1 Data Description

References: Perspective on Oncogenic Processes at the End of the Beginning of Cancer Genomics.

Data source:
FireBrowse TCGA BRCA Archives.

Samples:
TCGA breast invasive carcinoma (BRCA) tumor samples in file "illuminahiseq_rnaseq-gene_expression".
To avoid possible confounding due to gender and race, we confined our study samples to be only from female Caucasian subjects.
In addition, only samples with somatic mutation annotation were kept, resulted in 573 samples.

Genes:
Only the top 10k variable genes in samples of consideration were kept. (Variance was calculated based on the TMM-normalized log2(CPM) data.)

Normalization:
Raw counts normalized by TMM using edgeR, converted to log2(CPM), then corrected for subject age and tumor purity. The corrected and scaled expression data were used as input for subsequent factor analysis.

Perturbations:
Somatic mutation status of selected frequently mutated driver genes (TP53, CDH1, GATA3, MAP3K1, PIK3CA).
Mutations were classified into 2 types: missense mutations and loss of function (LOF) mutations.

2 GSFA results

Here, our "guide", \(G\) matrix, consists of the somatic mutation status (missense and LOF separated) of top 5 driver genes across samples.

We specified 20 factors in our model. In each case, Gibbs sampling was conducted for 3000 iterations, and the posterior mean estimates were averaged over the last 1000 iterations.

3 Factor ~ Perturbation Association

3.1 Perturbation effects on factors

Fisrt of all, we look at the estimated effects of gene perturbations on factors inferred by GSFA.

Factors from bulk data were originally very dense, so when imposed upon a normal-mixture prior, they all become really sparse:

Factor	Factor_1	Factor_2	Factor_3	Factor_4	Factor_5
Density	0.0000	0.0004	0.0386	0.0837	0.0514
Factor	Factor_6	Factor_7	Factor_8	Factor_9	Factor_10
Density	0.0087	0.1005	0.0378	0.0377	0.0480
Factor	Factor_11	Factor_12	Factor_13	Factor_14	Factor_15
Density	0.0148	0.0012	0.0304	0.0418	0.0309
Factor	Factor_16	Factor_17	Factor_18	Factor_19	Factor_20
Density	0.0656	0.0262	0.0185	0.0391	0.0422

We found that 5 somatic mutations, TP53_LOF, TP53_mis, CDH1_LOF, GATA3_LOF and PIK3CA_mis, has significant effects (PIP > 0.95) on at least 1 of the 20 inferred factors.

Effects of all targets on all factors:

Here is a closer look at the estimated effects of selected mutations on selected factors:

Enriched GO terms of selected factors:

4 (cell/tissue development), 5 (immune activation), 8 (neural development),
13 (cell cycle), 16 (immune response), 18 (immune response), 20 (vessel development).

3.2 Factor-perturbation association p values

We can also assess the correlations between each pair of perturbation and inferred factor.
The distribution of correlation p values show significant signals.

4 Factor Interpretation

4.1 Correlation within factors

Since the GSFA model does not enforce orthogonality among factors, we also need to inspect the pairwise correlation within them to see if there is any redundancy.

As we can see below, the inferred factors are correlated with each other to some extent, especially among factors 13-20.

4.2 Gene loading in factors

To understand these latent factors, we inspect within them the loadings (weights) of several marker genes for cell proliferation and T cell activation/resting states.

protein_name	gene_name	type
IL-7 receptor	IL7R	T cell resting state
C-C motif chemokine receptor 7	CCR7	T cell resting state
Granzyme B	GZMB	T cell activation
Interferon gamma	IFNG	T cell activation
CD44	CD44	T cell activation
IL-2 receptor	IL2RA	T cell activation
X-C motif chemokine ligand 1	XCL1	T cell activation
GITR	TNFRSF18	T cell activation
LFA-1	ITGAL	T cell activation
Marker of proliferation Ki-67	MKI67	Cell proliferation
DNA topoisomerase II alpha	TOP2A	Cell proliferation
Centromere protein F	CENPF	Cell proliferation

We visualize both the gene PIPs (dot size) and gene weights (dot color) in all factors:

A closer look at some factors that are associated with mutations:

4.3 GO enrichment analysis in factors

To further characterize these latent factors, we perform GO (gene ontology) enrichment analysis of genes loaded on the factors using WebGestalt.

Foreground genes: genes w/ non-zero loadings in each factor (gene PIP > 0.95);
Background genes: all 10k genes used in GSFA;
Statistical test: hypergeometric test (over-representation test);
Gene sets: GO Slim "Biological Process" (non-redundant).

GO terms that passed over-representation test fold change \(\geq\) 2 and q value \(<\) 0.05:

Factor 3 : 12 significant GO terms

GeneSet	description	enrichRatio	pValue	FDR	GeneRatio	geneSymbols
GO:0006399	tRNA metabolic process	10.20	2.19e-06	5.34e-04	7/17	ADAT3; CTU1; CTU2; DUS1L; PUSL1; QTRT1; TRMT61A
GO:0006414	translational elongation	10.20	2.19e-06	5.34e-04	7/17	AURKAIP1; EEF1D; GADD45GIP1; MRPL12; MRPL23; MRPL41; MRPS34
GO:0033108	mitochondrial respiratory chain complex assembly	9.56	1.01e-04	9.10e-03	5/13	UQCC3; NDUFB7; NDUFS6; NDUFS7; NDUFS8
GO:0140053	mitochondrial gene expression	9.32	2.30e-05	3.12e-03	6/16	AURKAIP1; GADD45GIP1; MRPL12; MRPL23; MRPL41; MRPS34
GO:0010257	NADH dehydrogenase complex assembly	9.04	6.78e-04	4.60e-02	4/11	NDUFB7; NDUFS6; NDUFS7; NDUFS8
GO:0009451	RNA modification	8.28	2.62e-06	5.34e-04	8/24	CTU1; CTU2; DUS1L; MRM1; PUSL1; QTRT1; RPUSD1; TRMT61A
GO:0034470	ncRNA processing	8.10	1.37e-10	1.12e-07	15/46	ADAT3; BOP1; FAM207A; CTU1; CTU2; DUS1L; EXOSC4; NOP53; MRM1; PUSL1; QTRT1; RPS15; RRP7A; SART1; TRMT61A
GO:0016072	rRNA metabolic process	6.41	2.20e-05	3.12e-03	8/31	BOP1; FAM207A; EXOSC4; NOP53; MRM1; RPS15; RRP7A; SART1
GO:0007006	mitochondrial membrane organization	5.61	1.82e-04	1.48e-02	7/31	ALKBH7; ATP5F1D; BBC3; UQCC3; HSPA1A; TIMM13; ZNF205
GO:0022613	ribonucleoprotein complex biogenesis	4.78	3.37e-05	3.92e-03	10/52	BOP1; FAM207A; EXOSC4; NOP53; MRM1; PPAN; RPS15; RRP7A; SART1; ZNF593
GO:0006839	mitochondrial transport	4.02	7.35e-05	7.48e-03	11/68	ALKBH7; ATP5F1D; BBC3; DNLZ; HSPA1A; MICALL2; SLC25A10; SLC25A6; TIMM13; TSPO; ZNF205
GO:0009141	nucleoside triphosphate metabolic process	2.91	4.83e-04	3.57e-02	13/111	ABCD1; ATP5F1D; UQCC3; GALK1; GUK1; HSPA1A; NDUFB7; NDUFS6; NDUFS7; NDUFS8; NME3; NUDT1; TSPO

Factor 4 : 49 significant GO terms

GeneSet	description	enrichRatio	pValue	FDR	GeneRatio	geneSymbols
GO:0060976	coronary vasculature development	4.74	7.08e-07	3.39e-05	13/29	ADAMTS6; APLN; HAND2; LTBP1; NRP1; PCSK5; PDGFRB; PRDM1; PRICKLE1; PTK7; SGCD; TBX5; TGFBR1
GO:0006929	substrate-dependent cell migration	4.23	2.77e-04	4.90e-03	8/20	FN1; ITGA11; NRP1; NRP2; SEMA3A; SNAI2; TNFRSF12A; VEGFC
GO:1900115	extracellular regulation of signal transduction	4.23	1.67e-03	2.05e-02	6/15	DKK3; FBN1; FBN2; GREM2; LTBP1; NBL1
GO:0071526	semaphorin-plexin signaling pathway	4.15	2.40e-05	6.51e-04	11/28	FLNA; GDNF; HAND2; NCAM1; NRP1; NRP2; PLXNC1; SEMA3A; SEMA3D; SEMA5A; SEMA7A
GO:0032963	collagen metabolic process	4.03	1.28e-11	1.30e-09	29/76	ADAMTS14; ADAMTS2; COL15A1; COL1A1; COL5A1; CTGF; CTSK; EMILIN1; F2R; FAP; P3H3; MFAP4; MMP10; MMP11; MMP13; MMP14; MMP16; MMP1; MMP2; MMP3; MMP9; MRC2; PDGFRB; PLOD2; RCN3; SERPINB7; SERPINH1; TGFB3; VIM
GO:0043062	extracellular structure organization	3.82	0.00e+00	0.00e+00	119/329	ADAM12; ADAM19; ADAMTS14; ADAMTS2; ADAMTS4; ADAMTS5; ADAMTSL2; AEBP1; ANTXR1; BGN; BMP1; CCDC80; COL10A1; COL11A1; COL12A1; COL15A1; COL16A1; COL18A1; COL1A1; COL1A2; COL22A1; COL24A1; COL3A1; COL4A1; COL4A2; COL5A1; COL5A2; COL5A3; COL6A1; COL6A2; COL6A3; COL7A1; COL8A1; COL8A2; COMP; CRISPLD2; CTGF; CTSK; CYR61; DCN; DDR2; DPP4; DPT; ECM2; EFEMP2; EGFL6; ELN; EMILIN1; FAP; FBLN1; FBLN2; FBN1; FBN2; FLRT2; FN1; FOXF2; FSCN1; GAS6; GREM1; HAPLN1; HAS2; HSPG2; HTRA1; ITGA11; ITGB5; JAM3; KLK2; KLK4; LAMA1; LAMA2; LAMA4; LAMB1; LAMC1; LCAT; LOXL2; LOX; LRP1; LUM; MATN3; MFAP2; MFAP4; MFAP5; MMP10; MMP11; MMP13; MMP14; MMP16; MMP1; MMP2; MMP3; MMP9; NID1; NID2; OLFML2A; PDGFRA; PDPN; PLA2G5; PLOD2; POSTN; PXDN; RECK; SDC1; SERPINE1; SERPINH1; SFRP2; SH3PXD2A; SH3PXD2B; SPARC; SULF1; SULF2; TGFB2; TGFBI; TGFBR1; THBS1; TIMP2; TLL1; TLL2; TNC; VCAN
GO:0060840	artery development	3.52	2.77e-07	1.50e-05	20/60	ADAMTS6; AKT3; COL3A1; COMP; GJA5; HAND2; LOXL1; LOX; LRP1; LTBP1; MYLK; NOG; NRP1; PDGFRB; PKD2; PRDM1; PRICKLE1; PRRX1; TGFB2; TGFBR1
GO:0007492	endoderm development	3.45	2.96e-06	9.64e-05	17/52	COL11A1; COL12A1; COL4A2; COL5A1; COL5A2; COL6A1; COL7A1; COL8A1; FN1; INHBA; ITGB5; LAMB1; LAMC1; MMP14; MMP2; MMP9; NOG
GO:0060348	bone development	3.37	5.46e-14	8.34e-12	45/141	COL12A1; COL1A1; COL6A1; COL6A2; COL6A3; COL7A1; COMP; CYP26B1; DCHS1; DLX5; RFLNA; RFLNB; FAT4; FBN1; FGF18; GPR68; GREM1; HAS2; HOXA11; LRRC17; MATN3; MMP13; MMP14; MMP16; MSX1; NPR2; PAX1; PDGFC; PITX2; PLS3; RAB23; RUNX2; SERPINH1; SFRP2; SFRP4; SH3PXD2B; SHOX2; SPARC; SULF1; SULF2; TGFB3; TMEM119; TNFSF11; TWIST1; XYLT1
GO:0060324	face development	3.28	1.02e-03	1.36e-02	9/29	COL1A1; CRISPLD2; DLX5; MMP2; MSX1; NOG; PDGFRA; TGFB3; WNT5A
GO:0090287	regulation of cellular response to growth factor stimulus	3.18	2.73e-14	5.56e-12	50/166	ADAMTS12; ADAMTSL2; APLN; ASPN; LDLRAD4; NREP; CD109; CDKN2B; CHST11; CYR61; DAB2; DCN; DKK3; DOK5; EMILIN1; FBN1; FBN2; FGF16; FGF18; FGF1; FSTL3; FZD1; GPC1; ADGRA2; GREM1; GREM2; HTRA1; HTRA3; JCAD; LTBP1; MSX1; NBL1; NOG; PMEPA1; RASL11B; RUNX2; SFRP2; SFRP4; SHISA2; SULF1; SULF2; TGFB1I1; TGFB3; TGFBR1; THBS1; TMEM204; VEGFC; WNT5A; ZEB1; ZNF423
GO:0010463	mesenchymal cell proliferation	3.14	4.32e-04	6.90e-03	11/37	DCHS1; FAT4; FGF7; FOXP2; HAND2; MSX1; PRRX1; SHOX2; WNT2; WNT5A; ZEB1
GO:0035924	cellular response to vascular endothelial growth factor stimulus	3.14	4.32e-04	6.90e-03	11/37	ADAMTS12; DCN; GAS1; ADGRA2; JCAD; NRP1; NRP2; PDGFRA; PDGFRB; PRKD1; VEGFC
GO:0003170	heart valve development	3.12	1.42e-04	2.95e-03	13/44	CYR61; DCHS1; ELN; EMILIN1; GJA5; HEYL; PRDM1; SHOX2; SLIT3; SNAI2; TBX5; TGFB2; TWIST1
GO:1904888	cranial skeletal system development	3.12	1.42e-04	2.95e-03	13/44	CHST11; MMP14; MMP16; PDGFRA; PRRX1; RAB23; RUNX2; SH3PXD2B; TBX15; TGFB2; TGFB3; TGFBR1; TWIST1
GO:0010171	body morphogenesis	3.07	1.72e-03	2.09e-02	9/31	COL1A1; CRISPLD2; DLX5; GREM2; MMP2; MSX1; NOG; PDGFRA; TGFB3
GO:0061448	connective tissue development	3.05	5.66e-15	1.54e-12	56/194	ACTA2; ADAMTS12; ADAMTS7; BMP1; BMP8A; BMP8B; CHST11; COL11A1; COL12A1; COL1A1; COL5A1; COL6A1; COL6A2; COL6A3; COL7A1; COMP; CTGF; CTSK; CYR61; EVC; RFLNA; RFLNB; FGF18; GDF6; GLI2; GREM1; HAND2; HOXA11; HOXA3; KLF7; LOXL2; LUM; MAF; MATN3; MMP13; MSX1; NKX3-2; NOG; PDGFRB; PRRX1; PTH1R; ROR2; RUNX2; SERPINB7; SERPINH1; SFRP2; SH3PXD2B; SHOX2; SNAI2; SULF1; SULF2; TGFBI; TGFBR1; WNT5A; WNT5B; ZEB1
GO:0071559	response to transforming growth factor beta	3.04	5.53e-11	5.00e-09	40/139	ADAMTSL2; ANKRD1; ASPN; LDLRAD4; NREP; CD109; CDKN2B; CHST11; CILP; COL1A1; COL1A2; COL3A1; COL4A2; DAB2; DKK3; EMILIN1; FBN1; FBN2; FERMT2; FNDC4; FYN; HTRA1; HTRA3; ITGB5; LRRC32; LTBP1; LTBP2; MXRA5; NOX4; PMEPA1; POSTN; RASL11B; TGFB1I1; TGFB2; TGFB3; TGFBR1; THBS1; WNT2; WNT5A; ZEB1
GO:0007178	transmembrane receptor protein serine/threonine kinase signaling pathway	2.90	6.15e-14	8.34e-12	56/204	ADAMTSL2; ASPN; BMP8A; BMP8B; LDLRAD4; NREP; CD109; CDKN2B; CHST11; CILP; COL1A2; COL3A1; COMP; CYR61; DAB2; DACT1; DKK3; DLX5; DSG4; EMILIN1; FBN1; FBN2; FERMT2; FSTL1; FSTL3; FST; FZD1; GDF6; GREM1; GREM2; HTRA1; HTRA3; INHBA; ITGB5; LRRC32; LTBP1; LTBP2; MSX1; NBL1; NOG; PMEPA1; RASL11B; ROR2; RUNX2; SFRP2; SFRP4; SULF1; TGFB1I1; TGFB2; TGFB3; TGFBR1; THBS1; VIM; WNT5A; ZEB1; ZNF423
GO:0048705	skeletal system morphogenesis	2.89	8.38e-12	9.75e-10	47/172	BMP1; CHST11; COL11A1; COL12A1; COL1A1; COL6A1; COL6A2; COL6A3; COL7A1; COMP; CTGF; CYP26B1; DLX5; RFLNA; RFLNB; FBN2; FGF18; GREM1; HAS2; HOXA11; HOXA3; HOXA7; HOXC8; MATN3; MMP13; MMP14; MMP16; MMP2; MSX1; NKX3-2; NOG; PAX1; PDGFRA; PRRX1; RAB23; ROR2; RUNX2; SERPINH1; SFRP2; SFRP4; SH3PXD2B; SHOX2; TBX15; TGFB3; TGFBR1; TWIST1; ZEB1
GO:0061383	trabecula morphogenesis	2.80	3.47e-03	3.76e-02	9/34	COL1A1; FBN2; GREM1; HEG1; MMP2; NOG; NRG1; TGFB2; TGFBR1
GO:0071772	response to BMP	2.79	3.26e-07	1.66e-05	28/106	ADAMTS12; ADAMTS7; BMP8A; BMP8B; COMP; CYR61; DLX5; DSG4; FBN1; FSTL1; FSTL3; FZD1; GDF6; GREM1; GREM2; HEYL; HTRA1; HTRA3; MSX1; NBL1; NOG; ROR2; RUNX2; SFRP2; SFRP4; SULF1; WNT5A; ZNF423
GO:0001503	ossification	2.79	1.55e-15	6.33e-13	67/254	ANKH; ASPN; BMP1; BMP8A; BMP8B; CDH11; CLEC11A; COL11A1; COL1A1; COL5A2; COL6A1; COMP; CTGF; CTHRC1; CTSK; CYR61; DCHS1; DDR2; DLX5; RFLNA; RFLNB; FAT4; FBN2; FGF18; FSTL3; FZD1; GLI2; GPNMB; GREM1; HAND2; HOXA3; ID3; IGF2; ITGA11; LRRC17; MMP13; MMP14; MMP16; MMP2; MMP9; MN1; MRC2; NOG; NPR2; OMD; PDLIM7; PRKD1; PTH1R; ROR2; RUNX2; SEMA7A; SFRP2; SH3PXD2B; SHOX2; SNAI2; SPARC; TGFB2; TGFB3; TMEM119; TNC; TNFSF11; TNN; TWIST1; TWIST2; VCAN; WNT5A; XYLT1
GO:0060021	roof of mouth development	2.76	7.77e-05	1.86e-03	17/65	BNC2; DLX5; FOXF2; FZD1; HAND2; INHBA; LRRC32; MSC; MSX1; PDGFRA; PRRX1; SNAI2; TGFB2; TGFB3; TGFBR1; TWIST1; WNT5A
GO:0048706	embryonic skeletal system development	2.75	1.85e-06	7.94e-05	25/96	CHST11; COL11A1; COL1A1; HOXA11; HOXA3; HOXA7; HOXC6; MMP14; MMP16; NKX3-2; NOG; PCSK5; PDGFRA; PRRX1; RUNX2; SHOX2; SULF1; SULF2; TBX15; TGFB3; TGFBR1; TWIST1; WNT5A; XYLT1; ZEB1
GO:0042476	odontogenesis	2.72	2.28e-06	8.83e-05	25/97	ADAMTS5; ASPN; COL1A1; COL1A2; FAM20A; FOXO1; GLI2; HAND2; HTRA1; ID3; INHBA; KLK4; LAMB1; LHX8; MSX1; PDGFRA; PITX2; RUNX2; SDC1; SERPINE1; TGFB2; TGFB3; TNC; TNFSF11; TWIST1
GO:0050919	negative chemotaxis	2.72	4.28e-03	4.53e-02	9/35	FLRT2; NRG1; NRP2; SEMA3A; SEMA3D; SEMA5A; SEMA7A; SLIT3; WNT5A
GO:0006022	aminoglycan metabolic process	2.62	2.08e-06	8.47e-05	27/109	BGN; CHPF; CHST11; CHST3; CHST6; CHSY3; CSPG4; DCN; DSEL; DSE; GPC1; GPC6; HAS2; HS3ST3A1; HSPG2; KERA; CEMIP; LUM; OGN; OMD; PDGFRB; PRELP; SDC1; SDC2; CEMIP2; VCAN; XYLT1
GO:0003205	cardiac chamber development	2.60	1.04e-06	4.71e-05	29/118	ADAMTS6; COL11A1; CYR61; FZD1; GJA5; HAND2; HEG1; HEYL; LTBP1; MYL3; NOG; NRG1; NRP1; NRP2; PCSK5; PRDM1; PTK7; SALL1; SALL4; SFRP2; SHOX2; SLIT3; TBX5; TGFB2; TGFBR1; TPM1; WNT2; WNT5A; ZFPM2
GO:0007164	establishment of tissue polarity	2.54	1.95e-03	2.30e-02	12/50	CTHRC1; DAB2; DACT1; FOXF2; FZD1; GPC6; PRICKLE1; PRICKLE2; PTK7; ROR2; SFRP2; WNT5A
GO:0060485	mesenchyme development	2.53	2.64e-09	2.15e-07	45/188	ACTA1; ACTA2; BNC2; LDLRAD4; COL1A1; DAB2; DCHS1; EDNRA; RFLNB; FN1; FOXF2; GDNF; GREM1; HAND2; HAS2; HEYL; LOXL2; MSX1; NOG; NRG1; NRP1; NRP2; PAX1; PDGFRB; PDPN; PITX2; PKD2; PTK7; S100A4; SEMA3A; SEMA3D; SEMA5A; SEMA7A; SFRP2; SNAI2; TBX5; TGFB1I1; TGFB2; TGFB3; TGFBR1; TWIST1; WNT2; WNT5A; ZEB2; ZFPM2
GO:0071774	response to fibroblast growth factor	2.48	1.48e-04	3.01e-03	19/81	APLN; COL1A1; CTGF; FAT4; FGF16; FGF18; FGF1; FGF7; FLRT2; GPC1; NOG; POSTN; RUNX2; SHISA2; SULF1; SULF2; THBS1; TNC; WNT5A
GO:0030323	respiratory tube development	2.45	5.67e-06	1.77e-04	28/121	ADAMTS2; ADAMTSL2; CRISPLD2; CTGF; FGF18; FGF1; FGF7; FOXP2; FSTL3; GLI2; HEG1; LAMA1; LOX; MMP14; NOG; PCSK5; PDGFRA; PDGFRB; PDPN; PTK7; RCN3; SPARC; TBX5; TGFB3; TNC; WNT2; WNT5A; ZFPM2
GO:0048736	appendage development	2.43	6.71e-06	2.02e-04	28/122	CHST11; COMP; CYP26B1; DLX5; EN1; FBN2; GJA5; GLI2; GREM1; HAND2; HOXA10; HOXA11; MSX1; NOG; PCSK5; PITX2; PRRX1; RECK; ROR2; RUNX2; SALL1; SALL4; SFRP2; SHOX2; TBX5; TGFB2; TWIST1; WNT5A
GO:0007229	integrin-mediated signaling pathway	2.40	5.01e-04	7.84e-03	17/75	BST1; CD177; COL16A1; COL3A1; CTGF; DAB2; FBLN1; FERMT2; FLNA; ITGA11; ITGB5; ITGBL1; LIMS2; NRP1; PRKD1; SEMA7A; THY1
GO:0048645	animal organ formation	2.39	3.30e-03	3.63e-02	12/53	FGF1; GDNF; GLI2; HAND2; HOXA11; HOXA3; NKX3-2; NOG; SULF1; TBX5; WNT2; WNT5A
GO:0031589	cell-substrate adhesion	2.33	3.42e-09	2.53e-07	52/236	ADAMTS12; ANTXR1; AXL; BST1; CCDC80; COL16A1; COL1A1; COL3A1; COL5A3; COL8A1; CTGF; CYR61; DLC1; ECM2; EDIL3; EGFL6; EMILIN1; EPDR1; FBLN1; FBLN2; FERMT2; FLNA; FN1; GAS6; GREM1; HAS2; HOXA7; ITGA11; ITGB5; ITGBL1; JAM3; AJUBA; LAMB1; LAMC1; LGALS1; MMP14; NID1; NID2; NRP1; PDPN; PLAU; POSTN; PPFIA2; S100A10; SERPINE1; SGCE; SNED1; SPOCK1; THBS1; THY1; TNFRSF12A; TNN
GO:0060541	respiratory system development	2.27	1.80e-05	5.24e-04	29/135	ADAMTS2; ADAMTSL2; CRISPLD2; CTGF; DLX5; FGF18; FGF1; FGF7; FOXP2; FSTL3; GLI2; HEG1; LAMA1; LOX; MMP14; MSC; NOG; PDGFRA; PDGFRB; PDPN; PTK7; RCN3; SPARC; TBX5; TGFB3; TNC; WNT2; WNT5A; ZFPM2
GO:0031214	biomineral tissue development	2.23	1.74e-04	3.45e-03	23/109	ANKH; ASPN; COL1A1; COMP; CYR61; DDR2; RFLNA; RFLNB; FAM20A; FBN2; FOXO1; GAS6; GPNMB; GREM1; HOXA3; KLK4; MMP13; OMD; PTH1R; ROR2; TGFB3; TMEM119; TWIST1
GO:0021915	neural tube development	2.21	9.52e-04	1.29e-02	18/86	CTHRC1; DACT1; DCHS1; DLC1; EN1; FZD1; GLI2; GPR161; NOG; PKD2; PRICKLE1; PTK7; SALL4; SFRP2; TGFB2; TWIST1; WNT5A; ZEB2
GO:0003007	heart morphogenesis	2.20	2.94e-06	9.64e-05	37/178	ANKRD1; COL11A1; COL5A1; CYR61; DCHS1; DLC1; ELN; FAT4; FLRT2; FZD1; GJA5; HAND2; HAS2; HEG1; HEYL; MICAL2; MICALCL; MSX1; MYL3; NOG; NRG1; NRP1; NRP2; PITX2; PKD2; SFRP2; SHOX2; SLIT3; SNAI2; TBX5; TGFB2; TGFB3; TGFBR1; TPM1; TWIST1; WNT2; WNT5A; ZFPM2
GO:0198738	cell-cell signaling by wnt	2.13	6.09e-08	4.13e-06	53/263	AMOTL2; APCDD1; AXL; BICC1; CDH2; COL1A1; CPZ; CTHRC1; DAB2; DACT1; DKK3; DLX5; FERMT2; FOXO1; FZD1; GNG2; GPC6; ADGRA2; GREM1; HECW1; HIC1; LGR5; LRP1; MITF; NKD2; NOG; NXN; PKD2; PRICKLE1; PRICKLE2; PTK7; RBMS3; RECK; ROR2; RSPO1; SALL1; SDC1; SEMA5A; SFRP2; SFRP4; SHISA2; SHISA6; SNAI2; SULF1; SULF2; TBX18; TGFB1I1; TNN; WISP1; WNT2; WNT5A; WNT5B; ZEB2
GO:2000027	regulation of animal organ morphogenesis	2.11	3.12e-05	8.19e-04	32/160	ASPN; CTHRC1; DAB2; DACT1; FGF1; FGF7; FOXP2; FZD1; GDNF; GPC6; GREM1; HAND2; HOXA11; LIMS2; MSX1; NOG; PRICKLE1; PRICKLE2; PTK7; ROR2; RUNX2; SFRP2; SNAI2; SULF1; SULF2; TBX5; TGFB2; TGFB3; TGFBR1; TWIST1; WNT2; WNT5A
GO:1901136	carbohydrate derivative catabolic process	2.11	5.28e-04	7.96e-03	22/110	ADAMTS12; BGN; LINC00473; CSPG4; DCN; ENPP4; GPC1; GPC6; HSPG2; KERA; CEMIP; LUM; NT5E; NUDT10; NUDT11; OGN; OMD; PDE10A; PRELP; SDC1; SDC2; CEMIP2; VCAN
GO:0001763	morphogenesis of a branching structure	2.10	8.29e-05	1.93e-03	29/146	ADAMTS16; CCL11; COL4A1; DCHS1; EDNRA; ERMN; FAT4; FGF1; FGF7; GDNF; GLI2; GREM1; HOXA11; HOXD11; LAMA1; MMP14; NOG; NRP1; PKD2; PRDM1; SALL1; SEMA3A; SFRP2; SHOX2; SNAI2; SULF1; TNC; WNT2; WNT5A
GO:0002576	platelet degranulation	2.09	2.50e-03	2.91e-02	17/86	CD109; F13A1; FLNA; FN1; GAS6; IGF2; ISLR; PCDH7; RARRES2; SERPINE1; SERPING1; SPARC; TGFB2; TGFB3; THBS1; TIMP3; VEGFC
GO:0045995	regulation of embryonic development	2.06	3.80e-03	4.06e-02	16/82	COL5A1; COL5A2; FZD1; GDNF; GPR161; LAMA1; LAMA2; LAMA4; NRK; TENM4; PTK7; SFRP2; SULF1; TBX18; WNT2; WNT5A
GO:0007369	gastrulation	2.04	1.16e-03	1.50e-02	21/109	APLN; COL11A1; COL12A1; COL4A2; COL5A1; COL5A2; COL6A1; COL7A1; COL8A1; FN1; HOXA11; INHBA; ITGB5; LAMB1; MMP14; MMP2; MMP9; NOG; TENM4; SFRP2; WNT5A
GO:0055123	digestive system development	2.02	1.31e-03	1.67e-02	21/110	CLMP; COL3A1; DACT1; DCHS1; FAT4; FOXF2; GLI2; IGF2; NKX3-2; PCSK5; PDGFC; PDGFRA; PRDM1; RARRES2; SALL1; SCT; SFRP2; SHOX2; TGFB2; TGFB3; WNT5A

Factor 5 : 106 significant GO terms

GeneSet	description	enrichRatio	pValue	FDR	GeneRatio	geneSymbols
GO:0009595	detection of biotic stimulus	8.95	1.30e-07	2.20e-06	9/17	CD1D; CRTAM; LY96; NLRP3; TLR1; TLR2; TLR4; TLR6; TREM2
GO:0045730	respiratory burst	7.35	2.69e-07	4.30e-06	10/23	CYBA; CYBB; HCK; NCF1; NCF2; NCF4; PIK3CD; PIK3CG; SLAMF8; SLC11A1
GO:0097242	amyloid-beta clearance	7.25	8.26e-05	8.97e-04	6/14	APOE; C3; ITGAM; ITGB2; MARCO; MSR1
GO:0010324	membrane invagination	6.96	2.44e-09	5.08e-08	14/34	ABCA1; AIF1; ARHGAP25; BIN2; C3; CD300A; FCER1G; FCGR1A; FCGR2B; ITGAM; ITGB2; MSR1; NCKAP1L; TREM2
GO:0055094	response to lipoprotein particle	6.76	1.31e-04	1.38e-03	6/15	ABCA1; APOE; FCER1G; ITGB2; TLR4; TLR6
GO:0002269	leukocyte activation involved in inflammatory response	6.64	2.35e-07	3.82e-06	11/28	AIF1; FPR2; ITGAM; ITGB2; MMP8; PTPRC; SNCA; TLR2; TLR6; TLR7; TLR8
GO:0071402	cellular response to lipoprotein particle stimulus	6.34	1.99e-04	2.03e-03	6/16	ABCA1; APOE; FCER1G; ITGB2; TLR4; TLR6
GO:0032613	interleukin-10 production	6.11	5.99e-08	1.08e-06	13/36	VSIR; CD28; CD83; FCER1G; FCGR2B; HGF; LGALS9; LILRB1; MMP8; PDCD1LG2; SASH3; TLR2; TLR4
GO:0090382	phagosome maturation	6.04	9.06e-04	8.02e-03	5/14	CORO1A; MYO7A; P2RX7; RAB39A; SLAMF8
GO:0042116	macrophage activation	6.02	6.46e-12	1.81e-10	21/59	AIF1; CD74; CEBPA; FCGR2B; FPR2; HAVCR2; ITGAM; ITGB2; MMP8; PTPRC; SLC11A1; SNCA; SUCNR1; TLR1; TLR2; TLR4; TLR6; TLR7; TLR8; TYROBP; VSIG4
GO:0150076	neuroinflammatory response	5.90	9.77e-09	1.85e-07	15/43	AIF1; CD200R1; FPR2; IL18; IL1B; ITGAM; ITGB2; MMP8; PTPRC; SNCA; TLR2; TLR6; TLR7; TLR8; TNFRSF1B
GO:0032623	interleukin-2 production	5.88	3.27e-09	6.48e-08	16/46	CARD11; CARD9; CD28; CD4; CD80; CD83; CD86; FCER1G; HAVCR2; IL18; IL1A; IL1B; PTPRC; SASH3; SLC11A1; VSIG4
GO:0045576	mast cell activation	5.88	3.27e-09	6.48e-08	16/46	BTK; CD226; CD300A; CD300LF; CD84; ADGRE2; FCER1G; FCGR2B; FGR; HMOX1; LAT2; LCP2; LGALS9; LYN; PIK3CD; PIK3CG
GO:0006909	phagocytosis	5.87	0.00e+00	0.00e+00	50/144	ABCA1; AIF1; ARHGAP25; AXL; BIN2; C2; C3; CCL2; CD14; CD300A; CD300LF; CEACAM4; CLEC7A; CORO1A; CYBA; DOCK2; FCER1G; FCGR1A; FCGR2A; FCGR2B; FCGR2C; FCGR3A; FGR; HCK; IL1B; IRF8; ITGAM; ITGB2; ITGB3; LYN; MARCO; MERTK; MSR1; MYO1G; MYO7A; NCF2; NCF4; NCKAP1L; P2RX7; P2RY6; PLD4; PTPRC; RAB39A; SIRPA; SIRPB1; SLC11A1; TLR2; TREM2; VAV1; WAS; WIPF1
GO:0002448	mast cell mediated immunity	5.80	3.78e-07	5.80e-06	12/35	BTK; CD300A; CD84; ADGRE2; FCER1G; FGR; HMOX1; LAT2; LGALS9; LYN; PIK3CD; PIK3CG
GO:0032418	lysosome localization	5.80	3.78e-07	5.80e-06	12/35	BTK; CD300A; CD84; ADGRE2; FCER1G; FGR; HMOX1; LAT2; LGALS9; LYN; PIK3CD; PIK3CG
GO:0042107	cytokine metabolic process	5.33	1.16e-11	3.14e-10	23/73	CARD11; CARD9; CD28; CD4; CD80; CD86; CX3CR1; CYBB; EBI3; HMOX1; IL18; IL1A; IL1B; INPP5D; LILRB1; PTAFR; PTPRC; SPN; TLR1; TLR4; TLR6; TLR7; TLR8
GO:0050690	regulation of defense response to virus by virus	5.20	5.62e-03	3.75e-02	4/13	CD28; CD4; DOCK2; HCK
GO:0071706	tumor necrosis factor superfamily cytokine production	5.18	1.84e-14	8.82e-13	30/98	ACP5; ADAM8; AXL; VSIR; CARD9; CCL3; CD14; CD86; CLEC4A; CX3CR1; CYBA; CYBB; FCER1G; GPNMB; HAVCR2; LGALS9; LILRA2; LILRA4; LILRB1; LY96; MMP8; PTAFR; PTPN22; PTPRC; SASH3; SIRPA; SPN; TLR1; TLR2; TLR4
GO:0036230	granulocyte activation	5.16	0.00e+00	0.00e+00	79/259	ADAM8; ALDH3B1; ALOX5; ARHGAP9; ATP8B4; BIN2; MCEMP1; C3AR1; C3; C5AR1; CCL3; CD14; CD300A; CD33; CD53; CD68; ADGRE5; ADA2; CHIT1; CLEC5A; COTL1; CR1; CTSC; CTSD; CTSS; CTSZ; CYBA; CYBB; DOCK2; DOK3; ADGRE3; FCER1G; FCGR2A; FCGR2B; FCGR2C; FCGR3B; FGL2; FGR; FPR1; FPR2; FTL; GMFG; GPR84; HK3; HPSE; HVCN1; IL18; ITGAM; ITGAX; ITGB2; KCNAB2; LILRA2; LILRA3; LRMP; LYZ; MMP8; MNDA; NCKAP1L; NFAM1; OLR1; OSCAR; PLAUR; PLAU; PRAM1; PTAFR; PTPRC; RNASE2; SIGLEC14; SIGLEC5; SIGLEC9; SIRPA; SIRPB1; SLC11A1; SLC2A5; TCIRG1; TLR2; TNFRSF1B; TRPM2; TYROBP; VNN1
GO:0006968	cellular defense response	5.11	6.48e-07	9.58e-06	13/43	C5AR1; CCR5; CD300C; CLEC5A; CX3CR1; LSP1; LY96; MNDA; NCF1; NCF2; SPN; TCIRG1; TYROBP
GO:0002446	neutrophil mediated immunity	5.03	0.00e+00	0.00e+00	75/252	ADAM8; ALDH3B1; ALOX5; ARHGAP9; ATP8B4; BIN2; MCEMP1; C3AR1; C3; C5AR1; CD14; CD300A; CD33; CD53; CD68; ADGRE5; ADA2; CHIT1; CLEC5A; COTL1; CR1; CTSC; CTSD; CTSS; CTSZ; CYBA; CYBB; DOCK2; DOK3; ADGRE3; FCER1G; FCGR2A; FCGR2C; FCGR3B; FGL2; FGR; FPR1; FPR2; FTL; GMFG; GPR84; HK3; HPSE; HVCN1; ITGAM; ITGAX; ITGB2; KCNAB2; LILRA3; LRMP; LYZ; MMP8; MNDA; NCKAP1L; NFAM1; OLR1; OSCAR; PLAUR; PLAU; PRAM1; PTAFR; PTPRC; RNASE2; SIGLEC14; SIGLEC5; SIGLEC9; SIRPA; SIRPB1; SLC11A1; SLC2A5; TCIRG1; TLR2; TNFRSF1B; TRPM2; TYROBP; VNN1
GO:0032615	interleukin-12 production	4.97	1.71e-05	2.21e-04	10/34	ACP5; CD40; CMKLR1; IRF5; IRF8; LGALS9; LILRB1; TLR2; TLR4; TLR8
GO:0001562	response to protozoan	4.97	2.42e-03	1.88e-02	5/17	CCDC88B; CD40; CLEC7A; IRF8; SLC11A1
GO:0032633	interleukin-4 production	4.91	5.11e-05	5.85e-04	9/31	CD28; CD83; CD86; CLECL1; FCER1G; HAVCR2; LGALS9; NLRP3; SASH3
GO:0032637	interleukin-8 production	4.83	3.42e-06	4.81e-05	12/42	CD14; IL1B; LGALS9; LILRA2; PTPN22; PTPRC; TLR1; TLR2; TLR4; TLR6; TLR7; TLR8
GO:0019882	antigen processing and presentation	4.80	1.89e-11	4.80e-10	25/88	CD1D; CD209; CD74; CLEC4A; CTSD; CTSL; CTSS; FCER1G; FCGR1A; FCGR1B; FCGR2B; HLA-DMB; HLA-DOA; HLA-DPA1; HLA-DPB1; HLA-DQA1; HLA-DQB1; HLA-DRA; HLA-DRB1; HLA-DRB5; IFI30; MARCH1; SLC11A1; TREM2; WAS
GO:0071216	cellular response to biotic stimulus	4.69	2.22e-16	1.29e-14	38/137	ABCA1; AXL; BTK; CARD16; CASP1; CCL2; CCL3; CCR5; CD14; CD180; CD40; CD80; CD86; CX3CR1; FCGR2B; HAMP; HAVCR2; HCK; IL18; IL1B; IRF8; LILRA2; LILRB1; LY86; LY96; LYN; MRC1; NLRP3; PDCD1LG2; PTAFR; PTPN22; SIRPA; TLR1; TLR2; TLR4; TLR6; TNFRSF1B; TREM2
GO:0070661	leukocyte proliferation	4.59	0.00e+00	0.00e+00	54/199	AIF1; BTK; VSIR; CARD11; CCDC88B; CCL8; CD180; CD1D; CD209; CD28; CD300A; CD40; CD4; CD74; CD80; CD86; CLECL1; CORO1A; CRTAM; CSF1; DOCK2; DOCK8; EBI3; FCGR2B; GAPT; GPNMB; GPR183; HAVCR2; HLA-DMB; HLA-DPA1; HLA-DPB1; IL18; IL1B; INPP5D; LGALS9; LILRB1; LST1; LYN; MNDA; NCKAP1L; P2RX7; PDCD1LG2; PIK3CG; PTPN22; PTPRC; RASAL3; SASH3; SLC11A1; SPN; TGFBR2; TLR4; TNFRSF1B; TNFSF13B; VSIG4
GO:0032635	interleukin-6 production	4.52	4.69e-10	1.03e-08	23/86	CARD9; CD200R1; CYBA; FCER1G; HAVCR2; HGF; IL18; IL1B; INPP5D; LGALS9; LILRA2; MMP8; NCKAP1L; P2RX7; PTAFR; PTPN22; SIRPA; TLR1; TLR2; TLR4; TLR6; TLR7; TLR8
GO:0002764	immune response-regulating signaling pathway	4.49	0.00e+00	0.00e+00	77/290	BLK; BTK; THEMIS2; C3AR1; C5AR1; CARD11; CARD9; CD14; CD200R1; CD209; CD226; CD28; CD300A; CD300LF; CD33; CD40; CD4; CLEC4A; CLEC4E; CLEC7A; CMKLR1; CR1; CTSS; CYBA; FCER1G; FCGR1A; FCGR1B; FCGR2A; FCGR2B; FCGR2C; FCGR3A; FGR; FPR1; FPR2; FPR3; FYB1; HAVCR2; HCK; HLA-DPA1; HLA-DPB1; HLA-DQA1; HLA-DQB1; HLA-DRA; HLA-DRB1; HLA-DRB5; INPP5D; ITGAM; ITGB2; KLHL6; LAT2; LCP2; LGALS9; LILRA2; LILRA4; LILRB1; LILRB4; LPXN; LY96; LYN; MARCO; MNDA; MYO1G; NCKAP1L; NFAM1; PIK3AP1; PIK3CD; PRAM1; PTPN22; PTPRC; TLR1; TLR2; TLR4; TLR6; TLR7; TLR8; VAV1; WAS; WIPF1
GO:0050867	positive regulation of cell activation	4.48	0.00e+00	0.00e+00	58/219	ADAM8; AIF1; AXL; BTK; VSIR; CARD11; CCDC88B; CCL2; CD1D; CD209; CD226; CD28; CD40; CD4; CD74; CD80; CD83; CD86; CEBPA; CLECL1; CORO1A; DOCK8; EBI3; FCER1G; FGR; GPR183; HAVCR2; HLA-DMB; HLA-DPA1; HLA-DPB1; IL18; IL1B; INPP5D; ITGAM; ITGB2; LGALS9; LILRA2; LILRB1; LILRB4; LYN; MMP8; NCKAP1L; NLRP3; PDCD1LG2; PIK3R6; PLEK; PTAFR; PTPRC; RASAL3; SASH3; SIRPA; SIRPB1; TGFBR2; TLR4; TLR6; TNFSF13B; VAV1; VNN1
GO:0071887	leukocyte apoptotic process	4.48	4.50e-08	8.32e-07	18/68	ADAM8; AXL; BIRC7; BTK; CCR5; CD74; CTSL; DOCK8; FCER1G; GIMAP8; HCLS1; LGALS9; LILRB1; LYN; MERTK; P2RX7; PIK3CD; SLC46A2
GO:0032612	interleukin-1 production	4.42	1.30e-07	2.20e-06	17/65	ABCA1; ACP5; CARD16; CASP1; CCL3; CX3CR1; HAVCR2; IL1B; LGALS9; LILRA2; NLRP3; P2RX7; SIRPA; SUCNR1; TLR4; TLR6; TLR8
GO:0035587	purinergic receptor signaling pathway	4.38	7.60e-04	6.80e-03	7/27	ADORA3; GPR34; P2RX7; P2RY12; P2RY13; P2RY6; PTAFR
GO:0034341	response to interferon-gamma	4.33	2.71e-13	9.66e-12	33/129	AIF1; CASP1; CCL2; CCL3L1; CCL3L3; CCL3; CCL4L1; CCL8; CD40; CIITA; CXCL16; DAPK1; FCGR1A; FCGR1B; HCK; HLA-DPA1; HLA-DPB1; HLA-DQA1; HLA-DQB1; HLA-DRA; HLA-DRB1; HLA-DRB5; IFI30; IRF5; IRF8; LGALS9; MRC1; PTAFR; SIRPA; SLC11A1; SNCA; TLR2; TLR4; WAS
GO:0002285	lymphocyte activation involved in immune response	4.31	2.45e-10	5.53e-09	25/98	APBB1IP; CD180; CD28; CD40; CD80; CD86; CLEC4E; CORO1A; DOCK10; FCER1G; FCGR2B; GAPT; GPR183; HAVCR2; HLA-DMB; IL18; LGALS9; LILRB1; MFNG; NLRP3; PTGER4; PTPRC; SLC11A1; SPN; TLR4
GO:0032609	interferon-gamma production	4.23	4.52e-09	8.76e-08	22/88	AXL; VSIR; CD14; CD226; EBI3; HAVCR2; HLA-DPA1; HLA-DPB1; IL18; IL1B; IRF8; LGALS9; LILRB1; PDCD1LG2; PTPN22; SASH3; SIRPA; SLC11A1; SPN; TLR4; TLR7; TLR8
GO:0032606	type I interferon production	4.23	3.53e-05	4.37e-04	11/44	CD14; HAVCR2; IRF5; LILRA4; LILRB1; PTPN22; SIRPA; TLR2; TLR4; TLR7; TLR8
GO:0001773	myeloid dendritic cell activation	4.23	5.23e-03	3.52e-02	5/20	DOCK2; HAVCR2; SPI1; TGFBR2; DCSTAMP
GO:0033028	myeloid cell apoptotic process	4.23	5.23e-03	3.52e-02	5/20	CCR5; CLEC5A; CTSL; FCER1G; PIK3CD
GO:0090077	foam cell differentiation	4.23	2.23e-03	1.78e-02	6/24	ABCA1; CSF1; IL18; ITGB3; MSR1; SOAT1
GO:0034113	heterotypic cell-cell adhesion	4.13	4.43e-05	5.23e-04	11/45	CD1D; CD200R1; GLDN; IL1B; ITGA4; ITGAD; ITGAX; ITGB2; ITGB3; PTPRC; SIRPA
GO:0002532	production of molecular mediator involved in inflammatory response	4.12	1.01e-04	1.08e-03	10/41	ADCY7; ALOX5; BTK; FCER1G; GPSM3; LYN; SIRPA; SLAMF8; TLR4; TLR6
GO:0030865	cortical cytoskeleton organization	4.06	2.79e-03	2.09e-02	6/25	FMNL1; FMNL2; NCKAP1L; PLEK; WAS; WIPF1
GO:0050663	cytokine secretion	4.00	2.73e-13	9.66e-12	36/152	ABCA1; CARD11; CARD16; CASP1; CCL3; CD14; CD200R1; CLEC4E; CLEC5A; CLECL1; CRTAM; CSF1R; FCGR2B; FGR; FFAR4; HAVCR2; IL1A; IL1B; LCP2; LGALS9; LILRA2; LILRB1; LYN; MMP8; NLRP3; OSM; P2RX7; PTGER4; PTPN22; SRGN; TLR1; TLR2; TLR4; TLR6; TLR8; TNFRSF1B
GO:0002694	regulation of leukocyte activation	3.98	0.00e+00	0.00e+00	79/336	ADAM8; AIF1; AXL; BTK; VSIR; CARD11; CCDC88B; CCL2; CD1D; CD209; CD226; CD28; CD300A; CD300LF; CD40; CD4; CD74; CD80; CD83; CD84; CD86; CEBPA; CLECL1; CORO1A; CR1; DOCK8; EBI3; ADGRE2; FCER1G; FCGR2B; FGR; GPNMB; GPR183; HAVCR2; HLA-DMB; HLA-DOA; HLA-DPA1; HLA-DPB1; HMOX1; IL18; IL1B; INPP5D; ITGAM; ITGB2; LGALS9; LILRB1; LILRB4; LST1; LYN; MERTK; MMP8; MNDA; NCKAP1L; NFAM1; NLRP3; PDCD1LG2; PIK3R6; PRAM1; PTAFR; PTPN22; PTPRC; RASAL3; SAMSN1; SASH3; SIRPA; SIRPB1; SLAMF8; SLC46A2; SNCA; SPN; TGFBR2; TLR4; TLR6; TNFAIP8L2; TNFRSF1B; TNFSF13B; VAV1; VNN1; VSIG4
GO:0002449	lymphocyte mediated immunity	3.96	1.83e-13	7.08e-12	37/158	BTK; C1QA; C1QB; C1QC; C2; C3; CD1D; CD226; CD28; CD40; CD74; CORO1A; CR1; CRTAM; CTSC; FCER1G; FCGR2B; GAPT; HAVCR2; HLA-DQB1; IL18; IL1B; INPP5D; LGALS9; LILRB1; MYO1G; NLRP3; P2RX7; PIK3R6; POU2F2; PTPRC; SASH3; SLC11A1; TLR8; TNFRSF1B; VAV1; WAS
GO:0007159	leukocyte cell-cell adhesion	3.94	0.00e+00	0.00e+00	54/232	ADAM8; AIF1; VSIR; CARD11; CCDC88B; CCL2; CD1D; CD209; CD28; CD300A; CD4; CD74; CD80; CD83; CD86; CLECL1; CORO1A; CX3CR1; DOCK8; EBI3; FCGR2B; FERMT3; GPNMB; HAVCR2; HLA-DMB; HLA-DPA1; HLA-DPB1; IL18; IL1B; ITGA4; ITGB2; LGALS9; LILRB1; LILRB4; LYN; NCKAP1L; NLRP3; PDCD1LG2; PIK3R6; PTAFR; PTPN22; PTPRC; RASAL3; SASH3; SELPLG; SIRPA; SIRPB1; SPN; TGFBR2; TNFAIP8L2; TNFSF13B; VAV1; VNN1; VSIG4
GO:0002521	leukocyte differentiation	3.86	0.00e+00	0.00e+00	73/320	ADAM8; AXL; BTK; VSIR; C1QC; CARD11; CCL3; CCR1; CD1D; CD28; CD4; CD74; CD80; CD83; CD86; CEBPA; CLEC4E; CR1; CSF1R; CSF1; DOCK10; DOCK2; EVI2B; FCER1G; FCGR2B; GAB3; GPR183; HCLS1; HLA-DOA; IKZF1; IL18; INPP5D; ITGA4; LGALS9; LILRB1; LILRB4; NRROS; LYL1; LYN; MAFB; MERTK; MFNG; MITF; NCKAP1L; NFAM1; NLRP3; OSCAR; PDE1B; PIK3CD; PIK3R6; POU2F2; PTGER4; PTPN22; PTPRC; RASSF2; SASH3; SLAMF8; SLC46A2; SPI1; SPN; TGFBR2; TLR2; TLR4; DCSTAMP; TMEM176A; TMEM176B; TNFSF8; TREM2; TRPM2; TYROBP; UBASH3B; VAV1; VNN1
GO:0002250	adaptive immune response	3.81	0.00e+00	0.00e+00	60/266	ADCY7; BTK; C1QA; C1QB; C1QC; C2; C3; CD1D; CD209; CD226; CD28; CD40; CD48; CD4; CD74; CD80; CD84; CD86; CLEC4A; CR1; CRTAM; CTSC; CTSL; CTSS; EBI3; ADGRE1; FCER1G; FCGR1B; FCGR2B; GAPT; GPR183; HAVCR2; HLA-DQB1; IL18; IL1B; INPP5D; KLHL6; LAT2; LILRA1; LILRA3; LILRB1; LILRB4; LILRB5; LYN; MYO1G; NLRP3; P2RX7; PIK3CD; PIK3CG; POU2F2; PTPRC; SAMSN1; SASH3; SLC11A1; SPN; TLR4; TLR8; TNFRSF1B; TNFSF13B; WAS
GO:0050866	negative regulation of cell activation	3.80	2.38e-10	5.53e-09	29/129	APOE; AXL; BTK; VSIR; CD300A; CD300LF; CD74; CD80; CD84; CD86; FCGR2B; GPNMB; HAVCR2; HMOX1; INPP5D; LGALS9; LILRB1; LST1; LYN; MERTK; MNDA; PDCD1LG2; PTPN22; PTPRC; SAMSN1; SPN; TNFAIP8L2; UBASH3B; VSIG4
GO:0042110	T cell activation	3.76	0.00e+00	0.00e+00	69/310	ADAM8; AIF1; JAML; APBB1IP; VSIR; CARD11; CCDC88B; CCL2; CD1D; CD209; CD28; CD300A; CD4; CD74; CD80; CD83; CD86; CLEC4A; CLEC4E; CLEC7A; CLECL1; CORO1A; CR1; CRTAM; DOCK2; DOCK8; EBI3; FCER1G; FCGR2B; GPNMB; GPR183; HAVCR2; HLA-DMB; HLA-DOA; HLA-DPA1; HLA-DPB1; IL18; IL1B; LGALS9; LILRB1; LILRB4; LYN; MAFB; NCKAP1L; NLRP3; P2RX7; PDCD1LG2; PIK3CD; PIK3CG; PIK3R6; PTGER4; PTPN22; PTPRC; RASAL3; SASH3; SIRPA; SIRPB1; SLC11A1; SLC46A2; SPN; TGFBR2; TNFAIP8L2; TNFRSF1B; TNFSF13B; TNFSF8; VAV1; VNN1; VSIG4; WAS
GO:0001819	positive regulation of cytokine production	3.75	0.00e+00	0.00e+00	61/275	ADAM8; C3AR1; C3; C5AR1; CARD11; CARD9; CASP1; CCDC88B; CCL3; CD14; CD226; CD28; CD40; CD4; CD74; CD80; CD83; CD86; CLEC4E; CLEC5A; CRTAM; CSF1R; CYBA; CYBB; EBI3; FCER1G; FGR; GPSM3; HAVCR2; HGF; HLA-DPA1; HLA-DPB1; HMOX1; HPSE; IL18; IL1A; IL1B; IRF5; IRF8; LGALS9; LILRA2; LILRB1; LY96; MMP8; NFAM1; NLRP3; OSM; P2RX7; PTAFR; PTGER4; PTPN22; PTPRC; SASH3; SLC11A1; SPN; TLR1; TLR2; TLR4; TLR6; TLR7; TLR8
GO:0038061	NIK/NF-kappaB signaling	3.70	1.62e-05	2.13e-04	14/64	ALK; CD14; HAVCR2; IL18; IL1B; LGALS9; MMP8; NLRP3; PTPN22; RASSF2; TLR2; TLR4; TLR6; TLR7
GO:0042113	B cell activation	3.64	1.40e-09	2.99e-08	28/130	BTK; CARD11; CD180; CD28; CD300A; CD40; CD74; DOCK10; FCGR2B; GAPT; GPR183; INPP5D; ITGA4; LAT2; LYL1; LYN; MFNG; MNDA; NCKAP1L; NFAM1; PIK3CD; POU2F2; PTPRC; SAMSN1; SASH3; SLAMF8; TLR4; TNFSF13B
GO:0002237	response to molecule of bacterial origin	3.64	1.33e-15	7.23e-14	48/223	ABCA1; ACP5; AXL; C5AR1; CARD16; CARD9; CASP1; CCL2; CCL3; CCR5; CD14; CD180; CD40; CD80; CD86; CSF2RB; CX3CR1; FCGR2B; HAMP; HAVCR2; HCK; IL10RA; IL18; IL1B; IRF5; IRF8; LGALS9; LILRA2; LILRB1; LY86; LY96; LYN; MRC1; NLRP3; P2RX7; PDCD1LG2; PTAFR; PTGER4; PTPN22; SIRPA; SLC11A1; SNCA; TLR1; TLR2; TLR4; TLR6; TNFRSF1B; TREM2
GO:0001818	negative regulation of cytokine production	3.64	2.93e-12	9.17e-11	37/172	ACP5; ADCY7; AXL; BTK; VSIR; CARD16; CD200R1; CD83; CD84; CLEC4A; CMKLR1; CX3CR1; FCGR2B; GPNMB; FFAR4; HAVCR2; HGF; HMOX1; INPP5D; LGALS9; LILRA4; LILRB1; MERTK; MMP8; NCKAP1L; NLRP3; PDCD1LG2; PTGER4; PTPN22; PTPRC; SIRPA; SLC11A1; SRGN; TLR4; TLR6; TLR8; VSIG4
GO:0010573	vascular endothelial growth factor production	3.62	5.11e-03	3.50e-02	6/28	C3AR1; C3; C5AR1; HPSE; IL1A; IL1B
GO:0007229	integrin-mediated signaling pathway	3.61	5.72e-06	7.75e-05	16/75	DAB2; FCER1G; FERMT3; FGR; FYB1; HCK; ITGA4; ITGAD; ITGAM; ITGAX; ITGB2; ITGB3; PLEK; PRAM1; TYROBP; VAV1
GO:2001057	reactive nitrogen species metabolic process	3.58	1.81e-04	1.89e-03	11/52	ACP5; AIF1; CX3CR1; GCHFR; IL1B; ITGB2; MMP8; SIRPA; TLR2; TLR4; TLR6
GO:1903706	regulation of hemopoiesis	3.45	1.13e-14	5.76e-13	48/235	ADAM8; AXL; BTK; VSIR; C1QC; CARD11; CCL3; CCR1; CD28; CD4; CD74; CD80; CD83; CD86; CR1; CSF1; CSF3R; EVI2B; FCGR2B; HCLS1; HLA-DOA; IL18; INPP5D; KAT2B; LGALS9; LILRB1; LILRB4; LYN; MAFB; MITF; NCKAP1L; NFAM1; NLRP3; PIK3R6; PTPRC; RASSF2; SASH3; SLAMF8; SLC46A2; SPI1; TGFBR2; TLR4; DCSTAMP; TMEM176A; TMEM176B; TYROBP; UBASH3B; VNN1
GO:0045088	regulation of innate immune response	3.44	9.19e-14	3.74e-12	45/221	ADAM8; APOE; BTK; CARD11; CARD9; CD14; CD1D; CD209; CD226; CD300A; CD300LF; CLEC4A; CLEC4E; CLEC7A; CR1; CRTAM; CTSS; CYBA; FCER1G; FCGR2B; FGR; HAVCR2; HCK; ITGAM; ITGB2; LGALS9; LILRA2; LILRA4; LILRB1; LY96; LYN; MARCO; MNDA; PIK3AP1; PIK3R6; PTPN22; SAMHD1; SLAMF8; TLR1; TLR2; TLR4; TLR6; TLR7; TLR8; VAV1
GO:0002440	production of molecular mediator of immune response	3.41	8.23e-08	1.46e-06	24/119	BTK; CARD11; CD226; CD28; CD40; CD74; FCER1G; FCGR2B; GAPT; HLA-DQB1; HMOX1; IL18; IL1B; LILRB1; NLRP3; POU2F2; PTPRC; SAMHD1; SASH3; SLC11A1; TLR2; TLR4; TNFRSF1B; TNFSF13B
GO:0071825	protein-lipid complex subunit organization	3.38	3.82e-03	2.70e-02	7/35	ABCA1; APOC1; APOC2; APOE; PLA2G7; PLTP; SOAT1
GO:0048010	vascular endothelial growth factor receptor signaling pathway	3.38	5.71e-04	5.28e-03	10/50	AXL; CYBA; CYBB; IL1B; ITGB3; NCF1; NCF2; NCF4; NCKAP1L; VAV1
GO:0050900	leukocyte migration	3.34	0.00e+00	0.00e+00	63/319	ADAM8; AIF1; JAML; C3AR1; C5AR1; CCL2; CCL3L1; CCL3L3; CCL3; CCL4L1; CCL8; CCR1; CCR5; CD200R1; CD300A; CD48; CD74; CD84; CMKLR1; CORO1A; CSF1; CSF3R; CX3CR1; CXCL16; DOCK8; DOK2; ADGRE2; FCER1G; FOLR2; FPR2; GPR183; GPSM3; GYPC; HCK; HMOX1; IL1B; INPP5D; ITGA4; ITGAM; ITGAX; ITGB2; ITGB3; LGALS9; LYN; MERTK; MYO1G; NCKAP1L; OLR1; P2RY12; PIK3CD; PIK3CG; PLA2G7; PTAFR; PTGER4; PTPRO; SELPLG; SIRPA; SLAMF8; SLC16A3; SLC7A7; SPN; TREM1; TRPM2; VAV1
GO:0030101	natural killer cell activation	3.31	1.26e-03	1.06e-02	9/46	AXL; CORO1A; HAVCR2; IL18; ITGB2; MERTK; PIK3CD; PTPN22; PTPRC
GO:0032103	positive regulation of response to external stimulus	3.29	6.21e-12	1.81e-10	41/211	ADAM8; AIF1; BTK; C3AR1; C3; C5AR1; CCL3L1; CCL3L3; CCL3; CCL4L1; CCR1; CD180; CD28; CD74; CEBPA; CMKLR1; CSF1; CYBA; FCER1G; FPR2; GPSM3; HAVCR2; IL18; IL1B; ITGAM; ITGB2; LGALS9; LY86; LY96; MMP8; NCKAP1L; OSM; P2RY12; PIK3CG; PLA2G7; PTGER4; SNCA; SUCNR1; TLR2; TLR4; TLR6; TLR7
GO:0030099	myeloid cell differentiation	3.25	1.61e-11	4.22e-10	40/208	C1QC; CCL3; CCR1; CD4; CD74; CEBPA; CLEC5A; CSF1R; CSF1; CSF3R; EVI2B; FCER1G; FLI1; GAB3; GPR183; HCLS1; IKZF1; INPP5D; IRF8; KAT2B; LGALS9; LILRB1; LILRB4; NRROS; LYN; MAFB; MITF; NCKAP1L; OSCAR; PDE1B; PIK3CD; RASSF2; SPI1; TGFBR2; TLR2; TLR4; DCSTAMP; TREM2; TYROBP; UBASH3B
GO:0022407	regulation of cell-cell adhesion	3.15	4.20e-14	1.90e-12	52/279	ADAM8; AIF1; VSIR; CARD11; CCDC88B; CCL2; CD1D; CD209; CD28; CD300A; CD4; CD74; CD80; CD83; CD86; CLECL1; CORO1A; DOCK8; EBI3; FCGR2B; FERMT3; GPNMB; HAVCR2; HLA-DMB; HLA-DPA1; HLA-DPB1; IL18; IL1B; ITGA4; LGALS9; LILRB1; LILRB4; LYN; NCKAP1L; NLRP3; PDCD1LG2; PIK3R6; PTAFR; PTPN22; PTPRC; RASAL3; SASH3; SIRPA; SIRPB1; SPN; TGFBR2; TNFAIP8L2; TNFSF13B; UBASH3B; VAV1; VNN1; VSIG4
GO:0097006	regulation of plasma lipoprotein particle levels	3.13	1.08e-03	9.22e-03	10/54	ABCA1; APOBR; APOC1; APOC2; APOE; HMOX1; MSR1; PLA2G7; PLTP; SOAT1
GO:0031349	positive regulation of defense response	3.13	5.67e-14	2.43e-12	52/281	ADAM8; BTK; C3; CARD11; CARD9; CCL3L1; CCL3L3; CCL3; CD14; CD1D; CD209; CD226; CD28; CD300A; CD300LF; CEBPA; CLEC4A; CLEC4E; CLEC7A; CRTAM; CTSS; CYBA; FCER1G; GPSM3; HAVCR2; HCK; IL18; IL1B; ITGAM; ITGB2; LGALS9; LILRA2; LILRA4; LY96; LYN; MARCO; MMP8; MNDA; OSM; PIK3AP1; PIK3CG; PLA2G7; PTGER4; PTPN22; SNCA; SUCNR1; TLR1; TLR2; TLR4; TLR6; TLR7; TLR8; VAV1
GO:0050727	regulation of inflammatory response	3.12	1.19e-12	4.05e-11	47/255	ACP5; ADAM8; ADCY7; APOE; BTK; C1QA; C1QB; C1QC; C2; C3AR1; C3; C5AR1; CCL3L1; CCL3L3; CCL3; CD200R1; CD28; CEBPA; CR1; FCER1G; FCGR2B; FFAR4; GPSM3; HCK; HGF; IL18; IL1B; ITGAM; ITGB2; LYN; MMP8; NLRP3; OSM; PIK3AP1; PIK3CG; PLA2G7; PTGER4; PTPRC; SIRPA; SLAMF8; SNCA; SUCNR1; TLR2; TLR4; TLR6; TLR7; TNFAIP8L2; TNFRSF1B
GO:0032602	chemokine production	3.10	6.70e-04	6.12e-03	11/60	CD74; CSF1R; HAVCR2; HMOX1; IL18; IL1B; LGALS9; SIRPA; TLR2; TLR4; TLR7
GO:0060326	cell chemotaxis	3.09	4.57e-11	1.09e-09	41/224	ADAM8; AIF1; JAML; BIN2; C3AR1; C5AR1; CCL2; CCL3L1; CCL3L3; CCL3; CCL4L1; CCL8; CCR1; CCR5; CCRL2; CD74; CMKLR1; CORO1A; CSF1; CSF3R; CX3CR1; CXCL16; DOCK4; ADGRE2; FCER1G; FOLR2; FPR2; GPR183; GPSM3; HGF; IL1B; ITGB2; LGALS9; LYN; NCKAP1L; PIK3CD; PIK3CG; PLA2G7; PTPRO; SLAMF8; TRPM2; VAV1
GO:0002697	regulation of immune effector process	3.08	5.69e-12	1.72e-10	45/247	BTK; C1QA; C1QB; C1QC; C2; C3AR1; C3; C5AR1; CD1D; CD226; CD28; CD300A; CD40; CD74; CD80; CD84; CD86; CR1; CRTAM; ADGRE2; FCER1G; FCGR2B; FGR; HAVCR2; HLA-DMB; HMOX1; IL18; IL1B; ITGAM; ITGB2; LGALS9; LILRB1; LYN; NLRP3; P2RX7; PIK3R6; PRAM1; PTAFR; PTPRC; SASH3; SLAMF8; TLR4; TNFRSF1B; VAV1; WAS
GO:0048872	homeostasis of number of cells	3.00	5.99e-07	9.02e-06	25/141	AXL; CARD11; CD74; CORO1A; CSF1; DOCK10; FCER1G; GAPT; GPR183; HCLS1; HMOX1; IKZF1; INPP5D; LGALS9; LYN; MAFB; MERTK; NCKAP1L; P2RX7; PIK3CD; RASSF2; SASH3; SLC46A2; SPI1; TNFSF13B
GO:0002526	acute inflammatory response	2.98	5.21e-06	7.19e-05	21/119	ADAM8; BTK; C1QA; C1QB; C1QC; C2; C3AR1; C3; C5AR1; CD163; CR1; FCER1G; FCGR2B; HAMP; IL1A; IL1B; NLRP3; OSM; PIK3CG; TREM1; VNN1
GO:0002683	negative regulation of immune system process	2.96	2.87e-12	9.17e-11	49/280	AXL; BTK; VSIR; C1QC; CCL2; CCL3; CD14; CD200R1; CD300A; CD300LF; CD74; CD80; CD84; CD86; CR1; FCER1G; FCGR2B; GPNMB; HAVCR2; HLA-DOA; HMOX1; INPP5D; LGALS9; LILRA2; LILRA4; LILRB1; LILRB4; LPXN; LST1; LY96; LYN; MAFB; MERTK; MNDA; PDCD1LG2; PTGER4; PTPN22; PTPRC; SAMHD1; SAMSN1; SLAMF8; SPN; TLR4; TLR6; TMEM176A; TMEM176B; TNFAIP8L2; UBASH3B; VSIG4
GO:0033627	cell adhesion mediated by integrin	2.93	3.08e-03	2.26e-02	9/52	FERMT3; ITGB2; ITGB3; LPXN; LYN; NCKAP1L; P2RY12; PIK3CG; PLAU
GO:0045785	positive regulation of cell adhesion	2.84	2.32e-11	5.72e-10	48/286	ADAM8; AIF1; APBB1IP; VSIR; CARD11; CASS4; CCDC88B; CCL2; CD1D; CD209; CD28; CD4; CD74; CD80; CD83; CD86; CLECL1; CORO1A; CSF1; DOCK8; EBI3; EMILIN2; HAVCR2; HLA-DMB; HLA-DPA1; HLA-DPB1; IL18; IL1B; ITGA4; LGALS9; LILRB1; LILRB4; LYN; NCKAP1L; NLRP3; P2RY12; PDCD1LG2; PIK3R6; PTAFR; PTPRC; RASAL3; SASH3; SIRPA; SIRPB1; TGFBR2; TNFSF13B; VAV1; VNN1
GO:0007249	I-kappaB kinase/NF-kappaB signaling	2.75	1.90e-05	2.42e-04	21/129	BTK; CARD11; CARD16; CARD9; CASP1; CD14; CD40; CD4; CD74; CX3CR1; HMOX1; IL1B; LGALS9; LY96; S100A4; SIRPA; TLR2; TLR4; TLR6; TLR7; TLR8
GO:0002831	regulation of response to biotic stimulus	2.74	1.96e-03	1.59e-02	11/68	CARD16; CD180; CD226; CRTAM; CYBA; HAVCR2; IL1B; LILRA2; LILRB1; LY86; LY96
GO:0031348	negative regulation of defense response	2.65	7.87e-05	8.66e-04	19/121	ACP5; ADCY7; APOE; CD200R1; CR1; FCGR2B; FFAR4; HAVCR2; HGF; LGALS9; LILRB1; NLRP3; PTGER4; PTPRC; SAMHD1; SIRPA; SLAMF8; TNFAIP8L2; TNFRSF1B
GO:0043491	protein kinase B signaling	2.51	3.60e-05	4.37e-04	23/155	ADAM8; AXL; CALCR; CCL2; CCL3; CD28; CD40; CD80; CD86; CX3CR1; HCLS1; HGF; HPSE; IL18; IL1B; MERTK; OSM; P2RY12; PIK3AP1; PIK3CD; PIK3CG; PIK3R5; VAV1
GO:0001906	cell killing	2.50	5.60e-04	5.24e-03	16/108	CD1D; CD226; CORO1A; CRTAM; CTSC; FCGR2B; HAMP; HAVCR2; IL18; LGALS9; LILRB1; LYZ; P2RX7; PIK3R6; PTPRC; VAV1
GO:0048017	inositol lipid-mediated signaling	2.50	5.60e-04	5.24e-03	16/108	CD28; CSF1R; FGR; HCLS1; HCST; HGF; IL18; LYN; NCF1; OSM; PIK3AP1; PIK3CD; PIK3CG; PIK3R5; PIK3R6; PTAFR
GO:0007200	phospholipase C-activating G protein-coupled receptor signaling pathway	2.50	2.68e-03	2.02e-02	12/81	C3AR1; C5AR1; CMKLR1; CX3CR1; FPR1; FPR2; FPR3; GNA15; GPR65; GRM1; P2RY12; P2RY6
GO:1990868	response to chemokine	2.50	2.68e-03	2.02e-02	12/81	CCL2; CCL3L1; CCL3L3; CCL3; CCL4L1; CCL8; CCR1; CCR5; CCRL2; CMKLR1; CX3CR1; DOCK8; TREM2
GO:0098542	defense response to other organism	2.47	1.51e-07	2.50e-06	38/260	ACP5; APOBEC3C; C5AR1; CARD9; CCDC88B; CD40; CD4; CLEC4E; CLEC7A; COTL1; CYBA; FCER1G; FGR; HAMP; HAVCR2; IL1B; IRF5; IRF8; LILRB1; LYZ; MPEG1; NLRP3; P2RX7; PTPRC; RNASE1; RNASE2; RNASE6; SAMHD1; SLAMF8; SLC11A1; SPN; STAB1; TLR2; TLR4; TLR6; TLR7; TLR8; TNFSF8
GO:0048771	tissue remodeling	2.46	6.88e-04	6.23e-03	16/110	ACP5; ADAM8; AXL; CSF1R; GPNMB; IL18; IL1A; INPP5D; ITGB3; MERTK; MITF; P2RX7; RASSF2; SPP1; DCSTAMP; UBASH3B
GO:0072593	reactive oxygen species metabolic process	2.45	5.43e-05	6.13e-04	23/159	ACP5; AIF1; CX3CR1; CYBA; CYBB; FPR2; GCHFR; IL1B; ITGAM; ITGB2; NRROS; MMP8; NCF1; NCF2; NCF4; P2RX7; SIRPA; SNCA; TGFBR2; TLR2; TLR4; TLR6; VAV1
GO:0006959	humoral immune response	2.36	4.71e-05	5.48e-04	25/179	C1QA; C1QB; C1QC; C2; C3AR1; C3; C5AR1; CCL2; CD28; CD83; CR1; EBI3; FCGR2B; GPR183; HLA-DQB1; LY86; LYZ; POU2F2; PTPRC; RNASE2; RNASE6; SLC11A1; TREM1; TREM2; VSIG4
GO:0006898	receptor-mediated endocytosis	2.35	3.60e-05	4.37e-04	26/187	APOBR; APOC1; APOC2; APOE; ASGR1; ASGR2; CD14; CD163; CXCL16; DAB2; FCER1G; FCGR1A; FCGR1B; FCGR2B; FOLR2; FPR2; ITGA4; ITGB2; ITGB3; LILRB1; MARCO; MRC1; MSR1; SNCA; STAB1; TGFBR2
GO:0060627	regulation of vesicle-mediated transport	2.29	7.80e-07	1.11e-05	39/288	APOC1; APOC2; APOE; AXL; C2; C3; CCL2; CD14; CD300A; CD300LF; CD84; CHRNA6; CORO1A; CYBA; DAB2; DOCK2; ADGRE2; FCER1G; FCGR2B; FGR; HCK; HMOX1; IL1B; ITGAM; ITGB2; ITGB3; LGALS9; LILRB1; LYN; MERTK; NCKAP1L; PRAM1; PTAFR; PTPRC; SIRPA; SIRPB1; SLC11A1; SNCA; TLR2
GO:0070555	response to interleukin-1	2.29	4.06e-03	2.85e-02	13/96	CCL2; CCL3L1; CCL3L3; CCL3; CCL4L1; CCL8; CD40; CYBA; IL1A; IL1B; LGALS9; SIRPA; SNCA; ST18
GO:0050920	regulation of chemotaxis	2.28	3.18e-04	3.19e-03	21/156	AIF1; C3AR1; C5AR1; CCL2; CCL3; CCL4L1; CCR1; CD74; CMKLR1; CSF1; FPR2; GPR183; GPSM3; LGALS9; LYN; NCKAP1L; P2RY12; PLA2G7; PTPRO; SLAMF8; SUCNR1
GO:0050817	coagulation	2.27	6.81e-05	7.59e-04	26/194	APOE; AXL; CD40; DOCK8; FCER1G; FERMT3; GNA15; HPSE; ITGB3; LCP2; LYN; MERTK; P2RX7; P2RY12; PIK3CD; PIK3CG; PIK3R5; PIK3R6; PLAUR; PLAU; PLEK; TLR4; TREML1; UBASH3B; VAV1; WAS
GO:0070371	ERK1 and ERK2 cascade	2.25	1.20e-05	1.60e-04	32/241	ALK; APOE; AXL; C5AR1; CALCR; CCL2; CCL3L1; CCL3L3; CCL3; CCL4L1; CCL8; CCR1; CD4; CD74; CSF1R; EPHB2; FPR2; GPNMB; FFAR4; GPR183; HAVCR2; IL1B; LGALS9; LYN; MARCO; MERTK; P2RY6; PTGER4; PTPN22; PTPRC; SIRPA; TLR4; TREM2
GO:2000147	positive regulation of cell motility	2.18	7.78e-07	1.11e-05	43/333	ADAM8; AIF1; VSIR; C3AR1; C5AR1; CASS4; CCL3; CCL4L1; CCL8; CCR1; CD40; CD74; CMKLR1; CORO1A; CSF1R; CSF1; CXCL16; DAB2; DOCK4; DOCK8; FERMT3; FGR; FPR2; GPNMB; GPSM3; HGF; HMOX1; IL1B; ITGA4; ITGB3; LGALS9; LYN; NCKAP1L; P2RY12; P2RY6; PIK3CD; PLA2G7; PLAU; PTAFR; PTPRC; SLC8A1; SPN; TGFBR2
GO:0034612	response to tumor necrosis factor	2.14	9.73e-04	8.43e-03	20/158	CARD16; CASP1; CCL2; CCL3L1; CCL3L3; CCL3; CCL4L1; CCL8; CD14; CD40; CEBPA; CRHBP; CXCL16; CYBA; GSDME; HAMP; ST18; DCSTAMP; TNFRSF1B; TNFSF13B; TNFSF8
GO:0007162	negative regulation of cell adhesion	2.14	5.60e-04	5.24e-03	22/174	ADAMDEC1; VSIR; CD300A; CD74; CD80; CD86; FCGR2B; GPNMB; HAVCR2; LGALS9; LILRB1; LPXN; PDCD1LG2; PLXNC1; PTPN22; PTPRC; PTPRO; SPN; TGFBI; TNFAIP8L2; UBASH3B; VSIG4
GO:0051701	interaction with host	2.13	7.41e-03	4.86e-02	13/103	AXL; CCR5; CD209; CD4; CD74; CD80; CD86; CLEC5A; CR1; ITGB3; LGALS9; MRC1; SELPLG
GO:0019058	viral life cycle	2.13	2.42e-03	1.88e-02	17/135	APOBEC3C; APOE; AXL; CCL2; CCR5; CD209; CD28; CD4; CD74; CD80; CD86; CLEC5A; CR1; ITGB3; LGALS9; MRC1; SELPLG
GO:0051235	maintenance of location	2.11	3.77e-04	3.70e-03	24/192	ABCA1; APOE; C3; CCL3; CCR5; CD4; CORO1A; CYBA; FTL; IL1B; ITGB3; NRROS; LYN; MSR1; P2RX7; P2RY6; PLIN2; PTPRC; SLC8A1; SNCA; SOAT1; SRGN; TRPM2; UBASH3B

Factor 7 : 4 significant GO terms

GeneSet	description	enrichRatio	pValue	FDR	GeneRatio	geneSymbols
GO:0006575	cellular modified amino acid metabolic process	2.27	1.64e-05	0.0134	29/121	ACADL; ALDH4A1; ASS1; CRAT; CRYM; EGLN3; ERO1A; G6PD; GGCT; GGT1; GGT6; GGTLC1; GGTLC2; GNMT; GSR; GSTZ1; IDH1; IYD; MBOAT1; MTHFD2; MTHFR; P4HA1; CPQ; PLA2G2A; PRODH; PTGES; SERINC2; VNN2; VNN3
GO:0007586	digestion	2.17	2.35e-04	0.0382	23/100	ADM2; AKR1D1; AQP5; INAVA; CLPSL2; CLPSL1; CCKBR; CHIA; CHRM1; LCT; MOGAT2; MUC6; OPRL1; PGC; PPARGC1A; PRSS1; PTGER3; SCARB1; SERPINA3; SLC26A6; SLC26A7; SLC5A1; SNX10
GO:0042180	cellular ketone metabolic process	2.10	3.01e-04	0.0409	24/108	ACADL; ADIPOR2; ADM; AKR1B10; C1QTNF2; CBR3; COMT; FABP5; FGFR4; GSTZ1; IRS1; KMO; KYNU; NQO1; OAZ3; PDK1; PDP1; PLIN5; PPARGC1A; SRD5A1; STARD3; TRIB3; UGT1A8; WNT4
GO:0006520	cellular amino acid metabolic process	2.03	3.66e-05	0.0149	34/158	ADSSL1; ALDH4A1; ASRGL1; ASS1; BCAT2; COMT; CRYM; DDC; EGLN3; ERO1A; FAH; GGT1; GLYATL1; GNMT; GSTZ1; HGD; HMGCLL1; HPD; IYD; KMO; KYNU; MTHFR; NAGS; NAT8L; NMNAT3; NQO1; OAT; OAZ3; P4HA1; PAH; PHGDH; PRODH; PSPH; TST

Factor 8 : 27 significant GO terms

GeneSet	description	enrichRatio	pValue	FDR	GeneRatio	geneSymbols
GO:0140029	exocytic process	5.29	1.32e-05	9.14e-04	10/47	CPLX2; KCNB1; NAPB; PPFIA3; RAB3A; RAB3C; SNAP25; STX1A; STXBP1; UNC13A
GO:0099504	synaptic vesicle cycle	4.85	7.42e-11	6.04e-08	24/123	BRSK2; BSN; CACNB2; CDK5R1; CHRNB2; CPLX2; DDC; DNAJC6; DRD2; NAPB; NRXN1; PPFIA3; RAB3A; RIMS2; SNAP25; SNCB; STX1A; STXBP1; SYN1; SYP; SYT13; SYT4; SYT5; UNC13A
GO:0017156	calcium ion regulated exocytosis	4.82	3.28e-09	1.01e-06	20/103	CACNB2; CDK5R2; CHRNB2; CPLX2; DRD2; KCNB1; NAPB; PPFIA3; RAB3A; RIMS2; SCAMP5; SNAP25; STX1A; STXBP1; SYN1; SYP; SYT13; SYT4; SYT5; UNC13A
GO:0048284	organelle fusion	4.52	3.13e-04	1.16e-02	8/44	CPLX2; GDAP1; RAB39A; RAB3A; SNAP25; STX1A; STXBP1; SYT4
GO:0099003	vesicle-mediated transport in synapse	4.46	5.85e-09	1.01e-06	21/117	AP3B2; CACNB2; CHRNB2; CPLX2; DNAJC6; DRD2; KIF5A; NAPB; PPFIA3; RAB3A; RIMS2; SNAP25; SNCB; STX1A; STXBP1; SYN1; SYP; SYT13; SYT4; SYT5; UNC13A
GO:0099565	chemical synaptic transmission, postsynaptic	4.40	2.52e-06	2.05e-04	14/79	CELF4; CHRNA3; CHRNB2; DRD2; GRIK2; GRIN2C; IGSF9B; MAPK8IP2; MPP2; NRXN1; P2RX6; RIMS2; SEZ6; STX1A
GO:0035418	protein localization to synapse	4.35	9.46e-04	3.08e-02	7/40	BSN; GRIN2C; IQSEC2; KIF5A; NRXN1; ARHGAP44; SNAP25
GO:0022406	membrane docking	4.30	1.96e-04	8.87e-03	9/52	CPLX2; KCNB1; PPFIA3; RAB3A; RAB3C; SNAP25; STX1A; STXBP1; UNC13A
GO:0015837	amine transport	4.09	1.35e-05	9.14e-04	13/79	CARTPT; CHGA; CHRNA3; CHRNB2; DDC; DRD2; HRH3; KCNB1; STX1A; STXBP1; SYT13; SYT4; SYT5
GO:0015844	monoamine transport	3.71	3.10e-04	1.16e-02	10/67	CARTPT; CHGA; CHRNB2; DRD2; HRH3; KCNB1; STX1A; SYT13; SYT4; SYT5
GO:0051648	vesicle localization	3.57	3.15e-07	3.21e-05	21/146	AP3B2; BRSK2; CACNB2; CHRNB2; CPLX2; DRD2; GRIA1; KIF5A; NAPB; PPFIA3; RAB3A; RIMS2; SNAP25; STX1A; STXBP1; SYN1; SYP; SYT13; SYT4; SYT5; UNC13A
GO:0006836	neurotransmitter transport	3.57	6.23e-09	1.01e-06	27/188	ASIC1; CACNB2; CHRNA3; CHRNB2; CPLX2; DDC; DRD2; GRM4; HRH3; NAPB; NRXN1; PPFIA3; PTPRN2; RAB3A; RIMS2; SLC1A2; SLC6A12; SLC6A17; SNAP25; STX1A; STXBP1; SYN1; SYP; SYT13; SYT4; SYT5; UNC13A
GO:0030534	adult behavior	3.47	7.98e-05	3.82e-03	13/93	CARTPT; CHRNA3; CHRNB2; DRD2; FGF12; GABRG2; UNC79; NRXN1; SEZ6L; SEZ6; SLC1A2; SLITRK1; SPTBN4
GO:0098739	import across plasma membrane	3.15	1.17e-03	3.68e-02	10/79	ATP1A3; FAM155B; HCN2; HCN4; HFE; KCNH2; KCNJ6; SLC12A5; SLC1A2; SLC36A4
GO:0099177	regulation of trans-synaptic signaling	3.00	3.75e-09	1.01e-06	35/290	ASIC1; ACHE; CACNB2; CAMK2B; CELF4; CHRNA3; CHRNB2; CPLX2; DGKE; DRD2; GRIA1; GRIK2; GRIN2C; GRM4; IGSF9B; IQSEC2; JPH3; KCNB1; MAPK8IP2; MPP2; NAPB; NPTXR; NRXN1; PPFIA3; RAB3A; RIMS2; SCGN; SLC8A2; SNAP25; STX1A; STXBP1; SYN1; SYP; SYT4; UNC13A
GO:0001764	neuron migration	2.95	6.95e-04	2.46e-02	12/101	ASCL1; CAMK2B; CDK5R1; CDK5R2; CELSR3; DRD2; FGFR1; GPR173; KIAA0319; NAV1; NEUROD4; SCRT1
GO:1990778	protein localization to cell periphery	2.91	2.46e-05	1.54e-03	19/162	ANK1; ANK3; CACNB2; GRIN2C; IQSEC2; KCNB1; KCNIP3; LGALS3; NFASC; PIK3R1; RAB3A; RAB3C; ARHGAP44; SCN3B; SNAP25; SPTBN4; STXBP1; TUB; ZDHHC22
GO:0042391	regulation of membrane potential	2.88	1.75e-08	2.38e-06	34/293	ASIC1; ANK3; ATP1A3; CACNB2; CELF4; CHRNA3; CHRNB2; DRD2; FGF12; GABRG2; GRIA1; GRIK2; GRIN2C; HCN2; HCN3; HCN4; IGSF9B; KCNB1; KCNC1; KCNH2; KCNH3; KCNH4; KCNH6; KCNU1; MAPK8IP2; MPP2; NRXN1; NTSR2; P2RX6; RIMS2; SCN3B; SEZ6; SLC26A10; STX1A
GO:0001505	regulation of neurotransmitter levels	2.80	1.06e-06	9.58e-05	27/240	ASIC1; ACHE; CACNB2; CHRNA3; CHRNB2; CPLX2; DDC; DRD2; GRM4; HRH3; NAPB; NRXN1; PAH; PPFIA3; PTPRN2; RAB3A; RIMS2; SLC1A2; SNAP25; STX1A; STXBP1; SYN1; SYP; SYT13; SYT4; SYT5; UNC13A
GO:0006813	potassium ion transport	2.78	3.07e-05	1.78e-03	20/179	ANK3; ATP1A3; DRD2; HCN2; HCN3; HCN4; KCNB1; KCNC1; KCNH2; KCNH3; KCNH4; KCNH6; KCNIP3; KCNJ6; KCNK3; KCNQ2; KCNU1; SLC12A5; SLC24A5; SNAP25
GO:0023061	signal release	2.66	1.35e-07	1.57e-05	34/318	ASIC1; BRSK2; CACNB2; CARTPT; CHGA; CHRNA3; CHRNB2; CPLX2; DRD2; FGFR1; GRM4; HFE; HRH3; IRS2; KCNB1; NAPB; NRXN1; PPFIA3; PTPRN2; RAB3A; RIMS2; SCG5; SMPD3; SNAP25; STX1A; STXBP1; SYN1; SYP; SYT13; SYT4; SYT5; TCF7L2; UNC13A; VGF
GO:0032386	regulation of intracellular transport	2.64	4.26e-05	2.31e-03	21/198	ABCA2; ANK3; BRSK2; CACNB2; CDK5R1; CHRNB2; CPLX2; DRD2; KCNB1; NAPB; PIK3R1; RAB3A; REEP2; ARHGAP44; RIMS2; STX1A; STXBP1; SYN1; SYP; SYT4; TCF7L2
GO:0016358	dendrite development	2.61	1.38e-03	4.16e-02	13/124	CAMK2B; CDK5R1; CHRNA3; CHRNB2; CTNNA2; EFNA1; KIAA0319; MAP6; MAPK8IP2; ARHGAP44; SARM1; SEZ6; SLC12A5
GO:0051656	establishment of organelle localization	2.33	2.51e-04	1.02e-02	21/224	AP3B2; CACNB2; CHGA; CHRNB2; CPLX2; DRD2; GRIA1; KIF5A; NAPB; PPFIA3; RAB3A; RIMS2; SNAP25; STX1A; STXBP1; SYN1; SYP; SYT13; SYT4; SYT5; UNC13A
GO:0050808	synapse organization	2.28	6.47e-05	3.29e-03	26/283	ACHE; ANK3; BSN; C1QL1; CACNB2; CAMK2B; CDK5R1; CHRNB2; CTNNA2; DLGAP3; DRD2; EFNA1; IGSF9B; L1CAM; LRTM2; NFASC; NRXN1; RAB39B; RAB3A; ARHGAP44; SEZ6L; SEZ6; SLITRK1; SNCB; SYN1; UNC13A
GO:0021700	developmental maturation	2.25	1.44e-03	4.20e-02	17/188	ASCL1; C1QL1; CAMK2B; CDK5R1; CDK5R2; CDKN1A; FGFR1; NFASC; NRXN1; RAB3A; SEZ6L; SEZ6; SPTBN4; STXBP1; SYP; SYT4; UNC13A
GO:0060627	regulation of vesicle-mediated transport	2.16	2.21e-04	9.47e-03	25/288	CACNB2; CDK5R2; CHRNB2; CPLX2; DNAJC6; DRD2; HFE; KCNB1; LGALS3; NAPB; PACSIN3; RAB3A; RAB3C; ARHGAP44; RIMS2; SCAMP5; SMPD3; STX1A; STXBP1; SYN1; SYP; SYT4; SYT5; TUB; VTN

Factor 9 : 11 significant GO terms

GeneSet	description	enrichRatio	pValue	FDR	GeneRatio	geneSymbols
GO:0140053	mitochondrial gene expression	10.50	1.14e-05	1.86e-03	6/16	CHCHD10; MRPL21; MRPL23; MRPL41; MRPS21; NDUFA7
GO:0070972	protein localization to endoplasmic reticulum	10.30	2.85e-09	1.16e-06	11/30	RPL13; RPL18; RPL28; RPL35; RPLP2; RPS16; RPS19; RPS21; RPS26; RPS28; SEC61G
GO:0010257	NADH dehydrogenase complex assembly	10.20	4.26e-04	3.15e-02	4/11	NDUFAF8; NDUFA3; NDUFA7; NDUFS5
GO:0006413	translational initiation	9.36	1.90e-09	1.16e-06	12/36	AGO2; RPL13; RPL18; RPL28; RPL35; RPLP2; RPS16; RPS19; RPS21; RPS26; RPS28; UHMK1
GO:0000726	non-recombinational repair	8.26	2.40e-04	2.17e-02	5/17	BARD1; PRKDC; RIF1; RNF168; USP51
GO:0006414	translational elongation	8.26	2.40e-04	2.17e-02	5/17	MRPL21; MRPL23; MRPL41; MRPS21; RPLP2
GO:0006401	RNA catabolic process	4.40	6.28e-06	1.28e-03	13/83	AGO2; ERN1; HELZ2; RPL13; RPL18; RPL28; RPL35; RPLP2; RPS16; RPS19; RPS21; RPS26; RPS28
GO:0070646	protein modification by small protein removal	4.14	2.75e-04	2.24e-02	9/61	ASXL2; BARD1; CLSPN; MINDY2; MYSM1; PSMB3; PSME2; USP12; USP51
GO:0006302	double-strand break repair	3.95	1.88e-04	2.17e-02	10/71	BARD1; BRCA2; EME2; EYA3; HELB; PRKDC; RIF1; RNF168; SAMHD1; USP51
GO:0090150	establishment of protein localization to membrane	3.94	5.04e-06	1.28e-03	15/107	SYNE3; KIAA0754; KIF13A; MACF1; ROMO1; RPL13; RPL18; RPL28; RPL35; RPLP2; RPS16; RPS19; RPS21; RPS26; RPS28; ZDHHC20
GO:0006605	protein targeting	3.40	3.09e-05	4.20e-03	15/124	LEPROT; ROMO1; RPL13; RPL18; RPL28; RPL35; RPLP2; RPS16; RPS19; RPS21; RPS26; RPS28; SEC61G; VPS13C; ZDHHC20

Factor 11 : 13 significant GO terms

GeneSet	description	enrichRatio	pValue	FDR	GeneRatio	geneSymbols
GO:0018149	peptide cross-linking	17.70	1.14e-11	3.09e-09	11/38	IVL; PI3; SPRR1A; SPRR1B; SPRR2A; SPRR2B; SPRR2D; SPRR2E; SPRR2F; SPRR3; SPRR4
GO:0042440	pigment metabolic process	9.94	2.56e-05	2.60e-03	6/37	UGT1A10; UGT1A1; UGT1A4; UGT1A7; UGT1A8; UGT1A9
GO:0009620	response to fungus	9.43	7.63e-04	4.78e-02	4/26	C10orf99; S100A12; S100A8; S100A9
GO:0043588	skin development	7.88	0.00e+00	0.00e+00	31/241	CASP14; EPHA2; GJB3; IVL; KRT13; KRT16; KRT3; KRT5; KRT6A; KRT6B; KRT6C; KRT78; CERS3; PI3; RPTN; S100A7; SCEL; SERPINB13; SNAI1; SOX21; SPRR1A; SPRR1B; SPRR2A; SPRR2B; SPRR2D; SPRR2E; SPRR2F; SPRR2G; SPRR3; SPRR4; TP63
GO:0008544	epidermis development	7.18	0.00e+00	0.00e+00	32/273	BNC1; CASP14; EPHA2; IVL; KRT13; KRT16; KRT3; KRT5; KRT6A; KRT6B; KRT6C; KRT78; KRTDAP; CERS3; PI3; RPTN; S100A7; SCEL; SERPINB13; SNAI1; SOX21; SPRR1A; SPRR1B; SPRR2A; SPRR2B; SPRR2D; SPRR2E; SPRR2F; SPRR2G; SPRR3; SPRR4; TP63
GO:0032602	chemokine production	6.13	4.06e-04	2.75e-02	6/60	CXCL6; EPHA2; IL4R; LBP; S100A8; S100A9
GO:0006720	isoprenoid metabolic process	5.84	6.15e-05	5.57e-03	8/84	ADH7; AKR1B10; CYP2C19; UGT1A1; UGT1A3; UGT1A7; UGT1A8; UGT1A9
GO:0035821	modification of morphology or physiology of other organism	5.65	2.22e-04	1.65e-02	7/76	CXCL6; DEFB4A; KRT6A; PGLYRP3; PGLYRP4; S100A12; S100A9
GO:0006959	humoral immune response	4.45	6.14e-06	7.15e-04	13/179	CXCL1; CXCL6; DEFB1; DEFB4A; CXCL8; KRT6A; PGLYRP3; PGLYRP4; PI3; S100A12; S100A7; S100A8; S100A9
GO:0009410	response to xenobiotic stimulus	4.33	3.61e-06	4.90e-04	14/198	ALDH3A1; CYP2C18; CYP2C19; GJB2; S100A12; UGT1A10; UGT1A1; UGT1A3; UGT1A4; UGT1A5; UGT1A6; UGT1A7; UGT1A8; UGT1A9
GO:0060326	cell chemotaxis	4.10	3.12e-06	4.90e-04	15/224	C10orf99; CCL20; CXCL1; CXCL6; DEFB4A; EPHA2; HBEGF; IL36G; IL1RN; CXCL8; LBP; S100A12; S100A7; S100A8; S100A9
GO:0098542	defense response to other organism	4.01	9.01e-07	1.83e-04	17/260	C10orf99; CCL20; CXCL6; DEFB1; DEFB4A; EPHA2; GBP6; IL4R; KRT6A; LBP; MMP12; PGLYRP3; PGLYRP4; S100A12; S100A7; S100A8; S100A9
GO:0005996	monosaccharide metabolic process	4.01	1.85e-04	1.51e-02	10/153	SLC2A1; UGT1A10; UGT1A1; UGT1A3; UGT1A4; UGT1A5; UGT1A6; UGT1A7; UGT1A8; UGT1A9

Factor 13 : 67 significant GO terms

GeneSet	description	enrichRatio	pValue	FDR	GeneRatio	geneSymbols
GO:0051383	kinetochore organization	26.70	1.84e-14	6.25e-13	10/11	CDT1; CENPA; CENPE; CENPF; CENPK; CENPN; CENPW; NDC80; NUF2; SMC4
GO:0061641	CENP-A containing chromatin organization	22.60	4.51e-13	1.31e-11	10/13	KNL1; CENPA; CENPI; CENPK; CENPM; CENPN; CENPW; HJURP; CENPU; OIP5
GO:0034502	protein localization to chromosome	20.10	0.00e+00	0.00e+00	15/22	AURKB; BRCA2; BUB1B; KNL1; CDCA5; CDK1; CDT1; CENPA; ESCO2; EZH2; HASPIN; MTBP; NDC80; PLK1; TTK
GO:0036297	interstrand cross-link repair	19.60	7.02e-10	1.54e-08	8/12	EME1; FANCA; FANCB; FANCE; FANCI; RAD51AP1; RAD51; UBE2T
GO:0050000	chromosome localization	18.50	0.00e+00	0.00e+00	17/27	CCNB1; CDCA5; CDCA8; CDT1; CENPE; CENPF; CEP55; DLGAP5; FAM83D; KIF14; KIF18A; KIF2C; KIFC1; NDC80; NUF2; PSRC1; SPAG5
GO:0006260	DNA replication	17.20	0.00e+00	0.00e+00	56/96	ATAD5; BARD1; BLM; BRCA1; BRCA2; BRIP1; TICRR; RMI2; CCNA2; CCNE1; CCNE2; CDC45; CDC6; CDC7; CDK1; CDT1; CHAF1B; CHEK1; CHTF18; CLSPN; DBF4; DDX11; DNA2; DSCC1; DTL; E2F7; E2F8; EME1; ESCO2; EXO1; FBXO5; FEN1; GINS1; GINS2; GINS4; GMNN; PCLAF; MCM10; MCM2; MCM4; MCM5; MCM6; MCM7; TONSL; ORC1; PIF1; POLD1; POLE2; POLQ; RAD51; RECQL4; RFC4; RNASEH2A; RRM2; ALYREF; WDHD1
GO:0007059	chromosome segregation	16.90	0.00e+00	0.00e+00	72/125	AURKB; BIRC5; BLM; BRCA1; BRIP1; BUB1B; BUB1; KNSTRN; RMI2; KNL1; CCNB1; CCNE1; CCNE2; CDC20; CDC6; CDCA5; CDCA8; CDT1; CENPE; CENPF; CENPN; CENPW; CEP55; DDX11; DLGAP5; DSCC1; ECT2; EME1; ESCO2; ESPL1; FAM83D; FBXO5; FEN1; HASPIN; HJURP; KIF14; KIF18A; KIF18B; KIF23; KIF2C; KIF4A; KIFC1; MAD2L1; MKI67; NCAPD2; NCAPG; NCAPH; NDC80; NEK2; NUF2; NUSAP1; OIP5; PLK1; PRC1; PSRC1; PTTG1; RACGAP1; RAD51C; SGO1; SGO2; SKA1; SKA2; SKA3; SMC4; SPAG5; SYCE2; TACC3; NDC1; TOP2A; TRIP13; TTK; ZWINT
GO:1902850	microtubule cytoskeleton organization involved in mitosis	16.10	0.00e+00	0.00e+00	29/53	AURKA; AURKB; SAPCD2; CCNB1; CDC20; CENPA; CENPE; ESPL1; GPSM2; KIF11; KIF23; KIF4A; KIFC1; MYBL2; NDC80; NEK2; NUF2; NUSAP1; PLK1; POC1A; PRC1; PSRC1; RACGAP1; STIL; STMN1; TACC3; TPX2; TTK; WDR62
GO:0045023	G0 to G1 transition	15.80	6.95e-08	1.41e-06	7/13	BRCA1; CDC7; CHEK1; E2F1; EZH2; RAD51; RRM2
GO:0006301	postreplication repair	14.70	1.13e-06	2.05e-05	6/12	BRCA1; DTL; PCLAF; POLD1; POLE2; RFC4
GO:0000075	cell cycle checkpoint	14.50	0.00e+00	0.00e+00	36/73	AURKA; AURKB; BLM; BRCA1; BRIP1; BUB1B; BUB1; TICRR; CCNB1; CDC20; CDC25C; CDC45; CDC6; CDK1; CDT1; CENPF; CHEK1; CLSPN; DNA2; DTL; E2F1; E2F7; E2F8; EME1; GTSE1; H2AFX; KNTC1; MAD2L1; NDC80; ORC1; PLK1; TOP2A; TRIP13; TTK; WDR76; ZWINT
GO:0007051	spindle organization	13.80	0.00e+00	0.00e+00	31/66	ASPM; AURKA; AURKB; KNSTRN; AUNIP; CCNB1; CDC20; CENPE; ESPL1; FBXO5; GPSM2; KIF11; KIF23; KIF4A; KIFC1; MYBL2; NDC80; NEK2; NUF2; PLK1; POC1A; PRC1; PSRC1; RACGAP1; SPAG5; STIL; STMN1; TACC3; TPX2; TTK; WDR62
GO:0032200	telomere organization	13.80	2.09e-14	6.80e-13	15/32	AURKB; BLM; BRCA2; CCNE1; CCNE2; DNA2; EXO1; FEN1; NEK2; PIF1; POLD1; RAD51C; RAD51; RECQL4; RFC4
GO:0006302	double-strand break repair	13.70	0.00e+00	0.00e+00	33/71	BARD1; BLM; BRCA1; BRCA2; BRIP1; PARPBP; RMI2; AUNIP; CDC45; CDC7; CDCA5; CHEK1; DDX11; DEK; DNA2; EME1; ESCO2; EXO1; FANCB; FEN1; FOXM1; GINS2; GINS4; H2AFX; TONSL; POLQ; RAD51AP1; RAD51C; RAD51; RAD54B; RAD54L; RECQL4; TRIP13
GO:0051653	spindle localization	12.90	4.24e-07	8.03e-06	7/16	ASPM; SAPCD2; CENPA; ESPL1; GPSM2; NDC80; NUSAP1
GO:0071103	DNA conformation change	12.60	0.00e+00	0.00e+00	42/98	ASF1B; BLM; BRIP1; KNL1; CCNB1; CDC45; CDCA5; CDK1; CENPA; CENPI; CENPK; CENPM; CENPN; CENPW; CHAF1B; DDX11; DNA2; GINS1; GINS2; GINS4; H2AFX; HELLS; HJURP; HMGB2; MCM2; MCM4; MCM6; MCM7; CENPU; NCAPD2; NCAPG2; NCAPG; NCAPH; NUSAP1; OIP5; PIF1; RAD51; RAD54B; RAD54L; RECQL4; SMC4; TOP2A
GO:0006284	base-excision repair	12.60	3.47e-06	5.88e-05	6/14	DNA2; FEN1; NEIL3; POLD1; POLQ; RECQL4
GO:0000910	cytokinesis	12.50	0.00e+00	0.00e+00	25/59	ANLN; AURKA; AURKB; BRCA2; CDC25B; CDC6; CDT1; CENPA; CEP55; CIT; CKAP2; E2F7; E2F8; ECT2; ESPL1; KIF14; KIF20A; KIF23; KIF4A; NUSAP1; PLK1; PRC1; RACGAP1; SEPT3; STMN1
GO:0044839	cell cycle G2/M phase transition	12.40	0.00e+00	0.00e+00	35/83	ATAD5; AURKA; AURKB; BLM; BRCA1; TICRR; CCNA2; CCNB1; CCNB2; CDC25A; CDC25B; CDC25C; CDC6; CDC7; CDK1; CENPF; CHEK1; CIT; CLSPN; DTL; FBXO5; FOXM1; GTSE1; HMMR; KIF14; MELK; NEK2; ORC1; PKMYT1; PLK1; PLK4; RAD51C; RECQL4; SKP2; TPX2
GO:0000726	non-recombinational repair	12.10	7.01e-07	1.30e-05	7/17	BARD1; BLM; BRCA1; AUNIP; DEK; H2AFX; POLQ
GO:0044772	mitotic cell cycle phase transition	11.80	0.00e+00	0.00e+00	77/192	ANLN; ATAD5; AURKA; AURKB; BLM; BRCA1; BUB1B; BUB1; TICRR; CCNA2; CCNB1; CCNB2; CCNE1; CCNE2; CDC20; CDC25A; CDC25B; CDC25C; CDC45; CDC6; CDC7; CDCA5; CDK1; CDKN2C; CDKN2D; CDKN3; CDT1; CENPE; CENPF; CIT; CKS1B; CKS2; CLSPN; DBF4; DLGAP5; DTL; E2F1; E2F7; E2F8; ESPL1; EZH2; FBXO5; FOXM1; GMNN; GTSE1; HMMR; IQGAP3; KIF14; KNTC1; MAD2L1; MCM10; MCM2; MCM4; MCM5; MCM6; MCM7; MELK; MTBP; NDC80; NEK2; ORC1; PKMYT1; PLK1; PLK4; POLE2; RAD51C; RBL1; RECQL4; RRM2; SKP2; TACC3; TPX2; TRIP13; TTK; TYMS; UBE2C; UBE2S
GO:0048285	organelle fission	11.00	0.00e+00	0.00e+00	81/216	ANLN; ASPM; AURKA; AURKB; BLM; BRCA2; BRIP1; BUB1B; BUB1; KNSTRN; CCNA2; CCNB1; CCNB2; CCNE1; CCNE2; CCNF; CDC20; CDC25B; CDC25C; CDC6; CDCA5; CDCA8; CDT1; CENPE; CENPF; CEP55; CHEK1; CKS2; DLGAP5; DSCC1; EME1; ESPL1; MTFR2; FANCA; FBXO5; HASPIN; KIF11; KIF14; KIF18A; KIF18B; KIF23; KIF2C; KIF4A; KIFC1; KNTC1; MAD2L1; MKI67; MND1; MTBP; MYBL1; MYBL2; NCAPD2; NCAPG; NCAPH; NDC80; NEK2; NUF2; NUSAP1; PKMYT1; PLK1; PRC1; PSRC1; PTTG1; RACGAP1; RAD51C; RAD51; RAD54B; SGO1; SGO2; SMC4; SPAG5; SYCE2; TACC3; NDC1; TOP2A; TPX2; TRIP13; TTK; UBE2C; UBE2S; ZWINT
GO:0031023	microtubule organizing center organization	10.90	2.30e-13	6.94e-12	16/43	AURKA; BRCA1; BRCA2; CCNF; CDK1; CHEK1; CNTLN; PCLAF; KIF11; NEK2; PLK1; PLK4; POC1A; SGO1; STIL; WDR62
GO:0044843	cell cycle G1/S phase transition	10.50	0.00e+00	0.00e+00	39/109	AURKA; CCNA2; CCNB1; CCNE1; CCNE2; CDC25A; CDC25C; CDC45; CDC6; CDC7; CDK1; CDKN2C; CDKN2D; CDKN3; CDT1; DBF4; E2F1; E2F7; E2F8; EZH2; FAM83D; FBXO5; GMNN; GTSE1; IQGAP3; KIF14; MCM10; MCM2; MCM4; MCM5; MCM6; MCM7; MTBP; ORC1; POLE2; RBL1; RRM2; SKP2; TYMS
GO:1901987	regulation of cell cycle phase transition	10.50	0.00e+00	0.00e+00	53/149	ANLN; ATAD5; AURKA; AURKB; BLM; BRCA1; BUB1B; BUB1; TICRR; CCNB1; CCNE1; CDC20; CDC25A; CDC25B; CDC25C; CDC45; CDC6; CDC7; CDCA5; CDK1; CDKN2D; CDT1; CENPE; CENPF; CHEK1; CLSPN; DLGAP5; DTL; E2F1; E2F7; E2F8; ESPL1; EZH2; FAM83D; FBXO5; GTSE1; HMMR; KIF14; KNTC1; MAD2L1; MTBP; NDC80; NEK2; ORC1; PLK1; PLK4; RAD51C; RBL1; RECQL4; TPX2; TRIP13; TTK; UBE2C
GO:0010948	negative regulation of cell cycle process	10.30	0.00e+00	0.00e+00	39/111	AURKA; AURKB; BLM; BRCA1; BUB1B; BUB1; TICRR; CCNB1; CCNF; CDC20; CDC25C; CDC6; CDC7; CDK1; CDKN2D; CDT1; CENPF; CHEK1; CLSPN; DTL; E2F1; E2F7; E2F8; ESPL1; EZH2; FBXO5; GTSE1; MAD2L1; MTBP; NDC80; NEK2; ORC1; PLK1; PTTG1; RAD51; RBL1; RRM2; TRIP13; TTK
GO:0051321	meiotic cell cycle	9.73	0.00e+00	0.00e+00	43/130	ASPM; AURKA; BLM; BRCA2; BRIP1; BUB1B; BUB1; CCNE1; CCNE2; CDC20; CDC25A; CDC25B; CDC25C; CKS2; EME1; ESPL1; EXO1; FANCA; FBXO5; H2AFX; KIF18A; MND1; MNS1; MYBL1; NCAPD2; NCAPH; NEK2; NUF2; PKMYT1; PLK1; PTTG1; RAD51C; RAD51; RAD54B; RAD54L; SGO1; SGO2; SMC4; SYCE2; NDC1; TOP2A; TRIP13; TTK
GO:0006310	DNA recombination	9.71	0.00e+00	0.00e+00	33/100	ATAD5; BLM; BRCA1; BRCA2; BRIP1; PARPBP; RMI2; AUNIP; CDC45; CDC7; CHEK1; EME1; EXO1; FANCB; FEN1; GINS2; GINS4; H2AFX; HMGB2; KPNA2; MND1; TONSL; PIF1; POLQ; RAD51AP1; RAD51C; RAD51; RAD54B; RAD54L; RECQL4; ALYREF; TOP2A; TRIP13
GO:1904029	regulation of cyclin-dependent protein kinase activity	9.63	9.35e-14	2.93e-12	18/55	BLM; CCNA2; CCNB1; CCNB2; CCNE1; CCNE2; CCNF; CDC25A; CDC25C; CDC6; CDKN2C; CDKN2D; CDKN3; CKS1B; CKS2; PKMYT1; PLK1; PSRC1
GO:0033044	regulation of chromosome organization	9.62	0.00e+00	0.00e+00	34/104	ATAD2; AURKB; BRCA1; BUB1B; BUB1; RMI2; CCNB1; CDC20; CDC45; CDC6; CDCA5; CDT1; CENPE; CENPF; CHEK1; DDX11; DLGAP5; DNMT3B; ESPL1; FBXO5; FEN1; MAD2L1; MCM2; MKI67; NDC80; NEK2; PHF19; PIF1; PLK1; PTTG1; TACC3; TOP2A; TRIP13; TTK
GO:0045930	negative regulation of mitotic cell cycle	9.11	0.00e+00	0.00e+00	35/113	AURKA; AURKB; BLM; BRCA1; BUB1B; BUB1; TICRR; CCNB1; CDC20; CDC25C; CDC6; CDK1; CDT1; CENPF; CHEK1; CLSPN; E2F1; E2F7; E2F8; EME1; EZH2; FBXO5; GTSE1; KNTC1; MAD2L1; MTBP; NDC80; ORC1; PLK1; PTTG1; RBL1; TOP2A; TRIP13; TTK; ZWINT
GO:0071166	ribonucleoprotein complex localization	9.05	7.31e-04	9.60e-03	4/13	DDX39A; NUP210; ALYREF; NDC1
GO:0006289	nucleotide-excision repair	8.65	1.93e-04	2.66e-03	5/17	BRCA2; BRIP1; NEIL3; POLD1; RFC4
GO:0042770	signal transduction in response to DNA damage	8.49	8.96e-11	2.21e-09	15/52	ATAD5; AURKA; BRCA1; BRCA2; CCNB1; CDC25C; CDK1; CHEK1; DTL; E2F1; E2F7; E2F8; FOXM1; GTSE1; PLK1
GO:0071897	DNA biosynthetic process	8.34	6.58e-12	1.73e-10	17/60	AURKB; BLM; CDKN2D; CENPF; CHTF18; DSCC1; DTL; PCLAF; LIN9; NEK2; PIF1; POLD1; POLE2; POLQ; RFC4; TK1; TYMS
GO:0071824	protein-DNA complex subunit organization	8.25	1.33e-15	4.72e-14	23/82	ANP32E; ASF1B; KNL1; CDC45; CDT1; CENPA; CENPE; CENPF; CENPI; CENPK; CENPM; CENPN; CENPW; CHAF1B; GMNN; H2AFX; HELLS; HJURP; HMGB2; MCM2; CENPU; OIP5; RAD51
GO:0006338	chromatin remodeling	8.24	6.02e-10	1.36e-08	14/50	ANP32E; KNL1; CENPA; CENPI; CENPK; CENPM; CENPN; CENPW; CHEK1; HELLS; HJURP; HMGB2; CENPU; OIP5
GO:0045787	positive regulation of cell cycle	8.16	0.00e+00	0.00e+00	53/191	ATAD5; AURKA; AURKB; BRCA1; BRCA2; CCNA2; CCNB1; CCNB2; CCNE1; CCNE2; CCNF; CDC25A; CDC25B; CDC25C; CDC45; CDC6; CDC7; CDCA5; CDK1; CDT1; CHEK1; CIT; CKS1B; CKS2; DDX11; DLGAP5; DTL; E2F1; E2F7; E2F8; ECT2; ESPL1; EZH2; FAM83D; FBXO5; FEN1; GPSM2; GTSE1; KIF14; KIF23; MAD2L1; MTBP; NDC80; NUSAP1; PLK4; POC1A; PSRC1; RACGAP1; RAD51C; RECQL4; SPAG5; TP73; UBE2C
GO:0044380	protein localization to cytoskeleton	8.02	6.85e-05	9.96e-04	6/22	ANLN; AURKA; FAM83D; SPAG5; STIL; TTK
GO:0051052	regulation of DNA metabolic process	7.61	0.00e+00	0.00e+00	38/147	ATAD5; AURKB; BLM; BRCA1; BRCA2; PARPBP; TICRR; RMI2; AUNIP; CCNA2; CDC6; CDC7; CDK1; CDT1; CHEK1; CHTF18; DBF4; DDX11; DEK; DNA2; DSCC1; E2F7; E2F8; ESCO2; FANCB; FBXO5; FOXM1; GMNN; H2AFX; KPNA2; NEK2; PIF1; POLQ; RAD51AP1; RAD51; RECQL4; RFC4; ALYREF
GO:0006333	chromatin assembly or disassembly	7.47	1.73e-10	4.14e-09	16/63	ASF1B; KNL1; CENPA; CENPI; CENPK; CENPM; CENPN; CENPW; CHAF1B; H2AFX; HELLS; HJURP; HMGB2; MCM2; CENPU; OIP5
GO:2001020	regulation of response to DNA damage stimulus	7.17	7.06e-12	1.80e-10	19/78	ATAD5; BLM; BRCA1; DDIAS; PARPBP; RMI2; AUNIP; CDKN2D; CHEK1; DDX11; DEK; FANCB; FBXO5; FOXM1; H2AFX; POLQ; RAD51AP1; RAD51; WDR76
GO:0031109	microtubule polymerization or depolymerization	6.30	2.70e-07	5.23e-06	12/56	CKAP2; FBXO5; KIF14; KIF18A; KIF18B; KIF24; KIF2C; PSRC1; SKA1; SKA2; SKA3; STMN1
GO:0006997	nucleus organization	6.24	9.65e-05	1.38e-03	7/33	CCNB1; CCNB2; CDK1; CEP55; HMGB2; PLK1; NDC1
GO:0032886	regulation of microtubule-based process	6.11	4.72e-12	1.28e-10	22/106	AURKA; BRCA1; CCNF; CHEK1; CKAP2; CNIH2; GPSM2; KIF11; KIF18A; NEK2; PLK1; PLK4; POC1A; PSRC1; SKA1; SKA2; SKA3; SPAG5; STIL; STMN1; TACC3; TPX2
GO:0072331	signal transduction by p53 class mediator	5.88	2.53e-09	5.43e-08	17/85	ATAD5; AURKA; AURKB; BRCA1; BRCA2; CCNB1; CDC25C; CDK1; CHEK1; E2F1; E2F2; E2F7; E2F8; FOXM1; GTSE1; TP73; TPX2
GO:0051302	regulation of cell division	5.82	3.41e-10	7.94e-09	19/96	ASPM; AURKA; AURKB; BLM; BRCA2; CDC25B; CDC6; CIT; E2F7; E2F8; ECT2; KIF14; KIF18B; KIF20A; KIF23; PLK1; PRC1; RACGAP1; RBL1
GO:0010639	negative regulation of organelle organization	5.05	7.15e-13	2.01e-11	28/163	ATAD2; AURKB; BRCA1; BUB1B; BUB1; CCNB1; CCNF; CDC20; CDT1; CENPF; CHEK1; CKAP2; DNMT3B; ESPL1; FBXO5; MAD2L1; MCM2; MTBP; NDC80; NEK2; PIF1; PLK1; PTTG1; STMN1; TMSB15A; TMSB15B; TOP2A; TRIP13; TTK
GO:0007050	cell cycle arrest	4.86	2.09e-08	4.36e-07	18/109	AURKA; BARD1; BRCA1; DDIAS; CCNB1; CDC25C; CDK1; CDKN2C; CDKN2D; CDKN3; E2F1; E2F7; E2F8; FOXM1; GTSE1; MTBP; PRR11; TP73
GO:0007292	female gamete generation	4.84	2.11e-06	3.66e-05	13/79	ASPM; AURKA; BRCA2; CCNB1; CDC25B; FBXO5; NCAPH; PLK1; RAD51C; TOP2A; TRIP13; TTK; YBX2
GO:0040029	regulation of gene expression, epigenetic	4.75	3.89e-05	5.98e-04	10/62	ATAD2; BRCA1; CDC45; CHEK1; DEK; DNMT3B; EZH2; HELLS; LHX2; PHF19
GO:1903320	regulation of protein modification by small protein conjugation or removal	4.20	1.13e-04	1.59e-03	10/70	BRCA1; CDC20; FANCI; FBXO5; MAD2L1; MTBP; PLK1; SKP2; UBE2C; UBE2S
GO:0010498	proteasomal protein catabolic process	4.02	1.83e-06	3.24e-05	16/117	AURKA; AURKB; BUB1B; CCNB1; CCNF; CDC20; CDK1; FBXO5; KIF14; MAD2L1; PBK; PLK1; PTTG1; SKP2; UBE2C; UBE2S
GO:0070646	protein modification by small protein removal	3.86	9.86e-04	1.27e-02	8/61	BARD1; BRCA1; CCNA2; CDC20; CDC25A; CDK1; CLSPN; SKP2
GO:0090305	nucleic acid phosphodiester bond hydrolysis	3.82	2.54e-04	3.44e-03	10/77	ATAD5; DNA2; EME1; EXO1; FEN1; HMGB2; REXO5; POLD1; RFC4; RNASEH2A
GO:0007018	microtubule-based movement	3.68	6.07e-06	1.01e-04	16/128	CENPE; CNIH2; DLGAP5; KIF11; KIF14; KIF15; KIF18A; KIF18B; KIF20A; KIF23; KIF24; KIF2C; KIF4A; KIFC1; RACGAP1; WDR34
GO:0051169	nuclear transport	3.41	3.50e-04	4.68e-03	11/95	BARD1; CCHCR1; CDK1; DDX39A; ECT2; GTSE1; KPNA2; NUP210; PSIP1; ALYREF; NDC1
GO:0016569	covalent chromatin modification	3.32	4.12e-05	6.22e-04	15/133	AURKA; AURKB; BRCA1; BRCA2; CCNA2; CCNB1; CDK1; CHEK1; DNMT3B; EZH2; HASPIN; HELLS; PHF19; SAP30; UHRF1
GO:0051656	establishment of organelle localization	3.28	1.30e-07	2.58e-06	25/224	SAPCD2; CCNB1; CDCA5; CDCA8; CDT1; CENPA; CENPE; CENPF; CEP55; CNIH2; CSPG5; DLGAP5; ESPL1; FAM83D; GPSM2; KIF14; KIF18A; KIF23; KIF2C; KIFC1; NDC80; NUF2; NUSAP1; PSRC1; SPAG5
GO:0031503	protein-containing complex localization	3.27	2.91e-03	3.59e-02	8/72	BIRC5; CNIH2; DDX39A; HASPIN; NUP210; ALYREF; NDC1; WDR34
GO:0009314	response to radiation	3.10	6.18e-06	1.01e-04	20/190	AURKB; BLM; BRCA1; BRCA2; TICRR; CDC25A; CDKN2D; CHEK1; DNMT3B; DTL; ECT2; FEN1; H2AFX; PCLAF; NMU; PBK; POLD1; RAD51AP1; RAD51; RAD54L
GO:0019882	antigen processing and presentation	3.01	2.88e-03	3.59e-02	9/88	CENPE; CTSV; KIF11; KIF15; KIF18A; KIF23; KIF2C; KIF4A; RACGAP1
GO:0022412	cellular process involved in reproduction in multicellular organism	3.01	1.64e-05	2.61e-04	19/186	ASPM; AURKA; BRCA2; BRIP1; KNL1; CCNB1; CDC25B; FANCA; FBXO5; HMGB2; KIF18A; MYBL1; NCAPH; PLK1; RAD51C; TOP2A; TRIP13; TTK; YBX2
GO:0051493	regulation of cytoskeleton organization	2.57	1.87e-05	2.93e-04	24/275	AURKA; BRCA1; CCNF; CHEK1; CIT; CKAP2; ECT2; GPSM2; KIF11; KIF18A; NEK2; PLK1; PLK4; POC1A; PSRC1; SKA1; SKA2; SKA3; SPAG5; STIL; STMN1; TACC3; TMSB15A; TMSB15B; TPX2
GO:0071900	regulation of protein serine/threonine kinase activity	2.38	6.56e-05	9.71e-04	24/297	BLM; CCNA2; CCNB1; CCNB2; CCNE1; CCNE2; CCNF; CDC25A; CDC25C; CDC6; CDK1; CDKN2C; CDKN2D; CDKN3; CKS1B; CKS2; DBF4; EZH2; IQGAP3; PKMYT1; PLK1; PSRC1; TIAM1; TP73
GO:0060249	anatomical structure homeostasis	2.33	9.95e-04	1.27e-02	17/215	AURKB; BARD1; BLM; BRCA2; CCNE1; CCNE2; DNA2; EXO1; FEN1; NEK2; PIF1; POLD1; RAD51C; RAD51; RECQL4; RFC4; TYRO3
GO:0051098	regulation of binding	2.29	3.19e-03	3.88e-02	14/180	AURKA; AURKB; CDCA5; CDT1; DDX11; E2F1; GMNN; HJURP; HMGB2; LHX2; NEK2; PLK1; STMN1; TIAM1

Factor 14 : 59 significant GO terms

GeneSet	description	enrichRatio	pValue	FDR	GeneRatio	geneSymbols
GO:0044321	response to leptin	6.39	2.67e-03	3.29e-02	4/13	EDN1; LEPR; LEP; NR4A3
GO:0090077	foam cell differentiation	5.19	7.66e-04	1.27e-02	6/24	ADIPOQ; APOB; CD36; LPL; PLA2G2A; PPARG
GO:0010644	cell communication by electrical coupling	4.72	3.35e-03	3.97e-02	5/22	ATP1A2; CASQ2; CAV1; KCNA1; TRDN
GO:0061614	pri-miRNA transcription by RNA polymerase II	4.45	1.82e-03	2.56e-02	6/28	ATOH8; FOS; KLF4; NGFR; PPARG; PRL
GO:0042180	cellular ketone metabolic process	4.23	5.87e-09	1.49e-06	22/108	ABCD2; ACACB; ACADL; ADH4; ADIPOQ; AKR1C1; AKR1C2; AKR1C3; BHMT; BMP6; CAV1; CNR1; CYP19A1; DGAT2; DKK3; EGR1; FABP5; GPD1; MLXIPL; NR4A3; PDK4; PPARG
GO:0050886	endocrine process	4.09	1.20e-05	5.42e-04	13/66	AVPR2; BMP6; CMA1; CORIN; CRHBP; CTSG; EDN1; FZD4; HCAR2; LEP; MME; RETN; SUCNR1
GO:2001057	reactive nitrogen species metabolic process	4.00	1.52e-04	3.64e-03	10/52	CAV1; CD36; EDN1; HBB; KLF2; KLF4; MMP8; MARC1; PTGIS; PTX3
GO:0006638	neutral lipid metabolic process	3.94	4.13e-06	1.98e-04	15/79	ACSL1; GPAT3; APOB; CAV1; DGAT2; FABP12; FABP4; FABP5; GPAM; LIPE; LPL; PCK1; PNPLA2; THRSP; AGMO
GO:0016999	antibiotic metabolic process	3.78	1.46e-05	6.27e-04	14/77	ADH1A; ADH1B; ADH1C; ADH4; AKR1C1; AKR1C2; AKR1C3; ALDH2; GPX3; HBA1; HBB; HP; PCK1; TPO
GO:0005976	polysaccharide metabolic process	3.53	8.46e-04	1.35e-02	9/53	CHIT1; GYG2; GYS2; HAS1; IGF1; PHKG1; PPP1R1A; PYGM; SORBS1
GO:0008643	carbohydrate transport	3.46	7.65e-05	2.01e-03	13/78	ADIPOQ; AQP7; AQP9; EDN1; FABP5; GPC3; IGF1; KLF15; LEP; NR4A3; SLC2A4; SORBS1; TRARG1
GO:0032602	chemokine production	3.46	5.14e-04	9.29e-03	10/60	ADIPOQ; ACKR1; EGR1; ELANE; FFAR3; IL33; IL6; KLF4; LBP; LPL
GO:0019216	regulation of lipid metabolic process	3.45	2.01e-11	1.64e-08	37/223	ABCD2; ACACB; ACADL; ACSL1; ADIPOQ; AKR1C3; ANGPTL4; APOB; BMP6; CAV1; CCL19; CD36; CIDEA; CNR1; DGAT2; DKK3; EGR1; FABP5; FGF2; FGR; G0S2; GPAM; HCAR2; KLF4; LEP; LGALS12; ANGPTL8; MLXIPL; NR4A3; PDE3B; PDK4; PLIN2; PNPLA2; PPARG; SOCS3; SORBS1; THRSP
GO:0055088	lipid homeostasis	3.42	4.66e-05	1.52e-03	14/85	AKR1C1; ANGPTL4; APOB; CAV1; CEBPA; DGAT2; FABP4; GPAM; GPIHBP1; ANGPTL8; LPL; MLXIPL; PNPLA2; PPARG
GO:0002526	acute inflammatory response	3.32	3.37e-06	1.90e-04	19/119	C2CD4B; C5AR1; C6; C7; CD163; CFP; CNR1; CR1; DNASE1L3; ELANE; FFAR3; HPR; HP; IL6; LBP; PPARG; SAA1; SAA2; SAA4
GO:1990845	adaptive thermogenesis	3.21	5.37e-05	1.63e-03	15/97	ACADL; ACSL1; ADIPOQ; ADRB1; ADRB3; CAV1; CD36; CIDEA; ELOVL3; FABP4; FABP5; G0S2; LEPR; LEP; VEGFA
GO:0097305	response to alcohol	3.21	5.76e-07	4.69e-05	23/149	ADIPOQ; AKR1C2; AKR1C3; CA3; CCL19; CDO1; CNR1; CRHBP; CSF3; CSN1S1; FOSB; FOS; GSN; KLF2; KLF4; LEP; PENK; PPARG; PRL; PTGER4; PTGFR; RBP4; SLC2A4
GO:0016051	carbohydrate biosynthetic process	3.13	2.48e-05	9.19e-04	17/113	ADIPOQ; ATF3; DGAT2; GPD1; GYG2; GYS2; HAS1; IGF1; LEPR; LEP; LHCGR; PCK1; PFKFB1; PHKG1; PTH1R; RBP4; SORBS1
GO:0006109	regulation of carbohydrate metabolic process	3.10	2.40e-04	5.37e-03	13/87	ACACB; ADIPOQ; DGAT2; GPD1; IGF1; LEPR; LEP; LHCGR; MLXIPL; PDK4; PFKFB1; PTH1R; SORBS1
GO:0050918	positive chemotaxis	3.08	3.97e-03	4.37e-02	8/54	ANGPT2; FGF2; VEGFD; S1PR1; SAA1; SAA2; SAA4; VEGFA
GO:0097006	regulation of plasma lipoprotein particle levels	3.08	3.97e-03	4.37e-02	8/54	ADIPOQ; APOB; CD36; DGAT2; GPIHBP1; LPL; PLA2G2A; PLA2G7
GO:0046677	response to antibiotic	2.97	4.98e-07	4.69e-05	26/182	ADIPOQ; ALPL; AOC3; CA3; CDO1; CNR1; CRHBP; CRYAB; CSF3; DUSP1; EDN1; EGR1; GSN; HBA1; HBB; HP; HYAL1; IL6; KLF2; KLF4; LEP; NR4A3; PENK; PRL; RBP4; SLC2A4
GO:0050727	regulation of inflammatory response	2.93	3.90e-09	1.49e-06	36/255	ABCD2; ADIPOQ; C2CD4B; C5AR1; C6; C7; CCL14; CCL18; CCL24; CEBPA; CFP; CMA1; CNR1; CR1; CYP19A1; DNASE1L3; ELANE; FABP4; FFAR3; IL33; IL6; KLF4; LBP; LEP; LPL; MMP8; PDE2A; PLA2G2A; PLA2G7; PPARG; PTGER4; PTGIS; SAA1; SOCS3; SUCNR1; TYRO3
GO:0062012	regulation of small molecule metabolic process	2.92	4.12e-07	4.69e-05	27/192	ABCD2; ACACB; ACADL; ADIPOQ; AKR1C3; APOB; BHMT; BMP6; CAV1; CNR1; DGAT2; DKK3; EGR1; FABP5; GPAM; GPD1; IGF1; LEPR; LEP; LHCGR; MLXIPL; NR4A3; PDK4; PFKFB1; PPARG; PTH1R; SORBS1
GO:0010876	lipid localization	2.92	7.32e-09	1.49e-06	35/249	ABCA10; ABCA6; ABCA8; ABCA9; ABCD2; ACACB; ACSL1; ACVR1C; ADIPOQ; AKR1C1; APOB; AQP9; BMP6; SPX; CAV1; CD36; CES1; CIDEA; CYP19A1; DGAT2; EDN1; FABP4; FZD4; IL6; LBP; LEP; LPL; NMB; PLA2G2A; PLIN2; PNPLA2; PPARG; RBP4; RETN; THRSP
GO:0046683	response to organophosphorus	2.90	4.69e-04	8.77e-03	13/93	ADIPOQ; AKR1C1; AQP9; CDO1; CRHBP; DUSP1; FOSB; FOS; GPD1; PCK1; PDE2A; PENK; PFKFB1
GO:0014074	response to purine-containing compound	2.88	3.12e-04	6.36e-03	14/101	ADIPOQ; AQP9; CASQ2; CDO1; CRHBP; DUSP1; FOSB; FOS; GPD1; PCK1; PDE2A; PENK; PFKFB1; PPARG
GO:0070555	response to interleukin-1	2.81	6.40e-04	1.11e-02	13/96	CCL13; CCL14; CCL18; CCL19; CCL23; CCL24; EDN1; EGR1; HYAL1; IL6; KLF2; PCK1; PTGIS
GO:0016042	lipid catabolic process	2.78	1.74e-06	1.18e-04	26/194	ABCD2; ACACB; ACADL; ADIPOQ; AKR1C3; APOB; CES1; CIDEA; CNR1; CYP19A1; ENPP2; FABP12; FABP4; FABP5; HCAR2; LEP; LGALS12; LIPE; LPL; PCK1; PDE3B; PLA2G2A; PLA2G7; PLCXD3; PLIN1; PNPLA2
GO:0001101	response to acid chemical	2.78	2.73e-07	3.71e-05	30/224	ACSL1; ADIPOQ; AKR1C1; AKR1C2; AKR1C3; ALDH1A2; APOB; BMP6; CCL19; CD36; CDO1; DGAT2; DUSP1; EDN1; EGR1; FFAR3; FOLR2; FZD4; GSN; KLF2; KLF4; LEP; OTC; PCK1; PDK4; PPARG; PTGER4; PTGFR; RBP4; VEGFA
GO:1901342	regulation of vasculature development	2.75	5.55e-07	4.69e-05	29/219	ANGPT2; ANGPTL4; BMPER; C5AR1; C6; CCL24; CMA1; EGR1; ENPP2; FGF2; VEGFD; HSPB6; HYAL1; IL6; KLF2; KLF4; LEP; MEOX2; NGFR; NPR1; PDE3B; PPARG; PRL; PROK1; PTGIS; THBS4; TMEM100; TNMD; VEGFA
GO:0033500	carbohydrate homeostasis	2.74	5.50e-05	1.63e-03	19/144	ADIPOQ; CEBPA; CMA1; CNR1; FABP5; GPR21; KCNB1; KLF15; LEPR; LEP; MLXIPL; NGFR; NMB; PCK1; PDK4; PPARG; RABGAP1; RBP4; SLC2A4; SUCNR1
GO:0044262	cellular carbohydrate metabolic process	2.69	1.10e-04	2.72e-03	18/139	ACACB; ADIPOQ; DGAT2; GYG2; GYS2; HAS1; IGF1; LEPR; LEP; LHCGR; PCK1; PDK4; PFKFB1; PHKG1; PPP1R1A; PTH1R; PYGM; SORBS1
GO:0045444	fat cell differentiation	2.69	1.10e-04	2.72e-03	18/139	ADIPOQ; ADRB1; MEDAG; CEBPA; EGR2; FABP4; GDF10; IL6; KLF4; LEP; LGALS12; ANGPTL8; NR4A1; NR4A3; PPARG; RETN; SLC2A4; ZFP36
GO:0042445	hormone metabolic process	2.69	1.95e-05	7.56e-04	22/170	ADH4; AKR1C1; AKR1C2; AKR1C3; ALDH1A2; BMP6; CMA1; CORIN; CRHBP; CTSG; CYP19A1; DGAT2; DKK3; EGR1; FFAR3; GHR; HSD11B1; LEP; MME; RBP4; RDH5; TPO
GO:0006091	generation of precursor metabolites and energy	2.67	3.74e-06	1.90e-04	26/202	ADH1A; ADH1B; ADH1C; ADH4; ADIPOQ; ADRB3; ALDH2; AOC2; AOX1; AQP7; CEBPA; CYP19A1; DMGDH; GPD1; GYG2; GYS2; IGF1; LEPR; LEP; MLXIPL; NR4A3; PFKFB1; PHKG1; PPP1R1A; PYGM; SORBS1
GO:1901652	response to peptide	2.67	7.29e-08	1.19e-05	35/272	ACVR1C; ADIPOQ; CAV1; CD36; CDO1; CRHBP; EDN1; EGR1; EGR2; FFAR3; GHR; GLP2R; GPR21; IGF1; KLF15; KLF2; KLF4; LEP; LHCGR; NGFR; NR4A1; NR4A3; OTC; PCK1; PDE3B; PDK4; PFKFB1; PPARG; PRL; RABGAP1; RETN; SLC2A4; SOCS3; SORBS1; TIMP4; TRARG1
GO:0032103	positive regulation of response to external stimulus	2.66	2.71e-06	1.70e-04	27/211	BMP6; C2CD4B; C5AR1; CCL14; CCL18; CCL19; CCL24; CEBPA; CNR1; EDN1; FABP4; FFAR3; FGF2; VEGFD; IL33; IL6; LBP; LPL; MMP8; PDE2A; PLA2G2A; PLA2G7; PTGER4; S1PR1; SUCNR1; THBS4; VEGFA
GO:0002576	platelet degranulation	2.66	2.62e-03	3.29e-02	11/86	CD36; CFD; CLEC3B; VEGFD; IGF1; LEFTY2; PECAM1; SELP; TF; VEGFA; VWF
GO:0034612	response to tumor necrosis factor	2.63	6.40e-05	1.80e-03	20/158	ADIPOQ; APOB; CCL13; CCL14; CCL18; CCL19; CCL23; CCL24; CEBPA; CRHBP; EDN1; FABP4; GPD1; HYAL1; KLF2; PCK1; SLC2A4; DCSTAMP; TNFRSF8; ZFP36
GO:0072593	reactive oxygen species metabolic process	2.48	2.11e-04	4.90e-03	19/159	ABCD2; AKR1C3; CAV1; CD36; CRYAB; EDN1; GPX3; HBA1; HBB; HP; KLF2; KLF4; LEP; MMP8; PDK4; PTGIS; PTX3; SOD3; TPO
GO:1901654	response to ketone	2.47	1.00e-03	1.54e-02	15/126	AKR1C2; AKR1C3; CAV1; CCL19; CSN1S1; DUSP1; EDN1; FOSB; FOS; KLF2; KLF4; PCK1; PPARG; PTGER4; PTGFR
GO:0050920	regulation of chemotaxis	2.40	4.74e-04	8.77e-03	18/156	ANGPT2; C5AR1; CCL19; CYP19A1; DUSP1; EDN1; ELANE; FGF2; VEGFD; IL6; LBP; PLA2G7; PLXNA4; S1PR1; SEMA3G; SUCNR1; THBS4; VEGFA
GO:0006631	fatty acid metabolic process	2.38	3.11e-05	1.10e-03	26/227	ABCD2; ACACB; ACADL; ACSL1; ACSM5; ADIPOQ; AKR1C2; AKR1C3; CAV1; CD36; CES1; CNR1; DGAT2; EDN1; ELOVL3; FABP5; GPAM; LEP; LIPE; LPL; MLXIPL; NR4A3; PCK1; PDK4; PPARG; PTGIS
GO:0009636	response to toxic substance	2.37	1.41e-06	1.04e-04	35/307	ADIPOQ; ATP1A2; CA3; CD36; CDO1; CES1; CNR1; CRHBP; CRYAB; CSF3; DUSP1; EDN1; EGR1; FOS; GLYAT; GPX3; GSN; HBA1; HBB; HP; IL6; INMT; KLF2; KLF4; LEP; MARC1; MT1M; NR4A3; PDE1B; PENK; PRL; RBP4; SLC2A4; SOD3; TPO
GO:0060326	cell chemotaxis	2.32	6.81e-05	1.85e-03	25/224	C5AR1; CCL13; CCL14; CCL18; CCL19; CCL23; CCL24; CH25H; CXCL2; CYP19A1; DUSP1; EDN1; FGF2; VEGFD; FOLR2; IL6; LBP; NR4A1; PLA2G7; S1PR1; SAA1; SAA2; SAA4; THBS4; VEGFA
GO:0048511	rhythmic process	2.31	7.47e-04	1.27e-02	18/162	ADAMTS1; ADIPOQ; EGR1; EGR2; FZD4; HAS1; HS3ST2; LEP; LHCGR; NGFR; NLGN1; PPARG; PRL; PROK1; PTX3; RETN; TIMP4; TYRO3
GO:0051235	maintenance of location	2.27	3.43e-04	6.81e-03	21/192	ACACB; ACVR1C; ANK2; APOB; ATP1A2; SYNE3; CASQ2; CAV1; CCL19; CD36; CIDEA; DGAT2; FGF2; GSN; IL6; LEP; LPL; PLIN2; PNPLA2; PPARG; TRDN
GO:0016053	organic acid biosynthetic process	2.26	3.86e-05	1.31e-03	28/257	ABCD2; ACACB; ACADL; ACSM5; ADIPOQ; AKR1C3; ALDH1A2; ASPA; BHMT2; BHMT; CDO1; CH25H; EDN1; ELOVL3; FABP5; FOLH1; GPD1; HAS1; HYAL1; IGF1; LPL; MLXIPL; NAALAD2; NAT8L; OTC; PDK4; PFKFB1; PTGIS
GO:1901615	organic hydroxy compound metabolic process	2.24	3.73e-06	1.90e-04	36/334	ACACB; ACADL; ADH1A; ADH1B; ADH1C; ADH4; AKR1C1; AKR1C2; AKR1C3; ALDH1A2; ALDH2; AOC2; APOB; BMP6; CEBPA; CES1; CH25H; CYP19A1; DGAT2; DKK3; FGF2; GPAM; GPD1; IGF1; LEPR; LEP; LHCGR; LIPE; MAOA; NPR1; PCK1; PDE1B; PTH1R; RBP4; RDH5; TPO
GO:0006979	response to oxidative stress	2.18	2.52e-04	5.40e-03	24/229	ADIPOQ; AKR1C3; ANGPTL7; CA3; CCL19; CD36; CRYAB; DUSP1; EDN1; FOS; GPX3; HBA1; HBB; HP; HYAL1; IL6; KLF2; KLF4; MCTP1; NR4A3; PENK; SGK2; SOD3; TPO
GO:0006909	phagocytosis	2.16	3.80e-03	4.29e-02	15/144	ADIPOQ; CD36; ELANE; FCN1; FGR; GSN; LBP; LEPR; LEP; PEAR1; PECAM1; PPARG; PTX3; SRPX; TYRO3
GO:0048545	response to steroid hormone	2.15	3.07e-04	6.36e-03	24/232	ADIPOQ; AKR1C3; ALPL; ATP1A2; BMP6; CAV1; CDO1; CSN1S1; DUSP1; EDN1; FAM107A; FOSB; FOS; GPAM; IL6; LBH; NR4A1; NR4A3; PCK1; PFKFB1; PPARG; RXRG; S100B; ZFP36
GO:0002237	response to molecule of bacterial origin	2.14	4.27e-04	8.27e-03	23/223	ALPL; APOB; BMP6; C5AR1; CD36; CNR1; CSF3; CTSG; CXCL2; EDN1; ELANE; FOS; IL6; LBP; MRC1; PCK1; PENK; PRL; PTGER4; PTGFR; SELP; TIMP4; ZFP36
GO:0001525	angiogenesis	2.11	1.95e-05	7.56e-04	35/345	ANGPT2; ANGPTL4; BMPER; C5AR1; C6; CAV1; CCL24; CMA1; EDN1; ENPP2; ESM1; FGF2; VEGFD; HSPB6; HYAL1; IL6; KLF2; KLF4; LEPR; LEP; MEOX2; NGFR; NPR1; NR4A1; PDE3B; PECAM1; PPARG; PRL; PROK1; PTGIS; S1PR1; THBS4; TMEM100; TNMD; VEGFA
GO:0009410	response to xenobiotic stimulus	2.10	1.30e-03	1.96e-02	20/198	ACSL1; AKR1C1; AOC2; AOC3; CASQ2; CDO1; CES1; CNR1; CRHBP; EDN1; EGR1; FMO2; FOSB; GHR; GLYAT; PCK1; PDE1B; PDE2A; PENK; PPARG
GO:0050900	leukocyte migration	2.08	5.61e-05	1.63e-03	32/319	ANGPT2; APOB; C5AR1; CAV1; CCL13; CCL14; CCL18; CCL19; CCL23; CCL24; CH25H; CXCL2; CYP19A1; DUSP1; EDN1; ELANE; VEGFD; FOLR2; GYPC; IL33; IL6; LBP; LEP; PECAM1; PLA2G7; PTGER4; S1PR1; SAA1; SELP; SLC7A10; THBS4; VEGFA
GO:0006732	coenzyme metabolic process	2.08	1.91e-03	2.64e-02	19/190	ACACB; ACSL1; ACSM5; ALDH1L1; BHMT2; BHMT; DGAT2; ELOVL3; FMO2; FOLH1; FOLR2; GLYAT; GPAM; GPD1; IGF1; MLXIPL; PDK4; PFKFB1; PTGIS
GO:0015850	organic hydroxy compound transport	2.08	2.50e-03	3.29e-02	18/180	ADIPOQ; AKR1C1; APOB; AQP7; AQP9; BMP6; CAV1; CD36; CES1; CNR1; CYP19A1; FFAR3; KCNB1; LEP; PPARG; RBP4; SLC16A7; SLC22A3

Factor 15 : 6 significant GO terms

GeneSet	description	enrichRatio	pValue	FDR	GeneRatio	geneSymbols
GO:0001539	cilium or flagellum-dependent cell motility	18.90	1.88e-12	3.82e-10	11/22	DRC1; CCDC65; DNAH2; DNAH3; DNAH6; DNAH7; SPEF1; TEKT1; TEKT2; TEKT3; CFAP57
GO:0001578	microtubule bundle formation	15.60	0.00e+00	0.00e+00	24/58	ARMC4; CFAP43; DRC1; CFAP206; CFAP157; CCDC103; CCDC114; CCDC65; DNAH7; DNAI1; DNAI2; DNAJB13; HYDIN; IQCG; LRGUK; LRRC49; DNAAF1; LRRC6; RSPH1; RSPH4A; TEKT2; TRIM46; TTLL6; ZMYND10
GO:0021591	ventricular system development	12.60	2.01e-04	2.72e-02	4/12	ARMC4; AK8; HYDIN; NME5
GO:0007018	microtubule-based movement	10.60	0.00e+00	0.00e+00	36/128	ARMC4; DRC1; MAATS1; CFAP206; CCDC103; CCDC114; CFAP53; CCDC65; DNAH12; DNAH2; DNAH3; DNAH6; DNAH7; DNAH9; DNAI1; DNAI2; HYDIN; KIF19; KIF24; KIF6; DNAAF1; LRRC6; MAK; NME5; CFAP221; ROPN1L; RSPH4A; SPA17; TEKT1; TEKT2; TEKT3; TRIM46; TTLL6; WDR63; WDR66; WDR78
GO:0044782	cilium organization	9.85	0.00e+00	0.00e+00	41/157	ARMC4; CFAP43; CFAP126; DRC1; CATIP; CFAP206; CFAP157; CCDC103; CCDC114; CFAP53; CCDC13; CCDC65; CCNO; DNAH7; DNAI1; DNAI2; DNAJB13; FAM92A; FOXJ1; HYDIN; IQCG; IQUB; KIF19; KIF24; LRGUK; LRRC49; DNAAF1; LRRC6; MAK; MAPK15; BBIP1; NME5; NPHP1; CFAP221; RSPH1; RSPH4A; TEKT1; TEKT2; TEKT3; WDR90; ZMYND10
GO:0097722	sperm motility	7.68	1.21e-07	1.98e-05	11/54	CFAP43; CFAP69; CFAP157; DNAI1; IQCG; LRRC6; ROPN1L; TCTE1; TEKT1; TEKT2; TEKT3

Factor 16 : 94 significant GO terms

GeneSet	description	enrichRatio	pValue	FDR	GeneRatio	geneSymbols
GO:0050690	regulation of defense response to virus by virus	8.44	7.01e-07	1.02e-05	8/13	B2M; CD247; CD28; CD4; CD8B; DOCK2; FYN; LCK
GO:0006968	cellular defense response	7.66	0.00e+00	0.00e+00	24/43	C5AR1; CCR2; CCR5; CCR6; CD19; CLEC5A; CXCL9; FCMR; GNLY; ITK; KIR2DL4; KIR3DL2; KLRC2; KLRC3; KLRG1; LSP1; NCF1; NCR1; PRF1; PTK2B; SH2D1A; SPN; TNFRSF4; TRAT1
GO:0002507	tolerance induction	7.22	1.97e-07	3.21e-06	10/19	CCR4; CD274; CD3E; FOXP3; HLA-E; ICOS; IDO1; IL2RA; PDCD1; TNFAIP3
GO:0001773	myeloid dendritic cell activation	6.86	3.69e-07	5.66e-06	10/20	BATF3; CAMK4; CD2; DOCK2; FLT3LG; IRF4; KLRK1; SLAMF1; TSPAN32; UBD
GO:0002250	adaptive immune response	6.60	0.00e+00	0.00e+00	128/266	B2M; BTK; BTLA; BTN3A1; BTN3A2; BTN3A3; C1QA; C1S; C3; C7; CAMK4; CCL19; CCR2; CCR6; CD1A; CD1B; CD1C; CD1D; CD1E; CD226; CD244; CD247; CD274; CD27; CD28; CD3D; CD3E; CD3G; CD40LG; CD40; CD48; CD4; CD6; CD74; CD79A; CD79B; CD7; CD8A; CD8B; CLEC10A; CLEC4A; CLEC4C; CLEC6A; CR1; CR2; CRTAM; CTLA4; CTSS; CXCL13; EBI3; EOMES; FCAMR; FCER2; FCRL4; FOXP3; FYN; GAPT; GPR183; GZMM; HLA-DQB1; HLA-E; HLA-F; IFNG; JCHAIN; IGLL1; IL12B; IL18R1; IL18RAP; IL18; IL33; IL7R; INPP5D; IRF1; IRF4; ITK; JAK3; KLHL6; KLRK1; LAMP3; LAT; LAX1; LILRB1; LIME1; LTA; LY9; MCOLN2; MYO1G; PAG1; PIK3CD; PIK3CG; POU2F2; PRDM1; PRF1; PRKCB; PRKCQ; PTK2B; PTPRC; RFTN1; SAMSN1; SASH3; SH2D1A; SH2D1B; SIT1; SLA2; SLAMF1; SLAMF6; SLAMF7; SLC11A1; SPN; SYK; TAP1; TAP2; TBX21; THEMIS; TLR8; TNFAIP3; TNFRSF13B; TNFRSF13C; TNFRSF17; TNFRSF1B; TNFSF13B; TNFSF18; TRAT1; TXK; WAS; XCL1; ZAP70; ZNF683
GO:0032620	interleukin-17 production	6.56	1.68e-07	2.79e-06	11/23	VSIR; FOXP3; IFNG; IL12B; IL18; IL21; LY9; NCKAP1L; PRKCQ; RFTN1; SLAMF6
GO:0098760	response to interleukin-7	6.33	1.61e-04	1.79e-03	6/13	BTK; IL2RG; IL7R; IL7; JAK3; SOCS1
GO:0042113	B cell activation	6.23	0.00e+00	0.00e+00	59/130	BANK1; BTK; CARD11; CCR6; CD22; CD27; CD28; CD38; CD40LG; CD40; CD74; CD79A; CD79B; CR2; CTLA4; CXCR5; DOCK11; FCRL1; FCRL3; FLT3; FOXP3; GAPT; GPR183; IGLL1; IKZF3; IL21; IL7R; IL7; INPP5D; ITGA4; ITM2A; JAK3; LAX1; LYL1; MFNG; MZB1; MS4A1; NCKAP1L; PIK3CD; PLCG2; PLCL2; POU2F2; PRKCB; PTK2B; PTPRC; SAMSN1; SASH3; SLA2; SLAMF8; SYK; TBC1D10C; TBX21; TNFAIP3; TNFRSF13B; TNFRSF13C; TNFRSF4; TNFSF13B; VCAM1; ZAP70
GO:0002449	lymphocyte mediated immunity	6.08	0.00e+00	0.00e+00	70/158	B2M; BTK; BTN3A2; BTN3A3; C1QA; C1S; C3; C7; CCR6; CD1A; CD1B; CD1C; CD1D; CD1E; CD226; CD27; CD28; CD40LG; CD40; CD74; CD8A; CD96; CORO1A; CR1; CR2; CRTAM; FCER2; FOXP3; GAPT; GZMB; GZMM; HLA-DQB1; HLA-E; HLA-F; IGLL1; IL12B; IL18R1; IL18RAP; IL18; IL21; IL7R; INPP5D; KIR2DL4; KIR3DL1; KLRC2; KLRK1; LAG3; LILRB1; LTA; MYO1G; NCR1; NCR3; POU2F2; PRF1; PTPRC; RFTN1; SASH3; SERPINB9; SH2D1A; SH2D1B; SLA2; SLAMF6; SLAMF7; SLC11A1; TBX21; TLR8; TNFRSF1B; VAV1; WAS; XCL1
GO:0032615	interleukin-12 production	6.05	3.63e-09	7.21e-08	15/34	CCL19; CCR7; CD40LG; CD40; IDO1; IFNG; IL12B; IRF1; IRF8; JAK3; LILRB1; LTB; SLAMF1; TIGIT; TLR8
GO:0030101	natural killer cell activation	5.97	1.18e-11	2.83e-10	20/46	CD244; CD2; CORO1A; FLT3LG; HLA-E; IL12B; IL18R1; IL18; IL21R; ITGB2; KLRK1; NCR1; NCR3; PIK3CD; PRDM1; PTPN22; PTPRC; SLAMF7; TOX; ZNF683
GO:0045730	respiratory burst	5.97	1.87e-06	2.58e-05	10/23	CD52; CYBB; JCHAIN; NCF1; NCF4; PIK3CD; PIK3CG; RAC2; SLAMF8; SLC11A1
GO:0032609	interferon-gamma production	5.93	0.00e+00	0.00e+00	38/88	BTN3A1; BTN3A2; VSIR; CCR2; CCR7; CD226; CD244; CD274; CD2; CD3E; CD96; EBI3; EOMES; FOXP3; HLA-DPA1; HLA-DPB1; IL12B; IL12RB2; IL18R1; IL18RAP; IL18; IL21; IL33; IRF8; ITK; KLRK1; LILRB1; LTA; PDCD1LG2; PTPN22; SASH3; SLAMF6; SLC11A1; SPN; TLR8; TNFRSF13C; TXK; XCL1
GO:0031579	membrane raft organization	5.72	1.04e-03	1.01e-02	5/12	CD2; DOCK2; MAL; PTPRC; RFTN1
GO:0070661	leukocyte proliferation	5.65	0.00e+00	0.00e+00	82/199	AIF1; BTK; BTN3A1; VSIR; CARD11; CCDC88B; CCL19; CCL5; CCR2; CD1D; CD22; CD274; CD28; CD38; CD3E; CD40LG; CD40; CD4; CD6; CD74; CD79A; CLECL1; CORO1A; CR2; CRTAM; CTLA4; DOCK2; DOCK8; EBI3; FCRL3; FLT3LG; FLT3; FOXP3; FYN; GAPT; GPR183; HLA-DMB; HLA-DPA1; HLA-DPB1; HLA-E; IDO1; IKZF3; IL12B; IL18; IL21; IL2RA; IL33; IL7R; IL7; INPP5D; IRF1; JAK3; LILRB1; LST1; MZB1; MS4A1; NCKAP1L; PDCD1LG2; PIK3CG; PLA2G2D; PLCL2; PRKCQ; PSMB10; PTPN22; PTPRC; RAC2; RASAL3; SASH3; SLC11A1; SPN; SYK; TNFAIP3; TNFRSF13B; TNFRSF13C; TNFRSF14; TNFRSF1B; TNFRSF4; TNFSF13B; TNFSF18; VCAM1; XCL1; ZAP70
GO:0001562	response to protozoan	5.65	1.07e-04	1.24e-03	7/17	CCDC88B; CD40; IL12B; IRF4; IRF8; SLC11A1; TSPAN32
GO:0042110	T cell activation	5.58	0.00e+00	0.00e+00	126/310	AIF1; JAML; APBB1IP; B2M; BCL11B; BTLA; BTN3A1; VSIR; CAMK4; CARD11; CCDC88B; CCL19; CCL21; CCL5; CCR2; CCR6; CCR7; CD1C; CD1D; CD274; CD27; CD28; CD2; CD3D; CD3E; CD3G; CD40LG; CD4; CD5; CD6; CD74; CD7; CD8A; CD8B; CLEC4A; CLECL1; CORO1A; CR1; CRTAM; CTLA4; DOCK2; DOCK8; EBI3; EOMES; RIPOR2; FOXP3; FUT7; FYN; GPR183; GPR18; GRAP2; HLA-DMB; HLA-DOA; HLA-DPA1; HLA-DPB1; HLA-E; ICOS; IDO1; IFNG; IL12B; IL18R1; IL18; IL21; IL2RA; IL7R; IL7; IRF1; IRF4; ITGAL; ITK; JAK3; TESPA1; KLRK1; LAG3; LAT; LAX1; LCK; LCP1; LILRB1; LY9; NCKAP1L; PAG1; PDCD1LG2; PDCD1; PIK3CD; PIK3CG; PLA2G2D; PRDM1; PRKCQ; PSMB10; PTGER4; PTPN22; PTPRC; RAC2; RASAL3; RHOH; RUNX3; SASH3; SIRPG; SIT1; SLA2; SLAMF6; SLC11A1; SOCS1; SPN; SYK; TBX21; TCF7; THEMIS; TIGIT; TNFAIP8L2; TNFRSF13C; TNFRSF14; TNFRSF1B; TNFRSF4; TNFSF13B; TNFSF18; TNFSF8; TREML2; VAV1; VCAM1; WAS; WNT1; XCL1; ZAP70; ZNF683
GO:0032623	interleukin-2 production	5.37	1.05e-09	2.13e-08	18/46	CARD11; CCR2; CD247; CD28; CD3E; CD4; FOXP3; GBP1; IL18; IRF4; LAG3; PRKCQ; PTPRC; SASH3; SLC11A1; TBX21; TNFAIP3; XCL1
GO:0032613	interleukin-10 production	5.34	8.55e-08	1.48e-06	14/36	VSIR; CD274; CD28; CD40LG; FOXP3; IDO1; IL12B; IRF4; JAK3; LILRB1; PDCD1LG2; SASH3; TIGIT; XCL1
GO:0002285	lymphocyte activation involved in immune response	5.32	0.00e+00	0.00e+00	38/98	APBB1IP; CCL19; CCR6; CD1C; CD244; CD28; CD40LG; CD40; CORO1A; DOCK11; EOMES; FOXP3; GAPT; GPR183; HLA-DMB; IFNG; IL12B; IL18R1; IL18; IRF4; ITGAL; ITM2A; JAK3; LCP1; LILRB1; LY9; MFNG; PLCG2; PLCL2; PTGER4; PTK2B; PTPRC; SLAMF6; SLC11A1; SPN; TBX21; TNFSF18; ZNF683
GO:0032633	interleukin-4 production	5.31	7.76e-07	1.11e-05	12/31	CD28; CD3E; CD40LG; CLECL1; FOXP3; HLA-E; IL33; IRF4; ITK; PRKCQ; SASH3; SYK
GO:0019882	antigen processing and presentation	5.30	0.00e+00	0.00e+00	34/88	B2M; CCL19; CCL21; CCR7; CD1A; CD1B; CD1C; CD1D; CD1E; CD74; CD8A; CLEC4A; CTSS; HLA-DMB; HLA-DOA; HLA-DOB; HLA-DPA1; HLA-DPB1; HLA-DQA1; HLA-DQA1; HLA-DQA2; HLA-DQB1; HLA-DQB2; HLA-DRA; HLA-DRB1; HLA-DRB5; HLA-E; HLA-F; LAG3; RAB33A; RFTN1; SLC11A1; TAP1; TAP2; WAS
GO:0001906	cell killing	5.21	0.00e+00	0.00e+00	41/108	APOL1; B2M; CCL13; CD1A; CD1B; CD1C; CD1D; CD1E; CD226; CORO1A; CRTAM; DNASE1L3; FCER2; GNLY; GZMB; GZMM; HLA-E; HLA-F; IFNG; IL12B; IL18RAP; IL18; IL21; IL7R; KIR2DL4; KIR3DL1; KLRK1; LAG3; LILRB1; LYZ; NCR1; NCR3; PRF1; PTPRC; SERPINB9; SH2D1A; SLAMF6; SLAMF7; STAP1; VAV1; XCL1
GO:0007159	leukocyte cell-cell adhesion	5.20	0.00e+00	0.00e+00	88/232	AIF1; BTLA; VSIR; CARD11; CCDC88B; CCL19; CCL21; CCL25; CCL5; CCR2; CCR7; CD1D; CD274; CD27; CD28; CD3E; CD40LG; CD4; CD5; CD6; CD74; CLECL1; CORO1A; CTLA4; DOCK8; EBI3; ETS1; RIPOR2; FERMT3; FOXP3; FYN; GRAP2; HLA-DMB; HLA-DPA1; HLA-DPB1; HLA-E; ICOS; IDO1; IFNG; IL12B; IL18; IL21; IL2RA; IL7R; IL7; IRF1; ITGA4; ITGAL; ITGB2; ITGB7; JAK3; TESPA1; KLRK1; LAG3; LAX1; LCK; LILRB1; NCKAP1L; PAG1; PDCD1LG2; PDCD1; PLA2G2D; PRKCQ; PTAFR; PTPN22; PTPRC; RAC2; RASAL3; RUNX3; SASH3; SELE; SELL; SELPLG; SELP; SIRPG; SOCS1; SPN; SYK; TBX21; TIGIT; TNFAIP8L2; TNFRSF13C; TNFRSF14; TNFSF13B; VAV1; VCAM1; XCL1; ZAP70
GO:0002347	response to tumor cell	5.15	6.20e-04	6.31e-03	6/16	CD226; CD274; CRTAM; IL12B; KLRK1; PRF1
GO:0050867	positive regulation of cell activation	5.14	0.00e+00	0.00e+00	82/219	AIF1; BTK; BTLA; VSIR; CARD11; CCDC88B; CCL19; CCL21; CCL5; CCR2; CCR7; CD1D; CD226; CD274; CD27; CD28; CD2; CD38; CD3E; CD40LG; CD40; CD4; CD5; CD6; CD74; CLECL1; CORO1A; CTLA4; DOCK8; EBI3; FCRL3; FLT3LG; FOXP3; FYN; GPR183; GRAP2; HLA-DMB; HLA-DPA1; HLA-DPB1; HLA-E; ICOS; IFNG; IGLL1; IL12B; IL18; IL21; IL2RA; IL33; IL7R; IL7; INPP5D; ITGB2; JAK3; TESPA1; KLRK1; LCK; LILRB1; NCKAP1L; PDCD1LG2; PDCD1; PLEK; PRKCQ; PTAFR; PTPRC; RASAL3; RUNX3; SASH3; SELP; SIRPG; SOCS1; STAP1; SYK; TBX21; TNFRSF13C; TNFRSF14; TNFRSF4; TNFSF13B; TOX; VAV1; VCAM1; XCL1; ZAP70
GO:0042107	cytokine metabolic process	4.89	2.48e-12	6.51e-11	26/73	CARD11; CCR2; CD28; CD3E; CD4; CYBB; EBI3; FOXP3; GHRL; IL12B; IL18; IL21; INPP5D; IRF1; IRF4; LAG3; LILRB1; LTB; PRKCQ; PTAFR; PTPRC; SPN; SYK; TLR8; TNFRSF13C; TNFRSF8
GO:0033622	integrin activation	4.84	8.99e-04	8.93e-03	6/17	CXCL13; FERMT3; MZB1; PLEK; PTGER4; SELP
GO:0002694	regulation of leukocyte activation	4.74	0.00e+00	0.00e+00	116/336	AIF1; BANK1; BTK; BTLA; VSIR; CAMK4; CARD11; CCDC88B; CCL19; CCL21; CCL5; CCR2; CCR7; CD1D; CD226; CD22; CD274; CD27; CD28; CD2; CD300LF; CD38; CD3E; CD40LG; CD40; CD4; CD5; CD6; CD74; CLECL1; CNR2; CORO1A; CR1; CTLA4; DOCK8; EBI3; RIPOR2; FCRL3; FLT3LG; FOXP3; FYN; GPR183; GRAP2; HLA-DMB; HLA-DOA; HLA-DPA1; HLA-DPB1; HLA-E; ICOS; IDO1; IFNG; IGLL1; IKZF3; IL12B; IL18; IL21; IL2RA; IL33; IL7R; IL7; INPP5D; IRF1; IRF4; ITGB2; JAK3; TESPA1; KLRK1; LAG3; LAT; LAX1; LCK; LILRB1; LST1; MZB1; NCKAP1L; PAG1; PDCD1LG2; PDCD1; PLA2G2D; PRDM1; PRKCQ; PTAFR; PTPN22; PTPRC; RAC2; RASAL3; RUNX3; SAMSN1; SASH3; SIRPG; SIT1; SLA2; SLAMF8; SOCS1; SPN; STAP1; SYK; TBC1D10C; TBX21; TIGIT; TNFAIP3; TNFAIP8L2; TNFRSF13B; TNFRSF13C; TNFRSF14; TNFRSF1B; TNFRSF4; TNFSF13B; TNFSF18; TOX; TSPAN32; VAV1; VCAM1; XCL1; ZAP70; ZNF683
GO:0002437	inflammatory response to antigenic stimulus	4.73	2.19e-05	2.83e-04	10/29	BTK; C3; CCR7; CD28; CD6; HLA-E; IL12B; IL2RA; IL5RA; LTA
GO:0019835	cytolysis	4.73	2.19e-05	2.83e-04	10/29	APOL1; C7; CFHR1; GZMA; GZMB; GZMH; GZMM; LILRB1; LYZ; PRF1
GO:0034341	response to interferon-gamma	4.68	0.00e+00	0.00e+00	44/129	AIF1; B2M; CASP1; CCL13; CCL17; CCL19; CCL21; CCL22; CCL25; CCL5; CD40; CIITA; GBP1; GBP2; GBP4; GBP5; HLA-DPA1; HLA-DPB1; HLA-DQA1; HLA-DQA1; HLA-DQA2; HLA-DQB1; HLA-DQB2; HLA-DRA; HLA-DRB1; HLA-DRB5; HLA-E; HLA-F; IFNG; IL12B; IRF1; IRF4; IRF8; NLRC5; PTAFR; SLC11A1; SOCS1; STAT1; TRIM22; TXK; UBD; VCAM1; WAS; XCL1; XCL2
GO:0071887	leukocyte apoptotic process	4.64	1.56e-10	3.44e-09	23/68	BTK; CCL19; CCL21; CCL5; CCR5; CCR7; CD274; CD27; CD3G; CD74; DOCK8; FASLG; GIMAP8; HCLS1; IDO1; IL2RA; IL7R; JAK3; LILRB1; PDCD1; PIK3CD; PRKCQ; TNFRSF4
GO:0002764	immune response-regulating signaling pathway	4.64	0.00e+00	0.00e+00	98/290	BIRC3; BLK; BTK; BTLA; BTN1A1; BTN3A1; BTN3A2; BTN3A3; C5AR1; CARD11; CCR7; CD19; CD200R1; CD226; CD22; CD247; CD28; CD300LF; CD38; CD3D; CD3E; CD3G; CD40; CD4; CD79A; CD79B; CLEC10A; CLEC4A; CLEC4C; CLEC6A; CR1; CR2; CTLA4; CTSS; FCN1; FCRL3; FOXP3; FYB1; FYN; GBP1; GCSAM; GFI1; GRAP2; HLA-DPA1; HLA-DPB1; HLA-DQA1; HLA-DQA1; HLA-DQA2; HLA-DQB1; HLA-DQB2; HLA-DRA; HLA-DRB1; HLA-DRB5; ICAM3; IGLL1; INPP5D; IRF1; IRF4; ITGB2; ITK; TESPA1; KIR2DL1; KLHL6; KLRK1; LAT; LCK; LCP2; LILRA4; LILRB1; LIME1; LPXN; MYO1G; NCKAP1L; NCR3; PAG1; PAX5; PIK3CD; PLCG2; PLCL2; PRKCB; PRKCQ; PTPN22; PTPRC; PVRIG; RFTN1; SLA2; STAP1; SYK; THEMIS; TLR8; TNFAIP3; TNIP3; TRAT1; TXK; UBASH3A; VAV1; WAS; WIPF1; ZAP70
GO:0002440	production of molecular mediator of immune response	4.61	0.00e+00	0.00e+00	40/119	B2M; BTK; CAMK4; CARD11; CCR6; CD226; CD22; CD244; CD28; CD40LG; CD40; CD74; CD96; FCRL3; FOXP3; GAPT; HLA-DQB1; HLA-E; IL12B; IL18R1; IL18RAP; IL18; IL33; IL7R; ITM2A; JAK3; KIR2DL4; LILRB1; MZB1; POU2F2; PTPRC; SASH3; SLC11A1; TBX21; TNFRSF14; TNFRSF1B; TNFRSF4; TNFSF13B; VPREB3; XCL1
GO:1990868	response to chemokine	4.57	5.71e-12	1.41e-10	27/81	CCL13; CCL17; CCL19; CCL21; CCL22; CCL25; CCL5; CCR2; CCR4; CCR5; CCR6; CCR7; CCR8; CXCL10; CXCL11; CXCL13; CXCL9; CXCR3; CXCR5; CXCR6; ACKR1; DOCK8; RIPOR2; PTK2B; XCL1; XCL2; XCR1
GO:0002697	regulation of immune effector process	4.50	0.00e+00	0.00e+00	81/247	AIM2; APOBEC3F; APOBEC3G; B2M; BIRC3; BTK; C1QA; C1S; C3; C5AR1; C7; CCL19; CCR2; CD19; CD1A; CD1B; CD1C; CD1D; CD1E; CD226; CD22; CD244; CD28; CD40LG; CD40; CD74; CD96; CFHR1; CFH; CFP; CR1; CR2; CRTAM; DNASE1L3; FCER2; FCRL3; FOXP3; HLA-DMB; HLA-E; HLA-F; IFNG; IL12B; IL18R1; IL18RAP; IL18; IL21; IL2RA; IL33; IL7R; IRF4; ITGB2; JAK3; KIR2DL4; KLRK1; LAG3; LILRB1; LTA; MZB1; NCR1; NCR3; PTAFR; PTPRC; RAC2; SASH3; SERPINB9; SH2D1A; SH2D1B; SLAMF6; SLAMF8; STAT1; SYK; TBX21; TNFAIP3; TNFRSF14; TNFRSF1B; TNFRSF4; TSPAN32; VAV1; WAS; XCL1; ZNF683
GO:0002200	somatic diversification of immune receptors	4.41	1.07e-04	1.24e-03	9/28	BCL11B; CCR6; CD28; CD40LG; CD40; FOXP3; PTPRC; TBX21; TCF7
GO:0050866	negative regulation of cell activation	4.15	4.00e-15	1.25e-13	39/129	BANK1; BTK; VSIR; CCR2; CD274; CD300LF; CD74; CNR2; CTLA4; RIPOR2; FOXP3; IDO1; IL2RA; INPP5D; IRF1; JAK3; LAG3; LAX1; LILRB1; LST1; PAG1; PDCD1LG2; PLA2G2D; PTPN22; PTPRC; RUNX3; SAMSN1; SLA2; SOCS1; SPN; TBC1D10C; TBX21; TIGIT; TNFAIP3; TNFAIP8L2; TNFRSF13B; TNFRSF14; TSPAN32; XCL1
GO:0022407	regulation of cell-cell adhesion	4.03	0.00e+00	0.00e+00	82/279	AIF1; BTLA; VSIR; CARD11; CCDC88B; CCL19; CCL21; CCL25; CCL5; CCR2; CCR7; CD1D; CD274; CD27; CD28; CD3E; CD40LG; CD4; CD5; CD6; CD74; CLECL1; CORO1A; CTLA4; CXCL13; DOCK8; EBI3; ETS1; RIPOR2; FERMT3; FOXP3; FYN; GRAP2; HLA-DMB; HLA-DPA1; HLA-DPB1; HLA-E; ICOS; IDO1; IFNG; IL12B; IL18; IL21; IL2RA; IL7R; IL7; IRF1; ITGA4; JAK3; TESPA1; KLRK1; LAG3; LAX1; LCK; LILRB1; NCKAP1L; PAG1; PDCD1LG2; PDCD1; PLA2G2D; PRKCQ; PTAFR; PTPN22; PTPRC; RASAL3; RUNX3; SASH3; SIRPG; SOCS1; SPN; SYK; TBX21; TIGIT; TNFAIP8L2; TNFRSF13C; TNFRSF14; TNFSF13B; VAV1; VCAM1; WNT1; XCL1; ZAP70
GO:0002521	leukocyte differentiation	4.03	0.00e+00	0.00e+00	94/320	B2M; BATF3; BCL11B; BTK; VSIR; CAMK4; CARD11; CCL19; CCR6; CCR7; CD1D; CD27; CD28; CD2; CD3D; CD3E; CD3G; CD40LG; CD4; CD74; CD79A; CD79B; CD8A; CR1; CR2; CTLA4; DOCK11; DOCK2; EOMES; EVI2B; FCRL3; FLT3LG; FLT3; FOXP3; FUT7; GAB3; GPR183; GPR18; GPR55; HCLS1; HLA-DOA; IFNG; IKZF1; IKZF3; IL12B; IL18R1; IL18; IL2RA; IL7R; IL7; INPP5D; IRF1; IRF4; ITGA4; ITK; ITM2A; JAK3; TESPA1; LCK; LILRB1; LY9; LYL1; MFNG; NCKAP1L; PIK3CD; PLA2G2D; PLCG2; PLCL2; POU2F2; PRDM1; PTGER4; PTK2B; PTPN22; PTPRC; RASSF2; RHOH; RUNX3; SASH3; SLAMF6; SLAMF8; SOCS1; SPN; SYK; TBX21; TCF7; THEMIS; TNFSF8; TOX; UBD; VAV1; VCAM1; WNT1; ZAP70; ZNF683
GO:0001819	positive regulation of cytokine production	3.74	0.00e+00	0.00e+00	75/275	AIM2; B2M; BIRC3; C3; C5AR1; CARD11; CASP1; CCDC88B; CCL19; CCR2; CCR7; CD226; CD244; CD274; CD28; CD2; CD3E; CD40LG; CD40; CD4; CD6; CD74; CLEC5A; CLEC6A; CLEC9A; CRTAM; CYBB; EBI3; FCN1; FOXP3; GBP5; GPSM3; HLA-DPA1; HLA-DPB1; HLA-E; IDO1; IFNG; IL12B; IL12RB2; IL18R1; IL18; IL21; IL33; IL7; IRF1; IRF4; IRF8; KIR2DL4; KLRK1; LILRB1; LOC728392; LTA; LTB; LY9; MCOLN2; NLRP1; PLCG2; PRKCQ; PTAFR; PTGER4; PTPN22; PTPRC; SASH3; SLAMF6; SLC11A1; SPN; STAT1; SYK; TIGIT; TLR8; TNFRSF13C; TNFRSF14; TNFRSF8; TXK; XCL1; ZBP1
GO:0070670	response to interleukin-4	3.74	3.96e-03	3.29e-02	6/22	CD300LF; CORO1A; IL2RG; JAK3; TCF7; XCL1
GO:0042092	type 2 immune response	3.69	2.03e-03	1.86e-02	7/26	CCR2; CD74; IDO1; IL18; IL33; TBX21; XCL1
GO:0002683	negative regulation of immune system process	3.58	0.00e+00	0.00e+00	73/280	BANK1; BTK; VSIR; CCL21; CCL25; CCR2; CD200R1; CD22; CD274; CD300LF; CD74; CD96; CNR2; CR1; CTLA4; RIPOR2; FCRL3; FOXP3; GBP1; GCSAM; GPR171; GPR18; GPR55; HLA-DOA; HLA-DOB; HLA-E; IDO1; IL12B; IL2RA; IL33; IL7R; INPP5D; IRF1; IRF4; JAK3; KIR2DL4; KLRK1; LAG3; LAX1; LILRA4; LILRB1; LPXN; LST1; NLRC5; PAG1; PDCD1LG2; PDCD1; PLA2G2D; PLCL2; PTGER4; PTK2B; PTPN22; PTPRC; PVRIG; RUNX3; SAMSN1; SERPINB9; SLA2; SLAMF8; SOCS1; SPN; STAP1; TBC1D10C; TBX21; TIGIT; TNFAIP3; TNFAIP8L2; TNFRSF13B; TNFRSF14; TNFRSF4; TSPAN32; UBASH3A; XCL1
GO:0034612	response to tumor necrosis factor	3.56	2.43e-13	7.02e-12	41/158	AIM2; BIRC3; CARD16; CASP1; CCL13; CCL17; CCL19; CCL21; CCL22; CCL25; CCL5; CD27; CD40LG; CD40; CD70; GBP1; GBP2; LTA; LTB; PTK2B; SELE; STAT1; SYK; TCL1A; TNFAIP3; TNFRSF13B; TNFRSF13C; TNFRSF14; TNFRSF17; TNFRSF1B; TNFRSF4; TNFRSF8; TNFRSF9; TNFSF13B; TNFSF18; TNFSF8; TRAF1; UBD; VCAM1; XCL1; XCL2
GO:0035587	purinergic receptor signaling pathway	3.56	2.58e-03	2.31e-02	7/27	GPR171; P2RX1; P2RY10; P2RY13; P2RY14; P2RY8; PTAFR
GO:0045785	positive regulation of cell adhesion	3.55	0.00e+00	0.00e+00	74/286	ABI3BP; AIF1; APBB1IP; BTLA; VSIR; CARD11; CASS4; CCDC88B; CCL19; CCL21; CCL25; CCL5; CCR2; CCR7; CD1D; CD274; CD27; CD28; CD3E; CD40LG; CD4; CD5; CD6; CD74; CLECL1; CORO1A; CTLA4; CXCL13; DOCK8; EBI3; ETS1; FOXP3; FYN; GRAP2; HLA-DMB; HLA-DPA1; HLA-DPB1; HLA-E; ICOS; IFNG; IL12B; IL18; IL21; IL2RA; IL7R; IL7; ITGA4; JAK3; TESPA1; KLRK1; LCK; LILRB1; NCKAP1L; PDCD1LG2; PDCD1; PRKCQ; PTAFR; PTK2B; PTPRC; RASAL3; RUNX3; SASH3; SIRPG; SOCS1; SPOCK2; SYK; TNFRSF13C; TNFRSF14; TNFSF13B; TNFSF18; VAV1; VCAM1; XCL1; ZAP70
GO:0050663	cytokine secretion	3.52	1.41e-12	3.83e-11	39/152	AIM2; BANK1; BTN3A1; BTN3A2; CARD11; CARD16; CARD17; CASP1; CCL19; CCR7; CD200R1; CD244; CD274; CD2; CLEC5A; CLEC6A; CLEC9A; CLECL1; CRTAM; FCN1; FOXP3; GBP1; GBP5; GHRL; IL33; LCP2; LILRB1; LOC728392; MCOLN2; NLRP1; PTGER4; PTPN22; SOCS1; SRGN; SYK; TLR8; TNFAIP3; TNFRSF14; TNFRSF1B; TNFRSF4
GO:0045088	regulation of innate immune response	3.48	0.00e+00	0.00e+00	56/221	AIM2; BIRC3; BTK; CARD11; CCL5; CD1D; CD226; CD300LF; CD96; CLEC10A; CLEC4A; CLEC4C; CLEC6A; CR1; CRTAM; CTSS; FCN1; FCRL3; FYN; GBP5; GFI1; HLA-E; ICAM3; IFNG; IL12B; IL18RAP; IL21; IRF1; IRF4; ITGB2; KIR2DL4; KLRK1; LAG3; LILRA4; LILRB1; NCR1; NCR3; NLRC5; PLCG2; PTPN22; PYHIN1; RFTN1; SERPINB9; SH2D1A; SH2D1B; SLAMF6; SLAMF8; SOCS1; STAT1; SYK; TLR8; TNFAIP3; TNIP3; TXK; VAV1; ZBP1
GO:0032606	type I interferon production	3.43	2.33e-04	2.56e-03	11/44	IRF1; LILRA4; LILRB1; NLRC5; PLCG2; PTPN22; STAT1; SYK; TLR8; TNFAIP3; ZBP1
GO:0048872	homeostasis of number of cells	3.41	5.70e-11	1.29e-09	35/141	B2M; CARD11; CCR2; CCR4; CCR7; CD74; CORO1A; DOCK11; ETS1; FLT3LG; FLT3; FOXP3; GAPT; GPR174; GPR183; HCLS1; IKZF1; IL2RA; IL7R; IL7; INPP5D; JAK3; LAT; NCKAP1L; PIK3CD; RASSF2; SASH3; SIT1; STAT1; TNFAIP3; TNFRSF13B; TNFRSF13C; TNFRSF17; TNFRSF4; TNFSF13B
GO:0050900	leukocyte migration	3.40	0.00e+00	0.00e+00	79/319	AIF1; JAML; ANGPT2; C5AR1; CCL13; CCL17; CCL19; CCL21; CCL22; CCL25; CCL5; CCR2; CCR5; CCR6; CCR7; CD200R1; CD244; CD2; CD48; CD74; CNR2; CORO1A; CXCL10; CXCL11; CXCL13; CXCL9; CXCR3; CXCR5; DBH; DOCK8; DOK2; RIPOR2; FCAMR; FUT7; FYN; GCSAM; GPR15; GPR183; GPR18; GPSM3; JCHAIN; IGLL1; IL16; IL33; INPP5D; ITGA4; ITGAL; ITGB2; ITGB7; KLRK1; LCK; MCOLN2; MYO1G; NCKAP1L; PIK3CD; PIK3CG; PTAFR; PTGER4; PTK2B; RAC2; SELE; SELL; SELPLG; SELP; SIRPG; SLAMF8; SPN; STAP1; SYK; TBX21; TNFRSF14; TNFSF18; TREM1; VAV1; VCAM1; VPREB3; XCL1; XCL2; ZAP70
GO:0006959	humoral immune response	3.37	2.50e-13	7.02e-12	44/179	C1QA; C1S; C3; C5AR1; C7; CCL13; CCR2; CCR6; CCR7; CD19; CD28; CFHR1; CFH; CFP; CR1; CR2; CXCL10; CXCL11; CXCL13; CXCL9; EBI3; FCER2; FCN1; GNLY; GPR183; HLA-DQB1; HLA-E; IFNG; JCHAIN; IGLL1; IL7; LTA; LYZ; MS4A1; PAX5; PDCD1; POU2AF1; POU2F2; PSMB10; PTPRC; RNASE6; SH2D1A; SLC11A1; TREM1
GO:0002532	production of molecular mediator involved in inflammatory response	3.35	5.53e-04	5.69e-03	10/41	ABCD2; BTK; CD6; CD96; GBP5; GPSM3; IDO1; P2RX1; SLAMF8; SYK
GO:0045576	mast cell activation	3.28	3.54e-04	3.75e-03	11/46	BTK; CD226; CD300LF; CNR2; LAT; LCP2; PIK3CD; PIK3CG; RAC2; RHOH; SYK
GO:0010324	membrane invagination	3.23	2.52e-03	2.28e-02	8/34	AIF1; ARHGAP25; BIN2; C3; IGLL1; ITGB2; NCKAP1L; STAP1
GO:0071706	tumor necrosis factor superfamily cytokine production	3.22	3.58e-07	5.61e-06	23/98	VSIR; CCL19; CCR2; CD274; CD2; CLEC4A; CYBB; FOXP3; GHRL; GPR18; HLA-E; IFNG; IL12B; LILRA4; LILRB1; PTAFR; PTPN22; PTPRC; SASH3; SLAMF1; SPN; TNFAIP3; TNFRSF8
GO:1903706	regulation of hemopoiesis	3.09	3.62e-14	1.09e-12	53/235	B2M; BTK; VSIR; CAMK4; CARD11; CCL19; CD27; CD28; CD2; CD4; CD74; CR1; CTLA4; ETS1; EVI2B; FCRL3; FLT3LG; FOXP3; GP1BA; GPR171; GPR55; HCLS1; HLA-DOA; IFNG; IKZF3; IL12B; IL18; IL2RA; IL7R; IL7; INPP5D; IRF1; IRF4; JAK3; TESPA1; LILRB1; NCKAP1L; PRDM1; PRKCB; PRKCQ; PTK2B; PTPRC; RASSF2; RUNX3; SASH3; SLAMF8; SOCS1; STAT1; SYK; TBX21; TOX; ZAP70; ZNF683
GO:0001818	negative regulation of cytokine production	3.03	3.41e-10	7.31e-09	38/172	ABCD2; BANK1; BTK; VSIR; CARD16; CARD17; CD200R1; CD274; CD96; CLEC4A; FOXP3; GBP1; GHRL; GPR18; IDO1; IFNG; IL12B; IL33; INPP5D; JAK3; LAG3; LILRA4; LILRB1; NCKAP1L; NLRC5; PDCD1LG2; PTGER4; PTPN22; PTPRC; SLAMF1; SLC11A1; SRGN; TBX21; TIGIT; TLR8; TNFAIP3; TNFRSF4; XCL1
GO:0031349	positive regulation of defense response	3.03	6.66e-16	2.17e-14	62/281	AIM2; BIRC3; BTK; C3; CARD11; CCL5; CCR2; CCR7; CD1D; CD226; CD28; CD300LF; CD6; CLEC10A; CLEC4A; CLEC4C; CLEC6A; CREB3L3; CRTAM; CTSS; ETS1; FCN1; FCRL3; FYN; GBP5; GFI1; GPSM3; HLA-E; ICAM3; IDO1; IL12B; IL18RAP; IL18; IL21; IL33; IRF1; IRF4; ITGB2; KIR2DL4; KLRK1; LAG3; LILRA4; LTA; NCR3; NLRC5; PIK3CG; PLCG2; PTGER4; PTPN22; PYHIN1; RFTN1; SH2D1A; SH2D1B; SLAMF6; STAP1; SYK; TLR8; TNFAIP3; TNIP3; TXK; VAV1; ZBP1
GO:0002831	regulation of response to biotic stimulus	3.03	8.50e-05	1.02e-03	15/68	AIM2; APOBEC3F; APOBEC3G; BIRC3; CARD16; CD226; CD274; CRTAM; IL12B; IL2RA; KLRK1; LILRB1; STAT1; TNFAIP3; TSPAN32
GO:0060326	cell chemotaxis	2.94	4.65e-12	1.18e-10	48/224	AIF1; JAML; BIN2; C5AR1; CCL13; CCL17; CCL19; CCL21; CCL22; CCL25; CCL5; CCR2; CCR4; CCR5; CCR6; CCR7; CCR8; CD74; CNR2; CORO1A; CXCL10; CXCL11; CXCL13; CXCL9; CXCR3; CXCR5; CXCR6; RIPOR2; GPR183; GPR18; GPSM3; IL16; ITGB2; KLRK1; NCKAP1L; PIK3CD; PIK3CG; PRKCQ; PTK2B; RAC2; SLAMF8; STAP1; SYK; VAV1; VCAM1; XCL1; XCL2; XCR1
GO:0033627	cell adhesion mediated by integrin	2.90	1.08e-03	1.02e-02	11/52	CCL21; CCL5; CD3E; CXCL13; FERMT3; ITGB2; ITGB7; LPXN; NCKAP1L; PIK3CG; SYK
GO:0007249	I-kappaB kinase/NF-kappaB signaling	2.87	4.20e-07	6.34e-06	27/129	APOL3; BIRC3; BTK; CARD11; CARD16; CASP10; CASP1; CCL19; CCL21; CCR7; CD40; CD4; CD74; CLEC6A; FASLG; FYN; LIME1; PIM2; PRKCB; RHOH; STAT1; TIFAB; TLR8; TNFAIP3; TNIP3; TRIM22; UBD
GO:0150076	neuroinflammatory response	2.87	3.26e-03	2.85e-02	9/43	AIF1; CD200R1; IL18; IL33; ITGB2; PTPRC; STAP1; TLR8; TNFRSF1B
GO:0006909	phagocytosis	2.86	1.06e-07	1.80e-06	30/144	AIF1; ARHGAP25; BIN2; C3; CD247; CD300LF; CD3G; CORO1A; DOCK2; FCN1; FYN; ICAM3; IGLL1; IRF8; ITGAL; ITGB2; MYO1G; NCF4; NCKAP1L; PLCG2; PLD4; PTPRC; SIRPG; SLAMF1; SLC11A1; STAP1; SYK; VAV1; WAS; WIPF1
GO:0060759	regulation of response to cytokine stimulus	2.83	2.68e-05	3.36e-04	19/92	BIRC3; CARD16; CASP1; CCL5; CD300LF; CD74; GFI1; IFNG; IL7; NLRC5; PTPRC; SOCS1; STAP1; STAT1; SYK; TNFAIP3; TRAF1; TXK; ZBP1
GO:0009615	response to virus	2.80	4.30e-08	7.78e-07	33/162	AIM2; APOBEC3C; APOBEC3F; APOBEC3G; APOBEC3H; BATF3; BIRC3; CCL19; CCL22; CCL5; CD40; CXCL10; CXCL9; FOXP3; GBP1; IFNG; IL12B; IL2RA; IL33; IRF1; LILRB1; NLRC5; PIM2; PRF1; PTPRC; RNASE6; STAT1; TBX21; TLR8; TNFAIP3; TRIM22; TSPAN32; XCL1
GO:0072376	protein activation cascade	2.74	4.31e-04	4.50e-03	14/70	C1QA; C1S; C3; C5AR1; C7; CD19; CFHR1; CFH; CFP; CR1; CR2; FCN1; GP1BA; IGLL1
GO:0097696	STAT cascade	2.74	1.08e-04	1.24e-03	17/85	CCL5; CCR2; CD40; FLT3; FYN; HCLS1; IFNG; IL12B; IL18; IL21; IL7R; JAK3; PTPRC; SOCS1; STAT1; STAT4; TNFSF18
GO:0034113	heterotypic cell-cell adhesion	2.74	4.49e-03	3.70e-02	9/45	CD1D; CD200R1; CD2; ITGA4; ITGAD; ITGB2; ITGB7; LCK; PTPRC
GO:0071216	cellular response to biotic stimulus	2.70	1.47e-06	2.07e-05	27/137	BTK; CARD16; CARD17; CASP1; CCL5; CCR5; CD274; CD40; CD6; CXCL10; CXCL11; CXCL13; CXCL9; GFI1; IL12B; IL18; IRF8; KLRK1; LILRB1; PDCD1LG2; PTAFR; PTPN22; STAP1; SYK; TNFAIP3; TNFRSF1B; TNIP3
GO:0098542	defense response to other organism	2.69	3.23e-11	7.52e-10	51/260	AIM2; APOBEC3C; APOBEC3F; APOBEC3G; APOBEC3H; BIRC3; C5AR1; CCDC88B; CD40; CD4; CFP; CLEC6A; COTL1; CXCL10; CXCL13; CXCL9; GBP1; GNLY; HLA-E; IFNG; JCHAIN; IGLL1; IL12B; IL2RA; IL33; IRF1; IRF4; IRF8; KLRK1; LILRB1; LOC728392; LTA; LYZ; MPEG1; NLRC5; NLRP1; PLAC8; PRF1; PTPRC; RNASE6; SELP; SLAMF8; SLC11A1; SPN; STAT1; SYK; TLR8; TNFAIP3; TNFRSF14; TNFSF8; TRIM22; TSPAN32
GO:0007162	negative regulation of cell adhesion	2.68	7.87e-08	1.39e-06	34/174	ADAMDEC1; ANGPT2; VSIR; CCL21; CCL25; CD274; CD74; CTLA4; RIPOR2; FOXP3; GBP1; IDO1; IL2RA; IRF1; JAK3; LAG3; LAX1; LILRB1; LPXN; PAG1; PDCD1LG2; PLA2G2D; PTPN22; PTPRC; RUNX3; SOCS1; SPN; TBX21; TGFBI; TIGIT; TNFAIP8L2; TNFRSF14; WNT1; XCL1
GO:0002237	response to molecule of bacterial origin	2.58	6.98e-09	1.35e-07	42/223	B2M; C5AR1; CARD16; CARD17; CASP1; CCL5; CCR5; CCR7; CD274; CD40; CD6; CD96; CNR2; CSF2RB; CXCL10; CXCL11; CXCL13; CXCL9; FASLG; GFI1; IDO1; IL10RA; IL12B; IL12RB2; IL18; IRF8; KLRK1; LILRB1; LTA; PDCD1LG2; PLCG2; PTAFR; PTGER4; PTPN22; SELE; SELP; SLC11A1; STAP1; TNFAIP3; TNFRSF1B; TNIP3; VCAM1
GO:0050727	regulation of inflammatory response	2.58	5.61e-10	1.17e-08	48/255	ABCD2; BIRC3; BTK; C1QA; C1S; C3; C5AR1; C7; CCL5; CCR2; CCR7; CD19; CD200R1; CD28; CD6; CFHR1; CFH; CFP; CNR2; CR1; CR2; CREB3L3; DNASE1L3; ETS1; FOXP3; GBP5; GHRL; GPSM3; HLA-E; IDO1; IL12B; IL18; IL21; IL2RA; IL33; ITGB2; LOC728392; LTA; NLRP1; PIK3CG; PTGER4; PTPRC; SELE; SLAMF8; STAP1; TNFAIP3; TNFAIP8L2; TNFRSF1B; XCL1
GO:0032103	positive regulation of response to external stimulus	2.54	4.22e-08	7.78e-07	39/211	AIF1; BTK; C3; C5AR1; CCL19; CCL21; CCL5; CCR2; CCR4; CCR6; CCR7; CD28; CD6; CD74; CREB3L3; CXCL10; CXCL13; ETS1; RIPOR2; GBP5; GHRL; GPSM3; HLA-E; IDO1; IL12B; IL16; IL18; IL21; IL33; ITGB2; LTA; NCKAP1L; PIK3CG; PTGER4; PTK2B; RAC2; STAP1; XCL1; XCL2
GO:0036230	granulocyte activation	2.44	9.08e-09	1.72e-07	46/259	ARHGAP9; ATP8A1; B2M; BIN2; C3; C5AR1; CCL5; CCR2; CD53; ADGRE5; ADA2; CFP; CLEC12A; CLEC4C; CLEC5A; COTL1; CR1; CTSS; CYBB; DNASE1L3; DOCK2; FCN1; FGL2; GMFG; ARHGAP45; HVCN1; IL18RAP; IL18; ITGAL; ITGB2; KCNAB2; LRMP; LYZ; NCKAP1L; P2RX1; PGM1; PLAC8; PTAFR; PTPRC; RAB37; RHOF; SELL; SLC11A1; SYK; TBC1D10C; TNFRSF1B
GO:0031348	negative regulation of defense response	2.38	1.51e-04	1.71e-03	21/121	ABCD2; CD200R1; CD96; CNR2; CR1; ETS1; FOXP3; GHRL; HLA-E; IL12B; IL2RA; KIR2DL4; LILRB1; NLRC5; PTGER4; PTPRC; SERPINB9; SLAMF8; TNFAIP3; TNFAIP8L2; TNFRSF1B
GO:0007229	integrin-mediated signaling pathway	2.38	2.71e-03	2.39e-02	13/75	FERMT3; FYB1; ITGA4; ITGAD; ITGAL; ITGB2; ITGB7; LAT; PLEK; PTK2B; SYK; TSPAN32; VAV1
GO:0002526	acute inflammatory response	2.31	3.37e-04	3.60e-03	20/119	BTK; C1QA; C1S; C3; C5AR1; C7; CCR7; CD19; CD6; CFHR1; CFH; CFP; CR1; CR2; CREB3L3; DNASE1L3; HLA-E; PIK3CG; TREM1; VCAM1
GO:0002446	neutrophil mediated immunity	2.29	2.63e-07	4.19e-06	42/252	ARHGAP9; ATP8A1; B2M; BIN2; C3; C5AR1; CD53; ADGRE5; ADA2; CFP; CLEC12A; CLEC4C; CLEC5A; COTL1; CR1; CTSS; CYBB; DNASE1L3; DOCK2; FCN1; FGL2; GMFG; ARHGAP45; HVCN1; ITGAL; ITGB2; KCNAB2; LRMP; LYZ; NCKAP1L; P2RX1; PGM1; PLAC8; PTAFR; PTPRC; RAB37; RHOF; SELL; SLC11A1; SYK; TBC1D10C; TNFRSF1B
GO:0050920	regulation of chemotaxis	2.29	5.23e-05	6.36e-04	26/156	AIF1; ANGPT2; C5AR1; CCL19; CCL21; CCL5; CCR2; CCR4; CCR6; CCR7; CD74; CXCL10; CXCL13; RIPOR2; GPR183; GPR18; GPSM3; IL16; KLRK1; NCKAP1L; PTK2B; RAC2; SLAMF8; STAP1; XCL1; XCL2
GO:1904950	negative regulation of establishment of protein localization	2.26	1.14e-03	1.06e-02	17/103	BANK1; CARD16; CARD17; CD200R1; CD22; DERL3; FOXP3; GBP1; GHRL; IL33; LILRB1; PTGER4; PTPN22; SRGN; TLR8; TNFAIP3; TNFRSF4
GO:0032635	interleukin-6 production	2.23	3.45e-03	2.99e-02	14/86	BANK1; CD200R1; FOXP3; GHRL; IL18RAP; IL18; IL33; INPP5D; NCKAP1L; PTAFR; PTPN22; SLAMF1; TLR8; TNFAIP3
GO:0030099	myeloid cell differentiation	2.18	1.53e-05	2.04e-04	33/208	B2M; BATF3; CAMK4; CCL19; CCR7; CD4; CD74; CLEC5A; ETS1; EVI2B; FLI1; GAB3; GP1BA; GPR171; GPR183; GPR55; HCLS1; IFNG; IKZF1; IL12B; INPP5D; IRF4; IRF8; JAK3; LILRB1; NCKAP1L; PIK3CD; PRKCB; PRKCQ; PTK2B; RASSF2; STAT1; UBD
GO:0048017	inositol lipid-mediated signaling	2.16	1.94e-03	1.80e-02	17/108	CCL5; CD28; FLT3; FYN; HCLS1; HCST; IL18; LIME1; NCF1; PIK3CD; PIK3CG; PIK3R5; PPP1R16B; PRR5L; PTAFR; SELP; WNT16
GO:0070555	response to interleukin-1	2.14	3.77e-03	3.16e-02	15/96	CCL13; CCL17; CCL19; CCL21; CCL22; CCL25; CCL5; CD38; CD40; ETS1; GBP1; GBP2; SELE; XCL1; XCL2
GO:0019058	viral life cycle	2.13	7.05e-04	7.08e-03	21/135	APOBEC3C; APOBEC3F; APOBEC3G; APOBEC3H; CCL5; CCR5; CD28; CD4; CD74; CLEC5A; CR1; CR2; CXCR6; FCN1; GPR15; ITGB7; LAMP3; SELPLG; SLAMF1; TNFRSF14; TNFRSF4
GO:0018212	peptidyl-tyrosine modification	2.12	4.74e-06	6.43e-05	39/252	ABI3; BANK1; BLK; BTK; CASS4; CCL5; CD3E; CD40; CD4; CD74; CSF2RB; FLT3; FYN; GHRL; HCLS1; IFNG; IL12B; IL12RB2; IL18; IL21; IL3RA; IL5RA; IL7; ITGB2; ITK; JAK3; LCK; NCF1; PTK2B; PTPRC; SAMSN1; SLA; SOCS1; STAP1; SYK; TNFRSF14; TNFSF18; TXK; ZAP70
GO:0007163	establishment or maintenance of cell polarity	2.06	5.57e-03	4.45e-02	15/100	CCL19; CCL21; CCR7; CD3G; DOCK2; DOCK8; RIPOR2; NCKAP1L; PARVG; PTK2B; RHOF; RHOH; CARMIL2; SPN; WNT7A
GO:0043087	regulation of GTPase activity	2.05	2.46e-05	3.13e-04	36/241	ACAP1; AGAP2; ALDH1A1; ARHGAP15; ARHGAP25; ARHGAP30; ARHGAP4; ARHGAP9; CCL13; CCL17; CCL19; CCL21; CCL22; CCL25; CCL5; CCR7; CD40; CXCL13; DOCK11; DOCK2; DOCK8; FGD2; GPR65; ARHGAP45; KLRK1; NCKAP1L; PTK2B; RASAL3; RASGRP2; RGS18; RHOH; TAGAP; TBC1D10C; VAV1; XCL1; XCL2
GO:0072507	divalent inorganic cation homeostasis	2.03	5.20e-07	7.70e-06	52/352	C5AR1; CCL13; CCL19; CCL21; CCL5; CCR2; CCR4; CCR5; CCR6; CCR7; CCR8; CD19; CD38; CD40; CD4; CD52; CLIC2; CORO1A; CXCL10; CXCL11; CXCL13; CXCL9; CXCR3; CXCR5; CXCR6; FASLG; FYN; GHRL; GPR174; GPR18; GPR55; GPR65; JSRP1; LCK; LIME1; MCOLN2; P2RX1; P2RY10; P2RY8; PIK3CG; PLCG2; PRKCB; PTGDR; PTGER4; PTK2B; PTPRC; S1PR4; SLC11A1; SLC24A4; TMC8; XCL1; XCR1

Factor 17 : 2 significant GO terms

GeneSet	description	enrichRatio	pValue	FDR	GeneRatio	geneSymbols
GO:0022613	ribonucleoprotein complex biogenesis	6.12	4.02e-05	1.64e-02	8/52	BOP1; DCAF13; AGO2; EIF3H; EXOSC4; MTERF3; PRKAA2; RRS1
GO:0098742	cell-cell adhesion via plasma-membrane adhesion molecules	3.96	1.31e-08	1.06e-05	23/231	AMIGO2; CDH7; CNTN2; PCDHB14; PCDHGA10; PCDHGA11; PCDHGA1; PCDHGA2; PCDHGA3; PCDHGA4; PCDHGA5; PCDHGA6; PCDHGA7; PCDHGA8; PCDHGA9; PCDHGB1; PCDHGB2; PCDHGB3; PCDHGB4; PCDHGB5; PCDHGB6; PCDHGC4; PCDHGC5

Factor 18 : 63 significant GO terms

GeneSet	description	enrichRatio	pValue	FDR	GeneRatio	geneSymbols
GO:0035456	response to interferon-beta	33.80	0.00e+00	0.00e+00	13/19	AIM2; BST2; IFI16; IFIT1; IFIT3; IFITM1; IFITM3; IFNB1; IRF1; PLSCR1; STAT1; TLR3; XAF1
GO:0034340	response to type I interferon	32.90	0.00e+00	0.00e+00	32/48	BST2; HLA-E; HLA-F; HLA-G; IFI27; IFI35; IFI6; IFIT1; IFIT2; IFIT3; IFITM1; IFITM3; IFNB1; IRF1; IRF7; IRF9; ISG15; ISG20; MX1; MX2; NLRC5; OAS1; OAS2; OAS3; OASL; PSMB8; RSAD2; SAMHD1; STAT1; USP18; XAF1; ZBP1
GO:0035455	response to interferon-alpha	30.40	2.78e-11	1.62e-09	8/13	BST2; EIF2AK2; IFIT2; IFIT3; IFITM1; IFITM3; LAMP3; MX2
GO:0032069	regulation of nuclease activity	19.70	3.09e-05	6.62e-04	4/10	OAS1; OAS2; OAS3; OASL
GO:0009615	response to virus	17.10	0.00e+00	0.00e+00	56/162	AIM2; APOBEC3A; APOBEC3F; APOBEC3G; APOBEC3H; BST2; CCL5; CCL8; CXCL10; DDX58; DDX60; DHX58; EIF2AK2; GBP1; HERC5; IFI16; IFI27; IFI44L; IFI44; IFI6; IFIH1; IFIT1; IFIT2; IFIT3; IFIT5; IFITM1; IFITM3; IFNB1; IL15; IL27; IFNL2; IFNL3; IFNL1; IRF1; IRF7; IRF9; ISG15; ISG20; LGALS9; MX1; MX2; NLRC5; OAS1; OAS2; OAS3; OASL; PARP9; PLSCR1; PRF1; RSAD2; RTP4; SAMHD1; STAT1; TLR3; TRIM22; TRIM34
GO:0032606	type I interferon production	16.80	2.66e-15	2.17e-13	15/44	DDX58; DHX58; HERC5; IFI16; IFIH1; IRF1; IRF7; ISG15; NLRC5; NMI; STAT1; TLR3; UBA7; UBE2L6; ZBP1
GO:0002507	tolerance induction	15.60	1.36e-06	4.44e-05	6/19	CD274; HLA-E; HLA-G; ICOS; IDO1; LGALS9
GO:0006471	protein ADP-ribosylation	14.10	1.38e-04	2.56e-03	4/14	PARP10; PARP14; PARP9; WARS
GO:0043331	response to dsRNA	13.70	2.21e-05	4.86e-04	5/18	DDX58; IFIH1; IFIT1; IFNB1; TLR3
GO:0034341	response to interferon-gamma	11.90	0.00e+00	0.00e+00	31/129	B2M; BST2; CASP1; CCL5; CCL7; CCL8; GBP1; GBP4; GBP5; HLA-E; HLA-F; HLA-G; IFITM1; IFITM3; IRF1; IRF7; IRF9; LGALS9; NLRC5; NMI; OAS1; OAS2; OAS3; OASL; PARP14; PARP9; SOCS1; STAT1; TLR3; TRIM22; TRIM34
GO:0002831	regulation of response to biotic stimulus	10.90	3.45e-12	2.55e-10	15/68	AIM2; APOBEC3F; APOBEC3G; CARD16; CD274; DDX58; DDX60; DHX58; HERC5; IFIT1; IL15; IL27; OPTN; PARP9; STAT1
GO:0098542	defense response to other organism	10.80	0.00e+00	0.00e+00	57/260	AIM2; APOBEC3A; APOBEC3F; APOBEC3G; APOBEC3H; BATF2; BST2; CXCL10; DDX58; DDX60; DHX58; EIF2AK2; GBP1; GNLY; HERC5; HLA-E; IFI16; IFI27; IFI44L; IFI6; IFIH1; IFIT1; IFIT2; IFIT3; IFIT5; IFITM1; IFITM3; IFNB1; IL15; IL22RA1; IL27; IFNL2; IFNL3; IFNL1; IRF1; IRF7; IRF9; ISG15; ISG20; MX1; MX2; NLRC5; OAS1; OAS2; OAS3; OASL; OPTN; PARP9; PLSCR1; PRF1; RSAD2; RTP4; SAMHD1; STAT1; TLR3; TRIM22; TRIM34
GO:0044764	multi-organism cellular process	10.70	8.00e-05	1.59e-03	5/23	DDX58; DDX60; DHX58; IFIH1; IRF7
GO:0032196	transposition	10.40	4.95e-04	7.74e-03	4/19	APOBEC3A; APOBEC3F; APOBEC3G; APOBEC3H
GO:0019058	viral life cycle	9.87	0.00e+00	0.00e+00	27/135	APOBEC3A; APOBEC3F; APOBEC3G; APOBEC3H; BST2; CCL5; CD80; EIF2AK2; IFI16; IFI27; IFIT1; IFIT5; IFITM1; IFITM3; IFNB1; IFNL3; ISG15; ISG20; LAMP3; LGALS9; MX1; OAS1; OAS3; OASL; PARP10; PLSCR1; RSAD2
GO:0043900	regulation of multi-organism process	9.67	0.00e+00	0.00e+00	38/194	AIM2; APOBEC3A; APOBEC3F; APOBEC3G; APOBEC3H; BST2; CARD16; CCL5; DDX58; DDX60; DHX58; EIF2AK2; HERC5; IFI16; IFI27; IFIT1; IFIT5; IFITM1; IFITM3; IFNB1; IL15; IL27; IFNL3; ISG15; ISG20; LAMP3; LGALS9; MX1; OAS1; OAS3; OASL; OPTN; PARP10; PARP9; PLSCR1; PRF1; RSAD2; STAT1
GO:0070988	demethylation	8.58	1.06e-03	1.57e-02	4/23	APOBEC3A; APOBEC3F; APOBEC3G; APOBEC3H
GO:0009451	RNA modification	8.23	1.25e-03	1.82e-02	4/24	APOBEC3A; APOBEC3F; APOBEC3G; APOBEC3H
GO:0060759	regulation of response to cytokine stimulus	8.05	3.36e-10	1.61e-08	15/92	CARD16; CASP1; CCL5; DDX58; IFIH1; IRF7; NLRC5; PARP14; PARP9; SAMHD1; SOCS1; STAP1; STAT1; USP18; ZBP1
GO:0042092	type 2 immune response	7.59	1.71e-03	2.40e-02	4/26	IDO1; IFNB1; IFNL1; RSAD2
GO:0032615	interleukin-12 production	7.26	5.53e-04	8.49e-03	5/34	HLA-G; IDO1; IRF1; LGALS9; TLR3
GO:0045088	regulation of innate immune response	6.70	0.00e+00	0.00e+00	30/221	AIM2; CCL5; DDX58; DDX60; DHX58; GBP5; HLA-E; HLA-G; IFI16; IFIH1; IFNB1; IL18RAP; IRF1; IRF7; KIR2DL4; LAG3; LGALS9; NLRC5; NMI; PARP14; PARP9; PLSCR1; RSAD2; SAMHD1; SERPING1; SOCS1; STAT1; TLR3; USP18; ZBP1
GO:0072527	pyrimidine-containing compound metabolic process	6.44	3.00e-04	5.09e-03	6/46	APOBEC3A; APOBEC3F; APOBEC3G; APOBEC3H; CMPK2; TYMP
GO:0097696	STAT cascade	6.39	9.60e-07	3.26e-05	11/85	CCL5; IFNB1; IL15; IFNL2; IFNL3; IFNL1; NMI; PARP14; PARP9; SOCS1; STAT1
GO:0070206	protein trimerization	6.17	3.74e-03	4.83e-02	4/32	HLA-G; MLKL; TRIM22; TRIM34
GO:0002697	regulation of immune effector process	6.00	8.88e-16	8.03e-14	30/247	AIM2; APOBEC3F; APOBEC3G; B2M; BST2; C2; CD80; CFB; DDX58; DDX60; DHX58; HERC5; HLA-E; HLA-F; HLA-G; IFIT1; IFNB1; IL15; IL18RAP; IL27; IFNL1; KIR2DL4; LAG3; LGALS9; PARP9; RSAD2; SERPING1; STAT1; TLR3; ZNF683
GO:0001906	cell killing	5.94	2.26e-07	8.35e-06	13/108	APOL1; B2M; GNLY; GZMB; HLA-E; HLA-F; HLA-G; IL18RAP; KIR2DL4; LAG3; LGALS9; PRF1; STAP1
GO:0001818	negative regulation of cytokine production	5.74	1.85e-10	9.40e-09	20/172	BST2; CARD16; CARD17; CD274; DDX58; DHX58; GBP1; HERC5; IDO1; IFIH1; IFNB1; IFNL1; ISG15; LAG3; LGALS9; NLRC5; NMI; PDCD1LG2; UBA7; UBE2L6
GO:0006968	cellular defense response	5.74	1.65e-03	2.36e-02	5/43	GNLY; HLA-G; KIR2DL4; LGALS3BP; PRF1
GO:0070646	protein modification by small protein removal	5.66	2.12e-04	3.76e-03	7/61	DDX58; IFIH1; PSMB10; PSMB8; PSMB9; PSME2; USP18
GO:0032609	interferon-gamma production	5.61	1.00e-05	2.58e-04	10/88	BTN3A1; BTN3A2; CD274; IL18RAP; IL27; IFNL1; ISG15; LGALS9; PDCD1LG2; TLR3
GO:0061025	membrane fusion	5.57	2.35e-04	4.08e-03	7/62	MX1; MX2; OTOF; SAMD9L; SAMD9; TAP1; TAP2
GO:0032612	interleukin-1 production	5.32	3.17e-04	5.26e-03	7/65	AIM2; CARD16; CARD17; CASP1; GBP5; IFI16; LGALS9
GO:0002449	lymphocyte mediated immunity	5.31	1.56e-08	6.34e-07	17/158	B2M; BTN3A2; BTN3A3; C2; GZMB; HLA-E; HLA-F; HLA-G; IFNB1; IL18RAP; IRF7; KIR2DL4; LAG3; LGALS9; PRF1; RSAD2; SERPING1
GO:0002440	production of molecular mediator of immune response	4.98	4.52e-06	1.31e-04	12/119	B2M; BST2; DDX58; HLA-E; HLA-G; IFNB1; IL18RAP; KIR2DL4; RSAD2; SAMHD1; TLR3; TNFSF13B
GO:0031348	negative regulation of defense response	4.90	5.38e-06	1.51e-04	12/121	DHX58; HLA-E; HLA-G; IFI16; IFIT1; KIR2DL4; LGALS9; NLRC5; NMI; PARP14; SAMHD1; SERPING1
GO:0001819	positive regulation of cytokine production	4.85	4.95e-12	3.35e-10	27/275	AIM2; B2M; CASP1; CD274; CD80; DDX58; DDX60; DHX58; EIF2AK2; GBP5; HLA-E; HLA-G; HPSE; IDO1; IFI16; IFIH1; IL15; IL27; IFNL1; IRF1; IRF7; KIR2DL4; LGALS9; RSAD2; STAT1; TLR3; ZBP1
GO:0031349	positive regulation of defense response	4.74	8.25e-12	5.17e-10	27/281	AIM2; CCL5; DDX58; DDX60; DHX58; GBP5; HLA-E; HLA-G; IDO1; IFI16; IFIH1; IFNB1; IL15; IL18RAP; IRF1; IRF7; KIR2DL4; LAG3; LGALS9; NLRC5; OPTN; PARP9; PLSCR1; RSAD2; STAP1; TLR3; ZBP1
GO:0042107	cytokine metabolic process	4.73	6.48e-04	9.76e-03	7/73	CD80; IL27; IRF1; IRF7; LAG3; NMI; TLR3
GO:0007249	I-kappaB kinase/NF-kappaB signaling	4.59	1.05e-05	2.58e-04	12/129	APOL3; BST2; CARD16; CASP1; IFIT5; LGALS9; OPTN; SECTM1; STAT1; TLR3; TNFSF10; TRIM22
GO:0050866	negative regulation of cell activation	4.59	1.05e-05	2.58e-04	12/129	CD274; CD80; CTLA4; HLA-G; IDO1; IFNB1; IFNL1; IRF1; LAG3; LGALS9; PDCD1LG2; SOCS1
GO:0002683	negative regulation of immune system process	4.58	4.60e-11	2.50e-09	26/280	BST2; CD274; CD80; CTLA4; DHX58; GBP1; HLA-E; HLA-G; IDO1; IFI16; IFIT1; IFNB1; IFNL1; IRF1; KIR2DL4; LAG3; LGALS9; NLRC5; NMI; PARP14; PDCD1LG2; SAMHD1; SERPING1; SOCS1; STAP1; TLR3
GO:0019882	antigen processing and presentation	4.49	3.84e-04	6.25e-03	8/88	B2M; HLA-E; HLA-F; HLA-G; LAG3; PSMB8; TAP1; TAP2
GO:0002250	adaptive immune response	4.45	5.11e-10	2.31e-08	24/266	B2M; BTN3A1; BTN3A2; BTN3A3; C2; CD274; CD80; CTLA4; HLA-E; HLA-F; HLA-G; IFNB1; IL18RAP; IL27; IRF1; IRF7; LAMP3; PRF1; RSAD2; SERPING1; TAP1; TAP2; TNFSF13B; ZNF683
GO:0071887	leukocyte apoptotic process	4.36	2.43e-03	3.36e-02	6/68	CCL5; CD274; HSH2D; IDO1; IRF7; LGALS9
GO:0050663	cytokine secretion	4.22	1.12e-05	2.67e-04	13/152	AIM2; BTN3A1; BTN3A2; CARD16; CARD17; CASP1; CD274; DDX58; GBP1; GBP5; IFIH1; LGALS9; SOCS1
GO:0070661	leukocyte proliferation	4.22	4.67e-07	1.65e-05	17/199	BTN3A1; CCL5; CCL8; CD274; CD80; CTLA4; HLA-E; HLA-G; IDO1; IFNB1; IL15; IL27; IRF1; LGALS9; PDCD1LG2; PSMB10; TNFSF13B
GO:1903706	regulation of hemopoiesis	3.99	2.23e-07	8.35e-06	19/235	B2M; CCR1; CD80; CTLA4; EIF2AK2; HLA-G; IFNB1; IL15; IL27; IFNL1; IRF1; IRF7; ISG15; LGALS9; RASSF2; SOCS1; STAT1; TLR3; ZNF683
GO:0071216	cellular response to biotic stimulus	3.96	9.67e-05	1.83e-03	11/137	CARD16; CARD17; CASP1; CCL5; CD274; CD80; CMPK2; CXCL10; CXCL11; PDCD1LG2; STAP1
GO:0042110	T cell activation	3.82	1.12e-08	4.78e-07	24/310	B2M; BTN3A1; CCL5; CD274; CD80; CTLA4; HLA-E; HLA-G; HSH2D; ICOS; IDO1; IFNB1; IL15; IL27; IFNL1; IRF1; LAG3; LGALS9; PDCD1LG2; PSMB10; RSAD2; SOCS1; TNFSF13B; ZNF683
GO:0007162	negative regulation of cell adhesion	3.69	4.72e-05	9.61e-04	13/174	CD274; CD80; CTLA4; GBP1; HLA-G; IDO1; IFNB1; IFNL1; IRF1; LAG3; LGALS9; PDCD1LG2; SOCS1
GO:0007159	leukocyte cell-cell adhesion	3.62	3.96e-06	1.20e-04	17/232	CCL5; CD274; CD80; CTLA4; HLA-E; HLA-G; ICOS; IDO1; IFNB1; IL15; IFNL1; IRF1; LAG3; LGALS9; PDCD1LG2; SOCS1; TNFSF13B
GO:0032103	positive regulation of response to external stimulus	3.51	2.18e-05	4.86e-04	15/211	CCL5; CCL7; CCR1; CXCL10; DDX60; DHX58; FPR2; GBP5; HLA-E; IDO1; IL15; LGALS9; OPTN; STAP1; TLR3
GO:0002237	response to molecule of bacterial origin	3.10	1.59e-04	2.88e-03	14/223	B2M; CARD16; CARD17; CASP1; CCL5; CD274; CD80; CMPK2; CXCL10; CXCL11; IDO1; LGALS9; PDCD1LG2; STAP1
GO:0002694	regulation of leukocyte activation	3.09	3.51e-06	1.10e-04	21/336	CCL5; CD274; CD80; CTLA4; HLA-E; HLA-G; ICOS; IDO1; IFNB1; IL15; IL27; IFNL1; IRF1; LAG3; LGALS9; PDCD1LG2; PLSCR1; SOCS1; STAP1; TNFSF13B; ZNF683
GO:0002521	leukocyte differentiation	3.09	6.14e-06	1.67e-04	20/320	B2M; BATF2; CCR1; CD80; CTLA4; HLA-G; IFI16; IFNB1; IL15; IL27; IFNL1; IRF1; IRF7; LGALS9; RASSF2; RSAD2; SH3PXD2A; SOCS1; TLR3; ZNF683
GO:0002764	immune response-regulating signaling pathway	3.06	2.05e-05	4.76e-04	18/290	BTN3A1; BTN3A2; BTN3A3; CTLA4; DDX58; DDX60; DHX58; FPR2; GBP1; HLA-G; IFIH1; IRF1; IRF7; LGALS9; PLSCR1; RSAD2; STAP1; TLR3
GO:0022407	regulation of cell-cell adhesion	3.01	4.47e-05	9.33e-04	17/279	CCL5; CD274; CD80; CTLA4; HLA-E; HLA-G; ICOS; IDO1; IFNB1; IL15; IFNL1; IRF1; LAG3; LGALS9; PDCD1LG2; SOCS1; TNFSF13B
GO:0052547	regulation of peptidase activity	2.97	8.85e-05	1.71e-03	16/266	AIM2; BST2; CARD16; CARD17; CASP1; FAS; IFI16; IFI27; IFI6; LAMP3; LGALS9; PSMB8; PSMB9; PSME2; SERPING1; TNFSF10
GO:0050867	positive regulation of cell activation	2.93	4.73e-04	7.55e-03	13/219	CCL5; CD274; CD80; CTLA4; HLA-E; HLA-G; ICOS; IL15; LGALS9; PDCD1LG2; SOCS1; STAP1; TNFSF13B
GO:0006959	humoral immune response	2.76	3.34e-03	4.46e-02	10/179	BST2; C2; CFB; CXCL10; CXCL11; GNLY; HLA-E; IFNB1; PSMB10; SERPING1
GO:0030099	myeloid cell differentiation	2.61	3.23e-03	4.38e-02	11/208	B2M; BATF2; CCR1; IFI16; IRF7; ISG15; LGALS9; RASSF2; SH3PXD2A; STAT1; TLR3
GO:0051090	regulation of DNA-binding transcription factor activity	2.59	3.48e-03	4.56e-02	11/210	AIM2; CARD16; DDX58; EIF2AK2; IL18RAP; LGALS9; NLRC5; PARP10; TLR3; TRIM22; TRIM34

Factor 19 : 4 significant GO terms

GeneSet	description	enrichRatio	pValue	FDR	GeneRatio	geneSymbols
GO:0007272	ensheathment of neurons	3.63	9.43e-05	1.92e-02	12/74	NCMAP; FAM126A; ID4; KLK6; KLK8; NRG1; NTRK2; NTRK3; RARB; SCN2A; SOX10; TLR2
GO:0043588	skin development	2.88	8.21e-08	3.34e-05	31/241	ALX4; CDH3; DACT2; DSC3; DSG1; DSG3; EDAR; FERMT1; ITGA2; ITGA3; ITGB4; KLK5; KRT14; KRT15; KRT16; KRT17; KRT5; KRT6A; KRT6B; KRT6C; KRT81; KRT83; KRT86; CERS3; LIPK; MET; PDGFA; PKP1; SOSTDC1; TGM5; TP63
GO:0008544	epidermis development	2.87	1.23e-08	1.00e-05	35/273	ALX4; BNC1; CDH3; COL17A1; COL7A1; DCT; DSC3; DSG1; DSG3; EDAR; FERMT1; KLK5; KLK7; KRT14; KRT15; KRT16; KRT17; KRT5; KRT6A; KRT6B; KRT6C; KRT81; KRT83; KRT86; LAMA3; LAMB3; LAMC2; CERS3; LIPK; NTF4; PDGFA; PKP1; SOSTDC1; TGM5; TP63
GO:0043062	extracellular structure organization	2.11	6.03e-05	1.64e-02	31/329	A2M; ADAMTSL2; COL11A1; COL17A1; COL4A6; COL7A1; FERMT1; GFAP; GPM6B; HAS3; HPSE2; ICAM5; ITGA10; ITGA2; ITGA3; ITGB4; ITGB6; KLK5; KLK7; LAMA3; LAMB3; LAMC2; LAMC3; LOXL4; MMP20; MMP7; MYH11; PDGFA; SERPINB5; SERPINF2; VIT

Factor 20 : 60 significant GO terms

GeneSet	description	enrichRatio	pValue	FDR	GeneRatio	geneSymbols
GO:0001945	lymph vessel development	9.53	5.99e-07	3.48e-05	8/18	EFNB2; FLT4; FOXC2; HEG1; SOX18; TMEM204; VEGFA; VEGFC
GO:0001570	vasculogenesis	7.42	7.01e-12	1.14e-09	18/52	APLNR; CAV1; CD34; ACKR3; EGFL7; FOXF1; HEG1; HEY1; KDR; MYOCD; PDGFRB; RAMP2; RASIP1; SOX17; SOX18; TGFBR2; TIE1; VEGFA
GO:0035924	cellular response to vascular endothelial growth factor stimulus	6.95	5.64e-08	4.17e-06	12/37	DLL4; FLT4; ADGRA2; KDR; JCAD; NRP1; PDGFRB; PGF; PTP4A3; RAMP2; VEGFA; VEGFC
GO:0003170	heart valve development	6.34	5.50e-08	4.17e-06	13/44	ADAMTS9; DLL4; GJA5; HEY1; HEYL; JAG1; MEF2C; NOS3; PRDM1; SLIT2; SLIT3; TGFBR2; TNFRSF1B
GO:0003158	endothelium development	5.51	6.33e-10	7.37e-08	19/74	APOLD1; CD34; CDH5; CLDN5; COL18A1; GJA4; GJA5; HEG1; HEY1; ID1; JAG1; KDR; NRP1; PDE2A; PECAM1; S1PR1; SOX17; SOX18; ZEB1
GO:0060840	artery development	5.00	4.34e-07	2.72e-05	14/60	ADAMTS9; DLL4; EFNB2; FOXF1; GJA5; ADGRF5; HEY1; JAG1; MYOCD; NRP1; PDGFRB; PRDM1; TBX2; VEGFA
GO:0010644	cell communication by electrical coupling	4.87	2.92e-03	3.78e-02	5/22	CASQ2; CAV1; GJA5; GJC2; HRC
GO:0048010	vascular endothelial growth factor receptor signaling pathway	4.72	1.40e-05	5.71e-04	11/50	ELMO1; FLT4; FYN; ITGB3; KDR; MMRN2; NRP1; PGF; TMEM204; VEGFA; VEGFC
GO:0009187	cyclic nucleotide metabolic process	4.55	6.74e-04	1.22e-02	7/33	ADCY4; GUCY1A2; GUCY1B1; NPR1; PDE1A; PDE2A; PDE7B
GO:0048008	platelet-derived growth factor receptor signaling pathway	4.44	1.88e-03	2.59e-02	6/29	MYOCD; NRP1; PDGFD; PDGFRB; PTGIR; VEGFA
GO:0060976	coronary vasculature development	4.44	1.88e-03	2.59e-02	6/29	APLNR; MYOCD; NRP1; PDGFRB; PRDM1; VEGFA
GO:0061383	trabecula morphogenesis	4.41	8.15e-04	1.38e-02	7/34	ADAMTS1; CCM2L; DLL4; HEG1; HEY1; S1PR1; TEK
GO:0001525	angiogenesis	4.41	0.00e+00	0.00e+00	71/345	ADAMTS9; ANGPT2; APLNR; APOLD1; AQP1; ARHGAP24; CALCRL; CAV1; CD34; CDH13; CDH5; CLEC14A; COL15A1; COL18A1; COL4A1; COL4A2; CSPG4; ACKR3; DLL4; DYSF; ECSCR; EFNB2; EGFL7; ENPEP; ENPP2; EPAS1; ESM1; ETS1; FLT4; FOXC2; GJA5; ADGRA2; HEY1; HGF; HSPG2; ID1; ITGB3; JAG1; KDR; JCAD; MCAM; MEOX2; MMRN2; NOS3; NPR1; NRP1; PDGFRB; PECAM1; PGF; PTPRB; PTPRM; RAMP2; RAMP3; RASIP1; RHOJ; ROBO4; RSPO3; S1PR1; SCG2; SLIT2; SOX17; SOX18; STAB1; TAL1; TEK; TGFBR2; THSD7A; THY1; TIE1; VEGFA; VEGFC
GO:0090130	tissue migration	4.36	2.58e-14	1.05e-11	36/177	ACTC1; ADAMTS9; ANGPT2; CDH13; CLEC14A; DLL4; EFNB2; ENPP2; ETS1; FLT4; FOXC2; FOXF1; ADGRA2; HBEGF; ID1; ITGB3; KDR; JCAD; MEF2C; MEOX2; MMRN2; NOS3; NRP1; PECAM1; PTP4A3; PTPRG; PTPRM; RHOJ; SCG2; SLIT2; SOX18; TEK; TGFBR2; VEGFA; VEGFC; ZEB2
GO:0050918	positive chemotaxis	3.97	1.63e-04	3.68e-03	10/54	ANGPT2; CDH13; HGF; KDR; NRP1; PGF; S1PR1; SCG2; VEGFA; VEGFC
GO:0001667	ameboidal-type cell migration	3.65	2.20e-13	5.96e-11	41/241	ADAMTS9; ANGPT2; CDH13; CLEC14A; CYGB; DLL4; EDNRB; EFNB2; ENPP2; ETS1; FLT4; FOXC2; ADGRA2; HBEGF; ID1; ITGB3; KDR; JCAD; MEF2C; MEOX2; MMRN2; NOS3; NRP1; PECAM1; PTP4A3; PTPRG; PTPRM; RHOJ; SCG2; SEMA3G; SEMA5B; SEMA6B; SLIT2; SOX17; SOX18; TEK; TGFBR2; TNS1; VEGFA; VEGFC; ZEB2
GO:1901342	regulation of vasculature development	3.62	4.44e-12	9.05e-10	37/219	ADAMTS9; ANGPT2; APLNR; AQP1; CD34; CDH5; COL4A2; DLL4; ECSCR; EFNB2; ENPP2; ETS1; FOXC2; ADGRA2; HEY1; HGF; HSPG2; ID1; KDR; JCAD; MEOX2; MMRN2; MYOCD; NOS3; NPR1; NRP1; PDGFD; PGF; PTPRM; RAMP2; RHOJ; STAB1; TEK; TGFBR2; TIE1; VEGFA; VEGFC
GO:0003205	cardiac chamber development	3.45	1.85e-06	9.42e-05	19/118	ADAMTS1; CCM2L; DLL4; FOXF1; GJA5; HEG1; HEY1; HEYL; JAG1; MEF2C; MYOCD; NOS3; NRP1; PRDM1; SLIT2; SLIT3; TBX2; TEK; TGFBR2
GO:0003007	heart morphogenesis	3.25	4.39e-08	3.97e-06	27/178	ACTC1; ADAMTS1; CCM2L; CLDN5; DLC1; DLL4; FAT4; FOXF1; GJA5; HEG1; HEY1; HEYL; JAG1; MEF2C; MYOM1; NOS3; NRP1; S1PR1; SLIT2; SLIT3; SOX17; SOX18; SPRY1; TBX2; TEK; TGFBR2; VEGFA
GO:0071559	response to transforming growth factor beta	3.24	1.55e-06	8.42e-05	21/139	ADAMTSL2; CAV1; CAV2; CDH5; CLDN5; CLEC3B; COL4A2; FYN; ID1; ITGA8; LRRC32; NRROS; MEF2C; MYOCD; PDE2A; PDE3A; PDGFD; PRDM16; SMAD9; TGFBR2; ZEB1
GO:0035051	cardiocyte differentiation	3.09	1.46e-04	3.68e-03	14/97	ACTC1; ALPK3; EFNB2; JAG1; MEF2C; MYH11; MYOCD; MYOM1; PDGFRB; SOX17; SOX18; SPRY1; TBX2; VEGFA
GO:0014812	muscle cell migration	3.06	4.12e-03	4.73e-02	8/56	ADAMTS1; ITGB3; MEF2C; MYOCD; NRP1; PDGFD; PDGFRB; SLIT2
GO:0003014	renal system process	2.91	1.25e-03	1.95e-02	11/81	ADCY4; AQP1; AVPR1A; CD34; EDNRB; F2R; GJA5; ADGRF5; HBB; MCAM; NPR1
GO:0007498	mesoderm development	2.88	1.38e-03	2.12e-02	11/82	BMX; ETS2; FOXC2; FOXF1; GDF3; ITGA8; ITGB3; SOX17; TAL1; TIE1; VEGFA
GO:0003013	circulatory system process	2.79	7.40e-11	1.00e-08	47/361	ACTC1; ADRA1B; ARHGAP42; AVPR1A; BDKRB2; CASQ2; CAV1; CD34; CLIC2; DLL4; EDNRB; ENPEP; EPAS1; F2R; FLI1; FYN; GJA5; GUCY1B1; HBB; HBEGF; HEG1; HRC; HTR1B; ITGA1; KCNA5; KCNJ2; KCNJ8; KCNN2; MEOX2; MYL4; NOS2; NOS3; NPR1; P2RY1; PDE2A; PDE3A; PLN; PTP4A3; PTPRM; RAMP2; RAMP3; SCN4B; SLIT2; TBX2; TEK; VEGFC; VIP
GO:0050920	regulation of chemotaxis	2.75	3.41e-05	1.21e-03	20/156	ANGPT2; CCL26; CDH13; DYSF; EFNB2; ADGRA2; KDR; MMP28; NRP1; PDGFD; PDGFRB; PGF; S1PR1; SCG2; SEMA3G; SEMA5B; SEMA6B; SLIT2; VEGFA; VEGFC
GO:0051056	regulation of small GTPase mediated signal transduction	2.75	3.54e-06	1.60e-04	25/195	A2M; ADCYAP1R1; ARHGAP23; ARHGAP24; ARHGAP42; ARHGAP6; ARHGEF15; DLC1; F2RL3; F2R; FGD5; GPR20; HEG1; LPAR4; NGF; NRP1; P2RY8; PDGFRB; PLEKHG1; PREX2; RASIP1; RHOJ; SLIT2; SPRY1; SPRY4
GO:0002576	platelet degranulation	2.74	2.04e-03	2.77e-02	11/86	A2M; CLEC3B; HGF; ITGB3; ITIH3; MMRN1; PECAM1; SELP; VEGFA; VEGFC; VWF
GO:0048771	tissue remodeling	2.73	5.53e-04	1.04e-02	14/110	CAV1; CSPG4; DLL4; EPAS1; F2R; FLT4; GJA5; HTR1B; ITGB3; JAG1; MEF2C; NOS3; RSPO3; S1PR1
GO:0033002	muscle cell proliferation	2.72	1.50e-04	3.68e-03	17/134	ADAMTS1; CALCRL; CDH13; HBEGF; HTR1B; MAPK11; MEF2C; MYOCD; NPR1; PDE1A; PDGFD; PDGFRB; PTGIR; S1PR1; TBX2; TGFBR2; VIP
GO:0090287	regulation of cellular response to growth factor stimulus	2.71	2.66e-05	1.03e-03	21/166	ADAMTSL2; CAV1; CAV2; GDF3; ADGRA2; ITGA8; ITGB3; JCAD; NRROS; MMRN2; MYOCD; PRDM16; PTP4A3; SLIT2; SPRY1; SPRY4; TGFBR2; TMEM204; VEGFA; VEGFC; ZEB1
GO:0019932	second-messenger-mediated signaling	2.59	3.04e-08	3.10e-06	39/323	ADCY4; ADCYAP1R1; ADRA1B; ADRA1D; APLNR; AQP1; AVPR1A; CALCRL; CASQ2; CCR10; CDH13; CLIC2; ACKR3; EDNRB; ADGRL4; GNAI1; GNG2; GUCY1A2; GUCY1B1; HRC; KDR; ADGRL2; MCTP1; NOS2; NOS3; NPR1; NR5A2; PDE2A; PDE3A; PLN; PTGIR; RAMP2; RAMP3; RAPGEF4; RCAN2; SELE; SELP; VEGFA; VIP
GO:0007219	Notch signaling pathway	2.59	9.45e-04	1.57e-02	14/116	CDH6; DLL4; EGFL7; FAT4; HEY1; HEYL; JAG1; KCNA5; MFNG; PEAR1; PLN; PTP4A3; TBX2; TGFBR2
GO:2000147	positive regulation of cell motility	2.51	7.04e-08	4.77e-06	39/333	ADAMTS1; VSIR; CAV1; CCL26; CDH13; COL18A1; ACKR3; DYSF; ENPP2; ETS1; F2R; FLT4; FOXC2; FOXF1; ADGRA2; HBEGF; HGF; ITGB3; KDR; JCAD; MCAM; NOS3; NRP1; PDGFD; PDGFRB; PGF; PLVAP; PODXL; RHOJ; S1PR1; SELP; SEMA3G; SEMA5B; SEMA6B; TEK; TGFBR2; THY1; VEGFA; VEGFC
GO:0034330	cell junction organization	2.46	1.61e-04	3.68e-03	20/174	ARHGAP6; CAV1; CDH13; CDH5; CDH6; CDH8; CLDN5; DLC1; F2R; GJA4; GJA5; HEG1; KDR; LIMS2; NRP1; RAMP2; TEK; THY1; TNS1; VEGFA
GO:0035637	multicellular organismal signaling	2.46	1.09e-03	1.77e-02	15/131	AVPR1A; CASQ2; CAV1; DMRT3; GJA5; HRC; KCNA5; KCNJ2; KCNN2; NPR1; PLN; S1PR1; SCN4A; SCN4B; SCN9A
GO:0031589	cell-substrate adhesion	2.45	1.26e-05	5.39e-04	27/236	ADAMTS9; ANGPT2; ARHGAP6; CD34; CDH13; COL13A1; DLC1; EGFLAM; FOXF1; ID1; ITGA1; ITGA7; ITGA8; ITGB3; JAG1; KDR; LYVE1; MMRN1; MMRN2; NID1; NID2; NRP1; PECAM1; TEK; THY1; VEGFA; VWF
GO:0048863	stem cell differentiation	2.45	7.67e-04	1.36e-02	16/140	A2M; EDNRB; FRZB; JAG1; LBH; MEF2C; MYOCD; NRP1; SEMA3G; SEMA5B; SEMA6B; SOX17; SOX18; TAL1; TBX2; ZEB2
GO:0051271	negative regulation of cellular component movement	2.38	8.84e-05	2.48e-03	23/207	ADAMTS9; ANGPT2; CD200; CYGB; DLC1; DLL4; IL33; JAG1; MCTP1; MEF2C; MEOX2; MMP28; MMRN2; MYOCD; NRP1; PTPRG; PTPRM; SEMA3G; SEMA5B; SEMA6B; SLIT2; THY1; TIE1
GO:0040013	negative regulation of locomotion	2.36	1.03e-04	2.78e-03	23/209	ADAMTS9; ANGPT2; CD200; CYGB; DLC1; DLL4; IL33; JAG1; MCTP1; MEF2C; MEOX2; MMP28; MMRN2; MYOCD; NRP1; PTPRG; PTPRM; SEMA3G; SEMA5B; SEMA6B; SLIT2; THY1; TIE1
GO:0001655	urogenital system development	2.33	3.10e-05	1.15e-03	27/248	ADAMTS1; ANGPT2; CD34; COL4A1; EFNB2; ENPEP; FAT4; FOXF1; HEYL; ID3; ITGA8; JAG1; KCNJ8; MEF2C; MYOCD; NID1; NRP1; PDGFD; PDGFRB; PECAM1; PGF; PODXL; SLIT2; SOX17; SPRY1; TEK; VEGFA
GO:0007265	Ras protein signal transduction	2.32	6.76e-05	2.12e-03	25/231	ARHGAP42; ARHGAP6; ARHGEF15; CDH13; DLC1; ELMO1; F2RL3; F2R; FGD5; GPR20; GRAP; HEG1; LPAR4; NGF; NRP1; P2RY8; PDGFRB; PECAM1; PLEKHG1; PREX2; RASGRP2; RASIP1; RHOJ; SPRY1; SPRY4
GO:0060537	muscle tissue development	2.30	4.12e-05	1.40e-03	27/252	ACTC1; ADAMTS9; ALPK3; CCM2L; CAV1; CAV2; DLL4; EFNB2; GJA5; HEG1; HEYL; HLX; HOXD9; ITGA8; MAPK11; MEF2C; MEOX2; MYH11; MYOCD; MYOM1; PDGFRB; PLN; S1PR1; SOX17; TBX2; TGFBR2; VEGFA
GO:0006898	receptor-mediated endocytosis	2.29	4.22e-04	8.60e-03	20/187	CALCRL; CAV1; CAV2; CFI; CUBN; ACKR3; EFNB2; ENPP2; HBA1; HBB; HSPG2; HTR1B; ITGB3; RAMP2; RAMP3; SELE; STAB1; SYT11; TGFBR2; VEGFA
GO:0043062	extracellular structure organization	2.28	3.37e-06	1.60e-04	35/329	A2M; ACAN; ADAMTS4; ADAMTS9; ADAMTSL2; CD34; CETP; COL13A1; COL14A1; COL15A1; COL18A1; COL4A1; COL4A2; CSGALNACT1; EGFLAM; ETS1; FOXF1; HSPG2; ICAM2; ITGA1; ITGA7; ITGA8; ITGB3; JAM2; KDR; LAMA4; MYH11; NID1; NID2; OLFML2A; PECAM1; RAMP2; TNFRSF1B; TNXB; VWF
GO:0007187	G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger	2.25	5.56e-04	1.04e-02	20/191	ADCY4; ADRA1B; ADRA1D; CALCRL; ADGRL4; GNAI1; GNG2; GRM2; GRM8; HTR1B; HTR1F; ADGRL2; P2RY1; PDE2A; PLN; PTGIR; RAMP2; RAMP3; S1PR1; VIP
GO:0046677	response to antibiotic	2.24	7.90e-04	1.37e-02	19/182	ACTC1; ADCYAP1R1; AOC3; AQP1; CRHBP; ETS1; FYN; GNAI1; HBA1; HBB; HGF; HTR1B; ID1; ID3; KCNA5; MEF2C; PDGFD; PDGFRB; TRPC6
GO:0050673	epithelial cell proliferation	2.23	7.11e-05	2.14e-03	27/260	APLNR; CAV1; CAV2; CCL26; CD34; CDH13; DLL4; DYSF; EDNRB; EFNB2; EGFL7; FLT4; ID1; ITGB3; KDR; JCAD; LIMS2; MEF2C; NRP1; PGF; PTPRM; SCG2; TEK; VEGFA; VEGFC; VIP; WFDC1
GO:0010959	regulation of metal ion transport	2.21	8.12e-05	2.36e-03	27/262	ADCYAP1R1; APLNR; CASQ2; CAV1; CLIC2; DYSF; F2RL3; F2R; FYN; GEM; GJC2; HECW2; HRC; KCNA5; KCNJ2; KCNN2; LRRC55; NOS3; PDGFRB; PLN; RAMP3; REM1; SCN4B; TESC; THY1; TRPC6; VIP
GO:0001763	morphogenesis of a branching structure	2.20	3.22e-03	3.91e-02	15/146	COL13A1; COL4A1; DLL4; FAT4; FOXF1; HGF; NRP1; PGF; PRDM1; RASIP1; RSPO3; SLIT2; SPRY1; TGFBR2; VEGFA
GO:0060485	mesenchyme development	2.17	1.17e-03	1.87e-02	19/188	ACTC1; EDNRB; FOXF1; FRZB; HEY1; HEYL; HGF; JAG1; MEF2C; NOS3; NRP1; PDGFRB; SEMA3G; SEMA5B; SEMA6B; SPRY1; TBX2; TGFBR2; ZEB2
GO:0090066	regulation of anatomical structure size	2.16	5.04e-05	1.64e-03	30/298	ADRA1B; AQP1; ARHGAP42; AVPR1A; BDKRB2; CAV1; CCL26; EDNRB; F2R; GJA5; GMFG; HBB; HTR1B; ISLR2; ITGA1; KANK3; KCNA5; LRRC8C; NGF; NOS3; NPR1; NRP1; P2RY1; PTPRM; SEMA3G; SEMA5B; SEMA6B; SLIT2; VEGFA; VIP
GO:0042692	muscle cell differentiation	2.14	5.64e-04	1.04e-02	22/220	ACTC1; ALPK3; AVPR1A; CASQ2; CAV2; DYSF; EDNRB; EFNB2; FOXF1; HEY1; ITGA8; MAPK11; MEF2C; MYH11; MYOCD; MYOM1; PDGFRB; RAMP2; TBX2; TMEM204; VEGFA; ZEB1
GO:0043087	regulation of GTPase activity	2.14	3.40e-04	7.09e-03	24/241	A2M; ARHGAP23; ARHGAP24; ARHGAP42; ARHGAP6; ARHGEF15; CAV2; CCL14; CCL26; DLC1; F2R; FGD5; GPR21; NRP1; PLXNA2; PREX2; PTPRN2; RABGAP1; RASGRP2; RASIP1; RGS5; S1PR1; SLIT2; SPRY1; THY1
GO:0050817	coagulation	2.10	1.70e-03	2.47e-02	19/194	A2M; CAV1; CD34; ENPP4; F2RL3; F2R; FYN; GNG2; HBB; ITGB3; MMRN1; NOS3; P2RY1; PEAR1; SELP; TFPI; THBD; TRPC6; VWF
GO:0043270	positive regulation of ion transport	2.06	2.70e-03	3.60e-02	18/187	ABCB1; ADCYAP1R1; APLNR; AVPR1A; CAV1; F2RL3; F2R; GJC2; KCNJ2; LRRC55; P2RY1; PDGFRB; RAMP3; SCN4B; SLC6A1; TESC; THY1; TRPC6
GO:0003012	muscle system process	2.03	1.56e-04	3.68e-03	30/317	ACTC1; ADRA1B; ARHGAP42; BDKRB2; CALCRL; CASQ2; CAV1; CLIC2; DYSF; EDNRB; F2R; GJA5; HRC; ITGA1; KCNA5; KCNJ2; KCNJ8; KCNN2; MEF2C; MYH11; MYL4; MYOCD; MYOM1; NOS3; P2RY1; PLN; SCN4A; SCN4B; SGCA; TNFRSF1B
GO:0050878	regulation of body fluid levels	2.03	2.08e-04	4.46e-03	29/307	A2M; ADCY4; APLNR; AQP1; CAV1; CD34; EDNRB; ENPP4; F2RL3; F2R; FLI1; FYN; GJA5; GNG2; HBB; HEG1; ITGB3; MMRN1; NOS3; NPR1; P2RY1; PEAR1; SELP; TFPI; THBD; TRPC6; VEGFA; VIP; VWF
GO:0048880	sensory system development	2.02	1.62e-03	2.40e-02	21/223	ARHGEF15; COL4A1; DLL4; GDF3; JAG1; MAF; MFRP; MYOM1; NES; NRP1; PDGFRB; PRDM1; PTPRM; RHOJ; TBX2; TGFBR2; THY1; UNC45B; VEGFA; ZEB1; ZEB2
GO:0034765	regulation of ion transmembrane transport	2.01	1.39e-04	3.65e-03	31/330	ABCB1; APLNR; CASQ2; CAV1; CLIC2; CLIC5; CRHBP; DYSF; F2RL3; F2R; FYN; GEM; GJA5; GJC2; HECW2; HRC; KCNA5; KCNJ2; KCNJ8; KCNN2; LRRC55; MEF2C; PLN; RAMP3; REM1; SCN4A; SCN4B; SCN9A; TESC; THY1; TRPC6

Summary:
Factor	1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	19	20
Signif_GO_terms	0	0	12	49	106	0	4	27	11	0	13	0	67	59	6	94	2	63	4	60

5 DEG Interpretation

In GSFA, differential expression analysis can be performed based on the LFSR method. Here we evaluate the specific downstream genes affected by the perturbations detected by GSFA.

We also performed several other differential expression methods for comparison, including Welch's t-test.

5.1 Number of DEGs detected by different methods

Number of DEGs detected by GSFA under each mutation:
KO	TP53_LOF	TP53_mis	CDH1_LOF	CDH1_mis	GATA3_LOF
Num_genes	772	1610	1633	0	377
KO	GATA3_mis	MAP3K1_LOF	MAP3K1_mis	PIK3CA_LOF	PIK3CA_mis
Num_genes	0	0	0	0	1141

Number of DEGs detected under each perturbation using different methods:

5.2 Perturbation effects on marker genes

To better understand the functions of these mutations, we examined their effects on marker genes for cell proliferation and T cell activation/resting states.

5.2.1 GSFA

Here are the summarized effects of perturbations on marker genes estimated by GSFA.

As we can see, TP53 loss of function/missense mutations have positive effects on cell proliferation, while CDH1 loss of function and PIK2CA missense mutations have negative effects on cell proliferation.

CDH1 LOF is also positively associated with T cell markers (for both activation and resting states).

5.3 GO enrichment in DEGs

We further examine these DEGs for enrichment of relevant biological processes through GO enrichment analysis.

Foreground genes: Genes w/ GSFA LFSR < 0.05 under each perturbation;
Background genes: all 10k genes used in GSFA;
Statistical test: hypergeometric test (over-representation test);
Gene sets: Gene ontology "Biological Process" (non-redundant).

GO terms that passed over-representation test fold change \(\geq\) 2 and q value \(<\) 0.05:

TP53_LOF : 62 significant GO terms

GeneSet	description	enrichRatio	pValue	FDR	GeneRatio	geneSymbols
GO:0051383	kinetochore organization	12.00	5.80e-11	1.75e-09	10/11	CDT1; CENPA; CENPE; CENPF; CENPK; CENPN; CENPW; NDC80; NUF2; SMC4
GO:0061641	CENP-A containing chromatin organization	10.20	1.31e-09	3.33e-08	10/13	KNL1; CENPA; CENPI; CENPK; CENPM; CENPN; CENPW; HJURP; CENPU; OIP5
GO:0034502	protein localization to chromosome	9.62	4.51e-14	1.67e-12	16/22	AURKB; BRCA2; BUB1B; KNL1; CDCA5; CDK1; CDT1; CENPA; ESCO2; EZH2; HASPIN; MTBP; NDC80; PLK1; RAD21; TTK
GO:0050000	chromosome localization	9.31	4.44e-16	1.81e-14	19/27	CCNB1; CDCA5; CDCA8; CDT1; CENPE; CENPF; CEP55; CHMP4C; DLGAP5; FAM83D; KIF14; KIF18A; KIF2C; KIFC1; NDC80; NUF2; PSRC1; RRS1; SPAG5
GO:0036297	interstrand cross-link repair	8.82	3.83e-07	8.20e-06	8/12	EME1; FANCA; FANCB; FANCE; FANCI; RAD51AP1; RAD51; UBE2T
GO:0006260	DNA replication	7.99	0.00e+00	0.00e+00	58/96	ATAD5; BARD1; BLM; BRCA1; BRCA2; BRIP1; TICRR; RMI2; MCMDC2; CCNA2; CCNE1; CCNE2; CDC45; CDC6; CDC7; CDK1; CDT1; CHAF1B; CHEK1; CHTF18; CLSPN; DBF4; DDX11; DNA2; DSCC1; DTL; E2F7; E2F8; EME1; ESCO2; EXO1; FBXO5; FEN1; GINS1; GINS2; GINS4; GMNN; PCLAF; MCM10; MCM2; MCM4; MCM5; MCM6; MCM7; TONSL; ORC1; PIF1; POLD1; POLE2; POLQ; RAD51; RECQL4; RFC4; RNASEH2A; RRM2; ALYREF; TOP1MT; WDHD1
GO:0007059	chromosome segregation	7.83	0.00e+00	0.00e+00	74/125	AURKB; BIRC5; BLM; BRCA1; BRIP1; BUB1B; BUB1; KNSTRN; RMI2; MCMDC2; KNL1; CCNB1; CCNE1; CCNE2; CDC20; CDC6; CDCA5; CDCA8; CDT1; CENPE; CENPF; CENPN; CENPW; CEP55; CHMP4C; DDX11; DLGAP5; DSCC1; ECT2; EME1; ESCO2; ESPL1; FAM83D; FBXO5; FEN1; HASPIN; HJURP; KIF14; KIF18A; KIF18B; KIF23; KIF2C; KIF4A; KIFC1; MAD2L1; MKI67; NCAPD2; NCAPG; NCAPH; NDC80; NEK2; NUF2; NUSAP1; OIP5; PLK1; PRC1; PSRC1; PTTG1; RACGAP1; RAD21; RRS1; SGO1; SGO2; SKA1; SKA2; SKA3; SMC4; SPAG5; TACC3; NDC1; TOP2A; TRIP13; TTK; ZWINT
GO:1902850	microtubule cytoskeleton organization involved in mitosis	7.74	0.00e+00	0.00e+00	31/53	AURKA; AURKB; SAPCD2; CCNB1; CDC20; CENPA; CENPE; CHMP4C; ESPL1; GPSM2; CEP126; KIF11; KIF23; KIF4A; KIFC1; MYBL2; NDC80; NEK2; NUF2; NUSAP1; PLK1; POC1A; PRC1; PSRC1; RACGAP1; STIL; STMN1; TACC3; TPX2; TTK; WDR62
GO:0045023	G0 to G1 transition	7.12	1.56e-05	2.76e-04	7/13	BRCA1; CDC7; CHEK1; E2F1; EZH2; RAD51; RRM2
GO:0000075	cell cycle checkpoint	7.07	0.00e+00	0.00e+00	39/73	AURKA; AURKB; BLM; BRCA1; BRIP1; BUB1B; BUB1; TICRR; CCNB1; CDC20; CDC25C; CDC45; CDC6; CDK1; CDT1; CENPF; CHEK1; CHMP4C; CLSPN; DNA2; DTL; E2F1; E2F7; E2F8; EME1; GTSE1; H2AFX; KNTC1; MAD2L1; NDC80; NEK11; ORC1; PLK1; PRKDC; TOP2A; TRIP13; TTK; WDR76; ZWINT
GO:0007051	spindle organization	6.81	0.00e+00	0.00e+00	34/66	ASPM; AURKA; AURKB; KNSTRN; AUNIP; CCNB1; CDC20; CENPE; CHMP4C; ESPL1; FBXO5; GPSM2; WASHC5; CEP126; KIF11; KIF23; KIF4A; KIFC1; MYBL2; NDC80; NEK2; NUF2; PLK1; POC1A; PRC1; PSRC1; RACGAP1; SPAG5; STIL; STMN1; TACC3; TPX2; TTK; WDR62
GO:0032200	telomere organization	6.61	1.77e-10	4.98e-09	16/32	AURKB; BLM; BRCA2; CCNE1; CCNE2; DNA2; EXO1; FEN1; MYC; NEK2; PIF1; POLD1; PRKDC; RAD51; RECQL4; RFC4
GO:0006301	postreplication repair	6.61	1.13e-04	1.88e-03	6/12	BRCA1; DTL; PCLAF; POLD1; POLE2; RFC4
GO:0006302	double-strand break repair	6.52	0.00e+00	0.00e+00	35/71	BARD1; BLM; BRCA1; BRCA2; BRIP1; PARPBP; RMI2; AUNIP; MCMDC2; CDC45; CDC7; CDCA5; CHEK1; DDX11; DEK; DNA2; EME1; ESCO2; EXO1; FANCB; FEN1; FOXM1; GINS2; GINS4; H2AFX; TONSL; POLQ; PRKDC; RAD21; RAD51AP1; RAD51; RAD54B; RAD54L; RECQL4; TRIP13
GO:0000910	cytokinesis	6.28	1.11e-16	5.02e-15	28/59	ANLN; AURKA; AURKB; BRCA2; CDC25B; CDC6; CDT1; CENPA; CEP55; CHMP4C; CIT; CKAP2; CSPP1; E2F7; E2F8; ECT2; ESPL1; WASHC5; KIF14; KIF20A; KIF23; KIF4A; NUSAP1; PLK1; PRC1; RACGAP1; SEPT3; STMN1
GO:0000726	non-recombinational repair	6.23	1.34e-05	2.47e-04	8/17	BARD1; BLM; BRCA1; AUNIP; DEK; H2AFX; POLQ; PRKDC
GO:0071166	ribonucleoprotein complex localization	6.11	1.97e-04	3.02e-03	6/13	DDX39A; HHEX; NUP210; RRS1; ALYREF; NDC1
GO:0044839	cell cycle G2/M phase transition	6.06	0.00e+00	0.00e+00	38/83	ATAD5; AURKA; AURKB; BLM; BRCA1; TICRR; CCNA2; CCNB1; CCNB2; CDC25A; CDC25B; CDC25C; CDC6; CDC7; CDK1; CENPF; CHEK1; CHMP4C; CIT; CLSPN; DTL; FBXO5; FOXM1; GTSE1; HMMR; KIF14; MELK; NEK10; NEK2; ORC1; PCM1; PKMYT1; PLK1; PLK4; RAD21; RECQL4; SKP2; TPX2
GO:0071103	DNA conformation change	5.94	0.00e+00	0.00e+00	44/98	ASF1B; BLM; BRIP1; KNL1; CCNB1; CDC45; CDCA5; CDK1; CENPA; CENPI; CENPK; CENPM; CENPN; CENPW; CHAF1B; DDX11; DNA2; GINS1; GINS2; GINS4; H2AFX; HELLS; HHEX; HJURP; HMGB2; MCM2; MCM4; MCM6; MCM7; CENPU; NCAPD2; NCAPG2; NCAPG; NCAPH; NUSAP1; OIP5; PIF1; RAD51; RAD54B; RAD54L; RECQL4; SMC4; TOP1MT; TOP2A
GO:0031023	microtubule organizing center organization	5.85	5.24e-11	1.64e-09	19/43	AURKA; BRCA1; BRCA2; CCNF; CDK1; CHEK1; CHMP4C; CNTLN; PCLAF; KIF11; NEK2; PCM1; PLK1; PLK4; POC1A; SGO1; STIL; TRIM37; WDR62
GO:0051653	spindle localization	5.79	8.50e-05	1.44e-03	7/16	ASPM; SAPCD2; CENPA; ESPL1; GPSM2; NDC80; NUSAP1
GO:0001578	microtubule bundle formation	5.70	8.89e-14	3.15e-12	25/58	ARMC4; CFAP43; DRC1; CFAP206; CFAP157; CCDC103; CCDC114; CCDC65; DNAH7; DNAI2; DNAJB13; HYDIN; KIF20A; LRGUK; LRRC49; DNAAF1; LRRC6; NCKAP5; PLK1; PRC1; PSRC1; RSPH1; RSPH4A; TEKT2; TPPP3
GO:0006284	base-excision repair	5.67	3.22e-04	4.86e-03	6/14	DNA2; FEN1; NEIL3; POLD1; POLQ; RECQL4
GO:0044772	mitotic cell cycle phase transition	5.65	0.00e+00	0.00e+00	82/192	ANLN; ATAD5; AURKA; AURKB; BLM; BRCA1; BUB1B; BUB1; TICRR; CCNA2; CCNB1; CCNB2; CCNE1; CCNE2; CDC20; CDC25A; CDC25B; CDC25C; CDC45; CDC6; CDC7; CDCA5; CDK1; CDKN2C; CDKN2D; CDKN3; CDT1; CENPE; CENPF; CHMP4C; CIT; CKS1B; CKS2; CLSPN; DBF4; DLGAP5; DTL; E2F1; E2F7; E2F8; ESPL1; EZH2; FBXO5; FOXM1; GMNN; GTSE1; HMMR; IQGAP3; KIF14; KNTC1; MAD2L1; MCM10; MCM2; MCM4; MCM5; MCM6; MCM7; MELK; MTBP; MYC; NDC80; NEK11; NEK2; ORC1; PCM1; PKMYT1; PLK1; PLK4; POLE2; PRKDC; RAD21; RBL1; RECQL4; RRM2; SKP2; TACC3; TPX2; TRIP13; TTK; TYMS; UBE2C; UBE2S
GO:0021591	ventricular system development	5.51	1.23e-03	1.67e-02	5/12	ARMC4; AK8; CENPF; HYDIN; NME5
GO:0001539	cilium or flagellum-dependent cell motility	5.41	1.54e-05	2.76e-04	9/22	DRC1; CCDC65; DNAH6; DNAH7; SPEF1; TEKT1; TEKT2; TEKT3; CFAP57
GO:0048285	organelle fission	5.27	0.00e+00	0.00e+00	86/216	ANLN; ASPM; AURKA; AURKB; BLM; BRCA2; BRIP1; BUB1B; BUB1; KNSTRN; MCMDC2; CCNA2; CCNB1; CCNB2; CCNE1; CCNE2; CCNF; CCNO; CDC20; CDC25B; CDC25C; CDC6; CDCA5; CDCA8; CDT1; CENPE; CENPF; CEP55; CHEK1; CHMP4C; CKS2; DLGAP5; DSCC1; EME1; ESPL1; MTFR2; FANCA; FBXO5; HASPIN; WASHC5; KIF11; KIF14; KIF18A; KIF18B; KIF23; KIF2C; KIF4A; KIFC1; KNTC1; MAD2L1; MKI67; MND1; MTBP; MTFR1; MYBL1; MYBL2; NCAPD2; NCAPG; NCAPH; NDC80; NEK2; NUF2; NUSAP1; PKMYT1; PLK1; PRC1; PSRC1; PTTG1; RACGAP1; RAD21; RAD51; RAD54B; RRS1; SGO1; SGO2; SMC4; SPAG5; TACC3; NDC1; TOP2A; TPX2; TRIP13; TTK; UBE2C; UBE2S; ZWINT
GO:1901987	regulation of cell cycle phase transition	5.15	0.00e+00	0.00e+00	58/149	ANLN; ATAD5; AURKA; AURKB; BLM; BRCA1; BUB1B; BUB1; TICRR; CCNB1; CCNE1; CDC20; CDC25A; CDC25B; CDC25C; CDC45; CDC6; CDC7; CDCA5; CDK1; CDKN2D; CDT1; CENPE; CENPF; CHEK1; CHMP4C; CLSPN; DLGAP5; DTL; E2F1; E2F7; E2F8; ESPL1; EZH2; FAM83D; FBXO5; GTSE1; HMMR; KIF14; KNTC1; MAD2L1; MTBP; NDC80; NEK10; NEK11; NEK2; ORC1; PCM1; PLK1; PLK4; PRKDC; RAD21; RBL1; RECQL4; TPX2; TRIP13; TTK; UBE2C
GO:0010948	negative regulation of cell cycle process	5.12	0.00e+00	0.00e+00	43/111	AURKA; AURKB; BLM; BRCA1; BUB1B; BUB1; TICRR; CCNB1; CCNF; CDC20; CDC25C; CDC6; CDC7; CDK1; CDKN2D; CDT1; CENPF; CHEK1; CHMP4C; CLSPN; DTL; E2F1; E2F7; E2F8; ESPL1; EZH2; FBXO5; GTSE1; MAD2L1; MTBP; NDC80; NEK2; ORC1; PLK1; PRKDC; PTTG1; RAD21; RAD51; RBL1; RRM2; TRIM37; TRIP13; TTK
GO:0044843	cell cycle G1/S phase transition	4.98	0.00e+00	0.00e+00	41/109	AURKA; CCNA2; CCNB1; CCNE1; CCNE2; CDC25A; CDC25C; CDC45; CDC6; CDC7; CDK1; CDKN2C; CDKN2D; CDKN3; CDT1; DBF4; E2F1; E2F7; E2F8; EZH2; FAM83D; FBXO5; GMNN; GTSE1; IQGAP3; KIF14; MCM10; MCM2; MCM4; MCM5; MCM6; MCM7; MTBP; MYC; ORC1; POLE2; PRKDC; RBL1; RRM2; SKP2; TYMS
GO:0007018	microtubule-based movement	4.96	0.00e+00	0.00e+00	48/128	ARMC4; DRC1; MAATS1; CFAP206; CCDC103; CCDC114; CFAP53; CCDC65; CENPE; CNIH2; DLGAP5; DNAH12; DNAH6; DNAH7; DNAH9; DNAI2; HYDIN; KIF11; KIF14; KIF15; KIF17; KIF18A; KIF18B; KIF20A; KIF21A; KIF23; KIF24; KIF2C; KIF4A; KIF6; KIFC1; KIFC2; DNAAF1; LRRC6; MAK; NME5; CFAP221; PCM1; RACGAP1; ROPN1L; RSPH4A; SPA17; TEKT1; TEKT2; TEKT3; WDR34; WDR63; WDR78
GO:1904029	regulation of cyclin-dependent protein kinase activity	4.81	1.09e-09	2.87e-08	20/55	BLM; CCNA2; CCNB1; CCNB2; CCNE1; CCNE2; CCNF; CCNO; CDC25A; CDC25C; CDC6; CDKN2C; CDKN2D; CDKN3; CKS1B; CKS2; HHEX; PKMYT1; PLK1; PSRC1
GO:0044380	protein localization to cytoskeleton	4.81	1.25e-04	2.04e-03	8/22	ANLN; AURKA; FAM83D; FAM83H; PCM1; SPAG5; STIL; TTK
GO:0045930	negative regulation of mitotic cell cycle	4.80	0.00e+00	0.00e+00	41/113	AURKA; AURKB; BLM; BRCA1; BUB1B; BUB1; TICRR; CCNB1; CDC20; CDC25C; CDC6; CDK1; CDT1; CENPF; CHEK1; CHMP4C; CLSPN; E2F1; E2F7; E2F8; EME1; EZH2; FBXO5; GTSE1; KNTC1; MAD2L1; MTBP; NDC80; NEK11; NKX3-1; ORC1; PLK1; PRKDC; PTTG1; RAD21; RBL1; SCRIB; TOP2A; TRIP13; TTK; ZWINT
GO:0006310	DNA recombination	4.76	2.22e-16	9.51e-15	36/100	ATAD5; BLM; BRCA1; BRCA2; BRIP1; PARPBP; RMI2; AUNIP; MCMDC2; CDC45; CDC7; CHEK1; EME1; EXO1; FANCB; FEN1; GINS2; GINS4; H2AFX; HMGB2; KPNA2; MND1; TONSL; PIF1; POLQ; PRKDC; RAD21; RAD51AP1; RAD51; RAD54B; RAD54L; RECQL4; TFRC; ALYREF; TOP2A; TRIP13
GO:0033044	regulation of chromosome organization	4.58	1.22e-15	4.73e-14	36/104	ATAD2; AURKB; BRCA1; BUB1B; BUB1; RMI2; CCNB1; CDC20; CDC45; CDC6; CDCA5; CDT1; CENPE; CENPF; CHEK1; DDX11; DLGAP5; DNMT3B; ESPL1; FBXO5; FEN1; MAD2L1; MCM2; MKI67; MYC; NDC80; NEK2; PHF19; PIF1; PLK1; PTTG1; RAD21; TACC3; TOP2A; TRIP13; TTK
GO:0042770	signal transduction in response to DNA damage	4.58	1.86e-08	4.33e-07	18/52	ATAD5; AURKA; BRCA1; BRCA2; CCNB1; CDC25C; CDK1; CHEK1; DTL; E2F1; E2F7; E2F8; FOXM1; GTSE1; NDRG1; PLK1; PMAIP1; PRKDC
GO:0051321	meiotic cell cycle	4.58	0.00e+00	0.00e+00	45/130	ASPM; AURKA; BLM; BRCA2; BRIP1; BUB1B; BUB1; MCMDC2; CCNE1; CCNE2; CDC20; CDC25A; CDC25B; CDC25C; CKS2; EME1; ESPL1; EXO1; FANCA; FBXO5; H2AFX; WASHC5; KIF18A; MND1; MYBL1; NCAPD2; NCAPH; NEK2; NUF2; PKMYT1; PLK1; PRKACB; PTTG1; RAD21; RAD51; RAD54B; RAD54L; RSPH1; SGO1; SGO2; SMC4; NDC1; TOP2A; TRIP13; TTK
GO:0015949	nucleobase-containing small molecule interconversion	4.41	3.85e-03	4.74e-02	5/15	AK8; CTPS1; GLRX; NME2; TYMS
GO:0071824	protein-DNA complex subunit organization	4.03	6.81e-10	1.85e-08	25/82	ANP32E; ASF1B; MCMDC2; KNL1; CDC45; CDT1; CENPA; CENPE; CENPF; CENPI; CENPK; CENPM; CENPN; CENPW; CHAF1B; GMNN; H2AFX; HELLS; HJURP; HMGB2; MCM2; CENPU; MYC; OIP5; RAD51
GO:0071897	DNA biosynthetic process	3.97	2.27e-07	5.00e-06	18/60	AURKB; BLM; CDKN2D; CENPF; CHTF18; DSCC1; DTL; PCLAF; LIN9; MYC; NEK2; PIF1; POLD1; POLE2; POLQ; RFC4; TK1; TYMS
GO:0006338	chromatin remodeling	3.97	2.34e-06	4.75e-05	15/50	ANP32E; KNL1; CENPA; CENPI; CENPK; CENPM; CENPN; CENPW; CHEK1; HELLS; HJURP; HMGB2; CENPU; MYC; OIP5
GO:2001020	regulation of response to DNA damage stimulus	3.90	6.82e-09	1.68e-07	23/78	ATAD5; BLM; BRCA1; DDIAS; PARPBP; RMI2; AUNIP; CDKN2D; CHEK1; DDX11; DEK; ELL3; FANCB; FBXO5; FOXM1; H2AFX; MYC; NKX3-1; PMAIP1; POLQ; RAD51AP1; RAD51; WDR76
GO:0045787	positive regulation of cell cycle	3.81	0.00e+00	0.00e+00	55/191	ATAD5; AURKA; AURKB; BRCA1; BRCA2; CCNA2; CCNB1; CCNB2; CCNE1; CCNE2; CCNF; CCNO; CDC25A; CDC25B; CDC25C; CDC45; CDC6; CDC7; CDCA5; CDK1; CDT1; CHEK1; CIT; CKS1B; CKS2; CSPP1; DDX11; DLGAP5; DTL; E2F1; E2F7; E2F8; ECT2; ESPL1; EZH2; FAM83D; FBXO5; FEN1; GPSM2; GTSE1; KIF14; KIF23; MAD2L1; MTBP; NDC80; NKX3-1; NUSAP1; PLK4; POC1A; PSRC1; RACGAP1; RAD21; RECQL4; SPAG5; UBE2C
GO:0032886	regulation of microtubule-based process	3.74	1.03e-10	3.00e-09	30/106	ARMC4; AURKA; BRCA1; DRC1; CCDC65; CCNF; CHEK1; CHMP4C; CKAP2; CNIH2; GPSM2; KIF11; KIF18A; DNAAF1; NEK2; PLK1; PLK4; POC1A; PRKAA2; PSRC1; SKA1; SKA2; SKA3; SPAG5; SPEF1; STIL; STMN1; TACC3; TPX2; TRIM37
GO:0006997	nucleus organization	3.61	5.61e-04	8.16e-03	9/33	CCNB1; CCNB2; CDK1; CEP55; CHMP4C; GOLM1; HMGB2; PLK1; NDC1
GO:0051052	regulation of DNA metabolic process	3.60	2.95e-13	9.61e-12	40/147	ATAD5; AURKB; BLM; BRCA1; BRCA2; PARPBP; TICRR; RMI2; AUNIP; CCNA2; CDC6; CDC7; CDK1; CDT1; CHEK1; CHTF18; DBF4; DDX11; DEK; DNA2; DSCC1; E2F7; E2F8; ESCO2; FANCB; FBXO5; FOXM1; GMNN; H2AFX; KPNA2; MYC; NEK2; PIF1; POLQ; RAD51AP1; RAD51; RECQL4; RFC4; TFRC; ALYREF
GO:0031109	microtubule polymerization or depolymerization	3.54	1.10e-05	2.19e-04	15/56	CKAP2; FBXO5; KIF14; KIF18A; KIF18B; KIF24; KIF2C; NCKAP5; PSRC1; SKA1; SKA2; SKA3; SPEF1; STMN1; TPPP3
GO:0044782	cilium organization	3.54	1.39e-13	4.71e-12	42/157	ARMC4; CFAP43; CFAP126; DRC1; CATIP; CFAP206; CFAP157; CCDC103; CCDC114; CFAP53; CCDC13; CCDC65; CCNO; CDK1; DNAH7; DNAI2; DNAJB13; HYDIN; IQUB; CEP126; KIF17; KIF24; LRGUK; LRRC49; DNAAF1; LRRC6; MAK; NEK2; NME5; NPHP1; CFAP221; PCM1; PLK1; PLK4; POC1A; RSPH1; RSPH4A; SEPT3; TEKT1; TEKT2; TEKT3; WDR34
GO:0072331	signal transduction by p53 class mediator	3.42	1.93e-07	4.37e-06	22/85	ATAD5; AURKA; AURKB; BOP1; BRCA1; BRCA2; CCNB1; CDC25C; CDK1; CHEK1; E2F1; E2F2; E2F7; E2F8; ELL3; FOXM1; GTSE1; NDRG1; PMAIP1; PYCARD; RRS1; TPX2
GO:0071826	ribonucleoprotein complex subunit organization	3.40	8.97e-04	1.28e-02	9/35	BOP1; TICRR; AGO2; EIF3H; MTERF3; PIH1D2; PRKAA2; PSIP1; RRS1
GO:0006333	chromatin assembly or disassembly	3.36	1.18e-05	2.26e-04	16/63	ASF1B; KNL1; CENPA; CENPI; CENPK; CENPM; CENPN; CENPW; CHAF1B; H2AFX; HELLS; HJURP; HMGB2; MCM2; CENPU; OIP5
GO:0051302	regulation of cell division	3.17	4.63e-07	9.67e-06	23/96	ASPM; AURKA; AURKB; BLM; BRCA2; CDC25B; CDC6; CHMP4C; CIT; CSPP1; E2F7; E2F8; ECT2; KIF14; KIF18B; KIF20A; KIF23; MYC; NKX3-1; PLK1; PRC1; RACGAP1; RBL1
GO:0090305	nucleic acid phosphodiester bond hydrolysis	3.09	1.19e-05	2.26e-04	18/77	ATAD5; BOP1; DNA2; AGO2; EME1; EXO1; EXOSC4; FEN1; HMGB2; RIDA; ISG20; LACTB2; REXO5; POLD1; POP1; RFC4; RNASEH2A; RRS1
GO:0022613	ribonucleoprotein complex biogenesis	3.05	3.87e-04	5.72e-03	12/52	BOP1; TICRR; DCAF13; AGO2; EIF3H; EXOSC4; ISG20; MTERF3; PIH1D2; PRKAA2; PSIP1; RRS1
GO:0031503	protein-containing complex localization	2.94	7.02e-05	1.22e-03	16/72	BIRC5; CNIH2; DDX39A; GPC4; HASPIN; HHEX; KIF17; MAK; NUP210; PCM1; RRS1; SCRIB; STX1B; ALYREF; NDC1; WDR34
GO:0010639	negative regulation of organelle organization	2.84	1.02e-08	2.43e-07	35/163	ATAD2; AURKB; BRCA1; BUB1B; BUB1; ARPIN; CCNB1; CCNF; CDC20; CDT1; CENPF; CHEK1; CKAP2; DLC1; DNMT3B; ESPL1; FBXO5; MAD2L1; MAK; MCM2; MTBP; NDC80; NEK2; PIF1; PLEKHH2; PLK1; PTTG1; RAD21; SPEF1; STMN1; TMSB15A; TMSB15B; TOP2A; TRIM37; TRIP13; TTK
GO:0022406	membrane docking	2.80	1.45e-03	1.94e-02	11/52	CDK1; KIF24; NEK2; NPHP1; PCM1; PLK1; PLK4; SNPH; STX1B; SYTL2; TSNARE1
GO:1903320	regulation of protein modification by small protein conjugation or removal	2.46	1.97e-03	2.51e-02	13/70	BRCA1; CDC20B; CDC20; FANCI; FBXO5; MAD2L1; MTBP; PLK1; RIPK2; SKP2; UBE2C; UBE2S; VPS28
GO:0007050	cell cycle arrest	2.43	1.62e-04	2.53e-03	20/109	AURKA; BARD1; BRCA1; DDIAS; CCNB1; CDC25C; CDK1; CDKN2C; CDKN2D; CDKN3; E2F1; E2F7; E2F8; FOXM1; GTSE1; MTBP; MYC; NKX3-1; PRKAA2; PRR11
GO:0007292	female gamete generation	2.34	2.14e-03	2.68e-02	14/79	ASPM; AURKA; BRCA2; MCMDC2; CCNB1; CDC25B; FBXO5; WASHC5; NCAPH; PLK1; TOP2A; TRIP13; TTK; YBX2
GO:0010498	proteasomal protein catabolic process	2.15	1.14e-03	1.57e-02	19/117	AURKA; AURKB; BUB1B; CCNB1; CCNF; CDC20; CDK1; FBXL6; FBXO5; KIF14; MAD2L1; PBK; PLK1; PMAIP1; PTTG1; SHARPIN; SKP2; UBE2C; UBE2S

TP53_mis : 44 significant GO terms

GeneSet	description	enrichRatio	pValue	FDR	GeneRatio	geneSymbols
GO:0051383	kinetochore organization	5.58	1.19e-07	4.02e-06	10/11	CDT1; CENPA; CENPE; CENPF; CENPK; CENPN; CENPW; NDC80; NUF2; SMC4
GO:0034502	protein localization to chromosome	5.02	2.21e-11	1.28e-09	18/22	AURKB; BRCA2; BUB1B; KNL1; CDCA5; CDK1; CDT1; CENPA; ESCO2; ESR1; EZH2; HASPIN; MTBP; NDC80; PARP3; PLK1; RAD21; TTK
GO:0061641	CENP-A containing chromatin organization	4.72	2.26e-06	6.58e-05	10/13	KNL1; CENPA; CENPI; CENPK; CENPM; CENPN; CENPW; HJURP; CENPU; OIP5
GO:0050000	chromosome localization	4.09	6.21e-09	2.66e-07	18/27	CCNB1; CDCA5; CDCA8; CDT1; CENPE; CENPF; CEP55; DLGAP5; FAM83D; KIF14; KIF18A; KIF2C; KIFC1; NDC80; NUF2; PSRC1; RRS1; SPAG5
GO:0036297	interstrand cross-link repair	4.09	1.29e-04	3.01e-03	8/12	EME1; FANCA; FANCB; FANCE; FANCI; RAD51AP1; RAD51; UBE2T
GO:0007059	chromosome segregation	3.83	0.00e+00	0.00e+00	78/125	AURKB; BIRC5; BLM; BRCA1; BRIP1; BUB1B; BUB1; KNSTRN; RMI2; M1AP; MCMDC2; C9orf84; KNL1; CCNB1; CCNE1; CCNE2; CDC20; CDC6; CDCA5; CDCA8; CDT1; CENPE; CENPF; CENPN; CENPW; CEP55; DDX11; DLGAP5; DSCC1; ECT2; EME1; ESCO2; ESPL1; FAM83D; FBXO5; FEN1; HASPIN; HJURP; KIF14; KIF18A; KIF18B; KIF23; KIF2C; KIF4A; KIFC1; MAD2L1; MKI67; NCAPD2; NCAPG; NCAPH; NDC80; NEK2; NUF2; NUSAP1; OIP5; PLK1; PRC1; PSRC1; PTTG1; RACGAP1; RAD21; RGS14; RRS1; SGO1; SGO2; SKA1; SKA2; SKA3; SMC1B; SMC4; SPAG5; SYCP1; TACC3; NDC1; TOP2A; TRIP13; TTK; ZWINT
GO:0006260	DNA replication	3.77	0.00e+00	0.00e+00	59/96	ATAD5; BARD1; BLM; BRCA1; BRCA2; BRIP1; TICRR; RMI2; MCMDC2; CCNA2; CCNE1; CCNE2; CDC45; CDC6; CDC7; CDK1; CDT1; CHAF1B; CHEK1; CHTF18; CLSPN; DBF4; DDX11; DNA2; DSCC1; DTL; E2F7; E2F8; EGFR; EME1; ESCO2; EXO1; FBXO5; FEN1; GINS1; GINS2; GINS4; GMNN; PCLAF; MCM10; MCM2; MCM4; MCM5; MCM6; MCM7; TONSL; NT5M; ORC1; PIF1; POLD1; POLE2; POLQ; RAD51; RECQL4; RFC4; RNASEH2A; RRM2; ALYREF; WDHD1
GO:1902850	microtubule cytoskeleton organization involved in mitosis	3.59	3.09e-12	2.51e-10	31/53	AURKA; AURKB; SAPCD2; CCNB1; CDC20; CENPA; CENPE; ESPL1; GPSM2; CEP126; KIF11; KIF23; KIF4A; KIFC1; MYBL2; NDC80; NEK2; NUF2; NUSAP1; PARP3; PLK1; POC1A; PRC1; PSRC1; RACGAP1; STIL; STMN1; TACC3; TPX2; TTK; WDR62
GO:0000075	cell cycle checkpoint	3.36	4.26e-14	4.96e-12	40/73	AURKA; AURKB; BLM; BRCA1; BRIP1; BUB1B; BUB1; TICRR; CCNB1; CCND1; CDC20; CDC25C; CDC45; CDC6; CDK1; CDT1; CENPF; CHEK1; CLSPN; DNA2; DTL; E2F1; E2F7; E2F8; EME1; GTSE1; H2AFX; KNTC1; MAD2L1; NDC80; NEK11; ORC1; PLK1; PRKDC; SOX11; TOP2A; TRIP13; TTK; WDR76; ZWINT
GO:0001539	cilium or flagellum-dependent cell motility	3.35	4.32e-05	1.13e-03	12/22	DRC1; CCDC39; CCDC65; DNAH11; DNAH6; DNAH7; SPATA4; SPEF1; TEKT1; TEKT2; TEKT3; CFAP57
GO:0045023	G0 to G1 transition	3.31	2.07e-03	3.44e-02	7/13	BRCA1; CDC7; CHEK1; E2F1; EZH2; RAD51; RRM2
GO:0015949	nucleobase-containing small molecule interconversion	3.27	1.06e-03	1.92e-02	8/15	AK4; AK8; CTPS1; GSR; GUK1; NME1; NME2; TYMS
GO:0032200	telomere organization	3.26	1.75e-06	5.27e-05	17/32	AURKB; BLM; BRCA2; CCNE1; CCNE2; DNA2; EXO1; FEN1; HMBOX1; NEK2; PARP3; PIF1; POLD1; PRKDC; RAD51; RECQL4; RFC4
GO:0007051	spindle organization	3.26	6.05e-12	4.10e-10	35/66	ASPM; AURKA; AURKB; KNSTRN; AUNIP; CCNB1; CDC20; CENPE; ESPL1; FBXO5; GPSM2; WASHC5; CEP126; KIF11; KIF23; KIF4A; KIFC1; MYBL2; NDC80; NEK2; NUF2; PARP3; PLK1; POC1A; PRC1; PSRC1; RACGAP1; RGS14; SPAG5; STIL; STMN1; TACC3; TPX2; TTK; WDR62
GO:0071103	DNA conformation change	3.13	1.33e-15	2.17e-13	50/98	ASF1B; BLM; BRIP1; M1AP; KNL1; CCNB1; CDC45; CDCA5; CDK1; CENPA; CENPI; CENPK; CENPM; CENPN; CENPW; CHAF1B; CHD5; DDX11; DNA2; GINS1; GINS2; GINS4; GPER1; H2AFX; HELLS; HHEX; HJURP; HMGB2; HMGB3; MCM2; MCM4; MCM6; MCM7; CENPU; NAP1L5; NCAPD2; NCAPG2; NCAPG; NCAPH; NUSAP1; OIP5; PIF1; RAD51; RAD54B; RAD54L; RECQL4; SMC4; SYCP1; SYCP3; TOP2A
GO:0006302	double-strand break repair	3.11	1.70e-11	1.06e-09	36/71	BARD1; BLM; BRCA1; BRCA2; BRIP1; PARPBP; RMI2; AUNIP; MCMDC2; CDC45; CDC7; CDCA5; CHEK1; DDX11; DEK; DNA2; EME1; ESCO2; EXO1; FANCB; FEN1; FOXM1; GINS2; GINS4; H2AFX; TONSL; PARP3; POLQ; PRKDC; RAD21; RAD51AP1; RAD51; RAD54B; RAD54L; RECQL4; TRIP13
GO:0051653	spindle localization	3.07	1.82e-03	3.09e-02	8/16	ASPM; SAPCD2; CENPA; ESPL1; GPSM2; LLGL2; NDC80; NUSAP1
GO:0044839	cell cycle G2/M phase transition	3.03	1.99e-12	1.89e-10	41/83	ATAD5; AURKA; AURKB; BLM; BRCA1; BTRC; TICRR; CCNA2; CCNB1; CCNB2; CCNB3; CCND1; CDC25A; CDC25B; CDC25C; CDC6; CDC7; CDK1; CENPF; CHEK1; CIT; CLSPN; DTL; FBXO5; FOXM1; GTSE1; HMMR; KIF14; MELK; NEK10; NEK2; ORC1; PCM1; PKMYT1; PLK1; PLK4; RAD21; RECQL4; SKP2; STOX1; TPX2
GO:0001578	microtubule bundle formation	2.96	1.27e-08	4.91e-07	28/58	ARMC4; CFAP43; DRC1; CFAP206; CFAP157; CCDC103; CCDC114; CCDC39; CCDC65; DNAH7; DNAI2; DNAJB13; DNALI1; HYDIN; KIF20A; LRGUK; LRRC49; DNAAF1; LRRC6; NCKAP5; NEURL1; PLK1; PRC1; PSRC1; RSPH1; RSPH4A; TEKT2; ZMYND10
GO:0000726	non-recombinational repair	2.89	2.95e-03	4.45e-02	8/17	BARD1; BLM; BRCA1; AUNIP; DEK; H2AFX; POLQ; PRKDC
GO:0048285	organelle fission	2.84	0.00e+00	0.00e+00	100/216	ANLN; ASPM; AURKA; AURKB; BLM; BMP7; BNIP3; BRCA2; BRIP1; BUB1B; BUB1; KNSTRN; M1AP; MCMDC2; C9orf84; CCNA2; CCNB1; CCNB2; CCNB3; CCND1; CCNE1; CCNE2; CCNF; CCNI2; CDC20; CDC25B; CDC25C; CDC6; CDCA5; CDCA8; CDT1; CENPE; CENPF; CEP55; CHEK1; CKS2; DDHD2; DLGAP5; DMRTC2; DSCC1; EME1; EPGN; ESPL1; MTFR2; FANCA; FBXO5; GDAP1; HASPIN; IL1A; WASHC5; KIF11; KIF14; KIF18A; KIF18B; KIF23; KIF2C; KIF4A; KIFC1; KNTC1; MAD2L1; MKI67; MND1; MTBP; MTFR1; MYBL1; MYBL2; NCAPD2; NCAPG; NCAPH; NDC80; NEK2; NUF2; NUSAP1; PKMYT1; PLK1; PPARGC1A; PRC1; PSRC1; PTTG1; RACGAP1; RAD21; RAD51; RAD54B; RRS1; SGO1; SGO2; SMC4; SPAG5; SYCP1; SYCP3; TACC3; NDC1; TOP2A; TPX2; TRIP13; TTK; UBE2C; UBE2S; WNT4; ZWINT
GO:0000910	cytokinesis	2.81	9.50e-08	3.36e-06	27/59	ANLN; AURKA; AURKB; BRCA2; CDC25B; CDC6; CDT1; CENPA; CEP55; CIT; CKAP2; E2F7; E2F8; ECT2; ESPL1; WASHC5; KIF14; KIF20A; KIF23; KIF4A; NUSAP1; PLK1; PRC1; PRKCE; RACGAP1; SEPT3; STMN1
GO:0044772	mitotic cell cycle phase transition	2.78	0.00e+00	0.00e+00	87/192	ANLN; ATAD5; AURKA; AURKB; BCL2; BLM; BRCA1; BTRC; BUB1B; BUB1; TICRR; CCNA2; CCNB1; CCNB2; CCNB3; CCND1; CCNE1; CCNE2; CDC20; CDC25A; CDC25B; CDC25C; CDC45; CDC6; CDC7; CDCA5; CDK1; CDKN2C; CDKN2D; CDKN3; CDT1; CENPE; CENPF; CIT; CKS1B; CKS2; CLSPN; DBF4; DLGAP5; DTL; E2F1; E2F7; E2F8; ESPL1; EZH2; FBXO5; FOXM1; GMNN; GTSE1; HMMR; IQGAP3; KIF14; KNTC1; MAD2L1; MCM10; MCM2; MCM4; MCM5; MCM6; MCM7; MELK; MTBP; NDC80; NEK11; NEK2; ORC1; PCM1; PKMYT1; PLK1; PLK4; POLE2; PRKDC; RAD21; RBL1; RECQL4; RHOU; RRM2; SKP2; STOX1; TACC3; TPX2; TRIP13; TTK; TYMS; UBE2C; UBE2S; USP26
GO:1901987	regulation of cell cycle phase transition	2.64	6.33e-15	8.59e-13	64/149	ANLN; ATAD5; AURKA; AURKB; BCL2; BLM; BRCA1; BTRC; BUB1B; BUB1; C10orf99; TICRR; CCNB1; CCNB3; CCND1; CCNE1; CDC20; CDC25A; CDC25B; CDC25C; CDC45; CDC6; CDC7; CDCA5; CDK1; CDKN2D; CDT1; CENPE; CENPF; CHEK1; CLSPN; DLGAP5; DTL; E2F1; E2F7; E2F8; ESPL1; EZH2; FAM83D; FBXO5; GTSE1; HMMR; KIF14; KNTC1; MAD2L1; MTBP; NDC80; NEK10; NEK11; NEK2; ORC1; PCM1; PLK1; PLK4; PRKDC; RAD21; RBL1; RECQL4; STOX1; SUSD2; TPX2; TRIP13; TTK; UBE2C
GO:0010948	negative regulation of cell cycle process	2.60	4.94e-11	2.68e-09	47/111	AURKA; AURKB; BCL2; BLM; BMP7; BRCA1; BUB1B; BUB1; C10orf99; TICRR; CCNB1; CCND1; CCNF; CDC20; CDC25C; CDC6; CDC7; CDK1; CDKN2D; CDT1; CENPF; CHEK1; CLSPN; DTL; E2F1; E2F7; E2F8; ESPL1; EZH2; FBXO5; GPER1; GTSE1; MAD2L1; MTBP; NDC80; NEK2; ORC1; PLK1; PRKDC; PTTG1; RAD21; RAD51; RBL1; RRM2; SUSD2; TRIP13; TTK
GO:0044843	cell cycle G1/S phase transition	2.59	9.11e-11	4.64e-09	46/109	AURKA; BCL2; C10orf99; CCNA2; CCNB1; CCND1; CCNE1; CCNE2; CDC25A; CDC25C; CDC45; CDC6; CDC7; CDK1; CDKN2C; CDKN2D; CDKN3; CDT1; DBF4; E2F1; E2F7; E2F8; EZH2; FAM83D; FBXO5; GMNN; GTSE1; IQGAP3; KIF14; MCM10; MCM2; MCM4; MCM5; MCM6; MCM7; MTBP; ORC1; POLE2; PRKDC; RBL1; RHOU; RRM2; SKP2; SUSD2; TYMS; USP26
GO:0007018	microtubule-based movement	2.59	2.09e-12	1.89e-10	54/128	ARMC4; DRC1; MAATS1; CFAP206; CABYR; CCDC103; CCDC114; CFAP53; CCDC39; CCDC65; CENPE; CNIH2; DLGAP5; DNAH11; DNAH12; DNAH6; DNAH7; DNAH9; DNAI2; HIF1A; HYDIN; KIF11; KIF14; KIF15; KIF18A; KIF18B; KIF20A; KIF21A; KIF21B; KIF23; KIF24; KIF2C; KIF4A; KIF6; KIFC1; KIFC2; DNAAF1; LRRC6; MAK; NME5; CFAP221; PCM1; RACGAP1; RASGRP1; ROPN1L; RSPH4A; SPA17; TEKT1; TEKT2; TEKT3; WDR34; WDR63; WDR66; WDR78
GO:0031023	microtubule organizing center organization	2.57	5.85e-05	1.44e-03	18/43	AURKA; BRCA1; BRCA2; CALML5; CCNF; CDK1; CHEK1; PCLAF; KIF11; NEK2; PARD6B; PCM1; PLK1; PLK4; POC1A; SGO1; STIL; WDR62
GO:1904029	regulation of cyclin-dependent protein kinase activity	2.57	5.74e-06	1.61e-04	23/55	BLM; CCNA2; CCNB1; CCNB2; CCNB3; CCND1; CCNE1; CCNE2; CCNF; CCNI2; CDC25A; CDC25C; CDC6; CDKN2C; CDKN2D; CDKN3; CKS1B; CKS2; HHEX; PKMYT1; PLK1; PSRC1; STOX1
GO:0051321	meiotic cell cycle	2.55	4.40e-12	3.26e-10	54/130	ASPM; AURKA; BLM; BRCA2; BRIP1; BUB1B; BUB1; M1AP; MCMDC2; C9orf84; CCNB3; CCNE1; CCNE2; CDC20; CDC25A; CDC25B; CDC25C; CKS2; DMRTC2; EME1; ESPL1; EXO1; FAM9A; FANCA; FBXO5; H2AFX; WASHC5; KIF18A; MND1; MYBL1; NCAPD2; NCAPH; NEK2; NUF2; PKMYT1; PLK1; PTTG1; RAD21; RAD51; RAD54B; RAD54L; RSPH1; SGO1; SGO2; SMC1B; SMC4; SYCP1; SYCP3; TDRD1; NDC1; TOP2A; TRIP13; TTK; WNT4
GO:0006338	chromatin remodeling	2.46	5.03e-05	1.28e-03	20/50	KNL1; CENPA; CENPI; CENPK; CENPM; CENPN; CENPW; CHD5; CHEK1; ESR1; HELLS; HJURP; HMGB2; HMGB3; CENPU; OIP5; PABPC1L; PADI2; PAX7; SYCP3
GO:0018149	peptide cross-linking	2.42	5.16e-04	1.05e-02	15/38	CSTA; IVL; KRT2; PI3; SPRR1A; SPRR1B; SPRR2A; SPRR2B; SPRR2D; SPRR2E; SPRR2F; SPRR3; SPRR4; TGM2; TGM4
GO:0033044	regulation of chromosome organization	2.42	1.08e-08	4.41e-07	41/104	ATAD2; AURKB; BRCA1; BUB1B; BUB1; RMI2; CAMK2D; CCNB1; CDC20; CDC45; CDC6; CDCA5; CDT1; CENPE; CENPF; CHEK1; DDX11; DLGAP5; DMRTC2; DNMT3B; ESPL1; FBXO5; FEN1; HMBOX1; MAD2L1; MCM2; MKI67; NDC80; NEK2; PADI2; PAX7; PHF19; PIF1; PLK1; PPARGC1A; PTTG1; RAD21; TACC3; TOP2A; TRIP13; TTK
GO:0006997	nucleus organization	2.42	1.24e-03	2.17e-02	13/33	CCNB1; CCNB2; CDK1; CEP55; CHD5; DMRTC2; GPER1; HMGB2; PLK1; REEP4; SYCP1; SYCP3; NDC1
GO:0006310	DNA recombination	2.39	3.52e-08	1.30e-06	39/100	ATAD5; BLM; BRCA1; BRCA2; BRIP1; PARPBP; RMI2; AUNIP; MCMDC2; C9orf84; CDC45; CDC7; CHEK1; EME1; EXO1; FANCB; FEN1; GINS2; GINS4; H2AFX; HMGB2; HMGB3; KPNA2; MND1; TONSL; PIF1; POLQ; PRKDC; RAD21; RAD51AP1; RAD51; RAD54B; RAD54L; RECQL4; SYCP1; TFRC; ALYREF; TOP2A; TRIP13
GO:0045930	negative regulation of mitotic cell cycle	2.39	4.95e-09	2.24e-07	44/113	AURKA; AURKB; BCL2; BLM; BMP7; BRCA1; BUB1B; BUB1; TICRR; CCNB1; CCND1; CDC20; CDC25C; CDC6; CDK1; CDT1; CENPF; CHEK1; CLSPN; E2F1; E2F7; E2F8; EGFR; EME1; EZH2; BRINP3; FBXO5; GTSE1; KNTC1; MAD2L1; MTBP; NDC80; NEK11; ORC1; PLK1; PRKDC; PTTG1; RAD21; RBL1; SCRIB; TOP2A; TRIP13; TTK; ZWINT
GO:0042770	signal transduction in response to DNA damage	2.24	3.15e-04	6.76e-03	19/52	ATAD5; AURKA; BRCA1; BRCA2; CCNB1; CDC25C; CDK1; CHEK1; DTL; E2F1; E2F7; E2F8; FOXM1; GTSE1; NDRG1; PLK1; PMAIP1; PRKDC; SNAI1
GO:0045787	positive regulation of cell cycle	2.15	1.12e-10	5.37e-09	67/191	ASCL1; ATAD5; AURKA; AURKB; BRCA1; BRCA2; CCNA2; CCNB1; CCNB2; CCNB3; CCND1; CCNE1; CCNE2; CCNF; CCNI2; CDC25A; CDC25B; CDC25C; CDC45; CDC6; CDC7; CDCA5; CDK1; CDT1; CHEK1; CIT; CKS1B; CKS2; DDX11; DLGAP5; DTL; E2F1; E2F7; E2F8; ECT2; EPGN; ESPL1; EZH2; FAM83D; FBXO5; FEN1; FGFR2; FOSL1; GATA6; GPER1; GPSM2; GTSE1; IL1A; KIF14; KIF23; MAD2L1; MTBP; MYOG; NDC80; NUSAP1; PLK4; POC1A; PRKCE; PSRC1; RACGAP1; RAD21; RECQL4; SLC6A4; SPAG5; STOX1; UBE2C; WNT4
GO:0071897	DNA biosynthetic process	2.15	3.09e-04	6.76e-03	21/60	AURKB; BLM; CDKN2D; CENPF; CHTF18; DSCC1; DTL; FGFR4; HMBOX1; PCLAF; LIN9; NEK2; PARP3; PIF1; POLD1; POLE2; POLQ; RFC4; SYCP1; TK1; TYMS
GO:0018210	peptidyl-threonine modification	2.05	2.79e-03	4.29e-02	16/48	AZU1; BCL2; BMP7; CAMK2D; CDC7; CDK1; CHEK1; DDIT4; DMTN; GALNT3; HASPIN; PLK1; RIPK2; STOX1; TGFBR1; TTK
GO:0044782	cilium organization	2.03	1.24e-07	4.02e-06	52/157	ABLIM1; ARMC4; B9D1; CFAP43; CFAP126; DRC1; CATIP; C5orf30; CFAP206; CFAP157; CCDC103; CCDC114; CFAP53; CCDC13; CCDC39; CCDC65; CDK1; DCDC2; DNAH7; DNAI2; DNAJB13; DNALI1; FOXJ1; FUZ; HYDIN; IQUB; CEP126; KIF24; LRGUK; LRRC49; DNAAF1; LRRC6; MAK; NEK2; NEURL1; NME5; NOTO; NPHP1; CFAP221; PCM1; PLK1; PLK4; POC1A; RSPH1; RSPH4A; SEPT3; TEKT1; TEKT2; TEKT3; UBXN10; WDR34; ZMYND10
GO:0072331	signal transduction by p53 class mediator	2.02	1.12e-04	2.67e-03	28/85	ATAD5; AURKA; AURKB; BCL2; BOP1; BRCA1; BRCA2; CCNB1; CDC25C; CDK1; CHD5; CHEK1; DDIT4; E2F1; E2F2; E2F7; E2F8; ELL3; FOXM1; GTSE1; NDRG1; NUPR1; PERP; PMAIP1; PYCARD; RRS1; SNAI1; TPX2
GO:0071824	protein-DNA complex subunit organization	2.02	1.49e-04	3.36e-03	27/82	ASF1B; MCMDC2; KNL1; CDC45; CDT1; CENPA; CENPE; CENPF; CENPI; CENPK; CENPM; CENPN; CENPW; CHAF1B; CHD5; ESR1; GMNN; H2AFX; HELLS; HJURP; HMGB2; MCM2; CENPU; NAP1L5; OIP5; RAD51; SYCP3
GO:0051052	regulation of DNA metabolic process	2.00	6.08e-07	1.90e-05	48/147	ANXA3; ATAD5; AURKB; BLM; BRCA1; BRCA2; PARPBP; TICRR; RMI2; AUNIP; CCNA2; CDC6; CDC7; CDK1; CDT1; CHEK1; CHTF18; DBF4; DDX11; DEK; DNA2; DSCC1; E2F7; E2F8; EGFR; ESCO2; FANCB; FBXO5; FGFR4; FOXM1; GMNN; GPER1; H2AFX; HMBOX1; KPNA2; NEK2; PARP3; PIF1; POLQ; PPARGC1A; RAD51AP1; RAD51; RECQL4; RFC4; STOX1; TFRC; ALYREF; ZNF93

CDH1_LOF : 31 significant GO terms

GeneSet	description	enrichRatio	pValue	FDR	GeneRatio	geneSymbols
GO:0051383	kinetochore organization	4.95	3.88e-07	1.31e-05	10/11	CDT1; CENPA; CENPE; CENPF; CENPK; CENPN; CENPW; NDC80; NUF2; SMC4
GO:0061641	CENP-A containing chromatin organization	4.19	7.02e-06	1.63e-04	10/13	KNL1; CENPA; CENPI; CENPK; CENPM; CENPN; CENPW; HJURP; CENPU; OIP5
GO:0050000	chromosome localization	3.83	4.53e-09	2.17e-07	19/27	ANKRD53; CCNB1; CDCA5; CDCA8; CDT1; CENPE; CENPF; CEP55; DLGAP5; FAM83D; GEM; KIF14; KIF18A; KIF2C; KIFC1; NDC80; NUF2; PSRC1; SPAG5
GO:0031579	membrane raft organization	3.63	3.09e-04	5.48e-03	8/12	CAV1; CAV2; CD2; DOCK2; GSN; MAL; PTPRC; RFTN1
GO:0034502	protein localization to chromosome	3.47	3.38e-06	8.59e-05	14/22	AURKB; BUB1B; KNL1; CDCA5; CDK1; CDT1; CENPA; ESCO2; EZH2; HASPIN; MTBP; NDC80; PLK1; TTK
GO:1902850	microtubule cytoskeleton organization involved in mitosis	3.39	1.60e-12	2.61e-10	33/53	ANKRD53; AURKA; AURKB; SAPCD2; CCNB1; CDC20; CENPA; CENPE; ESPL1; GNAI1; GPSM2; KIF11; KIF23; KIF4A; KIFC1; MYBL2; NDC80; NEK2; NUF2; NUSAP1; PLK1; POC1A; PRC1; PSRC1; RACGAP1; SPRY1; SPRY2; STIL; STMN1; TACC3; TPX2; TTK; WDR62
GO:0007059	chromosome segregation	3.36	0.00e+00	0.00e+00	77/125	ANKRD53; AURKB; BIRC5; BLM; BRCA1; BRIP1; BUB1B; BUB1; KNSTRN; RMI2; C9orf84; KNL1; CCNB1; CCNE1; CCNE2; CDC20; CDC6; CDCA5; CDCA8; CDT1; CENPE; CENPF; CENPN; CENPW; CEP55; DDX11; DLGAP5; DSCC1; DUSP1; ECT2; EME1; ESCO2; ESPL1; FAM83D; FBXO5; FEN1; GEM; HASPIN; HJURP; KIF14; KIF18A; KIF18B; KIF23; KIF2C; KIF4A; KIFC1; MAD2L1; MKI67; NCAPD2; NCAPG; NCAPH; NDC80; NEK2; NUF2; NUSAP1; OIP5; PLK1; PRC1; PSRC1; PTTG1; RACGAP1; RAD51C; SGO1; SGO2; SKA1; SKA2; SKA3; SMC4; SPAG5; SPATA22; SYCE2; TACC3; TOP2A; TRIP13; TTK; USP44; ZWINT
GO:0006260	DNA replication	3.18	0.00e+00	0.00e+00	56/96	ATAD5; BLM; BRCA1; BRIP1; TICRR; RMI2; CCNA2; CCNE1; CCNE2; CDC45; CDC6; CDC7; CDK1; CDT1; CHAF1B; CHEK1; CLSPN; DBF4; DDX11; DNA2; DSCC1; DTL; E2F7; E2F8; EME1; ESCO2; EXO1; FBXO5; FEN1; GINS1; GINS2; GINS4; GLI1; GMNN; JUN; PCLAF; MCM10; MCM2; MCM4; MCM5; MCM6; MCM7; NFIB; TONSL; NPM2; ORC1; PIF1; POLE2; POLQ; RAD51; RECQL4; RFC4; RNASEH2A; RRM2; ALYREF; WDHD1
GO:0036297	interstrand cross-link repair	3.18	2.31e-03	2.58e-02	7/12	EME1; FANCA; FANCB; FANCI; RAD51AP1; RAD51; UBE2T
GO:0051653	spindle localization	3.06	7.60e-04	1.08e-02	9/16	ASPM; SAPCD2; CENPA; ESPL1; GPSM2; NDC80; NUSAP1; SPRY1; SPRY2
GO:0045023	G0 to G1 transition	2.93	4.22e-03	4.34e-02	7/13	BRCA1; CDC7; CHEK1; E2F1; EZH2; RAD51; RRM2
GO:0000075	cell cycle checkpoint	2.84	6.85e-11	7.97e-09	38/73	AURKA; AURKB; BLM; BRCA1; BRIP1; BUB1B; BUB1; TICRR; CCNB1; CDC20; CDC25C; CDC45; CDC6; CDK1; CDT1; CENPF; CHEK1; CLSPN; DNA2; DTL; DUSP1; E2F1; E2F7; E2F8; EME1; GTSE1; H2AFX; KNTC1; MAD2L1; NDC80; ORC1; PLK1; TOP2A; TRIP13; TTK; USP44; WDR76; ZWINT
GO:0007051	spindle organization	2.81	1.00e-09	8.14e-08	34/66	ANKRD53; ASPM; AURKA; AURKB; KNSTRN; AUNIP; CCDC69; CCNB1; CDC20; CENPE; ESPL1; FBXO5; GNAI1; GPSM2; KIF11; KIF23; KIF4A; KIFC1; MYBL2; NDC80; NEK2; NUF2; PLK1; POC1A; PRC1; PSRC1; RACGAP1; SPAG5; STIL; STMN1; TACC3; TPX2; TTK; WDR62
GO:0000910	cytokinesis	2.77	1.45e-08	6.19e-07	30/59	ANKRD53; ANLN; AURKA; AURKB; CDC25B; CDC6; CDT1; CENPA; CEP55; CIT; CKAP2; CXCR5; E2F7; E2F8; ECT2; ESPL1; KIF14; KIF20A; KIF23; KIF4A; KLHL13; NUSAP1; PLK1; PRC1; RACGAP1; ROPN1B; SEPT3; SEPT4; STMN1; SVIL
GO:0044772	mitotic cell cycle phase transition	2.55	0.00e+00	0.00e+00	90/192	ABCB1; ADAMTS1; ANLN; ATAD5; AURKA; AURKB; BLM; BRCA1; BUB1B; BUB1; TICRR; CCNA2; CCNB1; CCNB2; CCNE1; CCNE2; CDC20; CDC25A; CDC25B; CDC25C; CDC45; CDC6; CDC7; CDCA5; CDK1; CDKN2D; CDKN3; CDT1; CENPE; CENPF; CIT; CKS1B; CKS2; CLSPN; DBF4; DLGAP5; DTL; DUSP1; E2F1; E2F7; E2F8; ESPL1; EZH2; FAM107A; FBXO5; FHL1; FOXM1; GFI1; GMNN; GTSE1; HMMR; HYAL1; ID4; IQGAP3; KCNA5; KIF14; KLF4; KNTC1; LZTS1; MAD2L1; MCM10; MCM2; MCM4; MCM5; MCM6; MCM7; MELK; MTBP; MYC; NDC80; NEK2; NES; NPM2; ORC1; PKMYT1; PLK1; PLK4; POLE2; RAD51C; RECQL4; RRM2; TACC3; TPX2; TRIP13; TTK; TYMS; UBE2C; UBE2S; USP44; ZFP36L2
GO:0032200	telomere organization	2.55	2.04e-04	3.78e-03	15/32	AURKB; BLM; CCNE1; CCNE2; DNA2; EXO1; FEN1; MYC; NEK2; PIF1; PRKCQ; RAD51C; RAD51; RECQL4; RFC4
GO:0071897	DNA biosynthetic process	2.54	4.45e-07	1.45e-05	28/60	ADIPOQ; AURKB; BLM; CDKN2D; CENPF; DSCC1; DTL; DUSP1; FGF2; HGF; PCLAF; KLF4; LIN9; MYC; NEK2; PAK3; PDGFA; PDGFRB; PIF1; POLE2; POLQ; PPARG; PRKCQ; RFC4; RGN; SPATA22; TK1; TYMS
GO:0006302	double-strand break repair	2.46	1.85e-07	6.54e-06	32/71	BLM; BRCA1; BRIP1; PARPBP; RMI2; AUNIP; CDC45; CDC7; CDCA5; CHEK1; DDX11; DEK; DNA2; EME1; ESCO2; EXO1; FANCB; FEN1; FOXM1; GINS2; GINS4; H2AFX; TONSL; POLQ; RAD51AP1; RAD51C; RAD51; RAD54B; RAD54L; RECQL4; TRIP13; WAS
GO:0044839	cell cycle G2/M phase transition	2.43	2.93e-08	1.08e-06	37/83	ABCB1; ATAD5; AURKA; AURKB; BLM; BRCA1; TICRR; CCNA2; CCNB1; CCNB2; CDC25A; CDC25B; CDC25C; CDC6; CDC7; CDK1; CENPF; CHEK1; CIT; CLSPN; DTL; FBXO5; FHL1; FOXM1; GTSE1; HMMR; KIF14; MELK; NEK2; NES; ORC1; PKMYT1; PLK1; PLK4; RAD51C; RECQL4; TPX2
GO:0071103	DNA conformation change	2.39	4.02e-09	2.05e-07	43/98	ASF1B; BLM; BRIP1; KNL1; CCNB1; CDC45; CDCA5; CDK1; CENPA; CENPI; CENPK; CENPM; CENPN; CENPW; CHAF1B; DDX11; DNA2; GINS1; GINS2; GINS4; H2AFX; HELLS; HJURP; HMGB2; MCM2; MCM4; MCM6; MCM7; CENPU; NAP1L2; NCAPD2; NCAPG2; NCAPG; NCAPH; NUSAP1; OIP5; PIF1; RAD51; RAD54B; RAD54L; RECQL4; SMC4; TOP2A
GO:0048285	organelle fission	2.37	0.00e+00	0.00e+00	94/216	ANKRD53; ANLN; ASPM; AURKA; AURKB; BLM; BRIP1; BUB1B; BUB1; KNSTRN; C9orf84; CAV2; CCDC8; CCNA2; CCNB1; CCNB2; CCNE1; CCNE2; CCNF; CDC20; CDC25B; CDC25C; CDC6; CDCA5; CDCA8; CDT1; CENPE; CENPF; CEP55; CHEK1; CKS2; CNTD2; DLGAP5; DSCC1; DUSP1; EDN1; EDN3; EME1; ESPL1; MTFR2; FANCA; FBXO5; HASPIN; IGF1; IL1A; KIF11; KIF14; KIF18A; KIF18B; KIF23; KIF2C; KIF4A; KIFC1; KNTC1; MAD2L1; MKI67; MND1; MTBP; MYBL1; MYBL2; NCAPD2; NCAPG; NCAPH; NDC80; NEK2; NPM2; NUF2; NUSAP1; PDE3A; PDGFRB; PKMYT1; PLK1; PRC1; PSRC1; PTTG1; RACGAP1; RAD51C; RAD51; RAD54B; SGO1; SGO2; SMC4; SPAG5; SPATA22; SYCE2; TACC3; TOP2A; TPX2; TRIP13; TTK; UBE2C; UBE2S; USP44; ZWINT
GO:0010948	negative regulation of cell cycle process	2.36	9.15e-10	8.14e-08	48/111	AURKA; AURKB; BLM; BRCA1; BUB1B; BUB1; C10orf99; TICRR; CCNB1; CCNF; CDC20; CDC25C; CDC6; CDC7; CDK1; CDKN2D; CDT1; CENPF; CHEK1; CLSPN; DTL; DUSP1; E2F1; E2F7; E2F8; ESPL1; EVI2B; EZH2; FAM107A; FBXO5; FHL1; GTSE1; KLF4; MAD2L1; MLXIPL; MTBP; NDC80; NEK2; ORC1; PLK1; PTTG1; RAD51; RRM2; TRIM37; TRIP13; TTK; USP44; ZFP36L2
GO:0044843	cell cycle G1/S phase transition	2.35	1.54e-09	9.64e-08	47/109	ADAMTS1; AURKA; C10orf99; CCNA2; CCNB1; CCNE1; CCNE2; CDC25A; CDC25C; CDC45; CDC6; CDC7; CDK1; CDKN2D; CDKN3; CDT1; DBF4; E2F1; E2F7; E2F8; EZH2; FAM107A; FAM83D; FBXO5; FHL1; GFI1; GLI1; GMNN; GTSE1; HYAL1; ID4; IQGAP3; KCNA5; KIF14; KLF4; MCM10; MCM2; MCM4; MCM5; MCM6; MCM7; MTBP; MYC; ORC1; POLE2; RRM2; TYMS
GO:1901987	regulation of cell cycle phase transition	2.34	2.01e-12	2.72e-10	64/149	ADAMTS1; ANLN; ATAD5; AURKA; AURKB; BLM; BRCA1; BUB1B; BUB1; C10orf99; TICRR; CCNB1; CCNE1; CDC20; CDC25A; CDC25B; CDC25C; CDC45; CDC6; CDC7; CDCA5; CDK1; CDKN2D; CDT1; CENPE; CENPF; CHEK1; CLSPN; DLGAP5; DTL; DUSP1; E2F1; E2F7; E2F8; ESPL1; EZH2; FAM107A; FAM83D; FBXO5; FHL1; GLI1; GTSE1; HMMR; HYAL1; KCNA5; KIF14; KLF4; KNTC1; MAD2L1; MTBP; NDC80; NEK2; NPM2; ORC1; PLK1; PLK4; RAD51C; RECQL4; TPX2; TRIP13; TTK; UBE2C; USP44; ZFP36L2
GO:0033044	regulation of chromosome organization	2.30	1.04e-08	4.72e-07	44/104	ATAD2; AURKB; BRCA1; BUB1B; BUB1; RMI2; CCNB1; CDC20; CDC45; CDC6; CDCA5; CDT1; CENPE; CENPF; CHEK1; DDX11; DLGAP5; DNMT3B; DUSP1; ESPL1; FBXO5; FEN1; GFI1; MAD2L1; MCM2; MKI67; MYC; MYOCD; NAP1L2; NDC80; NEK2; PAX5; PHF19; PIF1; PLK1; PRKCQ; PTTG1; SNCA; TACC3; TAL1; TOP2A; TRIP13; TTK; USP44
GO:0018149	peptide cross-linking	2.29	5.72e-04	8.78e-03	16/38	CSTA; EGFLAM; EPB42; IVL; SPOCK2; SPOCK3; SPRR1A; SPRR1B; SPRR2A; SPRR2B; SPRR2D; SPRR2E; SPRR2F; SPRR3; SPRR4; TGM5
GO:0006310	DNA recombination	2.29	2.91e-08	1.08e-06	42/100	ATAD5; BCL11B; BLM; BRCA1; BRIP1; PARPBP; RMI2; AUNIP; C9orf84; CCR6; CD40LG; CD40; CDC45; CDC7; CHEK1; EME1; EXO1; FANCB; FEN1; GINS2; GINS4; H2AFX; HMGB2; IL7R; KPNA2; MND1; TONSL; PIF1; POLQ; PTPRC; RAD51AP1; RAD51C; RAD51; RAD54B; RAD54L; RECQL4; TBX21; TCF7; ALYREF; TOP2A; TRIP13; WAS
GO:0051052	regulation of DNA metabolic process	2.15	1.24e-09	9.15e-08	58/147	ADIPOQ; ANXA3; ATAD5; AURKB; BLM; BRCA1; PARPBP; TICRR; RMI2; AUNIP; CCNA2; CD40; CDC6; CDC7; CDK1; CDT1; CHEK1; CIDEA; DBF4; DDX11; DEK; DNA2; DSCC1; DUSP1; E2F7; E2F8; ESCO2; FANCB; FBXO5; FGF2; FOXM1; GLI1; GMNN; H2AFX; HGF; IL7R; JUN; KLF4; KPNA2; MYC; NEK2; NPM2; PAK3; PDGFA; PDGFRB; PIF1; POLQ; PPARG; PRKCQ; PTPRC; RAD51AP1; RAD51; RECQL4; RFC4; RGN; TBX21; ALYREF; WAS
GO:0051302	regulation of cell division	2.10	2.43e-06	6.83e-05	37/96	ANKRD53; ASPM; AURKA; AURKB; BLM; C10orf99; CDC25B; CDC6; CIT; CXCR5; E2F7; E2F8; ECT2; EVI2B; FGF1; FGF2; FGF7; VEGFD; IL1A; KIF14; KIF18B; KIF20A; KIF23; KLHL13; MYC; NAP1L2; PDGFA; PDGFD; PLK1; PRC1; PROK1; PTN; RACGAP1; SOX17; SVIL; TAL1; THBS4
GO:1904029	regulation of cyclin-dependent protein kinase activity	2.08	4.21e-04	6.98e-03	21/55	BLM; CCNA2; CCNB1; CCNB2; CCNE1; CCNE2; CCNF; CDC25A; CDC25C; CDC6; CDKN2D; CDKN3; CEBPA; CKS1B; CKS2; CNTD2; DIRAS3; MYOCD; PKMYT1; PLK1; PSRC1
GO:0031023	microtubule organizing center organization	2.03	2.72e-03	2.95e-02	16/43	AURKA; BRCA1; CCNF; CDK1; CHEK1; PCLAF; KIF11; NEK2; PKHD1; PLK1; PLK4; POC1A; SGO1; STIL; TRIM37; WDR62

GATA3_LOF : 24 significant GO terms

GeneSet	description	enrichRatio	pValue	FDR	GeneRatio	geneSymbols
GO:0140029	exocytic process	6.37	2.06e-07	2.79e-05	12/47	CPLX1; CPLX2; KCNB1; NAPB; PPFIA3; RAB3A; RAB3C; SNAP25; STX1A; STXBP1; SYT7; UNC13A
GO:0048284	organelle fusion	5.67	6.83e-06	5.56e-04	10/44	CPLX1; CPLX2; GDAP1; RAB39A; RAB3A; SNAP25; STX1A; STXBP1; SYT4; SYT7
GO:0017156	calcium ion regulated exocytosis	5.08	4.77e-10	1.94e-07	21/103	CACNB2; CDK5R2; CHRNB2; CPLX1; CPLX2; KCNB1; NAPB; PPFIA3; RAB3A; RIMS2; SCAMP5; SNAP25; STX1A; STXBP1; SYN1; SYP; SYT13; SYT4; SYT5; SYT7; UNC13A
GO:0035418	protein localization to synapse	4.99	1.53e-04	7.31e-03	8/40	BSN; CPLX1; GRIN2C; IQSEC2; KIF5A; ARHGAP44; SNAP25; WNT5A
GO:0099504	synaptic vesicle cycle	4.86	6.91e-11	5.63e-08	24/123	BRSK1; BRSK2; BSN; CACNB2; CDK5R1; CHRNB2; CPLX1; CPLX2; DNAJC6; NAPB; PPFIA3; RAB3A; RIMS2; SNAP25; SNCB; STX1A; STXBP1; SYN1; SYP; SYT13; SYT4; SYT5; SYT7; UNC13A
GO:0099003	vesicle-mediated transport in synapse	4.69	9.34e-10	2.53e-07	22/117	AP3B2; CACNB2; CHRNB2; CPLX1; CPLX2; DNAJC6; KIF5A; NAPB; PPFIA3; RAB3A; RIMS2; SNAP25; SNCB; STX1A; STXBP1; SYN1; SYP; SYT13; SYT4; SYT5; SYT7; UNC13A
GO:0022406	membrane docking	4.32	1.91e-04	8.64e-03	9/52	CPLX2; KCNB1; PPFIA3; RAB3A; RAB3C; SNAP25; STX1A; STXBP1; UNC13A
GO:0051648	vesicle localization	3.93	1.38e-08	2.25e-06	23/146	AP3B2; BRSK1; BRSK2; CACNB2; CHRNB2; CPLX1; CPLX2; GRIA1; KIF5A; NAPB; PPFIA3; RAB3A; RIMS2; SNAP25; STX1A; STXBP1; SYN1; SYP; SYT13; SYT4; SYT5; SYT7; UNC13A
GO:0015844	monoamine transport	3.72	3.01e-04	1.17e-02	10/67	CARTPT; CHGA; CHRNB2; HRH3; KCNB1; STX1A; SYT13; SYT4; SYT5; SYT7
GO:0061025	membrane fusion	3.62	7.42e-04	2.74e-02	9/62	CPLX1; CPLX2; RAB39A; RAB3A; SNAP25; STX1A; STXBP1; SYT4; SYT7
GO:0015837	amine transport	3.47	2.84e-04	1.16e-02	11/79	CARTPT; CHGA; CHRNB2; HRH3; KCNB1; STX1A; STXBP1; SYT13; SYT4; SYT5; SYT7
GO:0099565	chemical synaptic transmission, postsynaptic	3.47	2.84e-04	1.16e-02	11/79	CELF4; CHRNB2; GRIK2; GRIN2C; IGSF9B; MAPK8IP2; MPP2; P2RX6; RIMS2; SEZ6; STX1A
GO:0072089	stem cell proliferation	3.28	8.43e-04	2.99e-02	10/76	ACE; ACSL6; ASCL1; EML1; FGFR1; NEUROD4; SMARCD3; WNT5A; YAP1; ZFP36L1
GO:0006836	neurotransmitter transport	3.18	4.08e-07	4.75e-05	24/188	BRSK1; CACNB2; CHRNB2; CPLX1; CPLX2; GRM4; HRH3; NAPB; PPFIA3; PTPRN2; RAB3A; RIMS2; SLC1A2; SLC6A17; SNAP25; STX1A; STXBP1; SYN1; SYP; SYT13; SYT4; SYT5; SYT7; UNC13A
GO:0099177	regulation of trans-synaptic signaling	3.01	3.43e-09	6.97e-07	35/290	ACHE; BRSK1; CACNB2; CAMK2B; CELF4; CHRNB2; CPLX1; CPLX2; DGKE; GRIA1; GRIK2; GRIN2C; GRM4; IGSF9B; IQSEC2; JPH3; KCNB1; KIT; MAPK8IP2; MPP2; NAPB; NPTXR; PPFIA3; RAB3A; RIMS2; SCGN; SLC8A2; SNAP25; STX1A; STXBP1; SYN1; SYP; SYT4; SYT7; UNC13A
GO:0032386	regulation of intracellular transport	2.77	1.27e-05	9.39e-04	22/198	ABCA2; ANK3; BRSK2; CACNB2; CDK5R1; CHRNB2; CPLX1; CPLX2; KCNB1; NAPB; PIK3R1; RAB3A; REEP2; ARHGAP44; RIMS2; STX1A; STXBP1; SYN1; SYP; SYT4; SYT7; TCF7L2
GO:1990778	protein localization to cell periphery	2.77	7.91e-05	4.29e-03	18/162	ANK1; ANK3; CACNB2; CPLX1; GRIN2C; IQSEC2; KCNB1; KCNIP3; LGALS3; NFASC; PIK3R1; RAB3A; RAB3C; ARHGAP44; SNAP25; SPTBN4; STXBP1; ZDHHC22
GO:0001505	regulation of neurotransmitter levels	2.70	3.24e-06	2.93e-04	26/240	ACHE; BRSK1; CACNB2; CHRNB2; CPLX1; CPLX2; GRM4; HRH3; NAPB; PAH; PPFIA3; PTPRN2; RAB3A; RIMS2; SLC1A2; SNAP25; STX1A; STXBP1; SYN1; SYP; SYT13; SYT4; SYT5; SYT7; TPH2; UNC13A
GO:0006813	potassium ion transport	2.65	9.37e-05	4.76e-03	19/179	ANK3; ATP1A3; HCN2; HCN3; HCN4; KCNB1; KCNC1; KCNH2; KCNH4; KCNH6; KCNIP3; KCNJ6; KCNK3; KCNQ2; KCNU1; SLC12A5; SLC24A3; SLC24A5; SNAP25
GO:0051656	establishment of organelle localization	2.56	2.93e-05	1.79e-03	23/224	AP3B2; CACNB2; CHGA; CHRNB2; CPLX1; CPLX2; GRIA1; KIF5A; KIT; NAPB; PPFIA3; RAB3A; RIMS2; SNAP25; STX1A; STXBP1; SYN1; SYP; SYT13; SYT4; SYT5; SYT7; UNC13A
GO:0023061	signal release	2.51	1.18e-06	1.20e-04	32/318	BRSK1; BRSK2; CACNB2; CARTPT; CHGA; CHRNB2; CPLX1; CPLX2; FGFR1; GRM4; HFE; HRH3; IRS2; KCNB1; NAPB; PPFIA3; PTPRN2; RAB3A; RIMS2; SMPD3; SNAP25; STX1A; STXBP1; SYN1; SYP; SYT13; SYT4; SYT5; SYT7; TCF7L2; UNC13A; VGF
GO:0042391	regulation of membrane potential	2.38	1.53e-05	1.03e-03	28/293	ANK3; ATP1A3; CACNB2; CELF4; CHRNB2; FGF12; GABRG2; GRIA1; GRIK2; GRIN2C; HCN2; HCN3; HCN4; IGSF9B; KCNB1; KCNC1; KCNH2; KCNH4; KCNH6; KCNU1; MAPK8IP2; MPP2; NTSR2; P2RX6; RIMS2; SEZ6; SLC26A10; STX1A
GO:0060627	regulation of vesicle-mediated transport	2.34	3.07e-05	1.79e-03	27/288	CACNB2; CDK5R2; CHRNB2; CPLX1; CPLX2; DNAJC6; HFE; KCNB1; LGALS3; NAPB; PACSIN3; RAB25; RAB3A; RAB3C; ARHGAP44; RIMS2; SCAMP5; SMPD3; STX1A; STXBP1; SYN1; SYP; SYT4; SYT5; SYT7; VTN; WNT5A
GO:0050808	synapse organization	2.03	9.46e-04	3.21e-02	23/283	ACHE; ANK3; BSN; CACNB2; CAMK2B; CDK5R1; CHRNB2; CTNNA2; DLGAP3; IGSF9B; L1CAM; LRTM2; NFASC; RAB39B; RAB3A; ARHGAP44; SEZ6L; SEZ6; SLITRK1; SNCB; SYN1; UNC13A; WNT5A

PIK3CA_mis : 61 significant GO terms

GeneSet	description	enrichRatio	pValue	FDR	GeneRatio	geneSymbols
GO:0051383	kinetochore organization	7.95	3.60e-09	9.44e-08	10/11	CDT1; CENPA; CENPE; CENPF; CENPK; CENPN; CENPW; NDC80; NUF2; SMC4
GO:0034502	protein localization to chromosome	6.76	1.27e-12	4.70e-11	17/22	AURKB; BRCA2; BUB1B; KNL1; CDCA5; CDK1; CDT1; CENPA; ESCO2; EZH2; HASPIN; H2AFY2; MTBP; NDC80; PLK1; RAD21; TTK
GO:0061641	CENP-A containing chromatin organization	6.73	7.53e-08	1.91e-06	10/13	KNL1; CENPA; CENPI; CENPK; CENPM; CENPN; CENPW; HJURP; CENPU; OIP5
GO:0050000	chromosome localization	6.15	9.61e-13	3.73e-11	19/27	CCNB1; CDCA5; CDCA8; CDT1; CENPE; CENPF; CEP55; CHMP4C; DLGAP5; FAM83D; KIF14; KIF18A; KIF2C; KIFC1; NDC80; NUF2; PSRC1; RRS1; SPAG5
GO:0036297	interstrand cross-link repair	5.83	9.19e-06	1.87e-04	8/12	EME1; FANCA; FANCB; FANCE; FANCI; RAD51AP1; RAD51; UBE2T
GO:0006260	DNA replication	5.56	0.00e+00	0.00e+00	61/96	ACHE; ATAD5; BARD1; BLM; BRCA1; BRCA2; BRIP1; TICRR; RMI2; MCMDC2; CCNA2; CCNE1; CCNE2; CDC45; CDC6; CDC7; CDK1; CDT1; CHAF1B; CHEK1; CLSPN; DBF4; DDX11; DNA2; DSCC1; DTL; E2F7; E2F8; EME1; ESCO2; EXO1; FBXO5; FEN1; FGFR1; GINS1; GINS2; GINS4; GMNN; PCLAF; MCM10; MCM2; MCM4; MCM5; MCM6; MCM7; NFIA; TONSL; ORC1; PIF1; POLD1; POLE2; POLQ; RAD51; RECQL4; RFC4; RNASEH2A; RRM2B; RRM2; ALYREF; TOP1MT; WDHD1
GO:0007059	chromosome segregation	5.32	0.00e+00	0.00e+00	76/125	AURKB; BIRC5; BLM; BRCA1; BRIP1; BUB1B; BUB1; KNSTRN; RMI2; MCMDC2; KNL1; CCNB1; CCNE1; CCNE2; CDC20; CDC6; CDCA5; CDCA8; CDT1; CENPE; CENPF; CENPN; CENPW; CEP55; CHMP4C; DDX11; DLGAP5; DSCC1; ECT2; EME1; ESCO2; ESPL1; FAM83D; FBXO5; FEN1; HASPIN; HJURP; KIF14; KIF18A; KIF18B; KIF23; KIF2C; KIF4A; KIFC1; MAD2L1; MKI67; NCAPD2; NCAPG; NCAPH; NDC80; NEK2; NUF2; NUSAP1; OIP5; PLK1; PRC1; PSRC1; PTTG1; RACGAP1; RAD21; RAD51C; RRS1; SGO1; SGO2; SKA1; SKA2; SKA3; SMC4; SPAG5; SYCE2; TACC3; NDC1; TOP2A; TRIP13; TTK; ZWINT
GO:1902850	microtubule cytoskeleton organization involved in mitosis	5.12	2.22e-16	1.39e-14	31/53	AURKA; AURKB; SAPCD2; CCNB1; CDC20; CENPA; CENPE; CHMP4C; ESPL1; GPSM2; CEP126; KIF11; KIF23; KIF4A; KIFC1; MYBL2; NDC80; NEK2; NUF2; NUSAP1; PLK1; POC1A; PRC1; PSRC1; RACGAP1; STIL; STMN1; TACC3; TPX2; TTK; WDR62
GO:0032200	telomere organization	4.92	9.30e-10	2.91e-08	18/32	AURKB; BLM; BRCA2; CCNE1; CCNE2; DNA2; EXO1; FEN1; HMBOX1; MYC; NEK2; PIF1; POLD1; PRKDC; RAD51C; RAD51; RECQL4; RFC4
GO:0000075	cell cycle checkpoint	4.91	0.00e+00	0.00e+00	41/73	AURKA; AURKB; BLM; BRCA1; BRIP1; BRSK1; BUB1B; BUB1; TICRR; CCNB1; CDC20; CDC25C; CDC45; CDC6; CDK1; CDKN1A; CDT1; CENPF; CHEK1; CHMP4C; CLSPN; DNA2; DTL; E2F1; E2F7; E2F8; EME1; GTSE1; H2AFX; KNTC1; MAD2L1; NDC80; NEK11; ORC1; PLK1; PRKDC; TOP2A; TRIP13; TTK; WDR76; ZWINT
GO:0045023	G0 to G1 transition	4.71	2.30e-04	3.74e-03	7/13	BRCA1; CDC7; CHEK1; E2F1; EZH2; RAD51; RRM2
GO:0071166	ribonucleoprotein complex localization	4.71	2.30e-04	3.74e-03	7/13	DDX25; DDX39A; HHEX; NUP210; RRS1; ALYREF; NDC1
GO:0007051	spindle organization	4.64	1.11e-16	8.22e-15	35/66	ASPM; AURKA; AURKB; KNSTRN; AUNIP; CCNB1; CDC20; CENPE; CEP72; CHMP4C; ESPL1; FBXO5; GPSM2; WASHC5; CEP126; KIF11; KIF23; KIF4A; KIFC1; MYBL2; NDC80; NEK2; NUF2; PLK1; POC1A; PRC1; PSRC1; RACGAP1; SPAG5; STIL; STMN1; TACC3; TPX2; TTK; WDR62
GO:0044839	cell cycle G2/M phase transition	4.64	0.00e+00	0.00e+00	44/83	ATAD5; AURKA; AURKB; BLM; BRCA1; BRSK1; BRSK2; TICRR; CCNA2; CCNB1; CCNB2; CDC25A; CDC25B; CDC25C; CDC6; CDC7; CDK1; CDKN1A; CENPF; CEP72; CHEK1; CHMP4C; CIT; CLSPN; DTL; DYRK3; FBXO5; FOXM1; GTSE1; HMMR; AJUBA; KIF14; MELK; NEK10; NEK2; ORC1; PKMYT1; PLK1; PLK4; RAD21; RAD51C; RECQL4; SKP2; TPX2
GO:0000910	cytokinesis	4.45	7.75e-14	3.94e-12	30/59	ANK3; ANLN; AURKA; AURKB; BRCA2; CDC25B; CDC6; CDT1; CENPA; CEP55; CHMP4C; CIT; CKAP2; CSPP1; DRD2; E2F7; E2F8; ECT2; ESPL1; WASHC5; KIF14; KIF20A; KIF23; KIF4A; NUSAP1; PLK1; PRC1; RACGAP1; SEPT3; STMN1
GO:0006302	double-strand break repair	4.43	2.22e-16	1.39e-14	36/71	BARD1; BLM; BRCA1; BRCA2; BRIP1; PARPBP; RMI2; AUNIP; MCMDC2; CDC45; CDC7; CDCA5; CHEK1; DDX11; DEK; DNA2; EME1; ESCO2; EXO1; FANCB; FEN1; FOXM1; GINS2; GINS4; H2AFX; TONSL; POLQ; PRKDC; RAD21; RAD51AP1; RAD51C; RAD51; RAD54B; RAD54L; RECQL4; TRIP13
GO:0001539	cilium or flagellum-dependent cell motility	4.37	8.77e-06	1.83e-04	11/22	DRC1; CCDC65; DNAH2; DNAH3; DNAH6; DNAH7; SPEF1; TEKT1; TEKT2; TEKT3; CFAP57
GO:0051653	spindle localization	4.37	1.57e-04	2.71e-03	8/16	ASPM; SAPCD2; CENPA; ESPL1; GPSM2; LLGL2; NDC80; NUSAP1
GO:0006301	postreplication repair	4.37	1.10e-03	1.50e-02	6/12	BRCA1; DTL; PCLAF; POLD1; POLE2; RFC4
GO:0071103	DNA conformation change	4.28	0.00e+00	0.00e+00	48/98	ASF1B; BLM; BRIP1; KNL1; CCNB1; CDC45; CDCA5; CDK1; CENPA; CENPI; CENPK; CENPM; CENPN; CENPW; CHAF1B; CHD5; DDX11; DNA2; GINS1; GINS2; GINS4; H2AFX; H2AFY2; HELLS; HHEX; HIST2H3C; HJURP; HMGB2; MCM2; MCM4; MCM6; MCM7; CENPU; NCAPD2; NCAPG2; NCAPG; NCAPH; NUSAP1; OIP5; PARP10; PIF1; RAD51; RAD54B; RAD54L; RECQL4; SMC4; TOP1MT; TOP2A
GO:0031023	microtubule organizing center organization	4.27	1.18e-09	3.55e-08	21/43	AURKA; BRCA1; BRCA2; BRSK1; CCNF; CDK1; CEP72; CHEK1; CHMP4C; CNTLN; PCLAF; KIF11; NEK2; PARD6A; PLK1; PLK4; POC1A; SGO1; STIL; TRIM37; WDR62
GO:1904029	regulation of cyclin-dependent protein kinase activity	4.13	3.08e-11	1.05e-09	26/55	BLM; CCNA2; CCNB1; CCNB2; CCNE1; CCNE2; CCNF; CCNI2; CCNO; CDC25A; CDC25C; CDC6; CDK5R1; CDK5R2; CDKN1A; CDKN2C; CDKN2D; CDKN3; CKS1B; CKS2; HHEX; NR2F2; PDGFB; PKMYT1; PLK1; PSRC1
GO:0000726	non-recombinational repair	4.12	2.67e-04	4.17e-03	8/17	BARD1; BLM; BRCA1; AUNIP; DEK; H2AFX; POLQ; PRKDC
GO:0001578	microtubule bundle formation	4.07	2.01e-11	7.13e-10	27/58	ARMC4; CFAP43; DRC1; CFAP206; CFAP157; CCDC103; CCDC114; CCDC65; DNAH7; DNAI2; DNAJB13; HYDIN; KIF20A; LRGUK; LRRC49; DNAAF1; LRRC6; NAV1; NCKAP5; PLK1; PRC1; PSRC1; RSPH1; RSPH4A; TEKT2; TRIM46; ZMYND10
GO:0044772	mitotic cell cycle phase transition	4.05	0.00e+00	0.00e+00	89/192	ANLN; ATAD5; AURKA; AURKB; BLM; BRCA1; BRSK1; BRSK2; BUB1B; BUB1; TICRR; CCNA2; CCNB1; CCNB2; CCNE1; CCNE2; CDC20; CDC25A; CDC25B; CDC25C; CDC45; CDC6; CDC7; CDCA5; CDK1; CDKN1A; CDKN2C; CDKN2D; CDKN3; CDT1; CENPE; CENPF; CEP72; CHMP4C; CIT; CKS1B; CKS2; CLSPN; DBF4; DLGAP5; DTL; E2F1; E2F7; E2F8; ESPL1; EZH2; FBXO5; FOXM1; GMNN; GTSE1; HMMR; IQGAP3; AJUBA; KIF14; KNTC1; MAD2L1; MCM10; MCM2; MCM4; MCM5; MCM6; MCM7; MELK; MTBP; MYC; NDC80; NEK11; NEK2; ORC1; PKMYT1; PLK1; PLK4; POLE2; PRKDC; RAD21; RAD51C; RBL1; RECQL4; RRM2; SKP2; TACC3; TPX2; TRIP13; TTK; TYMS; UBE2C; UBE2S; ZFP36L1; ZFP36L2
GO:1901987	regulation of cell cycle phase transition	3.76	0.00e+00	0.00e+00	64/149	ANLN; ATAD5; AURKA; AURKB; BLM; BRCA1; BRSK1; BUB1B; BUB1; TICRR; CCNB1; CCNE1; CDC20; CDC25A; CDC25B; CDC25C; CDC45; CDC6; CDC7; CDCA5; CDK1; CDKN1A; CDKN2D; CDT1; CENPE; CENPF; CEP72; CHEK1; CHMP4C; CLSPN; DLGAP5; DTL; DYRK3; E2F1; E2F7; E2F8; ESPL1; EZH2; FAM83D; FBXO5; GTSE1; HMMR; KIF14; KNTC1; MAD2L1; MTBP; NDC80; NEK10; NEK11; NEK2; ORC1; PLK1; PLK4; PRKDC; RAD21; RAD51C; RBL1; RECQL4; TPX2; TRIP13; TTK; UBE2C; ZFP36L1; ZFP36L2
GO:0006284	base-excision repair	3.75	2.93e-03	3.83e-02	6/14	DNA2; FEN1; NEIL3; POLD1; POLQ; RECQL4
GO:0048285	organelle fission	3.72	0.00e+00	0.00e+00	92/216	ANLN; ASPM; AURKA; AURKB; BLM; BRCA2; BRIP1; BUB1B; BUB1; KNSTRN; MCMDC2; CCNA2; CCNB1; CCNB2; CCNE1; CCNE2; CCNF; CCNI2; CCNO; CDC20; CDC25B; CDC25C; CDC6; CDCA5; CDCA8; CDT1; CENPE; CENPF; CEP55; CHEK1; CHMP4C; CKS2; DLGAP5; DSCC1; EME1; ESPL1; MTFR2; FANCA; FBXO5; HASPIN; WASHC5; KIF11; KIF14; KIF18A; KIF18B; KIF23; KIF2C; KIF4A; KIFC1; KNTC1; MAD2L1; MKI67; MND1; MTBP; MTFR1; MYBL1; MYBL2; NCAPD2; NCAPG; NCAPH; NDC80; NEK2; NUF2; NUSAP1; PDGFB; PKMYT1; PLK1; PRC1; PSRC1; PTTG1; RACGAP1; RAD21; RAD51C; RAD51; RAD54B; RRS1; SEC16B; SGO1; SGO2; SMC4; SPAG5; SYCE2; TACC3; NDC1; TOP2A; TPX2; TRIP13; TTK; UBE2C; UBE2S; WNT5A; ZWINT
GO:0010948	negative regulation of cell cycle process	3.70	0.00e+00	0.00e+00	47/111	AURKA; AURKB; BLM; BRCA1; BRSK1; BUB1B; BUB1; TICRR; CCNB1; CCNF; CDC20; CDC25C; CDC6; CDC7; CDK1; CDKN1A; CDKN2D; CDT1; CENPF; CHEK1; CHMP4C; CLSPN; DTL; E2F1; E2F7; E2F8; ESPL1; EZH2; FBXO5; GTSE1; MAD2L1; MTBP; NDC80; NEK2; ORC1; PLK1; PRKDC; PTTG1; RAD21; RAD51; RBL1; RRM2; TRIM37; TRIP13; TTK; ZFP36L1; ZFP36L2
GO:0044380	protein localization to cytoskeleton	3.58	3.99e-04	6.02e-03	9/22	ANLN; AURKA; CEP72; FAM83D; FAM83H; PARD6A; SPAG5; STIL; TTK
GO:0045930	negative regulation of mitotic cell cycle	3.56	8.88e-16	5.16e-14	46/113	AURKA; AURKB; BLM; BRCA1; BRSK1; BUB1B; BUB1; TICRR; CCNB1; CDC20; CDC25C; CDC6; CDK1; CDKN1A; CDT1; CENPF; CHEK1; CHMP4C; CLSPN; E2F1; E2F7; E2F8; EME1; EZH2; FBXO5; FZD3; GTSE1; KNTC1; MAD2L1; MTBP; NDC80; NEK11; NKX3-1; ORC1; PLK1; PRKDC; PTTG1; RAD21; RBL1; SCRIB; TOP2A; TRIP13; TTK; ZFP36L1; ZFP36L2; ZWINT
GO:0006310	DNA recombination	3.41	7.61e-13	3.10e-11	39/100	ATAD5; BLM; BRCA1; BRCA2; BRIP1; PARPBP; RMI2; AUNIP; MCMDC2; CDC45; CDC7; CHEK1; CLCF1; EME1; EXO1; FANCB; FEN1; GINS2; GINS4; H2AFX; HMGB2; KPNA2; MND1; TONSL; PGBD5; PIF1; POLQ; PRKDC; RAD21; RAD51AP1; RAD51C; RAD51; RAD54B; RAD54L; RECQL4; TFRC; ALYREF; TOP2A; TRIP13
GO:0044843	cell cycle G1/S phase transition	3.37	1.60e-13	7.22e-12	42/109	AURKA; CCNA2; CCNB1; CCNE1; CCNE2; CDC25A; CDC25C; CDC45; CDC6; CDC7; CDK1; CDKN1A; CDKN2C; CDKN2D; CDKN3; CDT1; DBF4; E2F1; E2F7; E2F8; EZH2; FAM83D; FBXO5; GMNN; GTSE1; IQGAP3; KIF14; MCM10; MCM2; MCM4; MCM5; MCM6; MCM7; MTBP; MYC; ORC1; POLE2; PRKDC; RBL1; RRM2; SKP2; TYMS
GO:0033044	regulation of chromosome organization	3.36	6.57e-13	2.81e-11	40/104	ATAD2; AURKB; BRCA1; BUB1B; BUB1; RMI2; CCNB1; CDC20; CDC45; CDC6; CDCA5; CDT1; CENPE; CENPF; CHEK1; DDX11; DLGAP5; DNMT3B; ESPL1; FBXO5; FEN1; HMBOX1; JDP2; MAD2L1; MCM2; MKI67; MYC; NDC80; NEK2; PARP10; PHF19; PIF1; PLK1; PRDM12; PTTG1; RAD21; TACC3; TOP2A; TRIP13; TTK
GO:0042770	signal transduction in response to DNA damage	3.36	4.12e-07	9.58e-06	20/52	ATAD5; AURKA; BRCA1; BRCA2; CCNB1; CDC25C; CDK1; CDKN1A; CHEK1; DTL; DYRK3; E2F1; E2F7; E2F8; FOXM1; GTSE1; NDRG1; PLK1; PMAIP1; PRKDC
GO:0007018	microtubule-based movement	3.35	2.00e-15	1.08e-13	49/128	AP3B2; ARMC4; DRC1; MAATS1; CFAP206; CCDC103; CCDC114; CFAP53; CCDC65; CENPE; CNIH2; DLGAP5; DNAH12; DNAH2; DNAH3; DNAH6; DNAH7; DNAI2; HYDIN; KIF11; KIF14; KIF15; KIF18A; KIF18B; KIF19; KIF20A; KIF21A; KIF23; KIF2C; KIF4A; KIF5A; KIFC1; KIFC2; DNAAF1; LRRC6; MAK; NME5; CFAP221; RACGAP1; ROPN1L; RSPH4A; SPA17; TEKT1; TEKT2; TEKT3; TRIM46; WDR34; WDR63; WDR78
GO:0071824	protein-DNA complex subunit organization	3.20	2.15e-09	6.26e-08	30/82	ANP32E; ASF1B; BRF2; MCMDC2; KNL1; CDC45; CDT1; CENPA; CENPE; CENPF; CENPI; CENPK; CENPM; CENPN; CENPW; CHAF1B; CHD5; GMNN; H2AFX; H2AFY2; HELLS; HIST2H3C; HJURP; HMGB2; HNF1B; MCM2; CENPU; MYC; OIP5; RAD51
GO:0022406	membrane docking	3.20	2.01e-06	4.42e-05	19/52	CDK1; CEP72; CPLX2; GRAMD2A; KCNB1; NEK2; NPHP1; PLK1; PLK4; PPFIA3; RAB3C; SNAP25; SNPH; STX1A; STX1B; STXBP1; SYTL2; TSNARE1; UNC13A
GO:0006997	nucleus organization	3.18	1.66e-04	2.82e-03	12/33	CCNB1; CCNB2; CDK1; CELF3; CEP55; CHD5; CHMP4C; DYRK3; GOLM1; HMGB2; PLK1; NDC1
GO:0051321	meiotic cell cycle	3.16	9.24e-14	4.42e-12	47/130	ASPM; AURKA; BLM; BRCA2; BRIP1; BUB1B; BUB1; MCMDC2; CCNE1; CCNE2; CDC20; CDC25A; CDC25B; CDC25C; CKS2; EME1; ESPL1; EXO1; FANCA; FBXO5; H2AFX; WASHC5; KIF18A; MND1; MYBL1; NCAPD2; NCAPH; NEK2; NUF2; PKMYT1; PLK1; PTTG1; RAD21; RAD51C; RAD51; RAD54B; RAD54L; RSPH1; SGO1; SGO2; SMC4; SYCE2; NDC1; TOP2A; TRIP13; TTK; WNT5A
GO:0045787	positive regulation of cell cycle	3.07	0.00e+00	0.00e+00	67/191	ASCL1; ATAD5; AURKA; AURKB; BRCA1; BRCA2; CCNA2; CCNB1; CCNB2; CCNE1; CCNE2; CCNF; CCNI2; CCNO; CDC25A; CDC25B; CDC25C; CDC45; CDC6; CDC7; CDCA5; CDK1; CDK5R1; CDKN1A; CDT1; CHEK1; CIT; CKS1B; CKS2; CSPP1; DDX11; DLGAP5; DRD2; DTL; DYRK3; E2F1; E2F7; E2F8; ECT2; ESPL1; EZH2; FAM83D; FBXO5; FEN1; FGFR1; GPSM2; GTSE1; INSM1; KIF14; KIF23; MAD2L1; MTBP; NDC80; NKX3-1; NUSAP1; PDGFB; PLK4; POC1A; PSRC1; RACGAP1; RAD21; RAD51C; RECQL4; SLC6A4; SPAG5; UBE2C; WNT5A
GO:0071826	ribonucleoprotein complex subunit organization	3.00	3.15e-04	4.84e-03	12/35	BOP1; TICRR; CELF3; CELF4; DYRK3; AGO2; EIF3H; MTERF3; PIH1D2; PRKAA2; PSIP1; RRS1
GO:0006338	chromatin remodeling	2.97	2.10e-05	4.06e-04	17/50	ACTL6B; ANP32E; KNL1; CENPA; CENPI; CENPK; CENPM; CENPN; CENPW; CHD5; CHEK1; HELLS; HJURP; HMGB2; CENPU; MYC; OIP5
GO:0032886	regulation of microtubule-based process	2.89	2.41e-09	6.77e-08	35/106	APC2; ARMC4; AURKA; BRCA1; DRC1; CCDC65; CCNF; CDK5R1; CHEK1; CHMP4C; CKAP2; CNIH2; GPSM2; KIF11; KIF18A; DNAAF1; NEK2; PLK1; PLK4; POC1A; PRKAA2; PSRC1; SKA1; SKA2; SKA3; SPAG5; SPEF1; STIL; STMN1; STMN3; STMN4; TACC3; TPX2; TRIM37; TRIM46
GO:0031109	microtubule polymerization or depolymerization	2.81	2.88e-05	5.33e-04	18/56	APC2; CDK5R1; CKAP2; FBXO5; KIF14; KIF18A; KIF18B; KIF19; KIF2C; NCKAP5; PSRC1; SKA1; SKA2; SKA3; SPEF1; STMN1; STMN3; STMN4
GO:0072331	signal transduction by p53 class mediator	2.78	3.99e-07	9.56e-06	27/85	ATAD5; AURKA; AURKB; BOP1; BRCA1; BRCA2; CCNB1; CDC25C; CDK1; CDKN1A; CHD5; CHEK1; DYRK3; E2F1; E2F2; E2F7; E2F8; ELL3; FOXM1; GTSE1; MAPK11; NDRG1; PMAIP1; PYCARD; RRM2B; RRS1; TPX2
GO:0071897	DNA biosynthetic process	2.77	2.20e-05	4.17e-04	19/60	AURKB; BLM; CDKN2D; CENPF; DSCC1; DTL; HMBOX1; PCLAF; LIN9; MYC; NEK2; PDGFB; PIF1; POLD1; POLE2; POLQ; RFC4; TK1; TYMS
GO:2001020	regulation of response to DNA damage stimulus	2.69	3.32e-06	7.11e-05	24/78	ATAD5; BLM; BRCA1; DDIAS; PARPBP; RMI2; AUNIP; CDKN2D; CHEK1; DDX11; DEK; DYRK3; ELL3; FANCB; FBXO5; FOXM1; H2AFX; MYC; NKX3-1; PMAIP1; POLQ; RAD51AP1; RAD51; WDR76
GO:0006333	chromatin assembly or disassembly	2.64	4.73e-05	8.56e-04	19/63	ASF1B; KNL1; CENPA; CENPI; CENPK; CENPM; CENPN; CENPW; CHAF1B; H2AFX; H2AFY2; HELLS; HIST2H3C; HJURP; HMGB2; MCM2; CENPU; OIP5; PARP10
GO:0044782	cilium organization	2.62	1.96e-10	6.37e-09	47/157	ARMC4; CFAP43; CFAP126; DRC1; CATIP; CFAP206; CFAP157; CCDC103; CCDC114; CFAP53; CCDC13; CCDC65; CCNO; CDK1; CELSR3; CEP72; DNAH7; DNAI2; DNAJB13; FOXJ1; HYDIN; IQUB; KCTD17; CEP126; KIF19; LRGUK; LRRC49; DNAAF1; LRRC6; MAK; NEK2; NME5; NPHP1; CFAP221; PLK1; PLK4; POC1A; RSPH1; RSPH4A; SEPT3; TEKT1; TEKT2; TEKT3; VANGL2; WDR34; WDR90; ZMYND10
GO:0140029	exocytic process	2.61	5.34e-04	7.76e-03	14/47	CPLX2; KCNB1; NAPB; PPFIA3; RAB3C; SCRIB; SNAP25; SNPH; STX1A; STX1B; STXBP1; SYT9; SYTL2; UNC13A
GO:0051052	regulation of DNA metabolic process	2.56	2.60e-09	7.07e-08	43/147	ATAD5; AURKB; BLM; BRCA1; BRCA2; PARPBP; TICRR; RMI2; AUNIP; CCNA2; CDC6; CDC7; CDK1; CDT1; CHEK1; CLCF1; DBF4; DDX11; DEK; DNA2; DSCC1; E2F7; E2F8; ESCO2; FANCB; FBXO5; FGFR1; FOXM1; GMNN; H2AFX; HMBOX1; KPNA2; MYC; NEK2; PDGFB; PIF1; POLQ; RAD51AP1; RAD51; RECQL4; RFC4; TFRC; ALYREF
GO:0051302	regulation of cell division	2.37	1.74e-05	3.46e-04	26/96	ASPM; AURKA; AURKB; BLM; BRCA2; CDC25B; CDC6; CHMP4C; CIT; CSPP1; DRD2; E2F7; E2F8; ECT2; KIF14; KIF18B; KIF20A; KIF23; MACC1; MYC; NKX3-1; PDGFB; PLK1; PRC1; RACGAP1; RBL1
GO:0022613	ribonucleoprotein complex biogenesis	2.35	1.60e-03	2.14e-02	14/52	BOP1; TICRR; CELF3; CELF4; DCAF13; AGO2; EIF3H; EXOSC4; ISG20; MTERF3; PIH1D2; PRKAA2; PSIP1; RRS1
GO:0031503	protein-containing complex localization	2.19	9.56e-04	1.34e-02	18/72	BIRC5; CEP72; CNIH2; DDX25; DDX39A; GPC4; HASPIN; HHEX; KIF5A; MAK; NUP210; RRS1; SCRIB; SNAP25; STX1B; ALYREF; NDC1; WDR34
GO:0090305	nucleic acid phosphodiester bond hydrolysis	2.16	8.29e-04	1.18e-02	19/77	ATAD5; BOP1; DNA2; AGO2; EME1; EXO1; EXOSC4; FEN1; HMGB2; RIDA; ISG20; LACTB2; REXO5; PGBD5; POLD1; POP1; RFC4; RNASEH2A; RRS1
GO:0010639	negative regulation of organelle organization	2.15	1.66e-06	3.76e-05	40/163	APC2; ARFGEF1; ATAD2; AURKB; BRCA1; BUB1B; BUB1; ARPIN; CCNB1; CCNF; CDC20; CDT1; CENPF; CHEK1; CKAP2; DNMT3B; ESPL1; FBXO5; MAD2L1; MAK; MCM2; MTBP; NDC80; NEK2; PIF1; PLEKHH2; PLK1; PTTG1; RAD21; CARMIL2; SPEF1; STMN1; SYT4; TACSTD2; TMOD2; TMSB15A; TMSB15B; TOP2A; TRIM37; TRIP13; TTK
GO:0051656	establishment of organelle localization	2.07	1.23e-07	3.03e-06	53/224	AP3B2; SAPCD2; CACNB2; CCNB1; CDCA5; CDCA8; CDT1; CENPA; CENPE; CENPF; CEP55; CHGA; CHMP4C; CHRNB2; CNIH2; CPLX2; DLGAP5; DOC2A; DRD2; ESPL1; FAM83D; GPSM2; KIF14; KIF18A; KIF23; KIF2C; KIF5A; KIFC1; LLGL2; NAPB; NDC80; NUF2; NUSAP1; PPFIA3; PSRC1; RIMS2; RRS1; SCRIB; SEC16B; SLIT1; SNAP25; SNPH; SPAG5; STX1A; STX1B; STXBP1; SYN1; SYP; SYT4; SYT5; SYT9; TRIM46; UNC13A
GO:0099504	synaptic vesicle cycle	2.06	9.66e-05	1.71e-03	29/123	BRSK1; BRSK2; BSN; CACNB2; CDK5R1; CHRNB2; CPLX2; DDC; DNAJC6; DOC2A; DRD2; NAPB; NRXN1; PPFIA3; RIMS2; SCRIB; SNAP25; SNCB; SNPH; STON2; STX1A; STX1B; STXBP1; SYN1; SYP; SYT4; SYT5; SYT9; UNC13A
GO:0017156	calcium ion regulated exocytosis	2.04	4.55e-04	6.73e-03	24/103	BAIAP3; CACNB2; CDK5R2; CHRNB2; CPLX2; DOC2A; DRD2; KCNB1; NAPB; PPFIA3; RIMS2; SCAMP5; SCRIB; SNAP25; SNPH; STX1A; STX1B; STXBP1; SYN1; SYP; SYT4; SYT5; SYT9; UNC13A
GO:0099003	vesicle-mediated transport in synapse	2.02	2.43e-04	3.88e-03	27/117	AP3B2; CACNB2; CHRNB2; CNIH2; CPLX2; DNAJC6; DOC2A; DRD2; KIF5A; NAPB; PPFIA3; RIMS2; SCRIB; SNAP25; SNCB; SNPH; STON2; STX1A; STX1B; STXBP1; SYN1; SYP; SYT4; SYT5; SYT9; TRIM46; UNC13A

Summary:
Marker	TP53_LOF	TP53_mis	CDH1_LOF	GATA3_LOF	PIK3CA_mis
Signif_GO_terms	62	44	31	24	61

Guided Factor Analysis on TCGA BRCA Gene Expression Data

-- Normalization: TMM, Guides: LOF and Missense Mutations Separated

Yifan Zhou (zhouyf@uchicago.edu)

2022-03-23