29; RPL24; RPL22L1; RPL35A; RPL9; RPL34; RPS3A; RPL37; RPS23; RPS14; RPS18; RPS10; RPL10A; EEF1A1; RPS12; RPS4X; RPL36A; RPL39; RPL10; RPS20; RPL7; RPL30; PABPC1; EIF3E; EEF1D; RPL8; RPS6; SEC61B; RPL35; RPL12; RPL7A; RPLP2; RPL27A; RPS13; EIF3M; RPS3; RPS25; PPA1; RPS24; RPL41; RPL6; RPLP0; RPL21; RPS29; SRP14; RPL4; RPLP1; RPS17; RPS2; RPS15A; RPL13; RPL26; RPL23A; RPL23; RPL19; RPL27; RPL38; RPL17; RPS21; RPS15; EEF2; RPL36; RPS28; RPL18A; UBA52; RPS16; RPS19; RPL18; RPL13A; RPS11; RPS9; RPL28; RPS5; RPL3
R-HSA-2029482 Regulation of actin dynamics for phagocytic cup formation 4.63 4.16e-06 9.45e-05 12/37 CDC42; ARPC5; ACTR3; ARPC2; ARPC4; HSP90AB1; ACTB; ARPC1B; CFL1; ARPC3; ACTG1; MYH9
R-HSA-5663205 Infectious disease 4.62 0.00e+00 0.00e+00 99/306 RPL22; RPL11; LCK; RPS8; RPL5; RPS27; RPS7; RPS27A; CD8B; RPL31; RPL37A; RPL32; RPL15; RPSA; RPL14; RPL29; RPL24; RPL22L1; RPL35A; RPL9; RPL34; RPS3A; RPL37; RPS23; SKP1; RPS14; NPM1; PSMB8; PSMB9; RPS18; RPS10; RPL10A; HSP90AB1; RPS12; PPIA; SLC25A6; RPS4X; RPL36A; RPL39; RPL10; RPS20; RPL7; RPL30; RPL8; RPS6; RPL35; RPL12; RPL7A; RPLP2; POLR2L; RPL27A; RPS13; RPS3; RPS25; RPS24; RPL41; RPL6; RPLP0; RPL21; PSME2; RPS29; CALM1; B2M; RPL4; RPLP1; RPS17; RPS2; TCEB2; RPS15A; RPL13; PSMB6; RPL26; RPL23A; PSMB3; RPL23; RPL19; RPL27; RPL38; RPL17; PSMA7; RPS21; RPS15; EEF2; RPL36; RPS28; RPL18A; UBA52; RPS16; RPS19; CALM3; AP2S1; RPL18; RPL13A; RPS11; RPS9; RPL28; RPS5; CHMP2A; RPL3
R-HSA-1266738 Developmental Biology 4.56 0.00e+00 0.00e+00 113/354 RPL22; CDC42; RPL11; CAP1; RPS8; RPL5; RPS27; ARPC5; H3F3A; RPS7; RPS27A; RPL31; ACTR3; RPL37A; ARPC2; ARPC4; RPL32; RPL15; RPSA; RPL14; RPL29; RPL24; RPL22L1; RPL35A; RPL9; RPL34; RPS3A; RPL37; RPS23; RPS14; PSMB8; PSMB9; RPS18; RPS10; RPL10A; CCND3; HSP90AB1; RPS12; ACTB; H2AFV; ARPC1B; RPS4X; RPL36A; RPL39; RPL10; DOK2; RPS20; RPL7; RPL30; PABPC1; RPL8; RPS6; TLN1; RPL35; RPL12; RPL7A; RPLP2; POLR2L; RPL27A; RPS13; CFL1; DRAP1; RPS3; RPS25; HSPA8; RPS24; KRT7; RPL41; MYL6; ARPC3; RPL6; RPLP0; RPL21; PSME2; RPS29; RPL4; RPLP1; RPS17; RPS2; TCEB2; RPS15A; RPL13; PSMB6; PFN1; RPL26; RPL23A; PSMB3; RPL23; RPL19; RPL27; RPL38; H3F3B; ACTG1; MYL12A; RPL17; PSMA7; RPS21; RPS15; RPL36; RPS28; RPL18A; UBA52; RPS16; RPS19; AP2S1; RPL18; RPL13A; RPS11; RPS9; RPL28; RPS5; MYH9; RPL3
R-HSA-5626467 RHO GTPases activate IQGAPs 4.46 3.74e-03 4.19e-02 5/16 CDC42; ACTB; CALM1; ACTG1; CALM3
R-HSA-877300 Interferon gamma signaling 4.34 1.53e-06 3.57e-05 14/46 HLA-A; HLA-C; HLA-B; HLA-DRA; HLA-DRB5; HLA-DRB1; HLA-DQA1; HLA-DQB1; HLA-DPA1; HLA-DPB1; PTPN6; B2M; SOCS1; MT2A
R-HSA-5625740 RHO GTPases activate PKNs 3.94 6.14e-04 9.38e-03 8/29 H3F3A; H2AFV; YWHAZ; MYL6; H3F3B; MYL12A; YWHAB; MYH9
R-HSA-2029480 Fcgamma receptor (FCGR) dependent phagocytosis 3.89 3.03e-05 5.85e-04 12/44 CDC42; ARPC5; ACTR3; ARPC2; ARPC4; HSP90AB1; ACTB; ARPC1B; CFL1; ARPC3; ACTG1; MYH9
R-HSA-388841 Costimulation by the CD28 family 3.74 9.83e-05 1.75e-03 11/42 CDC42; LCK; HLA-DRA; HLA-DRB5; HLA-DRB1; HLA-DQA1; HLA-DQB1; HLA-DPA1; HLA-DPB1; CD3D; PTPN6
R-HSA-373755 Semaphorin interactions 3.72 4.08e-03 4.52e-02 6/23 HSP90AB1; TLN1; CFL1; MYL6; MYL12A; MYH9
R-HSA-8950505 Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation 3.68 9.97e-04 1.33e-02 8/31 CDC42; HNRNPA2B1; PPIA; CFL1; RPLP0; LCP1; PSME2; ANXA2
R-HSA-198933 Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell 3.38 9.52e-04 1.32e-02 9/38 SELL; CD8B; HLA-A; HLA-C; HLA-B; CD99; CD3D; B2M; ITGB2
R-HSA-9020591 Interleukin-12 signaling 3.26 2.33e-03 2.81e-02 8/35 CDC42; HNRNPA2B1; PPIA; CFL1; RPLP0; LCP1; PSME2; ANXA2
R-HSA-202424 Downstream TCR signaling 3.25 5.22e-06 1.16e-04 18/79 LCK; RPS27A; SKP1; HLA-DRA; HLA-DRB5; HLA-DRB1; HLA-DQA1; HLA-DQB1; PSMB8; PSMB9; HLA-DPA1; HLA-DPB1; CD3D; PSME2; PSMB6; PSMB3; PSMA7; UBA52
R-HSA-397014 Muscle contraction 3.13 1.70e-03 2.09e-02 9/41 TPM3; TLN1; VIM; MYL6; CALM1; ANXA2; MYL12A; TPM4; CALM3
R-HSA-1236975 Antigen processing-Cross presentation 2.97 9.88e-05 1.75e-03 15/72 RPS27A; VAMP8; HLA-A; HLA-C; HLA-B; PSMB8; PSMB9; SEC61B; PSME2; B2M; CYBA; PSMB6; PSMB3; PSMA7; UBA52
R-HSA-114608 Platelet degranulation 2.97 1.45e-03 1.84e-02 10/48 CAP1; WDR1; PPIA; TMSB4X; FLNA; TLN1; CFL1; CALM1; PFN1; CALM3
R-HSA-1236974 ER-Phagosome pathway 2.94 1.93e-04 3.17e-03 14/68 RPS27A; VAMP8; HLA-A; HLA-C; HLA-B; PSMB8; PSMB9; SEC61B; PSME2; B2M; PSMB6; PSMB3; PSMA7; UBA52
R-HSA-5628897 TP53 Regulates Metabolic Genes 2.81 8.54e-04 1.20e-02 12/61 PRDX1; COX5B; NDUFA4; COX7B; COX6C; YWHAZ; COX8A; COX6A1; YWHAB; PRDX2; COX6B1; MT-CO3
R-HSA-76005 Response to elevated platelet cytosolic Ca2+ 2.74 2.74e-03 3.11e-02 10/52 CAP1; WDR1; PPIA; TMSB4X; FLNA; TLN1; CFL1; CALM1; PFN1; CALM3
R-HSA-450408 AUF1 (hnRNP D0) binds and destabilizes mRNA 2.74 2.74e-03 3.11e-02 10/52 RPS27A; PSMB8; PSMB9; PABPC1; HSPA8; PSME2; PSMB6; PSMB3; PSMA7; UBA52
R-HSA-9604323 Negative regulation of NOTCH4 signaling 2.74 2.74e-03 3.11e-02 10/52 RPS27A; SKP1; PSMB8; PSMB9; YWHAZ; PSME2; PSMB6; PSMB3; PSMA7; UBA52
R-HSA-180534 Vpu mediated degradation of CD4 2.73 4.56e-03 4.81e-02 9/47 RPS27A; SKP1; PSMB8; PSMB9; PSME2; PSMB6; PSMB3; PSMA7; UBA52
R-HSA-202403 TCR signaling 2.70 7.54e-05 1.39e-03 18/95 LCK; RPS27A; SKP1; HLA-DRA; HLA-DRB5; HLA-DRB1; HLA-DQA1; HLA-DQB1; PSMB8; PSMB9; HLA-DPA1; HLA-DPB1; CD3D; PSME2; PSMB6; PSMB3; PSMA7; UBA52
R-HSA-8856828 Clathrin-mediated endocytosis 2.63 6.47e-04 9.71e-03 14/76 ARPC5; RPS27A; VAMP8; ACTR3; ARPC2; ARPC4; ACTB; CD3D; HSPA8; ARPC3; NEDD8; ACTG1; UBA52; AP2S1
R-HSA-163200 Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. 2.57 6.36e-05 1.20e-03 20/111 COX5B; UQCRQ; NDUFA2; NDUFA4; ATP5J2; NDUFB2; COX7B; NDUFA1; COX6C; COX8A; ATP5L; NDUFB8; NDUFA12; COX6A1; ATP5E; NDUFB7; COX6B1; ATP5J; MT-CO3; MT-CYB
R-HSA-1168372 Downstream signaling events of B Cell Receptor (BCR) 2.51 1.59e-03 1.98e-02 13/74 RPS27A; SKP1; PSMB8; PSMB9; PPIA; PSME2; CALM1; PSMB6; PSMB3; FKBP1A; PSMA7; UBA52; CALM3
R-HSA-611105 Respiratory electron transport 2.46 5.98e-04 9.29e-03 16/93 COX5B; UQCRQ; NDUFA2; NDUFA4; NDUFB2; COX7B; NDUFA1; COX6C; COX8A; NDUFB8; NDUFA12; COX6A1; NDUFB7; COX6B1; MT-CO3; MT-CYB
R-HSA-4086400 PCP/CE pathway 2.45 4.29e-03 4.58e-02 11/64 RPS27A; PSMB8; PSMB9; PSME2; PSMB6; PFN1; PSMB3; PSMA7; UBA52; AP2S1; RAC2
R-HSA-8939236 RUNX1 regulates transcription of genes involved in differentiation of HSCs 2.45 4.29e-03 4.58e-02 11/64 H3F3A; RPS27A; PSMB8; PSMB9; H2AFV; PSME2; PSMB6; PSMB3; H3F3B; PSMA7; UBA52
R-HSA-913531 Interferon Signaling 2.40 3.65e-04 5.77e-03 18/107 RPS27A; HLA-A; HLA-C; HLA-B; HLA-DRA; HLA-DRB5; HLA-DRB1; HLA-DQA1; HLA-DQB1; PSMB8; HLA-DPA1; HLA-DPB1; FLNA; PTPN6; B2M; SOCS1; MT2A; UBA52
R-HSA-76002 Platelet activation, signaling and aggregation 2.33 7.48e-04 1.10e-02 17/104 CDC42; LCK; CAP1; GNG5; GNAI2; WDR1; PPIA; TMSB4X; FLNA; YWHAZ; TLN1; CFL1; PTPN6; CALM1; PFN1; CALM3; RAC2
R-HSA-3858494 Beta-catenin independent WNT signaling 2.30 2.53e-03 2.99e-02 14/87 GNG5; RPS27A; PSMB8; PSMB9; PSME2; CALM1; PSMB6; PFN1; PSMB3; PSMA7; UBA52; CALM3; AP2S1; RAC2
R-HSA-162909 Host Interactions of HIV factors 2.21 1.43e-03 1.84e-02 17/110 LCK; RPS27A; CD8B; SKP1; NPM1; PSMB8; PSMB9; PPIA; SLC25A6; PSME2; B2M; TCEB2; PSMB6; PSMB3; PSMA7; UBA52; AP2S1
R-HSA-1428517 The citric acid (TCA) cycle and respiratory electron transport 2.20 3.11e-04 5.02e-03 22/143 COX5B; UQCRQ; NDUFA2; NDUFA4; ATP5J2; NDUFB2; COX7B; NDUFA1; COX6C; COX8A; ATP5L; NDUFB8; LDHB; NDUFA12; COX6A1; IDH2; ATP5E; NDUFB7; COX6B1; ATP5J; MT-CO3; MT-CYB
R-HSA-983705 Signaling by the B Cell Receptor (BCR) 2.17 4.29e-03 4.58e-02 14/92 RPS27A; SKP1; PSMB8; PSMB9; PPIA; PTPN6; PSME2; CALM1; PSMB6; PSMB3; FKBP1A; PSMA7; UBA52; CALM3
R-HSA-195258 RHO GTPase Effectors 2.15 1.71e-04 2.86e-03 25/166 CDC42; RPS27; ARPC5; H3F3A; ACTR3; ARPC2; ARPC4; ACTB; H2AFV; ARPC1B; FLNA; YWHAZ; CFL1; MYL6; ARPC3; CALM1; CYBA; PFN1; H3F3B; ACTG1; MYL12A; YWHAB; CALM3; MYH9; RAC2
Factor 9 : 23 significant Reactome pathways
GeneSet description enrichRatio pValue FDR GeneRatio geneSymbols
R-HSA-202430 Translocation of ZAP-70 to Immunological synapse 18.40 2.66e-08 7.86e-06 7/14 HLA-DRA; HLA-DRB5; HLA-DRB1; HLA-DQA1; HLA-DQB1; HLA-DPA1; HLA-DPB1
R-HSA-389948 PD-1 signaling 17.10 4.88e-08 1.08e-05 7/15 HLA-DRA; HLA-DRB5; HLA-DRB1; HLA-DQA1; HLA-DQB1; HLA-DPA1; HLA-DPB1
R-HSA-202427 Phosphorylation of CD3 and TCR zeta chains 16.10 8.48e-08 1.50e-05 7/16 HLA-DRA; HLA-DRB5; HLA-DRB1; HLA-DQA1; HLA-DQB1; HLA-DPA1; HLA-DPB1
R-HSA-5626467 RHO GTPases activate IQGAPs 13.80 2.26e-06 2.51e-04 6/16 TUBA4A; ACTB; TUBA1B; CALM1; ACTG1
R-HSA-445355 Smooth Muscle Contraction 12.20 5.02e-06 4.45e-04 6/18 ITGA1; CALM1; ANXA2; MYL12A; TPM4
R-HSA-6783783 Interleukin-10 signaling 12.20 3.29e-05 2.40e-03 5/15 CCL5; CCL3; CCL4; CCL3L3
R-HSA-202433 Generation of second messenger molecules 12.20 1.18e-07 1.74e-05 8/24 HLA-DRA; HLA-DRB5; HLA-DRB1; HLA-DQA1; HLA-DQB1; HLA-DPA1; HLA-DPB1; LAT
R-HSA-157858 Gap junction trafficking and regulation 12.20 2.17e-04 9.62e-03 4/12 TUBA4A; ACTB; TUBA1B; ACTG1
R-HSA-190828 Gap junction trafficking 12.20 2.17e-04 9.62e-03 4/12 TUBA4A; ACTB; TUBA1B; ACTG1
R-HSA-877300 Interferon gamma signaling 8.78 2.15e-08 7.86e-06 11/46 GBP2; HLA-E; HLA-DRA; HLA-DRB5; HLA-DRB1; HLA-DQA1; HLA-DQB1; HLA-DPA1; HLA-DPB1; SOCS1; MT2A
R-HSA-397014 Muscle contraction 6.27 9.51e-05 5.34e-03 7/41 ITGA1; VIM; CALM1; ANXA2; MYL12A; TPM4
R-HSA-388841 Costimulation by the CD28 family 6.12 1.12e-04 5.82e-03 7/42 HLA-DRA; HLA-DRB5; HLA-DRB1; HLA-DQA1; HLA-DQB1; HLA-DPA1; HLA-DPB1
R-HSA-114608 Platelet degranulation 6.12 3.53e-05 2.40e-03 8/48 TAGLN2; TUBA4A; TMSB4X; CTSW; CD9; CALM1; PFN1
R-HSA-76005 Response to elevated platelet cytosolic Ca2+ 5.65 6.42e-05 4.07e-03 8/52 TAGLN2; TUBA4A; TMSB4X; CTSW; CD9; CALM1; PFN1
R-HSA-2132295 MHC class II antigen presentation 5.61 2.71e-06 2.66e-04 11/72 TUBA4A; CD74; HLA-DRA; HLA-DRB5; HLA-DRB1; HLA-DQA1; HLA-DQB1; HLA-DMB; HLA-DPA1; HLA-DPB1; TUBA1B
R-HSA-1445148 Translocation of SLC2A4 (GLUT4) to the plasma membrane 5.47 2.33e-04 9.81e-03 7/47 TUBA4A; ACTB; YWHAZ; TUBA1B; CALM1; ACTG1
R-HSA-373760 L1CAM interactions 5.25 8.34e-04 3.21e-02 6/42 TUBA4A; ITGA1; ACTB; ANK3; TUBA1B; ACTG1
R-HSA-913531 Interferon Signaling 4.12 2.51e-05 2.02e-03 12/107 GBP2; HLA-E; HLA-DRA; HLA-DRB5; HLA-DRB1; HLA-DQA1; HLA-DQB1; HLA-DPA1; HLA-DPB1; SOCS1; MT2A; BST2
R-HSA-76002 Platelet activation, signaling and aggregation 3.88 9.65e-05 5.34e-03 11/104 TAGLN2; TUBA4A; TMSB4X; YWHAZ; RASGRP2; CTSW; CD9; CALM1; LAT; PFN1
R-HSA-109582 Hemostasis 3.43 7.36e-07 9.32e-05 20/214 CD2; S100A10; TAGLN2; TUBA4A; ITGA1; CD74; ACTB; TMSB4X; YWHAZ; RASGRP2; CTSW; JAML; GATA3; CD9; TUBA1B; CALM1; ANXA2; LAT; PFN1
R-HSA-1280215 Cytokine Signaling in Immune system 3.38 8.05e-10 7.14e-07 30/326 TNFRSF18; GBP2; HAVCR2; SQSTM1; HLA-E; LTB; HLA-DRA; HLA-DRB5; HLA-DRB1; HLA-DQA1; HLA-DQB1; HLA-DPA1; HLA-DPB1; YWHAZ; GATA3; VIM; CD27; ANXA2; RORA; IL32; SOCS1; MT2A; CCL5; CCL3; CCL4; CCL3L3; JUNB; BST2; IL2RB
R-HSA-449147 Signaling by Interleukins 2.71 2.04e-04 9.62e-03 16/217 HAVCR2; SQSTM1; YWHAZ; GATA3; VIM; ANXA2; RORA; IL32; SOCS1; CCL5; CCL3; CCL4; CCL3L3; JUNB; IL2RB
R-HSA-1280218 Adaptive Immune System 2.03 7.74e-04 3.12e-02 22/397 TUBA4A; UBE2F; CD74; HLA-E; HLA-DRA; HLA-DRB5; HLA-DRB1; HLA-DQA1; HLA-DQB1; HLA-DMB; HLA-DPA1; HLA-DPB1; SH2D1A; YWHAZ; RASGRP2; JAML; TUBA1B; CALM1; TCEB2; SOCS1; LAT
Factor 10 : 44 significant Reactome pathways
GeneSet description enrichRatio pValue FDR GeneRatio geneSymbols
R-HSA-156902 Peptide chain elongation 12.60 0.00e+00 0.00e+00 27/85 RPL5; RPS27; RPL31; RPSA; RPL35A; RPL34; RPL37; RPS14; RPS18; RPL10A; RPL7; RPL8; RPL12; RPS3; RPS26; RPLP0; RPL21; RPL36AL; RPS2; RPS15A; RPL23A; RPL38; EEF2; RPS19; RPS9; RPS5; RPL3
R-HSA-5626467 RHO GTPases activate IQGAPs 12.40 3.16e-05 7.56e-04 5/16 CDC42; CTNNB1; ACTB; TUBB4B; ACTG1
R-HSA-156842 Eukaryotic Translation Elongation 12.40 0.00e+00 0.00e+00 27/87 RPL5; RPS27; RPL31; RPSA; RPL35A; RPL34; RPL37; RPS14; RPS18; RPL10A; RPL7; RPL8; RPL12; RPS3; RPS26; RPLP0; RPL21; RPL36AL; RPS2; RPS15A; RPL23A; RPL38; EEF2; RPS19; RPS9; RPS5; RPL3
R-HSA-192823 Viral mRNA Translation 12.20 0.00e+00 0.00e+00 26/85 RPL5; RPS27; RPL31; RPSA; RPL35A; RPL34; RPL37; RPS14; RPS18; RPL10A; RPL7; RPL8; RPL12; RPS3; RPS26; RPLP0; RPL21; RPL36AL; RPS2; RPS15A; RPL23A; RPL38; RPS19; RPS9; RPS5; RPL3
R-HSA-2408557 Selenocysteine synthesis 12.20 0.00e+00 0.00e+00 26/85 RPL5; RPS27; RPL31; RPSA; RPL35A; RPL34; RPL37; RPS14; RPS18; RPL10A; RPL7; RPL8; RPL12; RPS3; RPS26; RPLP0; RPL21; RPL36AL; RPS2; RPS15A; RPL23A; RPL38; RPS19; RPS9; RPS5; RPL3
R-HSA-975956 Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) 12.10 0.00e+00 0.00e+00 27/89 RPL5; RPS27; RPL31; RPSA; RPL35A; RPL34; RPL37; RPS14; RPS18; RPL10A; RPL7; PABPC1; RPL8; RPL12; RPS3; RPS26; RPLP0; RPL21; RPL36AL; RPS2; RPS15A; RPL23A; RPL38; RPS19; RPS9; RPS5; RPL3
R-HSA-3928662 EPHB-mediated forward signaling 11.90 6.26e-06 1.63e-04 6/20 CDC42; ARPC2; ARPC4; ACTB; ARPC1B; ACTG1
R-HSA-72764 Eukaryotic Translation Termination 11.80 0.00e+00 0.00e+00 26/88 RPL5; RPS27; RPL31; RPSA; RPL35A; RPL34; RPL37; RPS14; RPS18; RPL10A; RPL7; RPL8; RPL12; RPS3; RPS26; RPLP0; RPL21; RPL36AL; RPS2; RPS15A; RPL23A; RPL38; RPS19; RPS9; RPS5; RPL3
R-HSA-72689 Formation of a pool of free 40S subunits 10.80 0.00e+00 0.00e+00 26/96 RPL5; RPS27; RPL31; RPSA; RPL35A; RPL34; RPL37; RPS14; RPS18; RPL10A; RPL7; RPL8; RPL12; RPS3; RPS26; RPLP0; RPL21; RPL36AL; RPS2; RPS15A; RPL23A; RPL38; RPS19; RPS9; RPS5; RPL3
R-HSA-156827 L13a-mediated translational silencing of Ceruloplasmin expression 10.50 0.00e+00 0.00e+00 28/106 RPL5; RPS27; RPL31; RPSA; RPL35A; RPL34; RPL37; RPS14; RPS18; RPL10A; EIF2S3; RPL7; PABPC1; RPL8; RPL12; RPS3; RPS26; RPLP0; RPL21; RPL36AL; RPS2; RPS15A; RPL23A; RPL38; RPS19; RPS9; RPS5; RPL3
R-HSA-983170 Antigen Presentation: Folding, assembly and peptide loading of class I MHC 10.50 7.92e-05 1.80e-03 5/19 HLA-F; HLA-A; HLA-C; HLA-B; B2M
R-HSA-2408522 Selenoamino acid metabolism 10.50 0.00e+00 0.00e+00 26/99 RPL5; RPS27; RPL31; RPSA; RPL35A; RPL34; RPL37; RPS14; RPS18; RPL10A; RPL7; RPL8; RPL12; RPS3; RPS26; RPLP0; RPL21; RPL36AL; RPS2; RPS15A; RPL23A; RPL38; RPS19; RPS9; RPS5; RPL3
R-HSA-927802 Nonsense-Mediated Decay (NMD) 10.10 0.00e+00 0.00e+00 27/106 RPL5; RPS27; RPL31; RPSA; RPL35A; RPL34; RPL37; RPS14; RPS18; RPL10A; RPL7; PABPC1; RPL8; RPL12; RPS3; RPS26; RPLP0; RPL21; RPL36AL; RPS2; RPS15A; RPL23A; RPL38; RPS19; RPS9; RPS5; RPL3
R-HSA-975957 Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) 10.10 0.00e+00 0.00e+00 27/106 RPL5; RPS27; RPL31; RPSA; RPL35A; RPL34; RPL37; RPS14; RPS18; RPL10A; RPL7; PABPC1; RPL8; RPL12; RPS3; RPS26; RPLP0; RPL21; RPL36AL; RPS2; RPS15A; RPL23A; RPL38; RPS19; RPS9; RPS5; RPL3
R-HSA-72706 GTP hydrolysis and joining of the 60S ribosomal subunit 10.00 0.00e+00 0.00e+00 27/107 RPL5; RPS27; RPL31; RPSA; RPL35A; RPL34; RPL37; RPS14; RPS18; RPL10A; EIF2S3; RPL7; RPL8; RPL12; RPS3; RPS26; RPLP0; RPL21; RPL36AL; RPS2; RPS15A; RPL23A; RPL38; RPS19; RPS9; RPS5; RPL3
R-HSA-1799339 SRP-dependent cotranslational protein targeting to membrane 10.00 0.00e+00 0.00e+00 27/107 RPL5; RPS27; RPL31; RPSA; RPL35A; RPL34; RPL37; RPS14; RPS18; RPL10A; SSR4; RPL7; RPL8; RPL12; RPS3; RPS26; RPLP0; RPL21; RPL36AL; RPS2; RPS15A; RPL23A; RPL38; RPS19; RPS9; RPS5; RPL3
R-HSA-72695 Formation of the ternary complex, and subsequently, the 43S complex 9.95 1.03e-09 2.95e-08 12/48 RPS27; RPSA; RPS14; RPS18; EIF2S3; RPS3; RPS26; RPS2; RPS15A; RPS19; RPS9; RPS5
R-HSA-72613 Eukaryotic Translation Initiation 9.78 0.00e+00 0.00e+00 28/114 RPL5; RPS27; RPL31; RPSA; RPL35A; RPL34; RPL37; RPS14; RPS18; RPL10A; EIF2S3; RPL7; PABPC1; RPL8; RPL12; RPS3; RPS26; RPLP0; RPL21; RPL36AL; RPS2; RPS15A; RPL23A; RPL38; RPS19; RPS9; RPS5; RPL3
R-HSA-72737 Cap-dependent Translation Initiation 9.78 0.00e+00 0.00e+00 28/114 RPL5; RPS27; RPL31; RPSA; RPL35A; RPL34; RPL37; RPS14; RPS18; RPL10A; EIF2S3; RPL7; PABPC1; RPL8; RPL12; RPS3; RPS26; RPLP0; RPL21; RPL36AL; RPS2; RPS15A; RPL23A; RPL38; RPS19; RPS9; RPS5; RPL3
R-HSA-5663213 RHO GTPases Activate WASPs and WAVEs 9.55 2.58e-05 6.35e-04 6/25 CDC42; ARPC2; ARPC4; ACTB; ARPC1B; ACTG1
R-HSA-72649 Translation initiation complex formation 9.41 4.21e-10 1.29e-08 13/55 RPS27; RPSA; RPS14; RPS18; EIF2S3; PABPC1; RPS3; RPS26; RPS2; RPS15A; RPS19; RPS9; RPS5
R-HSA-72662 Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S 9.24 5.37e-10 1.59e-08 13/56 RPS27; RPSA; RPS14; RPS18; EIF2S3; PABPC1; RPS3; RPS26; RPS2; RPS15A; RPS19; RPS9; RPS5
R-HSA-72702 Ribosomal scanning and start codon recognition 8.69 5.63e-09 1.56e-07 12/55 RPS27; RPSA; RPS14; RPS18; EIF2S3; RPS3; RPS26; RPS2; RPS15A; RPS19; RPS9; RPS5
R-HSA-2029482 Regulation of actin dynamics for phagocytic cup formation 8.61 2.50e-06 6.71e-05 8/37 CDC42; ARPC2; ARPC4; HSP90AB1; ACTB; ARPC1B; CD3G; ACTG1
R-HSA-168273 Influenza Viral RNA Transcription and Replication 8.55 0.00e+00 0.00e+00 26/121 RPL5; RPS27; RPL31; RPSA; RPL35A; RPL34; RPL37; RPS14; RPS18; RPL10A; RPL7; RPL8; RPL12; RPS3; RPS26; RPLP0; RPL21; RPL36AL; RPS2; RPS15A; RPL23A; RPL38; RPS19; RPS9; RPS5; RPL3
R-HSA-389957 Prefoldin mediated transfer of substrate to CCT/TriC 8.38 1.08e-03 2.18e-02 4/19 ACTB; TUBB4B; PFDN5; CCT8
R-HSA-389958 Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding 7.96 1.33e-03 2.62e-02 4/20 ACTB; TUBB4B; PFDN5; CCT8
R-HSA-168255 Influenza Life Cycle 7.96 0.00e+00 0.00e+00 26/130 RPL5; RPS27; RPL31; RPSA; RPL35A; RPL34; RPL37; RPS14; RPS18; RPL10A; RPL7; RPL8; RPL12; RPS3; RPS26; RPLP0; RPL21; RPL36AL; RPS2; RPS15A; RPL23A; RPL38; RPS19; RPS9; RPS5; RPL3
R-HSA-9010553 Regulation of expression of SLITs and ROBOs 7.58 0.00e+00 0.00e+00 28/147 RPL5; RPS27; RPL31; RPSA; RPL35A; RPL34; RPL37; RPS14; RPS18; RPL10A; RPL7; PABPC1; RPL8; RPL12; RPS3; RPS26; RPLP0; RPL21; RPL36AL; RPS2; RPS15A; UBB; RPL23A; RPL38; RPS19; RPS9; RPS5; RPL3
R-HSA-168254 Influenza Infection 7.45 1.11e-16 4.47e-15 26/139 RPL5; RPS27; RPL31; RPSA; RPL35A; RPL34; RPL37; RPS14; RPS18; RPL10A; RPL7; RPL8; RPL12; RPS3; RPS26; RPLP0; RPL21; RPL36AL; RPS2; RPS15A; RPL23A; RPL38; RPS19; RPS9; RPS5; RPL3
R-HSA-198933 Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell 7.33 3.37e-05 7.87e-04 7/38 HLA-F; HLA-A; HLA-C; HLA-B; CD3D; CD3G; B2M
R-HSA-2029480 Fcgamma receptor (FCGR) dependent phagocytosis 7.24 9.93e-06 2.51e-04 8/44 CDC42; ARPC2; ARPC4; HSP90AB1; ACTB; ARPC1B; CD3G; ACTG1
R-HSA-376176 Signaling by ROBO receptors 6.91 0.00e+00 0.00e+00 29/167 CDC42; RPL5; RPS27; RPL31; RPSA; RPL35A; RPL34; RPL37; RPS14; RPS18; RPL10A; RPL7; PABPC1; RPL8; RPL12; RPS3; RPS26; RPLP0; RPL21; RPL36AL; RPS2; RPS15A; UBB; RPL23A; RPL38; RPS19; RPS9; RPS5; RPL3
R-HSA-6791226 Major pathway of rRNA processing in the nucleolus and cytosol 6.55 2.33e-15 8.61e-14 26/158 RPL5; RPS27; RPL31; RPSA; RPL35A; RPL34; RPL37; RPS14; RPS18; RPL10A; RPL7; RPL8; RPL12; RPS3; RPS26; RPLP0; RPL21; RPL36AL; RPS2; RPS15A; RPL23A; RPL38; RPS19; RPS9; RPS5; RPL3
R-HSA-2682334 EPH-Ephrin signaling 6.29 3.09e-04 6.85e-03 6/38 CDC42; ARPC2; ARPC4; ACTB; ARPC1B; ACTG1
R-HSA-8868773 rRNA processing in the nucleus and cytosol 6.16 1.11e-14 3.93e-13 26/168 RPL5; RPS27; RPL31; RPSA; RPL35A; RPL34; RPL37; RPS14; RPS18; RPL10A; RPL7; RPL8; RPL12; RPS3; RPS26; RPLP0; RPL21; RPL36AL; RPS2; RPS15A; RPL23A; RPL38; RPS19; RPS9; RPS5; RPL3
R-HSA-72312 rRNA processing 5.91 3.06e-14 1.04e-12 26/175 RPL5; RPS27; RPL31; RPSA; RPL35A; RPL34; RPL37; RPS14; RPS18; RPL10A; RPL7; RPL8; RPL12; RPS3; RPS26; RPLP0; RPL21; RPL36AL; RPS2; RPS15A; RPL23A; RPL38; RPS19; RPS9; RPS5; RPL3
R-HSA-422475 Axon guidance 5.73 0.00e+00 0.00e+00 37/257 CDC42; RPL5; RPS27; RPL31; ARPC2; ARPC4; RPSA; RPL35A; RPL34; RPL37; RPS14; RPS18; RPL10A; HSP90AB1; ACTB; ARPC1B; SH3KBP1; RPL7; PABPC1; RPL8; RPL12; TUBB4B; RPS3; RPS26; RPLP0; RPL21; RPL36AL; RPS2; RPS15A; UBB; RPL23A; RPL38; ACTG1; RPS19; RPS9; RPS5; RPL3
R-HSA-71291 Metabolism of amino acids and derivatives 4.88 3.23e-12 1.02e-10 26/212 RPL5; RPS27; RPL31; RPSA; RPL35A; RPL34; RPL37; RPS14; RPS18; RPL10A; RPL7; RPL8; RPL12; RPS3; RPS26; RPLP0; RPL21; RPL36AL; RPS2; RPS15A; RPL23A; RPL38; RPS19; RPS9; RPS5; RPL3
R-HSA-72766 Translation 4.66 5.30e-14 1.74e-12 31/265 RPL5; RPS27; RPL31; RPSA; RPL35A; RPL34; RPL37; RPS14; RPS18; RPL10A; EIF2S3; SSR4; RPL7; PABPC1; RPL8; RPL12; RPS3; PPA1; RPS26; RPLP0; RPL21; RPL36AL; RPS2; RPS15A; RPL23A; RPL38; EEF2; RPS19; RPS9; RPS5; RPL3
R-HSA-5663205 Infectious disease 4.55 1.33e-15 5.13e-14 35/306 RPL5; RPS27; RPL31; RPSA; CTNNB1; RPL35A; RPL34; RPL37; RPS14; NPM1; RPS18; RPL10A; HSP90AB1; SH3KBP1; SLC25A5; TCEA1; RPL7; RPL8; RPL12; RPS3; RPS26; RPLP0; RPL21; RPL36AL; B2M; RPS2; RPS15A; UBB; RPL23A; RPL38; EEF2; RPS19; RPS9; RPS5; RPL3
R-HSA-1266738 Developmental Biology 4.39 0.00e+00 0.00e+00 39/354 CDC42; RPL5; RPS27; RPL31; ARPC2; RQCD1; ARPC4; RPSA; CTNNB1; RPL35A; RPL34; RPL37; RPS14; RPS18; RPL10A; HSP90AB1; ACTB; ARPC1B; SH3KBP1; RPL7; PABPC1; RPL8; RPL12; TUBB4B; RPS3; RPS26; RPLP0; RPL21; RPL36AL; RPS2; RPS15A; UBB; RPL23A; RPL38; ACTG1; RPS19; RPS9; RPS5; RPL3
R-HSA-8856828 Clathrin-mediated endocytosis 4.19 5.45e-04 1.18e-02 8/76 ARPC2; ARPC4; ACTB; SH3KBP1; CD3D; CD3G; UBB; ACTG1
R-HSA-195258 RHO GTPase Effectors 2.88 7.82e-04 1.65e-02 12/166 CDC42; RPS27; PPP1CB; ARPC2; ARPC4; CTNNB1; ACTB; ARPC1B; TUBB4B; YWHAE; ACTG1; SPC24
Factor 11 : 19 significant Reactome pathways
GeneSet description enrichRatio pValue FDR GeneRatio geneSymbols
R-HSA-5626467 RHO GTPases activate IQGAPs 15.80 9.04e-05 1.33e-02 4/16 CALM2; TUBA1B; TUBA1A; CALM3
R-HSA-512988 Interleukin-3, Interleukin-5 and GM-CSF signaling 10.50 4.80e-04 4.61e-02 4/24 YWHAZ; IL2RA; PTPN6; UBC
R-HSA-6804757 Regulation of TP53 Degradation 9.34 7.65e-04 4.61e-02 4/27 CCNA2; CDK1; UBC; PPP2R5C
R-HSA-6806003 Regulation of TP53 Expression and Degradation 9.00 8.82e-04 4.67e-02 4/28 CCNA2; CDK1; UBC; PPP2R5C
R-HSA-2559582 Senescence-Associated Secretory Phenotype (SASP) 7.00 6.38e-04 4.61e-02 5/45 H2AFZ; CCNA2; H2AFV; UBC; UBE2C
R-HSA-1445148 Translocation of SLC2A4 (GLUT4) to the plasma membrane 6.71 7.81e-04 4.61e-02 5/47 CALM2; YWHAZ; TUBA1B; TUBA1A; CALM3
R-HSA-195258 RHO GTPase Effectors 5.70 2.19e-08 1.94e-05 15/166 CALM2; BRK1; H2AFZ; H2AFV; ARPC1B; YWHAZ; TUBA1B; TUBA1A; EVL; PPP2R5C; RPS27L; CYBA; BIRC5; NDC80; CALM3
R-HSA-174143 APC/C-mediated degradation of cell cycle proteins 5.04 1.06e-03 4.96e-02 6/75 CCNA2; PTTG1; CDK1; UBC; UBE2C; AURKA
R-HSA-453276 Regulation of mitotic cell cycle 5.04 1.06e-03 4.96e-02 6/75 CCNA2; PTTG1; CDK1; UBC; UBE2C; AURKA
R-HSA-2500257 Resolution of Sister Chromatid Cohesion 4.74 5.78e-04 4.61e-02 7/93 CDK1; TUBA1B; TUBA1A; PPP2R5C; RPS27L; BIRC5; NDC80
R-HSA-5663220 RHO GTPases Activate Formins 4.69 6.17e-04 4.61e-02 7/94 TUBA1B; TUBA1A; EVL; PPP2R5C; RPS27L; BIRC5; NDC80
R-HSA-194315 Signaling by Rho GTPases 4.57 4.25e-07 1.88e-04 15/207 CALM2; BRK1; H2AFZ; H2AFV; ARPC1B; YWHAZ; TUBA1B; TUBA1A; EVL; PPP2R5C; RPS27L; CYBA; BIRC5; NDC80; CALM3
R-HSA-5633007 Regulation of TP53 Activity 4.41 8.96e-04 4.67e-02 7/100 CCNA2; TAF7; RPA3; CDK1; UBC; PPP2R5C; AURKA
R-HSA-2467813 Separation of Sister Chromatids 3.78 4.99e-04 4.61e-02 9/150 PTTG1; TUBA1B; TUBA1A; UBC; PPP2R5C; RPS27L; BIRC5; NDC80; UBE2C
R-HSA-68882 Mitotic Anaphase 3.59 7.30e-04 4.61e-02 9/158 PTTG1; TUBA1B; TUBA1A; UBC; PPP2R5C; RPS27L; BIRC5; NDC80; UBE2C
R-HSA-2555396 Mitotic Metaphase and Anaphase 3.57 7.65e-04 4.61e-02 9/159 PTTG1; TUBA1B; TUBA1A; UBC; PPP2R5C; RPS27L; BIRC5; NDC80; UBE2C
R-HSA-68886 M Phase 3.36 4.16e-05 7.37e-03 14/263 H2AFZ; PTTG1; TUBB; H2AFV; CDK1; TUBA1B; TUBA1A; UBC; PPP2R5C; RPS27L; KIF23; BIRC5; NDC80; UBE2C
R-HSA-69278 Cell Cycle, Mitotic 3.17 5.44e-06 1.21e-03 18/358 H2AFZ; CCNA2; PTTG1; TUBB; RPA3; H2AFV; CDK1; TUBA1B; TUBA1A; UBC; PPP2R5C; RPS27L; KIF23; TOP2A; BIRC5; NDC80; UBE2C; AURKA
R-HSA-1640170 Cell Cycle 2.96 3.97e-06 1.17e-03 20/426 H2AFZ; CCNA2; PTTG1; TUBB; CENPW; RPA3; H2AFV; YWHAZ; CDK1; TUBA1B; TUBA1A; UBC; PPP2R5C; RPS27L; KIF23; TOP2A; BIRC5; NDC80; UBE2C; AURKA
Factor 13 : 24 significant Reactome pathways
GeneSet description enrichRatio pValue FDR GeneRatio geneSymbols
R-HSA-202430 Translocation of ZAP-70 to Immunological synapse 10.80 1.27e-07 2.24e-05 8/14 HLA-DRA; HLA-DRB5; HLA-DRB1; HLA-DQA1; HLA-DQB1; HLA-DPA1; HLA-DPB1; CD3D
R-HSA-202427 Phosphorylation of CD3 and TCR zeta chains 10.60 2.35e-08 6.93e-06 9/16 HLA-DRA; HLA-DRB5; HLA-DRB1; HLA-DQA1; HLA-DQB1; HLA-DPA1; HLA-DPB1; PAG1; CD3D
R-HSA-389948 PD-1 signaling 10.00 2.59e-07 3.28e-05 8/15 HLA-DRA; HLA-DRB5; HLA-DRB1; HLA-DQA1; HLA-DQB1; HLA-DPA1; HLA-DPB1; CD3D
R-HSA-375276 Peptide ligand-binding receptors 8.78 4.83e-06 3.89e-04 7/15 XCL2; XCL1; F2R; ANXA1; PMCH; CCL1; CCL5
R-HSA-216083 Integrin cell surface interactions 8.06 4.39e-05 2.75e-03 6/14 ITGA4; CD44; ITGB7; ITGAL; ITGAE; ITGB2
R-HSA-198933 Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell 7.43 2.39e-10 1.06e-07 15/38 SELL; ITGA4; CD96; HLA-E; HLA-C; HLA-B; NCR3; SH2D1A; CD3D; CRTAM; KLRB1; ITGB7; B2M; ITGAL; ITGB2
R-HSA-202433 Generation of second messenger molecules 7.06 1.85e-06 1.82e-04 9/24 HLA-DRA; HLA-DRB5; HLA-DRB1; HLA-DQA1; HLA-DQB1; HLA-DPA1; HLA-DPB1; CD3D; LAT
R-HSA-373076 Class A/1 (Rhodopsin-like receptors) 6.97 5.49e-07 6.08e-05 10/27 XCL2; XCL1; F2R; ANXA1; PMCH; GPR68; CCL1; CCL5; S1PR4; PTGIR
R-HSA-500792 GPCR ligand binding 6.10 2.10e-07 3.10e-05 12/37 XCL2; XCL1; CD55; F2R; ANXA1; PMCH; GPR68; CCL1; CCL5; S1PR4; ADGRE5; PTGIR
R-HSA-877300 Interferon gamma signaling 5.73 4.86e-08 1.08e-05 14/46 GBP2; GBP5; HLA-E; HLA-C; HLA-B; HLA-DRA; HLA-DRB5; HLA-DRB1; HLA-DQA1; HLA-DQB1; HLA-DPA1; HLA-DPB1; CD44; B2M
R-HSA-6785807 Interleukin-4 and Interleukin-13 signaling 5.45 2.47e-06 2.19e-04 11/38 FSCN1; TIMP1; ANXA1; GATA3; VIM; HSP90B1; BATF; HSP90AA1; BCL2L1; OSM; ITGB2
R-HSA-909733 Interferon alpha/beta signaling 4.70 1.93e-04 9.49e-03 8/32 GBP2; HLA-E; HLA-C; HLA-B; IFITM2; ISG20; BST2; IFNAR2
R-HSA-397014 Muscle contraction 4.13 2.24e-04 1.05e-02 9/41 TTN; ITPR1; SRI; ORAI2; ANXA1; VIM; ATP2B1; MYL12A; TPM4
R-HSA-388841 Costimulation by the CD28 family 4.03 2.72e-04 1.21e-02 9/42 HLA-DRA; HLA-DRB5; HLA-DRB1; HLA-DQA1; HLA-DQB1; HLA-DPA1; HLA-DPB1; CD3D; PPP2R5C
R-HSA-1474244 Extracellular matrix organization 3.96 6.80e-04 2.74e-02 8/38 ITGA4; CAST; TIMP1; CD44; ITGB7; ITGAL; ITGAE; ITGB2
R-HSA-202733 Cell surface interactions at the vascular wall 3.58 1.37e-03 4.82e-02 8/42 FCER1G; SELL; GYPC; ITGA4; CD74; CD44; ITGAL; ITGB2
R-HSA-76005 Response to elevated platelet cytosolic Ca2+ 3.26 1.41e-03 4.82e-02 9/52 TTN; ANXA5; FAM3C; TMSB4X; TIMP1; SRGN; PRKCB; PFN1; SOD1
R-HSA-913531 Interferon Signaling 3.17 9.33e-06 6.36e-04 18/107 GBP2; GBP5; HLA-E; HLA-C; HLA-B; HLA-DRA; HLA-DRB5; HLA-DRB1; HLA-DQA1; HLA-DQB1; HLA-DPA1; HLA-DPB1; IFITM2; CD44; B2M; ISG20; BST2; IFNAR2
R-HSA-372790 Signaling by GPCR 2.73 4.66e-05 2.75e-03 19/131 RHOC; XCL2; XCL1; RGS1; CD55; ITPR1; F2R; RGS14; ARHGEF6; ANXA1; PMCH; GPR68; PRKCB; CCL1; CCL5; PDE6G; S1PR4; ADGRE5; PTGIR
R-HSA-1280215 Cytokine Signaling in Immune system 2.71 5.08e-11 4.50e-08 47/326 TNFRSF9; JUN; GBP2; GBP5; TNIP2; IL7R; HLA-E; HLA-C; HLA-B; LTB; HLA-DRA; HLA-DRB5; HLA-DRB1; HLA-DQA1; HLA-DQB1; HLA-DPA1; HLA-DPB1; FSCN1; TIMP1; MSN; ANXA1; IFITM2; CD44; IL10RA; IL2RA; GATA3; VIM; CD27; HSP90B1; PSME1; PSME2; NFKBIA; BATF; HSP90AA1; B2M; ISG20; IL32; LGALS9; CCL5; CCL3; BCL2L1; TNFSF14; BST2; OSM; SOD1; IFNAR2; ITGB2
R-HSA-202403 TCR signaling 2.57 1.34e-03 4.82e-02 13/95 HLA-DRA; HLA-DRB5; HLA-DRB1; HLA-DQA1; HLA-DQB1; HLA-DPA1; HLA-DPB1; PAG1; CD3D; PSME1; PSME2; NFKBIA; LAT
R-HSA-388396 GPCR downstream signalling 2.48 3.89e-04 1.64e-02 17/129 RHOC; XCL2; XCL1; RGS1; ITPR1; F2R; RGS14; ARHGEF6; ANXA1; PMCH; GPR68; PRKCB; CCL1; CCL5; PDE6G; S1PR4; PTGIR
R-HSA-109582 Hemostasis 2.46 5.27e-06 3.89e-04 28/214 S100A10; FCER1G; SELL; GYPC; TTN; ITGA4; ITPR1; ANXA5; F2R; CD74; MYB; SRI; ORAI2; FAM3C; TMSB4X; TIMP1; CD44; GATA3; SRGN; ATP2B1; PPP2R5C; PRKCB; LAT; ITGAL; PFN1; PTGIR; SOD1; ITGB2
R-HSA-449147 Signaling by Interleukins 2.17 1.53e-04 8.50e-03 25/217 JUN; TNIP2; IL7R; FSCN1; TIMP1; MSN; ANXA1; IL10RA; IL2RA; GATA3; VIM; HSP90B1; PSME1; PSME2; NFKBIA; BATF; HSP90AA1; IL32; LGALS9; CCL5; CCL3; BCL2L1; OSM; SOD1; ITGB2
Factor 14 : 24 significant Reactome pathways
GeneSet description enrichRatio pValue FDR GeneRatio geneSymbols
R-HSA-191273 Cholesterol biosynthesis 16.70 2.84e-13 2.52e-10 12/20 DHCR24; FDPS; MSMO1; HMGCS1; ACAT2; EBP; FDFT1; SQLE; DHCR7; IDI1; MVK; MVD
R-HSA-216083 Integrin cell surface interactions 13.90 1.85e-07 1.83e-05 7/14 ITGA4; ITGA1; CD44; ITGAL; ICAM2; ITGB2; COL6A2
R-HSA-202430 Translocation of ZAP-70 to Immunological synapse 13.90 1.85e-07 1.83e-05 7/14 HLA-DRA; HLA-DRB5; HLA-DRB1; HLA-DQA1; HLA-DQB1; HLA-DPA1; HLA-DPB1
R-HSA-389948 PD-1 signaling 13.00 3.37e-07 2.99e-05 7/15 HLA-DRA; HLA-DRB5; HLA-DRB1; HLA-DQA1; HLA-DQB1; HLA-DPA1; HLA-DPB1
R-HSA-202427 Phosphorylation of CD3 and TCR zeta chains 12.20 5.82e-07 4.69e-05 7/16 HLA-DRA; HLA-DRB5; HLA-DRB1; HLA-DQA1; HLA-DQB1; HLA-DPA1; HLA-DPB1
R-HSA-2426168 Activation of gene expression by SREBF (SREBP) 10.40 6.39e-08 8.08e-06 9/24 FDPS; HMGCS1; FDFT1; SQLE; DHCR7; IDI1; SCD; MVK; MVD
R-HSA-198933 Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell 10.20 1.43e-11 6.35e-09 14/38 SLAMF7; SELL; ITGA4; NCR3; KLRB1; CLEC2B; KLRD1; KLRC1; B2M; ITGAL; ICAM2; HCST; LAIR2; ITGB2
R-HSA-1655829 Regulation of cholesterol biosynthesis by SREBP (SREBF) 9.27 4.23e-08 6.24e-06 10/30 FDPS; HMGCS1; INSIG1; FDFT1; SQLE; DHCR7; IDI1; SCD; MVK; MVD
R-HSA-202433 Generation of second messenger molecules 8.11 1.38e-05 7.20e-04 7/24 HLA-DRA; HLA-DRB5; HLA-DRB1; HLA-DQA1; HLA-DQB1; HLA-DPA1; HLA-DPB1
R-HSA-877300 Interferon gamma signaling 7.25 3.93e-08 6.24e-06 12/46 IRF4; HLA-DRA; HLA-DRB5; HLA-DRB1; HLA-DQA1; HLA-DQB1; HLA-DPA1; HLA-DPB1; CD44; B2M; SOCS1; MT2A
R-HSA-373076 Class A/1 (Rhodopsin-like receptors) 7.21 3.24e-05 1.59e-03 7/27 S1PR1; F2R; HRH2; CXCR3; ANXA1; LPAR6; CCL5
R-HSA-8957322 Metabolism of steroids 6.95 4.94e-09 1.10e-06 14/56 DHCR24; FDPS; MSMO1; HMGCS1; ACAT2; INSIG1; EBP; FDFT1; SQLE; DHCR7; IDI1; SCD; MVK; MVD
R-HSA-388841 Costimulation by the CD28 family 6.62 1.43e-06 9.75e-05 10/42 CD28; ICOS; HLA-DRA; HLA-DRB5; HLA-DRB1; HLA-DQA1; HLA-DQB1; HLA-DPA1; HLA-DPB1; FYN
R-HSA-6785807 Interleukin-4 and Interleukin-13 signaling 6.59 5.18e-06 3.06e-04 9/38 S1PR1; IRF4; PIM1; FSCN1; ANXA1; GATA3; SOCS1; OSM; ITGB2
R-HSA-500792 GPCR ligand binding 6.01 3.64e-05 1.70e-03 8/37 S1PR1; CD55; F2R; HRH2; CXCR3; ANXA1; LPAR6; CCL5
R-HSA-202733 Cell surface interactions at the vascular wall 5.30 9.55e-05 4.23e-03 8/42 FCER1G; SELL; ITGA4; CD74; FYN; CD44; ITGAL; ITGB2
R-HSA-1474244 Extracellular matrix organization 5.12 3.30e-04 1.33e-02 7/38 ITGA4; ITGA1; CD44; ITGAL; ICAM2; ITGB2; COL6A2
R-HSA-2132295 MHC class II antigen presentation 5.02 1.09e-06 8.06e-05 13/72 KIF2A; CD74; HLA-DRA; HLA-DRB5; HLA-DRB1; HLA-DQA1; HLA-DQB1; HLA-DMB; HLA-DPA1; HLA-DPB1; CTSC; LAG3; CTSH
R-HSA-913531 Interferon Signaling 3.12 3.81e-04 1.47e-02 12/107 IRF4; HLA-DRA; HLA-DRB5; HLA-DRB1; HLA-DQA1; HLA-DQB1; HLA-DPA1; HLA-DPB1; CD44; B2M; SOCS1; MT2A
R-HSA-1280215 Cytokine Signaling in Immune system 3.07 2.93e-10 8.66e-08 36/326 TNFRSF4; S1PR1; CISH; IL7R; IL6ST; CSF2; IRF4; HLA-DRA; HLA-DRB5; HLA-DRB1; HLA-DQA1; HLA-DQB1; HLA-DPA1; HLA-DPB1; PIM1; FYN; FSCN1; ANXA1; CD44; BIRC3; IL2RA; GATA3; GSTO1; PDCD4; DUSP6; LCP1; B2M; SOCS1; MT2A; CCL5; CCL4L2; CD70; TNFSF14; FLT3LG; OSM; ITGB2
R-HSA-449147 Signaling by Interleukins 2.82 6.44e-06 3.56e-04 22/217 S1PR1; CISH; IL7R; IL6ST; CSF2; IRF4; PIM1; FYN; FSCN1; ANXA1; IL2RA; GATA3; GSTO1; PDCD4; DUSP6; LCP1; SOCS1; CCL5; CCL4L2; FLT3LG; OSM; ITGB2
R-HSA-109582 Hemostasis 2.47 1.84e-04 7.75e-03 19/214 S100A10; FCER1G; SELL; H3F3A; ITGA4; ITGA1; KIF2A; F2R; CD74; SERPINB6; FYN; TMSB4X; CD44; RASGRP2; CTSW; GATA3; CD9; ITGAL; ITGB2
R-HSA-1280218 Adaptive Immune System 2.31 2.13e-06 1.35e-04 33/397 SLAMF7; SELL; ITGA4; CD28; ICOS; UBE2F; KIF2A; CD74; NCR3; HLA-DRA; HLA-DRB5; HLA-DRB1; HLA-DQA1; HLA-DQB1; HLA-DMB; HLA-DPA1; HLA-DPB1; FYN; RASGRP2; CTSC; LAG3; KLRB1; CLEC2B; KLRD1; KLRC1; B2M; CTSH; SOCS1; ITGAL; ICAM2; HCST; LAIR2; ITGB2
R-HSA-556833 Metabolism of lipids 2.19 6.14e-04 2.27e-02 20/254 DHCR24; FDPS; MSMO1; HMGCS1; PLPP1; TNFAIP8; ACAT2; INSIG1; EBP; FDFT1; SQLE; FADS1; RARRES3; DHCR7; IDI1; SCD; GLIPR1; MVK; ALOX5AP; MVD
Factor 15 : 87 significant Reactome pathways
GeneSet description enrichRatio pValue FDR GeneRatio geneSymbols
R-HSA-140342 Apoptosis induced DNA fragmentation 38.20 8.32e-08 1.05e-05 5/11 HIST1H1A; HIST1H1C; HIST1H1E; HIST1H1D; HIST1H1B
R-HSA-211227 Activation of DNA fragmentation factor 38.20 8.32e-08 1.05e-05 5/11 HIST1H1A; HIST1H1C; HIST1H1E; HIST1H1D; HIST1H1B
R-HSA-2559584 Formation of Senescence-Associated Heterochromatin Foci (SAHF) 32.30 2.28e-07 2.24e-05 5/13 HIST1H1A; HIST1H1C; HIST1H1E; HIST1H1D; HIST1H1B
R-HSA-5625886 Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 30.60 5.44e-06 3.86e-04 4/11 HIST2H2AC; HIST1H4C; H2AFX; H3F3B
R-HSA-427359 SIRT1 negatively regulates rRNA expression 28.00 8.08e-06 4.41e-04 4/12 HIST2H2AC; HIST1H4C; H2AFX; H3F3B
R-HSA-5334118 DNA methylation 28.00 8.08e-06 4.41e-04 4/12 HIST2H2AC; HIST1H4C; H2AFX; H3F3B
R-HSA-73728 RNA Polymerase I Promoter Opening 28.00 8.08e-06 4.41e-04 4/12 HIST2H2AC; HIST1H4C; H2AFX; H3F3B
R-HSA-156711 Polo-like kinase mediated events 25.20 1.78e-04 4.05e-03 3/10 CCNB1; CCNB2; PLK1
R-HSA-381033 ATF6 (ATF6-alpha) activates chaperones 25.20 1.78e-04 4.05e-03 3/10 HSPA5; HSP90B1; CALR
R-HSA-2299718 Condensation of Prophase Chromosomes 24.00 9.55e-08 1.06e-05 6/21 HIST2H2AC; CCNB1; HIST1H4C; H2AFX; PLK1; H3F3B
R-HSA-171306 Packaging Of Telomere Ends 21.00 3.21e-04 6.19e-03 3/12 HIST2H2AC; HIST1H4C; H2AFX
R-HSA-162658 Golgi Cisternae Pericentriolar Stack Reorganization 21.00 3.21e-04 6.19e-03 3/12 CCNB1; CCNB2; PLK1
R-HSA-2559586 DNA Damage/Telomere Stress Induced Senescence 19.80 3.02e-09 8.93e-07 8/34 HIST2H2AC; HIST1H1A; HIST1H1C; HIST1H4C; HIST1H1E; HIST1H1D; HIST1H1B; H2AFX
R-HSA-212300 PRC2 methylates histones and DNA 16.80 7.38e-05 2.42e-03 4/20 HIST2H2AC; HIST1H4C; H2AFX; H3F3B
R-HSA-977225 Amyloid fiber formation 16.80 8.45e-06 4.41e-04 5/25 HIST2H2AC; HIST1H4C; H2AFX; UBC; H3F3B
R-HSA-912446 Meiotic recombination 16.20 1.04e-05 4.70e-04 5/26 HIST2H2AC; HIST1H4C; H2AFX; BRCA2; H3F3B
R-HSA-427389 ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression 15.30 1.09e-04 3.15e-03 4/22 HIST2H2AC; HIST1H4C; H2AFX; H3F3B
R-HSA-179409 APC-Cdc20 mediated degradation of Nek2A 15.30 1.09e-04 3.15e-03 4/22 CDC20; NEK2; MAD2L1; UBC
R-HSA-69273 Cyclin A/B1/B2 associated events during G2/M transition 14.00 1.13e-03 1.62e-02 3/18 CCNB1; CCNB2; PLK1
R-HSA-1912408 Pre-NOTCH Transcription and Translation 13.40 1.84e-04 4.09e-03 4/25 HIST2H2AC; HIST1H4C; H2AFX; H3F3B
R-HSA-539107 Activation of E2F1 target genes at G1/S 13.30 1.34e-03 1.82e-02 3/19 RRM2; FBXO5; CDT1
R-HSA-69205 G1/S-Specific Transcription 13.30 1.34e-03 1.82e-02 3/19 RRM2; FBXO5; CDT1
R-HSA-201722 Formation of the beta-catenin:TCF transactivating complex 12.90 2.16e-04 4.56e-03 4/26 HIST2H2AC; HIST1H4C; H2AFX; H3F3B
R-HSA-8936459 RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function 12.90 2.16e-04 4.56e-03 4/26 HIST2H2AC; HIST1H4C; H2AFX; H3F3B
R-HSA-75153 Apoptotic execution phase 12.70 3.52e-05 1.25e-03 5/33 HIST1H1A; HIST1H1C; HIST1H1E; HIST1H1D; HIST1H1B
R-HSA-5689901 Metalloprotease DUBs 12.60 1.56e-03 1.98e-02 3/20 HIST2H2AC; HIST1H2AH; UBC
R-HSA-174048 APC/C:Cdc20 mediated degradation of Cyclin B 12.60 1.56e-03 1.98e-02 3/20 CDC20; CCNB1; UBC
R-HSA-5625740 RHO GTPases activate PKNs 11.60 3.34e-04 6.31e-03 4/29 HIST2H2AC; HIST1H4C; H2AFX; H3F3B
R-HSA-3214858 RMTs methylate histone arginines 11.20 3.83e-04 6.92e-03 4/30 HIST2H2AC; HIST1H4C; HIST1H2AH; H2AFX
R-HSA-5250924 B-WICH complex positively regulates rRNA expression 11.20 3.83e-04 6.92e-03 4/30 HIST2H2AC; HIST1H4C; H2AFX; H3F3B
R-HSA-2559582 Senescence-Associated Secretory Phenotype (SASP) 11.20 1.16e-05 4.89e-04 6/45 HIST2H2AC; HIST1H4C; H2AFX; UBC; H3F3B; CDKN2D
R-HSA-5693606 DNA Double Strand Break Response 10.50 4.93e-04 8.10e-03 4/32 HIST1H4C; H2AFX; UBC; KPNA2
R-HSA-73777 RNA Polymerase I Chain Elongation 10.50 4.93e-04 8.10e-03 4/32 HIST2H2AC; HIST1H4C; H2AFX; H3F3B
R-HSA-606279 Deposition of new CENPA-containing nucleosomes at the centromere 10.20 5.57e-04 8.81e-03 4/33 HIST2H2AC; NPM1; HIST1H4C; H2AFX
R-HSA-774815 Nucleosome assembly 10.20 5.57e-04 8.81e-03 4/33 HIST2H2AC; NPM1; HIST1H4C; H2AFX
R-HSA-1912422 Pre-NOTCH Expression and Processing 9.89 6.25e-04 9.55e-03 4/34 HIST2H2AC; HIST1H4C; H2AFX; H3F3B
R-HSA-5617472 Activation of anterior HOX genes in hindbrain development during early embryogenesis 9.77 1.31e-04 3.31e-03 5/43 HIST2H2AC; HIST1H4C; H2AFX; CTCF; H3F3B
R-HSA-5619507 Activation of HOX genes during differentiation 9.77 1.31e-04 3.31e-03 5/43 HIST2H2AC; HIST1H4C; H2AFX; CTCF; H3F3B
R-HSA-1221632 Meiotic synapsis 9.70 3.38e-03 3.65e-02 3/26 HIST2H2AC; HIST1H4C; H2AFX
R-HSA-1500620 Meiosis 9.55 1.46e-04 3.59e-03 5/44 HIST2H2AC; HIST1H4C; H2AFX; BRCA2; H3F3B
R-HSA-2559580 Oxidative Stress Induced Senescence 9.51 3.04e-05 1.12e-03 6/53 HIST2H2AC; HIST1H4C; H2AFX; UBC; H3F3B; CDKN2D
R-HSA-2559583 Cellular Senescence 9.15 1.36e-08 3.01e-06 11/101 HIST2H2AC; HIST1H1A; HIST1H1C; HIST1H4C; HIST1H1E; HIST1H1D; HIST1H1B; H2AFX; UBC; H3F3B; CDKN2D
R-HSA-3214815 HDACs deacetylate histones 9.00 4.19e-03 4.37e-02 3/28 HIST2H2AC; HIST1H4C; HIST1H2AH
R-HSA-174143 APC/C-mediated degradation of cell cycle proteins 8.96 1.96e-06 1.58e-04 8/75 CDC20; NEK2; MAD2L1; CCNB1; PTTG1; FBXO5; UBC; PLK1
R-HSA-453276 Regulation of mitotic cell cycle 8.96 1.96e-06 1.58e-04 8/75 CDC20; NEK2; MAD2L1; CCNB1; PTTG1; FBXO5; UBC; PLK1
R-HSA-68875 Mitotic Prophase 8.78 1.06e-05 4.70e-04 7/67 HIST2H2AC; CCNB1; HIST1H4C; H2AFX; CCNB2; PLK1; H3F3B
R-HSA-1474165 Reproduction 8.75 2.22e-04 4.58e-03 5/48 HIST2H2AC; HIST1H4C; H2AFX; BRCA2; H3F3B
R-HSA-176814 Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins 8.53 1.29e-05 5.21e-04 7/69 CDC20; NEK2; MAD2L1; CCNB1; PTTG1; UBC; PLK1
R-HSA-5250913 Positive epigenetic regulation of rRNA expression 7.82 1.54e-03 1.98e-02 4/43 HIST2H2AC; HIST1H4C; H2AFX; H3F3B
R-HSA-427413 NoRC negatively regulates rRNA expression 7.64 1.68e-03 2.07e-02 4/44 HIST2H2AC; HIST1H4C; H2AFX; H3F3B
R-HSA-5578749 Transcriptional regulation by small RNAs 7.64 1.68e-03 2.07e-02 4/44 HIST2H2AC; HIST1H4C; H2AFX; H3F3B
R-HSA-5250941 Negative epigenetic regulation of rRNA expression 7.47 1.83e-03 2.13e-02 4/45 HIST2H2AC; HIST1H4C; H2AFX; H3F3B
R-HSA-73854 RNA Polymerase I Promoter Clearance 7.47 1.83e-03 2.13e-02 4/45 HIST2H2AC; HIST1H4C; H2AFX; H3F3B
R-HSA-176409 APC/C:Cdc20 mediated degradation of mitotic proteins 7.42 1.27e-04 3.31e-03 6/68 CDC20; NEK2; MAD2L1; CCNB1; PTTG1; UBC
R-HSA-73864 RNA Polymerase I Transcription 7.31 1.98e-03 2.28e-02 4/46 HIST2H2AC; HIST1H4C; H2AFX; H3F3B
R-HSA-2500257 Resolution of Sister Chromatid Cohesion 7.23 1.01e-05 4.70e-04 8/93 CDC20; NUF2; SPC25; MAD2L1; CCNB1; CDCA5; CCNB2; PLK1
R-HSA-176408 Regulation of APC/C activators between G1/S and early anaphase 7.10 1.62e-04 3.87e-03 6/71 CDC20; MAD2L1; CCNB1; FBXO5; UBC; PLK1
R-HSA-8939236 RUNX1 regulates transcription of genes involved in differentiation of HSCs 6.57 8.59e-04 1.29e-02 5/64 HIST2H2AC; HIST1H4C; H2AFX; UBC; H3F3B
R-HSA-2565942 Regulation of PLK1 Activity at G2/M Transition 6.46 9.23e-04 1.36e-02 5/65 NEK2; CCNB1; UBC; CCNB2; PLK1
R-HSA-9018519 Estrogen-dependent gene expression 6.37 9.89e-04 1.44e-02 5/66 HIST2H2AC; HIST1H4C; H2AFX; KPNA2; H3F3B
R-HSA-211000 Gene Silencing by RNA 6.23 3.59e-03 3.78e-02 4/54 HIST2H2AC; HIST1H4C; H2AFX; H3F3B
R-HSA-5693567 HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) 6.09 1.21e-03 1.70e-02 5/69 HIST1H4C; XRCC2; H2AFX; UBC; BRCA2
R-HSA-8939211 ESR-mediated signaling 5.92 1.38e-03 1.85e-02 5/71 HIST2H2AC; HIST1H4C; H2AFX; KPNA2; H3F3B
R-HSA-5693532 DNA Double-Strand Break Repair 5.80 4.94e-04 8.10e-03 6/87 HIST1H4C; XRCC2; H2AFX; UBC; BRCA2; KPNA2
R-HSA-73886 Chromosome Maintenance 5.80 4.65e-03 4.79e-02 4/58 HIST2H2AC; NPM1; HIST1H4C; H2AFX
R-HSA-5693538 Homology Directed Repair 5.76 1.56e-03 1.98e-02 5/73 HIST1H4C; XRCC2; H2AFX; UBC; BRCA2
R-HSA-141424 Amplification of signal from the kinetochores 5.60 1.76e-03 2.11e-02 5/75 CDC20; NUF2; SPC25; MAD2L1; PLK1
R-HSA-141444 Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal 5.60 1.76e-03 2.11e-02 5/75 CDC20; NUF2; SPC25; MAD2L1; PLK1
R-HSA-68877 Mitotic Prometaphase 5.18 4.02e-05 1.37e-03 9/146 CDC20; NUF2; NEK2; SPC25; MAD2L1; CCNB1; CDCA5; CCNB2; PLK1
R-HSA-69278 Cell Cycle, Mitotic 5.16 8.66e-12 3.84e-09 22/358 CDC20; HIST2H2AC; NUF2; NEK2; RRM2; SPC25; MAD2L1; CCNB1; PTTG1; HMMR; HIST1H4C; FBXO5; ESCO2; CDCA5; H2AFX; UBC; CCNB2; PLK1; GINS2; CDT1; H3F3B; CDKN2D
R-HSA-9006931 Signaling by Nuclear Receptors 5.12 2.62e-03 2.90e-02 5/82 HIST2H2AC; HIST1H4C; H2AFX; KPNA2; H3F3B
R-HSA-68886 M Phase 5.11 1.97e-08 3.50e-06 16/263 CDC20; HIST2H2AC; NUF2; NEK2; SPC25; MAD2L1; CCNB1; PTTG1; HIST1H4C; FBXO5; CDCA5; H2AFX; UBC; CCNB2; PLK1; H3F3B
R-HSA-69618 Mitotic Spindle Checkpoint 4.78 3.57e-03 3.78e-02 5/88 CDC20; NUF2; SPC25; MAD2L1; PLK1
R-HSA-2555396 Mitotic Metaphase and Anaphase 4.76 7.88e-05 2.49e-03 9/159 CDC20; NUF2; SPC25; MAD2L1; PTTG1; FBXO5; CDCA5; UBC; PLK1
R-HSA-1640170 Cell Cycle 4.73 3.75e-12 3.32e-09 24/426 CDC20; HIST2H2AC; NUF2; NEK2; RRM2; SPC25; MAD2L1; CCNB1; PTTG1; HMMR; NPM1; HIST1H4C; FBXO5; ESCO2; CDCA5; H2AFX; UBC; BRCA2; CCNB2; PLK1; GINS2; CDT1; H3F3B; CDKN2D
R-HSA-195258 RHO GTPase Effectors 4.56 1.10e-04 3.15e-03 9/166 CDC20; HIST2H2AC; NUF2; SPC25; MAD2L1; HIST1H4C; H2AFX; PLK1; H3F3B
R-HSA-2467813 Separation of Sister Chromatids 4.48 3.14e-04 6.19e-03 8/150 CDC20; NUF2; SPC25; MAD2L1; PTTG1; CDCA5; UBC; PLK1
R-HSA-5663220 RHO GTPases Activate Formins 4.47 4.75e-03 4.83e-02 5/94 CDC20; NUF2; SPC25; MAD2L1; PLK1
R-HSA-453279 Mitotic G1-G1/S phases 4.42 2.05e-03 2.33e-02 6/114 RRM2; CCNB1; FBXO5; UBC; CDT1; CDKN2D
R-HSA-68882 Mitotic Anaphase 4.26 4.48e-04 7.77e-03 8/158 CDC20; NUF2; SPC25; MAD2L1; PTTG1; CDCA5; UBC; PLK1
R-HSA-109581 Apoptosis 4.24 2.55e-03 2.86e-02 6/119 HIST1H1A; HIST1H1C; HIST1H1E; HIST1H1D; HIST1H1B; UBC
R-HSA-2262752 Cellular responses to stress 4.20 5.67e-06 3.86e-04 13/260 HIST2H2AC; HIST1H1A; HIST1H1C; HIST1H4C; HIST1H1E; HIST1H1D; HIST1H1B; HSPA5; H2AFX; HSPA8; UBC; H3F3B; CDKN2D
R-HSA-5357801 Programmed Cell Death 4.20 2.66e-03 2.91e-02 6/120 HIST1H1A; HIST1H1C; HIST1H1E; HIST1H1D; HIST1H1B; UBC
R-HSA-69620 Cell Cycle Checkpoints 4.02 1.24e-04 3.31e-03 10/209 CDC20; NUF2; SPC25; MAD2L1; CCNB1; HIST1H4C; H2AFX; UBC; CCNB2; PLK1
R-HSA-73894 DNA Repair 3.84 4.06e-04 7.19e-03 9/197 DTL; MSH6; HIST1H4C; XRCC2; H2AFX; UNG; UBC; BRCA2; KPNA2
R-HSA-194315 Signaling by Rho GTPases 3.65 5.85e-04 9.09e-03 9/207 CDC20; HIST2H2AC; NUF2; SPC25; MAD2L1; HIST1H4C; H2AFX; PLK1; H3F3B
R-HSA-8953897 Cellular responses to external stimuli 3.62 2.92e-05 1.12e-03 13/302 HIST2H2AC; HIST1H1A; HIST1H1C; HIST1H4C; HIST1H1E; HIST1H1D; HIST1H1B; HSPA5; H2AFX; HSPA8; UBC; H3F3B; CDKN2D
Factor 16 : 35 significant Reactome pathways
GeneSet description enrichRatio pValue FDR GeneRatio geneSymbols
R-HSA-6803204 TP53 Regulates Transcription of Genes Involved in Cytochrome C Release 18.70 3.72e-05 9.99e-04 4/10 TRIAP1; PMAIP1; BBC3; BAX
R-HSA-156902 Peptide chain elongation 14.80 0.00e+00 0.00e+00 27/85 RPS7; RPL15; RPSA; RPL22L1; RPL9; RPL34; RPS23; RPS14; RPL10A; EEF1A1; RPL10; RPS20; RPL7A; RPL27A; RPL41; RPS29; RPS27L; RPLP1; RPS2; RPL36; RPL18A; UBA52; RPS19; RPL18; RPL28; RPL3
R-HSA-156842 Eukaryotic Translation Elongation 14.50 0.00e+00 0.00e+00 27/87 RPS7; RPL15; RPSA; RPL22L1; RPL9; RPL34; RPS23; RPS14; RPL10A; EEF1A1; RPL10; RPS20; RPL7A; RPL27A; RPL41; RPS29; RPS27L; RPLP1; RPS2; RPL36; RPL18A; UBA52; RPS19; RPL18; RPL28; RPL3
R-HSA-192823 Viral mRNA Translation 14.30 0.00e+00 0.00e+00 26/85 RPS7; RPL15; RPSA; RPL22L1; RPL9; RPL34; RPS23; RPS14; RPL10A; RPL10; RPS20; RPL7A; RPL27A; RPL41; RPS29; RPS27L; RPLP1; RPS2; RPL36; RPL18A; UBA52; RPS19; RPL18; RPL28; RPL3
R-HSA-2408557 Selenocysteine synthesis 14.30 0.00e+00 0.00e+00 26/85 RPS7; RPL15; RPSA; RPL22L1; RPL9; RPL34; RPS23; RPS14; RPL10A; RPL10; RPS20; RPL7A; RPL27A; RPL41; RPS29; RPS27L; RPLP1; RPS2; RPL36; RPL18A; UBA52; RPS19; RPL18; RPL28; RPL3
R-HSA-5669034 TNFs bind their physiological receptors 14.00 1.02e-03 2.58e-02 3/10 TNFRSF18; TNFRSF4; CD70
R-HSA-72764 Eukaryotic Translation Termination 13.80 0.00e+00 0.00e+00 26/88 RPS7; RPL15; RPSA; RPL22L1; RPL9; RPL34; RPS23; RPS14; RPL10A; RPL10; RPS20; RPL7A; RPL27A; RPL41; RPS29; RPS27L; RPLP1; RPS2; RPL36; RPL18A; UBA52; RPS19; RPL18; RPL28; RPL3
R-HSA-975956 Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) 13.60 0.00e+00 0.00e+00 26/89 RPS7; RPL15; RPSA; RPL22L1; RPL9; RPL34; RPS23; RPS14; RPL10A; RPL10; RPS20; RPL7A; RPL27A; RPL41; RPS29; RPS27L; RPLP1; RPS2; RPL36; RPL18A; UBA52; RPS19; RPL18; RPL28; RPL3
R-HSA-72689 Formation of a pool of free 40S subunits 12.60 0.00e+00 0.00e+00 26/96 RPS7; RPL15; RPSA; RPL22L1; RPL9; RPL34; RPS23; RPS14; RPL10A; RPL10; RPS20; RPL7A; RPL27A; RPL41; RPS29; RPS27L; RPLP1; RPS2; RPL36; RPL18A; UBA52; RPS19; RPL18; RPL28; RPL3
R-HSA-2408522 Selenoamino acid metabolism 12.30 0.00e+00 0.00e+00 26/99 RPS7; RPL15; RPSA; RPL22L1; RPL9; RPL34; RPS23; RPS14; RPL10A; RPL10; RPS20; RPL7A; RPL27A; RPL41; RPS29; RPS27L; RPLP1; RPS2; RPL36; RPL18A; UBA52; RPS19; RPL18; RPL28; RPL3
R-HSA-156827 L13a-mediated translational silencing of Ceruloplasmin expression 11.50 0.00e+00 0.00e+00 26/106 RPS7; RPL15; RPSA; RPL22L1; RPL9; RPL34; RPS23; RPS14; RPL10A; RPL10; RPS20; RPL7A; RPL27A; RPL41; RPS29; RPS27L; RPLP1; RPS2; RPL36; RPL18A; UBA52; RPS19; RPL18; RPL28; RPL3
R-HSA-927802 Nonsense-Mediated Decay (NMD) 11.50 0.00e+00 0.00e+00 26/106 RPS7; RPL15; RPSA; RPL22L1; RPL9; RPL34; RPS23; RPS14; RPL10A; RPL10; RPS20; RPL7A; RPL27A; RPL41; RPS29; RPS27L; RPLP1; RPS2; RPL36; RPL18A; UBA52; RPS19; RPL18; RPL28; RPL3
R-HSA-975957 Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) 11.50 0.00e+00 0.00e+00 26/106 RPS7; RPL15; RPSA; RPL22L1; RPL9; RPL34; RPS23; RPS14; RPL10A; RPL10; RPS20; RPL7A; RPL27A; RPL41; RPS29; RPS27L; RPLP1; RPS2; RPL36; RPL18A; UBA52; RPS19; RPL18; RPL28; RPL3
R-HSA-72706 GTP hydrolysis and joining of the 60S ribosomal subunit 11.30 0.00e+00 0.00e+00 26/107 RPS7; RPL15; RPSA; RPL22L1; RPL9; RPL34; RPS23; RPS14; RPL10A; RPL10; RPS20; RPL7A; RPL27A; RPL41; RPS29; RPS27L; RPLP1; RPS2; RPL36; RPL18A; UBA52; RPS19; RPL18; RPL28; RPL3
R-HSA-1799339 SRP-dependent cotranslational protein targeting to membrane 11.30 0.00e+00 0.00e+00 26/107 RPS7; RPL15; RPSA; RPL22L1; RPL9; RPL34; RPS23; RPS14; RPL10A; RPL10; RPS20; RPL7A; RPL27A; RPL41; RPS29; RPS27L; RPLP1; RPS2; RPL36; RPL18A; UBA52; RPS19; RPL18; RPL28; RPL3
R-HSA-72613 Eukaryotic Translation Initiation 10.60 0.00e+00 0.00e+00 26/114 RPS7; RPL15; RPSA; RPL22L1; RPL9; RPL34; RPS23; RPS14; RPL10A; RPL10; RPS20; RPL7A; RPL27A; RPL41; RPS29; RPS27L; RPLP1; RPS2; RPL36; RPL18A; UBA52; RPS19; RPL18; RPL28; RPL3
R-HSA-72737 Cap-dependent Translation Initiation 10.60 0.00e+00 0.00e+00 26/114 RPS7; RPL15; RPSA; RPL22L1; RPL9; RPL34; RPS23; RPS14; RPL10A; RPL10; RPS20; RPL7A; RPL27A; RPL41; RPS29; RPS27L; RPLP1; RPS2; RPL36; RPL18A; UBA52; RPS19; RPL18; RPL28; RPL3
R-HSA-168273 Influenza Viral RNA Transcription and Replication 10.00 0.00e+00 0.00e+00 26/121 RPS7; RPL15; RPSA; RPL22L1; RPL9; RPL34; RPS23; RPS14; RPL10A; RPL10; RPS20; RPL7A; RPL27A; RPL41; RPS29; RPS27L; RPLP1; RPS2; RPL36; RPL18A; UBA52; RPS19; RPL18; RPL28; RPL3
R-HSA-72695 Formation of the ternary complex, and subsequently, the 43S complex 9.73 3.91e-08 1.19e-06 10/48 RPS7; RPSA; RPS23; RPS14; RPS20; RPS29; RPS27L; RPS2; RPS19
R-HSA-168255 Influenza Life Cycle 9.34 0.00e+00 0.00e+00 26/130 RPS7; RPL15; RPSA; RPL22L1; RPL9; RPL34; RPS23; RPS14; RPL10A; RPL10; RPS20; RPL7A; RPL27A; RPL41; RPS29; RPS27L; RPLP1; RPS2; RPL36; RPL18A; UBA52; RPS19; RPL18; RPL28; RPL3
R-HSA-5633008 TP53 Regulates Transcription of Cell Death Genes 9.34 7.29e-04 1.90e-02 4/20 TRIAP1; PMAIP1; BBC3; BAX
R-HSA-168254 Influenza Infection 8.73 0.00e+00 0.00e+00 26/139 RPS7; RPL15; RPSA; RPL22L1; RPL9; RPL34; RPS23; RPS14; RPL10A; RPL10; RPS20; RPL7A; RPL27A; RPL41; RPS29; RPS27L; RPLP1; RPS2; RPL36; RPL18A; UBA52; RPS19; RPL18; RPL28; RPL3
R-HSA-72649 Translation initiation complex formation 8.49 1.55e-07 4.42e-06 10/55 RPS7; RPSA; RPS23; RPS14; RPS20; RPS29; RPS27L; RPS2; RPS19
R-HSA-72702 Ribosomal scanning and start codon recognition 8.49 1.55e-07 4.42e-06 10/55 RPS7; RPSA; RPS23; RPS14; RPS20; RPS29; RPS27L; RPS2; RPS19
R-HSA-72662 Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S 8.34 1.85e-07 5.13e-06 10/56 RPS7; RPSA; RPS23; RPS14; RPS20; RPS29; RPS27L; RPS2; RPS19
R-HSA-9010553 Regulation of expression of SLITs and ROBOs 8.26 0.00e+00 0.00e+00 26/147 RPS7; RPL15; RPSA; RPL22L1; RPL9; RPL34; RPS23; RPS14; RPL10A; RPL10; RPS20; RPL7A; RPL27A; RPL41; RPS29; RPS27L; RPLP1; RPS2; RPL36; RPL18A; UBA52; RPS19; RPL18; RPL28; RPL3
R-HSA-6791226 Major pathway of rRNA processing in the nucleolus and cytosol 7.68 0.00e+00 0.00e+00 26/158 RPS7; RPL15; RPSA; RPL22L1; RPL9; RPL34; RPS23; RPS14; RPL10A; RPL10; RPS20; RPL7A; RPL27A; RPL41; RPS29; RPS27L; RPLP1; RPS2; RPL36; RPL18A; UBA52; RPS19; RPL18; RPL28; RPL3
R-HSA-376176 Signaling by ROBO receptors 7.55 0.00e+00 0.00e+00 27/167 RPS7; CXCR4; RPL15; RPSA; RPL22L1; RPL9; RPL34; RPS23; RPS14; RPL10A; RPL10; RPS20; RPL7A; RPL27A; RPL41; RPS29; RPS27L; RPLP1; RPS2; RPL36; RPL18A; UBA52; RPS19; RPL18; RPL28; RPL3
R-HSA-8868773 rRNA processing in the nucleus and cytosol 7.23 2.22e-16 8.55e-15 26/168 RPS7; RPL15; RPSA; RPL22L1; RPL9; RPL34; RPS23; RPS14; RPL10A; RPL10; RPS20; RPL7A; RPL27A; RPL41; RPS29; RPS27L; RPLP1; RPS2; RPL36; RPL18A; UBA52; RPS19; RPL18; RPL28; RPL3
R-HSA-72312 rRNA processing 6.94 4.44e-16 1.64e-14 26/175 RPS7; RPL15; RPSA; RPL22L1; RPL9; RPL34; RPS23; RPS14; RPL10A; RPL10; RPS20; RPL7A; RPL27A; RPL41; RPS29; RPS27L; RPLP1; RPS2; RPL36; RPL18A; UBA52; RPS19; RPL18; RPL28; RPL3
R-HSA-71291 Metabolism of amino acids and derivatives 5.73 4.87e-14 1.73e-12 26/212 RPS7; RPL15; RPSA; RPL22L1; RPL9; RPL34; RPS23; RPS14; RPL10A; RPL10; RPS20; RPL7A; RPL27A; RPL41; RPS29; RPS27L; RPLP1; RPS2; RPL36; RPL18A; UBA52; RPS19; RPL18; RPL28; RPL3
R-HSA-422475 Axon guidance 5.63 1.11e-16 4.47e-15 31/257 RHOC; ARPC5; RPS7; CXCR4; RPL15; RPSA; RPL22L1; RPL9; RPL34; RPS23; RPS14; RPL10A; ARPC1B; RPL10; RPS20; RPL7A; RPL27A; CFL1; RPL41; RPS29; RPS27L; RPLP1; RPS2; RPL36; RPL18A; UBA52; RPS19; RPL18; RPL28; RPL3
R-HSA-72766 Translation 4.76 1.42e-12 4.65e-11 27/265 RPS7; RPL15; RPSA; RPL22L1; RPL9; RPL34; RPS23; RPS14; RPL10A; EEF1A1; RPL10; RPS20; RPL7A; RPL27A; RPL41; RPS29; RPS27L; RPLP1; RPS2; RPL36; RPL18A; UBA52; RPS19; RPL18; RPL28; RPL3
R-HSA-5663205 Infectious disease 4.27 7.04e-12 2.23e-10 28/306 RPS7; CXCR4; RPL15; RPSA; RPL22L1; RPL9; RPL34; RPS23; RPS14; RPL10A; RPL10; RPS20; RPL7A; RPL27A; RPL41; RPS29; B2M; RPS27L; RPLP1; RPS2; RPL36; RPL18A; UBA52; RPS19; RPL18; RPL28; RPL3
R-HSA-1266738 Developmental Biology 4.09 1.10e-12 3.75e-11 31/354 RHOC; ARPC5; RPS7; CXCR4; RPL15; RPSA; RPL22L1; RPL9; RPL34; RPS23; RPS14; RPL10A; ARPC1B; RPL10; RPS20; RPL7A; RPL27A; CFL1; RPL41; RPS29; RPS27L; RPLP1; RPS2; RPL36; RPL18A; UBA52; RPS19; RPL18; RPL28; RPL3
Factor 17 : 40 significant Reactome pathways
GeneSet description enrichRatio pValue FDR GeneRatio geneSymbols
R-HSA-156902 Peptide chain elongation 17.40 0.00e+00 0.00e+00 55/85 RPL11; RPS8; RPL5; RPS27; RPS7; RPS27A; RPL31; RPL32; RPL15; RPSA; RPL29; RPL9; RPL34; RPS3A; RPL37; RPS14; RPS18; RPL10A; RPS12; RPS4X; RPL39; RPL7; RPL30; RPS6; RPL12; RPL7A; RPL27A; RPS13; RPS3; RPS25; RPS24; RPL41; RPL6; RPLP0; RPL21; RPS29; RPL4; RPLP1; RPS17; RPS2; RPL13; RPL26; RPL23; RPL19; RPS15; RPS28; RPL18A; RPS16; RPS19; RPL18; RPL13A; RPS9; RPL28; RPS5; RPL3
R-HSA-192823 Viral mRNA Translation 17.40 0.00e+00 0.00e+00 55/85 RPL11; RPS8; RPL5; RPS27; RPS7; RPS27A; RPL31; RPL32; RPL15; RPSA; RPL29; RPL9; RPL34; RPS3A; RPL37; RPS14; RPS18; RPL10A; RPS12; RPS4X; RPL39; RPL7; RPL30; RPS6; RPL12; RPL7A; RPL27A; RPS13; RPS3; RPS25; RPS24; RPL41; RPL6; RPLP0; RPL21; RPS29; RPL4; RPLP1; RPS17; RPS2; RPL13; RPL26; RPL23; RPL19; RPS15; RPS28; RPL18A; RPS16; RPS19; RPL18; RPL13A; RPS9; RPL28; RPS5; RPL3
R-HSA-2408557 Selenocysteine synthesis 17.40 0.00e+00 0.00e+00 55/85 RPL11; RPS8; RPL5; RPS27; RPS7; RPS27A; RPL31; RPL32; RPL15; RPSA; RPL29; RPL9; RPL34; RPS3A; RPL37; RPS14; RPS18; RPL10A; RPS12; RPS4X; RPL39; RPL7; RPL30; RPS6; RPL12; RPL7A; RPL27A; RPS13; RPS3; RPS25; RPS24; RPL41; RPL6; RPLP0; RPL21; RPS29; RPL4; RPLP1; RPS17; RPS2; RPL13; RPL26; RPL23; RPL19; RPS15; RPS28; RPL18A; RPS16; RPS19; RPL18; RPL13A; RPS9; RPL28; RPS5; RPL3
R-HSA-156842 Eukaryotic Translation Elongation 17.30 0.00e+00 0.00e+00 56/87 RPL11; RPS8; RPL5; RPS27; RPS7; RPS27A; RPL31; EEF1B2; RPL32; RPL15; RPSA; RPL29; RPL9; RPL34; RPS3A; RPL37; RPS14; RPS18; RPL10A; RPS12; RPS4X; RPL39; RPL7; RPL30; RPS6; RPL12; RPL7A; RPL27A; RPS13; RPS3; RPS25; RPS24; RPL41; RPL6; RPLP0; RPL21; RPS29; RPL4; RPLP1; RPS17; RPS2; RPL13; RPL26; RPL23; RPL19; RPS15; RPS28; RPL18A; RPS16; RPS19; RPL18; RPL13A; RPS9; RPL28; RPS5; RPL3
R-HSA-72764 Eukaryotic Translation Termination 16.80 0.00e+00 0.00e+00 55/88 RPL11; RPS8; RPL5; RPS27; RPS7; RPS27A; RPL31; RPL32; RPL15; RPSA; RPL29; RPL9; RPL34; RPS3A; RPL37; RPS14; RPS18; RPL10A; RPS12; RPS4X; RPL39; RPL7; RPL30; RPS6; RPL12; RPL7A; RPL27A; RPS13; RPS3; RPS25; RPS24; RPL41; RPL6; RPLP0; RPL21; RPS29; RPL4; RPLP1; RPS17; RPS2; RPL13; RPL26; RPL23; RPL19; RPS15; RPS28; RPL18A; RPS16; RPS19; RPL18; RPL13A; RPS9; RPL28; RPS5; RPL3
R-HSA-975956 Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) 16.60 0.00e+00 0.00e+00 55/89 RPL11; RPS8; RPL5; RPS27; RPS7; RPS27A; RPL31; RPL32; RPL15; RPSA; RPL29; RPL9; RPL34; RPS3A; RPL37; RPS14; RPS18; RPL10A; RPS12; RPS4X; RPL39; RPL7; RPL30; RPS6; RPL12; RPL7A; RPL27A; RPS13; RPS3; RPS25; RPS24; RPL41; RPL6; RPLP0; RPL21; RPS29; RPL4; RPLP1; RPS17; RPS2; RPL13; RPL26; RPL23; RPL19; RPS15; RPS28; RPL18A; RPS16; RPS19; RPL18; RPL13A; RPS9; RPL28; RPS5; RPL3
R-HSA-72689 Formation of a pool of free 40S subunits 15.40 0.00e+00 0.00e+00 55/96 RPL11; RPS8; RPL5; RPS27; RPS7; RPS27A; RPL31; RPL32; RPL15; RPSA; RPL29; RPL9; RPL34; RPS3A; RPL37; RPS14; RPS18; RPL10A; RPS12; RPS4X; RPL39; RPL7; RPL30; RPS6; RPL12; RPL7A; RPL27A; RPS13; RPS3; RPS25; RPS24; RPL41; RPL6; RPLP0; RPL21; RPS29; RPL4; RPLP1; RPS17; RPS2; RPL13; RPL26; RPL23; RPL19; RPS15; RPS28; RPL18A; RPS16; RPS19; RPL18; RPL13A; RPS9; RPL28; RPS5; RPL3
R-HSA-2408522 Selenoamino acid metabolism 15.20 0.00e+00 0.00e+00 56/99 RPL11; RPS8; RPL5; RPS27; RPS7; RPS27A; RPL31; DARS; RPL32; RPL15; RPSA; RPL29; RPL9; RPL34; RPS3A; RPL37; RPS14; RPS18; RPL10A; RPS12; RPS4X; RPL39; RPL7; RPL30; RPS6; RPL12; RPL7A; RPL27A; RPS13; RPS3; RPS25; RPS24; RPL41; RPL6; RPLP0; RPL21; RPS29; RPL4; RPLP1; RPS17; RPS2; RPL13; RPL26; RPL23; RPL19; RPS15; RPS28; RPL18A; RPS16; RPS19; RPL18; RPL13A; RPS9; RPL28; RPS5; RPL3
R-HSA-70263 Gluconeogenesis 14.20 2.04e-09 5.47e-08 9/17 ENO1; PGK1; PGAM1; GAPDH; TPI1; ENO2; ALDOA; ALDOC; GPI
R-HSA-1799339 SRP-dependent cotranslational protein targeting to membrane 14.00 0.00e+00 0.00e+00 56/107 RPL11; RPS8; RPL5; RPS27; RPS7; RPS27A; RPL31; RPL32; RPL15; RPSA; RPL29; RPL9; RPL34; RPS3A; RPL37; RPS14; RPS18; RPL10A; RPS12; SEC61G; RPS4X; RPL39; RPL7; RPL30; RPS6; RPL12; RPL7A; RPL27A; RPS13; RPS3; RPS25; RPS24; RPL41; RPL6; RPLP0; RPL21; RPS29; RPL4; RPLP1; RPS17; RPS2; RPL13; RPL26; RPL23; RPL19; RPS15; RPS28; RPL18A; RPS16; RPS19; RPL18; RPL13A; RPS9; RPL28; RPS5; RPL3
R-HSA-156827 L13a-mediated translational silencing of Ceruloplasmin expression 13.90 0.00e+00 0.00e+00 55/106 RPL11; RPS8; RPL5; RPS27; RPS7; RPS27A; RPL31; RPL32; RPL15; RPSA; RPL29; RPL9; RPL34; RPS3A; RPL37; RPS14; RPS18; RPL10A; RPS12; RPS4X; RPL39; RPL7; RPL30; RPS6; RPL12; RPL7A; RPL27A; RPS13; RPS3; RPS25; RPS24; RPL41; RPL6; RPLP0; RPL21; RPS29; RPL4; RPLP1; RPS17; RPS2; RPL13; RPL26; RPL23; RPL19; RPS15; RPS28; RPL18A; RPS16; RPS19; RPL18; RPL13A; RPS9; RPL28; RPS5; RPL3
R-HSA-927802 Nonsense-Mediated Decay (NMD) 13.90 0.00e+00 0.00e+00 55/106 RPL11; RPS8; RPL5; RPS27; RPS7; RPS27A; RPL31; RPL32; RPL15; RPSA; RPL29; RPL9; RPL34; RPS3A; RPL37; RPS14; RPS18; RPL10A; RPS12; RPS4X; RPL39; RPL7; RPL30; RPS6; RPL12; RPL7A; RPL27A; RPS13; RPS3; RPS25; RPS24; RPL41; RPL6; RPLP0; RPL21; RPS29; RPL4; RPLP1; RPS17; RPS2; RPL13; RPL26; RPL23; RPL19; RPS15; RPS28; RPL18A; RPS16; RPS19; RPL18; RPL13A; RPS9; RPL28; RPS5; RPL3
R-HSA-975957 Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) 13.90 0.00e+00 0.00e+00 55/106 RPL11; RPS8; RPL5; RPS27; RPS7; RPS27A; RPL31; RPL32; RPL15; RPSA; RPL29; RPL9; RPL34; RPS3A; RPL37; RPS14; RPS18; RPL10A; RPS12; RPS4X; RPL39; RPL7; RPL30; RPS6; RPL12; RPL7A; RPL27A; RPS13; RPS3; RPS25; RPS24; RPL41; RPL6; RPLP0; RPL21; RPS29; RPL4; RPLP1; RPS17; RPS2; RPL13; RPL26; RPL23; RPL19; RPS15; RPS28; RPL18A; RPS16; RPS19; RPL18; RPL13A; RPS9; RPL28; RPS5; RPL3
R-HSA-72706 GTP hydrolysis and joining of the 60S ribosomal subunit 13.80 0.00e+00 0.00e+00 55/107 RPL11; RPS8; RPL5; RPS27; RPS7; RPS27A; RPL31; RPL32; RPL15; RPSA; RPL29; RPL9; RPL34; RPS3A; RPL37; RPS14; RPS18; RPL10A; RPS12; RPS4X; RPL39; RPL7; RPL30; RPS6; RPL12; RPL7A; RPL27A; RPS13; RPS3; RPS25; RPS24; RPL41; RPL6; RPLP0; RPL21; RPS29; RPL4; RPLP1; RPS17; RPS2; RPL13; RPL26; RPL23; RPL19; RPS15; RPS28; RPL18A; RPS16; RPS19; RPL18; RPL13A; RPS9; RPL28; RPS5; RPL3
R-HSA-72695 Formation of the ternary complex, and subsequently, the 43S complex 13.40 0.00e+00 0.00e+00 24/48 RPS8; RPS27; RPS7; RPS27A; RPSA; RPS3A; RPS14; RPS18; RPS12; RPS4X; RPS6; RPS13; RPS3; RPS25; RPS24; RPS29; RPS17; RPS2; RPS15; RPS28; RPS16; RPS19; RPS9; RPS5
R-HSA-72613 Eukaryotic Translation Initiation 12.90 0.00e+00 0.00e+00 55/114 RPL11; RPS8; RPL5; RPS27; RPS7; RPS27A; RPL31; RPL32; RPL15; RPSA; RPL29; RPL9; RPL34; RPS3A; RPL37; RPS14; RPS18; RPL10A; RPS12; RPS4X; RPL39; RPL7; RPL30; RPS6; RPL12; RPL7A; RPL27A; RPS13; RPS3; RPS25; RPS24; RPL41; RPL6; RPLP0; RPL21; RPS29; RPL4; RPLP1; RPS17; RPS2; RPL13; RPL26; RPL23; RPL19; RPS15; RPS28; RPL18A; RPS16; RPS19; RPL18; RPL13A; RPS9; RPL28; RPS5; RPL3
R-HSA-72737 Cap-dependent Translation Initiation 12.90 0.00e+00 0.00e+00 55/114 RPL11; RPS8; RPL5; RPS27; RPS7; RPS27A; RPL31; RPL32; RPL15; RPSA; RPL29; RPL9; RPL34; RPS3A; RPL37; RPS14; RPS18; RPL10A; RPS12; RPS4X; RPL39; RPL7; RPL30; RPS6; RPL12; RPL7A; RPL27A; RPS13; RPS3; RPS25; RPS24; RPL41; RPL6; RPLP0; RPL21; RPS29; RPL4; RPLP1; RPS17; RPS2; RPL13; RPL26; RPL23; RPL19; RPS15; RPS28; RPL18A; RPS16; RPS19; RPL18; RPL13A; RPS9; RPL28; RPS5; RPL3
R-HSA-168273 Influenza Viral RNA Transcription and Replication 12.40 0.00e+00 0.00e+00 56/121 RPL11; RPS8; RPL5; RPS27; RPS7; RPS27A; RPL31; RPL32; RPL15; RPSA; RPL29; POLR2H; RPL9; RPL34; RPS3A; RPL37; RPS14; RPS18; RPL10A; RPS12; RPS4X; RPL39; RPL7; RPL30; RPS6; RPL12; RPL7A; RPL27A; RPS13; RPS3; RPS25; RPS24; RPL41; RPL6; RPLP0; RPL21; RPS29; RPL4; RPLP1; RPS17; RPS2; RPL13; RPL26; RPL23; RPL19; RPS15; RPS28; RPL18A; RPS16; RPS19; RPL18; RPL13A; RPS9; RPL28; RPS5; RPL3
R-HSA-72649 Translation initiation complex formation 11.70 0.00e+00 0.00e+00 24/55 RPS8; RPS27; RPS7; RPS27A; RPSA; RPS3A; RPS14; RPS18; RPS12; RPS4X; RPS6; RPS13; RPS3; RPS25; RPS24; RPS29; RPS17; RPS2; RPS15; RPS28; RPS16; RPS19; RPS9; RPS5
R-HSA-72702 Ribosomal scanning and start codon recognition 11.70 0.00e+00 0.00e+00 24/55 RPS8; RPS27; RPS7; RPS27A; RPSA; RPS3A; RPS14; RPS18; RPS12; RPS4X; RPS6; RPS13; RPS3; RPS25; RPS24; RPS29; RPS17; RPS2; RPS15; RPS28; RPS16; RPS19; RPS9; RPS5
R-HSA-168255 Influenza Life Cycle 11.60 0.00e+00 0.00e+00 56/130 RPL11; RPS8; RPL5; RPS27; RPS7; RPS27A; RPL31; RPL32; RPL15; RPSA; RPL29; POLR2H; RPL9; RPL34; RPS3A; RPL37; RPS14; RPS18; RPL10A; RPS12; RPS4X; RPL39; RPL7; RPL30; RPS6; RPL12; RPL7A; RPL27A; RPS13; RPS3; RPS25; RPS24; RPL41; RPL6; RPLP0; RPL21; RPS29; RPL4; RPLP1; RPS17; RPS2; RPL13; RPL26; RPL23; RPL19; RPS15; RPS28; RPL18A; RPS16; RPS19; RPL18; RPL13A; RPS9; RPL28; RPS5; RPL3
R-HSA-72662 Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S 11.50 0.00e+00 0.00e+00 24/56 RPS8; RPS27; RPS7; RPS27A; RPSA; RPS3A; RPS14; RPS18; RPS12; RPS4X; RPS6; RPS13; RPS3; RPS25; RPS24; RPS29; RPS17; RPS2; RPS15; RPS28; RPS16; RPS19; RPS9; RPS5
R-HSA-168254 Influenza Infection 10.80 0.00e+00 0.00e+00 56/139 RPL11; RPS8; RPL5; RPS27; RPS7; RPS27A; RPL31; RPL32; RPL15; RPSA; RPL29; POLR2H; RPL9; RPL34; RPS3A; RPL37; RPS14; RPS18; RPL10A; RPS12; RPS4X; RPL39; RPL7; RPL30; RPS6; RPL12; RPL7A; RPL27A; RPS13; RPS3; RPS25; RPS24; RPL41; RPL6; RPLP0; RPL21; RPS29; RPL4; RPLP1; RPS17; RPS2; RPL13; RPL26; RPL23; RPL19; RPS15; RPS28; RPL18A; RPS16; RPS19; RPL18; RPL13A; RPS9; RPL28; RPS5; RPL3
R-HSA-9010553 Regulation of expression of SLITs and ROBOs 10.20 0.00e+00 0.00e+00 56/147 RPL11; RPS8; RPL5; RPS27; RPS7; RPS27A; RPL31; RPL32; RPL15; RPSA; RPL29; RPL9; RPL34; RPS3A; RPL37; RPS14; RPS18; RPL10A; RPS12; RPS4X; RPL39; RPL7; RPL30; RPS6; RPL12; RPL7A; RPL27A; RPS13; RPS3; RPS25; RPS24; RPL41; RPL6; RPLP0; RPL21; RPS29; RPL4; RPLP1; RPS17; RPS2; TCEB2; RPL13; RPL26; RPL23; RPL19; RPS15; RPS28; RPL18A; RPS16; RPS19; RPL18; RPL13A; RPS9; RPL28; RPS5; RPL3
R-HSA-191273 Cholesterol biosynthesis 9.39 4.45e-06 1.10e-04 7/20 FDPS; HMGCS1; ACAT2; EBP; FDFT1; SQLE; DHCR7
R-HSA-6791226 Major pathway of rRNA processing in the nucleolus and cytosol 9.34 0.00e+00 0.00e+00 55/158 RPL11; RPS8; RPL5; RPS27; RPS7; RPS27A; RPL31; RPL32; RPL15; RPSA; RPL29; RPL9; RPL34; RPS3A; RPL37; RPS14; RPS18; RPL10A; RPS12; RPS4X; RPL39; RPL7; RPL30; RPS6; RPL12; RPL7A; RPL27A; RPS13; RPS3; RPS25; RPS24; RPL41; RPL6; RPLP0; RPL21; RPS29; RPL4; RPLP1; RPS17; RPS2; RPL13; RPL26; RPL23; RPL19; RPS15; RPS28; RPL18A; RPS16; RPS19; RPL18; RPL13A; RPS9; RPL28; RPS5; RPL3
R-HSA-376176 Signaling by ROBO receptors 8.99 0.00e+00 0.00e+00 56/167 RPL11; RPS8; RPL5; RPS27; RPS7; RPS27A; RPL31; RPL32; RPL15; RPSA; RPL29; RPL9; RPL34; RPS3A; RPL37; RPS14; RPS18; RPL10A; RPS12; RPS4X; RPL39; RPL7; RPL30; RPS6; RPL12; RPL7A; RPL27A; RPS13; RPS3; RPS25; RPS24; RPL41; RPL6; RPLP0; RPL21; RPS29; RPL4; RPLP1; RPS17; RPS2; TCEB2; RPL13; RPL26; RPL23; RPL19; RPS15; RPS28; RPL18A; RPS16; RPS19; RPL18; RPL13A; RPS9; RPL28; RPS5; RPL3
R-HSA-8868773 rRNA processing in the nucleus and cytosol 8.78 0.00e+00 0.00e+00 55/168 RPL11; RPS8; RPL5; RPS27; RPS7; RPS27A; RPL31; RPL32; RPL15; RPSA; RPL29; RPL9; RPL34; RPS3A; RPL37; RPS14; RPS18; RPL10A; RPS12; RPS4X; RPL39; RPL7; RPL30; RPS6; RPL12; RPL7A; RPL27A; RPS13; RPS3; RPS25; RPS24; RPL41; RPL6; RPLP0; RPL21; RPS29; RPL4; RPLP1; RPS17; RPS2; RPL13; RPL26; RPL23; RPL19; RPS15; RPS28; RPL18A; RPS16; RPS19; RPL18; RPL13A; RPS9; RPL28; RPS5; RPL3
R-HSA-72312 rRNA processing 8.43 0.00e+00 0.00e+00 55/175 RPL11; RPS8; RPL5; RPS27; RPS7; RPS27A; RPL31; RPL32; RPL15; RPSA; RPL29; RPL9; RPL34; RPS3A; RPL37; RPS14; RPS18; RPL10A; RPS12; RPS4X; RPL39; RPL7; RPL30; RPS6; RPL12; RPL7A; RPL27A; RPS13; RPS3; RPS25; RPS24; RPL41; RPL6; RPLP0; RPL21; RPS29; RPL4; RPLP1; RPS17; RPS2; RPL13; RPL26; RPL23; RPL19; RPS15; RPS28; RPL18A; RPS16; RPS19; RPL18; RPL13A; RPS9; RPL28; RPS5; RPL3
R-HSA-71291 Metabolism of amino acids and derivatives 7.59 0.00e+00 0.00e+00 60/212 RPL11; RPS8; RPL5; RPS27; RPS7; RPS27A; RPL31; DARS; RPL32; RPL15; RPSA; RPL29; RPL9; RPL34; RPS3A; RPL37; RPS14; RPS18; RPL10A; RPS12; RPS4X; RPL39; RPL7; RPL30; RPS6; RPL12; RPL7A; RPL27A; RPS13; RPS3; RPS25; RPS24; BCAT1; RPL41; RPL6; RPLP0; RPL21; RPS29; SQRDL; RPL4; RPLP1; RPS17; RPS2; BCKDK; RPL13; RPL26; RPL23; RPL19; RPS15; OAZ1; RPS28; RPL18A; RPS16; RPS19; RPL18; RPL13A; RPS9; RPL28; RPS5; RPL3
R-HSA-70171 Glycolysis 7.38 1.20e-07 3.12e-06 11/40 ENO1; PGK1; PFKP; PGAM1; GAPDH; TPI1; ENO2; PKM; ALDOA; ALDOC; GPI
R-HSA-1655829 Regulation of cholesterol biosynthesis by SREBP (SREBF) 7.15 8.94e-06 2.14e-04 8/30 FDPS; INSIG2; HMGCS1; INSIG1; FDFT1; SQLE; DHCR7; SCD
R-HSA-2426168 Activation of gene expression by SREBF (SREBP) 6.71 1.86e-04 4.13e-03 6/24 FDPS; HMGCS1; FDFT1; SQLE; DHCR7; SCD
R-HSA-70326 Glucose metabolism 6.15 9.06e-07 2.29e-05 11/48 ENO1; PGK1; PFKP; PGAM1; GAPDH; TPI1; ENO2; PKM; ALDOA; ALDOC; GPI
R-HSA-422475 Axon guidance 6.05 0.00e+00 0.00e+00 58/257 RPL11; RPS8; RPL5; RPS27; RPS7; RPS27A; RPL31; RPL32; RPL15; RPSA; RPL29; RPL9; RPL34; RPS3A; RPL37; RPS14; RPS18; RPL10A; HSP90AB1; RPS12; ACTB; RPS4X; RPL39; RPL7; RPL30; RPS6; RPL12; RPL7A; RPL27A; RPS13; RPS3; RPS25; RPS24; RPL41; RPL6; RPLP0; RPL21; RPS29; RPL4; RPLP1; RPS17; RPS2; TCEB2; RPL13; RPL26; RPL23; RPL19; RPS15; RPS28; RPL18A; RPS16; RPS19; RPL18; RPL13A; RPS9; RPL28; RPS5; RPL3
R-HSA-72766 Translation 5.87 0.00e+00 0.00e+00 58/265 RPL11; RPS8; RPL5; RPS27; RPS7; RPS27A; RPL31; DARS; EEF1B2; RPL32; RPL15; RPSA; RPL29; RPL9; RPL34; RPS3A; RPL37; RPS14; RPS18; RPL10A; RPS12; SEC61G; RPS4X; RPL39; RPL7; RPL30; RPS6; RPL12; RPL7A; RPL27A; RPS13; RPS3; RPS25; RPS24; RPL41; RPL6; RPLP0; RPL21; RPS29; RPL4; RPLP1; RPS17; RPS2; RPL13; RPL26; RPL23; RPL19; RPS15; RPS28; RPL18A; RPS16; RPS19; RPL18; RPL13A; RPS9; RPL28; RPS5; RPL3
R-HSA-5663205 Infectious disease 5.08 0.00e+00 0.00e+00 58/306 RPL11; RPS8; RPL5; RPS27; RPS7; RPS27A; RPL31; RPL32; RPL15; RPSA; RPL29; POLR2H; RPL9; RPL34; RPS3A; RPL37; RPS14; RPS18; RPL10A; HSP90AB1; RPS12; RPS4X; RPL39; RPL7; RPL30; RPS6; RPL12; RPL7A; RPL27A; RPS13; RPS3; RPS25; RPS24; RPL41; RPL6; RPLP0; RPL21; RPS29; RPL4; RPLP1; RPS17; RPS2; TCEB2; RPL13; RPL26; RPL23; RPL19; RPS15; RPS28; RPL18A; RPS16; RPS19; RPL18; RPL13A; RPS9; RPL28; RPS5; RPL3
R-HSA-8957322 Metabolism of steroids 4.79 3.09e-05 7.20e-04 10/56 FDPS; INSIG2; HMGCS1; ACAT2; INSIG1; EBP; FDFT1; SQLE; DHCR7; SCD
R-HSA-1266738 Developmental Biology 4.47 0.00e+00 0.00e+00 59/354 RPL11; RPS8; RPL5; RPS27; RPS7; RPS27A; RPL31; RPL32; RPL15; RPSA; RPL29; POLR2H; RPL9; RPL34; RPS3A; RPL37; RPS14; RPS18; RPL10A; HSP90AB1; RPS12; ACTB; RPS4X; RPL39; RPL7; RPL30; RPS6; RPL12; RPL7A; RPL27A; RPS13; RPS3; RPS25; RPS24; RPL41; RPL6; RPLP0; RPL21; RPS29; RPL4; RPLP1; RPS17; RPS2; TCEB2; RPL13; RPL26; RPL23; RPL19; RPS15; RPS28; RPL18A; RPS16; RPS19; RPL18; RPL13A; RPS9; RPL28; RPS5; RPL3
R-HSA-71387 Metabolism of carbohydrates 3.49 6.75e-05 1.53e-03 13/100 ENO1; PGM1; RPS27A; PGK1; PFKP; PGAM1; GAPDH; TPI1; ENO2; PKM; ALDOA; ALDOC; GPI
Factor 18 : 39 significant Reactome pathways
GeneSet description enrichRatio pValue FDR GeneRatio geneSymbols
R-HSA-202430 Translocation of ZAP-70 to Immunological synapse 15.60 8.23e-08 7.29e-06 7/14 HLA-DRA; HLA-DRB5; HLA-DRB1; HLA-DQA1; HLA-DQB1; HLA-DPA1; HLA-DPB1
R-HSA-375276 Peptide ligand-binding receptors 14.60 1.50e-07 1.11e-05 7/15 XCL2; XCL1; CXCR4; CXCL10; CXCR3; CCL1; CCR7
R-HSA-389948 PD-1 signaling 14.60 1.50e-07 1.11e-05 7/15 HLA-DRA; HLA-DRB5; HLA-DRB1; HLA-DQA1; HLA-DQB1; HLA-DPA1; HLA-DPB1
R-HSA-202427 Phosphorylation of CD3 and TCR zeta chains 13.70 2.60e-07 1.77e-05 7/16 HLA-DRA; HLA-DRB5; HLA-DRB1; HLA-DQA1; HLA-DQB1; HLA-DPA1; HLA-DPB1
R-HSA-6783783 Interleukin-10 signaling 12.50 3.75e-06 1.84e-04 6/15 CXCL10; TIMP1; CCL3; CCL4; CCL3L3
R-HSA-202433 Generation of second messenger molecules 11.70 2.28e-08 2.88e-06 9/24 HLA-DRA; HLA-DRB5; HLA-DRB1; HLA-DQA1; HLA-DQB1; HLA-DPA1; HLA-DPB1; EVL; VASP
R-HSA-983170 Antigen Presentation: Folding, assembly and peptide loading of class I MHC 11.50 1.06e-06 6.24e-05 7/19 HLA-F; HLA-A; HLA-E; HLA-C; HLA-B; TAP1; B2M
R-HSA-446353 Cell-extracellular matrix interactions 11.40 2.76e-04 1.06e-02 4/11 ITGB1; ACTN1; ACTG1; VASP
R-HSA-877300 Interferon gamma signaling 10.90 1.97e-13 1.74e-10 16/46 STAT1; IRF1; IRF4; HLA-F; HLA-A; HLA-E; HLA-C; HLA-B; HLA-DRA; HLA-DRB5; HLA-DRB1; HLA-DQA1; HLA-DQB1; HLA-DPA1; HLA-DPB1; B2M
R-HSA-373076 Class A/1 (Rhodopsin-like receptors) 10.40 7.53e-08 7.29e-06 9/27 XCL2; XCL1; CXCR4; CXCL10; PTGER4; CXCR3; CCL1; CCR7; PTGIR
R-HSA-198933 Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell 9.05 1.32e-08 2.53e-06 11/38 SELL; CD8A; HLA-F; HLA-A; HLA-E; HLA-C; HLA-B; ITGB1; ITGB7; B2M; HCST
R-HSA-446728 Cell junction organization 8.93 7.78e-04 2.03e-02 4/14 ITGB1; ACTN1; ACTG1; VASP
R-HSA-1489509 DAG and IP3 signaling 8.93 7.78e-04 2.03e-02 4/14 ITPR1; PRKAR1B; CALM1
R-HSA-216083 Integrin cell surface interactions 8.93 7.78e-04 2.03e-02 4/14 ITGA1; ITGB1; ITGB7; PECAM1
R-HSA-418360 Platelet calcium homeostasis 8.93 7.78e-04 2.03e-02 4/14 ITPR1; ATP2B1; CALM1
R-HSA-909733 Interferon alpha/beta signaling 8.79 3.93e-07 2.49e-05 9/32 STAT1; IRF1; IRF4; HLA-F; HLA-A; HLA-E; HLA-C; HLA-B; IFITM2
R-HSA-500792 GPCR ligand binding 7.60 1.52e-06 7.95e-05 9/37 XCL2; XCL1; CXCR4; CXCL10; PTGER4; CXCR3; CCL1; CCR7; PTGIR
R-HSA-112040 G-protein mediated events 7.35 1.72e-03 4.00e-02 4/17 ITPR1; PRKAR1B; CALM1
R-HSA-112043 PLC beta mediated events 7.35 1.72e-03 4.00e-02 4/17 ITPR1; PRKAR1B; CALM1
R-HSA-5578775 Ion homeostasis 6.95 2.15e-03 4.89e-02 4/18 ITPR1; ATP2B1; CALM1
R-HSA-418594 G alpha (i) signalling events 6.44 1.59e-08 2.53e-06 14/68 DHRS3; RGS1; CXCR4; ITPR1; CXCL10; GPSM3; PRKAR1B; CXCR3; RGS10; CALM1; CCL1; CCL4; CCR7
R-HSA-418346 Platelet homeostasis 5.86 4.34e-04 1.36e-02 6/32 ITPR1; ATP2B1; CALM1; PECAM1; PTGIR
R-HSA-388841 Costimulation by the CD28 family 5.21 3.07e-04 1.09e-02 7/42 HLA-DRA; HLA-DRB5; HLA-DRB1; HLA-DQA1; HLA-DQB1; HLA-DPA1; HLA-DPB1
R-HSA-202733 Cell surface interactions at the vascular wall 5.21 3.07e-04 1.09e-02 7/42 SELL; GYPC; CD74; DOK2; ITGB1; PECAM1; SIRPG
R-HSA-913531 Interferon Signaling 4.97 2.60e-08 2.88e-06 17/107 STAT1; IRF1; IRF4; HLA-F; HLA-A; HLA-E; HLA-C; HLA-B; HLA-DRA; HLA-DRB5; HLA-DRB1; HLA-DQA1; HLA-DQB1; HLA-DPA1; HLA-DPB1; IFITM2; B2M
R-HSA-1474244 Extracellular matrix organization 4.94 1.13e-03 2.86e-02 6/38 ITGA1; TIMP1; ITGB1; ITGB7; ACTN1; PECAM1
R-HSA-388396 GPCR downstream signalling 4.60 1.32e-08 2.53e-06 19/129 DHRS3; RHOC; XCL2; XCL1; RGS1; CXCR4; ITPR1; CXCL10; PTGER4; GPSM3; PRKAR1B; CXCR3; RGS10; CALM1; CCL1; CCL4; CCR7; PTGIR
R-HSA-114608 Platelet degranulation 4.56 7.14e-04 2.03e-02 7/48 TIMP1; CTSW; CD63; ACTN1; CALM1; PECAM1
R-HSA-372790 Signaling by GPCR 4.53 1.71e-08 2.53e-06 19/131 DHRS3; RHOC; XCL2; XCL1; RGS1; CXCR4; ITPR1; CXCL10; PTGER4; GPSM3; PRKAR1B; CXCR3; RGS10; CALM1; CCL1; CCL4; CCR7; PTGIR
R-HSA-76005 Response to elevated platelet cytosolic Ca2+ 4.21 1.17e-03 2.87e-02 7/52 TIMP1; CTSW; CD63; ACTN1; CALM1; PECAM1
R-HSA-1236974 ER-Phagosome pathway 4.14 2.62e-04 1.05e-02 9/68 HLA-F; HLA-A; HLA-E; HLA-C; HLA-B; PSMB9; TAP1; PSME1; B2M
R-HSA-202424 Downstream TCR signaling 3.96 1.72e-04 7.27e-03 10/79 HLA-DRA; HLA-DRB5; HLA-DRB1; HLA-DQA1; HLA-DQB1; PSMB9; HLA-DPA1; HLA-DPB1; PSME1; NFKBIA
R-HSA-202403 TCR signaling 3.95 3.83e-05 1.70e-03 12/95 HLA-DRA; HLA-DRB5; HLA-DRB1; HLA-DQA1; HLA-DQB1; PSMB9; HLA-DPA1; HLA-DPB1; PSME1; NFKBIA; EVL; VASP
R-HSA-2132295 MHC class II antigen presentation 3.91 4.06e-04 1.33e-02 9/72 CD74; HLA-DRA; HLA-DRB5; HLA-DRB1; HLA-DQA1; HLA-DQB1; HLA-DMB; HLA-DPA1; HLA-DPB1
R-HSA-1236975 Antigen processing-Cross presentation 3.91 4.06e-04 1.33e-02 9/72 HLA-F; HLA-A; HLA-E; HLA-C; HLA-B; PSMB9; TAP1; PSME1; B2M
R-HSA-1280215 Cytokine Signaling in Immune system 3.26 1.63e-10 7.24e-08 34/326 PTPN7; STAT1; CXCL10; IRF1; IRF4; HLA-F; HLA-A; HLA-E; HLA-C; HLA-B; HLA-DRA; HLA-DRB5; HLA-DRB1; HLA-DQA1; HLA-DQB1; PSMB9; HLA-DPA1; HLA-DPB1; FSCN1; TIMP1; DUSP4; IFITM2; BIRC3; ITGB1; PSME1; NFKBIA; B2M; IL16; LGALS9; CCL3; CCL4; CCL3L3; CD70
R-HSA-109582 Hemostasis 2.92 1.01e-05 4.70e-04 20/214 SELL; GYPC; ITPR1; ITGA1; IRF1; CD74; PRKAR1B; TIMP1; DOK2; CTSW; ITGB1; CD63; ATP2B1; ACTN1; CALM1; PECAM1; SIRPG; PTGIR; RAC2
R-HSA-449147 Signaling by Interleukins 2.45 4.45e-04 1.36e-02 17/217 PTPN7; STAT1; CXCL10; IRF4; PSMB9; FSCN1; TIMP1; DUSP4; ITGB1; PSME1; NFKBIA; IL16; LGALS9; CCL3; CCL4; CCL3L3
R-HSA-1280218 Adaptive Immune System 2.44 1.26e-06 6.98e-05 31/397 SELL; REL; CD8A; ITPR1; CD74; HLA-F; HLA-A; HLA-E; HLA-C; HLA-B; HLA-DRA; HLA-DRB5; HLA-DRB1; HLA-DQA1; HLA-DQB1; PSMB9; TAP1; HLA-DMB; HLA-DPA1; HLA-DPB1; ITGB1; ITGB7; PSME1; NFKBIA; CALM1; EVL; B2M; HCST; CD79A; VASP
Factor 19 : 19 significant Reactome pathways
GeneSet description enrichRatio pValue FDR GeneRatio geneSymbols
R-HSA-6783783 Interleukin-10 signaling 17.40 1.29e-11 1.63e-09 10/15 TNFRSF1B; CXCL10; CSF2; TIMP1; CCL5; CCL3; CCL4; CCL3L3; CCL4L2
R-HSA-373076 Class A/1 (Rhodopsin-like receptors) 14.50 3.22e-15 2.85e-12 15/27 XCL2; XCL1; CXCL10; PTGER4; F2R; HRH2; CXCR3; ANXA1; GPR183; PTGER2; GPR65; CCL5; CCR7; S1PR4; PTGIR
R-HSA-375276 Peptide ligand-binding receptors 13.90 1.98e-08 1.75e-06 8/15 XCL2; XCL1; CXCL10; F2R; CXCR3; ANXA1; CCL5; CCR7
R-HSA-5669034 TNFs bind their physiological receptors 13.00 1.67e-05 9.86e-04 5/10 TNFRSF18; TNFRSF4; TNFRSF9; TNFRSF1B; CD27
R-HSA-500792 GPCR ligand binding 11.30 6.16e-14 2.73e-11 16/37 XCL2; XCL1; RAMP1; CXCL10; PTGER4; F2R; HRH2; CXCR3; ANXA1; GPR183; PTGER2; GPR65; CCL5; CCR7; S1PR4; PTGIR
R-HSA-6785807 Interleukin-4 and Interleukin-13 signaling 8.24 7.36e-09 8.15e-07 12/38 TNFRSF1B; MCL1; IRF4; FSCN1; TIMP1; ANXA1; GATA3; VIM; ITGB1; HIF1A; BCL2; OSM
R-HSA-445355 Smooth Muscle Contraction 7.25 4.42e-04 2.06e-02 5/18 ANXA1; MYL6; CALM1; ANXA2
R-HSA-198933 Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell 6.18 8.80e-06 5.96e-04 9/38 CD8A; CD8B; ITGA4; CD96; CD3D; CRTAM; ITGB1; KLRD1; HCST
R-HSA-114608 Platelet degranulation 5.43 9.42e-06 5.96e-04 10/48 TAGLN2; FAM3C; TIMP1; FLNA; CTSW; CD9; CALM1; PECAM1; SOD1
R-HSA-388396 GPCR downstream signalling 5.05 5.51e-12 1.22e-09 25/129 XCL2; XCL1; RAMP1; CXCL10; PTGER4; F2R; HRH2; CXCR3; ANXA1; RGS3; RGS10; GPR183; PTGER2; PRKCH; GPR65; CALM1; CCL5; CCL4; CCL4L2; CCR7; GNA15; S1PR4; PTGIR
R-HSA-76005 Response to elevated platelet cytosolic Ca2+ 5.02 2.00e-05 1.11e-03 10/52 TAGLN2; FAM3C; TIMP1; FLNA; CTSW; CD9; CALM1; PECAM1; SOD1
R-HSA-418594 G alpha (i) signalling events 4.99 1.15e-06 9.27e-05 13/68 CXCL10; CXCR3; ANXA1; RGS10; GPR183; CALM1; CCL5; CCL4; CCL4L2; CCR7; S1PR4
R-HSA-372790 Signaling by GPCR 4.98 7.91e-12 1.40e-09 25/131 XCL2; XCL1; RAMP1; CXCL10; PTGER4; F2R; HRH2; CXCR3; ANXA1; RGS3; RGS10; GPR183; PTGER2; PRKCH; GPR65; CALM1; CCL5; CCL4; CCL4L2; CCR7; GNA15; S1PR4; PTGIR
R-HSA-202733 Cell surface interactions at the vascular wall 4.97 1.50e-04 7.82e-03 8/42 CD58; CD2; ITGA4; CD44; ITGB1; PTPN6; PECAM1; SIRPG
R-HSA-416476 G alpha (q) signalling events 4.74 2.11e-04 1.04e-02 8/44 XCL2; XCL1; F2R; ANXA1; RGS3; PRKCH; GPR65; GNA15
R-HSA-76002 Platelet activation, signaling and aggregation 4.01 1.39e-06 1.03e-04 16/104 RAP1A; TAGLN2; F2R; LCP2; FAM3C; TIMP1; FLNA; CTSW; CD9; PTPN6; PRKCH; CALM1; PECAM1; GNA15; SOD1
R-HSA-449147 Signaling by Interleukins 3.85 9.88e-12 1.46e-09 32/217 TNFRSF1B; MCL1; PTPN7; CXCL10; IL7R; CSF2; HAVCR2; IRF4; FSCN1; TIMP1; DUSP4; ANXA1; IL2RA; GATA3; VIM; ITGB1; PTPN6; IFNG; DUSP6; HMGB1; HIF1A; ANXA2; IL16; CCL5; CCL3; CCL4; CCL3L3; CCL4L2; BCL2; OSM; SOD1
R-HSA-1280215 Cytokine Signaling in Immune system 3.36 2.93e-13 8.66e-11 42/326 TNFRSF18; TNFRSF4; TNFRSF9; TNFRSF1B; GBP2; GBP5; MCL1; PTPN7; CXCL10; IL7R; CSF2; HAVCR2; IRF4; FSCN1; TIMP1; FLNA; DUSP4; ANXA1; CD44; BIRC3; IL2RA; GATA3; VIM; ITGB1; CD27; PTPN6; IFNG; DUSP6; HMGB1; HIF1A; ANXA2; IL16; MT2A; CCL5; CCL3; CCL4; CCL3L3; CCL4L2; BCL2; OSM; SOD1
R-HSA-109582 Hemostasis 3.29 1.85e-08 1.75e-06 27/214 RAP1A; CD58; CD2; S100A10; TAGLN2; ITGA4; F2R; LCP2; FAM3C; TIMP1; FLNA; CD44; CTSW; GATA3; ITGB1; CD9; PTPN6; PRKCH; CALM1; ANXA2; PECAM1; SIRPG; KIF3B; GNA15; PTGIR; SOD1
Factor 20 : 85 significant Reactome pathways
GeneSet description enrichRatio pValue FDR GeneRatio geneSymbols
R-HSA-389960 Formation of tubulin folding intermediates by CCT/TriC 21.30 1.31e-07 2.91e-05 6/13 CCT7; CCT5; TCP1; CCT6A; TUBB4B; CCT2
R-HSA-5626467 RHO GTPases activate IQGAPs 17.30 5.82e-07 8.60e-05 6/16 CALM2; ACTB; RAC1; TUBB4B; CALM1
R-HSA-983170 Antigen Presentation: Folding, assembly and peptide loading of class I MHC 17.00 7.11e-08 2.91e-05 7/19 CANX; HLA-A; HLA-C; HLA-B; PDIA3; B2M; CALR
R-HSA-389957 Prefoldin mediated transfer of substrate to CCT/TriC 17.00 7.11e-08 2.91e-05 7/19 CCT7; CCT5; TCP1; ACTB; CCT6A; TUBB4B; CCT2
R-HSA-389958 Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding 16.10 1.07e-07 2.91e-05 7/20 CCT7; CCT5; TCP1; ACTB; CCT6A; TUBB4B; CCT2
R-HSA-5627123 RHO GTPases activate PAKs 15.40 1.07e-05 6.95e-04 5/15 CALM2; RAC1; MYL6; CALM1
R-HSA-8978934 Metabolism of cofactors 15.40 8.91e-05 3.54e-03 4/12 CALM2; CALM1; HSP90AA1
R-HSA-6814122 Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding 14.60 1.87e-06 2.07e-04 6/19 CCT7; GNAI2; CCT5; TCP1; CCT6A; CCT2
R-HSA-5607763 CLEC7A (Dectin-1) induces NFAT activation 13.80 1.06e-03 1.91e-02 3/10 CALM2; CALM1
R-HSA-70221 Glycogen breakdown (glycogenolysis) 13.80 1.06e-03 1.91e-02 3/10 CALM2; CALM1
R-HSA-5218920 VEGFR2 mediated vascular permeability 13.60 2.14e-05 1.05e-03 5/17 CALM2; RAC1; CALM1; HSP90AA1
R-HSA-5339562 Uptake and actions of bacterial toxins 13.60 2.14e-05 1.05e-03 5/17 CALM2; HSP90AB1; CALM1; HSP90AA1
R-HSA-3371511 HSF1 activation 12.60 1.43e-03 2.26e-02 3/11 HSP90AB1; PTGES3; HSP90AA1
R-HSA-5210891 Uptake and function of anthrax toxins 12.60 1.43e-03 2.26e-02 3/11 CALM2; CALM1
R-HSA-451326 Activation of kainate receptors upon glutamate binding 12.60 1.43e-03 2.26e-02 3/11 CALM2; CALM1
R-HSA-111933 Calmodulin induced events 12.60 1.43e-03 2.26e-02 3/11 CALM2; CALM1
R-HSA-111997 CaM pathway 12.60 1.43e-03 2.26e-02 3/11 CALM2; CALM1
R-HSA-3371568 Attenuation phase 12.60 1.43e-03 2.26e-02 3/11 HSP90AB1; PTGES3; HSP90AA1
R-HSA-180024 DARPP-32 events 12.30 2.34e-04 6.68e-03 4/15 CALM2; PPP1CA; CALM1
R-HSA-157858 Gap junction trafficking and regulation 11.50 1.88e-03 2.68e-02 3/12 AP2M1; ACTB; TUBB4B
R-HSA-190828 Gap junction trafficking 11.50 1.88e-03 2.68e-02 3/12 AP2M1; ACTB; TUBB4B
R-HSA-111996 Ca-dependent events 11.50 1.88e-03 2.68e-02 3/12 CALM2; CALM1
R-HSA-5218921 VEGFR2 mediated cell proliferation 11.50 1.88e-03 2.68e-02 3/12 CALM2; CALM1
R-HSA-936837 Ion transport by P-type ATPases 10.90 3.94e-04 1.03e-02 4/17 CALM2; ATP1B3; CALM1
R-HSA-112040 G-protein mediated events 10.90 3.94e-04 1.03e-02 4/17 CALM2; GNAI2; CALM1
R-HSA-112043 PLC beta mediated events 10.90 3.94e-04 1.03e-02 4/17 CALM2; GNAI2; CALM1
R-HSA-2514856 The phototransduction cascade 10.60 2.40e-03 3.13e-02 3/13 CALM2; CALM1
R-HSA-2514859 Inactivation, recovery and regulation of the phototransduction cascade 10.60 2.40e-03 3.13e-02 3/13 CALM2; CALM1
R-HSA-8876725 Protein methylation 10.60 2.40e-03 3.13e-02 3/13 CALM2; CALM1
R-HSA-442742 CREB phosphorylation through the activation of Ras 10.60 2.40e-03 3.13e-02 3/13 CALM2; CALM1
R-HSA-5578775 Ion homeostasis 10.20 4.98e-04 1.15e-02 4/18 CALM2; ATP1B3; CALM1
R-HSA-445355 Smooth Muscle Contraction 10.20 4.98e-04 1.15e-02 4/18 CALM2; MYL6; CALM1
R-HSA-373755 Semaphorin interactions 10.00 1.05e-04 3.61e-03 5/23 HSP90AB1; RAC1; CFL1; MYL6; HSP90AA1
R-HSA-390471 Association of TriC/CCT with target proteins during biosynthesis 10.00 1.05e-04 3.61e-03 5/23 CCT7; CCT5; TCP1; CCT6A; CCT2
R-HSA-1489509 DAG and IP3 signaling 9.88 3.01e-03 3.60e-02 3/14 CALM2; CALM1
R-HSA-3371571 HSF1-dependent transactivation 9.88 3.01e-03 3.60e-02 3/14 HSP90AB1; PTGES3; HSP90AA1
R-HSA-1483249 Inositol phosphate metabolism 9.88 3.01e-03 3.60e-02 3/14 CALM2; CALM1
R-HSA-418360 Platelet calcium homeostasis 9.88 3.01e-03 3.60e-02 3/14 CALM2; CALM1
R-HSA-3928662 EPHB-mediated forward signaling 9.22 7.64e-04 1.57e-02 4/20 ACTB; RAC1; ARPC1B; CFL1
R-HSA-438064 Post NMDA receptor activation events 9.22 3.70e-03 4.15e-02 3/15 CALM2; CALM1
R-HSA-442755 Activation of NMDA receptors and postsynaptic events 9.22 3.70e-03 4.15e-02 3/15 CALM2; CALM1
R-HSA-8982491 Glycogen metabolism 9.22 3.70e-03 4.15e-02 3/15 CALM2; CALM1
R-HSA-2029482 Regulation of actin dynamics for phagocytic cup formation 8.73 1.06e-05 6.95e-04 7/37 BRK1; HSP90AB1; ACTB; RAC1; ARPC1B; CFL1; HSP90AA1
R-HSA-114608 Platelet degranulation 8.65 5.73e-07 8.60e-05 9/48 CALM2; WDR1; PPIA; CFL1; SRGN; CD63; CALM1; ALDOA
R-HSA-2672351 Stimuli-sensing channels 8.65 4.49e-03 4.73e-02 3/16 CALM2; CALM1
R-HSA-3928665 EPH-ephrin mediated repulsion of cells 8.65 4.49e-03 4.73e-02 3/16 AP2M1; ACTB; RAC1
R-HSA-425393 Transport of inorganic cations/anions and amino acids/oligopeptides 8.65 4.49e-03 4.73e-02 3/16 CALM2; CALM1
R-HSA-390466 Chaperonin-mediated protein folding 8.02 4.63e-06 4.17e-04 8/46 CCT7; GNAI2; CCT5; TCP1; ACTB; CCT6A; TUBB4B; CCT2
R-HSA-5576891 Cardiac conduction 8.02 1.33e-03 2.26e-02 4/23 CALM2; ATP1B3; CALM1
R-HSA-76005 Response to elevated platelet cytosolic Ca2+ 7.98 1.17e-06 1.48e-04 9/52 CALM2; WDR1; PPIA; CFL1; SRGN; CD63; CALM1; ALDOA
R-HSA-5663213 RHO GTPases Activate WASPs and WAVEs 7.38 1.84e-03 2.68e-02 4/25 BRK1; ACTB; RAC1; ARPC1B
R-HSA-2029480 Fcgamma receptor (FCGR) dependent phagocytosis 7.34 3.49e-05 1.63e-03 7/44 BRK1; HSP90AB1; ACTB; RAC1; ARPC1B; CFL1; HSP90AA1
R-HSA-2682334 EPH-Ephrin signaling 7.28 1.37e-04 4.34e-03 6/38 AP2M1; ACTB; RAC1; ARPC1B; CFL1; MYL6
R-HSA-391251 Protein folding 7.23 1.03e-05 6.95e-04 8/51 CCT7; GNAI2; CCT5; TCP1; ACTB; CCT6A; TUBB4B; CCT2
R-HSA-111885 Opioid Signalling 7.21 5.39e-04 1.19e-02 5/32 CALM2; GNAI2; PPP1CA; CALM1
R-HSA-112314 Neurotransmitter receptors and postsynaptic signal transmission 6.99 6.24e-04 1.32e-02 5/33 CALM2; GNAI2; AP2M1; CALM1
R-HSA-447115 Interleukin-12 family signaling 6.92 1.84e-04 5.62e-03 6/40 CANX; TCP1; PPIA; TALDO1; CFL1; P4HB
R-HSA-2151201 Transcriptional activation of mitochondrial biogenesis 6.83 2.46e-03 3.16e-02 4/27 CALM2; CYCS; CALM1
R-HSA-397014 Muscle contraction 6.75 2.12e-04 6.26e-03 6/41 CALM2; ATP1B3; VIM; MYL6; CALM1
R-HSA-9020591 Interleukin-12 signaling 6.59 8.26e-04 1.63e-02 5/35 TCP1; PPIA; TALDO1; CFL1; P4HB
R-HSA-4420097 VEGFA-VEGFR2 Pathway 6.21 1.06e-04 3.61e-03 7/52 CALM2; BRK1; ACTB; RAC1; CALM1; HSP90AA1
R-HSA-1236974 ER-Phagosome pathway 6.10 1.18e-05 6.99e-04 9/68 PSMD14; HLA-A; HLA-C; HLA-B; PDIA3; B2M; PSMD3; PSMA7; CALR
R-HSA-194138 Signaling by VEGF 6.09 1.20e-04 3.93e-03 7/53 CALM2; BRK1; ACTB; RAC1; CALM1; HSP90AA1
R-HSA-8950505 Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation 5.95 4.14e-03 4.52e-02 4/31 TCP1; PPIA; TALDO1; CFL1
R-HSA-1445148 Translocation of SLC2A4 (GLUT4) to the plasma membrane 5.89 4.56e-04 1.15e-02 6/47 CALM2; ACTB; RAC1; TUBB4B; CALM1
R-HSA-1236975 Antigen processing-Cross presentation 5.77 1.91e-05 1.05e-03 9/72 PSMD14; HLA-A; HLA-C; HLA-B; PDIA3; B2M; PSMD3; PSMA7; CALR
R-HSA-112315 Transmission across Chemical Synapses 5.36 2.14e-03 3.01e-02 5/43 CALM2; GNAI2; AP2M1; CALM1
R-HSA-877300 Interferon gamma signaling 5.01 2.89e-03 3.60e-02 5/46 HLA-A; HLA-C; HLA-B; B2M; MT2A
R-HSA-76002 Platelet activation, signaling and aggregation 4.88 1.10e-05 6.95e-04 11/104 CALM2; GNAI2; WDR1; RAC1; PPIA; CFL1; SRGN; CD63; CALM1; ALDOA
R-HSA-8852276 The role of GTSE1 in G2/M progression after G2 checkpoint 4.61 1.70e-03 2.64e-02 6/60 PSMD14; HSP90AB1; TUBB4B; HSP90AA1; PSMD3; PSMA7
R-HSA-1168372 Downstream signaling events of B Cell Receptor (BCR) 4.36 9.70e-04 1.87e-02 7/74 CALM2; PSMD14; PPIA; CALM1; PSMD3; PSMA7
R-HSA-3858494 Beta-catenin independent WNT signaling 4.24 5.04e-04 1.15e-02 8/87 CALM2; PSMD14; AP2M1; RAC1; CALM1; PSMD3; PSMA7
R-HSA-983705 Signaling by the B Cell Receptor (BCR) 3.51 3.45e-03 4.02e-02 7/92 CALM2; PSMD14; PPIA; CALM1; PSMD3; PSMA7
R-HSA-109582 Hemostasis 3.23 4.02e-05 1.78e-03 15/214 CALM2; GNAI2; ATP1B3; WDR1; ACTB; RAC1; PPIA; TUBB4B; CFL1; KIF5B; SRGN; CD63; CALM1; ALDOA
R-HSA-195258 RHO GTPase Effectors 3.06 7.77e-04 1.57e-02 11/166 CALM2; BRK1; ACTB; RAC1; ARPC1B; TUBB4B; CFL1; KIF5B; MYL6; CALM1
R-HSA-5663205 Infectious disease 3.01 4.71e-06 4.17e-04 20/306 CALM2; PSMD14; AP2M1; CANX; HSP90AB1; RAC1; PPIA; RPL39; SSRP1; RPS24; RPL41; CALM1; HSP90AA1; B2M; RPL13; PSMD3; CHMP4B; PSMA7; CALR
R-HSA-422475 Axon guidance 2.87 9.18e-05 3.54e-03 16/257 PSMD14; AP2M1; HSP90AB1; ACTB; RAC1; ARPC1B; RPL39; TUBB4B; CFL1; RPS24; RPL41; MYL6; HSP90AA1; RPL13; PSMD3; PSMA7
R-HSA-449147 Signaling by Interleukins 2.55 2.18e-03 3.01e-02 12/217 PSMD14; CANX; TCP1; PPIA; TALDO1; CFL1; VIM; HSP90B1; HSP90AA1; PSMD3; P4HB; PSMA7
R-HSA-6798695 Neutrophil degranulation 2.51 1.05e-03 1.91e-02 14/257 PSMD14; HLA-C; HLA-B; HSP90AB1; RAC1; PPIA; ERP44; TUBB4B; CD63; CCT2; HSP90AA1; B2M; ALDOA; PSMD3
R-HSA-983169 Class I MHC mediated antigen processing & presentation 2.49 4.09e-03 4.52e-02 11/204 PSMD14; CANX; HLA-A; HLA-C; HLA-B; PDIA3; B2M; PSMD3; PSMA7; CALR; UBE2S
R-HSA-194315 Signaling by Rho GTPases 2.45 4.57e-03 4.77e-02 11/207 CALM2; BRK1; ACTB; RAC1; ARPC1B; TUBB4B; CFL1; KIF5B; MYL6; CALM1
R-HSA-1280215 Cytokine Signaling in Immune system 2.41 4.70e-04 1.15e-02 17/326 PSMD14; CANX; HLA-A; HLA-C; HLA-B; TCP1; PPIA; TALDO1; CFL1; VIM; HSP90B1; HSP90AA1; B2M; MT2A; PSMD3; P4HB; PSMA7
R-HSA-168249 Innate Immune System 2.23 8.04e-05 3.39e-03 24/497 IFI16; CALM2; PSMD14; BRK1; HLA-C; HLA-B; HSP90AB1; ACTB; RAC1; PPIA; ARPC1B; ERP44; TUBB4B; CFL1; CD63; CCT2; HSP90B1; CALM1; HSP90AA1; B2M; ALDOA; PSMD3; PSMA7
R-HSA-1280218 Adaptive Immune System 2.21 6.13e-04 1.32e-02 19/397 CALM2; PSMD14; AP2M1; CANX; HLA-A; HLA-C; HLA-B; RAC1; PPIA; TUBB4B; KIF5B; CALM1; PDIA3; B2M; PSMD3; PSMA7; CALR; UBE2S
R-HSA-1266738 Developmental Biology 2.08 3.23e-03 3.82e-02 16/354 PSMD14; AP2M1; HSP90AB1; ACTB; RAC1; ARPC1B; RPL39; TUBB4B; CFL1; RPS24; RPL41; MYL6; HSP90AA1; RPL13; PSMD3; PSMA7
Summary:
Factor 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20
Signif_GO_terms 44 151 223 59 46 131 12 76 23 44 19 0 24 24 87 35 40 39 19 85

4 Gene Set Enrichment Analysis by Perturbation

Target genes: Genes w/ LFSR < 0.05 under each perturbation marker gene;
Backgroud genes: all 6000 genes used in factor analysis;
Statistical test: hypergeometric test (over-representation test);
Only GO terms/pathways that satisfy fold change \(\geq\) 2 and test FDR \(<\) 0.05 are shown below.

4.1 GO Slim Over-Representation Analysis

Gene sets: Gene ontology "Biological Process" (non-redundant).

ARID1A : 48 significant GO terms
GeneSet description enrichRatio pValue FDR GeneRatio geneSymbols
GO:1990868 response to chemokine 12.00 6.20e-06 3.38e-04 6/20 XCL2; CXCR4; CXCL10; CXCR3; CCL1; CCR7
GO:0002507 tolerance induction 10.90 2.16e-03 3.51e-02 3/11 HLA-E; IL2RA; LGALS9
GO:0034341 response to interferon-gamma 8.49 1.21e-12 8.86e-10 18/85 XCL2; STAT1; IRF1; IRF4; HLA-F; HLA-E; HLA-DRA; HLA-DRB5; HLA-DRB1; HLA-DQA1; HLA-DQB1; HLA-DPA1; HLA-DPB1; IFITM2; CD44; EVL; LGALS9; CCL1
GO:0050920 regulation of chemotaxis 7.88 8.58e-08 8.99e-06 11/56 XCL2; CXCR4; CXCL10; CD74; GPSM3; GSTP1; IL16; LGALS9; CCL1; CCR7; RAC2
GO:0002576 platelet degranulation 7.83 5.72e-06 3.38e-04 8/41 TUBA4A; TIMP1; FAM49B; CTSW; CD63; ACTN1; CALM1; PECAM1
GO:0060326 cell chemotaxis 7.39 3.22e-09 5.90e-07 14/76 XCL2; CXCR4; CXCL10; ITGA1; CD74; GPSM3; CXCR3; ANXA1; GSTP1; IL16; LGALS9; CCL1; CCR7; RAC2
GO:0032609 interferon-gamma production 6.88 1.91e-04 5.39e-03 6/35 CD96; HLA-DPA1; HLA-DPB1; FAM49B; LGALS9; CCR7
GO:0050900 leukocyte migration 6.52 1.12e-11 4.11e-09 20/123 XCL2; SELL; CXCR4; CXCL10; PTGER4; ITGA1; CD74; GPSM3; CXCR3; DOK2; ANXA1; CD44; ITGB7; IL16; LGALS9; CCL1; CCR7; PECAM1; SIRPG; RAC2
GO:0070265 necrotic cell death 6.42 3.10e-03 4.74e-02 4/25 CFLAR; BIRC3; FAS; YBX3
GO:0019882 antigen processing and presentation 6.35 2.29e-09 5.60e-07 16/101 CD8A; CD74; HLA-F; HLA-E; HLA-DRA; HLA-DRB5; HLA-DRB1; HLA-DQA1; HLA-DQB1; TAP1; HLA-DMB; HLA-DPA1; HLA-DPB1; CTSD; PSME1; CCR7
GO:0043062 extracellular structure organization 5.73 6.22e-05 2.07e-03 8/56 CAPG; CFLAR; ITGA1; FSCN1; TIMP1; CD44; ITGB7; PECAM1
GO:0032103 positive regulation of response to external stimulus 5.60 1.09e-06 8.87e-05 12/86 XCL2; CXCL10; PTGER4; CD74; HLA-E; GPSM3; NFKBIA; IL16; LGALS9; CCL1; CCR7; RAC2
GO:0097485 neuron projection guidance 5.57 1.80e-03 3.01e-02 5/36 CXCR4; EMB; DOK2; EVL; VASP
GO:0034340 response to type I interferon 5.35 7.82e-04 1.60e-02 6/45 STAT1; IRF1; IRF4; HLA-F; HLA-E; IFITM2
GO:0007159 leukocyte cell-cell adhesion 4.95 5.02e-09 7.36e-07 19/154 SELL; IRF1; CD74; HLA-E; HLA-DMB; HLA-DPA1; HLA-DPB1; FAM49B; ANXA1; CD44; IL2RA; ITGB7; LGALS9; CCR7; PECAM1; SIRPG; TMIGD2; RAC2; LGALS1
GO:0001655 urogenital system development 4.94 1.83e-04 5.37e-03 8/65 ID3; ID2; STAT1; CFLAR; AHI1; ANXA1; ARID5B; PECAM1
GO:0019932 second-messenger-mediated signaling 4.90 1.17e-05 5.71e-04 11/90 CXCR4; ITPR1; CXCL10; PTGER4; HINT1; PRKAR1B; CXCR3; TBC1D10C; CALM1; NFATC3; CCR7
GO:0070371 ERK1 and ERK2 cascade 4.89 3.03e-05 1.31e-03 10/82 XCL2; CFLAR; PTGER4; CD74; CD44; TBC1D10C; GSTP1; LGALS9; CCL1; CCR7
GO:0050866 negative regulation of cell activation 4.84 5.29e-04 1.20e-02 7/58 ID2; IRF1; CD74; ANXA1; TBC1D10C; IL2RA; LGALS9
GO:0070661 leukocyte proliferation 4.70 2.92e-06 1.95e-04 13/111 IRF1; CD74; HLA-E; HLA-DMB; HLA-DPA1; HLA-DPB1; CCND3; ANXA1; GSTP1; IL2RA; LGALS9; TMIGD2; RAC2
GO:0031589 cell-substrate adhesion 4.56 5.64e-05 2.07e-03 10/88 CD96; ITGA1; CD44; ITGB7; CD63; ACTN1; CCR7; PECAM1; RAC2; LGALS1
GO:0009612 response to mechanical stimulus 4.46 8.79e-04 1.70e-02 7/63 STAT1; CXCL10; PTGER4; IRF1; FAS; NFKBIA; JUNB
GO:0050727 regulation of inflammatory response 3.97 1.83e-04 5.37e-03 10/101 PTGER4; HLA-E; GPSM3; ANXA1; GSTP1; BIRC3; IL2RA; NFKBIA; CCL1; CCR7
GO:0042110 T cell activation 3.94 4.60e-08 5.63e-06 21/214 CD8A; PTGER4; IRF1; CD74; IRF4; HLA-E; HLA-DMB; HLA-DPA1; HLA-DPB1; CCND3; FAM49B; SIT1; ANXA1; IL2RA; LGALS9; CCR7; CD7; SIRPG; TMIGD2; RAC2; LGALS1
GO:0001819 positive regulation of cytokine production 3.91 2.34e-06 1.72e-04 16/164 STAT1; PTGER4; IRF1; CD74; IRF4; HLA-E; GPSM3; HLA-DPA1; HLA-DPB1; FAM49B; ANXA1; BIRC3; LGALS9; CCL1; CCR7; TMIGD2
GO:0022407 regulation of cell-cell adhesion 3.83 6.46e-06 3.38e-04 15/157 IRF1; CD74; HLA-E; HLA-DMB; HLA-DPA1; HLA-DPB1; FAM49B; ANXA1; CD44; IL2RA; LGALS9; CCR7; SIRPG; TMIGD2; LGALS1
GO:0007249 I-kappaB kinase/NF-kappaB signaling 3.82 5.95e-05 2.07e-03 12/126 RHOC; STAT1; CFLAR; CD74; PIM2; GSTP1; BIRC3; NFKBIA; LITAF; LGALS9; CCR7; LGALS1
GO:0045785 positive regulation of cell adhesion 3.72 1.90e-05 8.70e-04 14/151 CD74; HLA-E; HLA-DMB; HLA-DPA1; HLA-DPB1; FAM49B; ANXA1; CD44; IL2RA; LGALS9; CCR7; SIRPG; TMIGD2; LGALS1
GO:0050867 positive regulation of cell activation 3.67 4.39e-05 1.79e-03 13/142 CD74; HLA-E; HLA-DMB; HLA-DPA1; HLA-DPB1; FAM49B; ANXA1; IL2RA; LGALS9; CCR7; SIRPG; TMIGD2; LGALS1
GO:0003013 circulatory system process 3.65 1.44e-03 2.46e-02 8/88 XCL2; ID2; STAT1; ITPR1; CXCL10; ITGA1; ATP2B1; CALM1
GO:0002694 regulation of leukocyte activation 3.65 7.24e-07 6.63e-05 19/209 ID2; IRF1; CD74; IRF4; HLA-E; HLA-DMB; HLA-DPA1; HLA-DPB1; FAM49B; SIT1; ANXA1; TBC1D10C; IL2RA; LGALS9; CCR7; SIRPG; TMIGD2; RAC2; LGALS1
GO:0002237 response to molecule of bacterial origin 3.61 7.85e-04 1.60e-02 9/100 CD96; CXCL10; PTGER4; GSTP1; NFKBIA; LITAF; LGALS9; CCR7; JUNB
GO:0002697 regulation of immune effector process 3.57 5.88e-05 2.07e-03 13/146 STAT1; CD96; CD74; IRF4; HLA-F; HLA-E; HLA-DMB; FAM49B; ANXA1; BIRC3; IL2RA; LGALS9; RAC2
GO:0002449 lymphocyte mediated immunity 3.54 9.06e-04 1.70e-02 9/102 CD8A; CD96; CD74; HLA-F; HLA-E; HLA-DQB1; FAM49B; GZMB; LGALS9
GO:0072507 divalent inorganic cation homeostasis 3.39 3.50e-04 8.56e-03 11/130 CD52; CXCR4; ITPR1; CXCL10; PTGER4; CXCR3; ATP2B1; CALM1; HERPUD1; CCL1; CCR7
GO:0097191 extrinsic apoptotic signaling pathway 3.38 2.36e-03 3.76e-02 8/95 CFLAR; ITM2C; SIAH2; TRAF1; GSTP1; FAS; SIVA1; PMAIP1
GO:0048872 homeostasis of number of cells 3.34 7.39e-04 1.59e-02 10/120 ID2; STAT1; CD74; SIT1; ANXA1; IL2RA; RPS17; LGALS9; CCR7; PMAIP1
GO:0052547 regulation of peptidase activity 3.32 1.25e-04 3.97e-03 13/157 CFLAR; SIAH2; TNFAIP8; PSMB9; TIMP1; CD44; BIRC3; FAS; PSME1; PSME2; HERPUD1; LGALS9; PMAIP1
GO:0034612 response to tumor necrosis factor 3.31 2.69e-03 4.20e-02 8/97 XCL2; STAT1; TRAF1; GSTP1; BIRC3; YBX3; NFKBIA; CCL1
GO:0002250 adaptive immune response 3.27 2.63e-04 6.87e-03 12/147 CD8A; IRF1; CD74; IRF4; HLA-F; HLA-E; HLA-DQB1; TAP1; FAM49B; SIT1; ANXA1; CD7
GO:0009615 response to virus 3.25 2.80e-04 7.07e-03 12/148 BATF3; CXCR4; STAT1; CXCL10; IRF1; PIM2; IFITM2; BIRC3; IL2RA; RPS15A; LGALS9; PMAIP1
GO:0007015 actin filament organization 3.13 1.22e-03 2.13e-02 10/128 RHOC; TMSB10; CAPG; PTGER4; FSCN1; ACTN1; EVL; CCR7; VASP; RAC2
GO:0002683 negative regulation of immune system process 3.03 5.41e-04 1.20e-02 12/159 ID2; CD96; PTGER4; IRF1; CD74; IRF4; HLA-E; ANXA1; TBC1D10C; IL2RA; NFKBIA; LGALS9
GO:0002764 immune response-regulating signaling pathway 2.84 2.19e-04 5.95e-03 15/212 IRF1; IRF4; HLA-DRA; HLA-DRB5; HLA-DRB1; HLA-DQA1; HLA-DQB1; HLA-DPA1; HLA-DPB1; BIRC3; NFKBIA; CALM1; NFATC3; LGALS9; CCR7
GO:0030099 myeloid cell differentiation 2.83 9.85e-04 1.80e-02 12/170 BATF3; ID2; STAT1; CD74; IRF4; KMT2A; TESC; NFKBIA; ACTN1; LGALS9; CCR7; JUNB
GO:1903706 regulation of hemopoiesis 2.81 1.04e-03 1.85e-02 12/171 ID2; STAT1; IRF1; CD74; IRF4; ANXA1; KMT2A; IL2RA; TESC; NFKBIA; LGALS9; LGALS1
GO:0002521 leukocyte differentiation 2.78 4.45e-04 1.05e-02 14/202 BATF3; ID2; CD8A; PTGER4; IRF1; CD74; IRF4; ANXA1; IL2RA; TESC; LGALS9; CCR7; JUNB; LGALS1
GO:2001233 regulation of apoptotic signaling pathway 2.74 8.10e-04 1.61e-02 13/190 CFLAR; ITM2C; SIAH2; CD74; TRAF1; CD44; GSTP1; FAS; YBX3; GZMB; HERPUD1; LGALS9; PMAIP1
CBLB : 46 significant GO terms
GeneSet description enrichRatio pValue FDR GeneRatio geneSymbols
GO:0070972 protein localization to endoplasmic reticulum 5.26 0.00e+00 0.00e+00 68/121 RPL22; RPS8; RPL5; RPS7; RPS27A; RPL31; RPL37A; RPL32; RPL14; RPL29; RPL24; RPL35A; RPL9; RPL34; RPS3A; RPL37; RPS23; RPS14; RPS18; RPS10; RPL10A; RPS12; RPL36A; RPL39; RPS20; RPL7; RPL30; RPL8; RPS6; SEC61B; RPL35; HSPA5; RPL12; RPL7A; RPL27A; RPS13; RPS25; RPS24; RPS26; RPL41; RPL6; RPLP0; RPL21; RPS29; RPL4; RPLP1; RPS17; RPS2; RPS15A; RPL13; RPL26; RPL23A; RPL23; RPL19; RPL27; RPL38; RPL17; RPS21; RPS15; RPL36; RPL18A; UBA52; RPS16; RPL18; RPL13A; RPS9; RPS5; RPL3
GO:0051131 chaperone-mediated protein complex assembly 4.68 7.60e-04 1.24e-02 6/12 HSPD1; HOPX; HSP90AB1; PTGES3; CCT2; HSP90AA1
GO:0042092 type 2 immune response 4.68 2.18e-03 2.58e-02 5/10 XCL1; NDFIP1; CD74; GATA3; BATF
GO:0006413 translational initiation 4.62 0.00e+00 0.00e+00 79/160 RPL22; RPS8; RPL5; RPS7; RPS27A; EIF5B; RPL31; RPL37A; RPL32; RPL14; RPL29; RPL24; EIF4G1; RPL35A; RPL9; RPL34; ABCE1; RPS3A; RPL37; RPS23; RPS14; NPM1; RPS18; RPS10; RPL10A; RPS12; HSPB1; EIF1AX; RPL36A; RPL39; RPS20; RPL7; RPL30; RPL8; RPS6; RPL35; RPL12; RPL7A; EIF3F; RPL27A; EIF4G2; RPS13; EIF3M; PPP1CA; RPS25; RPS24; RPS26; RPL41; RPL6; RPLP0; RPL21; RPS29; RPL4; RPLP1; RPS17; RPS2; RPS15A; RPL13; RPL26; RPL23A; RPL23; RPL19; RPL27; RPL38; RPL17; EIF2S2; RPS21; RPS15; RPL36; RPL18A; UBA52; EIF3K; RPS16; RPL18; RPL13A; RPS9; RPS5; RPL3; ATF4
GO:0002181 cytoplasmic translation 4.05 4.18e-13 5.11e-11 32/74 RPL31; RPL32; RPL29; RPL24; EIF4G1; RPL35A; RPL9; RPS23; ETF1; RPL10A; RPL36A; RPL39; RPL30; RPL8; EIF3F; EIF3M; RPS26; RPL41; RPL6; RPLP0; RPS29; RPLP1; RPL26; RPL19; RPL38; RPL17; RPS21; RPL36; RPL18A; EIF3K; RPL18; RPL13A
GO:0090150 establishment of protein localization to membrane 3.81 0.00e+00 0.00e+00 83/204 RPL22; RPS8; RPL5; RPS7; SPTBN1; RPS27A; RPL31; CASP8; RPL37A; RPL32; RPL14; RPL29; RPL24; RPL35A; RPL9; RPL34; RPS3A; RPL37; RPS23; RPS14; RPS18; RPS10; RPL10A; FYN; RPS12; AGK; RPL36A; RPL39; RPS20; RPL7; RPL30; YWHAZ; RPL8; RPS6; SEC61B; RPL35; RPL12; RPL7A; RPL27A; RPS13; RPS25; ANK3; RPS24; RPS26; RPL41; RPL6; RPLP0; RILPL2; RPL21; GZMB; RPS29; CALM1; HSP90AA1; RPL4; RPLP1; RPS17; RPS2; RPS15A; ARL6IP1; RPL13; YWHAE; RPL26; RPL23A; RPL23; RPL19; RPL27; RPL38; RPL17; PMAIP1; YWHAB; RPS21; RPS15; TIMM13; RPL36; RPL18A; UBA52; PDCD5; RPS16; RPL18; RPL13A; RPS9; RPS5; RPL3
GO:0070670 response to interleukin-4 3.66 3.50e-04 6.45e-03 9/23 XCL1; IMPDH2; LEF1; HSP90AB1; HSPA5; GATA3; CDK4; CORO1A; RPL3
GO:0032633 interleukin-4 production 3.51 4.53e-03 4.37e-02 6/16 CD28; RBPJ; LEF1; NDFIP1; HLA-E; GATA3
GO:0006959 humoral immune response 3.38 4.64e-05 1.62e-03 13/36 PTPRC; CD28; RBPJ; HLA-E; HLA-DQB1; RPL39; SH2D1A; RPL30; GATA3; IFNG; RGCC; C1QBP; PHB
GO:0006401 RNA catabolic process 3.22 0.00e+00 0.00e+00 87/253 RPL22; MRTO4; YBX1; RPS8; SERBP1; RPL5; RPS7; ZFP36L2; RPS27A; RPL31; RPL37A; RPL32; RPL14; RPL29; RPL24; EIF4G1; RPL35A; RPL9; RPL34; RPS3A; RPL37; RPS23; ETF1; RPS14; NPM1; RPS18; RPS10; RPL10A; SYNCRIP; RPS12; LSM5; HSPB1; RPL36A; RPL39; DKC1; RPS20; RPL7; RPL30; YWHAZ; RPL8; RPS6; RPL35; RPL12; SET; RPL7A; RPL27A; RPS13; ATM; RPS25; VIM; RPS24; RPS26; RPL41; RPL6; RPLP0; RPL21; RNASEH2B; RPS29; ZFP36L1; SLIRP; RPL4; RPLP1; RPS17; ISG20; RPS2; CARHSP1; RPS15A; RPL13; RPL26; RPL23A; RPL23; RPL19; RPL27; RPL38; RPL17; YWHAB; RPS21; RPS15; RPL36; RPL18A; UBA52; RPS16; RPL18; RPL13A; RPS9; RPS5; RPL3
GO:0034109 homotypic cell-cell adhesion 3.01 1.81e-03 2.33e-02 9/28 CLIC1; ACTB; HSPB1; FLNA; ANK3; CD9; ACTG1; MYL12A; MYH9
GO:0030048 actin filament-based movement 2.99 3.35e-03 3.61e-02 8/25 BIN1; FLNA; VIM; MYL6; SYNE2; TPM4; MYH9; SUN2
GO:0006605 protein targeting 2.97 0.00e+00 0.00e+00 81/255 RPL22; RPS8; RPL5; RPS7; RPS27A; RPL31; HSPD1; RPL37A; RPL32; RPL14; RPL29; RPL24; RPL35A; RPL9; RPL34; RPS3A; RPL37; RPS23; RPS14; RPS18; RPS10; RPL10A; FYN; RPS12; AGK; RPL36A; RPL39; RPS20; RPL7; RPL30; YWHAZ; RPL8; RPS6; SEC61B; RPL35; RPL12; RPL7A; RPL27A; RPS13; RPS25; SORL1; ANK3; RPS24; RPS26; RPL41; RPL6; RPLP0; RPL21; RPS29; HSP90AA1; RPL4; RPLP1; RPS17; RPS2; RPS15A; ARL6IP1; RPL13; RPL26; RPL23A; RPL23; RPL19; RPL27; RPL38; RPL17; YWHAB; RPS21; RPS15; TIMM13; RPL36; UBL5; RPL18A; UBA52; PDCD5; RPS16; TOMM40; RPL18; RPL13A; RPS9; RPS5; RAC2; RPL3
GO:0043491 protein kinase B signaling 2.89 4.10e-06 2.51e-04 21/68 PARK7; LCK; CD28; TRAT1; HPSE; ADTRP; HSP90AB1; FYN; MTDH; TXN; PRKCDBP; SESN3; GATA3; ZFP36L1; HSP90AA1; ARRB2; C1QBP; CCL3; SLC9A3R1; GLTSCR2; RAC2
GO:0001906 cell killing 2.79 5.62e-05 1.72e-03 17/57 XCL1; PTPRC; LYST; IL7R; SERPINB9; HLA-E; HSP90AB1; SH2D1A; RPL30; CRTAM; LAG3; IFNG; GZMB; B2M; CTSH; CORO1A; ARRB2
GO:0034341 response to interferon-gamma 2.75 1.37e-06 1.12e-04 25/85 XCL2; XCL1; STAT1; TXK; HLA-E; HLA-DRA; HLA-DRB5; HLA-DRB1; HLA-DQA1; HLA-DQB1; HLA-DPA1; HLA-DPB1; HSP90AB1; SYNCRIP; CD44; VIM; IFNG; EVL; B2M; MT2A; CCL1; CCL3; CCL4L2; ACTG1; RPL13A
GO:0048013 ephrin receptor signaling pathway 2.72 3.95e-03 4.02e-02 9/31 ARPC5; ARPC2; RBPJ; FYN; ACTB; ARPC1B; ARPC3; ACTG1; AP2S1
GO:0008277 regulation of G protein-coupled receptor signaling pathway 2.67 2.75e-03 3.11e-02 10/35 STMN1; RAMP1; GNAI2; GRK6; NMT2; CALM1; ARRB2; PHB; ADA; YWHAB
GO:0009566 fertilization 2.60 3.46e-03 3.67e-02 10/36 PARK7; CCT3; H3F3A; CCT5; TCP1; CD9; CCT2; HVCN1; SLIRP; BCL2L1
GO:0043270 positive regulation of ion transport 2.58 2.55e-04 5.67e-03 16/58 PARK7; XCL1; VAMP8; PRELID1; TMSB4X; FLNA; ANK3; CALM1; ANXA2; ARL6IP1; ARRB2; CCL3; CCL4L2; SLC9A3R1; CHCHD10; ATF4
GO:0008037 cell recognition 2.53 4.30e-03 4.31e-02 10/37 CCT3; CCT5; EMB; TCP1; YWHAZ; CRTAM; CD9; CCT2; HVCN1; CORO1A
GO:0008637 apoptotic mitochondrial changes 2.48 1.89e-04 4.78e-03 18/68 JUN; LMNA; HSPD1; CASP8; TNFSF10; PRELID1; GGCT; SLC25A5; YWHAZ; GZMB; PYCARD; YWHAE; ARRB2; PMAIP1; BCL2L1; YWHAB; PDCD5; CHCHD10
GO:0070555 response to interleukin-1 2.42 8.37e-04 1.27e-02 15/58 XCL2; XCL1; RPS27A; SKP1; IGBP1; MAP3K8; NFKBIA; PYCARD; CYBA; CCL1; CCL3; CCL4L2; AES; KLF2; UBA52
GO:0070661 leukocyte proliferation 2.36 9.07e-06 4.75e-04 28/111 TNFRSF4; XCL1; PTPRC; HSPD1; CD28; IMPDH2; SELK; LEF1; IL7R; NDFIP1; CD74; HLA-E; LST1; HLA-DMB; HLA-DPA1; HLA-DPB1; CCND3; FYN; RPS6; ATM; CRTAM; IL2RA; CORO1A; PYCARD; ADA; TNFSF14; CD320; RAC2
GO:0050900 leukocyte migration 2.36 3.05e-06 2.04e-04 31/123 TNFRSF18; LCK; XCL2; XCL1; SELL; LYST; GYPC; ITGA4; SELK; WDR1; CD74; ADTRP; FAM65B; GPSM3; FYN; MYO1G; CD44; SLC3A2; GATA3; SELPLG; CORO1A; PYCARD; C1QBP; CCL1; CCL3; CCL4L2; ADA; TNFSF14; CALR; MYH9; RAC2
GO:0050920 regulation of chemotaxis 2.34 1.77e-03 2.31e-02 14/56 XCL2; XCL1; CD74; FAM65B; GPSM3; HSPB1; TMSB4X; C1QBP; CCL1; CCL3; CCL4L2; TNFSF14; CALR; RAC2
GO:0060326 cell chemotaxis 2.34 2.85e-04 5.96e-03 19/76 XCL2; XCL1; LYST; LEF1; CD74; FAM65B; GPSM3; HSPB1; TMSB4X; BIN2; CORO1A; ARRB2; C1QBP; CCL1; CCL3; CCL4L2; TNFSF14; CALR; RAC2
GO:1902600 proton transmembrane transport 2.31 3.41e-04 6.45e-03 19/77 PARK7; ATP5G3; NDUFA4; TMSB4X; COX6C; CYC1; STOML2; COX8A; ATP5L; HVCN1; ATP5G1; SLC9A3R1; ATP5E; ATP5D; COX6B1; CHCHD10; MT-CO1; MT-CO3; MT-CYB
GO:0032103 positive regulation of response to external stimulus 2.29 1.97e-04 4.78e-03 21/86 PARK7; XCL2; XCL1; VAMP8; HSPD1; CD28; CD74; FAM65B; HLA-E; GPSM3; HSPB1; TMSB4X; NFKBIA; CYBA; C1QBP; CCL1; CCL3; CCL4L2; TNFSF14; CALR; RAC2
GO:0070371 ERK1 and ERK2 cascade 2.28 2.83e-04 5.96e-03 20/82 JUN; XCL2; XCL1; PTPRC; ZFP36L2; CFLAR; GNAI2; CD74; DUSP4; PRKCDBP; CD44; ZFP36L1; CTSH; PYCARD; ARRB2; CCL1; CCL3; CCL4L2; PHB; SLC9A3R1
GO:0045785 positive regulation of cell adhesion 2.23 2.02e-06 1.48e-04 36/151 TNFRSF18; LCK; S100A10; XCL1; PTPRC; DPP4; ITGA4; HSPD1; CD28; ARPC2; SELK; IL7R; CD74; HLA-E; HLA-DMB; HLA-DPA1; HLA-DPB1; FYN; CDK6; FLNA; NINJ1; CD44; ATM; IL2RA; GATA3; MAP3K8; ANK3; IFNG; HSPH1; CORO1A; PYCARD; C1QBP; ADA; TNFSF14; CALR; GRAP2
GO:0019882 antigen processing and presentation 2.22 1.11e-04 3.26e-03 24/101 CAPZB; VAMP8; ACTR1B; CD74; HLA-E; HLA-DRA; HLA-DRB5; HLA-DRB1; HLA-DQA1; HLA-DQB1; PSMB8; TAP1; HLA-DMB; HLA-DPA1; HLA-DPB1; DCTN3; LAG3; PSME1; B2M; CTSH; PYCARD; KIF3B; CALR; AP2S1
GO:0034612 response to tumor necrosis factor 2.22 1.59e-04 4.17e-03 23/97 TNFRSF18; TNFRSF4; TNFRSF9; XCL2; XCL1; ZFP36L2; STAT1; CASP8; LTB; TMSB4X; IGBP1; TRAF1; GATA3; NFKBIA; ZFP36L1; PYCARD; CYBA; CCL1; CCL3; CCL4L2; CD70; TNFSF14; KLF2
GO:0032970 regulation of actin filament-based process 2.20 3.66e-05 1.45e-03 28/119 CAPZB; STMN1; S100A10; ARPC5; SPTBN1; TMSB10; CAPG; BIN1; ARPC2; WDR1; ABRACL; ARPC1B; TMSB4X; FLNA; ARPC5L; CFL1; ADD3; ARHGDIB; ARPC3; RGCC; EVL; CORO1A; PYCARD; PFN1; CNN2; GMFG; MYH9; SH3BP1
GO:0002449 lymphocyte mediated immunity 2.20 1.31e-04 3.56e-03 24/102 XCL1; PTPRC; LYST; HSPD1; CD28; IL7R; NDFIP1; CD74; SERPINB9; HLA-E; HLA-DQB1; MYO1G; SH2D1A; CRTAM; GATA3; LAG3; KLRD1; GZMB; BATF; B2M; CTSH; CORO1A; ARRB2; C1QBP
GO:0042110 T cell activation 2.19 3.83e-08 3.51e-06 50/214 TNFRSF18; TNFRSF4; LCK; XCL1; PTPRC; ZFP36L2; CD8B; DPP4; HSPD1; CASP8; CD28; SELK; TIGIT; LEF1; IL7R; CAMK4; NDFIP1; CD74; PRELID1; FAM65B; HLA-E; HLA-DMB; HLA-DPA1; HLA-DPB1; CCND3; FYN; RPS6; STOML2; CD3D; CD3G; CRTAM; IL2RA; GATA3; MAP3K8; LAG3; IFNG; HSPH1; LCP1; ZFP36L1; BATF; BCL11B; B2M; CORO1A; PYCARD; CD7; ADA; TNFSF14; MYH9; RAC2; GRAP2
GO:0022407 regulation of cell-cell adhesion 2.15 5.34e-06 3.01e-04 36/157 LCK; XCL1; PTPRC; DPP4; ITGA4; HSPD1; CD28; SELK; TIGIT; LEF1; IL7R; NDFIP1; CD74; ADTRP; FAM65B; HLA-E; HLA-DMB; HLA-DPA1; HLA-DPB1; FYN; CD44; IL2RA; GATA3; MAP3K8; ANK3; CD9; LAG3; IFNG; HSPH1; RGCC; CORO1A; PYCARD; MBP; ADA; TNFSF14; GRAP2
GO:0007015 actin filament organization 2.12 5.62e-05 1.72e-03 29/128 CAPZB; STMN1; CAP1; S100A10; ARPC5; SPTBN1; TMSB10; CAPG; BIN1; ARPC2; WDR1; ARPC1B; TMSB4X; FLNA; ARPC5L; MICAL2; CFL1; ADD3; ARPC3; RGCC; LCP1; EVL; CORO1A; PYCARD; PFN1; TPM4; GMFG; RAC2; SH3BP1
GO:0007006 mitochondrial membrane organization 2.10 8.83e-04 1.27e-02 20/89 ATP5G3; CASP8; HEBP2; AGK; SLC25A5; YWHAZ; ATP5L; GZMB; CALM1; HSP90AA1; YWHAE; ATP5G1; PMAIP1; BCL2L1; YWHAB; ATP5E; ATP5D; TIMM13; PDCD5; CHCHD10
GO:0007159 leukocyte cell-cell adhesion 2.07 2.31e-05 1.06e-03 34/154 LCK; XCL1; SELL; PTPRC; DPP4; ITGA4; HSPD1; CD28; SELK; TIGIT; IL7R; NDFIP1; CD74; ADTRP; FAM65B; HLA-E; HLA-DMB; HLA-DPA1; HLA-DPB1; FYN; CD44; IL2RA; GATA3; MAP3K8; LAG3; IFNG; SELPLG; HSPH1; CORO1A; PYCARD; ADA; TNFSF14; RAC2; GRAP2
GO:2000147 positive regulation of cell motility 2.07 2.31e-05 1.06e-03 34/154 TNFRSF18; JUN; XCL2; XCL1; PTPRC; ITGA4; GNAI2; SELK; LEF1; CD74; FAM65B; GPSM3; HSPB1; TMSB4X; FLNA; HSPA5; FAM89B; ATM; GATA3; IFNG; SYNE2; CTSH; CORO1A; PYCARD; PFN1; C1QBP; MAP2K3; CCL1; CCL3; CCL4L2; TNFSF14; CALR; RAC2; SUN2
GO:0002250 adaptive immune response 2.04 5.40e-05 1.72e-03 32/147 XCL1; PTPRC; CD8B; HSPD1; CD28; TRAT1; TXK; LEF1; IL7R; CAMK4; NDFIP1; CD74; HLA-E; HLA-DQB1; TAP1; FYN; MYO1G; SH2D1A; CD3D; CD3G; CRTAM; GATA3; NFKB2; IFNG; BATF; B2M; CTSH; PYCARD; C1QBP; CD7; ADA; LAIR1
GO:0090130 tissue migration 2.03 2.41e-03 2.76e-02 18/83 JUN; CYP1B1; ZEB2; DPP4; STAT1; ADTRP; HSPB1; TMSB4X; GATA3; IFNG; RGCC; EVL; CTSH; PFN1; MAP2K3; CALR; MYH9; SH3BP1
GO:0006909 phagocytosis 2.02 1.95e-03 2.38e-02 19/88 ARPC5; PTPRC; ARPC2; HSP90AB1; FYN; ACTB; MYO1G; ARPC1B; CD3G; BIN2; ARPC3; HSP90AA1; CORO1A; PYCARD; CYBA; ACTG1; CALR; MYH9; SH3BP1
GO:0001667 ameboidal-type cell migration 2.01 7.25e-04 1.24e-02 23/107 CAP1; JUN; CYP1B1; ZEB2; DPP4; ITGA4; STAT1; ADTRP; HSPB1; TMSB4X; CFL1; GATA3; ARHGDIB; IFNG; RGCC; EVL; CTSH; PFN1; C1QBP; MAP2K3; CALR; MYH9; SH3BP1
GO:1902903 regulation of supramolecular fiber organization 2.01 3.35e-04 6.45e-03 26/121 PARK7; CAPZB; STMN1; S100A10; ARPC5; SPTBN1; TMSB10; CAPG; BIN1; ARPC2; WDR1; ARPC1B; TMSB4X; FLNA; ARPC5L; CFL1; ADD3; FKBP4; ARPC3; RGCC; EVL; CORO1A; PYCARD; PFN1; GMFG; SH3BP1
CD3D : 86 significant GO terms
GeneSet description enrichRatio pValue FDR GeneRatio geneSymbols
GO:1990868 response to chemokine 8.53 1.61e-06 1.15e-04 8/20 XCL2; XCL1; FAM65B; CXCR3; CCL1; CCL3; CCL3L3; CCL4L2
GO:0042092 type 2 immune response 8.53 7.92e-04 1.14e-02 4/10 XCL1; NDFIP1; GATA3; BATF
GO:0001773 myeloid dendritic cell activation 8.00 5.38e-05 1.58e-03 6/16 CD2; RBPJ; CAMK4; CSF2; BATF; PYCARD
GO:0042490 mechanoreceptor differentiation 7.75 1.20e-03 1.54e-02 4/11 RBPJ; FAM65B; SLC9A3R1; SOD1
GO:0032633 interleukin-4 production 6.66 6.20e-04 9.47e-03 5/16 FCER1G; RBPJ; LEF1; NDFIP1; GATA3
GO:0034113 heterotypic cell-cell adhesion 6.66 6.20e-04 9.47e-03 5/16 LCK; CD58; CD2; ITGA4; CD44
GO:0002437 inflammatory response to antigenic stimulus 6.27 8.46e-04 1.17e-02 5/17 PARK7; FCER1G; RBPJ; IL2RA; GATA3
GO:0061053 somite development 6.09 3.25e-03 3.31e-02 4/14 ZEB2; BHLHE40; RBPJ; LEF1
GO:0007187 G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger 5.33 8.21e-05 2.07e-03 8/32 RGS1; RAMP1; PTGER4; HRH2; SLC9A3R1; S1PR4; ADGRE5; PTGIR
GO:1904019 epithelial cell apoptotic process 5.33 2.32e-04 4.47e-03 7/28 ITGA4; CFLAR; CAST; GATA3; RGCC; ZFP36L1; BCL2L1
GO:0032613 interleukin-10 production 5.33 5.49e-03 4.68e-02 4/16 FCER1G; XCL1; TIGIT; PYCARD
GO:0002065 columnar/cuboidal epithelial cell differentiation 5.12 8.33e-04 1.17e-02 6/25 RBPJ; LEF1; FAM65B; CDK6; SLC9A3R1; SOD1
GO:0050663 cytokine secretion 5.08 1.22e-07 1.79e-05 15/63 TNFRSF4; CD58; CD2; SPTBN1; SELK; RBPJ; PTGER4; CRTAM; GATA3; SRGN; RGCC; SOCS1; PYCARD; CCL1; CCL3
GO:0034612 response to tumor necrosis factor 4.84 3.32e-10 1.22e-07 22/97 TNFRSF18; TNFRSF4; TNFRSF9; CD58; XCL2; XCL1; ZFP36L2; LTB; TRAF1; BIRC3; GATA3; NFKBIA; ZFP36L1; PYCARD; CYBA; CCL1; CCL3; CCL3L3; CCL4L2; CD70; TNFSF14; KLF2
GO:0050900 leukocyte migration 4.51 4.03e-11 2.96e-08 26/123 TNFRSF18; LCK; CD58; CD2; FCER1G; XCL2; XCL1; SELL; LYST; GYPC; ITGA4; SELK; PTGER4; FAM65B; FYN; CXCR3; CD44; GATA3; SELPLG; PYCARD; CCL1; CCL3; CCL3L3; CCL4L2; ADA; TNFSF14
GO:0070371 ERK1 and ERK2 cascade 4.42 1.53e-07 1.87e-05 17/82 JUN; XCL2; XCL1; ZFP36L2; CFLAR; PTGER4; DUSP4; PRKCDBP; CD44; ZFP36L1; CTSH; PYCARD; CCL1; CCL3; CCL3L3; CCL4L2; SLC9A3R1
GO:0070555 response to interleukin-1 4.41 1.12e-05 4.55e-04 12/58 XCL2; XCL1; MAP3K8; NFKBIA; PYCARD; CYBA; CCL1; CCL3; CCL3L3; CCL4L2; AES; KLF2
GO:0009612 response to mechanical stimulus 4.40 4.92e-06 2.58e-04 13/63 JUN; TXNIP; BTG2; PTGER4; FAM65B; FYN; BNIP3; NFKBIA; CYBA; CNN2; TNFSF14; JUNB; JUND
GO:0043583 ear development 4.26 4.33e-04 7.56e-03 8/40 RBPJ; FAM65B; AHI1; RDH10; GATA3; MAF; SLC9A3R1; SOD1
GO:0001906 cell killing 4.12 5.19e-05 1.58e-03 11/57 PRDX1; XCL1; LYST; GNLY; IL7R; SERPINB9; CRTAM; LAG3; IFNG; GZMB; CTSH
GO:0060326 cell chemotaxis 3.93 8.63e-06 3.95e-04 14/76 FCER1G; XCL2; XCL1; LYST; LEF1; FAM65B; HSPB1; CXCR3; BIN2; CCL1; CCL3; CCL3L3; CCL4L2; TNFSF14
GO:0046683 response to organophosphorus 3.76 4.44e-03 4.02e-02 6/34 JUN; SELL; ZFP36L1; JUNB; JUND; SOD1
GO:1904950 negative regulation of establishment of protein localization 3.71 6.97e-05 1.82e-03 12/69 TNFRSF4; PARK7; PTGER4; NDFIP1; MDFIC; RAB11FIP1; SRGN; ERP29; RGCC; NDFIP2; IDH2; PIM3
GO:0032103 positive regulation of response to external stimulus 3.47 3.74e-05 1.31e-03 14/86 PARK7; FCER1G; XCL2; XCL1; PTGER4; FAM65B; HSPB1; NFKBIA; CYBA; CCL1; CCL3; CCL3L3; CCL4L2; TNFSF14
GO:0003007 heart morphogenesis 3.47 3.46e-03 3.47e-02 7/43 DHRS3; JUN; ID2; RBPJ; AHI1; MICAL2; GATA3
GO:0045444 fat cell differentiation 3.43 1.03e-03 1.38e-02 9/56 ID2; ZFP36L2; PSMB8; TMEM120A; GATA3; BNIP3; ZFP36L1; SOCS1; ATF5
GO:0002791 regulation of peptide secretion 3.40 3.11e-07 2.85e-05 22/138 TNFRSF4; CD58; CD2; GLUL; SPTBN1; ITPR1; SELK; PTGER4; RAB11FIP1; CRTAM; GATA3; SRGN; IFNG; ERP29; RGCC; IDH2; SOCS1; PYCARD; CCL1; CCL3; KCNN4; PIM3
GO:0071241 cellular response to inorganic substance 3.35 3.55e-04 6.34e-03 11/70 JUN; ID2; CFLAR; RASGRP2; ANK3; BNIP3; ALOX5AP; MT2A; JUNB; JUND; SOD1
GO:0048017 inositol lipid-mediated signaling 3.32 4.50e-03 4.02e-02 7/45 IER3; FYN; GATA3; ZFP36L1; PPP2R5C; SLC9A3R1; PIK3IP1
GO:0050866 negative regulation of cell activation 3.31 1.34e-03 1.69e-02 9/58 XCL1; ID2; TIGIT; NDFIP1; FAM65B; IL2RA; CD9; LAG3; SOCS1
GO:0002521 leukocyte differentiation 3.27 2.52e-09 4.85e-07 31/202 TNFRSF18; LCK; JUN; CD2; FCER1G; ID2; ZFP36L2; ITGA4; CMTM7; RBPJ; LEF1; IL7R; PTGER4; CAMK4; CSF2; NDFIP1; CDK6; ITM2A; CD3G; IL2RA; GATA3; IFNG; ZFP36L1; BATF; SOCS1; EVI2B; CCL3; ADA; JUNB; LGALS1; SOD1
GO:0022407 regulation of cell-cell adhesion 3.26 1.98e-07 2.07e-05 24/157 LCK; XCL1; ITGA4; SELK; TIGIT; LEF1; IL7R; NDFIP1; FAM65B; FYN; CD44; IL2RA; GATA3; MAP3K8; ANK3; CD9; LAG3; IFNG; RGCC; SOCS1; PYCARD; ADA; TNFSF14; LGALS1
GO:0071706 tumor necrosis factor superfamily cytokine production 3.22 2.95e-03 3.09e-02 8/53 CD2; FCER1G; SELK; HSPB1; IFNG; PYCARD; CYBA; CCL3
GO:0042110 T cell activation 3.19 2.65e-09 4.85e-07 32/214 TNFRSF18; TNFRSF4; LCK; CD2; FCER1G; XCL1; ZFP36L2; CD8B; SELK; TIGIT; LEF1; IL7R; PTGER4; CAMK4; NDFIP1; FAM65B; FYN; CD3G; CRTAM; IL2RA; GATA3; MAP3K8; LAG3; IFNG; ZFP36L1; BATF; SOCS1; PYCARD; ADA; TNFSF14; LGALS1; SOD1
GO:0050727 regulation of inflammatory response 3.17 6.00e-05 1.69e-03 15/101 PARK7; FCER1G; XCL1; PTGER4; NDFIP1; BIRC3; IL2RA; GATA3; NFKBIA; PYCARD; CCL1; CCL3; CCL3L3; ADA; GPX4
GO:0048568 embryonic organ development 3.14 1.16e-04 2.57e-03 14/95 ID2; RBPJ; LEF1; CSF2; FAM65B; AHI1; RDH10; MICAL2; GATA3; ZFP36L1; SLC9A3R1; ADA; JUNB; SOD1
GO:0097191 extrinsic apoptotic signaling pathway 3.14 1.16e-04 2.57e-03 14/95 TNFRSF4; PARK7; LMNA; CFLAR; SIAH2; TNFSF10; CSF2; FYN; TRAF1; IFNG; PYCARD; PMAIP1; BCL2L1; CD70
GO:0042063 gliogenesis 3.13 6.53e-04 9.77e-03 11/75 PHGDH; ID2; BIN1; LEF1; CDK6; BNIP3; CD9; SYNE2; IDH2; CCL3; SOD1
GO:0033002 muscle cell proliferation 3.10 3.74e-03 3.66e-02 8/55 JUN; ID2; CFLAR; RBPJ; NAMPT; IFNG; CYBA; PTGIR
GO:0051047 positive regulation of secretion 3.10 2.58e-05 9.94e-04 17/117 TNFRSF4; CD58; CD2; FCER1G; GLUL; SPTBN1; SELK; PTGER4; CRTAM; GATA3; IFNG; RGCC; PYCARD; CYBA; CCL1; CCL3; KCNN4
GO:0007159 leukocyte cell-cell adhesion 3.05 2.14e-06 1.31e-04 22/154 LCK; XCL1; SELL; ITGA4; SELK; TIGIT; IL7R; NDFIP1; FAM65B; FYN; CD44; IL2RA; GATA3; MAP3K8; LAG3; IFNG; SELPLG; SOCS1; PYCARD; ADA; TNFSF14; LGALS1
GO:0001818 negative regulation of cytokine production 3.05 1.63e-04 3.40e-03 14/98 TNFRSF4; XCL1; REL; TIGIT; LEF1; PTGER4; NDFIP1; GATA3; SRGN; LAG3; IFNG; RGCC; PYCARD; KLF2
GO:0007389 pattern specification process 3.05 2.43e-03 2.61e-02 9/63 BTG2; ZEB2; BHLHE40; RBPJ; LEF1; AHI1; MICAL2; EED; KIF3B
GO:0035821 modification of morphology or physiology of other organism 3.05 2.43e-03 2.61e-02 9/63 JUN; GNLY; LEF1; SERPINB9; IFNG; CCL3; CCL4L2; BCL2L1; RRP1B
GO:0050920 regulation of chemotaxis 3.05 4.19e-03 3.89e-02 8/56 XCL2; XCL1; FAM65B; HSPB1; CCL1; CCL3; CCL4L2; TNFSF14
GO:0048511 rhythmic process 3.01 5.34e-04 8.69e-03 12/85 JUN; ID2; BHLHE40; SIAH2; CSF2; NAMPT; PRKCDBP; CREM; NFKB2; ADA; JUND; ATF5
GO:0001819 positive regulation of cytokine production 2.99 1.73e-06 1.15e-04 23/164 PARK7; CD58; CD2; FCER1G; XCL1; SPTBN1; SELK; TIGIT; PTGER4; CSF2; LTB; HSPB1; BIRC3; CRTAM; GATA3; NFKB2; IFNG; RGCC; PYCARD; CYBA; CCL1; CCL3; SOD1
GO:0045785 positive regulation of cell adhesion 2.97 5.72e-06 2.79e-04 21/151 TNFRSF18; LCK; S100A10; XCL1; ITGA4; SELK; IL7R; FYN; CDK6; NINJ1; CD44; IL2RA; GATA3; MAP3K8; ANK3; IFNG; SOCS1; PYCARD; ADA; TNFSF14; LGALS1
GO:0002449 lymphocyte mediated immunity 2.93 2.51e-04 4.71e-03 14/102 PRDX1; FCER1G; XCL1; LYST; IL7R; NDFIP1; SERPINB9; CRTAM; GATA3; LAG3; KLRD1; GZMB; BATF; CTSH
GO:0002285 lymphocyte activation involved in immune response 2.92 1.95e-03 2.20e-02 10/73 FCER1G; LEF1; PTGER4; NDFIP1; ITM2A; GATA3; IFNG; BATF; ADA; LGALS1
GO:0003013 circulatory system process 2.91 7.35e-04 1.08e-02 12/88 XCL2; ID2; BIN1; ITPR1; HRH2; FYN; NAMPT; CYBA; MAP2K3; SCPEP1; ADA; SOD1
GO:1903706 regulation of hemopoiesis 2.87 3.60e-06 2.03e-04 23/171 TNFRSF18; JUN; CD2; ID2; ZFP36L2; LEF1; IL7R; CAMK4; CSF2; NDFIP1; CDK6; IL2RA; GATA3; IFNG; NFKBIA; ZFP36L1; KLF13; SOCS1; EVI2B; CCL3; ADA; LGALS1; SOD1
GO:0052547 regulation of peptidase activity 2.85 1.07e-05 4.55e-04 21/157 PARK7; LCK; BIN1; CFLAR; SIAH2; TNFSF10; LEF1; CAST; TNFAIP8; SERPINB9; PSMB8; FYN; CD44; BIRC3; SORL1; PSME1; CTSH; PYCARD; HERPUD1; PMAIP1; TNFSF14
GO:0048872 homeostasis of number of cells 2.84 1.29e-04 2.78e-03 16/120 TNFRSF4; PRDX1; FCER1G; ID2; IL7R; SFXN1; CDK6; IL2RA; GATA3; ZFP36L1; KLF13; PMAIP1; ADA; TNFSF14; KLF2; SOD1
GO:0019932 second-messenger-mediated signaling 2.84 9.02e-04 1.22e-02 12/90 RAMP1; ITPR1; SELK; PTGER4; CXCR3; CCL3; CCL4L2; SLC9A3R1; ADA; S1PR4; ADGRE5; PTGIR
GO:0051271 negative regulation of cellular component movement 2.81 2.65e-03 2.81e-02 10/76 BIN1; PTGER4; FAM65B; GATA3; CD9; ARHGDIB; RGCC; IDH2; SLC9A3R1; ADA
GO:0007162 negative regulation of cell adhesion 2.79 1.71e-03 2.05e-02 11/84 XCL1; TIGIT; NDFIP1; FAM65B; IL2RA; CD9; LAG3; ARHGDIB; RGCC; SOCS1; LGALS1
GO:0072507 divalent inorganic cation homeostasis 2.79 1.01e-04 2.48e-03 17/130 LCK; XCL1; ITPR1; SELK; CCDC109B; PTGER4; FYN; CXCR3; ANK3; BNIP3; MT2A; HERPUD1; CYBA; CCL1; CCL3; S1PR4; PTGIR
GO:2000147 positive regulation of cell motility 2.77 2.71e-05 9.94e-04 20/154 TNFRSF18; JUN; XCL2; XCL1; ITGA4; SELK; LEF1; FAM65B; HSPB1; FAM89B; GATA3; IFNG; SYNE2; CTSH; PYCARD; MAP2K3; CCL1; CCL3; CCL4L2; TNFSF14
GO:0034341 response to interferon-gamma 2.76 1.88e-03 2.19e-02 11/85 CD58; XCL2; XCL1; CD44; IFNG; SOCS1; MT2A; CCL1; CCL3; CCL3L3; CCL4L2
GO:0002694 regulation of leukocyte activation 2.75 1.09e-06 8.89e-05 27/209 TNFRSF18; TNFRSF4; LCK; CD2; FCER1G; XCL1; ID2; ZFP36L2; SELK; TIGIT; IL7R; CAMK4; NDFIP1; FAM65B; FYN; IL2RA; GATA3; MAP3K8; LAG3; IFNG; ZFP36L1; SOCS1; PYCARD; ADA; TNFSF14; LGALS1; SOD1
GO:0042113 B cell activation 2.74 5.04e-04 8.39e-03 14/109 TNFRSF4; ID2; ZFP36L2; ITGA4; CMTM7; RBPJ; LEF1; IL7R; NDFIP1; ITM2A; ZFP36L1; BATF; ADA; LGALS1
GO:0009615 response to virus 2.74 5.10e-05 1.58e-03 19/148 XCL1; LYST; SELK; SERINC5; HMGA1; HSPB1; CDK6; BIRC3; IL2RA; GATA3; BNIP3; IFNG; ISG20; PYCARD; CCL4L2; PMAIP1; BCL2L1; SAMHD1; RRP1B
GO:0010038 response to metal ion 2.69 6.07e-04 9.47e-03 14/111 PARK7; JUN; TXNIP; ID2; AQP3; RASGRP2; ANK3; BNIP3; ALOX5AP; MT2A; ATP5D; JUNB; JUND; SOD1
GO:0002683 negative regulation of immune system process 2.68 4.34e-05 1.45e-03 20/159 TNFRSF4; FCER1G; XCL1; ID2; TIGIT; IL7R; PTGER4; NDFIP1; SERPINB9; FAM65B; CDK6; IL2RA; LAG3; NFKBIA; ZFP36L1; KLF13; SOCS1; CCL3; SAMHD1; ADA
GO:0002440 production of molecular mediator of immune response 2.63 4.25e-03 3.89e-02 10/81 TNFRSF4; FCER1G; XCL1; IL7R; CAMK4; NDFIP1; ITM2A; GATA3; BATF; SAMHD1
GO:0050867 positive regulation of cell activation 2.55 3.02e-04 5.53e-03 17/142 TNFRSF4; LCK; CD2; FCER1G; XCL1; SELK; IL7R; FYN; IL2RA; GATA3; MAP3K8; IFNG; SOCS1; PYCARD; ADA; TNFSF14; LGALS1
GO:0030099 myeloid cell differentiation 2.51 1.13e-04 2.57e-03 20/170 JUN; FCER1G; ID2; RBPJ; LEF1; CAMK4; CSF2; NDFIP1; SFXN1; CDK6; GATA3; IFNG; NFKBIA; ZFP36L1; BATF; KLF13; EVI2B; CCL3; JUNB; KLF2
GO:0050673 epithelial cell proliferation 2.50 4.20e-03 3.89e-02 11/94 JUN; GLUL; ID2; ITGA4; CFLAR; CDK6; MTSS1; GATA3; RGCC; ZFP36L1; CYBA
GO:0043087 regulation of GTPase activity 2.47 2.06e-04 4.09e-03 19/164 JUN; S100A10; XCL2; XCL1; RGS1; SNX9; TAGAP; RASGRP2; RGS10; ARHGDIB; PYCARD; ACAP1; CCL1; CCL3; CCL3L3; CCL4L2; STMN3; SOD1; RRP1B
GO:2001233 regulation of apoptotic signaling pathway 2.47 6.50e-05 1.76e-03 22/190 TNFRSF4; PARK7; LCK; LMNA; CFLAR; SIAH2; TNFSF10; CSF2; FYN; HSPB1; TRAF1; CD44; BNIP3; ERP29; GZMB; CTSH; PYCARD; HERPUD1; SLC9A3R1; PMAIP1; BCL2L1; SOD1
GO:0002250 adaptive immune response 2.47 4.56e-04 7.78e-03 17/147 FCER1G; XCL1; CD8B; LEF1; IL7R; CAMK4; NDFIP1; FYN; CD3G; CRTAM; GATA3; NFKB2; IFNG; BATF; CTSH; PYCARD; ADA
GO:0001667 ameboidal-type cell migration 2.39 4.03e-03 3.84e-02 12/107 JUN; GLUL; ZEB2; ITGA4; HSPB1; GATA3; ARHGDIB; IFNG; RGCC; CTSH; CENPV; MAP2K3
GO:0071496 cellular response to external stimulus 2.37 2.13e-03 2.36e-02 14/126 JUN; GLUL; PTGER4; FAM65B; FYN; NAMPT; AQP3; BNIP3; CYBA; PMAIP1; CNN2; AES; TNFSF14; SOD1
GO:0072511 divalent inorganic cation transport 2.37 3.04e-03 3.14e-02 13/117 LCK; XCL1; BIN1; RAMP1; ITPR1; SELK; CCDC109B; FYN; SARAF; CYBA; CCL3; CCL4L2; KCNN4
GO:0002009 morphogenesis of an epithelium 2.35 4.69e-03 4.14e-02 12/109 LMO4; ZEB2; RBPJ; LEF1; AHI1; RDH10; MTSS1; MICAL2; CD44; GATA3; CTSH; SLC9A3R1
GO:1904951 positive regulation of establishment of protein localization 2.34 2.01e-04 4.09e-03 21/191 TNFRSF4; CD58; CD2; GLUL; SPTBN1; CAMK1; SELK; PTGER4; FYN; SORL1; CRTAM; GATA3; ANK3; IFNG; RGCC; GZMB; PYCARD; CCL1; CCL3; PMAIP1; KCNN4
GO:0001525 angiogenesis 2.31 3.80e-03 3.66e-02 13/120 JUN; SH2D2A; GLUL; RAMP1; RBPJ; LEF1; HSPB1; SRPK2; CXCR3; RGCC; PKM; CTSH; KLF2
GO:0045861 negative regulation of proteolysis 2.31 3.80e-03 3.66e-02 13/120 PARK7; BIN1; CFLAR; SIAH2; LEF1; CAST; TNFAIP8; SERPINB9; CD44; BIRC3; SORL1; HERPUD1; TNFSF14
GO:0070661 leukocyte proliferation 2.31 5.44e-03 4.68e-02 12/111 TNFRSF4; XCL1; SELK; LEF1; IL7R; NDFIP1; FYN; CRTAM; IL2RA; PYCARD; ADA; TNFSF14
GO:0051051 negative regulation of transport 2.29 1.50e-03 1.86e-02 16/149 TNFRSF4; PARK7; BIN1; PTGER4; NDFIP1; MDFIC; RAB11FIP1; ANK3; SRGN; ERP29; RGCC; NDFIP2; IDH2; SLC9A3R1; ADA; PIM3
GO:0098542 defense response to other organism 2.24 1.85e-03 2.19e-02 16/152 FCER1G; LYST; GNLY; SELK; RBPJ; SERINC5; BIRC3; IL2RA; BNIP3; IFNG; BATF; ISG20; PYCARD; CYBA; PMAIP1; SAMHD1
GO:0009636 response to toxic substance 2.22 1.11e-03 1.46e-02 18/173 PARK7; PRDX1; JUN; TXNIP; FYN; GATA3; RGS10; BNIP3; ALOX5AP; MT2A; CCL3; CCL4L2; BCL2L1; ADA; GPX4; KLF2; SOD1; MT-ND5
GO:0051098 regulation of binding 2.20 1.70e-03 2.05e-02 17/165 PARK7; EPB41; JUN; S100A10; PYHIN1; ID2; ITGA4; CAMK1; LEF1; FAM65B; SORL1; GATA3; IFNG; NFKBIA; HERPUD1; TRAF4; AES
GO:0043900 regulation of multi-organism process 2.17 1.94e-03 2.20e-02 17/167 JUN; SELK; LEF1; SRPK2; MDFIC; BIRC3; IL2RA; ARHGDIB; IFNG; ISG20; PYCARD; CYBA; CCL3; CCL4L2; ADA; LGALS1; RRP1B
GO:0070482 response to oxygen levels 2.15 5.25e-03 4.59e-02 14/139 LMNA; CFLAR; ITPR1; RBPJ; NAMPT; AQP3; BNIP3; RGCC; ZFP36L1; PKM; CYBA; PMAIP1; ADA; MT-ND5
CD5 : 74 significant GO terms
GeneSet description enrichRatio pValue FDR GeneRatio geneSymbols
GO:0001773 myeloid dendritic cell activation 6.98 2.50e-05 0.001833 7/16 CD2; RBPJ; CAMK4; CSF2; HMGB1; BATF; PYCARD
GO:0044091 membrane biogenesis 6.64 5.16e-04 0.014017 5/12 S100A10; SPTBN1; RFTN1; ANK3; ANXA2
GO:0042490 mechanoreceptor differentiation 5.80 3.52e-03 0.038037 4/11 RBPJ; FAM65B; SLC9A3R1; SOD1
GO:1904019 epithelial cell apoptotic process 5.69 3.89e-06 0.000571 10/28 E2F2; DNMT3A; ITGA4; CFLAR; CAST; RGCC; ZFP36L1; ARRB2; BCL2L1; ZFP36
GO:0140253 cell-cell fusion 5.63 3.98e-04 0.012433 6/17 CD53; CAPN2; CFLAR; CAMK1; FAM65B; TNFSF14
GO:0006949 syncytium formation 5.31 5.66e-04 0.014122 6/18 CD53; CAPN2; CFLAR; CAMK1; FAM65B; TNFSF14
GO:0031579 membrane raft organization 5.31 5.03e-03 0.047841 4/12 CD2; S100A10; RFTN1; ANXA2
GO:0032613 interleukin-10 production 4.98 2.31e-03 0.030554 5/16 FCER1G; XCL1; TIGIT; HMGB1; PYCARD
GO:0032615 interleukin-12 production 4.20 5.26e-03 0.048851 5/19 TIGIT; LTB; IFNG; HMGB1; ARRB2
GO:0007187 G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger 3.99 6.11e-04 0.014440 8/32 RGS1; RAMP1; PTGER4; HRH2; SLC9A3R1; S1PR4; ADGRE5; PTGIR
GO:0051341 regulation of oxidoreductase activity 3.60 2.54e-03 0.030995 7/31 PARK7; COX17; GZMA; IFNG; CALM1; CYBA; NOSIP
GO:0009612 response to mechanical stimulus 3.54 2.47e-05 0.001833 14/63 JUN; TXNIP; BTG2; CASP8; PTGER4; FAM65B; FYN; BNIP3; NFKBIA; CYBA; CNN2; TNFSF14; JUNB; JUND
GO:0001906 cell killing 3.36 1.64e-04 0.006334 12/57 PRDX1; XCL1; LYST; IL7R; SERPINB9; NCR3; HSP90AB1; CRTAM; IFNG; CTSH; CORO1A; ARRB2
GO:0032635 interleukin-6 production 3.36 2.04e-03 0.030102 8/38 FCER1G; CAPN2; SELK; HMGB1; PYCARD; CYBA; ARRB2; KLF2
GO:0050663 cytokine secretion 3.29 1.09e-04 0.005523 13/63 TNFRSF4; CD2; SPTBN1; SELK; RBPJ; PTGER4; CRTAM; SRGN; HMGB1; RGCC; SOCS1; PYCARD; CCL1
GO:0034612 response to tumor necrosis factor 3.29 1.58e-06 0.000571 20/97 TNFRSF18; TNFRSF4; TNFRSF9; XCL2; XCL1; ZFP36L2; CASP8; LTB; TRAF1; BIRC3; CD27; NFKBIA; ZFP36L1; PYCARD; CYBA; CCL1; CD70; TNFSF14; KLF2; ZFP36
GO:0015850 organic hydroxy compound transport 3.19 1.59e-03 0.026049 9/45 PARK7; FCER1G; NCOA1; MFSD10; AQP3; NFKBIA; NPC2; ANXA2; GRAMD1A
GO:0008277 regulation of G protein-coupled receptor signaling pathway 3.19 5.23e-03 0.048851 7/35 RGS1; RAMP1; GRK6; RGS3; NMT2; CALM1; ARRB2
GO:0038061 NIK/NF-kappaB signaling 3.13 5.78e-04 0.014122 11/56 PRDX1; REL; BIRC3; NFKB2; CD27; HDAC7; HMGB1; NFKBIA; NFAT5; TRAF4; TNFSF14
GO:0071706 tumor necrosis factor superfamily cytokine production 3.01 1.42e-03 0.024735 10/53 CD2; FCER1G; SELK; HSPB1; IFNG; HMGB1; PYCARD; CYBA; ARRB2; ZFP36
GO:0001525 angiogenesis 2.92 3.77e-06 0.000571 22/120 E2F2; JUN; SH2D2A; GLUL; CYP1B1; RAMP1; RBPJ; HPSE; ADTRP; HSPB1; SRPK2; CXCR3; PDE3B; HDAC7; HMGB1; RGCC; WARS; ANXA2; PKM; CTSH; RNF213; KLF2
GO:0070371 ERK1 and ERK2 cascade 2.92 1.40e-04 0.006025 15/82 JUN; XCL2; XCL1; ZFP36L2; CFLAR; PTGER4; DUSP4; PRKCDBP; HMGB1; ZFP36L1; CTSH; PYCARD; ARRB2; CCL1; SLC9A3R1
GO:0097191 extrinsic apoptotic signaling pathway 2.85 6.74e-05 0.003800 17/95 TNFRSF4; PARK7; LMNA; HTRA2; CFLAR; CASP8; SIAH2; TNFSF10; CSF2; FYN; TRAF1; CD27; IFNG; PYCARD; PMAIP1; BCL2L1; CD70
GO:0050900 leukocyte migration 2.85 5.76e-06 0.000703 22/123 TNFRSF18; LCK; CD2; FCER1G; XCL2; XCL1; SELL; LYST; ITGA4; SELK; PTGER4; ADTRP; FAM65B; FYN; CXCR3; DOK2; SELPLG; HMGB1; CORO1A; PYCARD; CCL1; TNFSF14
GO:0043062 extracellular structure organization 2.85 2.19e-03 0.030159 10/56 CYP1B1; DPP4; ITGA4; CFLAR; ADTRP; FSCN1; NFKB2; RGCC; ANXA2; COL6A2
GO:0002791 regulation of peptide secretion 2.77 3.58e-06 0.000571 24/138 TNFRSF4; CD2; GLUL; SPTBN1; DPP4; ITPR1; SELK; PTGER4; ADTRP; HMGN3; SLC25A5; RAB11FIP1; PHPT1; CRTAM; SRGN; IFNG; ERP29; HMGB1; RGCC; SOCS1; PYCARD; CCL1; KCNN4; PIM3
GO:0060326 cell chemotaxis 2.73 7.60e-04 0.017160 13/76 FCER1G; XCL2; XCL1; LYST; FAM65B; HSPB1; CXCR3; BIN2; HMGB1; CORO1A; ARRB2; CCL1; TNFSF14
GO:0072507 divalent inorganic cation homeostasis 2.70 1.45e-05 0.001522 22/130 LCK; XCL1; ITPR1; SELK; CCDC109B; PTGER4; FYN; P2RY8; CXCR3; ANK3; BNIP3; HMGB1; TPT1; CALM1; ANXA2; CORO1A; MT2A; HERPUD1; CYBA; CCL1; S1PR4; PTGIR
GO:1901342 regulation of vasculature development 2.69 8.64e-04 0.017594 13/77 E2F2; GLUL; CYP1B1; CFLAR; HSPB1; PDE3B; HDAC7; HMGB1; RGCC; WARS; PKM; CTSH; KLF2
GO:0008544 epidermis development 2.61 4.20e-03 0.042713 10/61 TXNIP; RBPJ; HPSE; FAM65B; AQP3; KRT7; ZFP36L1; SLC9A3R1; ZFP36; SOD1
GO:1901654 response to ketone 2.61 4.20e-03 0.042713 10/61 PARK7; TXNIP; CFLAR; PTGER4; NR3C1; DDIT4; CALM1; CYBA; BCL2L1; KLF2
GO:0008637 apoptotic mitochondrial changes 2.58 3.03e-03 0.035245 11/68 JUN; LMNA; CASP8; TNFSF10; SLC25A5; YWHAZ; BNIP3; PYCARD; ARRB2; PMAIP1; BCL2L1
GO:0043491 protein kinase B signaling 2.58 3.03e-03 0.035245 11/68 PARK7; LCK; TRAT1; HPSE; ADTRP; HSP90AB1; FYN; PRKCDBP; ZFP36L1; ARRB2; SLC9A3R1
GO:0097305 response to alcohol 2.55 2.19e-03 0.030159 12/75 DNMT3A; CASP8; PTGER4; FYN; CD27; CALM1; CYBA; BCL2L1; RGS19; KLF2; GRAMD1A; SOD1
GO:0032970 regulation of actin filament-based process 2.55 1.27e-04 0.005822 19/119 CAPZB; S100A10; SPTBN1; TMSB10; BIN1; PTGER4; ABRACL; FSCN1; PHPT1; RDX; ADD3; ARHGDIB; RGCC; EVL; CORO1A; PYCARD; ARHGDIA; DSTN; CNN2
GO:1904950 negative regulation of establishment of protein localization 2.54 3.41e-03 0.038037 11/69 TNFRSF4; PARK7; PTGER4; ADTRP; MDFIC; RAB11FIP1; SRGN; ERP29; RGCC; NDFIP2; PIM3
GO:0071241 cellular response to inorganic substance 2.51 3.82e-03 0.040038 11/70 JUN; ID2; CFLAR; RASGRP2; ANK3; BNIP3; HVCN1; MT2A; JUNB; JUND; SOD1
GO:0090130 tissue migration 2.50 1.77e-03 0.027593 13/83 JUN; GLUL; CYP1B1; DPP4; ADTRP; HSPB1; HDAC7; IFNG; HMGB1; RGCC; EVL; CTSH; MAP2K3
GO:0007162 negative regulation of cell adhesion 2.47 1.98e-03 0.030102 13/84 XCL1; CYP1B1; TIGIT; ADTRP; FAM65B; PDE3B; RDX; CD9; ARHGDIB; HMGB1; RGCC; SOCS1; ARHGDIA
GO:0010038 response to metal ion 2.44 4.77e-04 0.013440 17/111 PARK7; JUN; TXNIP; ID2; DNMT3A; CASP8; AQP3; RASGRP2; ANK3; BNIP3; HVCN1; CALM1; MT2A; ATP5D; JUNB; JUND; SOD1
GO:0001818 negative regulation of cytokine production 2.44 1.02e-03 0.019759 15/98 TNFRSF4; XCL1; REL; TIGIT; PTGER4; HSP90AB1; SRGN; HDAC7; IFNG; HMGB1; RGCC; PYCARD; ARRB2; KLF2; ZFP36
GO:0022407 regulation of cell-cell adhesion 2.44 3.45e-05 0.002110 24/157 LCK; XCL1; DPP4; ITGA4; SELK; TIGIT; IL7R; ADTRP; FAM65B; FYN; RDX; MAP3K8; ANK3; CD9; CD27; IFNG; HMGB1; RGCC; SOCS1; CORO1A; PYCARD; NFAT5; TNFSF14; GRAP2
GO:0052547 regulation of peptidase activity 2.44 3.45e-05 0.002110 24/157 PARK7; LCK; HTRA2; BIN1; CFLAR; CASP8; SIAH2; TNFSF10; CAST; TNFAIP8; SERPINB9; PSMB8; FYN; BIRC3; SORL1; CD27; HMGB1; PSME1; CTSH; PYCARD; HERPUD1; ARRB2; PMAIP1; TNFSF14
GO:0050817 coagulation 2.42 1.14e-03 0.021429 15/99 CAPZB; LCK; FCER1G; H3F3A; ITPR1; HPSE; ADTRP; FYN; HSPB1; YWHAZ; CD9; ANXA2; ARRB2; ACTG1; MYL12A
GO:0048872 homeostasis of number of cells 2.39 4.24e-04 0.012433 18/120 TNFRSF4; PRDX1; FCER1G; ID2; LYAR; IL7R; SFXN1; CDK6; RPS24; HMGB1; ZFP36L1; KLF13; CORO1A; PMAIP1; TNFSF14; KLF2; ZFP36; SOD1
GO:0042110 T cell activation 2.38 2.65e-06 0.000571 32/214 TNFRSF18; TNFRSF4; LCK; CD2; FCER1G; XCL1; ZFP36L2; CD8B; DPP4; CASP8; SELK; TIGIT; IL7R; PTGER4; CAMK4; FAM65B; CCND3; FYN; CD3G; CRTAM; MAP3K8; CD27; IFNG; HMGB1; ZFP36L1; BATF; SOCS1; CORO1A; PYCARD; TNFSF14; GRAP2; SOD1
GO:0001667 ameboidal-type cell migration 2.38 9.10e-04 0.018035 16/107 JUN; GLUL; CYP1B1; DPP4; ITGA4; ADTRP; HSPB1; ARHGDIB; HDAC7; IFNG; HMGB1; RGCC; EVL; CTSH; CENPV; MAP2K3
GO:0002449 lymphocyte mediated immunity 2.34 1.56e-03 0.026049 15/102 PRDX1; FCER1G; XCL1; LYST; RFTN1; IL7R; SERPINB9; NCR3; CRTAM; CD27; HMGB1; BATF; CTSH; CORO1A; ARRB2
GO:0045785 positive regulation of cell adhesion 2.32 1.53e-04 0.006231 22/151 TNFRSF18; LCK; S100A10; XCL1; DPP4; ITGA4; SELK; IL7R; FYN; CDK6; NINJ1; MAP3K8; ANK3; CD27; IFNG; HMGB1; SOCS1; CORO1A; PYCARD; NFAT5; TNFSF14; GRAP2
GO:0019932 second-messenger-mediated signaling 2.30 3.70e-03 0.039280 13/90 RAMP1; ITPR1; SELK; TRAT1; PTGER4; CXCR3; PDE3B; CALM1; NFAT5; SLC9A3R1; S1PR4; ADGRE5; PTGIR
GO:0002521 leukocyte differentiation 2.29 1.80e-05 0.001647 29/202 TNFRSF18; LCK; JUN; CD2; FCER1G; ID2; ZFP36L2; ITGA4; CASP8; CMTM7; RBPJ; IL7R; PTGER4; CAMK4; CSF2; CDK6; ITM2A; CD3G; CD27; IFNG; HMGB1; ZFP36L1; BATF; ANXA2; SOCS1; EVI2B; JUNB; MFNG; SOD1
GO:0007159 leukocyte cell-cell adhesion 2.28 2.05e-04 0.007152 22/154 LCK; XCL1; SELL; DPP4; ITGA4; SELK; TIGIT; IL7R; ADTRP; FAM65B; FYN; MAP3K8; CD27; IFNG; SELPLG; HMGB1; SOCS1; CORO1A; PYCARD; NFAT5; TNFSF14; GRAP2
GO:0071496 cellular response to external stimulus 2.28 7.73e-04 0.017160 18/126 JUN; GLUL; NCOA1; CASP8; PTGER4; FAM65B; PIM1; FYN; UPP1; NAMPT; AQP3; BNIP3; CYBA; PMAIP1; CNN2; AES; TNFSF14; SOD1
GO:0001819 positive regulation of cytokine production 2.24 1.95e-04 0.007144 23/164 PARK7; CD2; FCER1G; XCL1; CYP1B1; SPTBN1; SELK; TIGIT; HPSE; PTGER4; CSF2; LTB; HSPB1; BIRC3; CRTAM; NFKB2; IFNG; HMGB1; RGCC; PYCARD; CYBA; CCL1; SOD1
GO:0002237 response to molecule of bacterial origin 2.23 3.53e-03 0.038037 14/100 JUN; CAPN2; CASP8; PTGER4; CSF2; VIM; NFKB2; HMGB1; NFKBIA; PYCARD; JUNB; JUND; ZFP36; PTGIR
GO:0072593 reactive oxygen species metabolic process 2.23 3.53e-03 0.038037 14/100 PARK7; PRDX1; CYP1B1; CFLAR; HSP90AB1; FYN; STK17A; DDIT4; BNIP3; IFNG; CYBA; PMAIP1; KLF2; SOD1
GO:0042692 muscle cell differentiation 2.23 4.93e-03 0.047539 13/93 CD53; LMNA; CAPN2; H3F3A; BIN1; CFLAR; CAMK1; RBPJ; FAM65B; TMEM204; ARRB2; ACTG1; TNFSF14
GO:2001233 regulation of apoptotic signaling pathway 2.18 1.13e-04 0.005523 26/190 TNFRSF4; PARK7; LCK; LMNA; HTRA2; CFLAR; CASP8; SIAH2; TNFSF10; CSF2; FYN; HSPB1; SLC25A5; YWHAZ; TRAF1; BNIP3; ERP29; TPT1; CTSH; PYCARD; HERPUD1; ARRB2; SLC9A3R1; PMAIP1; BCL2L1; SOD1
GO:0051047 positive regulation of secretion 2.18 2.38e-03 0.030554 16/117 TNFRSF4; CD2; FCER1G; GLUL; SPTBN1; SELK; PTGER4; PHPT1; CRTAM; IFNG; HMGB1; RGCC; PYCARD; CYBA; CCL1; KCNN4
GO:0072511 divalent inorganic cation transport 2.18 2.38e-03 0.030554 16/117 LCK; XCL1; BIN1; RAMP1; ITPR1; SELK; CCDC109B; FYN; SARAF; TPT1; CALM1; ANXA2; CORO1A; CYBA; ARRB2; KCNN4
GO:2000147 positive regulation of cell motility 2.17 5.44e-04 0.014122 21/154 TNFRSF18; JUN; XCL2; XCL1; ITGA4; SELK; FAM65B; HSPB1; PHPT1; FAM89B; RDX; HDAC7; IFNG; HMGB1; SYNE2; CTSH; CORO1A; PYCARD; MAP2K3; CCL1; TNFSF14
GO:0070997 neuron death 2.17 1.34e-03 0.024212 18/132 PARK7; JUN; BTG2; CAPN2; REL; HTRA2; CASP8; HSP90AB1; FYN; SRPK2; NAMPT; SORL1; DDIT4; BNIP3; CORO1A; ARRB2; BCL2L1; SOD1
GO:0050878 regulation of body fluid levels 2.14 1.60e-03 0.026049 18/134 CAPZB; LCK; FCER1G; H3F3A; ITPR1; HPSE; ADTRP; FYN; HSPB1; YWHAZ; AQP3; CD9; ANXA2; CYBA; ARRB2; ACTG1; MYL12A; KCNN4
GO:0002683 negative regulation of immune system process 2.11 8.35e-04 0.017484 21/159 TNFRSF4; FCER1G; XCL1; ID2; TIGIT; IL7R; PTGER4; SERPINB9; ADTRP; FAM65B; LST1; CDK6; PHPT1; HMGB1; NFKBIA; ZFP36L1; KLF13; SOCS1; ARRB2; SAMHD1; ZFP36
GO:0070482 response to oxygen levels 2.06 2.43e-03 0.030554 18/139 LMNA; CAPN2; DNMT3A; DPP4; CFLAR; ITPR1; RBPJ; NAMPT; AQP3; ATP6V1G1; DDIT4; BNIP3; RGCC; ZFP36L1; PKM; CYBA; PMAIP1; MT-ND5
GO:0030099 myeloid cell differentiation 2.06 8.34e-04 0.017484 22/170 JUN; FCER1G; H3F3A; ID2; CASP8; LYAR; RBPJ; CAMK4; CSF2; SFXN1; CDK6; IFNG; HMGB1; NFKBIA; ZFP36L1; BATF; KLF13; ANXA2; EVI2B; JUNB; KLF2; ZFP36
GO:0002694 regulation of leukocyte activation 2.06 2.23e-04 0.007429 27/209 TNFRSF18; TNFRSF4; LCK; CD2; FCER1G; XCL1; ID2; ZFP36L2; DPP4; SELK; TIGIT; IL7R; CAMK4; FAM65B; LST1; FYN; MAP3K8; CD27; IFNG; HMGB1; ZFP36L1; SOCS1; CORO1A; PYCARD; TNFSF14; GRAP2; SOD1
GO:0009615 response to virus 2.05 2.05e-03 0.030102 19/148 XCL1; LYST; SELK; SERINC5; HMGA1; HSPB1; CDK6; BIRC3; DDIT4; BNIP3; IFNG; TPT1; NPC2; ISG20; PYCARD; PMAIP1; BCL2L1; SAMHD1; RRP1B
GO:0035690 cellular response to drug 2.04 4.67e-03 0.045669 16/125 PARK7; NCOA1; DNMT3A; CYP1B1; RNF149; CFLAR; NR3C1; HSP90AB1; FYN; VIM; DDIT4; BNIP3; MT2A; CYBA; KLF2; SOD1
GO:0046677 response to antibiotic 2.04 4.67e-03 0.045669 16/125 PARK7; JUN; TXNIP; CAPN2; DNMT3A; CYP1B1; CASP8; FYN; BNIP3; CD27; RPL23; BCL2L1; RGS19; KLF2; SOD1; MT-ND5
GO:0051051 negative regulation of transport 2.03 2.22e-03 0.030159 19/149 TNFRSF4; PARK7; BIN1; TRAT1; PTGER4; ADTRP; MDFIC; SLC25A5; RAB11FIP1; ANK3; SRGN; ERP29; HMGB1; RGCC; NDFIP2; CALM1; CORO1A; SLC9A3R1; PIM3
GO:0051098 regulation of binding 2.03 1.35e-03 0.024212 21/165 PARK7; EPB41; JUN; S100A10; ID2; ITGA4; CAMK1; GZMA; FAM65B; HSP90AB1; SORL1; IFNG; HMGB1; NFKBIA; CALM1; ANXA2; HERPUD1; ARRB2; TRAF4; AES; MFNG
GO:0050867 positive regulation of cell activation 2.02 3.08e-03 0.035245 18/142 TNFRSF4; LCK; CD2; FCER1G; XCL1; DPP4; SELK; IL7R; FYN; MAP3K8; CD27; IFNG; HMGB1; SOCS1; CORO1A; PYCARD; TNFSF14; GRAP2
GO:1902532 negative regulation of intracellular signal transduction 2.01 4.23e-04 0.012433 26/206 PARK7; HTRA2; DUSP2; RNF149; CASP8; ITPR1; FAM65B; STK38; HSPB1; DUSP4; RGS3; PRKCDBP; PDE3B; SORL1; DDIT4; HDAC7; TPT1; CALM1; SOCS1; PYCARD; HERPUD1; ARRB2; SLC9A3R1; BCL2L1; STMN3; PIK3IP1
LCP2 : 132 significant GO terms
GeneSet description enrichRatio pValue FDR GeneRatio geneSymbols
GO:0001773 myeloid dendritic cell activation 6.19 4.60e-07 1.40e-05 10/16 CD2; SLAMF1; BATF3; RBPJ; CAMK4; CSF2; BATF; PYCARD; TGFB1; RELB
GO:0034113 heterotypic cell-cell adhesion 6.19 4.60e-07 1.40e-05 10/16 LCK; CD2; PTPRC; ITGA4; CD47; FLOT1; PERP; ITGB1; ITGB7; ITGB2
GO:0042490 mechanoreceptor differentiation 5.41 3.04e-04 2.51e-03 6/11 SLC4A7; RBPJ; FAM65B; FGFR1; SLC9A3R1; SOD1
GO:0031579 membrane raft organization 4.95 5.57e-04 4.00e-03 6/12 CD2; S100A10; PTPRC; RFTN1; FLOT1; ANXA2
GO:0044091 membrane biogenesis 4.95 5.57e-04 4.00e-03 6/12 S100A10; SPTBN1; RFTN1; FLOT1; ANK3; ANXA2
GO:0032963 collagen metabolic process 4.69 3.70e-05 4.86e-04 9/19 CTSS; MYB; CTSD; VIM; ITGB1; C10orf54; HIF1A; ARRB2; TGFB1
GO:0140253 cell-cell fusion 4.66 1.09e-04 1.12e-03 8/17 CD53; PLEKHO1; CAPN2; CFLAR; CAMK1; FAM65B; FLOT1; TNFSF14
GO:0010573 vascular endothelial growth factor production 4.50 2.83e-03 1.64e-02 5/11 CYP1B1; HPSE; HIF1A; RORA; TGFB1
GO:0048645 animal organ formation 4.50 2.83e-03 1.64e-02 5/11 RBPJ; PIM1; CITED2; FGFR1; RDH10
GO:0006949 syncytium formation 4.40 1.78e-04 1.63e-03 8/18 CD53; PLEKHO1; CAPN2; CFLAR; CAMK1; FAM65B; FLOT1; TNFSF14
GO:0032613 interleukin-10 production 4.34 5.19e-04 3.81e-03 7/16 FCER1G; XCL1; CD47; TIGIT; C10orf54; PYCARD; LGALS9
GO:0032615 interleukin-12 production 4.17 2.81e-04 2.36e-03 8/19 SLAMF1; CD47; TIGIT; LTB; IFNG; ARRB2; LGALS9; CCR7
GO:0033627 cell adhesion mediated by integrin 4.17 2.81e-04 2.36e-03 8/19 CYP1B1; PDE3B; LPXN; ITGB1; PTPN6; ITGB7; CCL5; ITGB2
GO:0032620 interleukin-17 production 4.13 4.45e-03 2.30e-02 5/12 RFTN1; C10orf54; IFNG; CCL1; TGFB1
GO:0034405 response to fluid shear stress 4.13 4.45e-03 2.30e-02 5/12 CSF2; CITED2; MTSS1; KLF2; TGFB1
GO:0045730 respiratory burst 4.13 4.45e-03 2.30e-02 5/12 CD52; CD55; SELK; PGAM1; CYBA
GO:0055094 response to lipoprotein particle 4.13 4.45e-03 2.30e-02 5/12 FCER1G; ADTRP; CD81; ITGB1; ITGB2
GO:0071402 cellular response to lipoprotein particle stimulus 4.13 4.45e-03 2.30e-02 5/12 FCER1G; ADTRP; CD81; ITGB1; ITGB2
GO:0071604 transforming growth factor beta production 4.13 4.45e-03 2.30e-02 5/12 XCL1; HSP90AB1; MYB; HIF1A; LGALS9
GO:0097066 response to thyroid hormone 4.13 4.45e-03 2.30e-02 5/12 CTSS; ANXA5; RDX; ANXA2; EIF5A
GO:1990868 response to chemokine 3.96 4.27e-04 3.30e-03 8/20 XCL2; XCL1; FAM65B; CXCR3; HIF1A; CCL1; CCL5; CCR7
GO:0006968 cellular defense response 3.85 1.21e-03 7.97e-03 7/18 FCMR; GNLY; TRAT1; SH2D1A; ITGB1; PRF1; SPN
GO:0032612 interleukin-1 production 3.81 1.19e-04 1.22e-03 10/26 GBP5; IFI16; HSPB1; ANXA1; CASP1; CARD16; PYCARD; ARRB2; LGALS9; CCR7
GO:0007229 integrin-mediated signaling pathway 3.72 3.34e-05 4.53e-04 12/32 FCER1G; ITGA4; CD47; FYB; TIMP1; FLNA; ITGB1; ITGB7; CD63; LAT; ITGAL; ITGB2
GO:2001057 reactive nitrogen species metabolic process 3.72 3.30e-04 2.69e-03 9/24 ATP2B4; CYP1B1; CD47; AIF1; HSP90AB1; IFNG; RORA; KLF2; ITGB2
GO:0001906 cell killing 3.65 5.34e-08 2.61e-06 21/57 SLAMF7; XCL1; PTPRC; LYST; GNLY; IL7R; SERPINB9; HLA-E; NCR3; HSP90AB1; SH2D1A; RPL30; FAM49B; CRTAM; PRF1; PTPN6; IFNG; B2M; CORO1A; ARRB2; LGALS9
GO:0002576 platelet degranulation 3.63 4.93e-06 9.76e-05 15/41 FCER1G; TTN; TUBA4A; TEX264; ANXA5; FAM3C; TIMP1; FLNA; FAM49B; SRGN; CD63; CALM1; ACTN4; TGFB1; SOD1
GO:0006959 humoral immune response 3.58 2.51e-05 3.54e-04 13/36 PTPRC; CD55; GNLY; RBPJ; HLA-E; SH2D1A; RPL30; CD81; CD59; PTPN6; IFNG; GPR183; CCR7
GO:0002065 columnar/cuboidal epithelial cell differentiation 3.57 4.70e-04 3.51e-03 9/25 SLC4A7; RBPJ; SOX4; FAM65B; CDK6; FGFR1; HIF1A; SLC9A3R1; SOD1
GO:0002437 inflammatory response to antigenic stimulus 3.50 4.80e-03 2.44e-02 6/17 PARK7; FCER1G; RBPJ; HLA-E; IL2RA; CCR7
GO:0007187 G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger 3.41 1.78e-04 1.63e-03 11/32 RGS1; ATP2B4; RAMP1; PTGER4; HRH2; FLNA; ANXA1; PTGER2; SLC9A3R1; S1PR4; PTGIR
GO:0032635 interleukin-6 production 3.39 4.87e-05 6.01e-04 13/38 SLAMF1; FCER1G; CAPN2; INPP5D; SELK; CD47; PTPN6; PYCARD; CYBA; ARRB2; LGALS9; KLF2; XBP1
GO:0050900 leukocyte migration 3.38 1.89e-13 4.61e-11 42/123 TNFRSF18; LCK; CD2; FCER1G; XCL2; XCL1; SELL; LYST; GYPC; ITGA4; INPP5D; SELK; CD47; PTGER4; ADTRP; FAM65B; AIF1; GPSM3; FYN; MSN; CXCR3; DOK2; ANXA1; ITGB1; PTPN6; ITGB7; SELPLG; GPR183; LGALS3; SPN; CORO1A; ITGAL; PYCARD; LGALS9; CCL1; CCL5; CCR7; GRB2; TNFSF14; CALR; TGFB1; ITGB2
GO:0043062 extracellular structure organization 3.36 1.03e-06 3.01e-05 19/56 CTSS; CYP1B1; ITGA4; CFLAR; CD47; ADTRP; FLOT1; TIMP1; SDCBP; ITGB1; SPOCK2; NFKB2; ITGB7; ANXA2; ITGAL; P4HB; TGFB1; ITGB2; COL6A2
GO:1904019 epithelial cell apoptotic process 3.19 1.21e-03 7.97e-03 9/28 E2F2; DNMT3A; ITGA4; CFLAR; CAST; ARRB2; BCL2L1; STK4; ZFP36
GO:0071706 tumor necrosis factor superfamily cytokine production 3.18 9.10e-06 1.55e-04 17/53 CD2; SLAMF1; FCER1G; PTPRC; SELK; CD47; HLA-E; HSPB1; C10orf54; PTPN6; IFNG; SPN; PYCARD; CYBA; ARRB2; LGALS9; ZFP36
GO:0030048 actin filament-based movement 3.17 2.33e-03 1.41e-02 8/25 BIN1; TTN; FLNA; VIM; SYNE2; TPM4; ACTN4; SUN2
GO:0060326 cell chemotaxis 3.13 1.81e-07 6.63e-06 24/76 FCER1G; XCL2; XCL1; LYST; FAM65B; AIF1; GPSM3; HSPB1; CXCR3; FGFR1; ANXA1; BIN2; GPR183; LGALS3; CORO1A; ARRB2; LGALS9; CCL1; CCL5; CCR7; TNFSF14; CALR; TIAM1; ITGB2
GO:0002285 lymphocyte activation involved in immune response 3.12 3.43e-07 1.14e-05 23/73 FCER1G; PTPRC; PTGER4; HLA-DMB; MYB; ITM2A; RPS6; ANXA1; APBB1IP; IFNG; GPR183; LGALS3; BATF; RORA; SPN; CORO1A; ITGAL; LGALS9; TGFB1; RELB; XBP1; MFNG; LGALS1
GO:0032609 interferon-gamma production 3.11 4.34e-04 3.31e-03 11/35 CD2; XCL1; CD47; CD96; TXK; FAM49B; C10orf54; SPN; PYCARD; LGALS9; CCR7
GO:0007159 leukocyte cell-cell adhesion 3.09 1.71e-13 4.61e-11 48/154 LCK; XCL1; SELL; PTPRC; CD55; ITGA4; SELK; CD47; TIGIT; IL7R; TNIP1; ADTRP; FAM65B; HLA-E; AIF1; HLA-DMB; FYN; MYB; MAD1L1; MSN; FAM49B; ANXA1; IL2RA; MAP3K8; ITGB1; C10orf54; CD27; PTPN6; ITGB7; IFNG; SELPLG; LGALS3; SPN; CORO1A; ITGAL; PYCARD; CYLD; NFAT5; LGALS9; CCL5; CCR7; GRB2; TNFSF14; TGFB1; XBP1; LGALS1; GRAP2; ITGB2
GO:1901654 response to ketone 3.09 4.42e-06 9.14e-05 19/61 PARK7; TXNIP; CFLAR; PTGER4; NR3C1; MSN; FDX1; DDIT4; ATP2B1; PEBP1; PTGER2; CALM1; CYBA; CCR7; BCL2L1; CALR; KLF2; MAP4K1; TGFB1
GO:0070555 response to interleukin-1 3.08 8.37e-06 1.50e-04 18/58 GBP2; XCL2; XCL1; RPS27A; CD47; SKP1; ANXA1; MAP3K8; NFKBIA; HIF1A; RORA; PYCARD; CYBA; LGALS9; CCL1; CCL5; AES; KLF2
GO:0030101 natural killer cell activation 3.08 1.59e-03 1.01e-02 9/29 CD2; SLAMF7; PTPRC; CASP8; HLA-E; NCR3; IL21R; CORO1A; ITGB2
GO:0072507 divalent inorganic cation homeostasis 3.05 3.16e-11 3.31e-09 40/130 CD52; LCK; XCL1; PTPRC; ATP2B4; CD55; ITPR1; SELK; CCDC109B; ANXA5; PTGER4; BAK1; FYN; P2RY8; CXCR3; EPHX2; ANK3; BNIP3; PTPN6; TMBIM6; ATP2B1; TPT1; LPAR6; PTGER2; CALM1; ANXA2; PRKCB; CORO1A; MT2A; HERPUD1; CYBA; EIF5A; CCL1; CCL5; CCR7; FKBP1A; S1PR4; CALR; TGFB1; PTGIR
GO:0043112 receptor metabolic process 3.05 3.06e-06 7.24e-05 20/65 PARK7; FCER1G; RAB29; RAMP1; TRAT1; FLOT1; AHI1; SDCBP; CLTA; CD81; OPTN; ITGB1; INPP5F; CD63; HIF1A; ANXA2; ARRB2; GRB2; TGFB1; ITGB2
GO:0032103 positive regulation of response to external stimulus 3.00 1.48e-07 5.71e-06 26/86 PARK7; GBP5; FCER1G; XCL2; XCL1; CD47; PTGER4; TNIP1; FAM65B; HLA-E; AIF1; GPSM3; HSPB1; FGFR1; OPTN; NFKBIA; CYBA; LGALS9; CCL1; CCL5; CCR7; TNFSF14; CALR; TGFB1; TIAM1; ITGB2
GO:0010959 regulation of metal ion transport 2.97 1.01e-07 4.13e-06 27/90 XCL1; ATP2B4; BIN1; GLRX; BAK1; FYN; FLNA; SARAF; AHNAK; ANK3; PTPN6; TMBIM6; CD63; LGALS3; CALM1; B2M; ANXA2; CORO1A; CYBA; ARRB2; TRPV2; CCL5; SLC9A3R1; FKBP1A; FXYD5; ACTN4; TGFB1
GO:0045785 positive regulation of cell adhesion 2.95 5.97e-12 1.09e-09 45/151 TNFRSF18; LCK; S100A10; XCL1; PTPRC; CD55; ITGA4; SELK; CD47; IL7R; HLA-E; FLOT1; AIF1; HLA-DMB; FYN; MYB; CITED2; CDK6; FLNA; FAM49B; ANXA1; ARL2; IL2RA; APBB1IP; MAP3K8; ANK3; C10orf54; SPOCK2; CD27; PTPN6; IFNG; CORO1A; PYCARD; CYLD; NFAT5; LGALS9; CCL5; CCR7; GRB2; TNFSF14; CALR; TGFB1; XBP1; LGALS1; GRAP2
GO:0035637 multicellular organismal signaling 2.94 3.99e-03 2.20e-02 8/27 ATP2B4; BIN1; ITPR1; FLNA; ANK3; ATP2B1; CALM1; SOD1
GO:0097305 response to alcohol 2.91 2.41e-06 5.88e-05 22/75 DNMT3A; CASP8; EEF1B2; HPGD; PTGER4; BAK1; FYN; FDX1; CD27; ATP2B1; PEBP1; PTGER2; CALM1; CYBA; CCR7; BCL2L1; RGS19; KLF2; GRAMD1A; MAP4K1; TGFB1; SOD1
GO:0042110 T cell activation 2.87 1.78e-15 1.30e-12 62/214 TNFRSF18; LCK; CD2; FCER1G; XCL1; PTPRC; RAB29; CD55; ZFP36L2; CASP8; SELK; CD47; TIGIT; IL7R; PTGER4; CAMK4; SOX4; FAM65B; HLA-E; AIF1; HLA-DMB; CCND3; FYN; MYB; MAD1L1; MSN; FAM49B; RPS6; ANXA1; CD3G; CRTAM; IL2RA; APBB1IP; MAP3K8; C10orf54; CD27; PTPN6; IFNG; GPR183; LGALS3; BATF; BCL11B; B2M; RORA; LAT; SPN; CORO1A; ITGAL; PYCARD; CYLD; LGALS9; CCL5; CCR7; GRB2; FKBP1A; TNFSF14; TGFB1; RELB; XBP1; LGALS1; GRAP2; SOD1
GO:0022407 regulation of cell-cell adhesion 2.84 2.64e-11 3.22e-09 45/157 LCK; XCL1; PTPRC; CD55; ITGA4; SELK; CD47; TIGIT; IL7R; ADTRP; FAM65B; HLA-E; FLOT1; AIF1; HLA-DMB; FYN; MYB; CITED2; MAD1L1; FAM49B; ANXA1; RDX; IL2RA; MAP3K8; ANK3; C10orf54; CD27; PTPN6; IFNG; LGALS3; SPN; CORO1A; PYCARD; CYLD; NFAT5; LGALS9; CCL5; CCR7; GRB2; TNFSF14; FXYD5; TGFB1; XBP1; LGALS1; GRAP2
GO:0038061 NIK/NF-kappaB signaling 2.83 8.23e-05 9.00e-04 16/56 REL; SKP1; BIRC3; NFKB2; CD27; HDAC7; NFKBIA; LITAF; CYLD; NFAT5; LGALS9; TRAF4; TNFSF14; CALR; ACTN4; RELB
GO:0050920 regulation of chemotaxis 2.83 8.23e-05 9.00e-04 16/56 XCL2; XCL1; FAM65B; AIF1; GPSM3; HSPB1; FGFR1; GPR183; LGALS9; CCL1; CCL5; CCR7; TNFSF14; CALR; TGFB1; TIAM1
GO:0034109 homotypic cell-cell adhesion 2.83 5.10e-03 2.58e-02 8/28 HSPB1; FLNA; RDX; ANK3; PTPN6; CCL5; MYL12A; LGALS1
GO:0070972 protein localization to endoplasmic reticulum 2.78 1.38e-08 9.22e-07 34/121 RPS8; RPL5; RPS7; RPS27A; RPL37A; RPL32; RPL15; RPL9; RPS3A; RPS23; RPS18; RPL10A; RPL7; RPL30; RPS6; SEC61B; RPL12; RPL7A; RPL27A; RPS13; RPS25; RPS24; RPL6; RPS29; RPL4; RPLP1; RPS17; RPL23A; RPL23; RPL19; RPL18A; RPS9; RPS5; RPL3
GO:1903034 regulation of response to wounding 2.73 6.43e-03 3.12e-02 8/29 FCER1G; HPSE; ANXA5; ADTRP; ANXA1; INPP5F; ANXA2; XBP1
GO:0072511 divalent inorganic cation transport 2.71 7.56e-08 3.36e-06 32/117 LCK; XCL1; PTPRC; ATP2B4; BIN1; RAMP1; ITPR1; SELK; CCDC109B; ANXA5; BAK1; FYN; ORAI2; SARAF; AHNAK; PTPN6; TMBIM6; ATP2B1; TPT1; LGALS3; CALM1; ANXA2; PRKCB; CORO1A; CYBA; ARRB2; TRPV2; CCL5; CCR7; FKBP1A; TGFB1; KCNN4
GO:0070661 leukocyte proliferation 2.68 2.60e-07 9.08e-06 30/111 XCL1; PTPRC; CD55; INPP5D; SELK; IL7R; HLA-E; AIF1; HLA-DMB; CCND3; FYN; MAD1L1; MSN; RPS6; ANXA1; CD81; CRTAM; IL2RA; C10orf54; PTPN6; GPR183; LGALS3; SPN; CORO1A; PYCARD; LGALS9; CCL5; TNFSF14; TGFB1; CD79A
GO:0002237 response to molecule of bacterial origin 2.68 1.07e-06 3.01e-05 27/100 CD55; CAPN2; CASP8; CD96; HPGD; PTGER4; CSF2; HNRNPA0; CASP1; CARD16; IL10RA; VIM; NFKB2; NFKBIA; PTGER2; B2M; LITAF; PYCARD; LGALS9; CCL5; CCR7; JUNB; SIRT2; ZFP36; TGFB1; PTGIR; XBP1
GO:0050867 positive regulation of cell activation 2.65 8.42e-09 6.60e-07 38/142 LCK; CD2; FCER1G; XCL1; PTPRC; CD55; INPP5D; SELK; CD47; IL7R; HLA-E; AIF1; HLA-DMB; FYN; MYB; FAM49B; ANXA1; CD81; IL2RA; MAP3K8; C10orf54; CD27; PTPN6; IFNG; GPR183; CORO1A; PYCARD; CYLD; LGALS9; CCL5; CCR7; GRB2; TNFSF14; TGFB1; XBP1; LGALS1; GRAP2; ITGB2
GO:0048017 inositol lipid-mediated signaling 2.64 1.25e-03 8.17e-03 12/45 IER3; FYN; FGFR1; INPP5F; PTPN6; PPP2R5C; CCL5; SLC9A3R1; HCST; SIRT2; PIK3IP1; PRR5
GO:0071887 leukocyte apoptotic process 2.63 8.33e-04 5.70e-03 13/49 FCER1G; IL7R; BAK1; RPS6; ANXA1; CD3G; IL2RA; CD27; LGALS3; HIF1A; LGALS9; CCL5; CCR7
GO:0043491 protein kinase B signaling 2.62 9.04e-05 9.61e-04 18/68 PARK7; LCK; TRAT1; HPSE; ADTRP; HSP90AB1; FYN; FGFR1; ITGB1; INPP5F; OSBPL8; ARRB2; CCL5; CCR7; SLC9A3R1; GRB2; SIRT2; TGFB1
GO:0002521 leukocyte differentiation 2.60 1.78e-11 2.61e-09 53/202 TNFRSF18; LCK; CD2; IFI16; FCER1G; PTPRC; BATF3; IRF2BP2; ZFP36L2; ITGA4; CASP8; INPP5D; RBPJ; IL7R; PTGER4; CAMK4; CSF2; SOX4; BAK1; MYB; CDK6; ITM2A; RPS6; ANXA1; CD3G; IL2RA; ITGB1; C10orf54; FAM213A; CD27; PTPN6; IFNG; GPR183; LGALS3; BATF; GPR68; BCL11B; B2M; ANXA2; RORA; SPN; CYLD; LGALS9; EVI2B; CCR7; JUNB; TGFB1; CD79A; RELB; XBP1; MFNG; LGALS1; SOD1
GO:0007162 negative regulation of cell adhesion 2.60 1.82e-05 2.73e-04 22/84 XCL1; PTPRC; CYP1B1; TIGIT; ADTRP; FAM65B; MAD1L1; ANXA1; PDE3B; LPXN; RDX; IL2RA; C10orf54; PTPN6; ARHGDIB; LGALS3; SPN; LGALS9; FXYD5; ACTN4; TGFB1; LGALS1
GO:0043270 positive regulation of ion transport 2.56 4.55e-04 3.44e-03 15/58 PARK7; CTSS; XCL1; GLRX; BAK1; FLNA; ANK3; LGALS3; CALM1; ANXA2; ARRB2; TRPV2; CCL5; SLC9A3R1; ACTN4
GO:0051341 regulation of oxidoreductase activity 2.56 9.88e-03 4.39e-02 8/31 PARK7; ATP2B4; GZMA; IFNG; HIF1A; CALM1; CYBA; NOSIP
GO:0050727 regulation of inflammatory response 2.55 4.49e-06 9.14e-05 26/101 PARK7; GBP5; FCER1G; XCL1; PTPRC; CD55; CD47; PTGER4; TMEM173; TNIP1; HLA-E; GPSM3; ANXA1; CD81; CD59; BIRC3; IL2RA; NFKBIA; RORA; PYCARD; CYLD; CCL1; CCL5; CCR7; GPX4; ITGB2
GO:0008277 regulation of G protein-coupled receptor signaling pathway 2.55 6.49e-03 3.13e-02 9/35 RGS1; ATP2B4; RAMP1; GRK6; RGS3; NMT2; CALM1; ARRB2; CCL5
GO:0070371 ERK1 and ERK2 cascade 2.54 4.07e-05 5.23e-04 21/82 SLAMF1; XCL2; XCL1; PTPRC; ZFP36L2; CFLAR; PTGER4; TNIP1; DUSP4; FGFR1; PTPN6; GPR183; PYCARD; ARRB2; LGALS9; CCL1; CCL5; CCR7; SLC9A3R1; TGFB1; TIAM1
GO:0003007 heart morphogenesis 2.54 2.84e-03 1.64e-02 11/43 DHRS3; TTN; RBPJ; SOX4; PIM1; AHI1; CITED2; MICAL2; HIF1A; FKBP1A; TGFB1
GO:0061448 connective tissue development 2.54 2.84e-03 1.64e-02 11/43 CFLAR; TBL1XR1; NAMPT; TIMP1; FGFR1; HIF1A; CRIP1; ANXA2; TGFB1; XBP1; COL6A2
GO:0001818 negative regulation of cytokine production 2.53 8.17e-06 1.50e-04 25/98 SLAMF1; XCL1; PTPRC; REL; INPP5D; CD96; TIGIT; PTGER4; HSP90AB1; FGFR1; ANXA1; CARD16; SRGN; C10orf54; PTPN6; HDAC7; IFNG; PYCARD; CYLD; ARRB2; LGALS9; KLF2; ZFP36; TGFB1; RELB
GO:0050663 cytokine secretion 2.52 3.70e-04 2.92e-03 16/63 GBP5; CD2; SPTBN1; SELK; RBPJ; PTGER4; ANXA1; CASP1; CARD16; CRTAM; SRGN; PYCARD; LGALS9; CCL1; CCR7; XBP1
GO:2000147 positive regulation of cell motility 2.51 2.85e-08 1.49e-06 39/154 TNFRSF18; XCL2; XCL1; PTPRC; ITGA4; SELK; FAM65B; AIF1; GPSM3; HSPB1; FLNA; FGFR1; SDCBP; ANXA1; RRAS2; FAM89B; RDX; C10orf54; SPOCK2; HDAC7; IFNG; LGALS3; HIF1A; SYNE2; SPN; CORO1A; PYCARD; MAP2K3; LGALS9; CCL1; CCL5; CCR7; TNFSF14; CALR; ACTN4; TGFB1; XBP1; SUN2; TIAM1
GO:0002250 adaptive immune response 2.49 7.79e-08 3.36e-06 37/147 CTSS; SLAMF1; SLAMF7; FCER1G; XCL1; PTPRC; CD55; INPP5D; RFTN1; TRAT1; TXK; IL7R; CAMK4; HLA-E; FYN; SH2D1A; FAM49B; ANXA1; CD3G; CRTAM; PRF1; NFKB2; CD27; PTPN6; IFNG; GPR183; BATF; B2M; RORA; PRKCB; LAT; SPN; PYCARD; TGFB1; CD79A; RELB; LAIR1
GO:0001819 positive regulation of cytokine production 2.48 1.84e-08 1.13e-06 41/164 PARK7; GBP5; CD2; IFI16; FCER1G; XCL1; PTPRC; CYP1B1; SPTBN1; SELK; TIGIT; TXK; HPSE; PTGER4; CSF2; TMEM173; HLA-E; FLOT1; LTB; GPSM3; MYB; HSPB1; FAM49B; ANXA1; BIRC3; CASP1; CRTAM; NFKB2; IFNG; HIF1A; B2M; RORA; SPN; PYCARD; CYBA; LGALS9; CCL1; CCR7; TGFB1; XBP1; SOD1
GO:0006413 translational initiation 2.48 2.77e-08 1.49e-06 40/160 RPS8; RPL5; RPS7; RPS27A; EIF5B; RPL37A; RPL32; RPL15; RPL9; RPS3A; RPS23; NPM1; RPS18; RPL10A; HSPB1; RPL7; RPL30; PABPC1; RPS6; RPL12; RPL7A; RPL27A; RPS13; RPS25; RPS24; RPL6; RPS29; RPL4; RPLP1; RPS17; RPL23A; CCL5; RPL23; RPL19; EIF1; RPL18A; EIF3K; RPS9; RPS5; RPL3
GO:0045861 negative regulation of proteolysis 2.48 1.60e-06 4.19e-05 30/120 PARK7; TMEM59; RPL5; IFI16; CD55; RPS7; BIN1; CFLAR; RYBP; SIAH2; CAST; SERPINB9; SERPINB6; HSP90AB1; TIMP1; RENBP; SDCBP; CD59; BIRC3; CARD16; SORL1; SPOCK2; CD27; PEBP1; HERPUD1; ARRB2; RPL23; CST7; TNFSF14; CSTB
GO:0034765 regulation of ion transmembrane transport 2.48 5.99e-05 6.97e-04 21/84 PARK7; CTSS; XCL1; ATP2B4; BIN1; GLRX; FYN; FLNA; AHNAK; ANK3; PTPN6; CD63; HVCN1; CALM1; CORO1A; CYBA; SLC9A3R1; FKBP1A; FXYD5; ACTN4; TGFB1
GO:0006898 receptor-mediated endocytosis 2.48 1.34e-04 1.31e-03 19/76 FCER1G; ITGA4; RAMP1; FLOT1; AHI1; SNX9; SDCBP; CLTA; CD81; SORL1; ITGB1; INPP5F; CD63; B2M; ANXA2; ARRB2; GRB2; CALR; ITGB2
GO:0002064 epithelial cell development 2.48 6.73e-04 4.65e-03 15/60 SLC4A7; HRH2; FAM65B; CDK6; MSN; FLNA; FGFR1; RDX; VIM; RILPL2; HIF1A; BCL11B; SLC9A3R1; XBP1; SOD1
GO:2000027 regulation of animal organ morphogenesis 2.48 5.21e-03 2.62e-02 10/40 CFLAR; RBPJ; PIM1; AHI1; CITED2; FGFR1; ARRB2; TGFB1; XBP1; TIAM1
GO:0034612 response to tumor necrosis factor 2.45 2.16e-05 3.17e-04 24/97 TNFRSF18; TNFRSF9; GBP2; XCL2; XCL1; ZFP36L2; CASP8; LTB; TRAF1; BIRC3; CASP1; CARD16; CD27; NFKBIA; RORA; PYCARD; CYLD; CYBA; CCL1; CCL5; TNFSF14; KLF2; ACTN4; ZFP36
GO:0002449 lymphocyte mediated immunity 2.43 1.74e-05 2.65e-04 25/102 SLAMF7; FCER1G; XCL1; PTPRC; CD55; LYST; INPP5D; RFTN1; CD96; IL7R; SERPINB9; HLA-E; NCR3; SH2D1A; FAM49B; CRTAM; PRF1; CD27; PTPN6; BATF; B2M; CORO1A; ARRB2; LGALS9; TGFB1
GO:0008037 cell recognition 2.41 9.54e-03 4.26e-02 9/37 NCR3; MSN; YWHAZ; CRTAM; PRF1; HVCN1; LGALS3; CORO1A; CCR7
GO:0050866 negative regulation of cell activation 2.39 1.46e-03 9.47e-03 14/58 XCL1; PTPRC; INPP5D; TIGIT; FAM65B; MAD1L1; ANXA1; IL2RA; C10orf54; PTPN6; LGALS3; SPN; LGALS9; TGFB1
GO:0072593 reactive oxygen species metabolic process 2.38 3.72e-05 4.86e-04 24/100 PARK7; PRDX6; ATP2B4; CYP1B1; CFLAR; CD47; AIF1; HSP90AB1; FYN; EPHX2; DDIT4; BNIP3; IFNG; HIF1A; RORA; CYBA; EIF5A; GRB2; PMAIP1; KLF2; SIRT2; TGFB1; SOD1; ITGB2
GO:0002791 regulation of peptide secretion 2.37 1.42e-06 3.85e-05 33/138 CD2; GLUL; SPTBN1; TTN; ITPR1; SELK; ANXA5; PTGER4; ADTRP; SOX4; HLA-E; RAB11FIP1; ANXA1; ARL2; UCP2; CASP1; CARD16; CRTAM; SRGN; TMBIM6; IFNG; ERP29; HIF1A; GPR68; PYCARD; LGALS9; CCL1; CCL5; CCR7; TGFB1; KCNN4; XBP1; TIAM1
GO:0006909 phagocytosis 2.36 1.24e-04 1.24e-03 21/88 SLAMF1; FCER1G; PTPRC; ARHGAP25; CD47; LYAR; AIF1; HSP90AB1; FYN; ANXA1; CD3G; ITGB1; BIN2; CORO1A; ITGAL; PYCARD; CYBA; GRB2; CALR; TGFB1; ITGB2
GO:0009612 response to mechanical stimulus 2.36 1.16e-03 7.81e-03 15/63 TXNIP; TTN; CASP8; PTGER4; FAM65B; BAK1; FYN; CASP1; BNIP3; NFKBIA; CYBA; CNN2; TNFSF14; JUNB; TGFB1
GO:0060759 regulation of response to cytokine stimulus 2.34 6.17e-04 4.35e-03 17/72 PTPRC; CASP8; TXK; HSP90AB1; TRAF1; BIRC3; CASP1; CARD16; PTPN6; IFNG; HIF1A; PYCARD; CYLD; CCL5; SAMHD1; AES; IFNAR2
GO:0090150 establishment of protein localization to membrane 2.33 9.01e-09 6.60e-07 48/204 RPS8; RPL5; SSR2; RPS7; SPTBN1; RPS27A; CASP8; RPL37A; RPL32; RFTN1; RPL15; RPL9; RPS3A; RPS23; RPS18; RPL10A; FYN; AGK; SDCBP; RPL7; RPL30; YWHAZ; RPS6; SEC61B; RPL12; RPL7A; RPL27A; RPS13; RPS25; OPTN; ANK3; RPS24; RPL6; RILPL2; RPS29; CALM1; RPL4; RPLP1; RPS17; RPL23A; RPL23; RPL19; PMAIP1; RPL18A; RPS9; RPS5; RPL3; ITGB2
GO:0002694 regulation of leukocyte activation 2.32 7.08e-09 6.49e-07 49/209 TNFRSF18; LCK; CD2; FCER1G; XCL1; PTPRC; CD55; ZFP36L2; INPP5D; SELK; CD47; TIGIT; IL7R; CAMK4; FAM65B; HLA-E; AIF1; HLA-DMB; FYN; MYB; MAD1L1; FAM49B; ANXA1; CD81; IL2RA; MAP3K8; C10orf54; CD27; PTPN6; IFNG; GPR183; LGALS3; RORA; LAT; SPN; CORO1A; PYCARD; CYLD; LGALS9; CCL5; CCR7; GRB2; TNFSF14; TGFB1; XBP1; LGALS1; GRAP2; SOD1; ITGB2
GO:0048872 homeostasis of number of cells 2.31 1.49e-05 2.32e-04 28/120 FCER1G; INPP5D; LYAR; IL7R; SFXN1; BAK1; CDK6; RPS6; ANXA1; IL2RA; RPS24; GPR183; HIF1A; KLF13; B2M; RPS17; LAT; CORO1A; CYLD; LGALS9; CCR7; PMAIP1; TNFSF14; KLF2; ZFP36; TGFB1; PRMT1; SOD1
GO:0019932 second-messenger-mediated signaling 2.31 1.74e-04 1.63e-03 21/90 RCAN3; PTPRC; ATP2B4; RAMP1; ITPR1; SELK; TRAT1; PTGER4; CXCR3; PDE3B; PEBP1; PTGER2; CALM1; LAT; NFATC3; NFAT5; CCR7; SLC9A3R1; FKBP1A; S1PR4; PTGIR
GO:0045444 fat cell differentiation 2.30 3.10e-03 1.75e-02 13/56 ZFP36L2; TBL1XR1; PSMB8; TMEM120A; BNIP3; OSBPL8; RORA; STK4; SIRT2; ZFP36; TGFB1; ATF5; XBP1
GO:0097191 extrinsic apoptotic signaling pathway 2.29 1.38e-04 1.33e-03 22/95 PARK7; MLLT11; PTPRC; HTRA2; CFLAR; CASP8; SIAH2; TNFSF10; CSF2; BAK1; FYN; FGFR1; TRAF1; CD27; IFNG; LGALS3; PYCARD; CYLD; PMAIP1; BCL2L1; STK4; TGFB1
GO:0007249 I-kappaB kinase/NF-kappaB signaling 2.28 1.39e-05 2.21e-04 29/126 S100A4; RPS27A; REL; CFLAR; CASP8; SHISA5; TNFSF10; TIFA; TNIP1; FYN; HSPB1; FLNA; EEF1D; CARD19; BIRC3; CASP1; CARD16; OPTN; NDFIP2; NFKBIA; RORA; LITAF; PRKCB; PYCARD; LGALS9; CCR7; FKBP1A; RELB; LGALS1
GO:0008544 epidermis development 2.27 2.44e-03 1.47e-02 14/61 TXNIP; SLC4A7; RBPJ; HPSE; FAM65B; PERP; FGFR1; AQP3; ANXA1; BCL11B; SLC9A3R1; STK4; ZFP36; SOD1
GO:0051604 protein maturation 2.26 2.43e-05 3.49e-04 28/123 TMEM59; CTSS; IFI16; CD55; CAPN2; HTRA2; CASP8; MAGEF1; TSPAN5; CAST; SOX4; BAK1; PERP; PLGRKT; CD81; CD59; BIRC3; CASP1; CARD16; SORL1; SRGN; C10orf54; CPM; ANXA2; PYCARD; SEC11C; FKBP1A; CALR
GO:0003013 circulatory system process 2.25 3.60e-04 2.87e-03 20/88 XCL2; ATP2B4; BIN1; TTN; ITPR1; HRH2; FYN; NAMPT; RENBP; FLNA; EPHX2; ATP2B1; PEBP1; PTGER2; CALM1; CYBA; MAP2K3; SCPEP1; TGFB1; SOD1
GO:0031589 cell-substrate adhesion 2.25 3.60e-04 2.87e-03 20/88 S100A10; ITGA4; CD96; HPSE; CDK6; PRKX; FLNA; ARL2; ITGB1; SPOCK2; ITGB7; CD63; CORO1A; ITGAL; CCR7; CALR; ACTN4; LGALS1; TIAM1; ITGB2
GO:0002683 negative regulation of immune system process 2.24 1.90e-06 4.80e-05 36/159 IFI16; FCER1G; XCL1; PTPRC; CD55; INPP5D; CD47; CD96; TIGIT; GPR171; IL7R; PTGER4; SERPINB9; ADTRP; FAM65B; HLA-E; MAD1L1; CDK6; ANXA1; CD59; LPXN; IL2RA; C10orf54; PTPN6; TMBIM6; NFKBIA; LGALS3; GPR68; KLF13; SPN; ARRB2; LGALS9; SAMHD1; ZFP36; TGFB1; PRMT1
GO:0051235 maintenance of location 2.24 5.37e-05 6.34e-04 26/115 PARK7; LCK; XCL1; PTPRC; TMSB10; ITPR1; ANXA5; SKP1; FLNA; ARL2; SORL1; ANK3; SRGN; PTPN6; OSBPL8; NFKBIA; SYNE2; CALM1; CORO1A; CYBA; CCR7; FKBP1A; CALR; TGFB1; FTL; SUN2
GO:0002697 regulation of immune effector process 2.24 5.36e-06 1.03e-04 33/146 FCER1G; XCL1; PTPRC; CD55; SELK; CD47; CD96; IL7R; TMEM173; SERPINB9; HLA-E; NCR3; HLA-DMB; MYB; SH2D1A; FAM49B; ANXA1; CD81; CD59; BIRC3; CRTAM; IL2RA; PTPN6; TMBIM6; IFNG; LGALS3; B2M; PYCARD; ARRB2; LGALS9; TGFB1; XBP1; ITGB2
GO:0042692 muscle cell differentiation 2.24 2.84e-04 2.36e-03 21/93 CD53; PLEKHO1; CAPN2; H3F3A; BIN1; TTN; CFLAR; CAMK1; RBPJ; FAM65B; FLOT1; ITGB1; RORA; TMEM204; NFATC3; ARRB2; EIF5A; TNFSF14; CALR; TGFB1; XBP1
GO:0001505 regulation of neurotransmitter levels 2.23 1.51e-03 9.71e-03 16/71 PARK7; GLUL; ATP2B4; CYP1B1; CD47; FLOT1; AIF1; HSP90AB1; PTPRN2; IFNG; PEBP1; CALM1; RORA; PRKCB; KLF2; ITGB2
GO:0001525 angiogenesis 2.23 4.23e-05 5.34e-04 27/120 E2F2; SH2D2A; GLUL; CYP1B1; RAMP1; RBPJ; HPSE; ADTRP; HSPB1; SRPK2; PRKX; CXCR3; FGFR1; ANXA1; PDE3B; ITGB1; HDAC7; HIF1A; ANXA2; RORA; PKM; PRKCB; RNF213; STK4; KLF2; XBP1; ITGB2
GO:0034341 response to interferon-gamma 2.22 6.27e-04 4.37e-03 19/85 GBP2; GBP5; XCL2; XCL1; CD47; TXK; HLA-E; AIF1; HLA-DRA; HLA-DQA1; HSP90AB1; CASP1; VIM; IFNG; B2M; MT2A; LGALS9; CCL1; CCL5
GO:0052547 regulation of peptidase activity 2.21 3.86e-06 8.58e-05 35/157 PARK7; LCK; IFI16; HTRA2; BIN1; CFLAR; CASP8; SIAH2; TNFSF10; CAST; SERPINB9; SERPINB6; PSMB8; BAK1; FYN; PERP; TIMP1; RENBP; BIRC3; CASP1; CARD16; SORL1; C10orf54; SPOCK2; CD27; PEBP1; PSME1; PYCARD; HERPUD1; ARRB2; LGALS9; PMAIP1; CST7; TNFSF14; CSTB
GO:0045088 regulation of innate immune response 2.20 5.74e-06 1.08e-04 34/153 GBP5; CTSS; IFI16; FCER1G; RPS27A; CASP8; RFTN1; CD96; TXK; TIFA; TMEM173; TNIP1; SERPINB9; HLA-E; FLOT1; NCR3; HSP90AB1; FYN; SH2D1A; BIRC3; CRTAM; PTPN6; IFNG; NFKBIA; PYCARD; CYLD; CYBA; ARRB2; LGALS9; CCL5; SAMHD1; RELB; IFNAR2; ITGB2
GO:0051047 positive regulation of secretion 2.20 7.32e-05 8.38e-04 26/117 CD2; FCER1G; GLUL; SPTBN1; TTN; SELK; PTGER4; SOX4; HLA-E; MYB; FGFR1; SDCBP; SYTL2; CASP1; CRTAM; IFNG; HIF1A; GPR68; PYCARD; CYBA; LGALS9; CCL1; TGFB1; KCNN4; XBP1; ITGB2
GO:0090287 regulation of cellular response to growth factor stimulus 2.20 3.36e-03 1.88e-02 14/63 RPS27A; CFLAR; RBPJ; HSP90AB1; CITED2; FGFR1; SDCBP; FAM89B; CD63; HIF1A; TMEM204; PRKCB; LDLRAD4; TGFB1
GO:0033002 muscle cell proliferation 2.16 7.49e-03 3.50e-02 12/55 CFLAR; RBPJ; HPGD; AIF1; PIM1; MYB; NAMPT; FGFR1; IFNG; CYBA; CCL5; PTGIR
GO:0031349 positive regulation of defense response 2.16 9.01e-06 1.55e-04 34/156 PARK7; GBP5; CTSS; IFI16; FCER1G; RPS27A; CASP8; RFTN1; CD47; TXK; TIFA; PTGER4; TMEM173; TNIP1; HLA-E; FLOT1; NCR3; GPSM3; FYN; SH2D1A; BIRC3; CRTAM; OPTN; NFKBIA; PYCARD; CYLD; CYBA; ARRB2; LGALS9; CCL1; CCL5; CCR7; RELB; ITGB2
GO:0030099 myeloid cell differentiation 2.16 3.72e-06 8.52e-05 37/170 IFI16; FCER1G; BATF3; H3F3A; CASP8; INPP5D; GPR171; LYAR; RBPJ; CAMK4; CSF2; SFXN1; CDK6; PRKX; RPS6; FAM213A; PTPN6; IFNG; GPR183; NFKBIA; LGALS3; HIF1A; BATF; GPR68; KLF13; B2M; ANXA2; PRKCB; LGALS9; EVI2B; CCR7; JUNB; KLF2; ZFP36; TGFB1; RELB; PRMT1
GO:0071559 response to transforming growth factor beta 2.15 3.05e-03 1.74e-02 15/69 XCL1; ZFP36L2; RPS27A; CFLAR; HPGD; NR3C1; HSP90AB1; FYN; CITED2; SDCBP; FAM89B; ITGB1; ARRB2; LDLRAD4; TGFB1
GO:0010038 response to metal ion 2.14 2.16e-04 1.93e-03 24/111 PARK7; TXNIP; DNMT3A; TTN; CASP8; ANXA5; CUTA; AQP3; RASGRP2; ANK3; BNIP3; HVCN1; PEBP1; HIF1A; CALM1; CRIP1; B2M; FUS; MT2A; CYB5A; ATP5D; JUNB; CALR; SOD1
GO:1990778 protein localization to cell periphery 2.13 1.32e-04 1.31e-03 26/121 EPB41; TMEM59; S100A10; FCER1G; RAB29; SPTBN1; RAMP1; TSPAN5; FYB; FLOT1; FAM126A; FLNA; SYTL2; RDX; OPTN; ITGB1; ANK3; ARL3; IFNG; RILPL2; LGALS3; ANXA2; SLC9A3R1; BCL2L1; PLEKHF1; TGFB1
GO:0071496 cellular response to external stimulus 2.12 1.04e-04 1.09e-03 27/126 IFI16; GLUL; PTPRC; NCOA1; CASP8; PTGER4; FAM65B; AIF1; BAK1; PIM1; FYN; UPP1; NAMPT; AQP3; UCP2; CASP1; BNIP3; HNRNPA1; ATP2B1; CYBA; PMAIP1; CNN2; AES; TNFSF14; TGFB1; XBP1; SOD1
GO:0044706 multi-multicellular organism process 2.12 8.69e-03 3.91e-02 12/56 CAPN2; H3F3A; HPGD; NAMPT; TIMP1; UCP2; ARHGDIB; LGALS9; JUNB; CALR; TGFB1; SOD1
GO:0051346 negative regulation of hydrolase activity 2.10 3.02e-05 4.18e-04 32/151 PARK7; IFI16; BIN1; CFLAR; SIAH2; PPP1R2; GZMA; IQGAP2; CAST; SERPINB9; SERPINB6; PTPRN2; TIMP1; RENBP; ANXA1; ARL2; SYTL2; BIRC3; CARD16; RDX; SORL1; SPOCK2; CD27; TMBIM6; PEBP1; LGALS3; HERPUD1; ARRB2; FKBP1A; CST7; TNFSF14; CSTB
GO:0042113 B cell activation 2.09 4.24e-04 3.30e-03 23/109 PTPRC; IRF2BP2; ZFP36L2; ITGA4; CASP8; INPP5D; RBPJ; IL7R; BAK1; ITM2A; CD81; ITGB1; CD27; PTPN6; GPR183; BATF; PRKCB; CYLD; TGFB1; CD79A; XBP1; MFNG; LGALS1
GO:1903706 regulation of hemopoiesis 2.09 1.12e-05 1.87e-04 36/171 TNFRSF18; CD2; PTPRC; H3F3A; ZFP36L2; CASP8; INPP5D; GPR171; IL7R; CAMK4; CSF2; MYB; CDK6; ANXA1; IL2RA; C10orf54; FAM213A; CD27; PTPN6; IFNG; NFKBIA; LGALS3; HIF1A; GPR68; KLF13; B2M; PRKCB; CYLD; LGALS9; EVI2B; ZFP36; TGFB1; PRMT1; XBP1; LGALS1; SOD1
GO:0046677 response to antibiotic 2.06 2.31e-04 2.04e-03 26/125 PARK7; ID3; TXNIP; CAPN2; DNMT3A; CYP1B1; CASP8; EEF1B2; HPGD; BAK1; FYN; MYB; ANXA1; FDX1; BNIP3; CD27; HNRNPA1; PEBP1; CRIP1; RPL23; BCL2L1; RGS19; KLF2; SOD1; MT-ND5; MT-ND6
GO:1901342 regulation of vasculature development 2.06 3.65e-03 2.02e-02 16/77 E2F2; GLUL; CYP1B1; CFLAR; HSPB1; ANXA1; PDE3B; ITGB1; HDAC7; HIF1A; PKM; PRKCB; NFATC3; KLF2; XBP1; ITGB2
GO:0009410 response to xenobiotic stimulus 2.04 6.92e-03 3.31e-02 14/68 DNMT3A; CYP1B1; CFLAR; NR3C1; AIF1; HSP90AB1; EPHX2; DDIT4; CALM1; RORA; TGFB1; TIAM1; SOD1; MT-ND6
GO:0031348 negative regulation of defense response 2.01 1.02e-02 4.50e-02 13/64 IFI16; PTPRC; CD96; PTGER4; SERPINB9; HLA-E; IL2RA; RORA; PYCARD; ARRB2; LGALS9; SAMHD1; SIRT2
GO:0002764 immune response-regulating signaling pathway 2.01 4.30e-06 9.14e-05 43/212 THEMIS2; LCK; CTSS; FCER1G; PTPRC; RAB29; RPS27A; CASP8; INPP5D; RFTN1; CD47; TRAT1; TXK; TIFA; FYB; TNIP1; FLOT1; NCR3; HLA-DRA; HLA-DQA1; HSP90AB1; FYN; LPXN; BIRC3; CD3G; PTPN6; NFKBIA; LGALS3; CALM1; PRKCB; LAT; CYLD; NFATC3; CYBA; ARRB2; LGALS9; CCR7; GRB2; CD79A; KCNN4; RELB; GRAP2; ITGB2
RASA2 : 46 significant GO terms
GeneSet description enrichRatio pValue FDR GeneRatio geneSymbols
GO:1990868 response to chemokine 11.70 7.44e-06 6.78e-04 6/20 XCL2; XCL1; CXCR4; CXCL10; CXCR3; CCR7
GO:0035456 response to interferon-beta 10.20 9.07e-05 3.69e-03 5/19 PYHIN1; STAT1; IRF1; TMEM173; IFITM2
GO:0097366 response to bronchodilator 9.15 7.67e-04 1.94e-02 4/17 CFLAR; RGS10; CALM1; CCR7
GO:0034341 response to interferon-gamma 8.23 2.10e-12 1.54e-09 18/85 GBP5; XCL2; XCL1; STAT1; IRF1; HLA-F; HLA-E; HLA-DRA; HLA-DRB5; HLA-DRB1; HLA-DQA1; HLA-DQB1; HLA-DPA1; HLA-DPB1; IFITM2; B2M; LGALS9; ACTG1
GO:0032615 interleukin-12 production 8.18 1.20e-03 2.31e-02 4/19 TIGIT; IRF1; LGALS9; CCR7
GO:0033627 cell adhesion mediated by integrin 8.18 1.20e-03 2.31e-02 4/19 CYP1B1; ITGB1; ITGB7; TESC
GO:0070265 necrotic cell death 7.78 3.66e-04 1.22e-02 5/25 CFLAR; BIRC3; TMEM123; FAS; TSPO
GO:0055123 digestive system development 7.07 2.13e-03 3.48e-02 4/22 ID2; TCF7; PRDM1; AHI1
GO:0032609 interferon-gamma production 6.66 2.27e-04 8.31e-03 6/35 XCL1; CD96; HLA-DPA1; HLA-DPB1; LGALS9; CCR7
GO:0043062 extracellular structure organization 6.25 1.02e-05 6.78e-04 9/56 CYP1B1; CAPG; CFLAR; ITGA1; FSCN1; ITGB1; ITGB7; PECAM1; COL6A2
GO:0050920 regulation of chemotaxis 6.25 1.02e-05 6.78e-04 9/56 XCL2; XCL1; CXCR4; CXCL10; CD74; CORO1B; IL16; LGALS9; CCR7
GO:0019882 antigen processing and presentation 6.16 3.66e-09 1.34e-06 16/101 CD8A; CD74; HLA-F; HLA-E; HLA-DRA; HLA-DRB5; HLA-DRB1; HLA-DQA1; HLA-DQB1; TAP1; HLA-DMB; HLA-DPA1; HLA-DPB1; PSME1; B2M; CCR7
GO:0002576 platelet degranulation 5.69 5.54e-04 1.56e-02 6/41 TUBA4A; CTSW; CD63; ACTN1; CALM1; PECAM1
GO:0060326 cell chemotaxis 5.63 2.95e-06 3.09e-04 11/76 XCL2; XCL1; CXCR4; CXCL10; ITGA1; CD74; CXCR3; CORO1B; IL16; LGALS9; CCR7
GO:0050900 leukocyte migration 5.37 9.87e-09 2.41e-06 17/123 XCL2; XCL1; SELL; CXCR4; CXCL10; PTGER4; ITGA1; CD74; CXCR3; DOK2; ITGB1; ITGB7; IL16; LGALS9; CCR7; PECAM1; SIRPG
GO:0034340 response to type I interferon 5.18 9.22e-04 2.12e-02 6/45 STAT1; IRF1; HLA-F; HLA-E; IFITM2; ISG20
GO:0032103 positive regulation of response to external stimulus 4.97 1.01e-05 6.78e-04 11/86 GBP5; XCL2; XCL1; CXCL10; PTGER4; CD74; HLA-E; NFKBIA; IL16; LGALS9; CCR7
GO:0001906 cell killing 4.77 5.74e-04 1.56e-02 7/57 XCL1; IL7R; HLA-F; HLA-E; GZMB; B2M; LGALS9
GO:1901654 response to ketone 4.46 8.70e-04 2.12e-02 7/61 CFLAR; PTGER4; DDIT4; ATP2B1; CALM1; CCR7; TSPO
GO:0007159 leukocyte cell-cell adhesion 4.29 2.93e-07 4.29e-05 17/154 XCL1; SELL; TIGIT; IL7R; IRF1; CD74; HLA-E; HLA-DMB; HLA-DPA1; HLA-DPB1; ITGB1; ITGB7; LGALS9; CCR7; PECAM1; SIRPG; TMIGD2
GO:0070661 leukocyte proliferation 4.20 2.28e-05 1.19e-03 12/111 XCL1; IL7R; IRF1; CD74; HLA-E; HLA-DMB; HLA-DPA1; HLA-DPB1; CCND3; LGALS9; TMIGD2; CD79A
GO:0002449 lymphocyte mediated immunity 4.19 5.19e-05 2.54e-03 11/102 XCL1; CD8A; CD96; IL7R; CD74; HLA-F; HLA-E; HLA-DQB1; GZMB; B2M; LGALS9
GO:0001655 urogenital system development 4.19 1.28e-03 2.40e-02 7/65 ID3; ID2; STAT1; CFLAR; AHI1; ARID5B; PECAM1
GO:0001819 positive regulation of cytokine production 4.03 7.28e-07 8.89e-05 17/164 GBP5; XCL1; CYP1B1; STAT1; TIGIT; PTGER4; IRF1; TMEM173; CD74; HLA-E; HLA-DPA1; HLA-DPB1; BIRC3; B2M; LGALS9; CCR7; TMIGD2
GO:0003013 circulatory system process 3.98 3.83e-04 1.22e-02 9/88 XCL2; ID2; STAT1; ITPR1; CXCL10; ITGA1; EPHX2; ATP2B1; CALM1
GO:0019932 second-messenger-mediated signaling 3.89 4.53e-04 1.35e-02 9/90 CXCR4; ITPR1; CXCL10; PTGER4; HINT1; PRKAR1B; CXCR3; CALM1; CCR7
GO:0002440 production of molecular mediator of immune response 3.84 1.03e-03 2.15e-02 8/81 XCL1; CD96; IL7R; CD74; HLA-E; HLA-DQB1; B2M; TMIGD2
GO:0042110 T cell activation 3.82 8.09e-08 1.48e-05 21/214 XCL1; CD8A; TIGIT; IL7R; PTGER4; IRF1; TCF7; CD74; HLA-E; HLA-DMB; HLA-DPA1; HLA-DPB1; CCND3; PRDM1; SIT1; B2M; LGALS9; CCR7; CD7; SIRPG; TMIGD2
GO:0070371 ERK1 and ERK2 cascade 3.79 1.11e-03 2.27e-02 8/82 XCL2; XCL1; CFLAR; PTGER4; CD74; DUSP4; LGALS9; CCR7
GO:0002250 adaptive immune response 3.70 2.00e-05 1.19e-03 14/147 XCL1; CD8A; IL7R; IRF1; CD74; HLA-F; HLA-E; HLA-DQB1; TAP1; PRDM1; SIT1; B2M; CD7; CD79A
GO:0009615 response to virus 3.68 2.16e-05 1.19e-03 14/148 XCL1; CXCR4; STAT1; CXCL10; IRF1; TMEM173; PIM2; IFITM2; BIRC3; DDIT4; NPC2; ISG20; RPS15A; LGALS9
GO:0031589 cell-substrate adhesion 3.53 1.76e-03 3.01e-02 8/88 CD96; ITGA1; ITGB1; ITGB7; CD63; ACTN1; CCR7; PECAM1
GO:0002237 response to molecule of bacterial origin 3.50 9.83e-04 2.12e-02 9/100 CD96; CXCL10; PTGER4; NFKBIA; B2M; LITAF; LGALS9; CCR7; TSPO
GO:0010959 regulation of metal ion transport 3.46 2.04e-03 3.40e-02 8/90 XCL1; CXCL10; CD63; TESC; CALM1; B2M; IL16; TSPO
GO:0072507 divalent inorganic cation homeostasis 3.29 4.59e-04 1.35e-02 11/130 XCL1; CXCR4; ITPR1; CXCL10; PTGER4; CXCR3; EPHX2; ATP2B1; CALM1; HERPUD1; CCR7
GO:0048872 homeostasis of number of cells 3.24 9.44e-04 2.12e-02 10/120 ID2; STAT1; IL7R; CD74; SFXN1; SIT1; B2M; RPS17; LGALS9; CCR7
GO:0022407 regulation of cell-cell adhesion 3.22 1.72e-04 6.62e-03 13/157 XCL1; TIGIT; IL7R; IRF1; CD74; HLA-E; HLA-DMB; HLA-DPA1; HLA-DPB1; LGALS9; CCR7; SIRPG; TMIGD2
GO:0002697 regulation of immune effector process 3.20 3.30e-04 1.15e-02 12/146 XCL1; STAT1; CD96; IL7R; TMEM173; CD74; HLA-F; HLA-E; HLA-DMB; BIRC3; B2M; LGALS9
GO:0007249 I-kappaB kinase/NF-kappaB signaling 3.09 1.37e-03 2.52e-02 10/126 RHOC; STAT1; CFLAR; CD74; PIM2; BIRC3; NFKBIA; LITAF; LGALS9; CCR7
GO:0050867 positive regulation of cell activation 3.01 9.69e-04 2.12e-02 11/142 XCL1; IL7R; CD74; HLA-E; HLA-DMB; HLA-DPA1; HLA-DPB1; LGALS9; CCR7; SIRPG; TMIGD2
GO:0002694 regulation of leukocyte activation 2.98 7.62e-05 3.49e-03 16/209 XCL1; ID2; TIGIT; IL7R; IRF1; CD74; HLA-E; HLA-DMB; HLA-DPA1; HLA-DPB1; PRDM1; SIT1; LGALS9; CCR7; SIRPG; TMIGD2
GO:0002764 immune response-regulating signaling pathway 2.93 9.04e-05 3.69e-03 16/212 IRF1; HLA-DRA; HLA-DRB5; HLA-DRB1; HLA-DQA1; HLA-DQB1; HLA-DPA1; HLA-DPB1; BIRC3; NFKBIA; CALM1; HSP90AA1; LGALS9; CCR7; ACTG1; CD79A
GO:0045785 positive regulation of cell adhesion 2.83 1.60e-03 2.87e-02 11/151 XCL1; IL7R; CD74; HLA-E; HLA-DMB; HLA-DPA1; HLA-DPB1; LGALS9; CCR7; SIRPG; TMIGD2
GO:0098542 defense response to other organism 2.81 1.69e-03 2.95e-02 11/152 STAT1; CXCL10; PLAC8; IRF1; TMEM173; HLA-E; IFITM2; BIRC3; DDIT4; ISG20; COTL1
GO:0002521 leukocyte differentiation 2.69 6.13e-04 1.60e-02 14/202 ID2; CD8A; IL7R; PTGER4; IRF1; TCF7; CD74; PRDM1; ITGB1; TESC; B2M; LGALS9; CCR7; CD79A
GO:0002683 negative regulation of immune system process 2.69 2.42e-03 3.86e-02 11/159 XCL1; ID2; CD96; TIGIT; IL7R; PTGER4; IRF1; CD74; HLA-E; NFKBIA; LGALS9
TCEB2 : 79 significant GO terms
GeneSet description enrichRatio pValue FDR GeneRatio geneSymbols
GO:0070972 protein localization to endoplasmic reticulum 8.13 0.00e+00 0.00e+00 57/121 RPL11; RPS8; RPL5; RPS27; RPS7; RPS27A; RPL31; RPL32; RPL15; RPSA; RPL29; RPL34; RPS3A; RPL37; RPS14; RPS18; RPL10A; RPS12; SEC61G; INSIG1; RPS4X; RPL39; RPL7; RPL30; RPS6; RPL35; RPL12; RPL7A; RPL27A; RPS13; RPS3; RPS25; RPS24; RPL41; RPL6; RPLP0; RPL21; RPS29; RPL4; RPLP1; RPS17; RPS2; RPL13; RPL26; RPL23; RPL19; RPL38; RPS15; RPS28; RPL18A; RPS16; RPL18; RPL13A; RPS9; RPL28; RPS5; RPL3
GO:0042116 macrophage activation 6.75 2.60e-06 9.54e-05 9/23 JUN; PTPRC; CSF2; CD74; NAMPT; MFHAS1; HMGB1; MIF; ITGB2
GO:0050918 positive chemotaxis 6.27 2.64e-03 2.89e-02 4/11 HMGB1; CORO1A; CCL5; MIF
GO:0006413 translational initiation 6.25 0.00e+00 0.00e+00 58/160 RPL11; RPS8; RPL5; RPS27; RPS7; RPS27A; RPL31; RPL32; RPL15; RPSA; RPL29; RPL34; RPS3A; RPL37; RPS14; RPS18; RPL10A; RPS12; RPS4X; RPL39; RPL7; RPL30; RPS6; RPL35; RPL12; RPL7A; RPL27A; RPS13; RPS3; RPS25; RPS24; RPL41; RPL6; RPLP0; RPL21; RPS29; RPL4; RPLP1; RPS17; RPS2; RPL13; RPL26; CCL5; RPL23; RPL19; EIF1; RPL38; RPS15; RPS28; RPL18A; RPS16; RPL18; RPL13A; RPS9; RPL28; RPS5; RPL3; ATF4
GO:0046939 nucleotide phosphorylation 6.16 4.69e-09 4.30e-07 15/42 ENO1; PGM1; GUK1; PGK1; LDHA; PFKP; DDIT4; PGAM1; GAPDH; TPI1; ENO2; PKM; ALDOA; ALDOC; GPI
GO:0006090 pyruvate metabolic process 5.63 6.37e-09 4.67e-07 16/49 ENO1; PGM1; VDAC1; PGK1; LDHA; PFKP; DDIT4; PGAM1; GAPDH; TPI1; ENO2; PKM; ALDOA; ALDOC; SLC16A3; GPI
GO:0009132 nucleoside diphosphate metabolic process 5.63 6.37e-09 4.67e-07 16/49 ENO1; AK2; PGM1; GUK1; PGK1; LDHA; PFKP; DDIT4; PGAM1; GAPDH; TPI1; ENO2; PKM; ALDOA; ALDOC; GPI
GO:0034113 heterotypic cell-cell adhesion 5.39 1.63e-03 1.99e-02 5/16 LCK; CD58; PTPRC; CD44; ITGB2
GO:0090150 establishment of protein localization to membrane 4.90 0.00e+00 0.00e+00 58/204 RPL11; RPS8; RPL5; RPS27; RPS7; RPS27A; RPL31; RPL32; RPL15; RPSA; RPL29; RPL34; RPS3A; RPL37; RPS14; RPS18; RPL10A; RPS12; RPS4X; RPL39; RPL7; RPL30; RPS6; RPL35; RPL12; RPL7A; RPL27A; RPS13; RPS3; RPS25; RPS24; RPL41; RPL6; RPLP0; RPL21; GZMB; RPS29; RPL4; RPLP1; RPS17; RPS2; RPL13; RPL26; RPL23; RPL19; RPL38; PMAIP1; RPS15; RPS28; RPL18A; RPS16; RPL18; RPL13A; RPS9; RPL28; RPS5; RPL3; ITGB2
GO:0016052 carbohydrate catabolic process 4.84 7.21e-08 4.80e-06 16/57 ENO1; PGM1; PGK1; FUT7; LDHA; PFKP; DDIT4; PGAM1; GAPDH; TPI1; ENO2; HMGB1; PKM; ALDOA; ALDOC; GPI
GO:0032602 chemokine production 4.79 2.90e-03 3.05e-02 5/18 CD74; GSTP1; HMGB1; PYCARD; MIF
GO:0002181 cytoplasmic translation 4.66 3.29e-09 3.45e-07 20/74 RPL11; RPL31; RPL32; RPL15; RPL29; RPL10A; RPL39; RPL30; RPL41; RPL6; RPLP0; RPS29; RPLP1; RPL26; RPL19; RPL38; RPS28; RPL18A; RPL18; RPL13A
GO:0033627 cell adhesion mediated by integrin 4.54 3.75e-03 3.67e-02 5/19 DPP4; PTPN6; CCL5; ADA; ITGB2
GO:0072524 pyridine-containing compound metabolic process 4.12 8.23e-07 3.35e-05 16/67 ENO1; PGM1; NAMPT; PGK1; LDHA; PFKP; DDIT4; PGAM1; GAPDH; TPI1; ENO2; PKM; IDH2; ALDOA; ALDOC; GPI
GO:0006401 RNA catabolic process 4.02 0.00e+00 0.00e+00 59/253 RPL11; RPS8; RPL5; RPS27; RPS7; ZFP36L2; RPS27A; RPL31; RPL32; RPL15; RPSA; RPL29; RPL34; RPS3A; RPL37; RPS14; RPS18; RPL10A; RPS12; RPS4X; RPL39; RPL7; RPL30; RPS6; RPL35; RPL12; RPL7A; RPL27A; RPS13; RPS3; RPS25; VIM; RPS24; RPL41; RPL6; RPLP0; RPL21; RPS29; RPL4; RPLP1; RPS17; RPS2; RPL13; RPL26; ALKBH5; RPL23; RPL19; DDX5; RPL38; RPS15; RPS28; RPL18A; RPS16; RPL18; RPL13A; RPS9; RPL28; RPS5; RPL3
GO:0006605 protein targeting 3.99 0.00e+00 0.00e+00 59/255 RPL11; ATPIF1; RPS8; RPL5; RPS27; RPS7; RPS27A; RPL31; RPL32; RPL15; RPSA; RPL29; RPL34; RPS3A; RPL37; RPS14; RPS18; RPL10A; RPS12; SEC61G; RPS4X; RPL39; BNIP3L; RPL7; RPL30; RPS6; RPL35; RPL12; RPL7A; RPL27A; RPS13; RPS3; RPS25; RPS24; RPL41; RPL6; RPLP0; RPL21; RPS29; RPL4; RPLP1; RPS17; RPS2; RPL13; RPL26; RPL23; RPL19; RPL38; RPS15; RPS28; RPL18A; RPS16; RPL18; RPL13A; RPS9; RPL28; RPS5; RPL3; ITGB2
GO:0006959 humoral immune response 3.83 8.43e-04 1.19e-02 8/36 PTPRC; RPL39; RPL30; GATA3; GAPDH; PTPN6; GPR183; GPI
GO:0070371 ERK1 and ERK2 cascade 3.79 6.46e-07 2.78e-05 18/82 JUN; RAP1A; PTPRC; ZFP36L2; CD74; MFHAS1; PRKCDBP; CD44; GSTP1; PTPN6; HMGB1; GPR183; CTSH; PYCARD; CCL1; CCL5; MIF; DDT
GO:0034404 nucleobase-containing small molecule biosynthetic process 3.53 1.94e-06 7.48e-05 18/88 ENO1; PGM1; GUK1; PGK1; LDHA; PFKP; DDIT4; PGAM1; GAPDH; TPI1; ENO2; PKM; ALDOA; ALDOC; TK1; ADA; GPI; TYMP
GO:0071887 leukocyte apoptotic process 3.52 4.00e-04 6.69e-03 10/49 TNFRSF4; CD74; TSC22D3; RPS6; CD3G; IL2RA; CD27; CCL5; ADA; MIF
GO:0070671 response to interleukin-12 3.45 3.38e-03 3.39e-02 7/35 CFL1; RPLP0; LCP1; P4HB; CNN2; MIF; SOD1
GO:0046434 organophosphate catabolic process 3.40 2.23e-05 5.45e-04 15/76 ENO1; PGM1; PGK1; LDHA; PFKP; DDIT4; PGAM1; GAPDH; TPI1; ENO2; PKM; ALDOA; ALDOC; ADA; GPI
GO:0043062 extracellular structure organization 3.39 2.94e-04 5.52e-03 11/56 DPP4; ADTRP; TIMP1; CD44; SPOCK2; P4HA1; LCP1; ERO1A; PECAM1; P4HB; ITGB2
GO:0050900 leukocyte migration 3.37 9.25e-08 5.65e-06 24/123 TNFRSF18; LCK; CD58; CD74; ADTRP; GPSM3; CXCR3; FUT7; CD44; GATA3; PTPN6; HMGB1; GPR183; CORO1A; PYCARD; CCL1; CCL5; PECAM1; SLC16A3; SIRPG; ADA; MIF; DDT; ITGB2
GO:0002576 platelet degranulation 3.37 2.07e-03 2.40e-02 8/41 TAGLN2; TIMP1; CTSW; SRGN; ACTN1; ALDOA; PECAM1; SOD1
GO:0005996 monosaccharide metabolic process 3.20 8.35e-06 2.35e-04 18/97 ENO1; PGM1; PGK1; FUT7; PFKP; PGAM1; GAPDH; TPI1; ENO2; SLC2A3; HMGB1; PKM; MPI; ALDOA; ALDOC; PMAIP1; GPI; ATF4
GO:0070661 leukocyte proliferation 3.11 4.19e-06 1.23e-04 20/111 TNFRSF4; PTPRC; NDFIP1; CD74; HLA-DMB; HLA-DPA1; HLA-DPB1; RPS6; GSTP1; RPS3; IL2RA; PTPN6; HMGB1; GPR183; CORO1A; PYCARD; CCL5; ADA; CD79A; MIF
GO:0050920 regulation of chemotaxis 3.08 1.21e-03 1.61e-02 10/56 CD74; GPSM3; CORO1B; GSTP1; HMGB1; GPR183; CCL1; CCL5; MIF; DDT
GO:0042110 T cell activation 3.06 2.27e-10 2.77e-08 38/214 TNFRSF18; TNFRSF4; LCK; PTPRC; ZFP36L2; CD8A; CD8B; DPP4; NDFIP1; CD74; HLA-DMB; HLA-DPA1; HLA-DPB1; RPS6; SIT1; FUT7; CD5; RPS3; CD3D; CD3G; IL2RA; GATA3; CD27; LAG3; PTPN6; HMGB1; LCP1; GPR183; CORO1A; PYCARD; CYLD; CCL5; CD7; FKBP1A; SIRPG; ADA; LGALS1; SOD1
GO:0050867 positive regulation of cell activation 3.04 4.00e-07 1.83e-05 25/142 TNFRSF4; LCK; PTPRC; DPP4; CD74; HLA-DMB; HLA-DPA1; HLA-DPB1; CD5; RPS3; IL2RA; GATA3; CD27; PTPN6; HMGB1; GPR183; CORO1A; PYCARD; CYLD; CCL5; SIRPG; ADA; MIF; LGALS1; ITGB2
GO:0001906 cell killing 3.03 1.39e-03 1.73e-02 10/57 SLAMF7; PTPRC; HSP90AB1; RPL30; GAPDH; LAG3; PTPN6; GZMB; CTSH; CORO1A
GO:0007159 leukocyte cell-cell adhesion 3.02 1.46e-07 8.25e-06 27/154 LCK; PTPRC; DPP4; NDFIP1; CD74; ADTRP; HLA-DMB; HLA-DPA1; HLA-DPB1; CD44; CD5; RPS3; IL2RA; GATA3; CD27; LAG3; PTPN6; HMGB1; CORO1A; PYCARD; CYLD; CCL5; PECAM1; SIRPG; ADA; LGALS1; ITGB2
GO:0048872 homeostasis of number of cells 3.02 3.90e-06 1.19e-04 21/120 TNFRSF4; ATPIF1; CD74; RPS14; TSC22D3; MFHAS1; RPS6; SIT1; IL2RA; GATA3; RPS24; HMGB1; GPR183; RPS17; CORO1A; CYLD; PMAIP1; ADA; GPI; MIF; SOD1
GO:0045785 positive regulation of cell adhesion 2.97 3.66e-07 1.79e-05 26/151 TNFRSF18; LCK; S100A10; PTPRC; DPP4; CD74; HLA-DMB; HLA-DPA1; HLA-DPB1; NINJ1; CD44; CD5; RPS3; IL2RA; GATA3; SPOCK2; CD27; PTPN6; HMGB1; CORO1A; PYCARD; CYLD; CCL5; SIRPG; ADA; LGALS1
GO:0060326 cell chemotaxis 2.95 3.57e-04 6.39e-03 13/76 CD74; GPSM3; CXCR3; CORO1B; GSTP1; HMGB1; GPR183; CORO1A; CCL1; CCL5; MIF; DDT; ITGB2
GO:0070482 response to oxygen levels 2.85 3.62e-06 1.15e-04 23/139 ENO1; LMNA; EGLN1; RPS27A; DPP4; FAM162A; NAMPT; HILPDA; PGK1; BNIP3L; LDHA; DDIT4; BNIP3; ERO1A; PKM; TCEB2; ALKBH5; P4HB; PMAIP1; ADA; ATF4; MT-ND4; MT-ND5
GO:0034341 response to interferon-gamma 2.84 3.21e-04 5.88e-03 14/85 CD58; HLA-DRA; HLA-DRB5; HLA-DRB1; HLA-DQA1; HLA-DPA1; HLA-DPB1; HSP90AB1; CD44; VIM; GAPDH; CCL1; CCL5; RPL13A
GO:0016053 organic acid biosynthetic process 2.75 1.11e-05 2.84e-04 22/138 ENO1; PGM1; INSIG2; CD74; INSIG1; PGK1; LDHA; FADS2; FADS1; PFKP; DDIT4; PGAM1; SCD; GAPDH; TPI1; ENO2; BCAT1; PKM; ALDOA; ALDOC; GPI; MIF
GO:0022407 regulation of cell-cell adhesion 2.75 2.78e-06 9.72e-05 25/157 LCK; PTPRC; DPP4; NDFIP1; CD74; ADTRP; HLA-DMB; HLA-DPA1; HLA-DPB1; CD44; CD5; RPS3; IL2RA; GATA3; CD27; LAG3; PTPN6; HMGB1; CORO1A; PYCARD; CYLD; CCL5; SIRPG; ADA; LGALS1
GO:0050663 cytokine secretion 2.74 3.03e-03 3.13e-02 10/63 TNFRSF4; CD58; LCP2; GATA3; SRGN; GAPDH; HMGB1; PYCARD; CCL1; MIF
GO:0032102 negative regulation of response to external stimulus 2.72 1.25e-03 1.64e-02 12/76 PTPRC; NDFIP1; ADTRP; MFHAS1; CORO1B; GSTP1; IL2RA; GATA3; PYCARD; ADA; MIF; DDT
GO:0016051 carbohydrate biosynthetic process 2.67 2.32e-03 2.66e-02 11/71 ENO1; PGM1; PGK1; PGAM1; GAPDH; TPI1; ENO2; ALDOA; ALDOC; GPI; ATF4
GO:0034612 response to tumor necrosis factor 2.67 4.01e-04 6.69e-03 15/97 TNFRSF18; TNFRSF4; CD58; ZFP36L2; TAX1BP1; GSTP1; RPS3; BIRC3; GATA3; CD27; PYCARD; CYLD; CCL1; CCL5; CD70
GO:0002694 regulation of leukocyte activation 2.64 2.62e-07 1.37e-05 32/209 TNFRSF18; TNFRSF4; LCK; PTPRC; ZFP36L2; DPP4; NDFIP1; CD74; HLA-DMB; HLA-DPA1; HLA-DPB1; MFHAS1; SIT1; CD5; RPS3; IL2RA; GATA3; CD27; LAG3; PTPN6; HMGB1; GPR183; CORO1A; PYCARD; CYLD; CCL5; SIRPG; ADA; MIF; LGALS1; SOD1; ITGB2
GO:0002285 lymphocyte activation involved in immune response 2.60 2.91e-03 3.05e-02 11/73 PTPRC; NDFIP1; HLA-DMB; RPS6; GATA3; HMGB1; LCP1; GPR183; CORO1A; ADA; LGALS1
GO:0019882 antigen processing and presentation 2.56 6.25e-04 9.39e-03 15/101 CAPZB; CD8A; CD74; HLA-DRA; HLA-DRB5; HLA-DRB1; HLA-DQA1; PSMB8; HLA-DMB; HLA-DPA1; HLA-DPB1; LAG3; CTSH; PYCARD; KIF3B
GO:0050727 regulation of inflammatory response 2.56 6.25e-04 9.39e-03 15/101 PTPRC; NDFIP1; GPSM3; MFHAS1; GSTP1; BIRC3; IL2RA; GATA3; PYCARD; CYLD; CCL1; CCL5; ADA; DDT; ITGB2
GO:0072522 purine-containing compound biosynthetic process 2.54 1.35e-04 2.99e-03 19/129 ENO1; AK2; PGM1; GUK1; PAICS; PGK1; LDHA; PFKP; DDIT4; PGAM1; SCD; GAPDH; TPI1; ENO2; PKM; ALDOA; ALDOC; ADA; GPI
GO:0008637 apoptotic mitochondrial changes 2.54 5.33e-03 4.67e-02 10/68 ATPIF1; JUN; LMNA; FAM162A; TNFSF10; BNIP3L; BNIP3; GZMB; PYCARD; PMAIP1
GO:0051271 negative regulation of cellular component movement 2.50 4.01e-03 3.77e-02 11/76 ADTRP; TIMP1; CORO1B; GSTP1; GATA3; HMGB1; ACTN1; IDH2; ADA; MIF; DDT
GO:0009123 nucleoside monophosphate metabolic process 2.49 3.44e-06 1.15e-04 29/201 ENO1; ATPIF1; AK2; NDUFS5; PGM1; GUK1; NDUFB4; PAICS; PGK1; LDHA; PFKP; DDIT4; PGAM1; NDUFB8; GAPDH; TPI1; ENO2; PKM; ALDOA; ALDOC; TK1; ADA; GPI; MT-ND1; MT-ND2; MT-CO1; MT-CO3; MT-ND4; MT-ND5
GO:0051188 cofactor biosynthetic process 2.48 1.84e-04 3.64e-03 19/132 ENO1; ATPIF1; PGM1; NAMPT; PGK1; LDHA; PFKP; DDIT4; PGAM1; SCD; GAPDH; TPI1; ENO2; PKM; IDH2; ALDOA; ALDOC; GPI; SOD1
GO:0044282 small molecule catabolic process 2.46 6.40e-05 1.47e-03 22/154 ENO1; PGM1; ADTRP; ACAT2; PGK1; FUT7; CD44; PFKP; ENTPD1; PGAM1; GAPDH; TPI1; ENO2; BCAT1; PKM; ALDOA; BCKDK; ALDOC; ADA; GPI; TYMP; CBR3
GO:0001818 negative regulation of cytokine production 2.46 1.39e-03 1.73e-02 14/98 TNFRSF4; PTPRC; CD96; NDFIP1; HSP90AB1; TAX1BP1; GSTP1; GATA3; SRGN; LAG3; PTPN6; HMGB1; PYCARD; CYLD
GO:0009141 nucleoside triphosphate metabolic process 2.44 1.12e-05 2.84e-04 27/191 ENO1; ATPIF1; AK2; NDUFS5; PGM1; GUK1; NDUFB4; PGK1; LDHA; PFKP; DDIT4; PGAM1; NDUFB8; GAPDH; TPI1; ENO2; PKM; ALDOA; ALDOC; ADA; GPI; MT-ND1; MT-ND2; MT-CO1; MT-CO3; MT-ND4; MT-ND5
GO:0046390 ribose phosphate biosynthetic process 2.41 4.01e-04 6.69e-03 18/129 ENO1; AK2; PGM1; GUK1; PAICS; PGK1; LDHA; PFKP; DDIT4; PGAM1; SCD; GAPDH; TPI1; ENO2; PKM; ALDOA; ALDOC; GPI
GO:0072507 divalent inorganic cation homeostasis 2.39 4.42e-04 7.20e-03 18/130 CD52; LCK; PTPRC; CCDC109B; CXCR3; BNIP3; PTPN6; HMGB1; ERO1A; GPR65; CORO1A; CCL1; CCL5; FKBP1A; GNA15; PTGIR; ATF4; SMDT1
GO:0002449 lymphocyte mediated immunity 2.37 2.06e-03 2.40e-02 14/102 SLAMF7; PTPRC; CD8A; CD96; NDFIP1; CD74; GATA3; CD27; LAG3; PTPN6; HMGB1; GZMB; CTSH; CORO1A
GO:2001233 regulation of apoptotic signaling pathway 2.36 2.95e-05 6.98e-04 26/190 TNFRSF4; ENO1; RPL11; ATPIF1; LCK; MCL1; LMNA; PTPRC; RPS7; FAM162A; TNFSF10; CSF2; CD74; CD44; GSTP1; RPS3; BNIP3; GZMB; CTSH; PYCARD; CYLD; RPL26; P4HB; PMAIP1; MIF; SOD1
GO:0002764 immune response-regulating signaling pathway 2.36 1.01e-05 2.74e-04 29/212 LCK; JUN; RAP1A; ARPC5; PTPRC; RPS27A; LCP2; HLA-DRA; HLA-DRB5; HLA-DRB1; HLA-DQA1; HLA-DPA1; HLA-DPB1; HSP90AB1; ARPC1B; MFHAS1; RPS3; BIRC3; CD3D; CD3G; GATA3; PTPN6; HMGB1; PRKCH; CTSH; CYLD; ADA; CD79A; ITGB2
GO:0006909 phagocytosis 2.35 4.45e-03 4.08e-02 12/88 RAP1A; ARPC5; PTPRC; HSP90AB1; ARPC1B; CD3G; HMGB1; CORO1A; PYCARD; PECAM1; SIRPG; ITGB2
GO:0046677 response to antibiotic 2.35 7.83e-04 1.13e-02 17/125 JUN; TXNIP; EEF1B2; ANKZF1; TXN; LDHA; GSTP1; RPS3; GATA3; BNIP3; CD27; VKORC1; RPL23; ADA; SOD1; MT-ND4; MT-ND5
GO:1901293 nucleoside phosphate biosynthetic process 2.33 1.52e-04 3.22e-03 22/163 ENO1; AK2; PGM1; GUK1; PAICS; NAMPT; PGK1; LDHA; PFKP; DDIT4; PGAM1; SCD; GAPDH; TPI1; ENO2; PKM; IDH2; ALDOA; ALDOC; TK1; ADA; GPI
GO:0008202 steroid metabolic process 2.30 5.36e-03 4.67e-02 12/90 FDPS; INSIG2; HMGCS1; ACAT2; INSIG1; EBP; FDFT1; SQLE; DHCR7; SCD; LIMA1; SOD1
GO:0051235 maintenance of location 2.25 2.41e-03 2.68e-02 15/115 LCK; PTPRC; TMSB10; SKP1; HILPDA; INSIG1; PLIN2; TXN; SRGN; PTPN6; ERO1A; SYNE2; CORO1A; FKBP1A; FTL
GO:0002250 adaptive immune response 2.23 7.41e-04 1.09e-02 19/147 SLAMF7; PTPRC; CD8A; CD8B; NDFIP1; CD74; SIT1; CD3D; CD3G; GATA3; CD27; PTPN6; HMGB1; GPR183; CTSH; PYCARD; CD7; ADA; CD79A
GO:0006732 coenzyme metabolic process 2.23 5.52e-04 8.79e-03 20/155 ENO1; PGM1; HMGCS1; NAMPT; PGK1; LDHA; PFKP; DDIT4; PGAM1; SCD; GAPDH; TPI1; ENO2; SLC2A3; PKM; IDH2; ALDOA; ALDOC; GPI; CBR3
GO:0018212 peptidyl-tyrosine modification 2.18 4.54e-03 4.11e-02 14/111 TNFRSF18; LCK; PTPRC; CBLB; CSF2; CD74; CD44; PTPN6; CCL5; ABI3; PECAM1; MIF; TPST2; ITGB2
GO:1901615 organic hydroxy compound metabolic process 2.16 2.02e-03 2.40e-02 17/136 FDPS; INSIG2; HMGCS1; ACAT2; INSIG1; EBP; FDFT1; SQLE; LDHA; DHCR7; GATA3; SCD; TPI1; LIMA1; DDT; SOD1; ITGB2
GO:0007015 actin filament organization 2.16 2.72e-03 2.93e-02 16/128 CAPZB; S100A10; ARPC5; TMSB10; ARPC1B; CFL1; CORO1B; LIMA1; LCP1; ACTN1; GPR65; MSRB1; ALDOA; CORO1A; PYCARD; PFN1
GO:0097193 intrinsic apoptotic signaling pathway 2.14 9.02e-04 1.25e-02 20/161 ENO1; RPL11; LCK; MCL1; RPS7; CD74; CD44; RPS3; DDIT4; BNIP3; ERO1A; PYCARD; CYLD; RPL26; DDX5; P4HB; PMAIP1; MIF; ATF4; SOD1
GO:0002521 leukocyte differentiation 2.13 2.21e-04 4.27e-03 25/202 TNFRSF18; LCK; JUN; PTPRC; BATF3; ZFP36L2; CD8A; CSF2; NDFIP1; CD74; RPS6; FUT7; CD3D; CD3G; IL2RA; GATA3; CD27; PTPN6; HMGB1; GPR183; CYLD; ADA; CD79A; LGALS1; SOD1
GO:0002791 regulation of peptide secretion 2.12 2.37e-03 2.67e-02 17/138 TNFRSF4; RAP1A; CD58; DPP4; CD74; ADTRP; RAB11FIP1; GATA3; SRGN; GAPDH; HMGB1; IDH2; PYCARD; CCL1; CCL5; GPI; MIF
GO:0062012 regulation of small molecule metabolic process 2.12 3.19e-03 3.25e-02 16/130 ENO1; ATPIF1; FDPS; INSIG2; HMGCS1; INSIG1; FDFT1; SQLE; DHCR7; DDIT4; PGAM1; SCD; HMGB1; PMAIP1; OAZ1; SOD1
GO:0001819 positive regulation of cytokine production 2.10 1.14e-03 1.55e-02 20/164 CD58; PTPRC; CSF2; CD74; DDX41; GPSM3; HLA-DPA1; HLA-DPB1; HILPDA; RPS3; BIRC3; GATA3; GAPDH; HMGB1; PYCARD; CCL1; MIF; DDT; ATF4; SOD1
GO:0070997 neuron death 2.09 3.72e-03 3.67e-02 16/132 JUN; MCL1; EGLN1; FAM162A; HSP90AB1; NAMPT; GATA3; DDIT4; BNIP3; GAPDH; CORO1A; CCL5; GPI; ATF4; SOD1; ITGB2
GO:0006091 generation of precursor metabolites and energy 2.04 1.54e-04 3.22e-03 29/245 ENO1; ATPIF1; NDUFS5; PGM1; NDUFB4; PPP1R2; PGK1; PRKCDBP; LDHA; PFKP; DDIT4; PGAM1; NDUFB8; BNIP3; GAPDH; TPI1; ENO2; HMGB1; PKM; IDH2; ALDOA; ALDOC; GPI; MT-ND1; MT-ND2; MT-CO1; MT-CO3; MT-ND4; MT-ND5
GO:0002697 regulation of immune effector process 2.01 4.30e-03 3.99e-02 17/146 TNFRSF4; RAP1A; PTPRC; CD96; NDFIP1; CD74; HLA-DMB; BIRC3; IL2RA; GATA3; LAG3; PTPN6; HMGB1; PYCARD; GPI; MIF; ITGB2
GO:0009259 ribonucleotide metabolic process 2.01 1.63e-04 3.31e-03 30/258 ENO1; ATPIF1; AK2; NDUFS5; PGM1; GUK1; NDUFB4; PAICS; HMGCS1; PGK1; LDHA; PFKP; DDIT4; PGAM1; SCD; NDUFB8; GAPDH; TPI1; ENO2; PKM; ALDOA; ALDOC; GPI; TPST2; MT-ND1; MT-ND2; MT-CO1; MT-CO3; MT-ND4; MT-ND5
Summary:
Marker ARID1A CBLB CD3D CD5 LCP2 RASA2 TCEB2
Signif_GO_terms 48 46 86 74 132 46 79

4.2 Reactome Pathway Over-Representation Analysis

Gene sets: The Reactome pathway database.

ARID1A : 43 significant Reactome pathways
GeneSet description enrichRatio pValue FDR GeneRatio geneSymbols
R-HSA-202430 Translocation of ZAP-70 to Immunological synapse 17.80 3.26e-08 4.12e-06 7/14 HLA-DRA; HLA-DRB5; HLA-DRB1; HLA-DQA1; HLA-DQB1; HLA-DPA1; HLA-DPB1
R-HSA-375276 Peptide ligand-binding receptors 16.70 5.96e-08 5.87e-06 7/15 XCL2; CXCR4; CXCL10; CXCR3; ANXA1; CCL1; CCR7
R-HSA-389948 PD-1 signaling 16.70 5.96e-08 5.87e-06 7/15 HLA-DRA; HLA-DRB5; HLA-DRB1; HLA-DQA1; HLA-DQB1; HLA-DPA1; HLA-DPB1
R-HSA-202427 Phosphorylation of CD3 and TCR zeta chains 15.60 1.04e-07 9.18e-06 7/16 HLA-DRA; HLA-DRB5; HLA-DRB1; HLA-DQA1; HLA-DQB1; HLA-DPA1; HLA-DPB1
R-HSA-5607763 CLEC7A (Dectin-1) induces NFAT activation 14.30 1.08e-04 3.66e-03 4/10 ITPR1; CALM1; NFATC3
R-HSA-202433 Generation of second messenger molecules 13.40 6.99e-09 1.03e-06 9/24 HLA-DRA; HLA-DRB5; HLA-DRB1; HLA-DQA1; HLA-DQB1; HLA-DPA1; HLA-DPB1; EVL; VASP
R-HSA-877300 Interferon gamma signaling 12.40 2.28e-14 2.02e-11 16/46 STAT1; IRF1; IRF4; HLA-F; HLA-A; HLA-E; HLA-C; HLA-B; HLA-DRA; HLA-DRB5; HLA-DRB1; HLA-DQA1; HLA-DQB1; HLA-DPA1; HLA-DPB1; CD44
R-HSA-983170 Antigen Presentation: Folding, assembly and peptide loading of class I MHC 11.30 8.49e-06 3.58e-04 6/19 HLA-F; HLA-A; HLA-E; HLA-C; HLA-B; TAP1
R-HSA-373076 Class A/1 (Rhodopsin-like receptors) 10.60 4.17e-07 2.64e-05 8/27 XCL2; CXCR4; CXCL10; PTGER4; CXCR3; ANXA1; CCL1; CCR7
R-HSA-198933 Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell 10.30 3.18e-09 5.76e-07 11/38 SELL; CD8A; CD96; HLA-F; HLA-A; HLA-E; HLA-C; HLA-B; CD99; ITGB7; HCST
R-HSA-1489509 DAG and IP3 signaling 10.20 4.70e-04 1.26e-02 4/14 ITPR1; PRKAR1B; CALM1
R-HSA-216083 Integrin cell surface interactions 10.20 4.70e-04 1.26e-02 4/14 ITGA1; CD44; ITGB7; PECAM1
R-HSA-418360 Platelet calcium homeostasis 10.20 4.70e-04 1.26e-02 4/14 ITPR1; ATP2B1; CALM1
R-HSA-909733 Interferon alpha/beta signaling 10.00 1.24e-07 1.00e-05 9/32 STAT1; IRF1; IRF4; HLA-F; HLA-A; HLA-E; HLA-C; HLA-B; IFITM2
R-HSA-112040 G-protein mediated events 8.40 1.05e-03 2.44e-02 4/17 ITPR1; PRKAR1B; CALM1
R-HSA-112043 PLC beta mediated events 8.40 1.05e-03 2.44e-02 4/17 ITPR1; PRKAR1B; CALM1
R-HSA-5578775 Ion homeostasis 7.93 1.32e-03 2.91e-02 4/18 ITPR1; ATP2B1; CALM1
R-HSA-445355 Smooth Muscle Contraction 7.93 1.32e-03 2.91e-02 4/18 ITGA1; ANXA1; CALM1
R-HSA-500792 GPCR ligand binding 7.71 5.74e-06 2.54e-04 8/37 XCL2; CXCR4; CXCL10; PTGER4; CXCR3; ANXA1; CCL1; CCR7
R-HSA-2871809 FCERI mediated Ca+2 mobilization 7.51 1.63e-03 3.45e-02 4/19 ITPR1; CALM1; NFATC3
R-HSA-114608 Platelet degranulation 6.69 5.12e-06 2.39e-04 9/48 TUBA4A; TIMP1; FAM49B; CTSW; CD63; ACTN1; CALM1; PECAM1
R-HSA-1474244 Extracellular matrix organization 6.57 6.87e-05 2.54e-03 7/38 ITGA1; TIMP1; CTSD; CD44; ITGB7; ACTN1; PECAM1
R-HSA-418594 G alpha (i) signalling events 6.30 2.47e-07 1.82e-05 12/68 RGS1; CXCR4; ITPR1; CXCL10; GPSM3; PRKAR1B; CXCR3; ANXA1; CALM1; CCL1; CCR7
R-HSA-76005 Response to elevated platelet cytosolic Ca2+ 6.18 1.02e-05 3.94e-04 9/52 TUBA4A; TIMP1; FAM49B; CTSW; CD63; ACTN1; CALM1; PECAM1
R-HSA-388841 Costimulation by the CD28 family 5.95 1.34e-04 4.09e-03 7/42 HLA-DRA; HLA-DRB5; HLA-DRB1; HLA-DQA1; HLA-DQB1; HLA-DPA1; HLA-DPB1
R-HSA-202733 Cell surface interactions at the vascular wall 5.95 1.34e-04 4.09e-03 7/42 SELL; CD74; CD99; DOK2; CD44; PECAM1; SIRPG
R-HSA-913531 Interferon Signaling 5.67 3.25e-09 5.76e-07 17/107 STAT1; IRF1; IRF4; HLA-F; HLA-A; HLA-E; HLA-C; HLA-B; HLA-DRA; HLA-DRB5; HLA-DRB1; HLA-DQA1; HLA-DQB1; HLA-DPA1; HLA-DPB1; IFITM2; CD44
R-HSA-6785807 Interleukin-4 and Interleukin-13 signaling 5.63 5.60e-04 1.46e-02 6/38 STAT1; IRF4; FSCN1; TIMP1; ANXA1; JUNB
R-HSA-418346 Platelet homeostasis 5.57 1.73e-03 3.57e-02 5/32 ITPR1; ATP2B1; CALM1; PECAM1
R-HSA-2132295 MHC class II antigen presentation 5.45 3.60e-06 1.77e-04 11/72 TUBA4A; CD74; HLA-DRA; HLA-DRB5; HLA-DRB1; HLA-DQA1; HLA-DQB1; HLA-DMB; HLA-DPA1; HLA-DPB1; CTSD
R-HSA-397014 Muscle contraction 5.22 8.52e-04 2.16e-02 6/41 ITPR1; ITGA1; ANXA1; ATP2B1; CALM1
R-HSA-202424 Downstream TCR signaling 4.97 9.14e-06 3.68e-04 11/79 HLA-DRA; HLA-DRB5; HLA-DRB1; HLA-DQA1; HLA-DQB1; PSMB9; HLA-DPA1; HLA-DPB1; PSME1; PSME2; NFKBIA
R-HSA-202403 TCR signaling 4.88 1.61e-06 9.54e-05 13/95 HLA-DRA; HLA-DRB5; HLA-DRB1; HLA-DQA1; HLA-DQB1; PSMB9; HLA-DPA1; HLA-DPB1; PSME1; PSME2; NFKBIA; EVL; VASP
R-HSA-1236974 ER-Phagosome pathway 4.72 9.42e-05 3.34e-03 9/68 HLA-F; HLA-A; HLA-E; HLA-C; HLA-B; PSMB9; TAP1; PSME1; PSME2
R-HSA-1236975 Antigen processing-Cross presentation 4.46 1.48e-04 4.38e-03 9/72 HLA-F; HLA-A; HLA-E; HLA-C; HLA-B; PSMB9; TAP1; PSME1; PSME2
R-HSA-388396 GPCR downstream signalling 4.15 2.02e-06 1.12e-04 15/129 RHOC; XCL2; RGS1; CXCR4; ITPR1; CXCL10; PTGER4; GPSM3; PRKAR1B; CXCR3; ANXA1; CALM1; CCL1; CCR7
R-HSA-372790 Signaling by GPCR 4.09 2.46e-06 1.28e-04 15/131 RHOC; XCL2; RGS1; CXCR4; ITPR1; CXCL10; PTGER4; GPSM3; PRKAR1B; CXCR3; ANXA1; CALM1; CCL1; CCR7
R-HSA-76002 Platelet activation, signaling and aggregation 3.77 1.26e-04 4.09e-03 11/104 TUBA4A; ITPR1; TIMP1; FAM49B; CTSW; CD63; ACTN1; CALM1; PECAM1; RAC2
R-HSA-5607764 CLEC7A (Dectin-1) signaling 3.66 1.35e-03 2.91e-02 8/78 ITPR1; PSMB9; PSME1; PSME2; NFKBIA; CALM1; NFATC3
R-HSA-109582 Hemostasis 3.50 2.67e-07 1.82e-05 21/214 SELL; TUBA4A; ITPR1; ITGA1; IRF1; CD74; PRKAR1B; CD99; TIMP1; DOK2; FAM49B; CD44; CTSW; CD63; ATP2B1; ACTN1; CALM1; PECAM1; SIRPG; RAC2
R-HSA-1280215 Cytokine Signaling in Immune system 3.39 3.68e-10 1.63e-07 31/326 PTPN7; STAT1; CXCL10; IRF1; IRF4; HLA-F; HLA-A; HLA-E; HLA-C; HLA-B; HLA-DRA; HLA-DRB5; HLA-DRB1; HLA-DQA1; HLA-DQB1; PSMB9; HLA-DPA1; HLA-DPB1; FSCN1; TIMP1; ANXA1; IFITM2; CD44; BIRC3; IL2RA; PSME1; PSME2; NFKBIA; IL16; LGALS9; JUNB
R-HSA-1280218 Adaptive Immune System 3.06 6.97e-10 2.06e-07 34/397 SELL; CD8A; TUBA4A; ITPR1; CD96; SIAH2; CD74; HLA-F; HLA-A; HLA-E; HLA-C; HLA-B; HLA-DRA; HLA-DRB5; HLA-DRB1; HLA-DQA1; HLA-DQB1; PSMB9; TAP1; HLA-DMB; HLA-DPA1; HLA-DPB1; CD99; CTSD; ITGB7; PSME1; PSME2; NFKBIA; CALM1; EVL; NFATC3; HCST; VASP
R-HSA-449147 Signaling by Interleukins 2.47 8.96e-04 2.20e-02 15/217 PTPN7; STAT1; CXCL10; IRF4; PSMB9; FSCN1; TIMP1; ANXA1; IL2RA; PSME1; PSME2; NFKBIA; IL16; LGALS9; JUNB
CBLB : 54 significant Reactome pathways
GeneSet description enrichRatio pValue FDR GeneRatio geneSymbols
R-HSA-156902 Peptide chain elongation 6.82 0.00e+00 0.00e+00 67/85 RPL22; RPS8; RPL5; RPS7; RPS27A; RPL31; RPL37A; RPL32; RPL14; RPL29; RPL24; RPL22L1; RPL35A; RPL9; RPL34; RPS3A; RPL37; RPS23; RPS14; RPS18; RPS10; RPL10A; RPS12; RPL36A; RPL39; RPS20; RPL7; RPL30; RPL8; RPS6; RPL35; RPL12; RPL7A; RPL27A; RPS13; RPS25; RPS24; RPS26; RPL41; RPL6; RPLP0; RPL21; RPS29; RPL4; RPLP1; RPS17; RPS2; RPS15A; RPL13; RPL26; RPL23A; RPL23; RPL19; RPL27; RPL38; RPL17; RPS21; RPS15; RPL36; RPL18A; UBA52; RPS16; RPL18; RPL13A; RPS9; RPS5; RPL3
R-HSA-192823 Viral mRNA Translation 6.82 0.00e+00 0.00e+00 67/85 RPL22; RPS8; RPL5; RPS7; RPS27A; RPL31; RPL37A; RPL32; RPL14; RPL29; RPL24; RPL22L1; RPL35A; RPL9; RPL34; RPS3A; RPL37; RPS23; RPS14; RPS18; RPS10; RPL10A; RPS12; RPL36A; RPL39; RPS20; RPL7; RPL30; RPL8; RPS6; RPL35; RPL12; RPL7A; RPL27A; RPS13; RPS25; RPS24; RPS26; RPL41; RPL6; RPLP0; RPL21; RPS29; RPL4; RPLP1; RPS17; RPS2; RPS15A; RPL13; RPL26; RPL23A; RPL23; RPL19; RPL27; RPL38; RPL17; RPS21; RPS15; RPL36; RPL18A; UBA52; RPS16; RPL18; RPL13A; RPS9; RPS5; RPL3
R-HSA-2408557 Selenocysteine synthesis 6.82 0.00e+00 0.00e+00 67/85 RPL22; RPS8; RPL5; RPS7; RPS27A; RPL31; RPL37A; RPL32; RPL14; RPL29; RPL24; RPL22L1; RPL35A; RPL9; RPL34; RPS3A; RPL37; RPS23; RPS14; RPS18; RPS10; RPL10A; RPS12; RPL36A; RPL39; RPS20; RPL7; RPL30; RPL8; RPS6; RPL35; RPL12; RPL7A; RPL27A; RPS13; RPS25; RPS24; RPS26; RPL41; RPL6; RPLP0; RPL21; RPS29; RPL4; RPLP1; RPS17; RPS2; RPS15A; RPL13; RPL26; RPL23A; RPL23; RPL19; RPL27; RPL38; RPL17; RPS21; RPS15; RPL36; RPL18A; UBA52; RPS16; RPL18; RPL13A; RPS9; RPS5; RPL3
R-HSA-156842 Eukaryotic Translation Elongation 6.76 0.00e+00 0.00e+00 68/87 RPL22; RPS8; RPL5; RPS7; RPS27A; RPL31; EEF1B2; RPL37A; RPL32; RPL14; RPL29; RPL24; RPL22L1; RPL35A; RPL9; RPL34; RPS3A; RPL37; RPS23; RPS14; RPS18; RPS10; RPL10A; RPS12; RPL36A; RPL39; RPS20; RPL7; RPL30; RPL8; RPS6; RPL35; RPL12; RPL7A; RPL27A; RPS13; RPS25; RPS24; RPS26; RPL41; RPL6; RPLP0; RPL21; RPS29; RPL4; RPLP1; RPS17; RPS2; RPS15A; RPL13; RPL26; RPL23A; RPL23; RPL19; RPL27; RPL38; RPL17; RPS21; RPS15; RPL36; RPL18A; UBA52; RPS16; RPL18; RPL13A; RPS9; RPS5; RPL3
R-HSA-975956 Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) 6.71 0.00e+00 0.00e+00 69/89 RPL22; RPS8; RPL5; RPS7; RPS27A; RPL31; RPL37A; RPL32; RPL14; RPL29; RPL24; RPL22L1; EIF4G1; RPL35A; RPL9; RPL34; RPS3A; RPL37; RPS23; ETF1; RPS14; RPS18; RPS10; RPL10A; RPS12; RPL36A; RPL39; RPS20; RPL7; RPL30; RPL8; RPS6; RPL35; RPL12; RPL7A; RPL27A; RPS13; RPS25; RPS24; RPS26; RPL41; RPL6; RPLP0; RPL21; RPS29; RPL4; RPLP1; RPS17; RPS2; RPS15A; RPL13; RPL26; RPL23A; RPL23; RPL19; RPL27; RPL38; RPL17; RPS21; RPS15; RPL36; RPL18A; UBA52; RPS16; RPL18; RPL13A; RPS9; RPS5; RPL3
R-HSA-72764 Eukaryotic Translation Termination 6.69 0.00e+00 0.00e+00 68/88 RPL22; RPS8; RPL5; RPS7; RPS27A; RPL31; RPL37A; RPL32; RPL14; RPL29; RPL24; RPL22L1; RPL35A; RPL9; RPL34; RPS3A; RPL37; RPS23; ETF1; RPS14; RPS18; RPS10; RPL10A; RPS12; RPL36A; RPL39; RPS20; RPL7; RPL30; RPL8; RPS6; RPL35; RPL12; RPL7A; RPL27A; RPS13; RPS25; RPS24; RPS26; RPL41; RPL6; RPLP0; RPL21; RPS29; RPL4; RPLP1; RPS17; RPS2; RPS15A; RPL13; RPL26; RPL23A; RPL23; RPL19; RPL27; RPL38; RPL17; RPS21; RPS15; RPL36; RPL18A; UBA52; RPS16; RPL18; RPL13A; RPS9; RPS5; RPL3
R-HSA-72689 Formation of a pool of free 40S subunits 6.40 0.00e+00 0.00e+00 71/96 RPL22; RPS8; RPL5; RPS7; RPS27A; RPL31; RPL37A; RPL32; RPL14; RPL29; RPL24; RPL22L1; RPL35A; RPL9; RPL34; RPS3A; RPL37; RPS23; RPS14; RPS18; RPS10; RPL10A; RPS12; EIF1AX; RPL36A; RPL39; RPS20; RPL7; RPL30; RPL8; RPS6; RPL35; RPL12; RPL7A; EIF3F; RPL27A; RPS13; EIF3M; RPS25; RPS24; RPS26; RPL41; RPL6; RPLP0; RPL21; RPS29; RPL4; RPLP1; RPS17; RPS2; RPS15A; RPL13; RPL26; RPL23A; RPL23; RPL19; RPL27; RPL38; RPL17; RPS21; RPS15; RPL36; RPL18A; UBA52; EIF3K; RPS16; RPL18; RPL13A; RPS9; RPS5; RPL3
R-HSA-202430 Translocation of ZAP-70 to Immunological synapse 6.18 2.51e-07 6.54e-06 10/14 LCK; HLA-DRA; HLA-DRB5; HLA-DRB1; HLA-DQA1; HLA-DQB1; HLA-DPA1; HLA-DPB1; CD3D; CD3G
R-HSA-72706 GTP hydrolysis and joining of the 60S ribosomal subunit 5.99 0.00e+00 0.00e+00 74/107 RPL22; RPS8; RPL5; RPS7; RPS27A; EIF5B; RPL31; RPL37A; RPL32; RPL14; RPL29; RPL24; RPL22L1; EIF4G1; RPL35A; RPL9; RPL34; RPS3A; RPL37; RPS23; RPS14; RPS18; RPS10; RPL10A; RPS12; EIF1AX; RPL36A; RPL39; RPS20; RPL7; RPL30; RPL8; RPS6; RPL35; RPL12; RPL7A; EIF3F; RPL27A; RPS13; EIF3M; RPS25; RPS24; RPS26; RPL41; RPL6; RPLP0; RPL21; RPS29; RPL4; RPLP1; RPS17; RPS2; RPS15A; RPL13; RPL26; RPL23A; RPL23; RPL19; RPL27; RPL38; RPL17; EIF2S2; RPS21; RPS15; RPL36; RPL18A; UBA52; EIF3K; RPS16; RPL18; RPL13A; RPS9; RPS5; RPL3
R-HSA-156827 L13a-mediated translational silencing of Ceruloplasmin expression 5.96 0.00e+00 0.00e+00 73/106 RPL22; RPS8; RPL5; RPS7; RPS27A; RPL31; RPL37A; RPL32; RPL14; RPL29; RPL24; RPL22L1; EIF4G1; RPL35A; RPL9; RPL34; RPS3A; RPL37; RPS23; RPS14; RPS18; RPS10; RPL10A; RPS12; EIF1AX; RPL36A; RPL39; RPS20; RPL7; RPL30; RPL8; RPS6; RPL35; RPL12; RPL7A; EIF3F; RPL27A; RPS13; EIF3M; RPS25; RPS24; RPS26; RPL41; RPL6; RPLP0; RPL21; RPS29; RPL4; RPLP1; RPS17; RPS2; RPS15A; RPL13; RPL26; RPL23A; RPL23; RPL19; RPL27; RPL38; RPL17; EIF2S2; RPS21; RPS15; RPL36; RPL18A; UBA52; EIF3K; RPS16; RPL18; RPL13A; RPS9; RPS5; RPL3
R-HSA-202427 Phosphorylation of CD3 and TCR zeta chains 5.95 1.11e-07 2.98e-06 11/16 LCK; PTPRC; HLA-DRA; HLA-DRB5; HLA-DRB1; HLA-DQA1; HLA-DQB1; HLA-DPA1; HLA-DPB1; CD3D; CD3G
R-HSA-2408522 Selenoamino acid metabolism 5.94 0.00e+00 0.00e+00 68/99 RPL22; RPS8; RPL5; RPS7; RPS27A; RPL31; RPL37A; RPL32; RPL14; RPL29; RPL24; RPL22L1; RPL35A; RPL9; RPL34; RPS3A; RPL37; RPS23; RPS14; EEF1E1; RPS18; RPS10; RPL10A; RPS12; RPL36A; RPL39; RPS20; RPL7; RPL30; RPL8; RPS6; RPL35; RPL12; RPL7A; RPL27A; RPS13; RPS25; RPS24; RPS26; RPL41; RPL6; RPLP0; RPL21; RPS29; RPL4; RPLP1; RPS17; RPS2; RPS15A; RPL13; RPL26; RPL23A; RPL23; RPL19; RPL27; RPL38; RPL17; RPS21; RPS15; RPL36; RPL18A; UBA52; RPS16; RPL18; RPL13A; RPS9; RPS5; RPL3
R-HSA-389948 PD-1 signaling 5.77 6.76e-07 1.66e-05 10/15 LCK; HLA-DRA; HLA-DRB5; HLA-DRB1; HLA-DQA1; HLA-DQB1; HLA-DPA1; HLA-DPB1; CD3D; CD3G
R-HSA-927802 Nonsense-Mediated Decay (NMD) 5.63 0.00e+00 0.00e+00 69/106 RPL22; RPS8; RPL5; RPS7; RPS27A; RPL31; RPL37A; RPL32; RPL14; RPL29; RPL24; RPL22L1; EIF4G1; RPL35A; RPL9; RPL34; RPS3A; RPL37; RPS23; ETF1; RPS14; RPS18; RPS10; RPL10A; RPS12; RPL36A; RPL39; RPS20; RPL7; RPL30; RPL8; RPS6; RPL35; RPL12; RPL7A; RPL27A; RPS13; RPS25; RPS24; RPS26; RPL41; RPL6; RPLP0; RPL21; RPS29; RPL4; RPLP1; RPS17; RPS2; RPS15A; RPL13; RPL26; RPL23A; RPL23; RPL19; RPL27; RPL38; RPL17; RPS21; RPS15; RPL36; RPL18A; UBA52; RPS16; RPL18; RPL13A; RPS9; RPS5; RPL3
R-HSA-975957 Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) 5.63 0.00e+00 0.00e+00 69/106 RPL22; RPS8; RPL5; RPS7; RPS27A; RPL31; RPL37A; RPL32; RPL14; RPL29; RPL24; RPL22L1; EIF4G1; RPL35A; RPL9; RPL34; RPS3A; RPL37; RPS23; ETF1; RPS14; RPS18; RPS10; RPL10A; RPS12; RPL36A; RPL39; RPS20; RPL7; RPL30; RPL8; RPS6; RPL35; RPL12; RPL7A; RPL27A; RPS13; RPS25; RPS24; RPS26; RPL41; RPL6; RPLP0; RPL21; RPS29; RPL4; RPLP1; RPS17; RPS2; RPS15A; RPL13; RPL26; RPL23A; RPL23; RPL19; RPL27; RPL38; RPL17; RPS21; RPS15; RPL36; RPL18A; UBA52; RPS16; RPL18; RPL13A; RPS9; RPS5; RPL3
R-HSA-72613 Eukaryotic Translation Initiation 5.62 0.00e+00 0.00e+00 74/114 RPL22; RPS8; RPL5; RPS7; RPS27A; EIF5B; RPL31; RPL37A; RPL32; RPL14; RPL29; RPL24; RPL22L1; EIF4G1; RPL35A; RPL9; RPL34; RPS3A; RPL37; RPS23; RPS14; RPS18; RPS10; RPL10A; RPS12; EIF1AX; RPL36A; RPL39; RPS20; RPL7; RPL30; RPL8; RPS6; RPL35; RPL12; RPL7A; EIF3F; RPL27A; RPS13; EIF3M; RPS25; RPS24; RPS26; RPL41; RPL6; RPLP0; RPL21; RPS29; RPL4; RPLP1; RPS17; RPS2; RPS15A; RPL13; RPL26; RPL23A; RPL23; RPL19; RPL27; RPL38; RPL17; EIF2S2; RPS21; RPS15; RPL36; RPL18A; UBA52; EIF3K; RPS16; RPL18; RPL13A; RPS9; RPS5; RPL3
R-HSA-72737 Cap-dependent Translation Initiation 5.62 0.00e+00 0.00e+00 74/114 RPL22; RPS8; RPL5; RPS7; RPS27A; EIF5B; RPL31; RPL37A; RPL32; RPL14; RPL29; RPL24; RPL22L1; EIF4G1; RPL35A; RPL9; RPL34; RPS3A; RPL37; RPS23; RPS14; RPS18; RPS10; RPL10A; RPS12; EIF1AX; RPL36A; RPL39; RPS20; RPL7; RPL30; RPL8; RPS6; RPL35; RPL12; RPL7A; EIF3F; RPL27A; RPS13; EIF3M; RPS25; RPS24; RPS26; RPL41; RPL6; RPLP0; RPL21; RPS29; RPL4; RPLP1; RPS17; RPS2; RPS15A; RPL13; RPL26; RPL23A; RPL23; RPL19; RPL27; RPL38; RPL17; EIF2S2; RPS21; RPS15; RPL36; RPL18A; UBA52; EIF3K; RPS16; RPL18; RPL13A; RPS9; RPS5; RPL3
R-HSA-1799339 SRP-dependent cotranslational protein targeting to membrane 5.50 0.00e+00 0.00e+00 68/107 RPL22; RPS8; RPL5; RPS7; RPS27A; RPL31; RPL37A; RPL32; RPL14; RPL29; RPL24; RPL22L1; RPL35A; RPL9; RPL34; RPS3A; RPL37; RPS23; RPS14; RPS18; RPS10; RPL10A; RPS12; RPL36A; RPL39; RPS20; RPL7; RPL30; RPL8; RPS6; SEC61B; RPL35; RPL12; RPL7A; RPL27A; RPS13; RPS25; RPS24; RPS26; RPL41; RPL6; RPLP0; RPL21; RPS29; RPL4; RPLP1; RPS17; RPS2; RPS15A; RPL13; RPL26; RPL23A; RPL23; RPL19; RPL27; RPL38; RPL17; RPS21; RPS15; RPL36; RPL18A; UBA52; RPS16; RPL18; RPL13A; RPS9; RPS5; RPL3
R-HSA-72695 Formation of the ternary complex, and subsequently, the 43S complex 5.23 4.44e-16 1.36e-14 29/48 RPS8; RPS7; RPS27A; RPS3A; RPS23; RPS14; RPS18; RPS10; RPS12; EIF1AX; RPS20; RPS6; EIF3F; RPS13; EIF3M; RPS25; RPS24; RPS26; RPS29; RPS17; RPS2; RPS15A; EIF2S2; RPS21; RPS15; EIF3K; RPS16; RPS9; RPS5
R-HSA-168273 Influenza Viral RNA Transcription and Replication 4.94 0.00e+00 0.00e+00 69/121 RPL22; RPS8; RPL5; RPS7; RPS27A; RPL31; RPL37A; RPL32; RPL14; RPL29; RPL24; RPL22L1; RPL35A; RPL9; RPL34; RPS3A; RPL37; RPS23; RPS14; RPS18; RPS10; RPL10A; RPS12; RPL36A; RPL39; RPS20; RPL7; RPL30; POLR2K; RPL8; RPS6; RPL35; RPL12; RPL7A; RPL27A; RPS13; RPS25; RPS24; RPS26; RPL41; RPL6; RPLP0; RPL21; RPS29; HSP90AA1; RPL4; RPLP1; RPS17; RPS2; RPS15A; RPL13; RPL26; RPL23A; RPL23; RPL19; RPL27; RPL38; RPL17; RPS21; RPS15; RPL36; RPL18A; UBA52; RPS16; RPL18; RPL13A; RPS9; RPS5; RPL3
R-HSA-168255 Influenza Life Cycle 4.79 0.00e+00 0.00e+00 72/130 RPL22; RPS8; RPL5; RPS7; RPS27A; RPL31; RPL37A; RPL32; RPL14; RPL29; RPL24; RPL22L1; RPL35A; RPL9; RPL34; RPS3A; RPL37; RPS23; RPS14; RPS18; RPS10; RPL10A; RPS12; RPL36A; RPL39; RPS20; RPL7; RPL30; POLR2K; RPL8; RPS6; RPL35; RPL12; RPL7A; RPL27A; RPS13; RPS25; RPS24; RPS26; RPL41; RPL6; RPLP0; RAN; RPL21; RPS29; HSP90AA1; RPL4; RPLP1; RPS17; RPS2; RPS15A; RPL13; RPL26; RPL23A; RPL23; RPL19; RPL27; KPNB1; RPL38; RPL17; RPS21; RPS15; RPL36; CALR; RPL18A; UBA52; RPS16; RPL18; RPL13A; RPS9; RPS5; RPL3
R-HSA-72649 Translation initiation complex formation 4.72 6.00e-15 1.71e-13 30/55 RPS8; RPS7; RPS27A; EIF4G1; RPS3A; RPS23; RPS14; RPS18; RPS10; RPS12; EIF1AX; RPS20; RPS6; EIF3F; RPS13; EIF3M; RPS25; RPS24; RPS26; RPS29; RPS17; RPS2; RPS15A; EIF2S2; RPS21; RPS15; EIF3K; RPS16; RPS9; RPS5
R-HSA-72702 Ribosomal scanning and start codon recognition 4.72 6.00e-15 1.71e-13 30/55 RPS8; RPS7; RPS27A; EIF4G1; RPS3A; RPS23; RPS14; RPS18; RPS10; RPS12; EIF1AX; RPS20; RPS6; EIF3F; RPS13; EIF3M; RPS25; RPS24; RPS26; RPS29; RPS17; RPS2; RPS15A; EIF2S2; RPS21; RPS15; EIF3K; RPS16; RPS9; RPS5
R-HSA-202433 Generation of second messenger molecules 4.69 4.15e-07 1.05e-05 13/24 LCK; FYB; HLA-DRA; HLA-DRB5; HLA-DRB1; HLA-DQA1; HLA-DQB1; HLA-DPA1; HLA-DPB1; CD3D; CD3G; EVL; GRAP2
R-HSA-72662 Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S 4.64 1.14e-14 3.17e-13 30/56 RPS8; RPS7; RPS27A; EIF4G1; RPS3A; RPS23; RPS14; RPS18; RPS10; RPS12; EIF1AX; RPS20; RPS6; EIF3F; RPS13; EIF3M; RPS25; RPS24; RPS26; RPS29; RPS17; RPS2; RPS15A; EIF2S2; RPS21; RPS15; EIF3K; RPS16; RPS9; RPS5
R-HSA-168254 Influenza Infection 4.48 0.00e+00 0.00e+00 72/139 RPL22; RPS8; RPL5; RPS7; RPS27A; RPL31; RPL37A; RPL32; RPL14; RPL29; RPL24; RPL22L1; RPL35A; RPL9; RPL34; RPS3A; RPL37; RPS23; RPS14; RPS18; RPS10; RPL10A; RPS12; RPL36A; RPL39; RPS20; RPL7; RPL30; POLR2K; RPL8; RPS6; RPL35; RPL12; RPL7A; RPL27A; RPS13; RPS25; RPS24; RPS26; RPL41; RPL6; RPLP0; RAN; RPL21; RPS29; HSP90AA1; RPL4; RPLP1; RPS17; RPS2; RPS15A; RPL13; RPL26; RPL23A; RPL23; RPL19; RPL27; KPNB1; RPL38; RPL17; RPS21; RPS15; RPL36; CALR; RPL18A; UBA52; RPS16; RPL18; RPL13A; RPS9; RPS5; RPL3
R-HSA-844456 The NLRP3 inflammasome 4.33 3.09e-03 4.81e-02 5/10 TXNIP; HSP90AB1; TXN; NFKB2; PYCARD
R-HSA-5669034 TNFs bind their physiological receptors 4.33 3.09e-03 4.81e-02 5/10 TNFRSF18; TNFRSF4; TNFRSF9; CD70; TNFSF14
R-HSA-9010553 Regulation of expression of SLITs and ROBOs 4.30 0.00e+00 0.00e+00 73/147 RPL22; RPS8; RPL5; RPS7; RPS27A; RPL31; RPL37A; RPL32; RPL14; RPL29; RPL24; RPL22L1; EIF4G1; RPL35A; RPL9; RPL34; RPS3A; RPL37; RPS23; ETF1; RPS14; PSMB8; PSMB9; RPS18; RPS10; RPL10A; RPS12; RPL36A; RPL39; RPS20; RPL7; RPL30; RPL8; RPS6; RPL35; RPL12; RPL7A; RPL27A; RPS13; RPS25; RPS24; RPS26; RPL41; RPL6; RPLP0; RPL21; PSME1; RPS29; RPL4; RPLP1; RPS17; RPS2; RPS15A; RPL13; RPL26; RPL23A; RPL23; RPL19; RPL27; RPL38; RPL17; PSMA7; RPS21; RPS15; RPL36; RPL18A; UBA52; RPS16; RPL18; RPL13A; RPS9; RPS5; RPL3
R-HSA-6791226 Major pathway of rRNA processing in the nucleolus and cytosol 4.05 0.00e+00 0.00e+00 74/158 RPL22; EBNA1BP2; RPS8; RPL5; RPS7; WDR43; RPS27A; RPL31; RPL37A; NCL; RPL32; RPL14; RPL29; GNL3; RPL24; RPL22L1; RPL35A; RPL9; RPL34; RPS3A; RPL37; RPS23; RPS14; RPS18; RPS10; RPL10A; RPS12; RPL36A; RPL39; RPS20; RPL7; RPL30; BOP1; RPL8; RPS6; RPL35; RPL12; RPL7A; RPL27A; RPS13; RPS25; DDX21; RPS24; RPS26; RPL41; RPL6; RPLP0; RPL21; RPS29; RPL4; RPLP1; RPS17; RPS2; RPS15A; RPL13; RPL26; RPL23A; RPL23; RPL19; RPL27; RPL38; RPL17; NOP56; RPS21; RPS15; RPL36; RPL18A; UBA52; RPS16; RPL18; RPL13A; RPS9; RPS5; RPL3
R-HSA-8862803 Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models 4.04 7.36e-04 1.45e-02 7/15 JUN; LMNA; CAPN2; CAST; YWHAE; CDC25B; PRDX2
R-HSA-8863678 Neurodegenerative Diseases 4.04 7.36e-04 1.45e-02 7/15 JUN; LMNA; CAPN2; CAST; YWHAE; CDC25B; PRDX2
R-HSA-622312 Inflammasomes 3.99 1.94e-03 3.43e-02 6/13 TXNIP; HSP90AB1; TXN; NFKB2; PYCARD; BCL2L1
R-HSA-376176 Signaling by ROBO receptors 3.99 0.00e+00 0.00e+00 77/167 RPL22; CAP1; RPS8; RPL5; RPS7; RPS27A; RPL31; RPL37A; RPL32; RPL14; RPL29; RPL24; RPL22L1; EIF4G1; RPL35A; RPL9; RPL34; RPS3A; RPL37; RPS23; ETF1; RPS14; PSMB8; PSMB9; RPS18; RPS10; RPL10A; RPS12; RPL36A; RPL39; RPS20; RPL7; RPL30; RPL8; RPS6; RPL35; RPL12; RPL7A; RPL27A; RPS13; RPS25; RPS24; NELL2; RPS26; RPL41; RPL6; RPLP0; RPL21; PSME1; RPS29; EVL; RPL4; RPLP1; RPS17; RPS2; RPS15A; RPL13; PFN1; RPL26; RPL23A; RPL23; RPL19; RPL27; RPL38; RPL17; PSMA7; RPS21; RPS15; RPL36; RPL18A; UBA52; RPS16; RPL18; RPL13A; RPS9; RPS5; RPL3
R-HSA-8868773 rRNA processing in the nucleus and cytosol 3.92 0.00e+00 0.00e+00 76/168 RPL22; EBNA1BP2; RPS8; RPL5; RPS7; WDR43; RPS27A; RPL31; RPL37A; NCL; RPL32; RPL14; RPL29; GNL3; RPL24; RPL22L1; RPL35A; RPL9; RPL34; RPS3A; RPL37; RPS23; RPS14; NHP2; RPS18; RPS10; RPL10A; RPS12; RPL36A; RPL39; DKC1; RPS20; RPL7; RPL30; BOP1; RPL8; RPS6; RPL35; RPL12; RPL7A; RPL27A; RPS13; RPS25; DDX21; RPS24; RPS26; RPL41; RPL6; RPLP0; RPL21; RPS29; RPL4; RPLP1; RPS17; RPS2; RPS15A; RPL13; RPL26; RPL23A; RPL23; RPL19; RPL27; RPL38; RPL17; NOP56; RPS21; RPS15; RPL36; RPL18A; UBA52; RPS16; RPL18; RPL13A; RPS9; RPS5; RPL3
R-HSA-72312 rRNA processing 3.76 0.00e+00 0.00e+00 76/175 RPL22; EBNA1BP2; RPS8; RPL5; RPS7; WDR43; RPS27A; RPL31; RPL37A; NCL; RPL32; RPL14; RPL29; GNL3; RPL24; RPL22L1; RPL35A; RPL9; RPL34; RPS3A; RPL37; RPS23; RPS14; NHP2; RPS18; RPS10; RPL10A; RPS12; RPL36A; RPL39; DKC1; RPS20; RPL7; RPL30; BOP1; RPL8; RPS6; RPL35; RPL12; RPL7A; RPL27A; RPS13; RPS25; DDX21; RPS24; RPS26; RPL41; RPL6; RPLP0; RPL21; RPS29; RPL4; RPLP1; RPS17; RPS2; RPS15A; RPL13; RPL26; RPL23A; RPL23; RPL19; RPL27; RPL38; RPL17; NOP56; RPS21; RPS15; RPL36; RPL18A; UBA52; RPS16; RPL18; RPL13A; RPS9; RPS5; RPL3
R-HSA-198933 Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell 3.64 1.53e-06 3.66e-05 16/38 SELL; CD8B; ITGA4; HLA-A; HLA-E; HLA-C; HLA-B; SH2D1A; CD3D; CD3G; CRTAM; KLRD1; B2M; HCST; LAIR1; LAIR2
R-HSA-983170 Antigen Presentation: Folding, assembly and peptide loading of class I MHC 3.64 7.08e-04 1.45e-02 8/19 HLA-A; HLA-E; HLA-C; HLA-B; TAP1; HSPA5; B2M; CALR
R-HSA-3928662 EPHB-mediated forward signaling 3.46 1.06e-03 1.96e-02 8/20 ARPC5; ARPC2; FYN; ACTB; ARPC1B; CFL1; ARPC3; ACTG1
R-HSA-71291 Metabolism of amino acids and derivatives 3.39 0.00e+00 0.00e+00 83/212 RPL22; SRM; RPS8; RPL5; PHGDH; RPS7; ODC1; RPS27A; RPL31; RPL37A; RPL32; RPL14; RPL29; RPL24; RPL22L1; RPL35A; RPL9; RPL34; RPS3A; RPL37; SERINC5; RPS23; RPS14; EEF1E1; PSMB8; PSMB9; RPS18; RPS10; RPL10A; RPS12; SMS; RPL36A; RPL39; RPS20; RPL7; RPL30; RPL8; RPS6; PSAT1; RPL35; RPL12; RPL7A; RPL27A; RPS13; SLC3A2; RPS25; RPS24; RPS26; RPL41; RPL6; RPLP0; RPL21; PSME1; RPS29; RPL4; RPLP1; RPS17; RPS2; RPS15A; NDUFAB1; GCSH; RPL13; RPL26; RPL23A; RPL23; RPL19; RPL27; RPL38; PYCR1; RPL17; PSMA7; RPS21; RPS15; OAZ1; RPL36; RPL18A; UBA52; RPS16; RPL18; RPL13A; RPS9; RPS5; RPL3
R-HSA-422475 Axon guidance 3.23 0.00e+00 0.00e+00 96/257 RPL22; CAP1; RPS8; RPL5; ARPC5; PTPRC; RPS7; SPTBN1; RPS27A; RPL31; RPL37A; ARPC2; RPL32; RPL14; RPL29; RPL24; SIAH2; RPL22L1; EIF4G1; RPL35A; RPL9; RPL34; RPS3A; RPL37; RPS23; ETF1; RPS14; PSMB8; PSMB9; RPS18; RPS10; RPL10A; HSP90AB1; FYN; RPS12; ACTB; ARPC1B; RPL36A; RPL39; RPS20; RPL7; RPL30; RPL8; RPS6; RPL35; RPL12; RPL7A; RPL27A; RPS13; CFL1; RPS25; ANK3; RPS24; ABLIM1; NELL2; RPS26; RPL41; MYL6; ARPC3; RPL6; RPLP0; RPL21; PSME1; RPS29; EVL; HSP90AA1; RPL4; RPLP1; RPS17; RPS2; RPS15A; RPL13; PFN1; RPL26; RPL23A; RPL23; RPL19; RPL27; RPL38; ACTG1; MYL12A; RPL17; PSMA7; RPS21; RPS15; RPL36; RPL18A; UBA52; RPS16; AP2S1; RPL18; RPL13A; RPS9; RPS5; MYH9; RPL3
R-HSA-388841 Costimulation by the CD28 family 3.09 3.51e-05 7.78e-04 15/42 LCK; CD28; HLA-DRA; HLA-DRB5; HLA-DRB1; HLA-DQA1; HLA-DQB1; HLA-DPA1; HLA-DPB1; FYN; CD3D; CD3G; MAP3K8; PPP2R5C; GRAP2
R-HSA-877300 Interferon gamma signaling 3.01 2.82e-05 6.40e-04 16/46 STAT1; HLA-A; HLA-E; HLA-C; HLA-B; HLA-DRA; HLA-DRB5; HLA-DRB1; HLA-DQA1; HLA-DQB1; HLA-DPA1; HLA-DPB1; CD44; IFNG; B2M; MT2A
R-HSA-373755 Semaphorin interactions 3.01 3.02e-03 4.81e-02 8/23 PTPRC; HSP90AB1; FYN; CFL1; MYL6; HSP90AA1; MYL12A; MYH9
R-HSA-72766 Translation 2.94 0.00e+00 0.00e+00 90/265 MRPL20; RPL22; RPS8; RPL5; RPS7; RPS27A; EIF5B; RPL31; EEF1B2; RPL37A; RPL32; RPL14; RPL29; RPL24; MRPL3; RPL22L1; EIF4G1; RPL35A; RPL9; RPL34; RPS3A; RPL37; RPS23; ETF1; RPS14; EEF1E1; RPS18; RPS10; RPL10A; RPS12; EIF1AX; RPL36A; RPL39; RPS20; RPL7; RPL30; RPL8; RPS6; SEC61B; RPL35; RPL12; RPL7A; CARS; MRPL17; EIF3F; RPL27A; RPS13; EIF3M; MRPL11; RPS25; PPA1; RPS24; RPS26; RPL41; RPL6; RPLP0; RPL21; RPS29; WARS; RPL4; RPLP1; RPS17; MRPS34; RPS2; RPS15A; RPL13; RPL26; RPL23A; RPL23; RPL19; RPL27; RPL38; MRPL12; RPL17; EIF2S2; RPS21; RPS15; RPL36; MRPL4; GADD45GIP1; RPL18A; UBA52; EIF3K; MRPS12; RPS16; RPL18; RPL13A; RPS9; RPS5; RPL3
R-HSA-2682334 EPH-Ephrin signaling 2.73 7.86e-04 1.51e-02 12/38 ARPC5; ARPC2; FYN; ACTB; ARPC1B; CFL1; MYL6; ARPC3; ACTG1; MYL12A; AP2S1; MYH9
R-HSA-5663205 Infectious disease 2.66 0.00e+00 0.00e+00 94/306 RPL22; LCK; RPS8; RPL5; RPS7; RPS27A; CD8B; RPL31; CD28; RPL37A; RPL32; RPL14; RPL29; RPL24; RPL22L1; RPL35A; RPL9; RPL34; RPS3A; RPL37; RPS23; SKP1; RPS14; NPM1; PSMB8; PSMB9; RPS18; RPS10; RPL10A; HSP90AB1; FYN; RPS12; RPL36A; SLC25A5; RPL39; RPS20; RPL7; RPL30; POLR2K; RPL8; RPS6; RPL35; RPL12; RPL7A; RPL27A; RPS13; SSRP1; RPS25; NMT2; RPS24; CD9; RPS26; RPL41; RPL6; RPLP0; RAN; RPL21; PSME1; RPS29; CALM1; HSP90AA1; B2M; RPL4; RPLP1; RPS17; RPS2; RPS15A; RPL13; RPL26; MAP2K3; RPL23A; RPL23; RPL19; RPL27; KPNB1; RPL38; RPL17; PSMA7; RPS21; RPS15; RPL36; CALR; RPL18A; UBA52; RPS16; AP2S1; RPL18; RPL13A; RPS9; RPS5; CHMP2A; RANBP1; RPL3
R-HSA-2029482 Regulation of actin dynamics for phagocytic cup formation 2.57 2.24e-03 3.82e-02 11/37 ARPC5; ARPC2; HSP90AB1; ACTB; ARPC1B; CFL1; CD3G; ARPC3; HSP90AA1; ACTG1; MYH9
R-HSA-1266738 Developmental Biology 2.57 0.00e+00 0.00e+00 105/354 RPL22; CAP1; RPS8; JUN; RPL5; ARPC5; PTPRC; H3F3A; RPS7; SPTBN1; RPS27A; RPL31; RPL37A; ARPC2; RPL32; RPL14; RPL29; RPL24; SIAH2; RPL22L1; EIF4G1; RPL35A; RBPJ; RPL9; RPL34; RPS3A; RPL37; RPS23; ETF1; RPS14; PSMB8; PSMB9; RPS18; RPS10; RPL10A; CCND3; HSP90AB1; FYN; RPS12; ACTB; H2AFV; ARPC1B; RPL36A; RPL39; RPS20; RPL7; RPL30; POLR2K; RPL8; RPS6; RPL35; RPL12; RPL7A; RPL27A; RPS13; CFL1; EED; RPS25; ANK3; RPS24; ABLIM1; NELL2; RPS26; RPL41; MYL6; CDK4; ARPC3; RPL6; RPLP0; RPL21; PSME1; RPS29; EVL; HSP90AA1; RPL4; RPLP1; RPS17; RPS2; RPS15A; RPL13; PFN1; RPL26; RPL23A; RPL23; RPL19; RPL27; RPL38; H3F3B; ACTG1; MYL12A; RPL17; PSMA7; RPS21; RPS15; RPL36; RPL18A; UBA52; RPS16; AP2S1; RPL18; RPL13A; RPS9; RPS5; MYH9; RPL3
R-HSA-2029480 Fcgamma receptor (FCGR) dependent phagocytosis 2.36 3.20e-03 4.90e-02 12/44 ARPC5; ARPC2; HSP90AB1; FYN; ACTB; ARPC1B; CFL1; CD3G; ARPC3; HSP90AA1; ACTG1; MYH9
R-HSA-114608 Platelet degranulation 2.34 2.34e-03 3.91e-02 13/48 CAP1; MANF; WDR1; FAM3C; TMSB4X; FLNA; HSPA5; CFL1; SRGN; CD9; CALM1; PFN1
R-HSA-913531 Interferon Signaling 2.10 1.36e-04 2.95e-03 26/107 RPS27A; STAT1; EIF4G1; ABCE1; HLA-A; HLA-E; HLA-C; HLA-B; HLA-DRA; HLA-DRB5; HLA-DRB1; HLA-DQA1; HLA-DQB1; PSMB8; HLA-DPA1; HLA-DPB1; FLNA; EIF4G2; CD44; IFNG; B2M; ISG20; MT2A; KPNB1; SAMHD1; UBA52
R-HSA-202403 TCR signaling 2.10 3.51e-04 7.40e-03 23/95 LCK; PTPRC; RPS27A; TRAT1; FYB; SKP1; HLA-DRA; HLA-DRB5; HLA-DRB1; HLA-DQA1; HLA-DQB1; PSMB8; PSMB9; HLA-DPA1; HLA-DPB1; CD3D; CD3G; PSME1; NFKBIA; EVL; PSMA7; UBA52; GRAP2
R-HSA-202424 Downstream TCR signaling 2.08 1.23e-03 2.23e-02 19/79 LCK; RPS27A; TRAT1; SKP1; HLA-DRA; HLA-DRB5; HLA-DRB1; HLA-DQA1; HLA-DQB1; PSMB8; PSMB9; HLA-DPA1; HLA-DPB1; CD3D; CD3G; PSME1; NFKBIA; PSMA7; UBA52
CD3D : 14 significant Reactome pathways
GeneSet description enrichRatio pValue FDR GeneRatio geneSymbols
R-HSA-5669034 TNFs bind their physiological receptors 10.60 4.54e-05 3.67e-03 5/10 TNFRSF18; TNFRSF4; TNFRSF9; CD70; TNFSF14
R-HSA-6783783 Interleukin-10 signaling 8.50 3.51e-05 3.45e-03 6/15 CSF2; CCL3; CCL4; CCL3L3; CCL4L2
R-HSA-8862803 Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models 7.08 4.46e-04 2.82e-02 5/15 PRDX1; JUN; LMNA; CAST; CDC25B
R-HSA-8863678 Neurodegenerative Diseases 7.08 4.46e-04 2.82e-02 5/15 PRDX1; JUN; LMNA; CAST; CDC25B
R-HSA-373076 Class A/1 (Rhodopsin-like receptors) 6.30 2.12e-05 2.34e-03 8/27 XCL2; XCL1; PTGER4; HRH2; CXCR3; CCL1; S1PR4; PTGIR
R-HSA-500792 GPCR ligand binding 5.74 4.77e-06 8.45e-04 10/37 XCL2; XCL1; RAMP1; PTGER4; HRH2; CXCR3; CCL1; S1PR4; ADGRE5; PTGIR
R-HSA-202733 Cell surface interactions at the vascular wall 5.06 1.64e-05 2.08e-03 10/42 LCK; CD58; CD2; FCER1G; SELL; GYPC; ITGA4; FYN; CD44; SELPLG
R-HSA-198933 Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell 4.47 2.99e-04 2.20e-02 8/38 SELL; CD8B; ITGA4; CD3G; CRTAM; KLRB1; KLRD1; LAIR2
R-HSA-418594 G alpha (i) signalling events 4.06 1.16e-05 1.71e-03 13/68 DHRS3; RGS1; ITPR1; CAMK4; CXCR3; RDH10; RGS10; CCL1; CCL4; CCL4L2; S1PR4; CALM3
R-HSA-372790 Signaling by GPCR 3.41 4.75e-07 1.70e-04 21/131 DHRS3; XCL2; XCL1; RGS1; RAMP1; ITPR1; PTGER4; CAMK4; HRH2; CXCR3; RDH10; RASGRP2; RGS10; CCL1; CCL4; CCL4L2; S1PR4; ADGRE5; CALM3; PTGIR
R-HSA-388396 GPCR downstream signalling 3.29 1.58e-06 3.49e-04 20/129 DHRS3; XCL2; XCL1; RGS1; RAMP1; ITPR1; PTGER4; CAMK4; HRH2; CXCR3; RDH10; RASGRP2; RGS10; CCL1; CCL4; CCL4L2; S1PR4; CALM3; PTGIR
R-HSA-449147 Signaling by Interleukins 2.74 5.74e-07 1.70e-04 28/217 LCK; JUN; PTPN7; IL7R; CSF2; PSMB8; FYN; IL2RG; DUSP4; IL2RA; GATA3; MAP3K8; NFKB2; IFNG; PSME1; NFKBIA; BATF; SOCS1; MAP2K3; CCL3; CCL4; CCL3L3; CCL4L2; BCL2L1; CNN2; JUNB; SOD1
R-HSA-1280215 Cytokine Signaling in Immune system 2.54 1.93e-08 1.71e-05 39/326 TNFRSF18; TNFRSF4; TNFRSF9; LCK; JUN; PTPN7; IL7R; CSF2; LTB; PSMB8; FYN; IL2RG; DUSP4; CD44; BIRC3; IL2RA; GATA3; MAP3K8; NFKB2; IFNG; PSME1; NFKBIA; BATF; ISG20; SOCS1; MT2A; MAP2K3; CCL3; CCL4; CCL3L3; CCL4L2; BCL2L1; SAMHD1; CNN2; CD70; TNFSF14; JUNB; SOD1
R-HSA-109582 Hemostasis 2.38 4.56e-05 3.67e-03 24/214 CAPZB; LCK; CD58; CD2; S100A10; FCER1G; SELL; GYPC; ITGA4; ITPR1; FYN; FAM3C; CD44; RASGRP2; GATA3; SRGN; CD9; SELPLG; PPP2R5C; H3F3B; KIF3B; CALM3; PTGIR; SOD1
CD5 : 12 significant Reactome pathways
GeneSet description enrichRatio pValue FDR GeneRatio geneSymbols
R-HSA-5669034 TNFs bind their physiological receptors 10.00 7.51e-06 0.002217 6/10 TNFRSF18; TNFRSF4; TNFRSF9; CD27; CD70; TNFSF14
R-HSA-8862803 Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models 6.66 1.39e-04 0.012275 6/15 PRDX1; JUN; LMNA; CAPN2; CAST; CDC25B
R-HSA-8863678 Neurodegenerative Diseases 6.66 1.39e-04 0.012275 6/15 PRDX1; JUN; LMNA; CAPN2; CAST; CDC25B
R-HSA-8876725 Protein methylation 6.41 6.45e-04 0.038076 5/13 EEF1A1; CALM1; RPS2; CALM3; ETFB
R-HSA-622312 Inflammasomes 6.41 6.45e-04 0.038076 5/13 TXNIP; HSP90AB1; NFKB2; PYCARD; BCL2L1
R-HSA-373076 Class A/1 (Rhodopsin-like receptors) 4.94 1.22e-04 0.012275 8/27 XCL2; XCL1; PTGER4; HRH2; CXCR3; CCL1; S1PR4; PTGIR
R-HSA-418555 G alpha (s) signalling events 4.67 4.84e-04 0.035755 7/25 RAMP1; PTGER4; HRH2; GRK6; PDE3B; ARRB2; PTGIR
R-HSA-500792 GPCR ligand binding 4.50 4.12e-05 0.007305 10/37 XCL2; XCL1; RAMP1; PTGER4; HRH2; CXCR3; CCL1; S1PR4; ADGRE5; PTGIR
R-HSA-372790 Signaling by GPCR 3.05 5.19e-07 0.000460 24/131 DHRS3; XCL2; XCL1; RGS1; RAMP1; ITPR1; PTGER4; CAMK4; HRH2; GRK6; CXCR3; RDH10; RGS3; PDE3B; RASGRP2; NMT2; CALM1; ARRB2; CCL1; RGS19; S1PR4; ADGRE5; CALM3; PTGIR
R-HSA-388396 GPCR downstream signalling 2.97 1.50e-06 0.000665 23/129 DHRS3; XCL2; XCL1; RGS1; RAMP1; ITPR1; PTGER4; CAMK4; HRH2; GRK6; CXCR3; RDH10; RGS3; PDE3B; RASGRP2; NMT2; CALM1; ARRB2; CCL1; RGS19; S1PR4; CALM3; PTGIR
R-HSA-418594 G alpha (i) signalling events 2.94 5.90e-04 0.038076 12/68 DHRS3; RGS1; ITPR1; CAMK4; CXCR3; RDH10; NMT2; CALM1; CCL1; RGS19; S1PR4; CALM3
R-HSA-109582 Hemostasis 2.26 2.00e-05 0.004420 29/214 CAPZB; LCK; CD2; S100A10; FCER1G; SELL; H3F3A; ITGA4; TUBA4A; ITPR1; FYN; FAM3C; DOK2; YWHAZ; PDE3B; RASGRP2; SRGN; CD9; TUBA1B; SELPLG; CALM1; PPP2R5C; ANXA2; ARRB2; H3F3B; KIF3B; CALM3; PTGIR; SOD1
LCP2 : 62 significant Reactome pathways
GeneSet description enrichRatio pValue FDR GeneRatio geneSymbols
R-HSA-198933 Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell 6.57 0.00e+00 0.00e+00 26/38 SLAMF7; SELL; ITGA4; CD96; HLA-A; HLA-E; HLA-C; HLA-B; NCR3; CD99; SH2D1A; NPDC1; CD81; CD3G; CRTAM; ITGB1; KLRB1; CLEC2B; KLRC1; ITGB7; B2M; ITGAL; HCST; LAIR1; LAIR2; ITGB2
R-HSA-373076 Class A/1 (Rhodopsin-like receptors) 5.69 6.39e-10 3.15e-08 16/27 XCL2; XCL1; PTGER4; HRH2; CXCR3; ANXA1; PMCH; LPAR6; GPR183; PTGER2; GPR68; CCL1; CCL5; CCR7; S1PR4; PTGIR
R-HSA-375276 Peptide ligand-binding receptors 5.12 4.31e-05 9.78e-04 8/15 XCL2; XCL1; CXCR3; ANXA1; PMCH; CCL1; CCL5; CCR7
R-HSA-216083 Integrin cell surface interactions 4.80 2.26e-04 3.86e-03 7/14 ITGA4; CD47; ITGB1; ITGB7; ITGAL; ITGB2; COL6A2
R-HSA-844456 The NLRP3 inflammasome 4.80 1.93e-03 2.56e-02 5/10 TXNIP; HSP90AB1; CASP1; NFKB2; PYCARD
R-HSA-500792 GPCR ligand binding 4.67 3.92e-09 1.83e-07 18/37 XCL2; XCL1; CD55; RAMP1; PTGER4; HRH2; CXCR3; ANXA1; PMCH; LPAR6; GPR183; PTGER2; GPR68; CCL1; CCL5; CCR7; S1PR4; PTGIR
R-HSA-2871809 FCERI mediated Ca+2 mobilization 4.55 4.71e-05 1.02e-03 9/19 FCER1G; ITPR1; TXK; CALM1; LAT; NFATC3; GRB2; GRAP2
R-HSA-2172127 DAP12 interactions 4.48 3.87e-04 6.12e-03 7/15 LCK; HLA-E; FYN; B2M; LAT; GRB2; GRAP2
R-HSA-2424491 DAP12 signaling 4.48 3.87e-04 6.12e-03 7/15 LCK; HLA-E; FYN; B2M; LAT; GRB2; GRAP2
R-HSA-622312 Inflammasomes 4.43 1.12e-03 1.57e-02 6/13 TXNIP; HSP90AB1; CASP1; NFKB2; PYCARD; BCL2L1
R-HSA-9008059 Interleukin-37 signaling 4.36 3.25e-03 3.99e-02 5/11 PTPN7; PTPN4; PTPN18; CASP1; PTPN6
R-HSA-202733 Cell surface interactions at the vascular wall 4.34 6.65e-09 2.68e-07 19/42 LCK; CD2; FCER1G; SELL; GYPC; ITGA4; INPP5D; CD47; FYN; CD99; DOK2; ITGB1; PTPN6; SELPLG; SPN; ITGAL; GRB2; TGFB1; ITGB2
R-HSA-983695 Antigen activates B Cell Receptor (BCR) leading to generation of second messengers 4.11 1.24e-04 2.29e-03 9/21 ITPR1; DAPP1; FYN; ORAI2; PTPN6; CALM1; GRB2; CD79A
R-HSA-418360 Platelet calcium homeostasis 4.11 1.78e-03 2.39e-02 6/14 ATP2B4; ITPR1; ORAI2; ATP2B1; CALM1
R-HSA-156842 Eukaryotic Translation Elongation 3.97 2.44e-14 1.08e-11 36/87 RPS8; RPL5; RPS7; RPS27A; EEF1B2; RPL37A; RPL32; RPL15; RPL9; RPS3A; RPS23; RPS18; RPL10A; EEF1A1; RPL7; RPL30; EEF1D; RPS6; RPL12; RPL7A; RPL27A; RPS13; RPS25; RPS24; RPL6; RPS29; RPL4; RPLP1; RPS17; RPL23A; RPL23; RPL19; RPL18A; RPS9; RPS5; RPL3
R-HSA-156902 Peptide chain elongation 3.84 4.39e-13 9.72e-11 34/85 RPS8; RPL5; RPS7; RPS27A; RPL37A; RPL32; RPL15; RPL9; RPS3A; RPS23; RPS18; RPL10A; EEF1A1; RPL7; RPL30; RPS6; RPL12; RPL7A; RPL27A; RPS13; RPS25; RPS24; RPL6; RPS29; RPL4; RPLP1; RPS17; RPL23A; RPL23; RPL19; RPL18A; RPS9; RPS5; RPL3
R-HSA-192823 Viral mRNA Translation 3.84 4.39e-13 9.72e-11 34/85 RPS8; RPL5; RPS7; RPS27A; RPL37A; RPL32; RPL15; RPL9; GRSF1; RPS3A; RPS23; RPS18; RPL10A; RPL7; RPL30; RPS6; RPL12; RPL7A; RPL27A; RPS13; RPS25; RPS24; RPL6; RPS29; RPL4; RPLP1; RPS17; RPL23A; RPL23; RPL19; RPL18A; RPS9; RPS5; RPL3
R-HSA-1474244 Extracellular matrix organization 3.79 2.31e-06 6.40e-05 15/38 CTSS; CAPN2; ITGA4; CD47; CAST; TIMP1; CTSD; ITGB1; ITGB7; ITGAL; P4HB; CAPN12; TGFB1; ITGB2; COL6A2
R-HSA-1474228 Degradation of the extracellular matrix 3.73 1.45e-03 2.00e-02 7/18 CTSS; CAPN2; CAST; TIMP1; CTSD; CAPN12; COL6A2
R-HSA-2408557 Selenocysteine synthesis 3.73 2.68e-12 3.95e-10 33/85 RPS8; RPL5; RPS7; RPS27A; RPL37A; RPL32; RPL15; RPL9; RPS3A; RPS23; RPS18; RPL10A; RPL7; RPL30; RPS6; RPL12; RPL7A; RPL27A; RPS13; RPS25; RPS24; RPL6; RPS29; RPL4; RPLP1; RPS17; RPL23A; RPL23; RPL19; RPL18A; RPS9; RPS5; RPL3
R-HSA-975956 Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) 3.67 2.12e-12 3.75e-10 34/89 RPS8; RPL5; RPS7; RPS27A; RPL37A; RPL32; RPL15; RPL9; RPS3A; RPS23; RPS18; RPL10A; RPL7; RPL30; PABPC1; RPS6; RPL12; RPL7A; RPL27A; RPS13; RPS25; RPS24; RPL6; RPS29; RPL4; RPLP1; RPS17; RPL23A; RPL23; RPL19; RPL18A; RPS9; RPS5; RPL3
R-HSA-72764 Eukaryotic Translation Termination 3.60 8.32e-12 1.05e-09 33/88 RPS8; RPL5; RPS7; RPS27A; RPL37A; RPL32; RPL15; RPL9; RPS3A; RPS23; RPS18; RPL10A; RPL7; RPL30; RPS6; RPL12; RPL7A; RPL27A; RPS13; RPS25; RPS24; RPL6; RPS29; RPL4; RPLP1; RPS17; RPL23A; RPL23; RPL19; RPL18A; RPS9; RPS5; RPL3
R-HSA-451927 Interleukin-2 family signaling 3.49 1.11e-03 1.57e-02 8/22 LCK; INPP5D; CSF2; IL2RA; PTPN6; IL21R; LGALS9; GRB2
R-HSA-418555 G alpha (s) signalling events 3.46 5.88e-04 9.14e-03 9/25 RAMP1; PTGER4; REEP5; HRH2; GRK6; PDE3B; PTGER2; ARRB2; PTGIR
R-HSA-400253 Circadian Clock 3.41 1.68e-04 2.97e-03 11/31 NCOA1; RPS27A; BHLHE40; TBL1XR1; SKP1; NR3C1; NAMPT; CREM; PPP1CC; HIF1A; RORA
R-HSA-72689 Formation of a pool of free 40S subunits 3.40 2.57e-11 2.84e-09 34/96 RPS8; RPL5; RPS7; RPS27A; RPL37A; RPL32; RPL15; RPL9; RPS3A; RPS23; RPS18; RPL10A; RPL7; RPL30; RPS6; RPL12; RPL7A; RPL27A; RPS13; RPS25; RPS24; RPL6; RPS29; RPL4; RPLP1; RPS17; RPL23A; RPL23; RPL19; RPL18A; EIF3K; RPS9; RPS5; RPL3
R-HSA-1799339 SRP-dependent cotranslational protein targeting to membrane 3.23 3.60e-11 3.54e-09 36/107 RPS8; RPL5; SSR2; RPS7; RPS27A; RPL37A; RPL32; RPL15; RPL9; RPS3A; RPS23; RPS18; RPL10A; RPL7; RPL30; RPS6; SEC61B; RPL12; RPL7A; RPL27A; RPS13; RPS25; RPS24; RPL6; RPS29; RPL4; RPLP1; RPS17; RPL23A; RPL23; RPL19; SEC11C; RPL18A; RPS9; RPS5; RPL3
R-HSA-2408522 Selenoamino acid metabolism 3.20 3.29e-10 1.94e-08 33/99 RPS8; RPL5; RPS7; RPS27A; RPL37A; RPL32; RPL15; RPL9; RPS3A; RPS23; RPS18; RPL10A; RPL7; RPL30; RPS6; RPL12; RPL7A; RPL27A; RPS13; RPS25; RPS24; RPL6; RPS29; RPL4; RPLP1; RPS17; RPL23A; RPL23; RPL19; RPL18A; RPS9; RPS5; RPL3
R-HSA-512988 Interleukin-3, Interleukin-5 and GM-CSF signaling 3.20 2.11e-03 2.71e-02 8/24 RPS27A; INPP5D; CSF2; FYN; YWHAZ; IL2RA; PTPN6; GRB2
R-HSA-156827 L13a-mediated translational silencing of Ceruloplasmin expression 3.17 1.25e-10 1.08e-08 35/106 RPS8; RPL5; RPS7; RPS27A; RPL37A; RPL32; RPL15; RPL9; RPS3A; RPS23; RPS18; RPL10A; RPL7; RPL30; PABPC1; RPS6; RPL12; RPL7A; RPL27A; RPS13; RPS25; RPS24; RPL6; RPS29; RPL4; RPLP1; RPS17; RPL23A; RPL23; RPL19; RPL18A; EIF3K; RPS9; RPS5; RPL3
R-HSA-72706 GTP hydrolysis and joining of the 60S ribosomal subunit 3.14 1.68e-10 1.24e-08 35/107 RPS8; RPL5; RPS7; RPS27A; EIF5B; RPL37A; RPL32; RPL15; RPL9; RPS3A; RPS23; RPS18; RPL10A; RPL7; RPL30; RPS6; RPL12; RPL7A; RPL27A; RPS13; RPS25; RPS24; RPL6; RPS29; RPL4; RPLP1; RPS17; RPL23A; RPL23; RPL19; RPL18A; EIF3K; RPS9; RPS5; RPL3
R-HSA-927802 Nonsense-Mediated Decay (NMD) 3.08 5.66e-10 2.95e-08 34/106 RPS8; RPL5; RPS7; RPS27A; RPL37A; RPL32; RPL15; RPL9; RPS3A; RPS23; RPS18; RPL10A; RPL7; RPL30; PABPC1; RPS6; RPL12; RPL7A; RPL27A; RPS13; RPS25; RPS24; RPL6; RPS29; RPL4; RPLP1; RPS17; RPL23A; RPL23; RPL19; RPL18A; RPS9; RPS5; RPL3
R-HSA-975957 Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) 3.08 5.66e-10 2.95e-08 34/106 RPS8; RPL5; RPS7; RPS27A; RPL37A; RPL32; RPL15; RPL9; RPS3A; RPS23; RPS18; RPL10A; RPL7; RPL30; PABPC1; RPS6; RPL12; RPL7A; RPL27A; RPS13; RPS25; RPS24; RPL6; RPS29; RPL4; RPLP1; RPS17; RPL23A; RPL23; RPL19; RPL18A; RPS9; RPS5; RPL3
R-HSA-72613 Eukaryotic Translation Initiation 3.03 2.80e-10 1.77e-08 36/114 RPS8; RPL5; RPS7; RPS27A; EIF5B; RPL37A; RPL32; RPL15; RPL9; RPS3A; RPS23; RPS18; RPL10A; RPL7; RPL30; PABPC1; RPS6; RPL12; RPL7A; RPL27A; RPS13; RPS25; RPS24; RPL6; RPS29; RPL4; RPLP1; RPS17; RPL23A; RPL23; RPL19; RPL18A; EIF3K; RPS9; RPS5; RPL3
R-HSA-72737 Cap-dependent Translation Initiation 3.03 2.80e-10 1.77e-08 36/114 RPS8; RPL5; RPS7; RPS27A; EIF5B; RPL37A; RPL32; RPL15; RPL9; RPS3A; RPS23; RPS18; RPL10A; RPL7; RPL30; PABPC1; RPS6; RPL12; RPL7A; RPL27A; RPS13; RPS25; RPS24; RPL6; RPS29; RPL4; RPLP1; RPS17; RPL23A; RPL23; RPL19; RPL18A; EIF3K; RPS9; RPS5; RPL3
R-HSA-6785807 Interleukin-4 and Interleukin-13 signaling 3.03 3.00e-04 5.02e-03 12/38 PIM1; TIMP1; ANXA1; VIM; ITGB1; HIF1A; BATF; RORA; BCL2L1; JUNB; TGFB1; ITGB2
R-HSA-114608 Platelet degranulation 3.00 6.10e-05 1.23e-03 15/48 TTN; TUBA4A; TEX264; ANXA5; FAM3C; TIMP1; FLNA; FAM49B; SRGN; CD63; CALM1; ACTN4; TGFB1; SOD1
R-HSA-72695 Formation of the ternary complex, and subsequently, the 43S complex 3.00 6.10e-05 1.23e-03 15/48 RPS8; RPS7; RPS27A; RPS3A; RPS23; RPS18; RPS6; RPS13; RPS25; RPS24; RPS29; RPS17; EIF3K; RPS9; RPS5
R-HSA-418346 Platelet homeostasis 3.00 1.05e-03 1.53e-02 10/32 ATP2B4; ITPR1; ORAI2; PDE3B; PTPN6; ATP2B1; CALM1; PPP2R5C; PTGIR
R-HSA-909733 Interferon alpha/beta signaling 3.00 1.05e-03 1.53e-02 10/32 GBP2; HLA-A; HLA-E; HLA-C; HLA-B; PSMB8; PTPN6; ISG20; SAMHD1; IFNAR2
R-HSA-168643 Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways 3.00 1.05e-03 1.53e-02 10/32 TXNIP; RPS27A; CASP8; HSP90AB1; BIRC3; CASP1; NFKB2; PYCARD; CYLD; BCL2L1
R-HSA-76005 Response to elevated platelet cytosolic Ca2+ 2.95 4.29e-05 9.78e-04 16/52 TTN; TUBA4A; TEX264; ANXA5; FAM3C; TIMP1; FLNA; FAM49B; SRGN; CD63; CALM1; PRKCB; ACTN4; TGFB1; SOD1
R-HSA-397014 Muscle contraction 2.81 6.55e-04 1.00e-02 12/41 ATP2B4; TTN; ITPR1; ORAI2; ANXA1; VIM; ATP2B1; CALM1; ANXA2; MYL12A; TPM4
R-HSA-72649 Translation initiation complex formation 2.79 9.18e-05 1.77e-03 16/55 RPS8; RPS7; RPS27A; RPS3A; RPS23; RPS18; PABPC1; RPS6; RPS13; RPS25; RPS24; RPS29; RPS17; EIF3K; RPS9; RPS5
R-HSA-1500931 Cell-Cell communication 2.79 3.29e-03 3.99e-02 9/31 SPTBN1; CD47; FYB; FYN; FLNA; ITGB1; PTPN6; GRB2; ACTN4
R-HSA-168273 Influenza Viral RNA Transcription and Replication 2.78 7.01e-09 2.70e-07 35/121 RPS8; RPL5; RPS7; RPS27A; RPL37A; RPL32; RPL15; RPL9; GRSF1; RPS3A; RPS23; RPS18; RPL10A; RPL7; RPL30; POLR2K; RPS6; RPL12; RPL7A; RPL27A; RPS13; RPS25; RPS24; RPL6; RPS29; RPL4; RPLP1; RPS17; RPL23A; RPL23; RPL19; RPL18A; RPS9; RPS5; RPL3
R-HSA-72662 Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S 2.74 1.16e-04 2.19e-03 16/56 RPS8; RPS7; RPS27A; RPS3A; RPS23; RPS18; PABPC1; RPS6; RPS13; RPS25; RPS24; RPS29; RPS17; EIF3K; RPS9; RPS5
R-HSA-168255 Influenza Life Cycle 2.73 4.14e-09 1.84e-07 37/130 RPS8; RPL5; RPS7; RPS27A; RPL37A; RPL32; RPL15; RPL9; GRSF1; RPS3A; RPS23; RPS18; RPL10A; RPL7; RPL30; POLR2K; RPS6; CLTA; RPL12; RPL7A; RPL27A; RPS13; RPS25; RPS24; RPL6; RPS29; RPL4; RPLP1; RPS17; RPL23A; RPL23; RPL19; CALR; RPL18A; RPS9; RPS5; RPL3
R-HSA-372790 Signaling by GPCR 2.71 5.23e-09 2.21e-07 37/131 DHRS3; XCL2; XCL1; RGS1; CD55; RAMP1; ITPR1; PTGER4; CAMK4; REEP5; HRH2; GRK6; GPSM3; CXCR3; RDH10; ANXA1; RGS3; PDE3B; RASGRP2; NMT2; PMCH; LPAR6; GPR183; PTGER2; CALM1; GPR68; PRKCB; ARRB2; CCL1; CCL5; CCR7; GRB2; RGS19; S1PR4; PTGIR; TIAM1
R-HSA-388396 GPCR downstream signalling 2.68 1.22e-08 4.14e-07 36/129 DHRS3; XCL2; XCL1; RGS1; RAMP1; ITPR1; PTGER4; CAMK4; REEP5; HRH2; GRK6; GPSM3; CXCR3; RDH10; ANXA1; RGS3; PDE3B; RASGRP2; NMT2; PMCH; LPAR6; GPR183; PTGER2; CALM1; GPR68; PRKCB; ARRB2; CCL1; CCL5; CCR7; GRB2; RGS19; S1PR4; PTGIR; TIAM1
R-HSA-168254 Influenza Infection 2.62 8.73e-09 3.22e-07 38/139 RPS8; RPL5; RPS7; RPS27A; RPL37A; RPL32; RPL15; RPL9; GRSF1; RPS3A; RPS23; RPS18; RPL10A; RPL7; RPL30; POLR2K; RPS6; CLTA; RPL12; RPL7A; RPL27A; RPS13; RPS25; RPS24; RPL6; RPS29; RPL4; RPLP1; RPS17; RPL23A; RPL23; RPL19; CALR; RPL18A; TGFB1; RPS9; RPS5; RPL3
R-HSA-72702 Ribosomal scanning and start codon recognition 2.62 3.34e-04 5.49e-03 15/55 RPS8; RPS7; RPS27A; RPS3A; RPS23; RPS18; RPS6; RPS13; RPS25; RPS24; RPS29; RPS17; EIF3K; RPS9; RPS5
R-HSA-418594 G alpha (i) signalling events 2.54 1.31e-04 2.37e-03 18/68 DHRS3; RGS1; ITPR1; CAMK4; GPSM3; CXCR3; RDH10; ANXA1; NMT2; PMCH; GPR183; CALM1; CCL1; CCL5; CCR7; RGS19; S1PR4
R-HSA-388841 Costimulation by the CD28 family 2.51 2.94e-03 3.67e-02 11/42 LCK; HLA-DRA; HLA-DQA1; FYN; CD3G; MAP3K8; PTPN6; PPP2R5C; GRB2; GRAP2; PRR5
R-HSA-877300 Interferon gamma signaling 2.50 1.99e-03 2.60e-02 12/46 GBP2; GBP5; HLA-A; HLA-E; HLA-C; HLA-B; HLA-DRA; HLA-DQA1; PTPN6; IFNG; B2M; MT2A
R-HSA-76002 Platelet activation, signaling and aggregation 2.49 4.13e-06 1.11e-04 27/104 LCK; FCER1G; TTN; TUBA4A; ITPR1; TEX264; ANXA5; FYN; FAM3C; TIMP1; FLNA; YWHAZ; FAM49B; RASGRP2; APBB1IP; SRGN; PTPN6; CD63; CALM1; PRKCB; LAT; ARRB2; GRB2; ACTN4; TGFB1; SOD1
R-HSA-109582 Hemostasis 2.42 1.34e-10 1.08e-08 54/214 CAPZB; LCK; CD2; S100A10; FCER1G; SELL; ATP2B4; H3F3A; GYPC; TTN; ITGA4; TUBA4A; INPP5D; ITPR1; TEX264; CD47; ANXA5; SERPINB6; FYN; MYB; ORAI2; FAM3C; CD99; TIMP1; FLNA; DOK2; YWHAZ; FAM49B; PDE3B; RASGRP2; APBB1IP; ITGB1; SRGN; PTPN6; CD63; ATP2B1; SELPLG; CALM1; PPP2R5C; ANXA2; PRKCB; LAT; SPN; ITGAL; ARRB2; GRB2; H3F3B; KIF3B; ACTN4; TGFB1; PTGIR; SOD1; ITGB2
R-HSA-9010553 Regulation of expression of SLITs and ROBOs 2.35 4.64e-07 1.42e-05 36/147 RPS8; RPL5; RPS7; RPS27A; RPL37A; RPL32; RPL15; RPL9; RPS3A; RPS23; PSMB8; RPS18; RPL10A; RPL7; RPL30; PABPC1; RPS6; RPL12; RPL7A; RPL27A; RPS13; RPS25; RPS24; RPL6; PSME1; RPS29; RPL4; RPLP1; RPS17; RPL23A; RPL23; RPL19; RPL18A; RPS9; RPS5; RPL3
R-HSA-376176 Signaling by ROBO receptors 2.07 1.15e-05 2.91e-04 36/167 RPS8; RPL5; RPS7; RPS27A; RPL37A; RPL32; RPL15; RPL9; RPS3A; RPS23; PSMB8; RPS18; RPL10A; RPL7; RPL30; PABPC1; RPS6; RPL12; RPL7A; RPL27A; RPS13; RPS25; RPS24; RPL6; PSME1; RPS29; RPL4; RPLP1; RPS17; RPL23A; RPL23; RPL19; RPL18A; RPS9; RPS5; RPL3
R-HSA-6791226 Major pathway of rRNA processing in the nucleolus and cytosol 2.07 2.12e-05 5.22e-04 34/158 RPS8; RPL5; RPS7; RPS27A; RPL37A; RPL32; RPL15; RPL9; RPS3A; RPS23; RPS18; RPL10A; ERI1; RPL7; RPL30; RPS6; RPL12; RPL7A; RPL27A; RPS13; RPS25; RPS24; RPL6; RPS29; RPL4; RPLP1; RPS17; RPL23A; RPL23; RPL19; RPL18A; RPS9; RPS5; RPL3
R-HSA-422475 Axon guidance 2.05 5.74e-08 1.88e-06 55/257 RPS8; RPL5; PTPRC; RPS7; SPTBN1; RPS27A; RPL37A; TUBA4A; RPL32; RPL15; SIAH2; RPL9; RPS3A; RPS23; PSMB8; RPS18; RPL10A; HSP90AB1; FYN; MSN; DOK2; FGFR1; SDCBP; RPL7; RPL30; PABPC1; RPS6; CLTA; RPL12; RPL7A; RPL27A; RPS13; RDX; RPS25; ITGB1; ANK3; RPS24; ABLIM1; RPL6; PSME1; RPS29; RPL4; RPLP1; RPS17; RPL23A; RPL23; RPL19; GRB2; MYL12A; RPL18A; RPS9; RPS5; RPL3; TIAM1; COL6A2
R-HSA-449147 Signaling by Interleukins 2.03 1.06e-06 3.12e-05 46/217 LCK; PTPN7; RPS27A; PTPN4; PTPN18; INPP5D; CISH; IL7R; CSF2; SKP1; PSMB8; PIM1; FYN; TIMP1; MSN; DUSP4; YWHAZ; ANXA1; CASP1; IL10RA; IL2RA; VIM; MAP3K8; ITGB1; HNRNPF; NFKB2; PTPN6; IFNG; PSME1; NFKBIA; HIF1A; BATF; ANXA2; RORA; IL21R; MAP2K3; LGALS9; CCL5; GRB2; P4HB; BCL2L1; CNN2; JUNB; TGFB1; SOD1; ITGB2
RASA2 : 42 significant Reactome pathways
GeneSet description enrichRatio pValue FDR GeneRatio geneSymbols
R-HSA-202430 Translocation of ZAP-70 to Immunological synapse 18.00 3.05e-08 5.40e-06 7/14 HLA-DRA; HLA-DRB5; HLA-DRB1; HLA-DQA1; HLA-DQB1; HLA-DPA1; HLA-DPB1
R-HSA-389948 PD-1 signaling 16.80 5.58e-08 8.24e-06 7/15 HLA-DRA; HLA-DRB5; HLA-DRB1; HLA-DQA1; HLA-DQB1; HLA-DPA1; HLA-DPB1
R-HSA-202427 Phosphorylation of CD3 and TCR zeta chains 15.80 9.70e-08 1.23e-05 7/16 HLA-DRA; HLA-DRB5; HLA-DRB1; HLA-DQA1; HLA-DQB1; HLA-DPA1; HLA-DPB1
R-HSA-375276 Peptide ligand-binding receptors 14.40 1.62e-06 1.15e-04 6/15 XCL2; XCL1; CXCR4; CXCL10; CXCR3; CCR7
R-HSA-983170 Antigen Presentation: Folding, assembly and peptide loading of class I MHC 13.30 3.99e-07 3.21e-05 7/19 HLA-F; HLA-A; HLA-E; HLA-C; HLA-B; TAP1; B2M
R-HSA-446353 Cell-extracellular matrix interactions 13.10 1.59e-04 5.43e-03 4/11 ITGB1; ACTN1; ACTG1; VASP
R-HSA-216083 Integrin cell surface interactions 12.90 2.46e-05 1.21e-03 5/14 ITGA1; ITGB1; ITGB7; PECAM1; COL6A2
R-HSA-877300 Interferon gamma signaling 12.50 1.94e-14 1.72e-11 16/46 GBP5; STAT1; IRF1; HLA-F; HLA-A; HLA-E; HLA-C; HLA-B; HLA-DRA; HLA-DRB5; HLA-DRB1; HLA-DQA1; HLA-DQB1; HLA-DPA1; HLA-DPB1; B2M
R-HSA-202433 Generation of second messenger molecules 12.00 1.38e-07 1.26e-05 8/24 HLA-DRA; HLA-DRB5; HLA-DRB1; HLA-DQA1; HLA-DQB1; HLA-DPA1; HLA-DPB1; VASP
R-HSA-5607763 CLEC7A (Dectin-1) induces NFAT activation 10.80 2.17e-03 4.68e-02 3/10 ITPR1; CALM1
R-HSA-198933 Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell 10.40 2.87e-09 6.36e-07 11/38 SELL; CD8A; CD96; HLA-F; HLA-A; HLA-E; HLA-C; HLA-B; ITGB1; ITGB7; B2M
R-HSA-446728 Cell junction organization 10.30 4.53e-04 1.34e-02 4/14 ITGB1; ACTN1; ACTG1; VASP
R-HSA-1489509 DAG and IP3 signaling 10.30 4.53e-04 1.34e-02 4/14 ITPR1; PRKAR1B; CALM1
R-HSA-418360 Platelet calcium homeostasis 10.30 4.53e-04 1.34e-02 4/14 ITPR1; ATP2B1; CALM1
R-HSA-909733 Interferon alpha/beta signaling 10.10 1.14e-07 1.26e-05 9/32 STAT1; IRF1; HLA-F; HLA-A; HLA-E; HLA-C; HLA-B; IFITM2; ISG20
R-HSA-373076 Class A/1 (Rhodopsin-like receptors) 9.34 5.85e-06 3.24e-04 7/27 XCL2; XCL1; CXCR4; CXCL10; PTGER4; CXCR3; CCR7
R-HSA-5626467 RHO GTPases activate IQGAPs 9.00 7.89e-04 2.12e-02 4/16 TUBA4A; CALM1; ACTG1
R-HSA-112040 G-protein mediated events 8.48 1.01e-03 2.49e-02 4/17 ITPR1; PRKAR1B; CALM1
R-HSA-112043 PLC beta mediated events 8.48 1.01e-03 2.49e-02 4/17 ITPR1; PRKAR1B; CALM1
R-HSA-5578775 Ion homeostasis 8.00 1.27e-03 3.04e-02 4/18 ITPR1; ATP2B1; CALM1
R-HSA-983695 Antigen activates B Cell Receptor (BCR) leading to generation of second messengers 6.86 2.33e-03 4.92e-02 4/21 ITPR1; CALM1; CD79A
R-HSA-500792 GPCR ligand binding 6.81 5.39e-05 2.28e-03 7/37 XCL2; XCL1; CXCR4; CXCL10; PTGER4; CXCR3; CCR7
R-HSA-913531 Interferon Signaling 6.06 3.39e-10 1.00e-07 18/107 GBP5; STAT1; IRF1; HLA-F; HLA-A; HLA-E; HLA-C; HLA-B; HLA-DRA; HLA-DRB5; HLA-DRB1; HLA-DQA1; HLA-DQB1; HLA-DPA1; HLA-DPB1; IFITM2; B2M; ISG20
R-HSA-388841 Costimulation by the CD28 family 6.00 1.26e-04 4.65e-03 7/42 HLA-DRA; HLA-DRB5; HLA-DRB1; HLA-DQA1; HLA-DQB1; HLA-DPA1; HLA-DPB1
R-HSA-418594 G alpha (i) signalling events 5.83 1.82e-06 1.15e-04 11/68 DHRS3; RGS1; CXCR4; ITPR1; CXCL10; PRKAR1B; CXCR3; RGS10; CALM1; CCR7
R-HSA-1500931 Cell-Cell communication 5.81 1.43e-03 3.34e-02 5/31 ITGB1; ACTN1; ACTG1; SIRPG; VASP
R-HSA-1474244 Extracellular matrix organization 5.69 5.32e-04 1.47e-02 6/38 ITGA1; ITGB1; ITGB7; ACTN1; PECAM1; COL6A2
R-HSA-418346 Platelet homeostasis 5.63 1.66e-03 3.68e-02 5/32 ITPR1; ATP2B1; CALM1; PECAM1
R-HSA-114608 Platelet degranulation 5.25 3.00e-04 9.85e-03 7/48 TUBA4A; CTSW; CD63; ACTN1; CALM1; PECAM1
R-HSA-202733 Cell surface interactions at the vascular wall 5.15 9.24e-04 2.41e-02 6/42 SELL; CD74; DOK2; ITGB1; PECAM1; SIRPG
R-HSA-2132295 MHC class II antigen presentation 5.00 2.25e-05 1.17e-03 10/72 TUBA4A; CD74; HLA-DRA; HLA-DRB5; HLA-DRB1; HLA-DQA1; HLA-DQB1; HLA-DMB; HLA-DPA1; HLA-DPB1
R-HSA-76005 Response to elevated platelet cytosolic Ca2+ 4.85 4.98e-04 1.42e-02 7/52 TUBA4A; CTSW; CD63; ACTN1; CALM1; PECAM1
R-HSA-1236974 ER-Phagosome pathway 4.77 8.74e-05 3.37e-03 9/68 HLA-F; HLA-A; HLA-E; HLA-C; HLA-B; PSMB9; TAP1; PSME1; B2M
R-HSA-202424 Downstream TCR signaling 4.56 5.15e-05 2.28e-03 10/79 HLA-DRA; HLA-DRB5; HLA-DRB1; HLA-DQA1; HLA-DQB1; PSMB9; HLA-DPA1; HLA-DPB1; PSME1; NFKBIA
R-HSA-1236975 Antigen processing-Cross presentation 4.50 1.38e-04 4.88e-03 9/72 HLA-F; HLA-A; HLA-E; HLA-C; HLA-B; PSMB9; TAP1; PSME1; B2M
R-HSA-388396 GPCR downstream signalling 4.19 1.79e-06 1.15e-04 15/129 DHRS3; RHOC; XCL2; XCL1; RGS1; CXCR4; ITPR1; CXCL10; PTGER4; PRKAR1B; CXCR3; RGS10; CALM1; CCR7
R-HSA-202403 TCR signaling 4.17 4.97e-05 2.28e-03 11/95 HLA-DRA; HLA-DRB5; HLA-DRB1; HLA-DQA1; HLA-DQB1; PSMB9; HLA-DPA1; HLA-DPB1; PSME1; NFKBIA; VASP
R-HSA-372790 Signaling by GPCR 4.12 2.18e-06 1.29e-04 15/131 DHRS3; RHOC; XCL2; XCL1; RGS1; CXCR4; ITPR1; CXCL10; PTGER4; PRKAR1B; CXCR3; RGS10; CALM1; CCR7
R-HSA-1280215 Cytokine Signaling in Immune system 3.54 5.63e-11 2.49e-08 32/326 GBP5; PTPN7; STAT1; CXCL10; IL7R; IRF1; HLA-F; HLA-A; HLA-E; HLA-C; HLA-B; HLA-DRA; HLA-DRB5; HLA-DRB1; HLA-DQA1; HLA-DQB1; PSMB9; HLA-DPA1; HLA-DPB1; FSCN1; DUSP4; IFITM2; BIRC3; ITGB1; PSME1; NFKBIA; HSP90AA1; B2M; IL16; ISG20; LGALS9; CD70
R-HSA-109582 Hemostasis 2.86 6.32e-05 2.54e-03 17/214 SELL; TUBA4A; ITPR1; ITGA1; IRF1; CD74; PRKAR1B; DOK2; CTSW; ITGB1; CD63; ATP2B1; ACTN1; CALM1; PECAM1; SIRPG
R-HSA-1280218 Adaptive Immune System 2.72 1.43e-07 1.26e-05 30/397 SELL; CD8A; TUBA4A; ITPR1; CD96; CD74; HLA-F; HLA-A; HLA-E; HLA-C; HLA-B; HLA-DRA; HLA-DRB5; HLA-DRB1; HLA-DQA1; HLA-DQB1; PSMB9; TAP1; HLA-DMB; HLA-DPA1; HLA-DPB1; ITGB1; ITGB7; PSME1; NFKBIA; CALM1; B2M; CD79A; VASP
R-HSA-422475 Axon guidance 2.24 1.66e-03 3.68e-02 16/257 RHOC; CXCR4; TUBA4A; ITGA1; PSMB9; DOK2; ITGB1; RPS26; RPL41; PSME1; HSP90AA1; RPS17; RPS15A; ACTG1; VASP; COL6A2
TCEB2 : 56 significant Reactome pathways
GeneSet description enrichRatio pValue FDR GeneRatio geneSymbols
R-HSA-389948 PD-1 signaling 10.30 2.45e-09 6.59e-08 10/15 LCK; HLA-DRA; HLA-DRB5; HLA-DRB1; HLA-DQA1; HLA-DPA1; HLA-DPB1; CD3D; CD3G; PTPN6
R-HSA-156902 Peptide chain elongation 9.99 0.00e+00 0.00e+00 55/85 RPL11; RPS8; RPL5; RPS27; RPS7; RPS27A; RPL31; RPL32; RPL15; RPSA; RPL29; RPL34; RPS3A; RPL37; RPS14; RPS18; RPL10A; RPS12; RPS4X; RPL39; RPL7; RPL30; RPS6; RPL35; RPL12; RPL7A; RPL27A; RPS13; RPS3; RPS25; RPS24; RPL41; RPL6; RPLP0; RPL21; RPS29; RPL4; RPLP1; RPS17; RPS2; RPL13; RPL26; RPL23; RPL19; RPL38; RPS15; RPS28; RPL18A; RPS16; RPL18; RPL13A; RPS9; RPL28; RPS5; RPL3
R-HSA-192823 Viral mRNA Translation 9.99 0.00e+00 0.00e+00 55/85 RPL11; RPS8; RPL5; RPS27; RPS7; RPS27A; RPL31; RPL32; RPL15; RPSA; RPL29; RPL34; RPS3A; RPL37; RPS14; RPS18; RPL10A; RPS12; RPS4X; RPL39; RPL7; RPL30; RPS6; RPL35; RPL12; RPL7A; RPL27A; RPS13; RPS3; RPS25; RPS24; RPL41; RPL6; RPLP0; RPL21; RPS29; RPL4; RPLP1; RPS17; RPS2; RPL13; RPL26; RPL23; RPL19; RPL38; RPS15; RPS28; RPL18A; RPS16; RPL18; RPL13A; RPS9; RPL28; RPS5; RPL3
R-HSA-2408557 Selenocysteine synthesis 9.99 0.00e+00 0.00e+00 55/85 RPL11; RPS8; RPL5; RPS27; RPS7; RPS27A; RPL31; RPL32; RPL15; RPSA; RPL29; RPL34; RPS3A; RPL37; RPS14; RPS18; RPL10A; RPS12; RPS4X; RPL39; RPL7; RPL30; RPS6; RPL35; RPL12; RPL7A; RPL27A; RPS13; RPS3; RPS25; RPS24; RPL41; RPL6; RPLP0; RPL21; RPS29; RPL4; RPLP1; RPS17; RPS2; RPL13; RPL26; RPL23; RPL19; RPL38; RPS15; RPS28; RPL18A; RPS16; RPL18; RPL13A; RPS9; RPL28; RPS5; RPL3
R-HSA-156842 Eukaryotic Translation Elongation 9.94 0.00e+00 0.00e+00 56/87 RPL11; RPS8; RPL5; RPS27; RPS7; RPS27A; RPL31; EEF1B2; RPL32; RPL15; RPSA; RPL29; RPL34; RPS3A; RPL37; RPS14; RPS18; RPL10A; RPS12; RPS4X; RPL39; RPL7; RPL30; RPS6; RPL35; RPL12; RPL7A; RPL27A; RPS13; RPS3; RPS25; RPS24; RPL41; RPL6; RPLP0; RPL21; RPS29; RPL4; RPLP1; RPS17; RPS2; RPL13; RPL26; RPL23; RPL19; RPL38; RPS15; RPS28; RPL18A; RPS16; RPL18; RPL13A; RPS9; RPL28; RPS5; RPL3
R-HSA-202430 Translocation of ZAP-70 to Immunological synapse 9.92 2.62e-08 6.63e-07 9/14 LCK; HLA-DRA; HLA-DRB5; HLA-DRB1; HLA-DQA1; HLA-DPA1; HLA-DPB1; CD3D; CD3G
R-HSA-202427 Phosphorylation of CD3 and TCR zeta chains 9.65 6.17e-09 1.61e-07 10/16 LCK; PTPRC; HLA-DRA; HLA-DRB5; HLA-DRB1; HLA-DQA1; HLA-DPA1; HLA-DPB1; CD3D; CD3G
R-HSA-72764 Eukaryotic Translation Termination 9.65 0.00e+00 0.00e+00 55/88 RPL11; RPS8; RPL5; RPS27; RPS7; RPS27A; RPL31; RPL32; RPL15; RPSA; RPL29; RPL34; RPS3A; RPL37; RPS14; RPS18; RPL10A; RPS12; RPS4X; RPL39; RPL7; RPL30; RPS6; RPL35; RPL12; RPL7A; RPL27A; RPS13; RPS3; RPS25; RPS24; RPL41; RPL6; RPLP0; RPL21; RPS29; RPL4; RPLP1; RPS17; RPS2; RPL13; RPL26; RPL23; RPL19; RPL38; RPS15; RPS28; RPL18A; RPS16; RPL18; RPL13A; RPS9; RPL28; RPS5; RPL3
R-HSA-975956 Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) 9.54 0.00e+00 0.00e+00 55/89 RPL11; RPS8; RPL5; RPS27; RPS7; RPS27A; RPL31; RPL32; RPL15; RPSA; RPL29; RPL34; RPS3A; RPL37; RPS14; RPS18; RPL10A; RPS12; RPS4X; RPL39; RPL7; RPL30; RPS6; RPL35; RPL12; RPL7A; RPL27A; RPS13; RPS3; RPS25; RPS24; RPL41; RPL6; RPLP0; RPL21; RPS29; RPL4; RPLP1; RPS17; RPS2; RPL13; RPL26; RPL23; RPL19; RPL38; RPS15; RPS28; RPL18A; RPS16; RPL18; RPL13A; RPS9; RPL28; RPS5; RPL3
R-HSA-72689 Formation of a pool of free 40S subunits 8.84 0.00e+00 0.00e+00 55/96 RPL11; RPS8; RPL5; RPS27; RPS7; RPS27A; RPL31; RPL32; RPL15; RPSA; RPL29; RPL34; RPS3A; RPL37; RPS14; RPS18; RPL10A; RPS12; RPS4X; RPL39; RPL7; RPL30; RPS6; RPL35; RPL12; RPL7A; RPL27A; RPS13; RPS3; RPS25; RPS24; RPL41; RPL6; RPLP0; RPL21; RPS29; RPL4; RPLP1; RPS17; RPS2; RPL13; RPL26; RPL23; RPL19; RPL38; RPS15; RPS28; RPL18A; RPS16; RPL18; RPL13A; RPS9; RPL28; RPS5; RPL3
R-HSA-2408522 Selenoamino acid metabolism 8.73 0.00e+00 0.00e+00 56/99 RPL11; RPS8; RPL5; RPS27; RPS7; RPS27A; RPL31; DARS; RPL32; RPL15; RPSA; RPL29; RPL34; RPS3A; RPL37; RPS14; RPS18; RPL10A; RPS12; RPS4X; RPL39; RPL7; RPL30; RPS6; RPL35; RPL12; RPL7A; RPL27A; RPS13; RPS3; RPS25; RPS24; RPL41; RPL6; RPLP0; RPL21; RPS29; RPL4; RPLP1; RPS17; RPS2; RPL13; RPL26; RPL23; RPL19; RPL38; RPS15; RPS28; RPL18A; RPS16; RPL18; RPL13A; RPS9; RPL28; RPS5; RPL3
R-HSA-1799339 SRP-dependent cotranslational protein targeting to membrane 8.22 0.00e+00 0.00e+00 57/107 RPL11; RPS8; RPL5; RPS27; RPS7; RPS27A; RPL31; RPL32; RPL15; RPSA; RPL29; RPL34; RPS3A; RPL37; RPS14; RPS18; RPL10A; RPS12; SEC61G; RPS4X; RPL39; RPL7; RPL30; RPS6; RPL35; RPL12; RPL7A; RPL27A; RPS13; RPS3; RPS25; RPS24; RPL41; RPL6; RPLP0; RPL21; RPS29; RPL4; RPLP1; RPS17; RPS2; RPL13; RPL26; RPL23; RPL19; RPL38; SEC11C; RPS15; RPS28; RPL18A; RPS16; RPL18; RPL13A; RPS9; RPL28; RPS5; RPL3
R-HSA-70263 Gluconeogenesis 8.17 2.67e-07 6.58e-06 9/17 ENO1; PGK1; PGAM1; GAPDH; TPI1; ENO2; ALDOA; ALDOC; GPI
R-HSA-156827 L13a-mediated translational silencing of Ceruloplasmin expression 8.01 0.00e+00 0.00e+00 55/106 RPL11; RPS8; RPL5; RPS27; RPS7; RPS27A; RPL31; RPL32; RPL15; RPSA; RPL29; RPL34; RPS3A; RPL37; RPS14; RPS18; RPL10A; RPS12; RPS4X; RPL39; RPL7; RPL30; RPS6; RPL35; RPL12; RPL7A; RPL27A; RPS13; RPS3; RPS25; RPS24; RPL41; RPL6; RPLP0; RPL21; RPS29; RPL4; RPLP1; RPS17; RPS2; RPL13; RPL26; RPL23; RPL19; RPL38; RPS15; RPS28; RPL18A; RPS16; RPL18; RPL13A; RPS9; RPL28; RPS5; RPL3
R-HSA-927802 Nonsense-Mediated Decay (NMD) 8.01 0.00e+00 0.00e+00 55/106 RPL11; RPS8; RPL5; RPS27; RPS7; RPS27A; RPL31; RPL32; RPL15; RPSA; RPL29; RPL34; RPS3A; RPL37; RPS14; RPS18; RPL10A; RPS12; RPS4X; RPL39; RPL7; RPL30; RPS6; RPL35; RPL12; RPL7A; RPL27A; RPS13; RPS3; RPS25; RPS24; RPL41; RPL6; RPLP0; RPL21; RPS29; RPL4; RPLP1; RPS17; RPS2; RPL13; RPL26; RPL23; RPL19; RPL38; RPS15; RPS28; RPL18A; RPS16; RPL18; RPL13A; RPS9; RPL28; RPS5; RPL3
R-HSA-975957 Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) 8.01 0.00e+00 0.00e+00 55/106 RPL11; RPS8; RPL5; RPS27; RPS7; RPS27A; RPL31; RPL32; RPL15; RPSA; RPL29; RPL34; RPS3A; RPL37; RPS14; RPS18; RPL10A; RPS12; RPS4X; RPL39; RPL7; RPL30; RPS6; RPL35; RPL12; RPL7A; RPL27A; RPS13; RPS3; RPS25; RPS24; RPL41; RPL6; RPLP0; RPL21; RPS29; RPL4; RPLP1; RPS17; RPS2; RPL13; RPL26; RPL23; RPL19; RPL38; RPS15; RPS28; RPL18A; RPS16; RPL18; RPL13A; RPS9; RPL28; RPS5; RPL3
R-HSA-72706 GTP hydrolysis and joining of the 60S ribosomal subunit 7.93 0.00e+00 0.00e+00 55/107 RPL11; RPS8; RPL5; RPS27; RPS7; RPS27A; RPL31; RPL32; RPL15; RPSA; RPL29; RPL34; RPS3A; RPL37; RPS14; RPS18; RPL10A; RPS12; RPS4X; RPL39; RPL7; RPL30; RPS6; RPL35; RPL12; RPL7A; RPL27A; RPS13; RPS3; RPS25; RPS24; RPL41; RPL6; RPLP0; RPL21; RPS29; RPL4; RPLP1; RPS17; RPS2; RPL13; RPL26; RPL23; RPL19; RPL38; RPS15; RPS28; RPL18A; RPS16; RPL18; RPL13A; RPS9; RPL28; RPS5; RPL3
R-HSA-72613 Eukaryotic Translation Initiation 7.45 0.00e+00 0.00e+00 55/114 RPL11; RPS8; RPL5; RPS27; RPS7; RPS27A; RPL31; RPL32; RPL15; RPSA; RPL29; RPL34; RPS3A; RPL37; RPS14; RPS18; RPL10A; RPS12; RPS4X; RPL39; RPL7; RPL30; RPS6; RPL35; RPL12; RPL7A; RPL27A; RPS13; RPS3; RPS25; RPS24; RPL41; RPL6; RPLP0; RPL21; RPS29; RPL4; RPLP1; RPS17; RPS2; RPL13; RPL26; RPL23; RPL19; RPL38; RPS15; RPS28; RPL18A; RPS16; RPL18; RPL13A; RPS9; RPL28; RPS5; RPL3
R-HSA-72737 Cap-dependent Translation Initiation 7.45 0.00e+00 0.00e+00 55/114 RPL11; RPS8; RPL5; RPS27; RPS7; RPS27A; RPL31; RPL32; RPL15; RPSA; RPL29; RPL34; RPS3A; RPL37; RPS14; RPS18; RPL10A; RPS12; RPS4X; RPL39; RPL7; RPL30; RPS6; RPL35; RPL12; RPL7A; RPL27A; RPS13; RPS3; RPS25; RPS24; RPL41; RPL6; RPLP0; RPL21; RPS29; RPL4; RPLP1; RPS17; RPS2; RPL13; RPL26; RPL23; RPL19; RPL38; RPS15; RPS28; RPL18A; RPS16; RPL18; RPL13A; RPS9; RPL28; RPS5; RPL3
R-HSA-72695 Formation of the ternary complex, and subsequently, the 43S complex 7.40 1.22e-15 3.73e-14 23/48 RPS8; RPS27; RPS7; RPS27A; RPSA; RPS3A; RPS14; RPS18; RPS12; RPS4X; RPS6; RPS13; RPS3; RPS25; RPS24; RPS29; RPS17; RPS2; RPS15; RPS28; RPS16; RPS9; RPS5
R-HSA-168273 Influenza Viral RNA Transcription and Replication 7.14 0.00e+00 0.00e+00 56/121 RPL11; RPS8; RPL5; RPS27; RPS7; RPS27A; RPL31; RPL32; RPL15; RPSA; RPL29; POLR2H; RPL34; RPS3A; RPL37; RPS14; RPS18; RPL10A; RPS12; RPS4X; RPL39; RPL7; RPL30; RPS6; RPL35; RPL12; RPL7A; RPL27A; RPS13; RPS3; RPS25; RPS24; RPL41; RPL6; RPLP0; RPL21; RPS29; RPL4; RPLP1; RPS17; RPS2; RPL13; RPL26; RPL23; RPL19; RPL38; RPS15; RPS28; RPL18A; RPS16; RPL18; RPL13A; RPS9; RPL28; RPS5; RPL3
R-HSA-168255 Influenza Life Cycle 6.65 0.00e+00 0.00e+00 56/130 RPL11; RPS8; RPL5; RPS27; RPS7; RPS27A; RPL31; RPL32; RPL15; RPSA; RPL29; POLR2H; RPL34; RPS3A; RPL37; RPS14; RPS18; RPL10A; RPS12; RPS4X; RPL39; RPL7; RPL30; RPS6; RPL35; RPL12; RPL7A; RPL27A; RPS13; RPS3; RPS25; RPS24; RPL41; RPL6; RPLP0; RPL21; RPS29; RPL4; RPLP1; RPS17; RPS2; RPL13; RPL26; RPL23; RPL19; RPL38; RPS15; RPS28; RPL18A; RPS16; RPL18; RPL13A; RPS9; RPL28; RPS5; RPL3
R-HSA-72649 Translation initiation complex formation 6.46 4.88e-14 1.40e-12 23/55 RPS8; RPS27; RPS7; RPS27A; RPSA; RPS3A; RPS14; RPS18; RPS12; RPS4X; RPS6; RPS13; RPS3; RPS25; RPS24; RPS29; RPS17; RPS2; RPS15; RPS28; RPS16; RPS9; RPS5
R-HSA-72702 Ribosomal scanning and start codon recognition 6.46 4.88e-14 1.40e-12 23/55 RPS8; RPS27; RPS7; RPS27A; RPSA; RPS3A; RPS14; RPS18; RPS12; RPS4X; RPS6; RPS13; RPS3; RPS25; RPS24; RPS29; RPS17; RPS2; RPS15; RPS28; RPS16; RPS9; RPS5
R-HSA-202433 Generation of second messenger molecules 6.43 9.49e-07 2.27e-05 10/24 LCK; LCP2; HLA-DRA; HLA-DRB5; HLA-DRB1; HLA-DQA1; HLA-DPA1; HLA-DPB1; CD3D; CD3G
R-HSA-72662 Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S 6.34 7.82e-14 2.16e-12 23/56 RPS8; RPS27; RPS7; RPS27A; RPSA; RPS3A; RPS14; RPS18; RPS12; RPS4X; RPS6; RPS13; RPS3; RPS25; RPS24; RPS29; RPS17; RPS2; RPS15; RPS28; RPS16; RPS9; RPS5
R-HSA-168254 Influenza Infection 6.22 0.00e+00 0.00e+00 56/139 RPL11; RPS8; RPL5; RPS27; RPS7; RPS27A; RPL31; RPL32; RPL15; RPSA; RPL29; POLR2H; RPL34; RPS3A; RPL37; RPS14; RPS18; RPL10A; RPS12; RPS4X; RPL39; RPL7; RPL30; RPS6; RPL35; RPL12; RPL7A; RPL27A; RPS13; RPS3; RPS25; RPS24; RPL41; RPL6; RPLP0; RPL21; RPS29; RPL4; RPLP1; RPS17; RPS2; RPL13; RPL26; RPL23; RPL19; RPL38; RPS15; RPS28; RPL18A; RPS16; RPL18; RPL13A; RPS9; RPL28; RPS5; RPL3
R-HSA-844456 The NLRP3 inflammasome 6.17 2.64e-03 4.18e-02 4/10 TXNIP; HSP90AB1; TXN; PYCARD
R-HSA-5669034 TNFs bind their physiological receptors 6.17 2.64e-03 4.18e-02 4/10 TNFRSF18; TNFRSF4; CD27; CD70
R-HSA-9010553 Regulation of expression of SLITs and ROBOs 6.09 0.00e+00 0.00e+00 58/147 RPL11; RPS8; RPL5; RPS27; RPS7; RPS27A; RPL31; RPL32; RPL15; RPSA; RPL29; RPL34; RPS3A; RPL37; RPS14; PSMB8; PSMB9; RPS18; RPL10A; RPS12; RPS4X; RPL39; RPL7; RPL30; RPS6; RPL35; RPL12; RPL7A; RPL27A; RPS13; RPS3; RPS25; RPS24; RPL41; RPL6; RPLP0; RPL21; RPS29; RPL4; RPLP1; RPS17; RPS2; TCEB2; RPL13; RPL26; RPL23; RPL19; RPL38; RPS15; RPS28; RPL18A; RPS16; RPL18; RPL13A; RPS9; RPL28; RPS5; RPL3
R-HSA-376176 Signaling by ROBO receptors 5.45 0.00e+00 0.00e+00 59/167 RPL11; RPS8; RPL5; RPS27; RPS7; RPS27A; RPL31; RPL32; RPL15; RPSA; RPL29; RPL34; RPS3A; RPL37; RPS14; PSMB8; PSMB9; RPS18; RPL10A; RPS12; RPS4X; RPL39; RPL7; RPL30; RPS6; RPL35; RPL12; RPL7A; RPL27A; RPS13; RPS3; RPS25; RPS24; RPL41; RPL6; RPLP0; RPL21; RPS29; RPL4; RPLP1; RPS17; RPS2; TCEB2; RPL13; PFN1; RPL26; RPL23; RPL19; RPL38; RPS15; RPS28; RPL18A; RPS16; RPL18; RPL13A; RPS9; RPL28; RPS5; RPL3
R-HSA-191273 Cholesterol biosynthesis 5.40 1.64e-04 3.73e-03 7/20 FDPS; HMGCS1; ACAT2; EBP; FDFT1; SQLE; DHCR7
R-HSA-6791226 Major pathway of rRNA processing in the nucleolus and cytosol 5.37 0.00e+00 0.00e+00 55/158 RPL11; RPS8; RPL5; RPS27; RPS7; RPS27A; RPL31; RPL32; RPL15; RPSA; RPL29; RPL34; RPS3A; RPL37; RPS14; RPS18; RPL10A; RPS12; RPS4X; RPL39; RPL7; RPL30; RPS6; RPL35; RPL12; RPL7A; RPL27A; RPS13; RPS3; RPS25; RPS24; RPL41; RPL6; RPLP0; RPL21; RPS29; RPL4; RPLP1; RPS17; RPS2; RPL13; RPL26; RPL23; RPL19; RPL38; RPS15; RPS28; RPL18A; RPS16; RPL18; RPL13A; RPS9; RPL28; RPS5; RPL3
R-HSA-8868773 rRNA processing in the nucleus and cytosol 5.05 0.00e+00 0.00e+00 55/168 RPL11; RPS8; RPL5; RPS27; RPS7; RPS27A; RPL31; RPL32; RPL15; RPSA; RPL29; RPL34; RPS3A; RPL37; RPS14; RPS18; RPL10A; RPS12; RPS4X; RPL39; RPL7; RPL30; RPS6; RPL35; RPL12; RPL7A; RPL27A; RPS13; RPS3; RPS25; RPS24; RPL41; RPL6; RPLP0; RPL21; RPS29; RPL4; RPLP1; RPS17; RPS2; RPL13; RPL26; RPL23; RPL19; RPL38; RPS15; RPS28; RPL18A; RPS16; RPL18; RPL13A; RPS9; RPL28; RPS5; RPL3
R-HSA-72312 rRNA processing 4.85 0.00e+00 0.00e+00 55/175 RPL11; RPS8; RPL5; RPS27; RPS7; RPS27A; RPL31; RPL32; RPL15; RPSA; RPL29; RPL34; RPS3A; RPL37; RPS14; RPS18; RPL10A; RPS12; RPS4X; RPL39; RPL7; RPL30; RPS6; RPL35; RPL12; RPL7A; RPL27A; RPS13; RPS3; RPS25; RPS24; RPL41; RPL6; RPLP0; RPL21; RPS29; RPL4; RPLP1; RPS17; RPS2; RPL13; RPL26; RPL23; RPL19; RPL38; RPS15; RPS28; RPL18A; RPS16; RPL18; RPL13A; RPS9; RPL28; RPS5; RPL3
R-HSA-71291 Metabolism of amino acids and derivatives 4.51 0.00e+00 0.00e+00 62/212 RPL11; RPS8; RPL5; RPS27; RPS7; RPS27A; RPL31; DARS; RPL32; RPL15; RPSA; RPL29; RPL34; RPS3A; RPL37; RPS14; PSMB8; PSMB9; RPS18; RPL10A; RPS12; RPS4X; RPL39; RPL7; RPL30; RPS6; RPL35; RPL12; RPL7A; RPL27A; RPS13; RPS3; RPS25; RPS24; BCAT1; RPL41; RPL6; RPLP0; RPL21; RPS29; SQRDL; RPL4; RPLP1; RPS17; RPS2; BCKDK; RPL13; RPL26; RPL23; RPL19; RPL38; RPS15; OAZ1; RPS28; RPL18A; RPS16; RPL18; RPL13A; RPS9; RPL28; RPS5; RPL3
R-HSA-70171 Glycolysis 4.25 2.90e-05 6.75e-04 11/40 ENO1; PGK1; PFKP; PGAM1; GAPDH; TPI1; ENO2; PKM; ALDOA; ALDOC; GPI
R-HSA-3299685 Detoxification of Reactive Oxygen Species 4.21 2.15e-03 3.59e-02 6/22 ATOX1; TXN; GSTP1; ERO1A; P4HB; SOD1
R-HSA-1655829 Regulation of cholesterol biosynthesis by SREBP (SREBF) 4.12 4.64e-04 9.34e-03 8/30 FDPS; INSIG2; HMGCS1; INSIG1; FDFT1; SQLE; DHCR7; SCD
R-HSA-373076 Class A/1 (Rhodopsin-like receptors) 4.00 1.27e-03 2.35e-02 7/27 UTS2; CXCR3; GPR183; GPR65; CCL1; CCL5; PTGIR
R-HSA-422475 Axon guidance 3.90 0.00e+00 0.00e+00 65/257 RPL11; RPS8; RPL5; RPS27; ARPC5; PTPRC; RPS7; RPS27A; RPL31; RPL32; RPL15; RPSA; RPL29; RPL34; RPS3A; RPL37; RPS14; PSMB8; PSMB9; RPS18; RPL10A; HSP90AB1; RPS12; ARPC1B; RPS4X; RPL39; RPL7; RPL30; RPS6; RPL35; RPL12; RPL7A; RPL27A; RPS13; CFL1; RPS3; RPS25; RPS24; RPL41; RPL6; RPLP0; RPL21; RPS29; RPL4; RPLP1; RPS17; RPS2; TCEB2; RPL13; PFN1; RPL26; RPL23; RPL19; RPL38; MYL12A; RPS15; RPS28; RPL18A; RPS16; RPL18; RPL13A; RPS9; RPL28; RPS5; RPL3
R-HSA-388841 Costimulation by the CD28 family 3.68 2.51e-04 5.18e-03 10/42 LCK; HLA-DRA; HLA-DRB5; HLA-DRB1; HLA-DQA1; HLA-DPA1; HLA-DPB1; CD3D; CD3G; PTPN6
R-HSA-202733 Cell surface interactions at the vascular wall 3.68 2.51e-04 5.18e-03 10/42 LCK; CD58; CD74; CD44; PTPN6; PECAM1; SLC16A3; SIRPG; MIF; ITGB2
R-HSA-72766 Translation 3.55 0.00e+00 0.00e+00 61/265 RPL11; RPS8; RPL5; RPS27; RPS7; RPS27A; RPL31; DARS; EEF1B2; RPL32; RPL15; RPSA; RPL29; RPL34; RPS3A; RPL37; RPS14; RPS18; RPL10A; MRPL14; RPS12; SEC61G; RPS4X; RPL39; RPL7; RPL30; RPS6; RPL35; RPL12; RPL7A; RPL27A; RPS13; RPS3; RPS25; RPS24; RPL41; RPL6; RPLP0; RPL21; RPS29; RPL4; RPLP1; RPS17; RPS2; RPL13; RPL26; RPL23; RPL19; RPL38; SEC11C; RPS15; RPS28; RPL18A; RPS16; RPL18; RPL13A; RPS9; RPL28; RPS5; RPL3; MRPS6
R-HSA-70326 Glucose metabolism 3.54 1.78e-04 3.94e-03 11/48 ENO1; PGK1; PFKP; PGAM1; GAPDH; TPI1; ENO2; PKM; ALDOA; ALDOC; GPI
R-HSA-198933 Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell 3.25 2.47e-03 4.05e-02 8/38 SLAMF7; CD8A; CD8B; CD96; NPDC1; CD3D; CD3G; ITGB2
R-HSA-5663205 Infectious disease 3.23 0.00e+00 0.00e+00 64/306 RPL11; LCK; RPS8; RPL5; RPS27; RPS7; RPS27A; CD8B; RPL31; RPL32; RPL15; RPSA; RPL29; POLR2H; RPL34; RPS3A; RPL37; SKP1; RPS14; PSMB8; PSMB9; RPS18; HMGA1; RPL10A; HSP90AB1; RPS12; RPS4X; RPL39; RPL7; RPL30; RPS6; RPL35; RPL12; RPL7A; RPL27A; RPS13; RPS3; RPS25; RPS24; RPL41; RPL6; RPLP0; RPL21; RPS29; RPL4; RPLP1; RPS17; RPS2; TCEB2; RPL13; RPL26; RPL23; RPL19; RPL38; RPS15; RPS28; RPL18A; RPS16; RPL18; RPL13A; RPS9; RPL28; RPS5; RPL3
R-HSA-114608 Platelet degranulation 3.22 7.91e-04 1.56e-02 10/48 TAGLN2; TIMP1; CFL1; CTSW; SRGN; ACTN1; ALDOA; PFN1; PECAM1; SOD1
R-HSA-76005 Response to elevated platelet cytosolic Ca2+ 2.97 1.52e-03 2.69e-02 10/52 TAGLN2; TIMP1; CFL1; CTSW; SRGN; ACTN1; ALDOA; PFN1; PECAM1; SOD1
R-HSA-1266738 Developmental Biology 2.97 0.00e+00 0.00e+00 68/354 RPL11; RPS8; JUN; RPL5; RPS27; ARPC5; PTPRC; RPS7; RPS27A; RPL31; RPL32; RPL15; RPSA; RPL29; POLR2H; RPL34; RPS3A; RPL37; RPS14; PSMB8; PSMB9; RPS18; RPL10A; HSP90AB1; RPS12; H2AFV; ARPC1B; RPS4X; RPL39; RPL7; RPL30; RPS6; RPL35; RPL12; RPL7A; RPL27A; RPS13; CFL1; RPS3; RPS25; RPS24; RPL41; RPL6; RPLP0; RPL21; RPS29; RPL4; RPLP1; RPS17; RPS2; TCEB2; RPL13; PFN1; RPL26; RPL23; RPL19; RPL38; MYL12A; RPS15; RPS28; RPL18A; RPS16; RPL18; RPL13A; RPS9; RPL28; RPS5; RPL3
R-HSA-8957322 Metabolism of steroids 2.76 2.72e-03 4.23e-02 10/56 FDPS; INSIG2; HMGCS1; ACAT2; INSIG1; EBP; FDFT1; SQLE; DHCR7; SCD
R-HSA-2132295 MHC class II antigen presentation 2.57 1.95e-03 3.33e-02 12/72 CAPZB; CD74; HLA-DRA; HLA-DRB5; HLA-DRB1; HLA-DQA1; HLA-DMB; HLA-DPA1; HLA-DPB1; LAG3; CTSH; KIF3B
R-HSA-202424 Downstream TCR signaling 2.54 1.44e-03 2.61e-02 13/79 LCK; RPS27A; SKP1; HLA-DRA; HLA-DRB5; HLA-DRB1; HLA-DQA1; PSMB8; PSMB9; HLA-DPA1; HLA-DPB1; CD3D; CD3G
R-HSA-202403 TCR signaling 2.44 9.83e-04 1.85e-02 15/95 LCK; PTPRC; RPS27A; SKP1; LCP2; HLA-DRA; HLA-DRB5; HLA-DRB1; HLA-DQA1; PSMB8; PSMB9; HLA-DPA1; HLA-DPB1; CD3D; CD3G
R-HSA-76002 Platelet activation, signaling and aggregation 2.37 8.96e-04 1.73e-02 16/104 LCK; RAP1A; TAGLN2; LCP2; TIMP1; CFL1; CTSW; SRGN; PTPN6; PRKCH; ACTN1; ALDOA; PFN1; PECAM1; GNA15; SOD1
R-HSA-109582 Hemostasis 2.02 2.09e-04 4.53e-03 28/214 CAPZB; LCK; RAP1A; CD58; S100A10; TAGLN2; CD74; LCP2; TIMP1; CD44; CFL1; CTSW; GATA3; SRGN; PTPN6; PRKCH; ACTN1; ALDOA; PFN1; PECAM1; SLC16A3; SIRPG; KIF3B; GNA15; PTGIR; MIF; SOD1; ITGB2
Summary:
Marker ARID1A CBLB CD3D CD5 LCP2 RASA2 TCEB2
Signif_GO_terms 43 54 14 12 62 42 56