1 Single cell expression data

Source:
Genome-wide CRISPR Screens in Primary Human T Cells Reveal Key Regulators of Immune Function, GEO accession: GSE119450.

Perturbations:
CRISPR knock-out of 20 genes (2 gRNAs per gene) + 8 non-targeting gRNAs. Guide conditions were defined on the target gene level; target genes were either found to regulate T cell responses in the genome-wide screens, or known checkpoint genes.
Guide RNAs were introduced into T cells through a novel procedure called sgRNA lentiviral infection with Cas9 protein electroporation (SLICE).

Cells:
Primary human CD8+ T cells from two healthy donors, without T cell receptor (TCR) stimulation.
Cells from 2 donors were pooled together into 1 analysis. All cells have only a single type of gRNA readout. Quality control resulted in 10644 cells.

Genes:
Top 6000 genes ranked by the multinomial deviance statistics were kept.

Normalization:
Deviance residual transformation.
Batch effect, unique UMI count, library size, and mitochondria percentage were all corrected for. The corrected and scaled expression data were used as input for subsequent factor analysis.

2 Guided results

Here, our "guide", \(G\) matrix, consists of 21 types (20 genes + negative control) of KO conditions across cells.

In each case, Gibbs sampling was conducted for 3000 iterations, and the posterior mean estimates were averaged over the last 1000 iterations.

2.1 SVD Initialization

2.1.1 Local False Sign Rate (LFSR)

For a given GSFA inference result, we can estimate the effect a certain KO condition \(m\) has on the expression of gene \(j\) by computing the LFSR of \(\beta_{m\cdot} \cdot W_{j\cdot}\).

Number of genes that passed GSFA LFSR < 0.05 under each perturbation:

GSFA, # of genes that passed LFSR cutoff of 0.05:
KO	ARID1A	BTLA	C10orf54	CBLB	CD3D	CD5	CDKN1B
Num_genes	0	0	0	0	0	0	317
KO	DGKA	DGKZ	HAVCR2	LAG3	LCP2	MEF2D	NonTarget
Num_genes	0	0	0	0	0	39	0
KO	PDCD1	RASA2	SOCS1	STAT6	TCEB2	TMEM222	TNFRSF9
Num_genes	102	197	0	0	319	0	0

Number of genes that passed t-test FDR < 0.05 under each perturbation:

Welch's t-test, # of genes that passed FDR cutoff of 0.05:
KO	ARID1A	BTLA	C10orf54	CBLB	CD3D	CD5	CDKN1B
Num_genes	5	1	1	8	1	0	1
KO	DGKA	DGKZ	HAVCR2	LAG3	LCP2	MEF2D	NonTarget
Num_genes	0	0	0	0	1	1	0
KO	PDCD1	RASA2	SOCS1	STAT6	TCEB2	TMEM222	TNFRSF9
Num_genes	2	0	0	1	30	0	0

2.1.2 Estimate of Factor ~ Perturbation Associations (\(\beta\))

2.1.3 Factor ~ KO Posterior Association

2.1.4 Beta PIP vs P-Value

2.1.5 Correlation within Factors

2.1.6 Correlation w/ Factors from Stimulated Result

3 Gene Ontology Enrichment Analysis by Factor

Target genes: Genes w/ non-zero loadings in each factor (PIP cutoff at 0.95);
Backgroud genes: all 6000 genes used in factor analysis;
Statistical test: hypergeometric test (over-representation test);
Only GO terms/pathways that satisfy fold change \(\geq\) 2 and test FDR \(<\) 0.05 are shown below.

3.1 GO Slim Over-Representation Analysis

Gene sets: Gene ontology "Biological Process" (non-redundant).

Factor 1 : 93 significant GO terms

GeneSet	description	enrichRatio	pValue	FDR	GeneRatio	geneSymbols
GO:0070972	protein localization to endoplasmic reticulum	6.17	0.00e+00	0.00e+00	61/122	RPL22; RPL11; RPS8; RPL5; RPS27; RPS7; RPS27A; RPL31; RPL32; RPL15; RPL14; RPL29; RPL24; RPL35A; RPL9; RPL34; RPS3A; RPL37; RPS23; RPS14; RPL10A; RPS12; INSIG1; RPL10; RPS20; RPL7; RPL30; RPS6; RPL7A; RPLP2; RPL27A; RPS13; RPS25; RPS24; RPL41; RPL6; RPL21; RPS29; SRP14; RPS27L; RPL4; RPLP1; RPS17; RPS15A; RPL13; RPL26; RPL23A; RPL23; RPL19; RPL27; RPL38; RPS21; RPL36; RPS28; RPL18A; UBA52; RPS16; RPS19; RPL18; RPL13A; RPS11; RPS5
GO:0042092	type 2 immune response	6.17	6.11e-04	7.33e-03	5/10	DENND1B; CD74; ANXA1; GATA3; BATF
GO:1990868	response to chemokine	5.81	2.20e-05	5.00e-04	8/17	CXCR4; CXCR6; FAM65B; CCL5; CCL3; CCL3L3; CCL4L2; CCR7
GO:0002181	cytoplasmic translation	5.39	2.22e-16	2.69e-14	31/71	RPL11; DPH5; RPL31; RPL32; RPL15; RPL29; RPL24; RPL35A; RPL9; RPS23; RPL10A; EIF2S3; RPL30; EIF3E; EIF3H; YBX3; RPL41; RPL6; RPS29; RPLP1; RPL26; RPL19; RPL38; RPS21; EEF2; RPL36; RPS28; RPL18A; RPL18; RPL13A; EIF3L
GO:0006959	humoral immune response	5.23	8.29e-08	5.03e-06	14/33	PTPRC; CD55; GNLY; RBPJ; HLA-DQB1; RPL30; CD81; GATA3; GAPDH; GPR183; C1QBP; CCR7; BST2; RPS19
GO:0006413	translational initiation	5.17	0.00e+00	0.00e+00	67/160	RPL22; RPL11; RPS8; RPL5; RPS27; RPS7; EIF2AK2; RPS27A; RPL31; RPL32; RPL15; RPL14; RPL29; RPL24; RPL35A; RPL9; RPL34; RPS3A; RPL37; RPS23; RPS14; NPM1; RPL10A; RPS12; EIF2S3; RPL10; RPS20; RPL7; RPL30; PABPC1; EIF3E; EIF3H; RPS6; RPL7A; RPLP2; RPL27A; RPS13; RPS25; RPS24; RPL41; RPL6; RPL21; RPS29; RPS27L; RPL4; RPLP1; RPS17; RPS15A; RPL13; RPL26; RPL23A; CCL5; RPL23; RPL19; RPL27; RPL38; RPS21; RPL36; RPS28; RPL18A; UBA52; RPS16; RPS19; RPL18; RPL13A; RPS11; RPS5; EIF3L
GO:0050918	positive chemotaxis	5.14	1.67e-03	1.67e-02	5/12	HMGB2; LGALS3; CORO1A; CCL5; CCL3
GO:0034113	heterotypic cell-cell adhesion	5.08	2.07e-04	3.15e-03	7/17	CD58; CD2; PTPRC; ITGA4; PERP; CD44; ITGB1
GO:0019233	sensory perception of pain	4.75	2.54e-03	2.28e-02	5/13	FAM134B; F2R; FYN; CCL3; MAPK1
GO:0090150	establishment of protein localization to membrane	4.15	0.00e+00	0.00e+00	69/205	RPL22; RPL11; RPS8; RPL5; RPS27; RPS7; YWHAQ; SPTBN1; RPS27A; MAL; RPL31; RPL32; RPL15; RPL14; RPL29; RPL24; RPL35A; RPL9; RPL34; RPS3A; RPL37; RPS23; RPS14; GNB2L1; RPL10A; FYN; RPS12; RPL10; RPS20; RPL7; RPL30; RPS6; STOM; RPL7A; RPLP2; RPL27A; RPS13; RPS25; RPS24; RPL41; RPL6; RPL21; GZMB; RPS29; SRP14; RPS27L; RPL4; RPLP1; RPS17; RPS15A; RPL13; RPL26; RPL23A; RPL23; RPL19; RPL27; RPL38; PRNP; RPS21; RPL36; RPS28; RPL18A; UBA52; RPS16; RPS19; RPL18; RPL13A; RPS11; RPS5; YWHAH
GO:0006968	cellular defense response	4.11	9.32e-04	1.03e-02	7/21	FCMR; GNLY; LSP1; ITGB1; PRF1; KLRG1; KLRC2
GO:0060326	cell chemotaxis	3.95	1.77e-09	1.43e-07	24/75	FCER1G; CXCR4; CXCR6; LEF1; HMGB2; ITGA1; CD74; FAM65B; GPSM3; FGFR1; ANXA1; JAML; ADAM8; GPR183; LGALS3; CORO1A; CKLF; C1QBP; CCL5; CCL3; CCL3L3; CCL4L2; CCR7; RPS19
GO:0032615	interleukin-12 production	3.90	2.98e-03	2.52e-02	6/19	SLAMF1; FOXP1; TIGIT; LTB; C1QBP; CCR7
GO:0032963	collagen metabolic process	3.90	2.98e-03	2.52e-02	6/19	RAP1A; F2R; CTSD; VIM; ITGB1; CST3
GO:0030101	natural killer cell activation	3.86	1.39e-04	2.25e-03	10/32	ZNF683; PTPN22; CD2; SLAMF7; PTPRC; ID2; NCR3; PRDM1; RAB27A; CORO1A
GO:0001773	myeloid dendritic cell activation	3.86	7.04e-03	4.92e-02	5/16	CD2; SLAMF1; RBPJ; CAMK4; BATF
GO:0043583	ear development	3.74	1.85e-04	2.87e-03	10/33	SLC4A7; RBPJ; FAM65B; AHI1; INSIG1; FGFR1; GATA3; MAF; RPL38; MAPK1
GO:0070670	response to interleukin-4	3.70	3.97e-03	3.18e-02	6/20	LEF1; TCF7; HSP90AB1; GATA3; TUBA1B; CORO1A
GO:0006401	RNA catabolic process	3.65	0.00e+00	0.00e+00	74/250	RPL22; TNFRSF1B; RPL11; RPS8; SERBP1; RPL5; RPS27; RPS7; RPS27A; RPL31; RPL32; RPL15; RPL14; RPL29; RPL24; RPL35A; RPL9; RPL34; RPS3A; RPL37; RPS23; RPS14; NPM1; RPL10A; RPS12; RPL10; RPS20; RPL7; RPL30; PABPC1; EIF3E; RPS6; RPL7A; RPLP2; RPL27A; RPS13; ATM; RPS25; VIM; RPS24; YBX3; PYM1; RPL41; RPL6; UBC; RPL21; APEX1; RPS29; PATL2; RPS27L; RPL4; RPLP1; RPS17; ISG20; CARHSP1; RPS15A; RPL13; RPL26; RPL23A; RPL23; RPL19; RPL27; ERN1; RPL38; RPS21; RPL36; RPS28; RPL18A; UBA52; RPS16; RPS19; RPL18; RPL13A; RPS11; RPS5
GO:0002526	acute inflammatory response	3.52	1.27e-03	1.34e-02	8/28	FCER1G; CD55; IL6ST; CD81; GATA3; ADAM8; C1QBP; CCR7
GO:0098742	cell-cell adhesion via plasma-membrane adhesion molecules	3.52	5.18e-03	3.77e-02	6/21	CD84; SELL; EMB; JAML; ITGB1; PECAM1
GO:0050900	leukocyte migration	3.47	3.77e-11	3.92e-09	34/121	CD58; CD2; CD84; FCER1G; SELL; GYPC; CXCR4; ITGA4; PTGER4; ITGA1; CD74; FAM65B; GPSM3; FYN; MYO1G; DOK2; ANXA1; CD44; JAML; GATA3; ITGB1; ADAM8; GPR183; LGALS3; CORO1A; CKLF; C1QBP; CCL5; CCL3; CCL3L3; CCL4L2; CCR7; PECAM1; RPS19
GO:0035270	endocrine system development	3.45	2.90e-03	2.52e-02	7/25	RBPJ; CITED2; ANXA1; ETS1; GATA3; ARID5B; MAPK1
GO:0001906	cell killing	3.40	8.59e-06	2.32e-04	16/58	SLAMF7; PTPRC; GNLY; IL7R; NCR3; HSP90AB1; RPL30; CTSC; PRF1; GAPDH; LAG3; GZMB; B2M; RAB27A; CORO1A; RPS19
GO:0032637	interleukin-8 production	3.36	6.65e-03	4.70e-02	6/22	PTPN22; CD58; CD2; PTPRC; F2R; ANXA1
GO:0002065	columnar/cuboidal epithelial cell differentiation	3.20	4.65e-03	3.50e-02	7/27	SLC4A7; RBPJ; LEF1; FAM65B; PRDM1; FGFR1; TYMS
GO:0006605	protein targeting	3.19	0.00e+00	0.00e+00	67/259	RPL22; RPL11; RPS8; RPL5; RPS27; RPS7; RPS27A; RPL31; RPL32; RPL15; RPL14; RPL29; RPL24; RPL35A; RPL9; RPL34; RPS3A; RPL37; RPS23; RPS14; RPL10A; FYN; RPS12; GSTK1; SLC25A6; RPL10; RPS20; RPL7; RPL30; RPS6; STOM; RPL7A; RPLP2; RPL27A; RPS13; RPS25; RPS24; RPL41; RPL6; UBC; RPL21; RPS29; SRP14; RAB27A; RPS27L; RPL4; RPLP1; RPS17; RPS15A; RPL13; RPL26; RPL23A; RPL23; RPL19; RPL27; RPL38; PRNP; RPS21; RPL36; RPS28; RPL18A; UBA52; RPS16; RPS19; RPL18; RPL13A; RPS11; RPS5
GO:0007229	integrin-mediated signaling pathway	3.17	1.45e-03	1.51e-02	9/35	FCER1G; PLEK; ITGA4; FYB; ITGA1; FLNA; TLN1; ITGB1; CD63
GO:0002576	platelet degranulation	3.16	4.61e-04	6.21e-03	11/43	FCER1G; PLEK; ANXA5; FLNA; TLN1; CTSW; SRGN; CD63; ACTN1; PECAM1; ACTN4
GO:0034341	response to interferon-gamma	3.12	1.59e-06	5.80e-05	21/83	CD58; TXK; HLA-DRA; HLA-DRB5; HLA-DRB1; HLA-DQA1; HLA-DQB1; HLA-DPA1; HLA-DPB1; HSP90AB1; CD44; CASP1; VIM; GAPDH; B2M; CCL5; CCL3; CCL3L3; CCL4L2; BST2; RPL13A
GO:0071887	leukocyte apoptotic process	3.08	3.22e-04	4.60e-03	12/48	FCER1G; SLC39A10; FOXP1; IL7R; CD74; RPS6; ANXA1; ADAM8; CD27; LGALS3; CCL5; CCR7
GO:0070371	ERK1 and ERK2 cascade	3.08	6.10e-06	1.85e-04	19/76	JUN; RAP1A; PTPN22; SLAMF1; PTPRC; PTGER4; F2R; CD74; FGFR1; MYC; GLIPR2; CD44; GPR183; CCL5; CCL3; CCL3L3; CCL4L2; CCR7; MAPK1
GO:0035821	modification of morphology or physiology of other organism	3.04	4.09e-05	8.52e-04	16/65	JUN; EIF2AK2; GNLY; LEF1; SLC25A6; RPL30; STOM; CFL1; PRF1; GAPDH; ANXA2; CCL5; CCL3; CCL4L2; TYMS; RPS19
GO:0050663	cytokine secretion	3.04	4.09e-05	8.52e-04	16/65	TNFRSF1B; PTPN22; CD58; CD2; SPTBN1; FOXP1; RBPJ; PTGER4; F2R; ANXA1; CASP1; GATA3; SRGN; GAPDH; CCL3; CCR7
GO:0002449	lymphocyte mediated immunity	3.02	3.08e-07	1.49e-05	25/102	TNFRSF1B; SLAMF7; FCER1G; DENND1B; PTPRC; CD55; CD8A; IL7R; CD74; NCR3; HLA-DQB1; MYO1G; CTSC; GATA3; PRF1; CD27; LAG3; KLRD1; KLRC2; GZMB; BATF; B2M; RAB27A; CORO1A; C1QBP
GO:0097485	neuron projection guidance	3.01	1.24e-03	1.33e-02	10/41	SPTBN1; CXCR4; RPL24; EMB; FYN; SH3KBP1; DOK2; GATA3; ARHGAP35; MAPK1
GO:0032612	interleukin-1 production	2.98	7.10e-03	4.92e-02	7/29	IFI16; FOXP1; F2R; ANXA1; CASP1; CCL3; CCR7
GO:0070555	response to interleukin-1	2.97	2.74e-04	3.99e-03	13/54	RPS27A; SQSTM1; ANXA1; ETS1; UBC; CYBA; CCL5; CCL3; CCL3L3; CCL4L2; AES; KLF2; UBA52
GO:0070661	leukocyte proliferation	2.91	6.77e-07	2.90e-05	25/106	TNFRSF1B; PTPN22; PTPRC; CD55; SLC39A10; SATB1; LEF1; IL7R; IL6ST; CD74; HLA-DMB; HLA-DPA1; HLA-DPB1; FYN; RPS6; ANXA1; CD81; ATM; GPR183; LGALS3; CORO1A; CCL5; IKZF3; PRNP; RASAL3
GO:0032609	interferon-gamma production	2.85	3.26e-03	2.73e-02	9/39	PTPN22; CD2; TXK; HLA-DPA1; HLA-DPB1; GATA3; C1QBP; CCR7; PRNP
GO:0043062	extracellular structure organization	2.81	4.84e-04	6.35e-03	13/57	TNFRSF1B; ITGA4; ITGA1; CD44; ETS1; ITGB1; ADAM8; LCP1; ANXA2; ICAM2; PECAM1; CST3; SPINT2
GO:0008037	cell recognition	2.78	3.91e-03	3.17e-02	9/40	EMB; NCR3; PRF1; CCT2; LGALS3; CORO1A; CCR7; PECAM1; ARHGAP35
GO:0050866	negative regulation of cell activation	2.77	5.79e-04	7.14e-03	13/58	PTPN22; CD84; PTPRC; ID2; TIGIT; CD74; FAM65B; ANXA1; ATM; LAG3; LGALS3; PRNP; SAMSN1
GO:0042110	T cell activation	2.73	1.10e-10	1.00e-08	46/208	TNFRSF1B; ZNF683; PTPN22; CD2; FCER1G; PTPRC; CD55; CD8A; SATB1; FOXP1; TIGIT; RHOH; LEF1; IL7R; PTGER4; IL6ST; CAMK4; TCF7; CD74; FAM65B; HLA-DMB; HLA-DPA1; HLA-DPB1; MB21D1; PRDM1; FYN; RPS6; ANXA1; JAML; GATA3; ADAM8; CD27; LAG3; TESPA1; LCP1; GPR183; LGALS3; BATF; B2M; RAB27A; CORO1A; CCL5; CCR7; PRNP; RASAL3; LGALS1
GO:0010959	regulation of metal ion transport	2.71	2.77e-05	6.10e-04	20/91	CD84; ATP2B4; F2R; FYN; FLNA; SARAF; STOM; AHNAK; CD63; LGALS3; B2M; ANXA2; CORO1A; CYBA; CCL5; CCL3; CCL4L2; PRNP; ACTN4; YWHAH
GO:0051702	interaction with symbiont	2.71	4.67e-03	3.50e-02	9/41	JUN; LEF1; STOM; CFL1; GAPDH; ANXA2; CCL5; CCL3; CCL4L2
GO:0002285	lymphocyte activation involved in immune response	2.69	1.24e-04	2.19e-03	17/78	ZNF683; FCER1G; PTPRC; FOXP1; LEF1; PTGER4; HLA-DMB; RPS6; ANXA1; GATA3; LCP1; GPR183; LGALS3; BATF; RAB27A; CORO1A; LGALS1
GO:0002250	adaptive immune response	2.61	2.58e-07	1.34e-05	32/151	TNFRSF1B; ZNF683; CD84; SLAMF1; SLAMF7; FCER1G; DENND1B; PTPRC; CD55; CD8A; TXK; LEF1; IL7R; IL6ST; CAMK4; CD74; HLA-DQB1; PRDM1; FYN; MYO1G; ANXA1; CTSC; GATA3; PRF1; CD27; GPR183; BATF; B2M; RAB27A; PRKCB; C1QBP; SAMSN1
GO:0050727	regulation of inflammatory response	2.61	2.09e-05	4.91e-04	22/104	TNFRSF1B; FCER1G; PTPRC; CD55; FOXP1; PTGER4; IL6ST; GPSM3; ANXA1; CD81; BIRC3; ATM; ETS1; GATA3; PDCD4; ADAM8; C1QBP; CCL5; CCL3; CCL3L3; CCR7; RPS19
GO:0045861	negative regulation of proteolysis	2.59	6.49e-06	1.89e-04	25/119	RPL11; IFI6; RPL5; IFI16; CD55; RPS7; LEF1; CAST; TNFAIP8; PTTG1; HSP90AB1; NGFRAP1; CD44; BIRC3; DNAJC1; CD27; GAPDH; HERPUD1; RPL23; PRNP; CST3; CST7; BST2; SPINT2; GLTSCR2
GO:0032103	positive regulation of response to external stimulus	2.58	1.36e-04	2.25e-03	18/86	FCER1G; PTGER4; IL6ST; CD74; FAM65B; GPSM3; FGFR1; ETS1; PDCD4; ADAM8; CYBA; C1QBP; CCL5; CCL3; CCL3L3; CCL4L2; CCR7; RPS19
GO:0090596	sensory organ morphogenesis	2.58	6.50e-03	4.64e-02	9/43	FAM65B; PRDM1; AHI1; INSIG1; FGFR1; GATA3; C12orf57; RPL38; MAPK1
GO:0048017	inositol lipid-mediated signaling	2.57	4.35e-03	3.37e-02	10/48	F2R; FYN; FGFR1; GATA3; C1QBP; CCL5; HCST; GLTSCR2; MAPK1; PIK3IP1
GO:0007159	leukocyte cell-cell adhesion	2.57	6.15e-07	2.80e-05	31/149	PTPN22; SELL; PTPRC; CD55; ITGA4; TIGIT; IL7R; IL6ST; CD74; FAM65B; HLA-DMB; HLA-DPA1; HLA-DPB1; FYN; ANXA1; CD44; ETS1; GATA3; ITGB1; ADAM8; CD27; LAG3; TESPA1; LGALS3; CORO1A; CCL5; CCR7; PECAM1; PRNP; RASAL3; LGALS1
GO:0050920	regulation of chemotaxis	2.56	2.92e-03	2.52e-02	11/53	CXCR4; CD74; FAM65B; GPSM3; FGFR1; GPR183; C1QBP; CCL5; CCL3; CCL4L2; CCR7
GO:0002521	leukocyte differentiation	2.55	6.53e-09	4.76e-07	42/203	ZNF683; JUN; PTPN22; CD2; IFI16; FCER1G; PTPRC; ID2; CD8A; ITGA4; SATB1; FOXP1; RBPJ; RHOH; LEF1; IL7R; PTGER4; CAMK4; TCF7; CD74; GLO1; PRDM1; MYC; RPS6; ANXA1; ATM; KLF6; GATA3; ITGB1; ADAM8; CD27; TESPA1; GPR183; LGALS3; BATF; GPR68; B2M; ANXA2; CCL3; IKZF3; CCR7; LGALS1
GO:0001819	positive regulation of cytokine production	2.54	2.19e-07	1.23e-05	34/165	PTPN22; CD58; CD2; IFI16; FCER1G; PTPRC; EIF2AK2; SPTBN1; TIGIT; TXK; HMGB2; PTGER4; IL6ST; F2R; CD74; LTB; GPSM3; HLA-DPA1; HLA-DPB1; MB21D1; AKIRIN2; ANXA1; BIRC3; CASP1; GATA3; DDX21; ADAM8; GAPDH; B2M; CYBA; C1QBP; CCL3; CCR7; GLTSCR2
GO:0033002	muscle cell proliferation	2.52	5.08e-03	3.74e-02	10/49	LDLRAP1; JUN; ID2; FOXP1; RBPJ; FGFR1; PDCD4; CYBA; CCL5; ERN1
GO:0060485	mesenchyme development	2.51	3.41e-03	2.82e-02	11/54	S100A4; ZEB2; RBPJ; LEF1; CITED2; FGFR1; MYC; GLIPR2; CFL1; PDCD4; MAPK1
GO:0022407	regulation of cell-cell adhesion	2.50	1.13e-06	4.57e-05	31/153	PTPN22; PTPRC; CD55; ITGA4; TIGIT; LEF1; IL7R; IL6ST; CD74; FAM65B; HLA-DMB; HLA-DPA1; HLA-DPB1; FYN; CITED2; ANXA1; CD44; ETS1; GATA3; ADAM8; CD27; LAG3; TESPA1; LGALS3; CORO1A; CCL5; CCR7; PRNP; RASAL3; SPINT2; LGALS1
GO:0002694	regulation of leukocyte activation	2.49	3.13e-08	2.07e-06	40/198	TNFRSF1B; ZNF683; PTPN22; CD2; CD84; FCER1G; PTPRC; CD55; ID2; SLC39A10; TIGIT; IL7R; IL6ST; CAMK4; CD74; FAM65B; HLA-DMB; HLA-DPA1; HLA-DPB1; MB21D1; PRDM1; FYN; ANXA1; CD81; ATM; GATA3; ADAM8; CD27; LAG3; TESPA1; GPR183; LGALS3; CORO1A; CCL5; IKZF3; CCR7; PRNP; RASAL3; LGALS1; SAMSN1
GO:0001818	negative regulation of cytokine production	2.44	1.32e-04	2.25e-03	20/101	PTPN22; CD84; SLAMF1; PTPRC; IKBKE; TRIB2; TIGIT; LEF1; PTGER4; HSP90AB1; FGFR1; ANXA1; GATA3; SRGN; PDCD4; LAG3; C1QBP; PRNP; KLF2; BST2
GO:0042113	B cell activation	2.42	1.03e-04	1.87e-03	21/107	PTPRC; ID2; ITGA4; SLC39A10; RBPJ; LEF1; IL7R; CD74; SKAP2; CD81; ATM; KLF6; ITGB1; CD27; GPR183; BATF; PRKCB; IKZF3; BST2; LGALS1; SAMSN1
GO:0006909	phagocytosis	2.41	3.33e-04	4.62e-03	18/92	RAP1A; SLAMF1; FCER1G; PTPRC; WIPF1; ARPC2; LYAR; GNB2L1; HSP90AB1; FYN; MYO1G; ANXA1; ITGB1; RAB27A; CORO1A; CYBA; PECAM1; MAPK1
GO:0098542	defense response to other organism	2.40	3.99e-06	1.38e-04	30/154	IFI6; IFI16; FCER1G; PTPRC; EIF2AK2; GNLY; FOXP1; RBPJ; PLAC8; HMGB2; SERINC5; MB21D1; FLNA; RPL30; BIRC3; DDX21; PRF1; DDIT4; GAPDH; BATF; ISG20; COTL1; CYBA; C1QBP; BST2; RPS19; GLTSCR2; APOBEC3C; APOBEC3G; APOBEC3H
GO:0031349	positive regulation of defense response	2.35	4.64e-06	1.54e-04	31/163	PTPN22; PYHIN1; IFI16; FCER1G; IKBKE; RPS27A; TXK; HMGB2; PTGER4; IL6ST; NCR3; GPSM3; MB21D1; FYN; SLC25A6; BIRC3; ETS1; PDCD4; ADAM8; LAG3; UBC; CYBA; C1QBP; CCL5; CCL3; CCL3L3; CCR7; ICAM2; UBA52; RPS19; GLTSCR2
GO:2000147	positive regulation of cell motility	2.34	1.02e-05	2.65e-04	29/153	JUN; RHOC; PTPRC; ITGA4; FOXP1; LEF1; F2R; CD74; GNB2L1; FAM65B; GPSM3; FLNA; FGFR1; GLIPR2; ANXA1; ATM; ETS1; GATA3; ADAM8; LGALS3; IQGAP1; CORO1A; C1QBP; CCL5; CCL3; CCL4L2; CCR7; ACTN4; MAPK1
GO:0034612	response to tumor necrosis factor	2.34	5.02e-04	6.41e-03	18/95	TNFRSF1B; CD58; GNB2L1; LTB; BIRC3; CASP1; GATA3; CD27; YBX3; CYBA; CCL5; CCL3; CCL3L3; CCL4L2; CD70; KLF2; ACTN4; MAPK1
GO:0050867	positive regulation of cell activation	2.34	4.26e-05	8.62e-04	25/132	CD2; FCER1G; PTPRC; CD55; PLEK; SLC39A10; IL7R; IL6ST; CD74; HLA-DMB; HLA-DPA1; HLA-DPB1; FYN; ANXA1; CD81; GATA3; ADAM8; CD27; TESPA1; GPR183; CORO1A; CCL5; CCR7; RASAL3; LGALS1
GO:0045785	positive regulation of cell adhesion	2.32	1.72e-05	4.31e-04	28/149	PTPRC; CD55; ITGA4; ARPC2; IL7R; IL6ST; CD74; HLA-DMB; HLA-DPA1; HLA-DPB1; FYN; CITED2; FLNA; ANXA1; CD44; ATM; ETS1; GATA3; ADAM8; CD27; TESPA1; IQGAP1; CORO1A; C1QBP; CCL5; CCR7; RASAL3; LGALS1
GO:0002440	production of molecular mediator of immune response	2.31	1.62e-03	1.64e-02	15/80	TNFRSF1B; FCER1G; DENND1B; PTPRC; CD55; IL7R; CAMK4; CD74; HLA-DQB1; MB21D1; GATA3; DDX21; BATF; B2M; BST2
GO:0072507	divalent inorganic cation homeostasis	2.27	1.37e-04	2.25e-03	23/125	PTPRC; ATP2B4; CD55; CXCR4; SLC39A10; CXCR6; CCDC109B; ANXA5; PTGER4; F2R; FYN; TPT1; LPAR6; ANXA2; PRKCB; CORO1A; HERPUD1; CYBA; EIF5A; CCL5; CCL3; CCR7; PRNP
GO:0002791	regulation of peptide secretion	2.27	7.15e-05	1.37e-03	25/136	TNFRSF1B; RAP1A; PTPN22; CD58; CD2; SPTBN1; PASK; FOXP1; ANXA5; PTGER4; F2R; CD74; SLC25A6; SLC25A5; ANXA1; CASP1; GATA3; DNAJC1; SRGN; ADAM8; GAPDH; GPR68; CCL5; CCL3; CCR7
GO:0019882	antigen processing and presentation	2.26	1.09e-03	1.19e-02	17/93	FCER1G; CD8A; CD74; HLA-DRA; HLA-DRB5; HLA-DRB1; HLA-DQA1; HLA-DQB1; HLA-DMB; HLA-DPA1; HLA-DPB1; CTSD; LAG3; B2M; RAB27A; CCR7; AP1M1
GO:0009615	response to virus	2.24	4.78e-05	9.40e-04	27/149	IFI6; IFI16; PTPRC; IKBKE; EIF2AK2; CXCR4; SERINC5; MB21D1; FLNA; CFL1; BIRC3; GATA3; DDX21; PRF1; DDIT4; TPT1; NPC2; ISG20; RPS15A; C1QBP; CCL5; CCL4L2; BST2; GLTSCR2; APOBEC3C; APOBEC3G; APOBEC3H
GO:0072511	divalent inorganic cation transport	2.23	3.36e-04	4.62e-03	21/116	CD84; PTPRC; ATP2B4; SLC39A10; CCDC109B; ANXA5; F2R; FYN; SARAF; AHNAK; TPT1; LGALS3; ANXA2; PRKCB; CORO1A; CYBA; CCL5; CCL3; CCL4L2; CCR7; PRNP
GO:0030099	myeloid cell differentiation	2.20	1.86e-05	4.51e-04	31/174	JUN; IFI16; FCER1G; ID2; SNRK; FOXP1; GPR171; LYAR; RBPJ; LEF1; HMGB2; CAMK4; CD74; RPS14; GLO1; MYC; RPS6; ETS1; GATA3; GPR183; LGALS3; ACTN1; BATF; GPR68; B2M; ANXA2; PRKCB; CCL3; CCR7; KLF2; RPS19
GO:0031589	cell-substrate adhesion	2.17	2.31e-03	2.17e-02	16/91	ITGA4; ARPC2; ITGA1; MYO1G; FLNA; CD44; ITGB1; CD63; ACTN1; IQGAP1; CORO1A; C1QBP; CCR7; PECAM1; ACTN4; LGALS1
GO:0002237	response to molecule of bacterial origin	2.16	1.77e-03	1.72e-02	17/97	TNFRSF1B; JUN; PTPN22; CD55; FOXP1; HMGB2; PTGER4; F2R; AKIRIN2; CASP1; VIM; PDCD4; B2M; CCL5; CCL3; CCR7; MAPK1
GO:0002764	immune response-regulating signaling pathway	2.12	4.96e-06	1.57e-04	38/221	JUN; RAP1A; PTPN22; FCER1G; DENND1B; PTPRC; IKBKE; RPS27A; WIPF1; SLC39A10; ARPC2; TXK; FYB; NCR3; HLA-DRA; HLA-DRB5; HLA-DRB1; HLA-DQA1; HLA-DQB1; HLA-DPA1; HLA-DPB1; HSP90AB1; FYN; MYO1G; BIRC3; GATA3; TESPA1; UBC; LGALS3; PRKCB; CYBA; C1QBP; CCR7; ICAM2; PRNP; UBA52; GLTSCR2; MAPK1
GO:0061564	axon development	2.11	1.70e-03	1.67e-02	18/105	JUN; S100A6; SPTBN1; CXCR4; ZEB2; ITGA4; RPL24; SKIL; EMB; HSP90AB1; FYN; SH3KBP1; DOK2; GATA3; ITGB1; C12orf57; ARHGAP35; MAPK1
GO:0007162	negative regulation of cell adhesion	2.11	5.60e-03	4.03e-02	14/82	PTPN22; PTPRC; TIGIT; CD74; FAM65B; ANXA1; PDE3B; LAG3; ARHGDIB; LGALS3; PRNP; SPINT2; ACTN4; LGALS1
GO:0048732	gland development	2.11	7.60e-04	8.64e-03	21/123	JUN; LMO4; RAP1A; ID2; LBH; RBPJ; LEF1; CITED2; FGFR1; ANXA1; ETS1; GATA3; ARID5B; CRIP1; PKM; APRT; RPL19; TYMS; RPS16; ARHGAP35; MAPK1
GO:0048872	homeostasis of number of cells	2.11	7.60e-04	8.64e-03	21/123	FCER1G; ID2; SKIL; LYAR; HMGB2; IL7R; F2R; CD74; RPS14; RPS6; ANXA1; ETS1; GATA3; RPS24; GPR183; B2M; RPS17; CORO1A; CCR7; KLF2; RPS19
GO:0002697	regulation of immune effector process	2.10	2.60e-04	3.86e-03	25/147	TNFRSF1B; ZNF683; RAP1A; CD84; FCER1G; PTPRC; CD55; IL7R; CD74; NCR3; HLA-DMB; MB21D1; ANXA1; CD81; BIRC3; GATA3; DDX21; LAG3; LGALS3; B2M; C1QBP; BST2; RPS19; GLTSCR2; APOBEC3G
GO:0043900	regulation of multi-organism process	2.08	9.87e-05	1.84e-03	29/172	JUN; IFI16; CD55; EIF2AK2; FOXP1; LEF1; CD74; SQSTM1; MB21D1; PABPC1; STOM; CFL1; BIRC3; PRF1; GAPDH; ARHGDIB; ANXA2; ISG20; CYBA; C1QBP; CCL5; CCL3; CCL4L2; BST2; GLTSCR2; LGALS1; APOBEC3C; APOBEC3G; APOBEC3H
GO:0001503	ossification	2.08	4.76e-03	3.54e-02	15/89	DHRS3; ID2; RBPJ; LEF1; PTGER4; IL6ST; CLIC1; OSTF1; DDX21; SRGN; RSL1D1; CCL3; RPL38; TPM4; MAPK1
GO:0007015	actin filament organization	2.07	7.22e-04	8.47e-03	22/131	RHOC; CDC42EP3; SPTBN1; PLEK; TMSB10; WIPF1; ARPC2; RHOH; PTGER4; IQGAP2; ARHGAP18; FLNA; CFL1; ITGB1; LIMA1; LCP1; ACTN1; CORO1A; CCR7; TPM4; ACTN4; ARHGAP35
GO:0036230	granulocyte activation	2.07	1.24e-06	4.76e-05	45/268	TNFRSF1B; RAP1A; CD58; S100A11; FCER1G; SELL; PTPRC; CD55; GYG1; PLAC8; IQGAP2; HSP90AB1; EEF1A1; PTPRN2; OSTF1; STOM; CTSD; CD44; FTH1; CTSC; ADAM8; CD63; CCT2; GLIPR1; LGALS3; NPC2; SRP14; B2M; RAB27A; ANXA2; PKM; IQGAP1; COTL1; CYBA; APRT; CCL5; CCL3; PECAM1; CST3; CTSA; EEF2; AP1M1; BST2; FTL; MAPK1
GO:1903706	regulation of hemopoiesis	2.06	1.60e-04	2.53e-03	28/168	ZNF683; JUN; CD2; PTPRC; ID2; EIF2AK2; FOXP1; GPR171; LEF1; HMGB2; IL7R; CAMK4; CD74; PRDM1; MYC; ANXA1; ETS1; GATA3; ADAM8; CD27; TESPA1; LGALS3; GPR68; B2M; PRKCB; CCL3; IKZF3; LGALS1
GO:0051346	negative regulation of hydrolase activity	2.04	5.21e-04	6.53e-03	24/145	IFI6; IFI16; RHOH; LEF1; GZMA; IQGAP2; CAST; TNFAIP8; PTTG1; PTPRN2; NGFRAP1; ANXA1; CD44; SYTL2; BIRC3; CD27; GAPDH; LGALS3; IQGAP1; HERPUD1; CST3; CST7; BST2; SPINT2
GO:0002009	morphogenesis of an epithelium	2.02	3.80e-03	3.11e-02	17/104	LMO4; RHOC; RPS7; ZEB2; FOXP1; RBPJ; LEF1; AHI1; FLNA; FGFR1; MYC; CD44; CFL1; GATA3; LCP1; SPINT2; ARHGAP35
GO:0052547	regulation of peptidase activity	2.02	4.89e-04	6.35e-03	25/153	IFI6; IFI16; LEF1; F2R; CAST; TNFAIP8; PTTG1; GNB2L1; AKIRIN2; FYN; PERP; NGFRAP1; MYC; CD44; BIRC3; CASP1; CD27; GAPDH; IFI27L2; RPS27L; HERPUD1; CST3; CST7; BST2; SPINT2

Factor 2 : 45 significant GO terms

GeneSet	description	enrichRatio	pValue	FDR	GeneRatio	geneSymbols
GO:0070972	protein localization to endoplasmic reticulum	7.86	0.00e+00	0.00e+00	59/122	RPL11; RPS8; RPL5; RPS27; SRP9; RPS7; RPS27A; RPL31; RPL32; RPL15; RPL14; RPL29; RPL24; RPL35A; RPL9; RPL34; RPS3A; RPL37; RPS23; RPS14; RPS18; RPS10; RPS12; RPS4X; RPL39; RPL10; RPS20; RPL7; RPL30; RPL12; RPL7A; RPLP2; RPL27A; RPS13; RPS3; RPS25; RPL21; RPS29; RPLP1; RPS15A; RPL13; RPL26; RPL23A; RPL23; RPL19; RPL27; RPL38; RPS15; RPL36; RPS28; UBA52; RPS16; RPS19; RPL18; RPL13A; RPS11; RPL28; RPS5; RPL3
GO:0050918	positive chemotaxis	6.77	4.73e-04	1.01e-02	5/12	HMGB2; HMGB1; CORO1A; CCL5; MIF
GO:0051383	kinetochore organization	6.77	4.73e-04	1.01e-02	5/12	CENPF; SMC4; SMC2; STRA13; NDC80
GO:0006413	translational initiation	6.30	0.00e+00	0.00e+00	62/160	RPL11; RPS8; RPL5; RPS27; RPS7; RPS27A; RPL31; RPL32; RPL15; RPL14; RPL29; RPL24; RPL35A; RPL9; RPL34; RPS3A; RPL37; RPS23; RPS14; RPS18; RPS10; RPS12; EIF1AX; RPS4X; RPL39; RPL10; RPS20; RPL7; RPL30; EIF3E; RPL12; RPL7A; RPLP2; RPL27A; RPS13; RPS3; RPS25; RPL21; RPS29; RPLP1; RPS15A; RPL13; RPL26; RPL23A; CCL5; RPL23; RPL19; EIF1; RPL27; RPL38; RPS15; RPL36; RPS28; UBA52; RPS16; RPS19; RPL18; RPL13A; RPS11; RPL28; RPS5; RPL3
GO:0051131	chaperone-mediated protein complex assembly	5.91	3.29e-03	4.64e-02	4/11	HSPD1; HSP90AB1; PTGES3; HSP90AA1
GO:0090150	establishment of protein localization to membrane	5.23	0.00e+00	0.00e+00	66/205	RPL11; RPS8; RPL5; RPS27; SRP9; RPS7; YWHAQ; RPS27A; RPL31; RPL32; RPL15; RPL14; RPL29; RPL24; RPL35A; RPL9; RPL34; RPS3A; RPL37; RPS23; RPS14; GNB2L1; RPS18; RPS10; RPS12; RPS4X; RPL39; RPL10; RPS20; RPL7; RPL30; RPL12; RPL7A; RPLP2; RPL27A; RPS13; RPS3; RPS25; RPL21; TFDP1; RPS29; CALM1; HSP90AA1; RPLP1; RPS15A; RPL13; YWHAE; RPL26; RPL23A; RPL23; RPL19; RPL27; RPL38; RPS15; RPL36; RPS28; UBA52; RPS16; RPS19; RPL18; RPL13A; RPS11; RPL28; RPS5; YWHAH; RPL3
GO:0002181	cytoplasmic translation	5.03	8.67e-11	1.05e-08	22/71	RPL11; RPL31; RPL32; RPL15; RPL29; RPL24; RPL35A; RPL9; RPS23; RPL39; RPL30; EIF3E; RPS29; RPLP1; RPL26; RPL19; RPL38; EEF2; RPL36; RPS28; RPL18; RPL13A
GO:0070671	response to interleukin-12	4.64	3.11e-05	1.33e-03	10/35	HNRNPDL; LMNB1; HNRNPA2B1; PPIA; CFL1; LCP1; PSME2; ANXA2; SNRPA1; MIF
GO:0042769	DNA damage response, detection of DNA damage	4.64	1.97e-04	5.98e-03	8/28	USP1; RPS27A; RPA3; POLD2; RFC2; RPS3; PCNA; UBA52
GO:0006401	RNA catabolic process	4.55	0.00e+00	0.00e+00	70/250	HNRNPR; RPL11; YBX1; RPS8; RPL5; RPS27; RPS7; RPS27A; RPL31; RPL32; LSM3; RPL15; RPL14; RPL29; RPL24; RPL35A; RPL9; HNRNPD; RPL34; RPS3A; RPL37; RPS23; RPS14; RPS18; RPS10; RPS12; LSM5; RPS4X; RPL39; RPL10; RPS20; RPL7; RPL30; EIF3E; RPL12; SET; RPL7A; RPLP2; RPL27A; RPS13; RPS3; RPS25; HSPA8; MAGOHB; RPL21; RPS29; RPLP1; RPS15A; RPL13; RPL26; RPL23A; RPL23; RPL19; RPL27; RPL38; EIF4A3; RPS15; RPL36; RPS28; HNRNPM; LSM4; UBA52; RPS16; RPS19; RPL18; RPL13A; RPS11; RPL28; RPS5; RPL3
GO:0036297	interstrand cross-link repair	4.43	1.66e-03	2.75e-02	6/22	NUCKS1; MSH6; RPS27A; RPA3; STRA13; UBA52
GO:0009262	deoxyribonucleotide metabolic process	4.24	2.14e-03	3.24e-02	6/23	DTYMK; NUDT1; RRM1; DUT; DCTPP1; TYMS
GO:0031099	regeneration	3.98	2.79e-05	1.27e-03	12/49	DHFR; EZH2; GSTP1; CDK4; LCP1; PKM; RPL19; PHB; TYMS; PCNA; RPS16; MT-CYB
GO:0006605	protein targeting	3.95	0.00e+00	0.00e+00	63/259	RPL11; RPS8; RPL5; RPS27; SRP9; RPS7; RPS27A; RPL31; HSPD1; RPL32; RPL15; RPL14; RPL29; RPL24; RPL35A; RPL9; RPL34; RPS3A; RPL37; RPS23; RPS14; RPS18; RPS10; RPS12; TOMM7; RPS4X; RPL39; RPL10; RPS20; RPL7; RPL30; RPL12; RPL7A; RPLP2; RPL27A; RPS13; RPS3; RPS25; HSPA8; RPL21; RPS29; HSP90AA1; RPLP1; RPS15A; RPL13; RPL26; RPL23A; RPL23; RPL19; RPL27; RPL38; RPS15; RPL36; RPS28; UBA52; RPS16; RPS19; RPL18; RPL13A; RPS11; RPL28; RPS5; RPL3
GO:0048857	neural nucleus development	3.90	3.38e-03	4.64e-02	6/25	YWHAQ; ACTB; CALM1; YWHAE; YWHAH; ATP5J
GO:0006333	chromatin assembly or disassembly	3.48	1.60e-05	8.32e-04	15/70	NASP; H3F3A; HMGB2; H2AFY; HIST1H1C; HIST1H1E; HIST1H1D; HIST1H1B; ANP32B; SET; HELLS; HMGB1; SUPT16H; STRA13; CENPM
GO:0006959	humoral immune response	3.45	3.32e-03	4.64e-02	7/33	HMGN2; HLA-E; RPL39; RPL30; CD59; PHB; RPS19
GO:0030901	midbrain development	3.45	3.32e-03	4.64e-02	7/33	YWHAQ; UQCRQ; ACTB; CALM1; YWHAE; YWHAH; ATP5J
GO:0032355	response to estradiol	3.42	1.81e-03	2.86e-02	8/38	HNRNPD; H2AFZ; ARPC1B; EZH2; GSTP1; PCNA; EEF2; CALR
GO:0071897	DNA biosynthetic process	3.19	2.67e-06	2.28e-04	20/102	CENPF; RPS27A; HNRNPD; CCT5; NHP2; HSP90AB1; RPA3; HNRNPA2B1; POLD2; PPIA; RFC2; HNRNPA1; PTGES3; TFDP1; HSP90AA1; KIAA0101; PHB; TYMS; PCNA; UBA52
GO:0051702	interaction with symbiont	3.17	3.01e-03	4.47e-02	8/41	NUCKS1; HSPD1; PSMC3; CFL1; HSPA8; CALM1; ANXA2; CCL5
GO:0001906	cell killing	3.08	6.72e-04	1.32e-02	11/58	HMGN2; PRDX1; IL7R; HLA-E; TUBB; HSP90AB1; HPRT1; RPL30; TUBB4B; CORO1A; RPS19
GO:1902600	proton transmembrane transport	3.03	1.52e-04	4.90e-03	14/75	ATP5G3; COX17; ATP5J2; TMSB4X; COX7B; STOML2; COX8A; COX6A1; ATP5G1; ATP5J; MT-CO1; MT-ATP6; MT-CO3; MT-CYB
GO:0071103	DNA conformation change	3.01	6.71e-06	4.07e-04	20/108	NASP; H3F3A; SMC4; HMGB2; H2AFY; HIST1H1C; HIST1H1E; HIST1H1D; HIST1H1B; HNRNPA2B1; MCM7; ANP32B; SMC2; SET; HELLS; HMGB1; NUSAP1; TOP2A; STRA13; CENPM
GO:0035821	modification of morphology or physiology of other organism	3.00	4.99e-04	1.01e-02	12/65	HMGN2; NUCKS1; RPL30; PSMC3; CFL1; HSPA8; CALM1; ANXA2; CCL5; KPNA2; TYMS; RPS19
GO:0051321	meiotic cell cycle	3.00	4.99e-04	1.01e-02	12/65	ASPM; MSH6; ACTR3; SMC4; PTTG1; SMC1A; RAD21; CKS2; SMC2; TOP2A; STRA13; CALR
GO:0009141	nucleoside triphosphate metabolic process	2.87	2.05e-08	2.13e-06	33/187	ENO1; NDUFS5; ATP5G3; DTYMK; NDUFS6; UQCRQ; UQCC2; NUDT1; CYCS; ATP5J2; NDUFB2; TMSB4X; PGK1; UQCRB; STOML2; LDHA; HSPA8; PGAM1; TPI1; COX6A1; RAN; DUT; PKM; DCTPP1; ATP5G1; NME1; TYMS; ATP5J; MT-ND2; MT-CO1; MT-ATP6; MT-CO3; MT-CYB
GO:0071824	protein-DNA complex subunit organization	2.77	5.95e-06	3.94e-04	23/135	NASP; ANP32E; CENPF; H3F3A; RPS27A; PTMA; HMGB2; H2AFY; HIST1H1C; HIST1H1E; HIST1H1D; HIST1H1B; RPA3; ANP32B; SET; PSMC3; HELLS; HMGB1; SUPT16H; RPL23; STRA13; UBA52; CENPM
GO:0006260	DNA replication	2.68	6.08e-05	2.33e-03	19/115	NASP; NUCKS1; MSH6; SLBP; MCM3; RPA3; POLD2; RFC2; MCM7; SMC1A; STOML2; SET; RRM1; SSRP1; SUPT16H; DUT; KIAA0101; STRA13; PCNA
GO:0034341	response to interferon-gamma	2.54	1.49e-03	2.64e-02	13/83	ACTR3; HLA-E; HLA-DRA; HLA-DRB5; HLA-DRB1; HLA-DPA1; HSP90AB1; CD44; EVL; MT2A; CCL5; ACTG1; RPL13A
GO:0032200	telomere organization	2.51	1.66e-03	2.75e-02	13/84	H3F3A; HNRNPD; CCT5; NHP2; HSP90AB1; RPA3; HNRNPA2B1; POLD2; RFC2; HNRNPA1; PTGES3; HSP90AA1; PCNA
GO:0006310	DNA recombination	2.51	1.55e-04	4.90e-03	19/123	SFPQ; NUCKS1; MSH6; HSPD1; ACTL6A; TFRC; WHSC1; HMGB2; IL7R; HIST1H1C; HIST1H1E; HIST1H1D; HIST1H1B; RPA3; RAD21; HMGB1; TOP2A; KPNA2; STRA13
GO:0071826	ribonucleoprotein complex subunit organization	2.48	3.59e-06	2.61e-04	29/190	RPL11; SRSF10; RPL5; RPS27; SNRPE; SNRPG; LSM3; RPL24; RPS23; RPS14; RPS10; HSP90AB1; RPL10; EIF3E; RPL12; PTGES3; HSP90AA1; RPL23A; RPL38; SNRPD1; SNRPB; RPS15; RPS28; LSM4; RPS19; GLTSCR2; RPL13A; RPS5; RPL3
GO:0009123	nucleoside monophosphate metabolic process	2.46	2.82e-06	2.28e-04	30/198	ENO1; NDUFS5; ATP5G3; DTYMK; NDUFS6; UQCRQ; UQCC2; CYCS; ATP5J2; NDUFB2; TMSB4X; PGK1; HPRT1; UQCRB; STOML2; LDHA; HSPA8; PGAM1; TPI1; COX6A1; DUT; PKM; ATP5G1; TYMS; ATP5J; MT-ND2; MT-CO1; MT-ATP6; MT-CO3; MT-CYB
GO:0009636	response to toxic substance	2.45	2.20e-05	1.07e-03	25/166	PRDX1; HSPD1; DHFR; GNB2L1; ACTB; EZH2; HPRT1; TXN; LDHA; GSTP1; RPS3; HNRNPA1; CDK4; CALM1; MT2A; MT1E; TXNDC17; CCL5; PHB; TYMS; PCNA; EEF2; PRDX2; UBA52; MT-CYB
GO:0045787	positive regulation of cell cycle	2.35	9.01e-05	3.12e-03	23/159	SFPQ; CKS1B; MAD2L1; H2AFY; HSP90AB1; EZH2; RAD21; CKS2; KIF20B; CDK4; TFDP1; NUSAP1; RPS15A; RPL26; EVI2B; RPL23; ANAPC11; NDC80; PCNA; UBE2C; CALR; RAD23A; MIF
GO:0048285	organelle fission	2.33	3.52e-05	1.42e-03	26/181	ASPM; CENPF; ACTR3; RPL24; SMC4; MAD2L1; H2AFY; PTTG1; SMC1A; FLNA; RAD21; CKS2; SMC2; KIF20B; MKI67; RAN; NUSAP1; KIF22; TOP2A; ANAPC11; STRA13; NDC80; TPX2; UBE2C; CALR; UBE2S
GO:0007059	chromosome segregation	2.32	2.19e-04	6.37e-03	21/147	SFPQ; CENPF; ACTR3; SMC4; MAD2L1; H2AFY; PTTG1; SMC1A; SLC25A5; RAD21; SMC2; RPS3; MKI67; RAN; NUSAP1; KIF22; TOP2A; SKA2; ANAPC11; STRA13; NDC80
GO:0010948	negative regulation of cell cycle process	2.29	3.74e-04	9.08e-03	20/142	CENPF; MSH6; MAD2L1; H2AFY; PTTG1; HSP90AB1; EZH2; SMC1A; RAD21; CBX5; CDK4; TFDP1; RPL26; EVI2B; RPL23; NDC80; PCNA; CALR; GLTSCR2; MIF
GO:0046677	response to antibiotic	2.26	1.16e-03	2.16e-02	17/122	HSPD1; HNRNPD; GNB2L1; EZH2; TXN; LDHA; GSTP1; RPS3; FDX1; HNRNPA1; HSP90AA1; RPL23; PHB; TYMS; PCNA; EEF2; MT-CYB
GO:1901293	nucleoside phosphate biosynthetic process	2.24	3.50e-04	8.80e-03	21/152	ENO1; ATP5G3; DTYMK; ATP5J2; TMSB4X; PGK1; HPRT1; STOML2; RRM1; LDHA; PGAM1; TPI1; ERH; DUT; PKM; IDH2; ATP5G1; NME1; TYMS; ATP5J; MT-ATP6
GO:0051052	regulation of DNA metabolic process	2.17	9.00e-05	3.12e-03	27/202	USP1; NUCKS1; MSH6; TFRC; WHSC1; HNRNPD; CCT5; IL7R; DEK; HIST1H1C; HIST1H1E; HIST1H1D; HIST1H1B; HSP90AB1; HNRNPA2B1; RFC2; SMC1A; STOML2; RPS3; HNRNPA1; PTGES3; HMGB1; TFDP1; HSP90AA1; KPNA2; PCNA; DNMT1
GO:0016072	rRNA metabolic process	2.11	4.57e-04	1.01e-02	23/177	RPL11; EBNA1BP2; RPS8; RPL5; RPS27; RPS7; NCL; RPL14; RPL35A; H2AFY; RPS14; NHP2; GTF3C6; RPL7; RPL7A; RPL26; RPL27; EIF4A3; RPS15; RPS28; RPS16; RPS19; GLTSCR2
GO:0031647	regulation of protein stability	2.10	1.96e-03	3.04e-02	18/139	RPL11; RPL5; RPS7; HSPD1; CCT5; HIST1H1B; HSP90AB1; TOMM7; FLNA; HSPA8; PTGES3; HSP90AA1; PFN1; RPL23; PHB; CALR; RAD23A; GLTSCR2
GO:0010639	negative regulation of organelle organization	2.07	8.18e-04	1.57e-02	22/173	STMN1; CENPF; H3F3A; TMSB10; MAD2L1; H2AFY; PTTG1; HIST1H1C; HIST1H1E; HIST1H1D; HIST1H1B; TMSB4X; SLC25A5; RAD21; ATAD2; SET; HNRNPA1; CORO1A; PFN1; TOP2A; NDC80; DNMT1

Factor 3 : 91 significant GO terms

GeneSet	description	enrichRatio	pValue	FDR	GeneRatio	geneSymbols
GO:0050918	positive chemotaxis	6.39	6.16e-04	8.16e-03	5/12	S1PR1; LGALS3; IL16; CORO1A; CCL5
GO:0032613	interleukin-10 production	5.75	3.35e-04	5.19e-03	6/16	FCER1G; TRIB2; CD47; C10orf54; PYCARD; LGALS9
GO:0007229	integrin-mediated signaling pathway	5.70	1.20e-07	9.72e-06	13/35	FCER1G; ITGA6; ITGA4; CD47; ITGA1; TIMP1; FLNA; TSPAN32; ITGB1; ITGB7; LAT; ITGAL; ITGAE
GO:0032963	collagen metabolic process	5.65	1.19e-04	2.48e-03	7/19	MYB; VIM; ITGB1; C10orf54; RGCC; HIF1A; ARRB2
GO:0034113	heterotypic cell-cell adhesion	5.42	4.89e-04	6.85e-03	6/17	CD2; ITGA4; CD47; CD44; ITGB1; ITGB7
GO:1990868	response to chemokine	5.42	4.89e-04	6.85e-03	6/17	CXCR4; FAM65B; HIF1A; CIB1; CCL5; CCR7
GO:0060191	regulation of lipase activity	5.12	6.94e-04	9.02e-03	6/18	RHOC; FGFR1; ANXA1; GNAQ; CCL5; S1PR4
GO:0043062	extracellular structure organization	4.85	8.46e-09	1.23e-06	18/57	CYP1B1; CAPG; ITGA6; ITGA4; CD47; ITGA1; TIMP1; CSGALNACT1; CD44; ITGB1; NFKB2; ITGB7; RGCC; ANXA2; ITGAL; ITGAE; ICAM2; SPINT2
GO:0034109	homotypic cell-cell adhesion	4.60	7.99e-05	1.82e-03	9/30	RAP2B; CLIC1; HSPB1; FLNA; TSPAN32; VCL; CCL5; MYL12A; LGALS1
GO:0009581	detection of external stimulus	4.51	3.67e-03	2.94e-02	5/17	TTN; GNAQ; CALM1; ARRB2; UNC119
GO:0009582	detection of abiotic stimulus	4.51	3.67e-03	2.94e-02	5/17	TTN; GNAQ; CALM1; ARRB2; UNC119
GO:0060326	cell chemotaxis	4.50	8.68e-10	1.60e-07	22/75	S1PR1; FCER1G; LYST; CXCR4; ITGA1; CD74; FAM65B; AIF1; GPSM3; HSPB1; TMSB4X; FGFR1; ANXA1; BIN2; GPR183; LGALS3; IL16; CORO1A; ARRB2; LGALS9; CCL5; CCR7
GO:0032637	interleukin-8 production	4.19	2.23e-03	2.03e-02	6/22	PARK7; CD2; TMSB4X; ANXA1; PYCARD; LGALS9
GO:0007187	G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger	4.13	1.04e-03	1.19e-02	7/26	S1PR1; RGS1; FLNA; ANXA1; GNAQ; PTGER2; S1PR4
GO:0030048	actin filament-based movement	4.13	1.04e-03	1.19e-02	7/26	BIN1; TTN; FLNA; VIM; MYL6B; SYNE2; SUN2
GO:0050920	regulation of chemotaxis	4.05	4.42e-06	1.89e-04	14/53	S1PR1; CXCR4; CD74; FAM65B; AIF1; GPSM3; HSPB1; TMSB4X; FGFR1; GPR183; IL16; LGALS9; CCL5; CCR7
GO:0032615	interleukin-12 production	4.04	6.19e-03	4.34e-02	5/19	CD47; LTB; ARRB2; LGALS9; CCR7
GO:2001057	reactive nitrogen species metabolic process	4.00	2.86e-03	2.45e-02	6/23	CYP1B1; CD47; AIF1; GCHFR; KLF2; TSPO
GO:0050900	leukocyte migration	3.93	1.34e-11	9.74e-09	31/121	S1PR1; CD2; FCER1G; LYST; CXCR4; ITGA6; ITGA4; CD47; ITGA1; CD74; FAM65B; AIF1; GPSM3; MSN; DOK2; ANXA1; CD44; ITGB1; ITGB7; SELPLG; GPR183; LGALS3; IL16; CORO1A; ITGAL; PYCARD; GLG1; LGALS9; CCL5; CCR7; SIRPG
GO:0031032	actomyosin structure organization	3.84	3.94e-05	1.06e-03	12/48	STMN1; EPB41; S1PR1; RHOC; S100A10; TTN; CD47; ITGB1; PXN; RGCC; PFN1; CNN2
GO:0002526	acute inflammatory response	3.84	1.68e-03	1.67e-02	7/28	PARK7; FCER1G; CD55; IL6ST; HLA-E; CD59; CCR7
GO:0032103	positive regulation of response to external stimulus	3.75	7.63e-08	6.95e-06	21/86	PARK7; S1PR1; FCER1G; CD47; IL6ST; CD74; FAM65B; HLA-E; AIF1; GPSM3; HSPB1; TMSB4X; FGFR1; OPTN; NFKBIA; IL16; TRADD; CYBA; LGALS9; CCL5; CCR7
GO:0006959	humoral immune response	3.72	9.81e-04	1.19e-02	8/33	CD55; HLA-E; SH2D1A; CD59; GAPDH; RGCC; GPR183; CCR7
GO:1901654	response to ketone	3.70	1.38e-05	4.58e-04	14/58	PARK7; TXNIP; NR3C1; AKR1B1; MSN; DDIT4; ATP2B1; PEBP1; PTGER2; CALM1; CYBA; CCR7; KLF2; TSPO
GO:0002576	platelet degranulation	3.57	3.33e-04	5.19e-03	10/43	FCER1G; TTN; ANXA5; TMSB4X; TIMP1; FLNA; CTSW; SRGN; VCL; CALM1
GO:0071887	leukocyte apoptotic process	3.52	1.93e-04	3.61e-03	11/48	FCER1G; SLC39A10; IL7R; CD74; TSC22D3; ANXA1; LGALS3; HIF1A; LGALS9; CCL5; CCR7
GO:0070555	response to interleukin-1	3.41	1.36e-04	2.75e-03	12/54	TANK; CD47; SQSTM1; ANXA1; NFKBIA; HIF1A; PYCARD; CYBA; LGALS9; CCL5; AES; KLF2
GO:0007159	leukocyte cell-cell adhesion	3.30	8.78e-10	1.60e-07	32/149	TNFAIP8L2; CD55; ITGA4; CD47; IL7R; IL6ST; CD74; FAM65B; HLA-E; AIF1; HLA-DPB1; NT5E; MYB; MAD1L1; MSN; PAG1; ANXA1; CD44; ITGB1; C10orf54; ITGB7; SELPLG; LGALS3; CORO1A; ITGAL; PYCARD; LGALS9; CCL5; CCR7; SIRPG; TMIGD2; LGALS1
GO:0008277	regulation of G protein-coupled receptor signaling pathway	3.26	4.57e-03	3.36e-02	7/33	STMN1; RGS1; GRK6; RGS10; CALM1; ARRB2; CCL5
GO:0001906	cell killing	3.17	2.79e-04	4.73e-03	12/58	SLAMF7; LYST; IL7R; HLA-E; SH2D1A; PRF1; GAPDH; B2M; CORO1A; ARRB2; LGALS9; CD226
GO:0032609	interferon-gamma production	3.15	3.09e-03	2.58e-02	8/39	CD2; CD47; HLA-DPB1; C10orf54; PYCARD; LGALS9; CCR7; CD226
GO:0033002	muscle cell proliferation	3.13	1.00e-03	1.19e-02	10/49	S1PR1; STAT1; HPGD; AIF1; MYB; AKR1B1; FGFR1; PRKDC; CYBA; CCL5
GO:0043270	positive regulation of ion transport	3.13	5.76e-04	7.76e-03	11/54	PARK7; GLRX; TMSB4X; FLNA; ORAI1; LGALS3; CALM1; ANXA2; ARRB2; CCL5; TSPO
GO:0008037	cell recognition	3.07	3.64e-03	2.94e-02	8/40	MSN; CSGALNACT1; PRF1; LGALS3; MFGE8; CORO1A; CCR7; CD226
GO:1901342	regulation of vasculature development	3.03	8.70e-05	1.92e-03	15/76	JAK1; GLUL; CYP1B1; STAT1; HSPB1; ANXA1; ITGB1; HDAC7; RGCC; HIF1A; PKM; CIB1; PRKCB; TMIGD2; KLF2
GO:0022407	regulation of cell-cell adhesion	3.01	2.88e-08	3.00e-06	30/153	TNFAIP8L2; CD55; ITGA6; ITGA4; CD47; IL7R; IL6ST; CD74; FAM65B; HLA-E; AIF1; HLA-DPB1; MYB; MAD1L1; PAG1; ANXA1; CD44; C10orf54; RGCC; LGALS3; CORO1A; PYCARD; LGALS9; CCL5; CCR7; SIRPG; TMIGD2; FXYD5; SPINT2; LGALS1
GO:2000147	positive regulation of cell motility	3.01	2.88e-08	3.00e-06	30/153	S1PR1; RHOC; ITGA6; ITGA4; CD74; FAM65B; AIF1; GPSM3; HSPB1; CBLL1; TMSB4X; FLNA; FGFR1; GLIPR2; ANXA1; RRAS2; C10orf54; HDAC7; LGALS3; HIF1A; SYNE2; CIB1; CORO1A; PYCARD; TRADD; PFN1; LGALS9; CCL5; CCR7; SUN2
GO:0032635	interleukin-6 production	2.99	4.28e-03	3.21e-02	8/41	FCER1G; CAPN2; CD47; PYCARD; CYBA; ARRB2; LGALS9; KLF2
GO:0034341	response to interferon-gamma	2.96	6.84e-05	1.61e-03	16/83	JAK1; STAT1; CD47; HLA-E; AIF1; HLA-DRA; HLA-DQA1; HLA-DPB1; CD44; VIM; GAPDH; B2M; MT2A; LGALS9; CCL5; RPL13A
GO:0072511	divalent inorganic cation transport	2.91	3.93e-06	1.79e-04	22/116	BIN1; SLC39A10; CCDC109B; ANXA5; ORAI2; SARAF; AHNAK; ATP2B1; ORAI1; TPT1; RASA3; LGALS3; CALM1; ANXA2; IL16; PRKCB; CORO1A; CYBA; ARRB2; CCL5; CCR7; TSPO
GO:0070661	leukocyte proliferation	2.90	1.18e-05	4.10e-04	20/106	CD55; SLC39A10; IL7R; IL6ST; CD74; HLA-E; AIF1; HLA-DPB1; MAD1L1; MSN; ANXA1; C10orf54; GPR183; LGALS3; CORO1A; PYCARD; LGALS9; CCL5; IKZF3; TMIGD2
GO:0070972	protein localization to endoplasmic reticulum	2.89	2.62e-06	1.40e-04	23/122	RPL11; RPL37A; RPSA; RPL14; RPL9; RPS18; RPS4X; RPL36A; RPS20; RPL12; RPL7A; RPS25; RPS24; RPL6; RPS29; RPLP1; RPS2; RPS15A; RPL26; RPL23; PPP1R15A; RPL13A; RPL28
GO:0042110	T cell activation	2.88	8.06e-10	1.60e-07	39/208	CD2; TNFAIP8L2; FCER1G; RAB29; CD55; ZFP36L2; CD8B; CD47; IL7R; IL6ST; TCF7; CD74; FAM65B; HLA-E; AIF1; HLA-DPB1; MYB; MAD1L1; MSN; PRKDC; PAG1; ANXA1; CD3D; C10orf54; GPR183; LGALS3; BATF; B2M; LAT; CORO1A; ITGAL; PYCARD; LGALS9; CCL5; CCR7; CD7; SIRPG; TMIGD2; LGALS1
GO:0010959	regulation of metal ion transport	2.87	6.17e-05	1.50e-03	17/91	BIN1; GLRX; FLNA; SARAF; AHNAK; ORAI1; LGALS3; CALM1; B2M; ANXA2; IL16; CORO1A; CYBA; ARRB2; CCL5; FXYD5; TSPO
GO:0051291	protein heterooligomerization	2.86	5.79e-03	4.10e-02	8/43	S100A10; LIMS1; CD74; SQSTM1; BIRC3; GCHFR; ANXA2; TRADD
GO:0070371	ERK1 and ERK2 cascade	2.83	3.20e-04	5.19e-03	14/76	ZFP36L2; CD74; FGFR1; MYC; GLIPR2; CD44; EIF3A; GPR183; CIB1; PYCARD; ARRB2; LGALS9; CCL5; CCR7
GO:0007015	actin filament organization	2.81	2.69e-06	1.40e-04	24/131	STMN1; S1PR1; RHOC; S100A10; CDC42EP3; ARHGAP25; TMSB10; CAPG; BIN1; TTN; CD47; IQGAP2; AIF1; TMSB4X; FLNA; ITGB1; ADD3; PXN; RGCC; CORO1A; PYCARD; PFN1; CCR7; DSTN
GO:0007162	negative regulation of cell adhesion	2.81	2.13e-04	3.70e-03	15/82	TNFAIP8L2; CYP1B1; CD74; FAM65B; MAD1L1; CBLL1; PAG1; ANXA1; C10orf54; RGCC; LGALS3; LGALS9; FXYD5; SPINT2; LGALS1
GO:0050727	regulation of inflammatory response	2.80	3.16e-05	9.34e-04	19/104	PARK7; TNFAIP8L2; FCER1G; CD55; CD47; IL6ST; HLA-E; GPSM3; NT5E; TMSB4X; ANXA1; CD59; BIRC3; NFKBIA; PYCARD; TRADD; CCL5; CCR7; GPX4
GO:0050867	positive regulation of cell activation	2.79	3.10e-06	1.50e-04	24/132	CD2; FCER1G; CD55; SLC39A10; CD47; IL7R; IL6ST; CD74; HLA-E; AIF1; HLA-DPB1; MYB; ANXA1; C10orf54; GPR183; CORO1A; PYCARD; LGALS9; CCL5; CCR7; CD226; SIRPG; TMIGD2; LGALS1
GO:0006413	translational initiation	2.78	2.98e-07	2.17e-05	29/160	RPL11; RPL37A; RPSA; RPL14; RPL9; NPM1; RPS18; HSPB1; RPS4X; RPL36A; RPS20; PABPC1; RPL12; RPL7A; RPS25; RPS24; EIF3A; RPL6; RPS29; RPLP1; RPS2; RPS15A; RPL26; CCL5; RPL23; EIF1; PPP1R15A; RPL13A; RPL28
GO:0003012	muscle system process	2.76	1.63e-04	3.12e-03	16/89	BIN1; TTN; MYL5; ITGA1; IL6ST; AIF1; FLNA; VIM; VCL; C12orf57; MYL6B; PXN; CALM1; CYBA; MYL12A; EEF2
GO:1902903	regulation of supramolecular fiber organization	2.76	6.15e-06	2.36e-04	23/128	PARK7; STMN1; S1PR1; RHOC; S100A10; CDC42EP3; TMSB10; CAPG; BIN1; CD47; IQGAP2; TMSB4X; FLNA; HSPA8; ADD3; PXN; RGCC; CIB1; CORO1A; PYCARD; PFN1; CCR7; DSTN
GO:0031589	cell-substrate adhesion	2.70	2.13e-04	3.70e-03	16/91	S100A10; LIMS1; ITGA6; ITGA4; ITGA1; FLNA; CD44; ITGB1; VCL; ITGB7; PXN; CIB1; CORO1A; ITGAL; CCR7; LGALS1
GO:0071706	tumor necrosis factor superfamily cytokine production	2.68	2.19e-03	2.01e-02	11/63	CD2; FCER1G; CD47; HLA-E; HSPB1; C10orf54; PYCARD; CYBA; ARRB2; LGALS9; TSPO
GO:0045785	positive regulation of cell adhesion	2.68	2.66e-06	1.40e-04	26/149	S100A10; CD55; LIMS1; ITGA6; ITGA4; CD47; IL7R; IL6ST; CD74; HLA-E; AIF1; HLA-DPB1; MYB; FLNA; ANXA1; CD44; C10orf54; CIB1; CORO1A; PYCARD; LGALS9; CCL5; CCR7; SIRPG; TMIGD2; LGALS1
GO:0001525	angiogenesis	2.65	4.69e-05	1.18e-03	20/116	JAK1; S1PR1; GLUL; CYP1B1; STAT1; HSPB1; FGFR1; ANXA1; ITGB1; HDAC7; RGCC; HIF1A; ANXA2; PKM; MFGE8; CIB1; PRKCB; STK4; TMIGD2; KLF2
GO:0050866	negative regulation of cell activation	2.65	3.78e-03	2.96e-02	10/58	TNFAIP8L2; CD74; FAM65B; MAD1L1; PAG1; ANXA1; TSPAN32; C10orf54; LGALS3; LGALS9
GO:0032970	regulation of actin filament-based process	2.64	3.10e-05	9.34e-04	21/122	STMN1; S1PR1; RHOC; S100A10; CDC42EP3; TMSB10; CAPG; BIN1; CD47; IQGAP2; TMSB4X; FLNA; ADD3; PXN; RGCC; CORO1A; PYCARD; PFN1; CCR7; DSTN; CNN2
GO:0090130	tissue migration	2.59	5.38e-04	7.39e-03	15/89	GLUL; CYP1B1; STAT1; HSPB1; TMSB4X; FGFR1; GLIPR2; ANXA1; ITGB1; HDAC7; PXN; RGCC; HIF1A; CIB1; PFN1
GO:0072507	divalent inorganic cation homeostasis	2.58	4.52e-05	1.17e-03	21/125	CD52; S1PR1; CD55; CXCR4; SLC39A10; CCDC109B; ANXA5; P2RY8; ATP2B1; TPT1; RASA3; PTGER2; CALM1; ANXA2; PRKCB; CORO1A; MT2A; CYBA; CCL5; CCR7; S1PR4
GO:0002694	regulation of leukocyte activation	2.56	3.41e-07	2.26e-05	33/198	CD2; TNFAIP8L2; FCER1G; CD55; ZFP36L2; SLC39A10; CD47; IL7R; IL6ST; CD74; FAM65B; HLA-E; AIF1; HLA-DPB1; MYB; MAD1L1; PAG1; ANXA1; TSPAN32; C10orf54; GPR183; LGALS3; LAT; CORO1A; PYCARD; LGALS9; CCL5; IKZF3; CCR7; CD226; SIRPG; TMIGD2; LGALS1
GO:0002683	negative regulation of immune system process	2.53	8.17e-06	2.97e-04	26/158	TNFAIP8L2; FCER1G; CD55; CD47; IL7R; CD74; FAM65B; HLA-E; MAD1L1; TSC22D3; PRKDC; PAG1; MYC; ANXA1; TSPAN32; CD59; C10orf54; ELF1; NFKBIA; LGALS3; GPR68; KLF13; CIB1; ARRB2; LGALS9; SAMHD1
GO:0001819	positive regulation of cytokine production	2.51	6.06e-06	2.36e-04	27/165	PARK7; CD2; FCER1G; CYP1B1; STAT1; IL6ST; CD74; HLA-E; LTB; GPSM3; HLA-DPB1; MYB; HSPB1; PRKDC; ANXA1; BIRC3; NFKB2; GAPDH; RGCC; HIF1A; B2M; PYCARD; CYBA; LGALS9; CCR7; CD226; TMIGD2
GO:0006909	phagocytosis	2.50	7.72e-04	9.81e-03	15/92	CDC42SE1; FCER1G; ARHGAP25; CD47; LYAR; AIF1; ANXA1; ITGB1; BIN2; MFGE8; CORO1A; ITGAL; PYCARD; CYBA; SIRPG
GO:0042063	gliogenesis	2.48	4.06e-03	3.15e-02	11/68	BIN1; CXCR4; IL6ST; MYB; ANXA1; VIM; GPR183; SYNE2; EEF2; SUN2; TSPO
GO:0050817	coagulation	2.46	4.26e-04	6.20e-03	17/106	FCER1G; H3F3A; DGKD; RAP2B; ANXA5; CLIC1; HSPB1; FLNA; GNAQ; TSPAN32; CD59; VCL; ENTPD1; ANXA2; PRKCB; ARRB2; MYL12A
GO:0045861	negative regulation of proteolysis	2.45	2.09e-04	3.70e-03	19/119	PARK7; RPL11; CD55; BIN1; CAST; TNFAIP8; SERPINB6; TIMP1; CD59; CD44; PRDX5; BIRC3; SORL1; GAPDH; PEBP1; GLG1; ARRB2; RPL23; SPINT2
GO:0002250	adaptive immune response	2.44	3.33e-05	9.34e-04	24/151	SLAMF7; FCER1G; CD55; CD8B; TRAT1; IL7R; IL6ST; CD74; HLA-E; SH2D1A; PAG1; ANXA1; CD3D; PRF1; NFKB2; ORAI1; GPR183; BATF; B2M; PRKCB; LAT; PYCARD; CD7; CD226
GO:0001667	ameboidal-type cell migration	2.42	3.54e-04	5.36e-03	18/114	GLUL; CYP1B1; ITGA4; STAT1; HSPB1; TMSB4X; TIMP1; FGFR1; GLIPR2; ANXA1; ITGB1; HDAC7; ITGB7; PXN; RGCC; HIF1A; CIB1; PFN1
GO:0050878	regulation of body fluid levels	2.39	9.49e-05	2.03e-03	22/141	STMN1; FCER1G; H3F3A; DGKD; RAP2B; ANXA5; CLIC1; HSPB1; AKR1B1; FLNA; AQP3; GNAQ; TSPAN32; CD59; VCL; ENTPD1; HIF1A; ANXA2; PRKCB; CYBA; ARRB2; MYL12A
GO:0060759	regulation of response to cytokine stimulus	2.39	3.76e-03	2.96e-02	12/77	JAK1; STAT1; CD74; BIRC3; ELF1; HIF1A; PYCARD; TRADD; CCL5; SAMHD1; AES; IFNAR2
GO:0002237	response to molecule of bacterial origin	2.37	1.35e-03	1.40e-02	15/97	CD55; CAPN2; HPGD; IL10RA; VIM; NFKB2; NFKBIA; PTGER2; B2M; LITAF; PYCARD; LGALS9; CCL5; CCR7; TSPO
GO:0048872	homeostasis of number of cells	2.37	3.25e-04	5.19e-03	19/123	FCER1G; STAT1; SKIL; LYAR; IL7R; CD74; SFXN1; TSC22D3; ANXA1; RPS24; GPR183; HIF1A; KLF13; B2M; LAT; CORO1A; LGALS9; CCR7; KLF2
GO:0051271	negative regulation of cellular component movement	2.36	4.19e-03	3.18e-02	12/78	CYP1B1; BIN1; SRGAP3; RAP2B; FAM65B; AIF1; TIMP1; VCL; OSBPL8; RGCC; LDLRAD4; SPINT2
GO:0051701	interaction with host	2.31	2.52e-03	2.21e-02	14/93	CD55; CXCR4; RPSA; CD74; THOC3; CBLL1; SLC25A6; ITGB1; GAPDH; ITGB7; SELPLG; SIVA1; LGALS9; LGALS1
GO:0051235	maintenance of location	2.31	9.08e-04	1.12e-02	17/113	PARK7; TMSB10; ANXA5; TMSB4X; FLNA; SORL1; SRGN; OSBPL8; RASA3; NFKBIA; SYNE2; CALM1; CORO1A; CYBA; CCR7; SUN2; TSPO
GO:0034612	response to tumor necrosis factor	2.26	3.09e-03	2.58e-02	14/95	ZFP36L2; LIMS1; TANK; STAT1; LTB; TMSB4X; BIRC3; NFKBIA; CIB1; PYCARD; TRADD; CYBA; CCL5; KLF2
GO:0002449	lymphocyte mediated immunity	2.26	2.27e-03	2.04e-02	15/102	SLAMF7; FCER1G; CD55; LYST; IL7R; CD74; HLA-E; SH2D1A; PRF1; BATF; B2M; CORO1A; ARRB2; LGALS9; CD226
GO:0010038	response to metal ion	2.23	2.50e-03	2.21e-02	15/103	PARK7; TXNIP; TTN; ANXA5; AQP3; FXN; RASGRP2; PEBP1; ALOX5AP; HIF1A; CALM1; B2M; MT2A; CYB5A; TSPO
GO:0034765	regulation of ion transmembrane transport	2.22	5.11e-03	3.65e-02	13/90	PARK7; BIN1; CRBN; GLRX; CLIC1; TMSB4X; FLNA; CLIC3; AHNAK; CALM1; CORO1A; CYBA; FXYD5
GO:0007249	I-kappaB kinase/NF-kappaB signaling	2.19	1.20e-03	1.28e-02	18/126	RHOC; S100A4; TANK; STAT1; CD74; SQSTM1; HSPB1; FLNA; BIRC3; OPTN; NFKBIA; LITAF; PRKCB; PYCARD; TRADD; LGALS9; CCR7; LGALS1
GO:1902532	negative regulation of intracellular signal transduction	2.18	3.25e-05	9.34e-04	30/211	PARK7; STMN1; ARHGAP25; RNF149; TANK; STAT1; CD74; FAM65B; STK38; HSPB1; TMSB4X; MYC; CD44; SESN3; SORL1; OPTN; ITGB1; DDIT4; EIF3A; HDAC7; PEBP1; TPT1; RASA3; HIF1A; CALM1; CIB1; LITAF; PYCARD; ARRB2; STMN3
GO:0002791	regulation of peptide secretion	2.14	1.16e-03	1.28e-02	19/136	CD2; GLUL; TTN; ANXA5; CD74; HLA-E; SLC25A6; TMSB4X; ANXA1; UCP2; SRGN; GAPDH; RGCC; HIF1A; GPR68; PYCARD; LGALS9; CCL5; CCR7
GO:0009636	response to toxic substance	2.13	4.07e-04	6.05e-03	23/166	PARK7; TXNIP; CAPN2; CYP1B1; STAT1; HPGD; MYB; GSTK1; FXN; ANXA1; PRDX5; FAM213A; RGS10; PEBP1; ALOX5AP; CALM1; MT2A; CCL5; GPX4; EEF2; KLF2; MPST; MT-ND5
GO:0051346	negative regulation of hydrolase activity	2.12	1.02e-03	1.19e-02	20/145	PARK7; CDC42SE1; BIN1; IQGAP2; CAST; TNFAIP8; SERPINB6; TIMP1; ANXA1; CD44; PRDX5; BIRC3; SORL1; GAPDH; PEBP1; LGALS3; GCHFR; ARRB2; SPINT2; PPP1R15A
GO:0002697	regulation of immune effector process	2.09	1.22e-03	1.28e-02	20/147	FCER1G; CD55; STAT1; CD47; IL7R; CD74; HLA-E; MYB; SH2D1A; PRKDC; ANXA1; TSPAN32; CD59; BIRC3; LGALS3; B2M; PYCARD; ARRB2; LGALS9; CD226
GO:0031349	positive regulation of defense response	2.07	7.81e-04	9.81e-03	22/163	PARK7; FCER1G; TANK; CD47; IL6ST; HLA-E; GPSM3; SLC25A6; SH2D1A; PRKDC; BIRC3; OPTN; NFKBIA; PYCARD; TRADD; CYBA; ARRB2; LGALS9; CCL5; CCR7; ICAM2; CD226
GO:0035690	cellular response to drug	2.06	4.15e-03	3.18e-02	16/119	PARK7; CYP1B1; RNF149; NR3C1; AIF1; MYB; MYC; FXN; ANXA1; GNAQ; VIM; DDIT4; RGS10; MT2A; CYBA; KLF2
GO:1903706	regulation of hemopoiesis	2.01	1.18e-03	1.28e-02	22/168	CD2; H3F3A; ZFP36L2; STAT1; IL7R; CD74; MYB; MYC; ANXA1; C10orf54; FAM213A; NFKBIA; LGALS3; HIF1A; GPR68; KLF13; B2M; CIB1; PRKCB; LGALS9; IKZF3; LGALS1
GO:0052547	regulation of peptidase activity	2.01	2.00e-03	1.91e-02	20/153	PARK7; BIN1; TANK; CAST; TNFAIP8; SERPINB6; TIMP1; MYC; CD44; PRDX5; BIRC3; SORL1; C10orf54; GAPDH; PEBP1; PYCARD; TRADD; ARRB2; LGALS9; SPINT2

Factor 5 : 14 significant GO terms

GeneSet	description	enrichRatio	pValue	FDR	GeneRatio	geneSymbols
GO:0070972	protein localization to endoplasmic reticulum	19.40	0.00e+00	0.00e+00	71/122	RPL22; RPL11; RPS8; RPL5; RPS7; RPS27A; RPL31; RPL37A; RPL32; RPL15; RPSA; RPL14; RPL29; RPL24; RPL35A; RPL9; RPL34; RPS3A; RPL37; RPS23; RPS14; RPS18; RPS10; RPL10A; RPS12; RPS4X; RPL36A; RPL39; RPL10; RPS20; RPL7; RPL30; RPL8; RPS6; RPL35; RPL12; RPL7A; RPLP2; RPL27A; RPS13; RPS3; RPS25; RPS24; RPL41; RPL6; RPLP0; RPL21; RPS29; RPL4; RPLP1; RPS17; RPS2; RPL13; RPL26; RPL23A; RPL19; RPL27; RPL38; RPS21; RPS15; RPL36; RPS28; RPL18A; RPS16; RPL18; RPL13A; RPS11; RPS9; RPL28; RPS5; RPL3
GO:0006413	translational initiation	16.30	0.00e+00	0.00e+00	78/160	RPL22; RPL11; RPS8; RPL5; RPS7; RPS27A; RPL31; RPL37A; RPL32; RPL15; RPSA; RPL14; RPL29; RPL24; RPL35A; RPL9; RPL34; RPS3A; RPL37; RPS23; RPS14; NPM1; RPS18; RPS10; RPL10A; RPS12; RPS4X; RPL36A; RPL39; RPL10; RPS20; RPL7; RPL30; PABPC1; EIF3E; EIF3H; RPL8; RPS6; RPL35; RPL12; RPL7A; RPLP2; RPL27A; RPS13; RPS3; RPS25; RPS24; RPL41; RPL6; RPLP0; RPL21; RPS29; RPL4; RPLP1; RPS17; RPS2; RPL13; RPL26; RPL23A; CCL5; RPL19; EIF1; RPL27; RPL38; RPS21; RPS15; RPL36; RPS28; RPL18A; RPS16; RPL18; RPL13A; RPS11; RPS9; RPL28; RPS5; EIF3L; RPL3
GO:0002181	cytoplasmic translation	15.00	0.00e+00	0.00e+00	32/71	RPL11; RPL31; RPL32; RPL15; RPL29; RPL24; RPL35A; RPL9; RPS23; RPL10A; RPL36A; RPL39; RPL30; EIF3E; EIF3H; RPL8; RPL41; RPL6; RPLP0; RPS29; RPLP1; RPL26; RPL19; RPL38; RPS21; EEF2; RPL36; RPS28; RPL18A; RPL18; RPL13A; EIF3L
GO:0090150	establishment of protein localization to membrane	11.90	0.00e+00	0.00e+00	73/205	RPL22; RPL11; RPS8; RPL5; RPS7; RPS27A; RPL31; RPL37A; RPL32; RPL15; RPSA; RPL14; RPL29; RPL24; RPL35A; RPL9; RPL34; RPS3A; RPL37; RPS23; RPS14; GNB2L1; RPS18; RPS10; RPL10A; RPS12; RPS4X; RPL36A; RPL39; RPL10; RPS20; RPL7; RPL30; RPL8; RPS6; RPL35; RPL12; RPL7A; RPLP2; RPL27A; RPS13; RPS3; RPS25; RPS24; RPL41; RPL6; RPLP0; RPL21; RPS29; RPL4; RPLP1; RPS17; RPS2; RPL13; RPL26; RPL23A; RPL19; RPL27; RPL38; RPS21; RPS15; RPL36; RPS28; RPL18A; RPS16; RPL18; BAX; RPL13A; RPS11; RPS9; RPL28; RPS5; RPL3
GO:0006401	RNA catabolic process	10.40	0.00e+00	0.00e+00	78/250	RPL22; RPL11; YBX1; RPS8; RPL5; RPS7; RPS27A; RPL31; RPL37A; RPL32; RPL15; RPSA; RPL14; RPL29; RPL24; RPL35A; RPL9; RPL34; RPS3A; RPL37; RPS23; RPS14; NPM1; RPS18; RPS10; RPL10A; RPS12; RPS4X; RPL36A; RPL39; RPL10; RPS20; RPL7; RPL30; PABPC1; EIF3E; RPL8; RPS6; RPL35; RPL12; RPL7A; RPLP2; RPL27A; RPS13; RPS3; RPS25; VIM; RPS24; RPL41; RPL6; RPLP0; UBC; RPL21; RPS29; RPL4; RPLP1; RPS17; RPS2; RPL13; RPL26; UBB; RPL23A; RPL19; RPL27; RPL38; RPS21; RPS15; RPL36; RPS28; RPL18A; RPS16; RPL18; RPL13A; RPS11; RPS9; RPL28; RPS5; RPL3
GO:0006605	protein targeting	9.66	0.00e+00	0.00e+00	75/259	RPL22; RPL11; RPS8; RPL5; RPS7; RPS27A; RPL31; RPL37A; RPL32; RPL15; RPSA; RPL14; RPL29; RPL24; RPL35A; RPL9; RPL34; RPS3A; RPL37; RPS23; RPS14; RPS18; RPS10; RPL10A; RPS12; SLC25A6; RPS4X; RPL36A; RPL39; RPL10; RPS20; RPL7; RPL30; RPL8; RPS6; RPL35; RPL12; RPL7A; RPLP2; RPL27A; RPS13; RPS3; RPS25; RPS24; RPL41; RPL6; RPLP0; UBC; RPL21; RPS29; RPL4; RPLP1; RPS17; RPS2; RPL13; RPL26; UBB; RPL23A; RPL19; RPL27; RPL38; RPS21; RPS15; RPL36; RPS28; RPL18A; RPS16; RPL18; RPL13A; RPS11; RPS9; RPL28; RPS5; RAC2; RPL3
GO:0006959	humoral immune response	6.07	3.71e-04	1.93e-02	6/33	PTPRC; HLA-E; RPL39; RPL30; GAPDH; C1QBP
GO:0016072	rRNA metabolic process	4.52	2.58e-10	2.35e-08	24/177	RPL11; RPS8; RPL5; RPS7; RPSA; RPL14; RPL35A; RPS14; RPL10A; RPL7; RPS6; RPL35; RPL7A; RPS24; NOP10; RPS17; RPS2; RPL26; RPL27; RPS21; RPS15; RPS28; RPS16; RPS9
GO:0071826	ribonucleoprotein complex subunit organization	4.22	1.15e-09	9.28e-08	24/190	RPL11; RPL5; RPSA; RPL24; RPS23; RPS14; NPM1; RPS10; HSP90AB1; RPL10; EIF3E; EIF3H; RPL12; RPL6; RPLP0; C1QBP; RPL23A; RPL38; RPS15; RPS28; RPL13A; RPS5; EIF3L; RPL3
GO:0022613	ribonucleoprotein complex biogenesis	4.10	4.44e-16	4.62e-14	42/342	RPL11; RPS8; RPL5; RPS7; RPSA; RPL14; RPL24; RPL35A; RPS23; RPS14; NPM1; RPS10; RPL10A; HSP90AB1; RPL10; RPL7; EIF3E; EIF3H; RPS6; RPL35; RPL12; RPL7A; RPS24; RPL6; RPLP0; NOP10; RPS17; RPS2; C1QBP; RPL26; RPL23A; RPL27; RPL38; RPS21; RPS15; RPS28; RPS16; RPL13A; RPS9; RPS5; EIF3L; RPL3
GO:0034470	ncRNA processing	3.39	8.88e-08	6.46e-06	24/236	RPL11; RPS8; RPL5; RPS7; RPSA; RPL14; RPL35A; RPS14; RPL10A; RPL7; RPS6; RPL35; RPL7A; RPS24; NOP10; RPS17; RPS2; RPL26; RPL27; RPS21; RPS15; RPS28; RPS16; RPS9
GO:0034248	regulation of cellular amide metabolic process	3.23	7.58e-07	5.02e-05	22/227	RPL5; RPS14; NPM1; GNB2L1; EEF1A1; RBM3; RPS4X; RPL10; PABPC1; EIF3E; EIF3H; RPS3; VIM; GAPDH; C1QBP; RPL26; CCL5; EIF1; RPL38; EEF2; RPL13A; RPS9
GO:0010608	posttranscriptional regulation of gene expression	2.80	1.89e-06	1.15e-04	25/298	YBX1; RPL5; RPS27A; RPS14; NPM1; GNB2L1; RBM3; RPS4X; RPL10; PABPC1; EIF3E; EIF3H; RPS3; VIM; GAPDH; UBC; C1QBP; RPL26; UBB; CCL5; EIF1; RPL38; EEF2; RPL13A; RPS9
GO:0042110	T cell activation	2.73	1.36e-04	7.63e-03	17/208	LCK; CD2; PTPRC; CD8B; HLA-E; RPS6; RPS3; CD3E; CD3D; CD27; LGALS3; B2M; LAT; CCL5; CD7; BAX; RAC2

Factor 6 : 61 significant GO terms

GeneSet	description	enrichRatio	pValue	FDR	GeneRatio	geneSymbols
GO:0042092	type 2 immune response	10.40	5.09e-05	1.32e-03	5/10	NDFIP1; CD74; ANXA1; GATA3; IL4R
GO:1990868	response to chemokine	8.57	6.99e-06	2.83e-04	7/17	FAM65B; CXCR3; CCL5; CCL3; CCL3L3; CCL4L2; CCR7
GO:0042116	macrophage activation	7.93	3.00e-06	1.45e-04	8/21	JUN; PTPRC; CD74; NAMPT; MFHAS1; HMGB1; IL4R; APP
GO:0050918	positive chemotaxis	6.93	1.90e-03	2.71e-02	4/12	HMGB2; HMGB1; CCL5; CCL3
GO:0002437	inflammatory response to antigenic stimulus	6.12	9.46e-04	1.60e-02	5/17	HMGB2; IL2RA; GATA3; HMGB1; CCR7
GO:0006968	cellular defense response	5.94	3.42e-04	6.91e-03	6/21	GNLY; SH2D1A; ITGB1; PRF1; KLRG1; KLRC2
GO:0098742	cell-cell adhesion via plasma-membrane adhesion molecules	5.94	3.42e-04	6.91e-03	6/21	SELL; JAML; ITGB1; ITGAL; PECAM1; FXYD5
GO:0006959	humoral immune response	5.67	1.65e-05	5.00e-04	9/33	PTPRC; GNLY; HLA-DQB1; SH2D1A; CD81; GATA3; GPR183; CCR7; RPS19
GO:0070670	response to interleukin-4	5.20	2.11e-03	2.76e-02	5/20	TCF7; HSPA5; GATA3; IL4R; XBP1
GO:0060326	cell chemotaxis	4.99	8.16e-09	1.37e-06	18/75	LYST; HMGB2; CD74; FAM65B; TMSB4X; CXCR3; ANXA1; CORO1B; JAML; HMGB1; GPR183; CCL5; CCL3; CCL3L3; CCL4L2; CCR7; CALR; RPS19
GO:0050920	regulation of chemotaxis	4.32	3.19e-05	8.92e-04	11/53	CD74; FAM65B; TMSB4X; CORO1B; HMGB1; GPR183; CCL5; CCL3; CCL4L2; CCR7; CALR
GO:0001906	cell killing	4.30	1.43e-05	4.74e-04	12/58	PRDX1; SLAMF7; PTPRC; LYST; GNLY; SH2D1A; PRF1; LAG3; GZMB; RAB27A; GZMM; RPS19
GO:0050866	negative regulation of cell activation	4.30	1.43e-05	4.74e-04	12/58	RUNX3; PTPRC; NDFIP1; CD74; FAM65B; ANXA1; IL2RA; LAG3; HMGB1; IL4R; PRNP; SAMSN1
GO:0032612	interleukin-1 production	4.30	2.16e-03	2.76e-02	6/29	GBP5; F2R; ANXA1; HMGB1; CCL3; CCR7
GO:0034341	response to interferon-gamma	4.26	2.62e-07	1.91e-05	17/83	GBP2; GBP4; GBP5; SEC61A1; HLA-DRA; HLA-DRB5; HLA-DRB1; HLA-DQA1; HLA-DQB1; HLA-DPA1; HLA-DPB1; IFITM2; CD44; CCL5; CCL3; CCL3L3; CCL4L2
GO:0050900	leukocyte migration	4.13	1.57e-09	3.82e-07	24/121	SELL; LYST; ITGA4; CD74; FAM65B; FYN; CXCR3; ANXA1; CD44; JAML; GATA3; ITGB1; HMGB1; GPR183; ITGAL; CCL5; CCL3; CCL3L3; CCL4L2; CCR7; PECAM1; CALR; RPS19; APP
GO:0070371	ERK1 and ERK2 cascade	4.11	2.23e-06	1.20e-04	15/76	JUN; PTPRC; F2R; CD74; MFHAS1; GLIPR2; CD44; HMGB1; GPR183; CCL5; CCL3; CCL3L3; CCL4L2; CCR7; APP
GO:0002449	lymphocyte mediated immunity	4.08	4.80e-08	3.98e-06	20/102	PRDX1; SLAMF7; PTPRC; LYST; CD8A; NDFIP1; CD74; HLA-DQB1; SH2D1A; GATA3; PRF1; CD27; LAG3; KLRD1; KLRC2; HMGB1; GZMB; RAB27A; IL4R; GZMM
GO:0007159	leukocyte cell-cell adhesion	4.05	4.42e-11	3.22e-08	29/149	RUNX3; SELL; PTPRC; ITGA4; ICOS; NDFIP1; CD74; FAM65B; HLA-DMB; HLA-DPA1; HLA-DPB1; FYN; ANXA1; CD44; IL2RA; GATA3; ITGB1; CD27; LAG3; TESPA1; HMGB1; IL4R; ITGAL; CCL5; CCR7; PECAM1; PRNP; TMIGD2; XBP1
GO:0070972	protein localization to endoplasmic reticulum	3.75	4.93e-08	3.98e-06	22/122	RPL11; RTN4; SEC61A1; SSR3; RPL9; SPCS3; RPS18; SEC61G; RPS4X; RPL10; RPS20; TRAM1; RPS6; SEC61B; HSPA5; RPL12; RPL7A; RPL27A; SPCS2; RPS15A; RPS19; RPL18
GO:0002285	lymphocyte activation involved in immune response	3.73	1.56e-05	4.95e-04	14/78	ZNF683; PTPRC; NDFIP1; HLA-DMB; ITM2A; RPS6; ANXA1; GATA3; HMGB1; GPR183; RAB27A; IL4R; ITGAL; XBP1
GO:0043062	extracellular structure organization	3.65	3.20e-04	6.91e-03	10/57	CAPG; ITGA4; TIMP1; CSGALNACT1; CD44; ITGB1; ITGAL; PECAM1; P4HB; APP
GO:0050867	positive regulation of cell activation	3.62	4.70e-08	3.98e-06	23/132	RUNX3; PTPRC; PLEK; ICOS; CD74; HLA-DMB; HLA-DPA1; HLA-DPB1; FYN; ANXA1; CD81; IL2RA; GATA3; CD27; TESPA1; HMGB1; GPR183; IL4R; CCL5; CCR7; TMIGD2; XBP1; APP
GO:0061448	connective tissue development	3.60	7.06e-04	1.32e-02	9/52	RUNX3; RUNX2; NAMPT; TIMP1; CSGALNACT1; CD44; PLA2G16; CHST11; XBP1
GO:0019882	antigen processing and presentation	3.58	6.77e-06	2.83e-04	16/93	CD8A; CD74; CANX; HLA-DRA; HLA-DRB5; HLA-DRB1; HLA-DQA1; HLA-DQB1; HLA-DMB; HLA-DPA1; HLA-DPB1; LAG3; PDIA3; RAB27A; CCR7; CALR
GO:0043491	protein kinase B signaling	3.57	1.02e-04	2.56e-03	12/70	THEM4; RTN4; ICOS; FYN; MFHAS1; MTDH; GATA3; ITGB1; CCL5; CCL3; CCR7; MYDGF
GO:0022407	regulation of cell-cell adhesion	3.54	1.02e-08	1.37e-06	26/153	RUNX3; PTPRC; ITGA4; ICOS; NDFIP1; CD74; FAM65B; HLA-DMB; HLA-DPA1; HLA-DPB1; FYN; ANXA1; CD44; IL2RA; GATA3; CD27; LAG3; TESPA1; HMGB1; IL4R; CCL5; CCR7; PRNP; TMIGD2; FXYD5; XBP1
GO:0038061	NIK/NF-kappaB signaling	3.47	9.39e-04	1.60e-02	9/54	PRDX1; LIMS1; TMSB4X; PDCD4; CD27; HMGB1; LITAF; CALR; APP
GO:0045454	cell redox homeostasis	3.47	3.46e-03	4.13e-02	7/42	PRDX1; PDIA6; GLRX; PDIA4; GLRX3; PDIA3; P4HB
GO:0042110	T cell activation	3.40	1.29e-10	4.71e-08	34/208	RUNX3; ZNF683; PTPRC; CD8A; CD8B; ICOS; TCF7; NDFIP1; CD74; FAM65B; HLA-DMB; HLA-DPA1; HLA-DPB1; RUNX2; FYN; RPS6; ANXA1; JAML; IL2RA; GATA3; CD27; LAG3; TESPA1; HMGB1; GPR183; RAB27A; IL4R; ITGAL; CCL5; CCR7; CD7; PRNP; TMIGD2; XBP1
GO:0032103	positive regulation of response to external stimulus	3.39	4.91e-05	1.32e-03	14/86	GBP5; CD74; FAM65B; TMSB4X; PDCD4; HMGB1; CCL5; CCL3; CCL3L3; CCL4L2; CCR7; CALR; RPS19; APP
GO:0032409	regulation of transporter activity	3.34	1.23e-03	1.91e-02	9/56	GLRX; NDFIP1; ACTB; TMSB4X; STOM; PRNP; FXYD7; FXYD5; APP
GO:0070661	leukocyte proliferation	3.34	9.28e-06	3.56e-04	17/106	PTPRC; NDFIP1; CD74; HLA-DMB; HLA-DPA1; HLA-DPB1; FYN; RPS6; ANXA1; CD81; IL2RA; HMGB1; GPR183; CCL5; IKZF3; PRNP; TMIGD2
GO:0045785	positive regulation of cell adhesion	3.21	4.67e-07	3.09e-05	23/149	RUNX3; PTPRC; LIMS1; ITGA4; ICOS; CD74; HLA-DMB; HLA-DPA1; HLA-DPB1; FYN; ANXA1; CD44; IL2RA; GATA3; CD27; TESPA1; HMGB1; IL4R; CCL5; CCR7; TMIGD2; CALR; XBP1
GO:0050663	cytokine secretion	3.20	9.45e-04	1.60e-02	10/65	GBP5; F2R; TMSB4X; ANXA1; GATA3; HMGB1; IL4R; CCL3; CCR7; XBP1
GO:0050727	regulation of inflammatory response	3.20	2.93e-05	8.53e-04	16/104	GBP5; PTPRC; NDFIP1; TMSB4X; MFHAS1; ANXA1; CD81; IL2RA; GATA3; PDCD4; CCL5; CCL3; CCL3L3; CCR7; RPS19; APP
GO:0002694	regulation of leukocyte activation	3.15	1.13e-08	1.37e-06	30/198	RUNX3; ZNF683; PTPRC; ICOS; NDFIP1; CD74; FAM65B; HLA-DMB; HLA-DPA1; HLA-DPB1; FYN; MFHAS1; ANXA1; CD81; IL2RA; GATA3; CD27; LAG3; TESPA1; HMGB1; GPR183; IL4R; CCL5; IKZF3; CCR7; PRNP; TMIGD2; XBP1; SAMSN1; APP
GO:0007162	negative regulation of cell adhesion	3.04	4.76e-04	9.12e-03	12/82	RUNX3; PTPRC; NDFIP1; CD74; FAM65B; ANXA1; IL2RA; LAG3; HMGB1; IL4R; PRNP; FXYD5
GO:0002250	adaptive immune response	3.03	2.30e-06	1.20e-04	22/151	ZNF683; SLAMF7; PTPRC; CD8A; CD8B; KLHL6; NDFIP1; CD74; HLA-DQB1; FYN; SH2D1A; ANXA1; GATA3; PRF1; CD27; HMGB1; GPR183; RAB27A; IL4R; CD7; GZMM; SAMSN1
GO:0050673	epithelial cell proliferation	2.91	4.40e-04	8.66e-03	13/93	RUNX3; JUN; RTN4; LIMS1; ITGA4; HMGB2; JAML; GATA3; HMGB1; CCL5; ERN1; MYDGF; XBP1
GO:0035821	modification of morphology or physiology of other organism	2.88	3.56e-03	4.18e-02	9/65	JUN; GNLY; STOM; PRF1; PPIB; CCL5; CCL3; CCL4L2; RPS19
GO:2000147	positive regulation of cell motility	2.86	1.03e-05	3.77e-04	21/153	JUN; PTPRC; RTN4; ITGA4; F2R; CD74; FAM65B; TMSB4X; GLIPR2; ANXA1; HSPA5; GATA3; HMGB1; SYNE2; CCL5; CCL3; CCL4L2; CCR7; CALR; XBP1; APP
GO:0007568	aging	2.82	1.40e-04	3.30e-03	16/118	JUN; LIMS1; SERP1; CISD2; CANX; NAMPT; TIMP1; PDCD4; LITAF; PRNP; RPN2; EEF2; CALR; TSPO; APP; MT-ATP6
GO:0090130	tissue migration	2.80	1.01e-03	1.64e-02	12/89	JUN; LGALS8; RTN4; TMSB4X; GLIPR2; ANXA1; CORO1B; GATA3; ITGB1; HMGB1; PECAM1; CALR
GO:0071216	cellular response to biotic stimulus	2.77	2.87e-03	3.48e-02	10/75	HMGB2; MTDH; HSPA5; PDCD4; HMGB1; LITAF; CCL5; CCL3; XBP1; TSPO
GO:0002521	leukocyte differentiation	2.77	9.85e-07	5.98e-05	27/203	RUNX3; ZNF683; JUN; PTPRC; CD8A; ITGA4; TCF7; NDFIP1; CD74; RUNX2; DNAJB9; ITM2A; RPS6; ANXA1; IL2RA; GATA3; ITGB1; CD27; TESPA1; HMGB1; GPR183; IL4R; CCL3; IKZF3; CCR7; XBP1; APP
GO:0010959	regulation of metal ion transport	2.74	1.24e-03	1.91e-02	12/91	F2R; GLRX; FYN; SARAF; STOM; CCL5; CCL3; CCL4L2; PRNP; FXYD7; FXYD5; TSPO
GO:0006909	phagocytosis	2.71	1.36e-03	2.06e-02	12/92	PTPRC; WIPF1; LYAR; FYN; ACTB; ANXA1; ITGB1; HMGB1; RAB27A; ITGAL; PECAM1; CALR
GO:0051235	maintenance of location	2.58	9.28e-04	1.60e-02	14/113	PTPRC; TMSB10; F2R; SYNE1; TMSB4X; HSPA5; FTH1; SORL1; HSP90B1; SYNE2; CCL3; CCR7; CALR; TSPO
GO:0002237	response to molecule of bacterial origin	2.57	2.16e-03	2.76e-02	12/97	JUN; HMGB2; F2R; MTDH; PDCD4; HMGB1; LITAF; CCL5; CCL3; CCR7; XBP1; TSPO
GO:0001667	ameboidal-type cell migration	2.55	1.01e-03	1.64e-02	14/114	JUN; LGALS8; RTN4; ITGA4; TMSB4X; TIMP1; GLIPR2; ANXA1; CORO1B; GATA3; ITGB1; HMGB1; PECAM1; CALR
GO:0042113	B cell activation	2.53	1.69e-03	2.46e-02	13/107	PTPRC; ITGA4; NDFIP1; CD74; DNAJB9; ITM2A; CD81; ITGB1; CD27; GPR183; IKZF3; XBP1; SAMSN1
GO:0034976	response to endoplasmic reticulum stress	2.52	1.59e-04	3.62e-03	19/157	JUN; FAM129A; PDIA6; MANF; SERP1; DNAJB9; PDIA4; SEC61B; HSPA5; HSP90B1; PDIA3; ERN1; P4HB; HM13; EEF2; MYDGF; CALR; SDF2L1; XBP1
GO:0006605	protein targeting	2.41	4.58e-06	2.09e-04	30/259	RPL11; SSR2; SEC61A1; SSR3; RPL9; SPCS3; RPS18; FYN; SEC61G; GSTK1; RPS4X; RPL10; GOLGA7; RPS20; TRAM1; RPS6; SEC61B; STOM; RPL12; RPL7A; RPL27A; SPCS2; SORL1; RAB27A; RPS15A; LMAN1; PRNP; RPS19; RPL18; TSPO
GO:0048872	homeostasis of number of cells	2.37	2.13e-03	2.76e-02	14/123	PRDX1; LYAR; HMGB2; F2R; CD74; MFHAS1; RPS6; ANXA1; IL2RA; GATA3; HMGB1; GPR183; CCR7; RPS19
GO:0090150	establishment of protein localization to membrane	2.33	1.06e-04	2.56e-03	23/205	RPL11; SSR2; SEC61A1; SSR3; RPL9; RPS18; FYN; RPS4X; RPL10; GOLGA7; RPS20; TRAM1; RPS6; SEC61B; STOM; RPL12; RPL7A; RPL27A; GZMB; RPS15A; PRNP; RPS19; RPL18
GO:0002697	regulation of immune effector process	2.26	1.68e-03	2.46e-02	16/147	ZNF683; PTPRC; NDFIP1; CD74; HLA-DMB; SH2D1A; ANXA1; CD81; IL2RA; GATA3; LAG3; HMGB1; IL4R; RPS19; XBP1; APOBEC3G
GO:0031349	positive regulation of defense response	2.17	1.94e-03	2.71e-02	17/163	GBP5; PYHIN1; HMGB2; FYN; SH2D1A; MFHAS1; PDCD4; LAG3; HSP90B1; HMGB1; RPS6KA5; CCL5; CCL3; CCL3L3; CCR7; RPS19; APP
GO:0002764	immune response-regulating signaling pathway	2.17	3.27e-04	6.91e-03	23/221	JUN; PTPRC; WIPF1; KLHL6; FYB; HLA-DRA; HLA-DRB5; HLA-DRB1; HLA-DQA1; HLA-DQB1; HLA-DPA1; HLA-DPB1; FYN; ACTB; MFHAS1; GATA3; TESPA1; HSP90B1; HMGB1; PRKCH; RPS6KA5; CCR7; PRNP
GO:0001819	positive regulation of cytokine production	2.14	2.21e-03	2.78e-02	17/165	GBP5; PTPRC; HMGB2; F2R; CD74; LTB; HLA-DPA1; HLA-DPB1; ANXA1; AGPAT2; GATA3; HMGB1; IL4R; CCL3; CCR7; TMIGD2; XBP1
GO:1903706	regulation of hemopoiesis	2.11	2.68e-03	3.31e-02	17/168	RUNX3; ZNF683; JUN; PTPRC; HMGB2; NDFIP1; CD74; ANXA1; IL2RA; GATA3; CD27; TESPA1; HMGB1; IL4R; CCL3; IKZF3; XBP1

Factor 7 : 29 significant GO terms

GeneSet	description	enrichRatio	pValue	FDR	GeneRatio	geneSymbols
GO:0051383	kinetochore organization	20.50	2.93e-05	1.33e-03	4/12	CENPF; SMC4; SMC2; NDC80
GO:0009262	deoxyribonucleotide metabolic process	13.30	2.71e-05	1.31e-03	5/23	DTYMK; NUDT1; RRM1; DUT; TYMS
GO:0015949	nucleobase-containing small molecule interconversion	12.30	1.65e-03	4.13e-02	3/15	DTYMK; DUT; TYMS
GO:0019692	deoxyribose phosphate metabolic process	10.70	4.57e-04	1.59e-02	4/23	DTYMK; NUDT1; DUT; TYMS
GO:0051321	meiotic cell cycle	9.44	6.48e-08	7.23e-06	10/65	ASPM; SMC4; PTTG1; RAD21; CKS2; SMC2; BUB3; UBB; TOP2A; CDC25B
GO:0006333	chromatin assembly or disassembly	8.77	1.35e-07	9.79e-06	10/70	HP1BP3; ITGB3BP; HMGB2; HIST1H1C; HIST1H1E; HIST1H1D; HIST1H1B; ANP32B; HMGB1; CENPM
GO:0071103	DNA conformation change	8.53	1.05e-10	2.54e-08	15/108	HP1BP3; ITGB3BP; SMC4; HMGB2; HIST1H1C; HIST1H1E; HIST1H1D; HIST1H1B; HNRNPA2B1; ANP32B; SMC2; HMGB1; NUSAP1; TOP2A; CENPM
GO:1904029	regulation of cyclin-dependent protein kinase activity	8.08	3.34e-04	1.21e-02	5/38	CKS1B; CCNG2; HSP90AB1; CKS2; CDKN2D
GO:0048285	organelle fission	7.80	3.11e-15	2.26e-12	23/181	ASPM; CENPF; SMC4; TACC3; CCNG2; MAD2L1; PTTG1; RAD21; CKS2; SMC2; KIF20B; BUB3; MKI67; MZT1; NUSAP1; KIF22; UBB; TOP2A; NDC80; CDC25B; TPX2; UBE2C; UBE2S
GO:0031109	microtubule polymerization or depolymerization	6.82	7.43e-04	2.35e-02	5/45	STMN1; CKAP5; CKAP2; MZT1; SKA2
GO:0034502	protein localization to chromosome	6.53	9.09e-04	2.45e-02	5/47	HIST1H1B; EZH2; RAD21; BUB3; NDC80
GO:0071824	protein-DNA complex subunit organization	6.37	2.33e-08	4.24e-06	14/135	HP1BP3; ITGB3BP; ANP32E; CENPF; PTMA; HMGB2; HIST1H1C; HIST1H1E; HIST1H1D; HIST1H1B; ANP32B; HMGB1; UBB; CENPM
GO:0044839	cell cycle G2/M phase transition	5.96	5.18e-06	3.14e-04	10/103	CENPF; TUBB; RAD21; CEP78; CNTRL; TUBB4B; CKAP5; TUBA1A; CDC25B; TPX2
GO:0007059	chromosome segregation	5.85	6.97e-08	7.23e-06	14/147	CENPF; SMC4; TACC3; MAD2L1; PTTG1; RAD21; SMC2; BUB3; MKI67; NUSAP1; KIF22; TOP2A; SKA2; NDC80
GO:0007051	spindle organization	5.58	7.83e-05	3.35e-03	8/88	STMN1; ASPM; TACC3; TUBB; CKAP5; MZT1; NDC80; TPX2
GO:1902850	microtubule cytoskeleton organization involved in mitosis	5.58	6.47e-04	2.14e-02	6/66	STMN1; TACC3; MZT1; NUSAP1; NDC80; TPX2
GO:0006310	DNA recombination	5.49	3.80e-06	2.51e-04	11/123	NUCKS1; WHSC1; HMGB2; HIST1H1C; HIST1H1E; HIST1H1D; HIST1H1B; RAD21; HMGB1; TOP2A; KPNA2
GO:0044772	mitotic cell cycle phase transition	5.34	3.58e-11	1.30e-08	22/253	CKS1B; CENPF; TACC3; MAD2L1; TUBB; DBF4; EZH2; RAD21; CEP78; CKS2; CNTRL; TUBB4B; CKAP5; BUB3; TUBA1A; TYMS; NDC80; CDC25B; TPX2; UBE2C; CDKN2D; UBE2S
GO:0010639	negative regulation of organelle organization	5.32	7.95e-08	7.23e-06	15/173	STMN1; CENPF; SPTBN1; MAD2L1; PTTG1; HIST1H1C; HIST1H1E; HIST1H1D; HIST1H1B; RAD21; ATAD2; BUB3; CKAP2; TOP2A; NDC80
GO:0000910	cytokinesis	5.26	8.86e-04	2.45e-02	6/70	STMN1; SPTBN1; KIF20B; CKAP2; NUSAP1; CDC25B
GO:0033044	regulation of chromosome organization	5.09	5.21e-08	7.23e-06	16/193	CENPF; TACC3; MAD2L1; PTTG1; HIST1H1C; HIST1H1E; HIST1H1D; HIST1H1B; HNRNPA2B1; RAD21; ATAD2; PHF19; BUB3; MKI67; TOP2A; NDC80
GO:1901987	regulation of cell cycle phase transition	4.81	1.14e-07	9.21e-06	16/204	CENPF; MAD2L1; TUBB; EZH2; RAD21; CEP78; CNTRL; TUBB4B; CKAP5; BUB3; TUBA1A; NDC80; CDC25B; TPX2; UBE2C; CDKN2D
GO:0045787	positive regulation of cell cycle	4.63	7.90e-06	4.42e-04	12/159	CKS1B; CCNG2; MAD2L1; HSP90AB1; EZH2; RAD21; CKS2; KIF20B; NUSAP1; NDC80; CDC25B; UBE2C
GO:0008213	protein alkylation	4.48	8.70e-04	2.45e-02	7/96	WHSC1; HIST1H1C; HIST1H1E; HIST1H1D; HIST1H1B; EZH2; PHF19
GO:0010948	negative regulation of cell cycle process	4.32	8.73e-05	3.53e-03	10/142	CENPF; MAD2L1; PTTG1; HSP90AB1; EZH2; RAD21; BUB3; CBX5; NDC80; CDKN2D
GO:0071897	DNA biosynthetic process	4.21	1.25e-03	3.24e-02	7/102	CENPF; HSP90AB1; HNRNPA2B1; KIAA0101; UBB; TYMS; CDKN2D
GO:0040029	regulation of gene expression, epigenetic	4.07	1.46e-04	5.60e-03	10/151	DEK; HIST1H1C; HIST1H1E; HIST1H1D; HIST1H1B; HNRNPA2B1; EZH2; ATAD2; PHF19; HMGB1
GO:0045930	negative regulation of mitotic cell cycle	3.99	7.92e-04	2.40e-02	8/123	CENPF; MAD2L1; PTTG1; EZH2; RAD21; BUB3; TOP2A; NDC80
GO:0051052	regulation of DNA metabolic process	3.95	1.83e-05	9.49e-04	13/202	USP1; NUCKS1; WHSC1; DEK; HIST1H1C; HIST1H1E; HIST1H1D; HIST1H1B; HSP90AB1; HNRNPA2B1; DBF4; HMGB1; KPNA2

Factor 8 : 23 significant GO terms

GeneSet	description	enrichRatio	pValue	FDR	GeneRatio	geneSymbols
GO:1990868	response to chemokine	13.60	1.67e-04	1.01e-02	4/17	CXCR6; CCL5; CCL3L3; CCL4L2
GO:0060191	regulation of lipase activity	12.80	2.12e-04	1.10e-02	4/18	RHOC; FGFR1; CCL5; S1PR4
GO:0070972	protein localization to endoplasmic reticulum	11.40	0.00e+00	0.00e+00	24/122	RPL5; RPS27; RPL37A; RPSA; RPL34; RPS18; RPS4X; RPL10; RPL30; RPL8; RPL7A; RPS3; RPL6; RPLP0; RPL21; RPLP1; RPS2; RPS15A; RPS15; RPS19; RPL13A; RPS9; RPL28; RPS5
GO:0006413	translational initiation	9.76	0.00e+00	0.00e+00	27/160	RPL5; RPS27; RPL37A; RPSA; RPL34; NPM1; RPS18; RPS4X; RPL10; RPL30; RPL8; RPL7A; RPS3; RPL6; RPLP0; RPL21; RPLP1; RPS2; RPS15A; EIF4A1; CCL5; RPS15; RPS19; RPL13A; RPS9; RPL28; RPS5
GO:0034109	homotypic cell-cell adhesion	9.64	1.40e-04	9.24e-03	5/30	CLIC1; FLNA; CCL5; ACTG1; LGALS1
GO:0090150	establishment of protein localization to membrane	7.05	2.00e-15	3.64e-13	25/205	RPL5; RPS27; RPL37A; RPSA; RPL34; RPS18; RPS4X; RPL10; RPL30; RPL8; RPL7A; RPS3; RPL6; RPLP0; RPL21; HSP90AA1; RPLP1; RPS2; RPS15A; RPS15; RPS19; RPL13A; RPS9; RPL28; RPS5
GO:0060326	cell chemotaxis	6.94	4.49e-06	5.45e-04	9/75	CXCR6; CD74; GPSM3; TMSB4X; FGFR1; CCL5; CCL3L3; CCL4L2; RPS19
GO:0050920	regulation of chemotaxis	6.54	2.69e-04	1.31e-02	6/53	CD74; GPSM3; TMSB4X; FGFR1; CCL5; CCL4L2
GO:0006401	RNA catabolic process	6.48	2.22e-16	5.39e-14	28/250	RPL5; RPS27; RPL37A; RPSA; RPL34; NPM1; RPS18; RPS4X; RPL10; RPL30; RPL8; RPL7A; RPS3; RPL6; RPLP0; UBC; RPL21; RPLP1; RPS2; CARHSP1; RPS15A; DDX5; RPS15; RPS19; RPL13A; RPS9; RPL28; RPS5
GO:0032103	positive regulation of response to external stimulus	6.05	1.41e-05	1.46e-03	9/86	CD74; GPSM3; TMSB4X; FGFR1; PDCD4; CCL5; CCL3L3; CCL4L2; RPS19
GO:0031032	actomyosin structure organization	6.02	1.31e-03	4.35e-02	5/48	RHOC; S100A10; TTN; ACTG1; CNN2
GO:0006605	protein targeting	5.80	5.55e-14	8.08e-12	26/259	RPL5; RPS27; RPL37A; RPSA; RPL34; RPS18; RPS4X; RPL10; RPL30; RPL8; RPL7A; RPS3; RPL6; RPLP0; UBC; RPL21; HSP90AA1; RPLP1; RPS2; RPS15A; RPS15; RPS19; RPL13A; RPS9; RPL28; RPS5
GO:0034341	response to interferon-gamma	5.57	7.92e-05	5.76e-03	8/83	HSP90AB1; GAPDH; B2M; CCL5; CCL3L3; CCL4L2; ACTG1; RPL13A
GO:0035821	modification of morphology or physiology of other organism	5.34	8.20e-04	3.47e-02	6/65	RPL30; GAPDH; CCL5; CCL4L2; TYMS; RPS19
GO:0002181	cytoplasmic translation	4.89	1.31e-03	4.35e-02	6/71	RPL30; RPL8; RPL6; RPLP0; RPLP1; RPL13A
GO:0050900	leukocyte migration	4.30	2.11e-04	1.10e-02	9/121	SELL; CD74; GPSM3; MYO1G; SLC3A2; CCL5; CCL3L3; CCL4L2; RPS19
GO:0034612	response to tumor necrosis factor	4.26	1.17e-03	4.26e-02	7/95	LTB; TMSB4X; RPS3; CCL5; CCL3L3; CCL4L2; CD70
GO:0071826	ribonucleoprotein complex subunit organization	3.96	1.84e-05	1.67e-03	13/190	RPL5; RPS27; RPSA; NPM1; HSP90AB1; RPL10; RPL6; RPLP0; HSP90AA1; RPS15; RPS19; RPL13A; RPS5
GO:0032970	regulation of actin filament-based process	3.79	1.12e-03	4.26e-02	8/122	RHOC; S100A10; TMSB10; TMSB4X; FLNA; ARHGDIB; CNN2; GMFG
GO:0007249	I-kappaB kinase/NF-kappaB signaling	3.67	1.38e-03	4.36e-02	8/126	RHOC; CD74; PRDX4; PIM2; FLNA; DDX21; UBC; LGALS1
GO:0016072	rRNA metabolic process	3.27	8.59e-04	3.47e-02	10/177	RPL5; RPS27; NCL; RPSA; RPL7A; DDX21; RPS2; RPS15; RPS19; RPS9
GO:0022613	ribonucleoprotein complex biogenesis	2.87	5.77e-05	4.66e-03	17/342	RPL5; RPS27; RPSA; NPM1; HSP90AB1; RPL10; RPL7A; DDX21; RPL6; RPLP0; HSP90AA1; RPS2; RPS15; RPS19; RPL13A; RPS9; RPS5
GO:0010608	posttranscriptional regulation of gene expression	2.72	5.09e-04	2.32e-02	14/298	RPL5; NCL; NPM1; RPS4X; RPL10; RPS3; GAPDH; UBC; CARHSP1; CCL5; DDX5; TYMS; RPL13A; RPS9

Factor 9 : 13 significant GO terms

GeneSet	description	enrichRatio	pValue	FDR	GeneRatio	geneSymbols
GO:0034109	homotypic cell-cell adhesion	10.70	4.71e-04	0.038124	4/30	ACTB; CCL5; ACTG1; MYL12A
GO:0006959	humoral immune response	9.72	6.84e-04	0.039547	4/33	PTPRC; HLA-E; CCR7; RPS19
GO:0001906	cell killing	6.91	7.06e-04	0.039547	5/58	PTPRC; HLA-E; B2M; CORO1A; RPS19
GO:0070972	protein localization to endoplasmic reticulum	6.57	2.00e-06	0.000728	10/122	RPS27; RPS18; RPS4X; RPL10; RPS24; RPL41; RPL13; RPL23; RPS28; RPS19
GO:0060326	cell chemotaxis	6.42	3.03e-04	0.031513	6/75	CXCR4; JAML; CORO1A; CCL5; CCR7; RPS19
GO:0006413	translational initiation	6.01	4.38e-07	0.000319	12/160	RPS27; RPS18; RPS4X; RPL10; RPS24; RPL41; RPL13; CCL5; RPL23; EIF1; RPS28; RPS19
GO:0002440	production of molecular mediator of immune response	6.01	4.31e-04	0.038124	6/80	PTPRC; CD96; HLA-E; ITM2A; TMBIM6; B2M
GO:0072507	divalent inorganic cation homeostasis	5.13	1.38e-04	0.025130	8/125	CD52; PTPRC; CXCR4; TMBIM6; TPT1; CORO1A; CCL5; CCR7
GO:0072511	divalent inorganic cation transport	4.84	5.34e-04	0.038884	7/116	PTPRC; SARAF; TMBIM6; TPT1; CORO1A; CCL5; CCR7
GO:0050900	leukocyte migration	4.64	6.89e-04	0.039547	7/121	SELL; CXCR4; JAML; CORO1A; CCL5; CCR7; RPS19
GO:0090150	establishment of protein localization to membrane	3.91	1.87e-04	0.027275	10/205	RPS27; RPS18; RPS4X; RPL10; RPS24; RPL41; RPL13; RPL23; RPS28; RPS19
GO:0006401	RNA catabolic process	3.85	4.57e-05	0.011090	12/250	RPS27; RPS18; RPS4X; RPL10; RPS24; RPL41; UBC; RPL13; RPL23; RPS28; HNRNPM; RPS19
GO:0006605	protein targeting	3.41	2.94e-04	0.031513	11/259	RPS27; RPS18; RPS4X; RPL10; RPS24; RPL41; UBC; RPL13; RPL23; RPS28; RPS19

Factor 10 : 54 significant GO terms

GeneSet	description	enrichRatio	pValue	FDR	GeneRatio	geneSymbols
GO:0050918	positive chemotaxis	13.10	2.01e-05	7.32e-04	5/12	LGALS3; IL16; CORO1A; CCL5; CCL3
GO:0045730	respiratory burst	9.68	5.61e-04	1.28e-02	4/13	CD52; RPS19; NCF4; RAC2
GO:0006968	cellular defense response	8.99	3.42e-05	1.08e-03	6/21	GNLY; TRAT1; LSP1; ITGB1; PRF1; KLRC2
GO:0006959	humoral immune response	7.63	6.15e-06	2.63e-04	8/33	GNLY; HLA-DQB1; RPL39; CD59; GAPDH; GPR183; BST2; RPS19
GO:0098742	cell-cell adhesion via plasma-membrane adhesion molecules	7.49	4.10e-04	1.03e-02	5/21	CD84; TGFBR2; CD164; JAML; ITGB1
GO:1990868	response to chemokine	7.40	1.69e-03	2.80e-02	4/17	CXCR4; CCL5; CCL3; CCL4L2
GO:0035456	response to interferon-beta	6.62	2.62e-03	3.81e-02	4/19	PYHIN1; STAT1; IFITM2; BST2
GO:0034341	response to interferon-gamma	6.07	4.16e-09	7.33e-07	16/83	STAT1; TXK; HLA-DRA; HLA-DRB5; HLA-DRB1; HLA-DQB1; HLA-DPA1; HLA-DPB1; IFITM2; GAPDH; EVL; B2M; CCL5; CCL3; CCL4L2; BST2
GO:0001906	cell killing	5.97	1.48e-06	1.07e-04	11/58	GNLY; HAVCR2; NCR3; CTSC; PRF1; GAPDH; LAG3; GZMB; B2M; CORO1A; RPS19
GO:0060326	cell chemotaxis	5.87	6.30e-08	6.56e-06	14/75	FCER1G; CXCR4; ITGA1; CD74; JAML; GPR183; LGALS3; IL16; CORO1A; CCL5; CCL3; CCL4L2; RPS19; RAC2
GO:0007229	integrin-mediated signaling pathway	5.39	7.08e-04	1.52e-02	6/35	FCER1G; ITGA1; ITGB1; CD63; FUT8; LAT
GO:0071887	leukocyte apoptotic process	5.24	1.11e-04	3.38e-03	8/48	FCER1G; CD74; CD3G; IL2RA; CD27; LGALS3; CCL5; ADA
GO:0002250	adaptive immune response	5.00	2.97e-11	1.08e-08	24/151	CD84; CD48; FCER1G; CD8A; CD8B; TRAT1; TXK; CD74; HAVCR2; HLA-DQB1; THEMIS; CTSC; CD3D; CD3G; PRF1; CD27; GPR183; B2M; PRKCB; LAT; CD7; ADA; LAIR1; SAMSN1
GO:0050900	leukocyte migration	4.94	5.03e-09	7.33e-07	19/121	CD2; CD84; CD48; FCER1G; CXCR4; ITGA1; CD74; JAML; ITGB1; GPR183; LGALS3; IL16; CORO1A; CCL5; CCL3; CCL4L2; ADA; RPS19; RAC2
GO:0002449	lymphocyte mediated immunity	4.94	9.05e-08	8.23e-06	16/102	FCER1G; CD8A; CD96; CD74; HAVCR2; NCR3; HLA-DQB1; CTSC; PRF1; CD27; LAG3; KLRD1; KLRC2; GZMB; B2M; CORO1A
GO:0032609	interferon-gamma production	4.84	1.28e-03	2.33e-02	6/39	CD2; CD96; TXK; HAVCR2; HLA-DPA1; HLA-DPB1
GO:0008277	regulation of G protein-coupled receptor signaling pathway	4.77	3.51e-03	4.88e-02	5/33	RGS10; CCL5; PDE6G; ADA; YWHAB
GO:0050920	regulation of chemotaxis	4.75	2.29e-04	6.40e-03	8/53	CXCR4; CD74; GPR183; IL16; CCL5; CCL3; CCL4L2; RAC2
GO:0008037	cell recognition	4.72	1.47e-03	2.58e-02	6/40	HAVCR2; NCR3; PRF1; CD9; LGALS3; CORO1A
GO:0042110	T cell activation	4.69	1.56e-13	1.13e-10	31/208	CD2; FCER1G; ZFP36L2; CD8A; CD8B; SATB1; TGFBR2; TCF7; CD74; HAVCR2; HLA-DPA1; HLA-DPB1; THEMIS; JAML; CD3D; CD3G; IL2RA; CD27; LAG3; GPR183; LGALS3; ZFP36L1; B2M; LAT; CORO1A; CCL5; CD7; ADA; XBP1; RAC2; LGALS1
GO:0019882	antigen processing and presentation	4.40	5.90e-06	2.63e-04	13/93	FCER1G; CD8A; KIF2A; CD74; HLA-DRA; HLA-DRB5; HLA-DRB1; HLA-DQB1; HLA-DPA1; HLA-DPB1; CTSD; LAG3; B2M
GO:0050866	negative regulation of cell activation	4.34	4.32e-04	1.05e-02	8/58	CD84; CD74; HAVCR2; IL2RA; CD9; LAG3; LGALS3; SAMSN1
GO:0070661	leukocyte proliferation	4.16	5.05e-06	2.63e-04	14/106	SATB1; TGFBR2; CD74; HAVCR2; HLA-DPA1; HLA-DPB1; IL2RA; GPR183; LGALS3; CORO1A; CCL5; IKZF3; ADA; RAC2
GO:0070371	ERK1 and ERK2 cascade	4.14	1.24e-04	3.60e-03	10/76	ZFP36L2; CD74; HAVCR2; EZR; EIF3A; GPR183; ZFP36L1; CCL5; CCL3; CCL4L2
GO:0042113	B cell activation	4.12	5.66e-06	2.63e-04	14/107	ZFP36L2; DOCK10; CD74; ITGB1; CD27; GPR183; ZFP36L1; PRKCB; IKZF3; ADA; BST2; XBP1; LGALS1; SAMSN1
GO:0002521	leukocyte differentiation	3.88	3.05e-09	7.33e-07	25/203	CD2; FCER1G; ZFP36L2; CD8A; DOCK10; SATB1; TGFBR2; TCF7; CD74; THEMIS; CD3D; CD3G; IL2RA; ITGB1; CD27; GPR183; LGALS3; ZFP36L1; B2M; EVI2B; CCL3; IKZF3; ADA; XBP1; LGALS1
GO:0002694	regulation of leukocyte activation	3.81	9.04e-09	1.10e-06	24/198	CD2; CD84; FCER1G; ZFP36L2; TGFBR2; CD74; HAVCR2; HLA-DPA1; HLA-DPB1; IL2RA; CD27; LAG3; GPR183; LGALS3; ZFP36L1; LAT; CORO1A; CCL5; IKZF3; ADA; XBP1; RAC2; LGALS1; SAMSN1
GO:0032103	positive regulation of response to external stimulus	3.66	3.49e-04	9.09e-03	10/86	FCER1G; CD74; HAVCR2; IL16; TRADD; CCL5; CCL3; CCL4L2; RPS19; RAC2
GO:0002697	regulation of immune effector process	3.64	3.08e-06	2.04e-04	17/147	CD84; FCER1G; STAT1; CD96; CD74; HAVCR2; NCR3; CD59; BIRC3; IL2RA; LAG3; LGALS3; B2M; BST2; RPS19; XBP1; RAC2
GO:0002285	lymphocyte activation involved in immune response	3.63	7.33e-04	1.53e-02	9/78	FCER1G; DOCK10; HAVCR2; GPR183; LGALS3; CORO1A; ADA; XBP1; LGALS1
GO:0007159	leukocyte cell-cell adhesion	3.59	3.72e-06	2.26e-04	17/149	TGFBR2; CD74; HAVCR2; HLA-DPA1; HLA-DPB1; EZR; IL2RA; ITGB1; CD27; LAG3; LGALS3; CORO1A; CCL5; ADA; XBP1; RAC2; LGALS1
GO:0048872	homeostasis of number of cells	3.58	2.89e-05	9.55e-04	14/123	FCER1G; STAT1; DOCK10; LYAR; CD74; IL2RA; RPS24; GPR183; ZFP36L1; B2M; LAT; CORO1A; ADA; RPS19
GO:0050867	positive regulation of cell activation	3.58	1.51e-05	5.77e-04	15/132	CD2; FCER1G; TGFBR2; CD74; HAVCR2; HLA-DPA1; HLA-DPB1; IL2RA; CD27; GPR183; CORO1A; CCL5; ADA; XBP1; LGALS1
GO:0007162	negative regulation of cell adhesion	3.45	1.06e-03	2.08e-02	9/82	CD74; HAVCR2; CD164; IL2RA; CD9; LAG3; LGALS3; SPINT2; LGALS1
GO:0002683	negative regulation of immune system process	3.39	8.32e-06	3.36e-04	17/158	CD84; FCER1G; CD96; GPR171; CD74; HAVCR2; EZR; CD59; IL2RA; LAG3; LGALS3; ZFP36L1; CCL3; ADA; BST2; RPS19; SAMSN1
GO:1903706	regulation of hemopoiesis	3.37	4.70e-06	2.63e-04	18/168	CD2; ZFP36L2; STAT1; TGFBR2; GPR171; CD74; IL2RA; CD27; LGALS3; ZFP36L1; B2M; PRKCB; EVI2B; CCL3; IKZF3; ADA; XBP1; LGALS1
GO:0034612	response to tumor necrosis factor	3.31	7.80e-04	1.58e-02	10/95	ZFP36L2; STAT1; LTB; BIRC3; CD27; ZFP36L1; TRADD; CCL5; CCL3; CCL4L2
GO:0022407	regulation of cell-cell adhesion	3.29	2.24e-05	7.76e-04	16/153	TGFBR2; CD74; HAVCR2; HLA-DPA1; HLA-DPB1; IL2RA; CD9; CD27; LAG3; LGALS3; CORO1A; CCL5; ADA; SPINT2; XBP1; LGALS1
GO:0002440	production of molecular mediator of immune response	3.15	3.62e-03	4.88e-02	8/80	FCER1G; GALNT2; CD96; CD74; HLA-DQB1; B2M; BST2; XBP1
GO:0002764	immune response-regulating signaling pathway	3.13	1.33e-06	1.07e-04	22/221	FCER1G; TRAT1; TXK; TIFA; HAVCR2; NCR3; HLA-DRA; HLA-DRB5; HLA-DRB1; HLA-DQB1; HLA-DPA1; HLA-DPB1; THEMIS; EZR; BIRC3; CD3D; CD3G; LGALS3; PRKCB; LAT; ICAM2; ADA
GO:0010959	regulation of metal ion transport	3.11	2.22e-03	3.43e-02	9/91	CD84; CD63; LGALS3; B2M; IL16; CORO1A; CCL5; CCL3; CCL4L2
GO:0070972	protein localization to endoplasmic reticulum	2.84	1.57e-03	2.66e-02	11/122	RPS8; RPL5; RPL15; RPL14; RPL39; RPL35; RPS13; RPS24; RPL41; RPS15; RPS19
GO:0006413	translational initiation	2.75	4.96e-04	1.17e-02	14/160	RPS8; RPL5; RPL15; RPL14; RPL39; RPL35; RPS13; RPS24; EIF3A; RPL41; CCL5; EIF1; RPS15; RPS19
GO:0043900	regulation of multi-organism process	2.74	3.23e-04	8.70e-03	15/172	STAT1; CD74; HAVCR2; IFITM2; BIRC3; IL2RA; PRF1; GAPDH; CCL5; CCL3; CCL4L2; ADA; BST2; LGALS1; APOBEC3H
GO:0072511	divalent inorganic cation transport	2.71	3.56e-03	4.88e-02	10/116	CD84; ATP2B1; RASA3; LGALS3; IL16; PRKCB; CORO1A; CCL5; CCL3; CCL4L2
GO:0001819	positive regulation of cytokine production	2.67	6.77e-04	1.49e-02	14/165	CD2; FCER1G; STAT1; TXK; CD74; HAVCR2; LTB; HLA-DPA1; HLA-DPB1; BIRC3; GAPDH; B2M; CCL3; XBP1
GO:0098542	defense response to other organism	2.66	1.11e-03	2.12e-02	13/154	FCER1G; GNLY; STAT1; HAVCR2; RPL39; IFITM2; BIRC3; IL2RA; PRF1; GAPDH; BST2; RPS19; APOBEC3H
GO:0045088	regulation of innate immune response	2.57	1.49e-03	2.58e-02	13/159	PYHIN1; FCER1G; STAT1; CD96; TXK; TIFA; HAVCR2; NCR3; BIRC3; LAG3; CCL5; ICAM2; RPS19
GO:0009615	response to virus	2.53	2.56e-03	3.81e-02	12/149	ENO1; CXCR4; STAT1; IFITM2; BIRC3; IL2RA; PRF1; NPC2; CCL5; CCL4L2; BST2; APOBEC3H
GO:0045785	positive regulation of cell adhesion	2.53	2.56e-03	3.81e-02	12/149	TGFBR2; CD74; HAVCR2; HLA-DPA1; HLA-DPB1; IL2RA; CD27; CORO1A; CCL5; ADA; XBP1; LGALS1
GO:0030099	myeloid cell differentiation	2.53	1.15e-03	2.14e-02	14/174	FCER1G; STAT1; TGFBR2; GPR171; LYAR; CD74; GPR183; LGALS3; ZFP36L1; B2M; PRKCB; EVI2B; CCL3; RPS19
GO:0031349	positive regulation of defense response	2.51	1.86e-03	3.01e-02	13/163	PYHIN1; FCER1G; TXK; TIFA; HAVCR2; NCR3; BIRC3; LAG3; TRADD; CCL5; CCL3; ICAM2; RPS19
GO:2000147	positive regulation of cell motility	2.47	3.19e-03	4.56e-02	12/153	RHOC; TGFBR2; CD74; LGALS3; SYNE2; CORO1A; TRADD; CCL5; CCL3; CCL4L2; XBP1; RAC2
GO:0090150	establishment of protein localization to membrane	2.30	2.00e-03	3.17e-02	15/205	RPS8; RPL5; RPL15; RPL14; RPL39; GOLGA7; RPL35; RPS13; RPS24; RPL41; RILPL2; GZMB; YWHAB; RPS15; RPS19

Factor 11 : 33 significant GO terms

GeneSet	description	enrichRatio	pValue	FDR	GeneRatio	geneSymbols
GO:1990868	response to chemokine	10.00	9.49e-05	4.93e-03	5/17	CXCR6; CXCR3; CCL5; CCL3; CCL3L3
GO:0006968	cellular defense response	8.11	2.84e-04	1.29e-02	5/21	GNLY; ITGB1; PRF1; KLRG1; KLRC2
GO:0034113	heterotypic cell-cell adhesion	8.01	1.26e-03	3.28e-02	4/17	CD2; ITGA4; PERP; ITGB1
GO:0050866	negative regulation of cell activation	6.46	6.68e-07	1.22e-04	11/58	RUNX3; PTPN22; CD84; ID2; TIGIT; CD74; LST1; ANXA1; PRNP; TGFB1; SAMSN1
GO:0034341	response to interferon-gamma	6.15	1.11e-08	4.04e-06	15/83	TXK; HLA-DRA; HLA-DRB5; HLA-DRB1; HLA-DQA1; HLA-DQB1; HLA-DPA1; HLA-DPB1; IFNGR1; IFITM2; CASP1; CCL5; CCL3; CCL3L3; RPL13A
GO:0048144	fibroblast proliferation	5.49	1.87e-03	4.25e-02	5/31	JUN; S100A6; CD74; GSTP1; TGFB1
GO:0032609	interferon-gamma production	5.24	8.48e-04	2.47e-02	6/39	PTPN22; CD2; TXK; HLA-DPA1; HLA-DPB1; PRNP
GO:0033002	muscle cell proliferation	4.86	4.98e-04	1.65e-02	7/49	JUN; ID2; HPGD; GSTP1; PDCD4; CCL5; ERN1
GO:0060326	cell chemotaxis	4.54	5.66e-05	3.43e-03	10/75	CXCR6; CD74; CXCR3; ANXA1; GSTP1; JAML; CKLF; CCL5; CCL3; CCL3L3
GO:0070371	ERK1 and ERK2 cascade	4.48	6.35e-05	3.56e-03	10/76	JUN; PTPN22; SLAMF1; CD74; GSTP1; ZFP36L1; CCL5; CCL3; CCL3L3; TGFB1
GO:0045444	fat cell differentiation	4.04	1.55e-03	3.76e-02	7/59	ID2; GPX1; PLAC8; ARID5B; ZFP36L1; RORA; TGFB1
GO:0002694	regulation of leukocyte activation	3.96	9.23e-09	4.04e-06	23/198	RUNX3; PTPN22; CD2; CD84; ID2; DPP4; TIGIT; CD74; LST1; HLA-DPA1; HLA-DPB1; ANXA1; CD27; ZFP36L1; RORA; LAT; CCL5; IKZF3; PRNP; TMIGD2; TGFB1; LGALS1; SAMSN1
GO:0070661	leukocyte proliferation	3.86	5.36e-05	3.43e-03	12/106	PTPN22; CD74; LST1; HLA-DPA1; HLA-DPB1; ANXA1; GSTP1; CCL5; IKZF3; PRNP; TMIGD2; TGFB1
GO:0042110	T cell activation	3.77	2.39e-08	5.80e-06	23/208	RUNX3; PTPN22; CD2; CD8A; CD8B; DPP4; TIGIT; CD74; HLA-DPA1; HLA-DPB1; ANXA1; JAML; CD27; LCP1; ZFP36L1; RORA; LAT; CCL5; CD7; PRNP; TMIGD2; TGFB1; LGALS1
GO:0050673	epithelial cell proliferation	3.66	3.51e-04	1.42e-02	10/93	RUNX3; JUN; ID2; ITGA4; GPX1; JAML; ZFP36L1; CCL5; ERN1; TGFB1
GO:0050900	leukocyte migration	3.66	4.53e-05	3.43e-03	13/121	CD2; CD84; ITGA4; CD74; CXCR3; ANXA1; JAML; ITGB1; CKLF; CCL5; CCL3; CCL3L3; TGFB1
GO:0007159	leukocyte cell-cell adhesion	3.66	5.76e-06	8.32e-04	16/149	RUNX3; PTPN22; DPP4; ITGA4; TIGIT; CD74; HLA-DPA1; HLA-DPB1; ANXA1; ITGB1; CD27; CCL5; PRNP; TMIGD2; TGFB1; LGALS1
GO:0002250	adaptive immune response	3.61	6.86e-06	8.32e-04	16/151	CD84; SLAMF1; CD8A; CD8B; TXK; CD74; HLA-DQB1; ANXA1; PRF1; CD27; RORA; LAT; CD7; GZMM; TGFB1; SAMSN1
GO:0002237	response to molecule of bacterial origin	3.51	4.94e-04	1.65e-02	10/97	JUN; PTPN22; HPGD; GSTP1; CASP1; IL10RA; PDCD4; CCL5; CCL3; TGFB1
GO:0042113	B cell activation	3.50	2.64e-04	1.28e-02	11/107	ID2; ITGA4; CD74; ITM2A; ITGB1; CD27; ZFP36L1; IKZF3; TGFB1; LGALS1; SAMSN1
GO:0022407	regulation of cell-cell adhesion	3.34	3.45e-05	3.14e-03	15/153	RUNX3; PTPN22; DPP4; ITGA4; TIGIT; CD74; HLA-DPA1; HLA-DPB1; ANXA1; CD27; CCL5; PRNP; TMIGD2; TGFB1; LGALS1
GO:0019882	antigen processing and presentation	3.30	1.49e-03	3.75e-02	9/93	CD8A; CD74; HLA-DRA; HLA-DRB5; HLA-DRB1; HLA-DQA1; HLA-DQB1; HLA-DPA1; HLA-DPB1
GO:0002683	negative regulation of immune system process	3.23	5.04e-05	3.43e-03	15/158	RUNX3; PTPN22; CD84; ID2; GPX1; TIGIT; CD74; LST1; TSC22D3; ANXA1; ZFP36L1; CCL3; PRNP; TGFB1; SAMSN1
GO:0034612	response to tumor necrosis factor	3.23	1.73e-03	4.07e-02	9/95	LTB; GSTP1; CASP1; CD27; ZFP36L1; RORA; CCL5; CCL3; CCL3L3
GO:0050867	positive regulation of cell activation	3.10	4.40e-04	1.60e-02	12/132	RUNX3; CD2; DPP4; CD74; HLA-DPA1; HLA-DPB1; ANXA1; CD27; CCL5; TMIGD2; TGFB1; LGALS1
GO:0070972	protein localization to endoplasmic reticulum	3.07	8.21e-04	2.47e-02	11/122	RPS27A; RPSA; RPS18; RPL39; RPS20; RPS24; SRP14; RPS2; RPS15A; RPL13A; RPS5
GO:0002521	leukocyte differentiation	3.02	2.19e-05	2.27e-03	18/203	RUNX3; JUN; PTPN22; CD2; ID2; CD8A; ITGA4; CD74; ITM2A; ANXA1; ITGB1; CD27; ZFP36L1; RORA; CCL3; IKZF3; TGFB1; LGALS1
GO:0045785	positive regulation of cell adhesion	2.97	3.80e-04	1.46e-02	13/149	RUNX3; DPP4; ITGA4; CD74; HLA-DPA1; HLA-DPB1; ANXA1; SPOCK2; CD27; CCL5; TMIGD2; TGFB1; LGALS1
GO:0001525	angiogenesis	2.94	1.99e-03	4.39e-02	10/116	JUN; SH2D2A; GPX1; SAT1; CXCR3; ANXA1; ITGB1; ELK3; RORA; TMIGD2
GO:0001819	positive regulation of cytokine production	2.89	3.02e-04	1.29e-02	14/165	PTPN22; CD2; TIGIT; TXK; CD74; LTB; HLA-DPA1; HLA-DPB1; ANXA1; CASP1; RORA; CCL3; TMIGD2; TGFB1
GO:0051346	negative regulation of hydrolase activity	2.82	1.03e-03	2.88e-02	12/145	GPX1; GZMA; TNFAIP8; PTTG1; PHACTR2; PTPRN2; NGFRAP1; ANXA1; SYTL2; SPOCK2; CD27; GCHFR
GO:0019058	viral life cycle	2.78	1.16e-03	3.12e-02	12/147	SLAMF1; RPS27A; DPP4; RPSA; CXCR6; CD74; PABPC1; IFITM2; ITGB1; ISG20; CCL5; LGALS1
GO:0002764	immune response-regulating signaling pathway	2.47	6.75e-04	2.14e-02	16/221	JUN; PTPN22; RPS27A; TXK; FYB; NCR3; HLA-DRA; HLA-DRB5; HLA-DRB1; HLA-DQA1; HLA-DQB1; HLA-DPA1; HLA-DPB1; CALM1; LAT; PRNP

Factor 12 : 55 significant GO terms

GeneSet	description	enrichRatio	pValue	FDR	GeneRatio	geneSymbols
GO:0048013	ephrin receptor signaling pathway	13.80	5.94e-08	1.44e-05	8/30	CDC42; ARPC5; ACTR3; ARPC2; FYN; ACTB; ARPC1B; ACTG1
GO:1990868	response to chemokine	12.20	2.56e-04	7.17e-03	4/17	CXCR3; CCL5; CCL3L3; CCR7
GO:0034109	homotypic cell-cell adhesion	10.40	1.81e-05	7.74e-04	6/30	ACTB; ACTN1; CCL5; ACTG1; MYL12A; LGALS1
GO:0042116	macrophage activation	9.87	6.07e-04	1.38e-02	4/21	HAVCR2; AIF1; MFHAS1; RORA
GO:0046847	filopodium assembly	9.71	3.26e-03	4.56e-02	3/16	CAPZB; CDC42; CCR7
GO:0031529	ruffle organization	8.29	1.21e-03	2.26e-02	4/25	AIF1; PLEKHA1; PFN1; CCR7
GO:0097581	lamellipodium organization	7.85	3.74e-04	9.38e-03	5/33	CAPZB; CDC42; ARPC5; ARPC2; RAC2
GO:0060326	cell chemotaxis	7.60	1.38e-07	2.00e-05	11/75	LYST; LEF1; AIF1; TMSB4X; CXCR3; CORO1A; CCL5; CCL3L3; CCR7; RPS19; RAC2
GO:0007015	actin filament organization	7.51	2.71e-12	1.97e-09	19/131	CAPZB; CDC42; CAP1; ARPC5; TMSB10; CAPG; ACTR3; ARPC2; AIF1; ARPC1B; TMSB4X; CFL1; LCP1; ACTN1; CORO1A; PFN1; CCR7; TPM4; RAC2
GO:0070671	response to interleukin-12	7.40	4.96e-04	1.20e-02	5/35	CDC42; CFL1; RPLP0; LCP1; P4HB
GO:0008037	cell recognition	6.47	9.31e-04	1.79e-02	5/40	HAVCR2; CSGALNACT1; PRF1; CORO1A; CCR7
GO:0030101	natural killer cell activation	6.47	3.10e-03	4.52e-02	4/32	SLAMF7; ID2; HAVCR2; CORO1A
GO:0032970	regulation of actin filament-based process	6.37	7.27e-09	2.65e-06	15/122	CAPZB; CDC42; ARPC5; TMSB10; CAPG; ACTR3; ARPC2; ABRACL; ARPC1B; TMSB4X; CFL1; ARHGDIB; CORO1A; PFN1; CCR7
GO:0001906	cell killing	6.25	1.08e-04	3.57e-03	7/58	SLAMF7; LYST; HAVCR2; PRF1; B2M; CORO1A; RPS19
GO:0006909	phagocytosis	6.19	1.15e-06	1.05e-04	11/92	CDC42; ARPC5; ACTR3; ARPC2; LYAR; AIF1; FYN; ACTB; ARPC1B; CORO1A; ACTG1
GO:0051258	protein polymerization	5.75	2.71e-07	3.29e-05	13/117	CAPZB; ARPC5; TMSB10; CAPG; ACTR3; ARPC2; AIF1; ARPC1B; TMSB4X; RPS3; CORO1A; PFN1; CCR7
GO:0050808	synapse organization	5.68	6.90e-05	2.39e-03	8/73	CDC42; FYN; ACTB; LRRN3; CFL1; IL10RA; ACTN1; PFN1
GO:1902903	regulation of supramolecular fiber organization	5.66	1.10e-07	2.00e-05	14/128	CAPZB; CDC42; ARPC5; TMSB10; CAPG; ACTR3; ARPC2; ARPC1B; TMSB4X; CFL1; RPS3; CORO1A; PFN1; CCR7
GO:0031345	negative regulation of cell projection organization	5.63	1.77e-03	3.22e-02	5/46	CAPZB; FYN; VIM; B2M; LGALS1
GO:0034341	response to interferon-gamma	5.62	2.59e-05	9.90e-04	9/83	GBP1; ACTR3; AIF1; VIM; B2M; CCL5; CCL3L3; ACTG1; RPL13A
GO:0050803	regulation of synapse structure or activity	5.51	1.95e-03	3.30e-02	5/47	CDC42; FYN; LRRN3; CFL1; IL10RA
GO:0060491	regulation of cell projection assembly	5.41	2.71e-04	7.31e-03	7/67	CAPZB; CDC42; ARPC2; PFN1; CCR7; SEPT9; RAC2
GO:0031589	cell-substrate adhesion	5.12	5.43e-05	1.98e-03	9/91	CDC42; GBP1; ITGA4; ARPC2; ACTN1; CORO1A; CCR7; RAC2; LGALS1
GO:0050920	regulation of chemotaxis	4.89	3.33e-03	4.58e-02	5/53	AIF1; TMSB4X; CCL5; CCR7; RAC2
GO:0032103	positive regulation of response to external stimulus	4.82	2.22e-04	6.46e-03	8/86	HAVCR2; AIF1; TMSB4X; CCL5; CCL3L3; CCR7; RPS19; RAC2
GO:0090066	regulation of anatomical structure size	4.71	2.77e-06	2.02e-04	13/143	CAPZB; ARPC5; TMSB10; CAPG; ACTR3; ARPC2; ARPC1B; TMSB4X; CFL1; TMEM123; CORO1A; PFN1; CCR7
GO:0050900	leukocyte migration	4.71	1.72e-05	7.74e-04	11/121	LYST; ITGA4; AIF1; FYN; CXCR3; CORO1A; CCL5; CCL3L3; CCR7; RPS19; RAC2
GO:0002285	lymphocyte activation involved in immune response	4.65	6.93e-04	1.52e-02	7/78	LEF1; HAVCR2; ITM2A; LCP1; RORA; CORO1A; LGALS1
GO:0007159	leukocyte cell-cell adhesion	4.52	4.41e-06	2.51e-04	13/149	CDC42; ITGA4; TIGIT; HAVCR2; AIF1; FYN; RPS3; CORO1A; CCL5; CCR7; RAC2; LGALS1; GRAP2
GO:0043491	protein kinase B signaling	4.44	2.15e-03	3.48e-02	6/70	FYN; MFHAS1; PLEKHA1; CCL5; CCR7; RAC2
GO:0022407	regulation of cell-cell adhesion	4.40	5.92e-06	3.08e-04	13/153	CDC42; ITGA4; TIGIT; LEF1; HAVCR2; AIF1; FYN; RPS3; CORO1A; CCL5; CCR7; LGALS1; GRAP2
GO:0050817	coagulation	4.40	1.79e-04	5.67e-03	9/106	CAPZB; CDC42; FYN; ACTB; CD59; ENTPD1; ACTN1; ACTG1; MYL12A
GO:0042110	T cell activation	4.23	3.19e-07	3.32e-05	17/208	CDC42; TIGIT; LEF1; HAVCR2; AIF1; FYN; RPS3; LCP1; BCL11B; B2M; RORA; CORO1A; CCL5; CCR7; RAC2; LGALS1; GRAP2
GO:0045785	positive regulation of cell adhesion	4.17	2.40e-05	9.73e-04	12/149	CDC42; ITGA4; ARPC2; HAVCR2; AIF1; FYN; RPS3; CORO1A; CCL5; CCR7; LGALS1; GRAP2
GO:0070371	ERK1 and ERK2 cascade	4.09	3.26e-03	4.56e-02	6/76	GBP1; HAVCR2; MFHAS1; CCL5; CCL3L3; CCR7
GO:0051493	regulation of cytoskeleton organization	4.09	2.67e-06	2.02e-04	15/190	CAPZB; CDC42; ARPC5; TMSB10; CAPG; ACTR3; ARPC2; ARPC1B; TMSB4X; CFL1; RPS3; ARHGDIB; CORO1A; PFN1; CCR7
GO:0002449	lymphocyte mediated immunity	4.06	7.11e-04	1.52e-02	8/102	SLAMF7; LYST; HAVCR2; PRF1; KLRD1; KLRC2; B2M; CORO1A
GO:0007163	establishment or maintenance of cell polarity	4.04	3.48e-03	4.69e-02	6/77	CDC42; CAP1; ARPC5; ACTR3; CFL1; CCR7
GO:0050727	regulation of inflammatory response	3.98	8.10e-04	1.68e-02	8/104	TMSB4X; MFHAS1; CD59; RORA; CCL5; CCL3L3; CCR7; RPS19
GO:0002694	regulation of leukocyte activation	3.92	4.48e-06	2.51e-04	15/198	CDC42; ID2; TIGIT; HAVCR2; AIF1; FYN; MFHAS1; RPS3; RORA; CORO1A; CCL5; CCR7; RAC2; LGALS1; GRAP2
GO:0050867	positive regulation of cell activation	3.92	2.00e-04	6.08e-03	10/132	CDC42; HAVCR2; AIF1; FYN; RPS3; CORO1A; CCL5; CCR7; LGALS1; GRAP2
GO:0070661	leukocyte proliferation	3.91	9.18e-04	1.79e-02	8/106	LEF1; HAVCR2; AIF1; FYN; RPS3; CORO1A; CCL5; RAC2
GO:0070972	protein localization to endoplasmic reticulum	3.82	5.16e-04	1.21e-02	9/122	RPL12; RPS3; RPS26; RPL41; RPLP0; RPS15A; RPS19; RPL13A; RPL3
GO:0034612	response to tumor necrosis factor	3.82	2.22e-03	3.52e-02	7/95	GBP1; LTB; TMSB4X; RPS3; RORA; CCL5; CCL3L3
GO:0002764	immune response-regulating signaling pathway	3.75	3.75e-06	2.48e-04	16/221	CDC42; GBP1; ARPC5; ACTR3; ARPC2; FYB; HAVCR2; FYN; ACTB; ARPC1B; MFHAS1; RPS3; PLEKHA1; CCR7; ACTG1; GRAP2
GO:0002237	response to molecule of bacterial origin	3.74	2.50e-03	3.88e-02	7/97	HAVCR2; IL10RA; VIM; PTGER2; B2M; CCL5; CCR7
GO:0050878	regulation of body fluid levels	3.67	3.43e-04	8.93e-03	10/141	CAPZB; CDC42; FYN; ACTB; AQP3; CD59; ENTPD1; ACTN1; ACTG1; MYL12A
GO:0043254	regulation of protein complex assembly	3.65	1.10e-05	5.33e-04	15/213	CAPZB; CDC42; ARPC5; TMSB10; CAPG; ACTR3; ARPC2; ARPC1B; TMSB4X; RPS3; LCP1; CORO1A; PFN1; CCR7; RPL13A
GO:0048871	multicellular organismal homeostasis	3.51	1.84e-03	3.27e-02	8/118	PASK; PLAC8; ACTB; AQP3; B2M; CORO1A; ACTG1; RAC2
GO:0031346	positive regulation of cell projection organization	3.49	3.71e-03	4.91e-02	7/104	CDC42; ARPC2; FYN; PFN1; CCR7; SEPT9; RAC2
GO:0035690	cellular response to drug	3.48	1.95e-03	3.30e-02	8/119	AIF1; FYN; ACTB; RPS3; VIM; DDIT4; PLEKHA1; HNRNPA1
GO:0072507	divalent inorganic cation homeostasis	3.31	2.65e-03	3.94e-02	8/125	FYN; CXCR3; TPT1; LPAR6; PTGER2; CORO1A; CCL5; CCR7
GO:0006413	translational initiation	3.24	9.34e-04	1.79e-02	10/160	RPL12; RPS3; RPS26; RPL41; RPLP0; RPS15A; CCL5; RPS19; RPL13A; RPL3
GO:0009615	response to virus	3.13	2.15e-03	3.48e-02	9/149	GBP1; LYST; CFL1; PRF1; DDIT4; TPT1; NPC2; RPS15A; CCL5
GO:2000147	positive regulation of cell motility	3.05	2.58e-03	3.91e-02	9/153	ITGA4; LEF1; AIF1; TMSB4X; CORO1A; PFN1; CCL5; CCR7; RAC2

Factor 13 : 61 significant GO terms

GeneSet	description	enrichRatio	pValue	FDR	GeneRatio	geneSymbols
GO:1990868	response to chemokine	13.20	2.53e-05	1.02e-03	5/17	CXCR4; CCL3; CCL3L3; CCL4L2; CCR7
GO:0050918	positive chemotaxis	11.20	2.06e-03	3.08e-02	3/12	HMGB1; LGALS3; CCL3
GO:0002437	inflammatory response to antigenic stimulus	10.50	4.47e-04	1.02e-02	4/17	FCER1G; HLA-E; HMGB1; CCR7
GO:0019233	sensory perception of pain	10.30	2.63e-03	3.68e-02	3/13	F2R; P2RX4; CCL3
GO:0060326	cell chemotaxis	9.56	3.65e-12	1.65e-09	16/75	NBL1; FCER1G; LYST; CXCR4; ITGA1; CD74; TMSB4X; JAML; P2RX4; HMGB1; LGALS3; CCL3; CCL3L3; CCL4L2; CCR7; ITGB2
GO:0006968	cellular defense response	8.53	1.05e-03	1.91e-02	4/21	SH2D1A; PRF1; KLRG1; KLRC2
GO:0098742	cell-cell adhesion via plasma-membrane adhesion molecules	8.53	1.05e-03	1.91e-02	4/21	SELL; EMB; JAML; ITGB2
GO:0002449	lymphocyte mediated immunity	7.90	4.53e-12	1.65e-09	18/102	TNFRSF1B; SLAMF7; FCER1G; LYST; CD96; CD74; HLA-E; HLA-DQB1; SH2D1A; CTSC; CRTAM; PRF1; CD27; LAG3; KLRC2; HMGB1; GZMB; CD226
GO:0001906	cell killing	7.72	4.35e-07	2.87e-05	10/58	SLAMF7; LYST; HLA-E; SH2D1A; CTSC; CRTAM; PRF1; LAG3; GZMB; CD226
GO:0032612	interleukin-1 production	7.72	3.92e-04	9.21e-03	5/29	IFI16; F2R; HMGB1; CCL3; CCR7
GO:0007229	integrin-mediated signaling pathway	7.68	1.04e-04	3.14e-03	6/35	FCER1G; PLEK; ITGA1; TIMP1; ITGB7; ITGB2
GO:0050920	regulation of chemotaxis	7.61	1.94e-06	9.41e-05	9/53	NBL1; CXCR4; CD74; TMSB4X; P2RX4; HMGB1; CCL3; CCL4L2; CCR7
GO:0034341	response to interferon-gamma	7.56	2.44e-09	3.56e-07	14/83	HLA-E; HLA-DRA; HLA-DRB5; HLA-DRB1; HLA-DQA1; HLA-DQB1; HLA-DPA1; HLA-DPB1; IFITM2; VIM; EVL; CCL3; CCL3L3; CCL4L2
GO:0031529	ruffle organization	7.17	2.07e-03	3.08e-02	4/25	PLEK; P2RX4; EVL; CCR7
GO:0030101	natural killer cell activation	7.00	6.31e-04	1.35e-02	5/32	ZNF683; SLAMF7; ID2; HLA-E; ITGB2
GO:0032609	interferon-gamma production	6.89	1.94e-04	5.42e-03	6/39	CD96; HLA-DPA1; HLA-DPB1; HMGB1; CCR7; CD226
GO:0006959	humoral immune response	6.79	7.30e-04	1.52e-02	5/33	HLA-E; HLA-DQB1; SH2D1A; CD81; CCR7
GO:0008037	cell recognition	6.72	2.24e-04	6.03e-03	6/40	EMB; CRTAM; PRF1; LGALS3; CCR7; CD226
GO:0050900	leukocyte migration	6.66	9.05e-11	2.20e-08	18/121	NBL1; FCER1G; SELL; LYST; SOS1; CXCR4; ITGA1; CD74; JAML; ITGB7; P2RX4; HMGB1; LGALS3; CCL3; CCL3L3; CCL4L2; CCR7; ITGB2
GO:1903034	regulation of response to wounding	6.64	2.78e-03	3.82e-02	4/27	FCER1G; PLEK; F2R; HMGB1
GO:0002526	acute inflammatory response	6.40	3.19e-03	4.30e-02	4/28	FCER1G; HLA-E; CD81; CCR7
GO:0019882	antigen processing and presentation	6.26	9.83e-08	8.93e-06	13/93	FCER1G; CD74; HLA-E; HLA-DRA; HLA-DRB5; HLA-DRB1; HLA-DQA1; HLA-DQB1; HLA-DMB; HLA-DPA1; HLA-DPB1; LAG3; CCR7
GO:0032103	positive regulation of response to external stimulus	5.73	2.51e-06	1.14e-04	11/86	FCER1G; CD74; HLA-E; TMSB4X; P2RX4; HMGB1; CCL3; CCL3L3; CCL4L2; CCR7; ITGB2
GO:0050663	cytokine secretion	5.51	8.39e-05	2.91e-03	8/65	TNFRSF1B; F2R; TMSB4X; CRTAM; SRGN; HMGB1; CCL3; CCR7
GO:0070661	leukocyte proliferation	5.49	4.73e-07	2.87e-05	13/106	TNFRSF1B; SOS1; CD74; HLA-E; HLA-DMB; HLA-DPA1; HLA-DPB1; CD81; CRTAM; HMGB1; LGALS3; IKZF3; TMIGD2
GO:0002576	platelet degranulation	5.21	2.48e-03	3.54e-02	5/43	FCER1G; PLEK; TMSB4X; TIMP1; SRGN
GO:0007159	leukocyte cell-cell adhesion	5.11	2.07e-08	2.16e-06	17/149	SELL; TIGIT; CD74; HLA-E; HLA-DMB; HLA-DPA1; HLA-DPB1; NT5E; CD27; LAG3; ITGB7; HMGB1; LGALS3; CCR7; TMIGD2; LGALS1; ITGB2
GO:0050867	positive regulation of cell activation	5.09	1.61e-07	1.17e-05	15/132	FCER1G; PLEK; CD74; HLA-E; HLA-DMB; HLA-DPA1; HLA-DPB1; CD81; CD27; HMGB1; CCR7; CD226; TMIGD2; LGALS1; ITGB2
GO:0002694	regulation of leukocyte activation	4.98	2.14e-10	3.89e-08	22/198	TNFRSF1B; ZNF683; FCER1G; ID2; SOS1; TIGIT; CD74; HLA-E; HLA-DMB; HLA-DPA1; HLA-DPB1; CD81; CD27; LAG3; HMGB1; LGALS3; IKZF3; CCR7; CD226; TMIGD2; LGALS1; ITGB2
GO:0043270	positive regulation of ion transport	4.98	1.17e-03	2.07e-02	6/54	F2R; TMSB4X; P2RX4; LGALS3; CCL3; CCL4L2
GO:0002697	regulation of immune effector process	4.88	1.10e-07	8.93e-06	16/147	TNFRSF1B; ZNF683; FCER1G; CD96; CD74; HLA-E; HLA-DMB; SH2D1A; CD81; CRTAM; LAG3; HMGB1; LGALS3; CD226; APOBEC3G; ITGB2
GO:0031345	negative regulation of cell projection organization	4.87	3.35e-03	4.43e-02	5/46	ODF2L; ITM2C; VIM; EVL; LGALS1
GO:0043062	extracellular structure organization	4.72	1.55e-03	2.51e-02	6/57	TNFRSF1B; CAPG; ITGA1; TIMP1; ITGB7; ITGB2
GO:0071887	leukocyte apoptotic process	4.67	4.04e-03	4.91e-02	5/48	FCER1G; CD74; CD27; LGALS3; CCR7
GO:0050866	negative regulation of cell activation	4.63	1.70e-03	2.69e-02	6/58	ID2; TIGIT; CD74; LAG3; HMGB1; LGALS3
GO:0002440	production of molecular mediator of immune response	4.48	3.65e-04	8.86e-03	8/80	TNFRSF1B; FCER1G; CD96; CD74; HLA-E; HLA-DQB1; CD226; TMIGD2
GO:0002250	adaptive immune response	4.45	9.48e-07	5.31e-05	15/151	TNFRSF1B; ZNF683; SLAMF7; FCER1G; CD74; HLA-E; HLA-DQB1; SH2D1A; CTSC; CRTAM; PRF1; CD27; HMGB1; CD7; CD226
GO:0042110	T cell activation	4.31	2.02e-08	2.16e-06	20/208	TNFRSF1B; ZNF683; FCER1G; SOS1; TIGIT; CD74; HLA-E; HLA-DMB; HLA-DPA1; HLA-DPB1; JAML; CRTAM; CD27; LAG3; HMGB1; LGALS3; CCR7; CD7; TMIGD2; LGALS1
GO:0050727	regulation of inflammatory response	4.31	9.21e-05	3.05e-03	10/104	TNFRSF1B; FCER1G; HLA-E; NT5E; TMSB4X; CD81; CCL3; CCL3L3; CCR7; ITGB2
GO:0043087	regulation of GTPase activity	4.14	1.05e-06	5.48e-05	16/173	S100A10; RGS1; SOS1; LIMS1; ARHGAP15; RASA2; ARAP2; F2R; ARHGAP18; PTPRN2; ARHGEF12; RGS10; CCL3; CCL3L3; CCL4L2; CCR7
GO:0070371	ERK1 and ERK2 cascade	4.13	1.41e-03	2.38e-02	7/76	F2R; CD74; HMGB1; CCL3; CCL3L3; CCL4L2; CCR7
GO:0031589	cell-substrate adhesion	3.94	8.73e-04	1.67e-02	8/91	S100A10; LIMS1; CD96; ITGA1; ITGB7; CCR7; LGALS1; ITGB2
GO:0022407	regulation of cell-cell adhesion	3.81	2.95e-05	1.13e-03	13/153	TIGIT; CD74; HLA-E; HLA-DMB; HLA-DPA1; HLA-DPB1; CD27; LAG3; HMGB1; LGALS3; CCR7; TMIGD2; LGALS1
GO:0001819	positive regulation of cytokine production	3.80	1.45e-05	6.20e-04	14/165	IFI16; FCER1G; TIGIT; F2R; CD74; HLA-E; HLA-DPA1; HLA-DPB1; CRTAM; HMGB1; CCL3; CCR7; CD226; TMIGD2
GO:0002237	response to molecule of bacterial origin	3.69	1.33e-03	2.30e-02	8/97	TNFRSF1B; CD96; F2R; VIM; HMGB1; LITAF; CCL3; CCR7
GO:0045785	positive regulation of cell adhesion	3.61	1.03e-04	3.14e-03	12/149	S100A10; LIMS1; CD74; HLA-E; HLA-DMB; HLA-DPA1; HLA-DPB1; CD27; HMGB1; CCR7; TMIGD2; LGALS1
GO:0031349	positive regulation of defense response	3.57	5.77e-05	2.10e-03	13/163	PYHIN1; IFI16; FCER1G; HLA-E; SH2D1A; CRTAM; LAG3; HMGB1; CCL3; CCL3L3; CCR7; CD226; ITGB2
GO:0090066	regulation of anatomical structure size	3.45	3.05e-04	7.92e-03	11/143	PLEK; CAPG; ITGA1; F2R; ARHGAP18; TMSB4X; ARPC5L; TMEM123; EVL; CCR7; DSTN
GO:0002683	negative regulation of immune system process	3.40	1.81e-04	5.26e-03	12/158	NBL1; IFI16; FCER1G; ID2; CD96; TIGIT; CD74; HLA-E; LAG3; HMGB1; LGALS3; CCL3
GO:0032970	regulation of actin filament-based process	3.30	1.48e-03	2.44e-02	9/122	S100A10; PLEK; CAPG; ARHGAP18; TMSB4X; ARPC5L; EVL; CCR7; DSTN
GO:0002791	regulation of peptide secretion	3.29	8.25e-04	1.62e-02	10/136	TNFRSF1B; F2R; CD74; HLA-E; TMSB4X; CRTAM; SRGN; HMGB1; CCL3; CCR7
GO:0051235	maintenance of location	3.17	3.51e-03	4.56e-02	8/113	NBL1; F2R; SYNE1; TMSB4X; SRGN; CCL3; CCR7; FTL
GO:1902903	regulation of supramolecular fiber organization	3.15	2.07e-03	3.08e-02	9/128	S100A10; PLEK; CAPG; ARHGAP18; TMSB4X; ARPC5L; EVL; CCR7; DSTN
GO:0001667	ameboidal-type cell migration	3.14	3.70e-03	4.73e-02	8/114	ZEB2; TMSB4X; TIMP1; ITGB7; P2RX4; HMGB1; EVL; ITGB2
GO:0045088	regulation of innate immune response	3.10	7.55e-04	1.53e-02	11/159	PYHIN1; IFI16; FCER1G; CD96; HLA-E; SH2D1A; CRTAM; LAG3; HMGB1; CD226; ITGB2
GO:0051047	positive regulation of secretion	3.09	4.12e-03	4.91e-02	8/116	FCER1G; F2R; HLA-E; CRTAM; P2RX4; HMGB1; CCL3; ITGB2
GO:0072511	divalent inorganic cation transport	3.09	4.12e-03	4.91e-02	8/116	F2R; AHNAK; ATP2B1; P2RX4; LGALS3; CCL3; CCL4L2; CCR7
GO:0007015	actin filament organization	3.08	2.42e-03	3.53e-02	9/131	S100A10; PLEK; CAPG; ARHGAP18; TMSB4X; ARPC5L; EVL; CCR7; DSTN
GO:0002521	leukocyte differentiation	2.87	5.22e-04	1.15e-02	13/203	ZNF683; IFI16; FCER1G; ID2; SOS1; CD74; CD27; HMGB1; LGALS3; CCL3; IKZF3; CCR7; LGALS1
GO:0002764	immune response-regulating signaling pathway	2.84	3.52e-04	8.82e-03	14/221	FCER1G; SOS1; HLA-DRA; HLA-DRB5; HLA-DRB1; HLA-DQA1; HLA-DQB1; HLA-DPA1; HLA-DPB1; HMGB1; LGALS3; CCR7; CD226; ITGB2
GO:1903706	regulation of hemopoiesis	2.67	4.02e-03	4.91e-02	10/168	ZNF683; ID2; SOS1; CD74; CD27; HMGB1; LGALS3; CCL3; IKZF3; LGALS1

Factor 14 : 15 significant GO terms

GeneSet	description	enrichRatio	pValue	FDR	GeneRatio	geneSymbols
GO:0097327	response to antineoplastic agent	6.91	6.72e-04	0.03548	5/33	CFLAR; DDIT4; HNRNPA1; PCNA; RPL18A
GO:0038061	NIK/NF-kappaB signaling	6.76	1.86e-05	0.00489	8/54	PRDX1; HAVCR2; BIRC3; NFKB2; CD27; NFKBIA; CYLD; RELB
GO:0031099	regeneration	5.59	6.28e-04	0.03548	6/49	CFLAR; NINJ1; LCP1; PKM; TYMS; PCNA
GO:0032606	type I interferon production	4.77	5.91e-04	0.03548	7/67	IFIH1; STAT1; HMGB2; HAVCR2; NFKB2; CYLD; RELB
GO:0007249	I-kappaB kinase/NF-kappaB signaling	4.71	2.84e-06	0.00207	13/126	S100A4; TANK; STAT1; CFLAR; CD74; TNIP1; SQSTM1; HSPB1; PIM2; BIRC3; OPTN; NFKBIA; RELB
GO:0002181	cytoplasmic translation	4.50	8.41e-04	0.04079	7/71	RPL15; RPL39; RPS26; RPL6; RPLP1; RPS21; RPL18A
GO:0070972	protein localization to endoplasmic reticulum	3.74	3.00e-04	0.02424	10/122	RPL15; RPS18; RPL39; RPLP2; RPS26; RPL6; RPLP1; RPS21; RPL18A; RPS9
GO:0045088	regulation of innate immune response	3.73	3.66e-05	0.00666	13/159	TANK; IFIH1; STAT1; HMGB2; TNIP1; HAVCR2; BIRC3; PTPN6; NFKBIA; CYLD; SEC14L1; RELB; ITGB2
GO:0031349	positive regulation of defense response	3.64	4.75e-05	0.00692	13/163	TANK; IFIH1; HMGB2; TNIP1; HAVCR2; SLC25A6; BIRC3; OPTN; NFKBIA; CYLD; SEC14L1; RELB; ITGB2
GO:0098542	defense response to other organism	3.55	1.19e-04	0.01440	12/154	LYST; IFIH1; STAT1; HMGB2; HAVCR2; RPL39; BIRC3; OPTN; DDIT4; SEC14L1; IL27RA; APOBEC3G
GO:0001819	positive regulation of cytokine production	3.32	2.29e-04	0.02081	12/165	IFIH1; STAT1; HMGB2; CD74; HAVCR2; LTB; HSPB1; BIRC3; NFKB2; HIF1A; SEC14L1; IL27RA
GO:0002764	immune response-regulating signaling pathway	3.30	2.02e-05	0.00489	16/221	TANK; IFIH1; FYB; TNIP1; HAVCR2; HLA-DRA; HLA-DQA1; ARPC1B; PHPT1; BIRC3; PTPN6; NFKBIA; CYLD; SEC14L1; RELB; ITGB2
GO:0006413	translational initiation	3.14	6.82e-04	0.03548	11/160	RPL15; RPS18; HSPB1; RPL39; RPLP2; RPS26; RPL6; RPLP1; RPS21; RPL18A; RPS9
GO:1902532	negative regulation of intracellular signal transduction	3.03	1.79e-04	0.01858	14/211	STMN1; TANK; STAT1; CD74; TNIP1; HSPB1; DNAJA1; CD44; OPTN; DDIT4; PTPN6; HIF1A; CYLD; SEC14L1
GO:0090150	establishment of protein localization to membrane	2.89	4.80e-04	0.03494	13/205	RPL15; RPS18; NCF1; RPL39; RPLP2; OPTN; RPS26; RPL6; RPLP1; RPS21; RPL18A; RPS9; ITGB2

Factor 16 : 33 significant GO terms

GeneSet	description	enrichRatio	pValue	FDR	GeneRatio	geneSymbols
GO:0046939	nucleotide phosphorylation	28.30	4.20e-14	2.66e-11	11/43	ENO1; PGK1; LDHA; PFKP; DDIT4; PGAM1; GAPDH; TPI1; PKM; ALDOA; ALDOC
GO:0006090	pyruvate metabolic process	27.00	7.31e-14	2.66e-11	11/45	ENO1; PGK1; LDHA; PFKP; DDIT4; PGAM1; GAPDH; TPI1; PKM; ALDOA; ALDOC
GO:0009132	nucleoside diphosphate metabolic process	23.80	3.30e-13	8.01e-11	11/51	ENO1; PGK1; LDHA; PFKP; DDIT4; PGAM1; GAPDH; TPI1; PKM; ALDOA; ALDOC
GO:0016052	carbohydrate catabolic process	21.30	1.23e-12	2.24e-10	11/57	ENO1; PGK1; LDHA; PFKP; DDIT4; PGAM1; GAPDH; TPI1; PKM; ALDOA; ALDOC
GO:0072524	pyridine-containing compound metabolic process	18.70	5.68e-12	8.27e-10	11/65	ENO1; PGK1; LDHA; PFKP; DDIT4; PGAM1; GAPDH; TPI1; PKM; ALDOA; ALDOC
GO:0046434	organophosphate catabolic process	15.80	3.93e-11	3.57e-09	11/77	ENO1; PGK1; LDHA; PFKP; DDIT4; PGAM1; GAPDH; TPI1; PKM; ALDOA; ALDOC
GO:0034404	nucleobase-containing small molecule biosynthetic process	14.30	1.19e-10	9.64e-09	11/85	ENO1; PGK1; LDHA; PFKP; DDIT4; PGAM1; GAPDH; TPI1; PKM; ALDOA; ALDOC
GO:0046390	ribose phosphate biosynthetic process	11.90	2.08e-11	2.52e-09	13/121	ENO1; TMSB4X; PGK1; LDHA; ATP5L; PFKP; DDIT4; PGAM1; GAPDH; TPI1; PKM; ALDOA; ALDOC
GO:0072522	purine-containing compound biosynthetic process	11.40	3.50e-11	3.57e-09	13/126	ENO1; TMSB4X; PGK1; LDHA; ATP5L; PFKP; DDIT4; PGAM1; GAPDH; TPI1; PKM; ALDOA; ALDOC
GO:0016053	organic acid biosynthetic process	11.00	3.30e-10	2.40e-08	12/120	ENO1; PGK1; LDHA; PFKP; DDIT4; PGAM1; GAPDH; TPI1; PKM; ALDOA; ALDOC; MIF
GO:0016051	carbohydrate biosynthetic process	11.00	2.40e-06	8.73e-05	7/70	ENO1; PGK1; PGAM1; GAPDH; TPI1; ALDOA; ALDOC
GO:0005996	monosaccharide metabolic process	10.70	9.65e-08	4.39e-06	9/93	ENO1; PGK1; PFKP; PGAM1; GAPDH; TPI1; PKM; ALDOA; ALDOC
GO:0051188	cofactor biosynthetic process	10.30	4.33e-09	2.63e-07	11/118	ENO1; PGK1; LDHA; PFKP; DDIT4; PGAM1; GAPDH; TPI1; PKM; ALDOA; ALDOC
GO:1901293	nucleoside phosphate biosynthetic process	9.45	3.83e-10	2.53e-08	13/152	ENO1; TMSB4X; PGK1; LDHA; ATP5L; PFKP; DDIT4; PGAM1; GAPDH; TPI1; PKM; ALDOA; ALDOC
GO:0006732	coenzyme metabolic process	8.50	3.33e-08	1.62e-06	11/143	ENO1; PGK1; LDHA; PFKP; DDIT4; PGAM1; GAPDH; TPI1; PKM; ALDOA; ALDOC
GO:0050663	cytokine secretion	8.50	2.67e-04	8.44e-03	5/65	HSPD1; TMSB4X; GAPDH; CCR7; MIF
GO:0070482	response to oxygen levels	8.18	2.22e-07	8.49e-06	10/135	ENO1; RPS27A; HSPD1; FAM162A; PGK1; LDHA; DDIT4; BNIP3; PKM; TCEB2
GO:0009141	nucleoside triphosphate metabolic process	7.68	5.05e-09	2.83e-07	13/187	ENO1; TMSB4X; PGK1; LDHA; ATP5L; PFKP; DDIT4; PGAM1; GAPDH; TPI1; PKM; ALDOA; ALDOC
GO:0009123	nucleoside monophosphate metabolic process	7.25	1.02e-08	5.29e-07	13/198	ENO1; TMSB4X; PGK1; LDHA; ATP5L; PFKP; DDIT4; PGAM1; GAPDH; TPI1; PKM; ALDOA; ALDOC
GO:0044282	small molecule catabolic process	6.95	3.84e-06	1.33e-04	9/143	ENO1; PGK1; PFKP; PGAM1; GAPDH; TPI1; PKM; ALDOA; ALDOC
GO:0034341	response to interferon-gamma	6.66	8.31e-04	2.16e-02	5/83	IFITM2; VIM; GAPDH; ACTG1; RPL13A
GO:0007015	actin filament organization	5.90	1.48e-04	4.89e-03	7/131	S100A10; TMSB10; TMSB4X; CFL1; ALDOA; PFN1; CCR7
GO:0006091	generation of precursor metabolites and energy	5.89	1.25e-07	5.34e-06	13/244	ENO1; PGK1; LDHA; ATP5L; PFKP; DDIT4; PGAM1; BNIP3; GAPDH; TPI1; PKM; ALDOA; ALDOC
GO:0009259	ribonucleotide metabolic process	5.77	1.58e-07	6.41e-06	13/249	ENO1; TMSB4X; PGK1; LDHA; ATP5L; PFKP; DDIT4; PGAM1; GAPDH; TPI1; PKM; ALDOA; ALDOC
GO:0032970	regulation of actin filament-based process	5.43	7.18e-04	2.01e-02	6/122	S100A10; TMSB10; TMSB4X; CFL1; PFN1; CCR7
GO:0070972	protein localization to endoplasmic reticulum	5.43	7.18e-04	2.01e-02	6/122	RPS27A; RPS18; RPS24; RPS15; RPL13A; RPL3
GO:1902903	regulation of supramolecular fiber organization	5.18	9.25e-04	2.32e-02	6/128	S100A10; TMSB10; TMSB4X; CFL1; PFN1; CCR7
GO:0002791	regulation of peptide secretion	4.87	1.27e-03	3.08e-02	6/136	HSPD1; SLC25A6; TMSB4X; GAPDH; CCR7; MIF
GO:0006413	translational initiation	4.83	5.07e-04	1.54e-02	7/160	RPS27A; NPM1; RPS18; RPS24; RPS15; RPL13A; RPL3
GO:0010639	negative regulation of organelle organization	4.47	8.11e-04	2.16e-02	7/173	H3F3A; TMSB10; NPM1; TMSB4X; BNIP3; HNRNPA1; PFN1
GO:0051493	regulation of cytoskeleton organization	4.07	1.41e-03	3.31e-02	7/190	S100A10; TMSB10; NPM1; TMSB4X; CFL1; PFN1; CCR7
GO:0006401	RNA catabolic process	3.54	1.56e-03	3.54e-02	8/250	RPS27A; NPM1; RPS18; VIM; RPS24; RPS15; RPL13A; RPL3
GO:0006605	protein targeting	3.41	1.95e-03	4.30e-02	8/259	RPS27A; HSPD1; RPS18; SLC25A6; RPS24; RPS15; RPL13A; RPL3

Factor 17 : 12 significant GO terms

GeneSet	description	enrichRatio	pValue	FDR	GeneRatio	geneSymbols
GO:0070972	protein localization to endoplasmic reticulum	11.20	0.00e+00	0.00e+00	45/122	RPL11; RPS8; RPS27; RPL31; RPL37A; RPL32; RPSA; RPL14; RPL29; RPL35A; RPL9; RPL34; RPS3A; RPL37; RPS23; RPS18; RPS12; RPS4X; RPL36A; RPL39; RPL10; RPL30; RPL12; RPLP2; RPL27A; RPS13; RPS25; RPL41; RPL21; RPS29; RPS17; RPS2; RPS15A; RPL13; RPL26; RPL23A; RPL23; RPL27; RPL38; RPS28; RPL18A; RPS16; KDELR1; RPS9; RPL28
GO:0002181	cytoplasmic translation	11.10	0.00e+00	0.00e+00	26/71	RPL11; DPH5; RPL31; RPL32; RPL29; RPL35A; RPL9; RPS23; EIF2S3; RPL36A; RPL39; RPL30; EIF3E; EIF3H; EIF3F; EIF3M; RPL41; RPS29; RPL26; RPL38; EEF2; RPS28; EIF3G; RPL18A; EIF3K; EIF3D
GO:0006413	translational initiation	10.80	0.00e+00	0.00e+00	57/160	RPL11; RPS8; RPS27; RPL31; RPL37A; RPL32; RPSA; RPL14; RPL29; EIF2A; RPL35A; RPL9; RPL34; RPS3A; RPL37; RPS23; NPM1; RPS18; RPS12; EIF2S3; RPS4X; RPL36A; RPL39; RPL10; RPL30; PABPC1; EIF3E; EIF3H; RPL12; RPLP2; EIF3F; RPL27A; RPS13; EIF3M; RPS25; RPL41; RPL21; RPS29; RPS17; RPS2; RPS15A; RPL13; RPL26; RPL23A; RPL23; EIF1; RPL27; RPL38; RPS28; EIF3G; RPL18A; EIF3K; RPS16; RPS9; RPL28; EIF3D; ATF4
GO:0090150	establishment of protein localization to membrane	6.80	0.00e+00	0.00e+00	46/205	RPL11; RPS8; RPS27; SSR2; RPL31; RPL37A; RPL32; RPSA; RPL14; RPL29; RPL35A; RPL9; RPL34; RPS3A; RPL37; RPS23; GNB2L1; RPS18; RPS12; RPS4X; RPL36A; RPL39; RPL10; RPL30; RPL12; RPLP2; RPL27A; RPS13; RPS25; RPL41; RPL21; RPS29; RPS17; RPS2; RPS15A; RPL13; RPL26; RPL23A; RPL23; RPL27; RPL38; RPS28; RPL18A; RPS16; RPS9; RPL28
GO:0006401	RNA catabolic process	6.31	0.00e+00	0.00e+00	52/250	RPL11; RPS8; RPS27; RPL31; RPL37A; RPL32; RPSA; RPL14; RPL29; FXR1; RPL35A; RPL9; RPL34; RPS3A; RPL37; RPS23; NPM1; LSM2; RPS18; RPS12; RPS4X; RPL36A; RPL39; RPL10; RPL30; PABPC1; EIF3E; RPL12; RPLP2; RPL27A; RPS13; RPS25; HSPA8; VIM; RPL41; RPL21; APEX1; RPS29; RPS17; RPS2; RPS15A; RPL13; RPL26; RPL23A; RPL23; RPL27; RPL38; RPS28; RPL18A; RPS16; RPS9; RPL28
GO:0006605	protein targeting	5.85	0.00e+00	0.00e+00	50/259	RPL11; RPS8; RPS27; SSR2; RPL31; HSPD1; RPL37A; RPL32; RPSA; RPL14; RPL29; RPL35A; RPL9; RPL34; RPS3A; RPL37; RPS23; RPS18; RPS12; PMPCB; SLC25A6; RPS4X; RPL36A; RPL39; RPL10; RPL30; RPL12; RPLP2; RPL27A; RPS13; RPS25; HSPA8; RPL41; RPL21; RPS29; RPS17; RPS2; RPS15A; UQCRC2; RPL13; RPL26; RPL23A; RPL23; RPL27; RPL38; RPS28; RPL18A; RPS16; RPS9; RPL28
GO:0034341	response to interferon-gamma	4.02	7.41e-05	4.91e-03	11/83	HLA-E; AIF1; HLA-DRA; HLA-DPB1; HSP90AB1; ZYX; CD44; VIM; GAPDH; B2M; ACTG1
GO:0071826	ribonucleoprotein complex subunit organization	3.67	4.03e-08	3.67e-06	23/190	RPL11; RPS27; RPSA; EIF2A; RPS23; NPM1; HSP90AB1; EIF2S3; RPL10; ZFAND1; EIF3E; EIF3H; RPL12; EIF3F; EIF3M; RSL24D1; RPL23A; ZNHIT3; RPL38; RPS28; EIF3G; EIF3K; EIF3D
GO:0034248	regulation of cellular amide metabolic process	3.07	1.07e-06	8.63e-05	23/227	DPH5; BIN1; PASK; EIF2A; FXR1; NPM1; GNB2L1; RBM3; RPS4X; RPL10; PABPC1; EIF3E; EIF3H; VIM; GAPDH; RPL26; EIF1; RPL38; EEF2; EIF3K; RPS9; EIF3D; ATF4
GO:0022613	ribonucleoprotein complex biogenesis	3.01	2.90e-09	3.02e-07	34/342	RPL11; RPS8; RPS27; RPSA; RPL14; EIF2A; RPL35A; LYAR; RPS23; NPM1; HSP90AB1; EIF2S3; RPL10; EIF3E; EIF3H; RPL12; EIF3F; EIF3M; RSL24D1; RPS17; RPS2; NOB1; RPL26; RPL23A; ZNHIT3; RPL27; MRPL10; RPL38; RPS28; EIF3G; EIF3K; RPS16; RPS9; EIF3D
GO:0016072	rRNA metabolic process	2.74	2.06e-04	1.25e-02	16/177	RPL11; RPS8; RPS27; RPSA; RPL14; RPL35A; LYAR; RPS17; RPS2; NOB1; RPL26; ZNHIT3; RPL27; RPS28; RPS16; RPS9
GO:0010608	posttranscriptional regulation of gene expression	2.44	3.39e-05	2.47e-03	24/298	DPH5; PASK; EIF2A; FXR1; NPM1; GNB2L1; RBM3; RPS4X; RPL10; PABPC1; EIF3E; EIF3H; HSPA8; VIM; GAPDH; APEX1; RPL26; EIF1; RPL38; EEF2; EIF3K; RPS9; EIF3D; ATF4

Factor 18 : 34 significant GO terms

GeneSet	description	enrichRatio	pValue	FDR	GeneRatio	geneSymbols
GO:0050918	positive chemotaxis	17.80	5.37e-04	0.017767	3/12	LGALS3; CORO1A; CCL5
GO:0070670	response to interleukin-4	14.20	1.47e-04	0.011245	4/20	TCF7; HSPA5; CORO1A; XBP1
GO:0060191	regulation of lipase activity	11.80	1.87e-03	0.043635	3/18	RHOC; ANXA1; CCL5
GO:0043270	positive regulation of ion transport	7.89	9.51e-05	0.011245	6/54	FLNA; TRIAP1; LGALS3; CALM1; CCL5; BAX
GO:0071887	leukocyte apoptotic process	7.40	5.13e-04	0.017767	5/48	ANXA1; CD27; LGALS3; CCL5; BAX
GO:0001906	cell killing	7.35	1.43e-04	0.011245	6/58	GNLY; GAPDH; GZMB; CORO1A; GZMM; RPS19
GO:0060326	cell chemotaxis	6.63	7.51e-05	0.011245	7/75	ITGA1; CXCR3; ANXA1; LGALS3; CORO1A; CCL5; RPS19
GO:0035821	modification of morphology or physiology of other organism	6.56	2.69e-04	0.012248	6/65	GNLY; GAPDH; CALM1; PPIB; CCL5; RPS19
GO:0009410	response to xenobiotic stimulus	5.55	1.92e-03	0.043635	5/64	HSPA5; DDIT4; MDM2; CALM1; PCNA
GO:0010959	regulation of metal ion transport	5.46	2.56e-04	0.012248	7/91	FLNA; AHNAK; LGALS3; CALM1; CORO1A; CCL5; BAX
GO:0050900	leukocyte migration	5.28	4.14e-05	0.010054	9/121	ITGA1; MYO1G; CXCR3; DOK2; ANXA1; LGALS3; CORO1A; CCL5; RPS19
GO:2000147	positive regulation of cell motility	5.11	7.40e-06	0.002693	11/153	RHOC; FLNA; ANXA1; HSPA5; PHPT1; MDM2; LGALS3; CORO1A; PFN1; CCL5; XBP1
GO:0051235	maintenance of location	5.03	1.62e-04	0.011245	8/113	FLNA; HSPA5; SRGN; HSP90B1; CALM1; CORO1A; BAX; FTL
GO:0002449	lymphocyte mediated immunity	4.87	5.17e-04	0.017767	7/102	MYO1G; CD27; KLRD1; KLRC2; GZMB; CORO1A; GZMM
GO:0061458	reproductive system development	4.82	2.19e-04	0.012248	8/118	TCF7; PRDM1; FLNA; ANXA1; HSPA5; ZFP36L1; SPINT2; BAX
GO:0042110	T cell activation	4.78	7.88e-07	0.000573	14/208	ZNF683; SATB1; TCF7; PRDM1; ANXA1; CD27; LGALS3; ZFP36L1; LAT; CORO1A; CCL5; CD7; BAX; XBP1
GO:0034765	regulation of ion transmembrane transport	4.74	1.54e-03	0.039497	6/90	CLIC1; FLNA; AHNAK; CALM1; CORO1A; BAX
GO:0104004	cellular response to environmental stimulus	4.60	1.23e-04	0.011245	9/139	XPC; HSPA5; DDB2; MDM2; TRIAP1; ZFP36L1; CALM1; PCNA; BAX
GO:0051346	negative regulation of hydrolase activity	4.41	1.70e-04	0.011245	9/145	GZMA; ANXA1; CD27; GAPDH; MDM2; TRIAP1; LGALS3; CDKN2D; SPINT2
GO:0072511	divalent inorganic cation transport	4.29	1.12e-03	0.034874	7/116	AHNAK; TPT1; LGALS3; CALM1; CORO1A; CCL5; BAX
GO:0052547	regulation of peptidase activity	4.18	2.55e-04	0.012248	9/153	CD27; GAPDH; MDM2; TRIAP1; RPS27L; CDKN2D; SPINT2; BBC3; BAX
GO:0097193	intrinsic apoptotic signaling pathway	4.10	2.95e-04	0.012650	9/156	DDIT4; MDM2; TRIAP1; TPT1; RPS27L; CDKN2D; BBC3; BAX; XBP1
GO:0009314	response to radiation	4.06	1.43e-04	0.011245	10/175	XPC; ANXA1; HSPA5; DDB2; MDM2; TRIAP1; CALM1; PCNA; CDKN2D; BAX
GO:0044843	cell cycle G1/S phase transition	4.04	1.57e-03	0.039497	7/123	ANXA1; MDM2; TRIAP1; RPS27L; PCNA; CDKN2D; BAX
GO:0045930	negative regulation of mitotic cell cycle	4.04	1.57e-03	0.039497	7/123	XPC; MDM2; TRIAP1; ZFP36L1; RPS27L; PCNA; BAX
GO:0048872	homeostasis of number of cells	4.04	1.57e-03	0.039497	7/123	LYAR; ANXA1; ZFP36L1; LAT; CORO1A; RPS19; BAX
GO:0072507	divalent inorganic cation homeostasis	3.98	1.73e-03	0.041922	7/125	CXCR3; HSP90B1; TPT1; CALM1; CORO1A; CCL5; BAX
GO:2001233	regulation of apoptotic signaling pathway	3.88	2.07e-04	0.012248	10/183	MDM2; TRIAP1; TPT1; GZMB; LGALS3; PDIA3; CDKN2D; BBC3; BAX; XBP1
GO:0070997	neuron death	3.85	2.07e-03	0.044346	7/129	ITGA1; HSPA5; DDIT4; GAPDH; CORO1A; CCL5; BAX
GO:0002250	adaptive immune response	3.76	1.15e-03	0.034874	8/151	ZNF683; PRDM1; MYO1G; ANXA1; CD27; LAT; CD7; GZMM
GO:0031667	response to nutrient levels	3.60	1.54e-03	0.039497	8/158	AQP3; HSPA5; NUCB2; MDM2; HSP90B1; PCNA; CDKN2D; XBP1
GO:0002694	regulation of leukocyte activation	3.59	3.93e-04	0.015887	10/198	ZNF683; PRDM1; ANXA1; CD27; LGALS3; ZFP36L1; LAT; CORO1A; CCL5; XBP1
GO:0002521	leukocyte differentiation	3.50	4.79e-04	0.017767	10/203	ZNF683; SATB1; TCF7; PRDM1; ANXA1; CD27; LGALS3; ZFP36L1; BAX; XBP1
GO:1901987	regulation of cell cycle phase transition	3.13	2.04e-03	0.044346	9/204	XPC; ANXA1; MDM2; TRIAP1; ZFP36L1; RPS27L; PCNA; CDKN2D; BAX

Factor 19 : 7 significant GO terms

GeneSet	description	enrichRatio	pValue	FDR	GeneRatio	geneSymbols
GO:0019882	antigen processing and presentation	26.70	8.02e-12	5.84e-09	9/93	CD74; HLA-DRA; HLA-DRB5; HLA-DRB1; HLA-DQA1; HLA-DQB1; HLA-DMB; HLA-DPA1; HLA-DPB1
GO:0034341	response to interferon-gamma	26.60	1.64e-10	5.96e-08	8/83	HLA-DRA; HLA-DRB5; HLA-DRB1; HLA-DQA1; HLA-DQB1; HLA-DPA1; HLA-DPB1; CCL4L2
GO:0006959	humoral immune response	25.10	2.03e-04	2.47e-02	3/33	GNLY; HLA-DQB1; RPS19
GO:0070661	leukocyte proliferation	13.00	2.75e-05	5.01e-03	5/106	CD74; HLA-DMB; HLA-DPA1; HLA-DPB1; IKZF3
GO:0002449	lymphocyte mediated immunity	10.80	4.10e-04	4.26e-02	4/102	CD74; HLA-DQB1; KLRD1; GZMB
GO:0002764	immune response-regulating signaling pathway	8.75	6.53e-06	1.58e-03	7/221	HLA-DRA; HLA-DRB5; HLA-DRB1; HLA-DQA1; HLA-DQB1; HLA-DPA1; HLA-DPB1
GO:0002694	regulation of leukocyte activation	8.37	4.60e-05	6.69e-03	6/198	ID2; CD74; HLA-DMB; HLA-DPA1; HLA-DPB1; IKZF3

Factor 20 : 8 significant GO terms

GeneSet	description	enrichRatio	pValue	FDR	GeneRatio	geneSymbols
GO:0070972	protein localization to endoplasmic reticulum	16.10	0.00e+00	0.00e+00	30/122	RPS8; RPS27; RPL31; RPL15; RPL14; RPL35A; RPL34; RPS3A; RPS14; RPS4X; RPL10; RPL30; RPS6; RPL12; RPL27A; RPS25; RPS24; RPS26; RPL41; RPLP0; RPS29; RPL4; RPLP1; RPL23A; RPL38; RPS21; RPS15; RPL36; RPS28; RPL28
GO:0002181	cytoplasmic translation	13.80	6.44e-14	7.81e-12	15/71	RPL31; RPL15; TMA7; RPL35A; RPL30; RPS26; RPL41; RPLP0; RPS29; RPLP1; RPL38; RPS21; EEF2; RPL36; RPS28
GO:0006413	translational initiation	12.70	0.00e+00	0.00e+00	31/160	RPS8; RPS27; RPL31; RPL15; RPL14; RPL35A; RPL34; RPS3A; RPS14; RPS4X; RPL10; RPL30; PABPC1; RPS6; RPL12; RPL27A; RPS25; RPS24; RPS26; RPL41; RPLP0; RPS29; RPL4; RPLP1; RPL23A; RPL38; RPS21; RPS15; RPL36; RPS28; RPL28
GO:0090150	establishment of protein localization to membrane	9.89	0.00e+00	0.00e+00	31/205	RPS8; RPS27; RPL31; RPL15; RPL14; RPL35A; RPL34; RPS3A; RPS14; RPS4X; RPL10; RPL30; RPS6; RPL12; RPL27A; RPS25; RPS24; RPS26; RPL41; RPLP0; GZMB; RPS29; RPL4; RPLP1; RPL23A; RPL38; RPS21; RPS15; RPL36; RPS28; RPL28
GO:0006401	RNA catabolic process	8.37	0.00e+00	0.00e+00	32/250	RPS8; RPS27; RPL31; RPL15; RPL14; RPL35A; RPL34; RPS3A; RPS14; RPS4X; RPL10; RPL30; PABPC1; RPS6; RPL12; RPL27A; RPS25; VIM; RPS24; RPS26; RPL41; RPLP0; RPS29; RPL4; RPLP1; RPL23A; RPL38; RPS21; RPS15; RPL36; RPS28; RPL28
GO:0006605	protein targeting	8.08	0.00e+00	0.00e+00	32/259	RPS8; RPS27; RPL31; RPL15; RPL14; RPL35A; RPL34; RPS3A; RPS14; TOMM7; RPS4X; RPL10; RPL30; RPS6; RPL12; RPL27A; RPS25; RPS24; RPS26; RPL41; RPLP0; RPS29; RPL4; RPLP1; RPL23A; RPL38; RPS21; RPS15; RPL36; RPS28; RPL28; TSPO
GO:0016072	rRNA metabolic process	3.70	3.15e-04	2.87e-02	10/177	RPS8; RPS27; RPL14; RPL35A; RPS14; RPS6; RPS24; RPS21; RPS15; RPS28
GO:0022613	ribonucleoprotein complex biogenesis	2.87	1.60e-04	1.67e-02	15/342	RPS8; RPS27; RPL14; RPL35A; RPS14; RPL10; RPS6; RPL12; RPS24; RPLP0; RPL23A; RPL38; RPS21; RPS15; RPS28

Summary:
Factor	1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	19	20
Signif_GO_terms	93	45	91	0	14	61	29	23	13	54	33	55	61	15	0	33	12	34	7	8

3.1.1 Factors of interest

Immune response:
3, 6, 10, 11, 12, 13, 18, 19

Cell cycle:
7, 18

From the reference study:

Targeting CD5, RASA2, SOCS1, and CBLB promoted programs that are characterized by the induction of markers of activation states (e.g. IL2RA, TNFRSF18/GITR), cell cycle genes (e.g. MKI67, UBE2S, CENPF and TOP2A), and effector molecules (e.g GZMB).

Associated factors in GSFA:

RASA2: 10, 12, 16
CDKN1B: 2

From the reference study:

Targeting CD3D or LCP2 inhibited the cluster 10 activation program and promoted programs characterized by expression of resting state markers such as IL7R and CCR7.

Associated factors in GSFA

3.2 Reactome Pathway Over-Representation Analysis

Gene sets: The Reactome pathway database.

Factor 1 : 54 significant Reactome pathways

GeneSet	description	enrichRatio	pValue	FDR	GeneRatio	geneSymbols
R-HSA-156902	Peptide chain elongation	8.33	0.00e+00	0.00e+00	62/84	RPL22; RPL11; RPS8; RPL5; RPS27; RPS7; RPS27A; RPL31; RPL32; RPL15; RPL14; RPL29; RPL24; RPL35A; RPL9; RPL34; RPS3A; RPL37; RPS23; RPS14; RPL10A; EEF1A1; RPS12; RPL10; RPS20; RPL7; RPL30; RPS6; RPL7A; RPLP2; RPL27A; RPS13; RPS25; RPS24; RPL41; RPL6; RPL21; RPS29; RPS27L; RPL4; RPLP1; RPS17; RPS15A; RPL13; RPL26; RPL23A; RPL23; RPL19; RPL27; RPL38; RPS21; EEF2; RPL36; RPS28; RPL18A; UBA52; RPS16; RPS19; RPL18; RPL13A; RPS11; RPS5
R-HSA-156842	Eukaryotic Translation Elongation	8.17	0.00e+00	0.00e+00	63/87	RPL22; RPL11; RPS8; RPL5; RPS27; RPS7; RPS27A; RPL31; EEF1B2; RPL32; RPL15; RPL14; RPL29; RPL24; RPL35A; RPL9; RPL34; RPS3A; RPL37; RPS23; RPS14; RPL10A; EEF1A1; RPS12; RPL10; RPS20; RPL7; RPL30; RPS6; RPL7A; RPLP2; RPL27A; RPS13; RPS25; RPS24; RPL41; RPL6; RPL21; RPS29; RPS27L; RPL4; RPLP1; RPS17; RPS15A; RPL13; RPL26; RPL23A; RPL23; RPL19; RPL27; RPL38; RPS21; EEF2; RPL36; RPS28; RPL18A; UBA52; RPS16; RPS19; RPL18; RPL13A; RPS11; RPS5
R-HSA-192823	Viral mRNA Translation	8.06	0.00e+00	0.00e+00	60/84	RPL22; RPL11; RPS8; RPL5; RPS27; RPS7; RPS27A; RPL31; RPL32; RPL15; RPL14; RPL29; RPL24; RPL35A; RPL9; RPL34; RPS3A; RPL37; RPS23; RPS14; RPL10A; RPS12; RPL10; RPS20; RPL7; RPL30; RPS6; RPL7A; RPLP2; RPL27A; RPS13; RPS25; RPS24; RPL41; RPL6; RPL21; RPS29; RPS27L; RPL4; RPLP1; RPS17; RPS15A; RPL13; RPL26; RPL23A; RPL23; RPL19; RPL27; RPL38; RPS21; RPL36; RPS28; RPL18A; UBA52; RPS16; RPS19; RPL18; RPL13A; RPS11; RPS5
R-HSA-2408557	Selenocysteine synthesis	7.96	0.00e+00	0.00e+00	60/85	RPL22; RPL11; RPS8; RPL5; RPS27; RPS7; RPS27A; RPL31; RPL32; RPL15; RPL14; RPL29; RPL24; RPL35A; RPL9; RPL34; RPS3A; RPL37; RPS23; RPS14; RPL10A; RPS12; RPL10; RPS20; RPL7; RPL30; RPS6; RPL7A; RPLP2; RPL27A; RPS13; RPS25; RPS24; RPL41; RPL6; RPL21; RPS29; RPS27L; RPL4; RPLP1; RPS17; RPS15A; RPL13; RPL26; RPL23A; RPL23; RPL19; RPL27; RPL38; RPS21; RPL36; RPS28; RPL18A; UBA52; RPS16; RPS19; RPL18; RPL13A; RPS11; RPS5
R-HSA-975956	Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)	7.82	0.00e+00	0.00e+00	61/88	RPL22; RPL11; RPS8; RPL5; RPS27; RPS7; RPS27A; RPL31; RPL32; RPL15; RPL14; RPL29; RPL24; RPL35A; RPL9; RPL34; RPS3A; RPL37; RPS23; RPS14; RPL10A; RPS12; RPL10; RPS20; RPL7; RPL30; PABPC1; RPS6; RPL7A; RPLP2; RPL27A; RPS13; RPS25; RPS24; RPL41; RPL6; RPL21; RPS29; RPS27L; RPL4; RPLP1; RPS17; RPS15A; RPL13; RPL26; RPL23A; RPL23; RPL19; RPL27; RPL38; RPS21; RPL36; RPS28; RPL18A; UBA52; RPS16; RPS19; RPL18; RPL13A; RPS11; RPS5
R-HSA-72764	Eukaryotic Translation Termination	7.78	0.00e+00	0.00e+00	60/87	RPL22; RPL11; RPS8; RPL5; RPS27; RPS7; RPS27A; RPL31; RPL32; RPL15; RPL14; RPL29; RPL24; RPL35A; RPL9; RPL34; RPS3A; RPL37; RPS23; RPS14; RPL10A; RPS12; RPL10; RPS20; RPL7; RPL30; RPS6; RPL7A; RPLP2; RPL27A; RPS13; RPS25; RPS24; RPL41; RPL6; RPL21; RPS29; RPS27L; RPL4; RPLP1; RPS17; RPS15A; RPL13; RPL26; RPL23A; RPL23; RPL19; RPL27; RPL38; RPS21; RPL36; RPS28; RPL18A; UBA52; RPS16; RPS19; RPL18; RPL13A; RPS11; RPS5
R-HSA-72689	Formation of a pool of free 40S subunits	7.48	0.00e+00	0.00e+00	63/95	RPL22; RPL11; RPS8; RPL5; RPS27; RPS7; RPS27A; RPL31; RPL32; RPL15; RPL14; RPL29; RPL24; RPL35A; RPL9; RPL34; RPS3A; RPL37; RPS23; RPS14; RPL10A; RPS12; RPL10; RPS20; RPL7; RPL30; EIF3E; EIF3H; RPS6; RPL7A; RPLP2; RPL27A; RPS13; RPS25; RPS24; RPL41; RPL6; RPL21; RPS29; RPS27L; RPL4; RPLP1; RPS17; RPS15A; RPL13; RPL26; RPL23A; RPL23; RPL19; RPL27; RPL38; RPS21; RPL36; RPS28; RPL18A; UBA52; RPS16; RPS19; RPL18; RPL13A; RPS11; RPS5; EIF3L
R-HSA-156827	L13a-mediated translational silencing of Ceruloplasmin expression	6.98	0.00e+00	0.00e+00	65/105	RPL22; RPL11; RPS8; RPL5; RPS27; RPS7; RPS27A; RPL31; RPL32; RPL15; RPL14; RPL29; RPL24; RPL35A; RPL9; RPL34; RPS3A; RPL37; RPS23; RPS14; RPL10A; RPS12; EIF2S3; RPL10; RPS20; RPL7; RPL30; PABPC1; EIF3E; EIF3H; RPS6; RPL7A; RPLP2; RPL27A; RPS13; RPS25; RPS24; RPL41; RPL6; RPL21; RPS29; RPS27L; RPL4; RPLP1; RPS17; RPS15A; RPL13; RPL26; RPL23A; RPL23; RPL19; RPL27; RPL38; RPS21; RPL36; RPS28; RPL18A; UBA52; RPS16; RPS19; RPL18; RPL13A; RPS11; RPS5; EIF3L
R-HSA-2408522	Selenoamino acid metabolism	6.84	0.00e+00	0.00e+00	60/99	RPL22; RPL11; RPS8; RPL5; RPS27; RPS7; RPS27A; RPL31; RPL32; RPL15; RPL14; RPL29; RPL24; RPL35A; RPL9; RPL34; RPS3A; RPL37; RPS23; RPS14; RPL10A; RPS12; RPL10; RPS20; RPL7; RPL30; RPS6; RPL7A; RPLP2; RPL27A; RPS13; RPS25; RPS24; RPL41; RPL6; RPL21; RPS29; RPS27L; RPL4; RPLP1; RPS17; RPS15A; RPL13; RPL26; RPL23A; RPL23; RPL19; RPL27; RPL38; RPS21; RPL36; RPS28; RPL18A; UBA52; RPS16; RPS19; RPL18; RPL13A; RPS11; RPS5
R-HSA-72706	GTP hydrolysis and joining of the 60S ribosomal subunit	6.81	0.00e+00	0.00e+00	64/106	RPL22; RPL11; RPS8; RPL5; RPS27; RPS7; RPS27A; RPL31; RPL32; RPL15; RPL14; RPL29; RPL24; RPL35A; RPL9; RPL34; RPS3A; RPL37; RPS23; RPS14; RPL10A; RPS12; EIF2S3; RPL10; RPS20; RPL7; RPL30; EIF3E; EIF3H; RPS6; RPL7A; RPLP2; RPL27A; RPS13; RPS25; RPS24; RPL41; RPL6; RPL21; RPS29; RPS27L; RPL4; RPLP1; RPS17; RPS15A; RPL13; RPL26; RPL23A; RPL23; RPL19; RPL27; RPL38; RPS21; RPL36; RPS28; RPL18A; UBA52; RPS16; RPS19; RPL18; RPL13A; RPS11; RPS5; EIF3L
R-HSA-1799339	SRP-dependent cotranslational protein targeting to membrane	6.60	0.00e+00	0.00e+00	62/106	RPL22; RPL11; RPS8; RPL5; RPS27; RPS7; RPS27A; RPL31; RPL32; RPL15; RPL14; RPL29; RPL24; RPL35A; RPL9; RPL34; RPS3A; RPL37; RPS23; RPS14; RPL10A; RPS12; RPL10; RPS20; RPL7; RPL30; RPS6; RPL7A; RPLP2; RPL27A; RPS13; RPS25; RPS24; RPL41; RPL6; RPL21; RPS29; SRP14; RPS27L; RPL4; RPLP1; RPS17; RPS15A; RPL13; RPL26; RPL23A; RPL23; RPL19; RPL27; RPL38; SEC11C; RPS21; RPL36; RPS28; RPL18A; UBA52; RPS16; RPS19; RPL18; RPL13A; RPS11; RPS5
R-HSA-375276	Peptide ligand-binding receptors	6.58	2.16e-05	4.36e-04	7/12	UTS2; CXCR4; CXCR6; F2R; ANXA1; CCL5; CCR7
R-HSA-927802	Nonsense-Mediated Decay (NMD)	6.55	0.00e+00	0.00e+00	61/105	RPL22; RPL11; RPS8; RPL5; RPS27; RPS7; RPS27A; RPL31; RPL32; RPL15; RPL14; RPL29; RPL24; RPL35A; RPL9; RPL34; RPS3A; RPL37; RPS23; RPS14; RPL10A; RPS12; RPL10; RPS20; RPL7; RPL30; PABPC1; RPS6; RPL7A; RPLP2; RPL27A; RPS13; RPS25; RPS24; RPL41; RPL6; RPL21; RPS29; RPS27L; RPL4; RPLP1; RPS17; RPS15A; RPL13; RPL26; RPL23A; RPL23; RPL19; RPL27; RPL38; RPS21; RPL36; RPS28; RPL18A; UBA52; RPS16; RPS19; RPL18; RPL13A; RPS11; RPS5
R-HSA-975957	Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)	6.55	0.00e+00	0.00e+00	61/105	RPL22; RPL11; RPS8; RPL5; RPS27; RPS7; RPS27A; RPL31; RPL32; RPL15; RPL14; RPL29; RPL24; RPL35A; RPL9; RPL34; RPS3A; RPL37; RPS23; RPS14; RPL10A; RPS12; RPL10; RPS20; RPL7; RPL30; PABPC1; RPS6; RPL7A; RPLP2; RPL27A; RPS13; RPS25; RPS24; RPL41; RPL6; RPL21; RPS29; RPS27L; RPL4; RPLP1; RPS17; RPS15A; RPL13; RPL26; RPL23A; RPL23; RPL19; RPL27; RPL38; RPS21; RPL36; RPS28; RPL18A; UBA52; RPS16; RPS19; RPL18; RPL13A; RPS11; RPS5
R-HSA-72613	Eukaryotic Translation Initiation	6.55	0.00e+00	0.00e+00	65/112	RPL22; RPL11; RPS8; RPL5; RPS27; RPS7; RPS27A; RPL31; RPL32; RPL15; RPL14; RPL29; RPL24; RPL35A; RPL9; RPL34; RPS3A; RPL37; RPS23; RPS14; RPL10A; RPS12; EIF2S3; RPL10; RPS20; RPL7; RPL30; PABPC1; EIF3E; EIF3H; RPS6; RPL7A; RPLP2; RPL27A; RPS13; RPS25; RPS24; RPL41; RPL6; RPL21; RPS29; RPS27L; RPL4; RPLP1; RPS17; RPS15A; RPL13; RPL26; RPL23A; RPL23; RPL19; RPL27; RPL38; RPS21; RPL36; RPS28; RPL18A; UBA52; RPS16; RPS19; RPL18; RPL13A; RPS11; RPS5; EIF3L
R-HSA-72737	Cap-dependent Translation Initiation	6.55	0.00e+00	0.00e+00	65/112	RPL22; RPL11; RPS8; RPL5; RPS27; RPS7; RPS27A; RPL31; RPL32; RPL15; RPL14; RPL29; RPL24; RPL35A; RPL9; RPL34; RPS3A; RPL37; RPS23; RPS14; RPL10A; RPS12; EIF2S3; RPL10; RPS20; RPL7; RPL30; PABPC1; EIF3E; EIF3H; RPS6; RPL7A; RPLP2; RPL27A; RPS13; RPS25; RPS24; RPL41; RPL6; RPL21; RPS29; RPS27L; RPL4; RPLP1; RPS17; RPS15A; RPL13; RPL26; RPL23A; RPL23; RPL19; RPL27; RPL38; RPS21; RPL36; RPS28; RPL18A; UBA52; RPS16; RPS19; RPL18; RPL13A; RPS11; RPS5; EIF3L
R-HSA-202430	Translocation of ZAP-70 to Immunological synapse	6.45	6.54e-06	1.45e-04	8/14	PTPN22; HLA-DRA; HLA-DRB5; HLA-DRB1; HLA-DQA1; HLA-DQB1; HLA-DPA1; HLA-DPB1
R-HSA-72695	Formation of the ternary complex, and subsequently, the 43S complex	6.35	0.00e+00	0.00e+00	27/48	RPS8; RPS27; RPS7; RPS27A; RPS3A; RPS23; RPS14; RPS12; EIF2S3; RPS20; EIF3E; EIF3H; RPS6; RPS13; RPS25; RPS24; RPS29; RPS27L; RPS17; RPS15A; RPS21; RPS28; RPS16; RPS19; RPS11; RPS5; EIF3L
R-HSA-6783783	Interleukin-10 signaling	6.08	4.33e-05	8.16e-04	7/13	TNFRSF1B; CCL5; CCL3; CCL4; CCL3L3; CCL4L2
R-HSA-202427	Phosphorylation of CD3 and TCR zeta chains	5.97	3.89e-06	8.87e-05	9/17	PTPN22; PTPRC; HLA-DRA; HLA-DRB5; HLA-DRB1; HLA-DQA1; HLA-DQB1; HLA-DPA1; HLA-DPB1
R-HSA-72649	Translation initiation complex formation	5.74	4.44e-16	1.28e-14	28/55	RPS8; RPS27; RPS7; RPS27A; RPS3A; RPS23; RPS14; RPS12; EIF2S3; RPS20; PABPC1; EIF3E; EIF3H; RPS6; RPS13; RPS25; RPS24; RPS29; RPS27L; RPS17; RPS15A; RPS21; RPS28; RPS16; RPS19; RPS11; RPS5; EIF3L
R-HSA-168273	Influenza Viral RNA Transcription and Replication	5.69	0.00e+00	0.00e+00	60/119	RPL22; RPL11; RPS8; RPL5; RPS27; RPS7; RPS27A; RPL31; RPL32; RPL15; RPL14; RPL29; RPL24; RPL35A; RPL9; RPL34; RPS3A; RPL37; RPS23; RPS14; RPL10A; RPS12; RPL10; RPS20; RPL7; RPL30; RPS6; RPL7A; RPLP2; RPL27A; RPS13; RPS25; RPS24; RPL41; RPL6; RPL21; RPS29; RPS27L; RPL4; RPLP1; RPS17; RPS15A; RPL13; RPL26; RPL23A; RPL23; RPL19; RPL27; RPL38; RPS21; RPL36; RPS28; RPL18A; UBA52; RPS16; RPS19; RPL18; RPL13A; RPS11; RPS5
R-HSA-72662	Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S	5.64	8.88e-16	2.48e-14	28/56	RPS8; RPS27; RPS7; RPS27A; RPS3A; RPS23; RPS14; RPS12; EIF2S3; RPS20; PABPC1; EIF3E; EIF3H; RPS6; RPS13; RPS25; RPS24; RPS29; RPS27L; RPS17; RPS15A; RPS21; RPS28; RPS16; RPS19; RPS11; RPS5; EIF3L
R-HSA-72702	Ribosomal scanning and start codon recognition	5.54	5.33e-15	1.44e-13	27/55	RPS8; RPS27; RPS7; RPS27A; RPS3A; RPS23; RPS14; RPS12; EIF2S3; RPS20; EIF3E; EIF3H; RPS6; RPS13; RPS25; RPS24; RPS29; RPS27L; RPS17; RPS15A; RPS21; RPS28; RPS16; RPS19; RPS11; RPS5; EIF3L
R-HSA-373755	Semaphorin interactions	5.40	1.15e-06	2.93e-05	11/23	RHOC; PTPRC; ITGA1; HSP90AB1; FYN; TLN1; CFL1; ARHGEF12; ITGB1; MYL6; ARHGAP35
R-HSA-168255	Influenza Life Cycle	5.29	0.00e+00	0.00e+00	60/128	RPL22; RPL11; RPS8; RPL5; RPS27; RPS7; RPS27A; RPL31; RPL32; RPL15; RPL14; RPL29; RPL24; RPL35A; RPL9; RPL34; RPS3A; RPL37; RPS23; RPS14; RPL10A; RPS12; RPL10; RPS20; RPL7; RPL30; RPS6; RPL7A; RPLP2; RPL27A; RPS13; RPS25; RPS24; RPL41; RPL6; RPL21; RPS29; RPS27L; RPL4; RPLP1; RPS17; RPS15A; RPL13; RPL26; RPL23A; RPL23; RPL19; RPL27; RPL38; RPS21; RPL36; RPS28; RPL18A; UBA52; RPS16; RPS19; RPL18; RPL13A; RPS11; RPS5
R-HSA-389948	PD-1 signaling	5.27	1.39e-04	2.56e-03	7/15	HLA-DRA; HLA-DRB5; HLA-DRB1; HLA-DQA1; HLA-DQB1; HLA-DPA1; HLA-DPB1
R-HSA-373076	Class A/1 (Rhodopsin-like receptors)	5.17	1.96e-06	4.58e-05	11/24	UTS2; CXCR4; CXCR6; PTGER4; F2R; ANXA1; LPAR6; GPR183; GPR68; CCL5; CCR7
R-HSA-373753	Nephrin family interactions	5.13	1.56e-03	2.51e-02	5/11	SPTBN1; FYN; ACTN1; IQGAP1; ACTN4
R-HSA-168254	Influenza Infection	5.11	0.00e+00	0.00e+00	62/137	RPL22; RPL11; RPS8; RPL5; RPS27; RPS7; EIF2AK2; RPS27A; RPL31; RPL32; RPL15; RPL14; RPL29; RPL24; RPL35A; RPL9; RPL34; RPS3A; RPL37; RPS23; RPS14; RPL10A; RPS12; SLC25A6; RPL10; RPS20; RPL7; RPL30; RPS6; RPL7A; RPLP2; RPL27A; RPS13; RPS25; RPS24; RPL41; RPL6; RPL21; RPS29; RPS27L; RPL4; RPLP1; RPS17; RPS15A; RPL13; RPL26; RPL23A; RPL23; RPL19; RPL27; RPL38; RPS21; RPL36; RPS28; RPL18A; UBA52; RPS16; RPS19; RPL18; RPL13A; RPS11; RPS5
R-HSA-216083	Integrin cell surface interactions	4.84	7.53e-04	1.25e-02	6/14	ITGA4; ITGA1; CD44; ITGB1; ICAM2; PECAM1
R-HSA-9010553	Regulation of expression of SLITs and ROBOs	4.76	0.00e+00	0.00e+00	62/147	RPL22; RPL11; RPS8; RPL5; RPS27; RPS7; RPS27A; RPL31; RPL32; RPL15; RPL14; RPL29; RPL24; RPL35A; RPL9; RPL34; RPS3A; RPL37; RPS23; RPS14; RPL10A; RPS12; RPL10; RPS20; RPL7; RPL30; PABPC1; RPS6; RPL7A; RPLP2; RPL27A; RPS13; RPS25; RPS24; RPL41; RPL6; UBC; RPL21; RPS29; RPS27L; RPL4; RPLP1; RPS17; RPS15A; RPL13; RPL26; RPL23A; RPL23; RPL19; RPL27; RPL38; RPS21; RPL36; RPS28; RPL18A; UBA52; RPS16; RPS19; RPL18; RPL13A; RPS11; RPS5
R-HSA-5663084	Diseases of carbohydrate metabolism	4.70	2.49e-03	3.85e-02	5/12	RPS27A; GYG1; IDS; UBC; UBA52
R-HSA-6791226	Major pathway of rRNA processing in the nucleolus and cytosol	4.56	0.00e+00	0.00e+00	61/151	RPL22; RPL11; RPS8; RPL5; RPS27; RPS7; RPS27A; RPL31; RPL32; RPL15; RPL14; RPL29; RPL24; RPL35A; RPL9; RPL34; RPS3A; RPL37; RPS23; RPS14; RPL10A; RPS12; RPL10; RPS20; RPL7; RPL30; RPS6; RPL7A; RPLP2; RPL27A; RPS13; RPS25; DDX21; RPS24; RPL41; RPL6; RPL21; RPS29; RPS27L; RPL4; RPLP1; RPS17; RPS15A; RPL13; RPL26; RPL23A; RPL23; RPL19; RPL27; RPL38; RPS21; RPL36; RPS28; RPL18A; UBA52; RPS16; RPS19; RPL18; RPL13A; RPS11; RPS5
R-HSA-198933	Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell	4.46	4.25e-08	1.12e-06	17/43	SLAMF7; SELL; CD8A; ITGA4; NCR3; CD99; CD81; JAML; ITGB1; KLRG1; KLRB1; CLEC2B; KLRD1; KLRC1; B2M; ICAM2; HCST
R-HSA-376176	Signaling by ROBO receptors	4.32	0.00e+00	0.00e+00	64/167	RPL22; RPL11; RPS8; RPL5; RPS27; RPS7; RPS27A; RPL31; CXCR4; RPL32; RPL15; RPL14; RPL29; RPL24; RPL35A; RPL9; RPL34; RPS3A; RPL37; RPS23; RPS14; RPL10A; RPS12; RPL10; RPS20; RPL7; RPL30; PABPC1; RPS6; RPL7A; RPLP2; RPL27A; RPS13; RPS25; RPS24; NELL2; RPL41; RPL6; UBC; RPL21; RPS29; RPS27L; RPL4; RPLP1; RPS17; RPS15A; RPL13; RPL26; RPL23A; RPL23; RPL19; RPL27; RPL38; RPS21; RPL36; RPS28; RPL18A; UBA52; RPS16; RPS19; RPL18; RPL13A; RPS11; RPS5
R-HSA-8868773	rRNA processing in the nucleus and cytosol	4.30	0.00e+00	0.00e+00	61/160	RPL22; RPL11; RPS8; RPL5; RPS27; RPS7; RPS27A; RPL31; RPL32; RPL15; RPL14; RPL29; RPL24; RPL35A; RPL9; RPL34; RPS3A; RPL37; RPS23; RPS14; RPL10A; RPS12; RPL10; RPS20; RPL7; RPL30; RPS6; RPL7A; RPLP2; RPL27A; RPS13; RPS25; DDX21; RPS24; RPL41; RPL6; RPL21; RPS29; RPS27L; RPL4; RPLP1; RPS17; RPS15A; RPL13; RPL26; RPL23A; RPL23; RPL19; RPL27; RPL38; RPS21; RPL36; RPS28; RPL18A; UBA52; RPS16; RPS19; RPL18; RPL13A; RPS11; RPS5
R-HSA-500792	GPCR ligand binding	4.23	8.52e-06	1.80e-04	12/32	UTS2; CD55; CXCR4; CXCR6; PTGER4; F2R; ANXA1; LPAR6; GPR183; GPR68; CCL5; CCR7
R-HSA-72312	rRNA processing	4.15	0.00e+00	0.00e+00	61/166	RPL22; RPL11; RPS8; RPL5; RPS27; RPS7; RPS27A; RPL31; RPL32; RPL15; RPL14; RPL29; RPL24; RPL35A; RPL9; RPL34; RPS3A; RPL37; RPS23; RPS14; RPL10A; RPS12; RPL10; RPS20; RPL7; RPL30; RPS6; RPL7A; RPLP2; RPL27A; RPS13; RPS25; DDX21; RPS24; RPL41; RPL6; RPL21; RPS29; RPS27L; RPL4; RPLP1; RPS17; RPS15A; RPL13; RPL26; RPL23A; RPL23; RPL19; RPL27; RPL38; RPS21; RPL36; RPS28; RPL18A; UBA52; RPS16; RPS19; RPL18; RPL13A; RPS11; RPS5
R-HSA-202733	Cell surface interactions at the vascular wall	4.03	1.28e-06	3.17e-05	15/42	CD58; CD2; CD84; FCER1G; SELL; GYPC; ITGA4; CD74; FYN; CD99; DOK2; CD44; JAML; ITGB1; PECAM1
R-HSA-202433	Generation of second messenger molecules	3.92	5.23e-04	9.25e-03	8/23	FYB; HLA-DRA; HLA-DRB5; HLA-DRB1; HLA-DQA1; HLA-DQB1; HLA-DPA1; HLA-DPB1
R-HSA-422475	Axon guidance	3.72	0.00e+00	0.00e+00	84/255	RPL22; RPL11; RPS8; RPL5; RHOC; RPS27; PTPRC; RPS7; SPTBN1; RPS27A; RPL31; CXCR4; ARPC2; RPL32; RPL15; RPL14; RPL29; RPL24; RPL35A; RPL9; RPL34; RPS3A; RPL37; ITGA1; RPS23; RPS14; RPL10A; HSP90AB1; FYN; RPS12; SH3KBP1; RPL10; DOK2; FGFR1; RPS20; RPL7; RPL30; PABPC1; RPS6; TLN1; RPL7A; RPLP2; RPL27A; RPS13; CFL1; RPS25; ARHGEF12; ITGB1; RPS24; ABLIM1; NELL2; TUBA1B; RPL41; MYL6; RPL6; UBC; RPL21; RPS29; RPS27L; RPL4; RPLP1; RPS17; RPS15A; RPL13; RPL26; RPL23A; RPL23; RPL19; RPL27; RPL38; PRNP; RPS21; RPL36; RPS28; RPL18A; UBA52; RPS16; RPS19; ARHGAP35; RPL18; RPL13A; RPS11; RPS5; MAPK1
R-HSA-71291	Metabolism of amino acids and derivatives	3.45	0.00e+00	0.00e+00	62/203	RPL22; RPL11; RPS8; RPL5; RPS27; RPS7; RPS27A; RPL31; RPL32; RPL15; RPL14; RPL29; RPL24; RPL35A; RPL9; RPL34; RPS3A; RPL37; SERINC5; RPS23; RPS14; RPL10A; RPS12; RPL10; RPS20; RPL7; RPL30; RPS6; RPL7A; RPLP2; RPL27A; RPS13; RPS25; RPS24; RPL41; RPL6; RPL21; RPS29; RPS27L; RPL4; RPLP1; RPS17; RPS15A; RPL13; RPL26; RPL23A; RPL23; RPL19; RPL27; RPL38; RPS21; OAZ1; RPL36; RPS28; RPL18A; UBA52; RPS16; RPS19; RPL18; RPL13A; RPS11; RPS5
R-HSA-72766	Translation	3.20	0.00e+00	0.00e+00	73/257	RPL22; RPL11; RPS8; RPL5; RPS27; RPS7; RPS27A; RPL31; EEF1B2; RPL32; RPL15; RPL14; RPL29; RPL24; RPL35A; RPL9; RPL34; RPS3A; RPL37; RPS23; RPS14; RPL10A; MRPL14; EEF1A1; RPS12; EIF2S3; RPL10; RPS20; RPL7; RPL30; PABPC1; EIF3E; EIF3H; RPS6; RPL7A; RPLP2; CARS; RPL27A; RPS13; RPS25; RPS24; RPL41; RPL6; RPL21; RPS29; SRP14; RPS27L; RPL4; RPLP1; RPS17; RPS15A; RPL13; RPL26; RPL23A; RPL23; RPL19; RPL27; MRPL10; RPL38; SEC11C; RPS21; EEF2; RPL36; RPS28; RPL18A; UBA52; RPS16; RPS19; RPL18; RPL13A; RPS11; RPS5; EIF3L
R-HSA-1500931	Cell-Cell communication	3.17	1.35e-03	2.21e-02	9/32	SPTBN1; FYB; FYN; SKAP2; FLNA; ITGB1; ACTN1; IQGAP1; ACTN4
R-HSA-1474244	Extracellular matrix organization	3.03	6.22e-04	1.06e-02	11/41	ITGA4; ITGA1; CAST; CTSD; CD44; ITGB1; ADAM8; ACTN1; ICAM2; PECAM1; CAPN12
R-HSA-1266738	Developmental Biology	2.88	0.00e+00	0.00e+00	91/356	RPL22; RPL11; RPS8; JUN; RPL5; RHOC; RPS27; PTPRC; RPS7; SPTBN1; RPS27A; RPL31; CXCR4; ARPC2; RPL32; RPL15; RPL14; RPL29; FOXP1; RPL24; RPL35A; RBPJ; RPL9; H2AFZ; RPL34; RPS3A; RPL37; ITGA1; RPS23; RPS14; RPL10A; HSP90AB1; FYN; RPS12; PERP; SH3KBP1; RPL10; DOK2; FGFR1; CEBPD; RPS20; RPL7; RPL30; PABPC1; RPS6; TLN1; RPL7A; RPLP2; RPL27A; RPS13; CFL1; RPS25; ARHGEF12; ITGB1; RPS24; ABLIM1; NELL2; TUBA1B; RPL41; MYL6; RPL6; UBC; RPL21; RPS29; RPS27L; RPL4; RPLP1; RPS17; RPS15A; RPL13; RPL26; RPL23A; RPL23; RPL19; RPL27; RPL38; H3F3B; PRNP; RPS21; RPL36; RPS28; RPL18A; UBA52; RPS16; RPS19; ARHGAP35; RPL18; RPL13A; RPS11; RPS5; MAPK1
R-HSA-5663205	Infectious disease	2.81	0.00e+00	0.00e+00	74/297	RPL22; RPL11; RPS8; RPL5; RPS27; RPS7; EIF2AK2; RPS27A; RPL31; CXCR4; RPL32; RPL15; RPL14; RPL29; RPL24; RPL35A; RPL9; ANTXR2; RPL34; RPS3A; RPL37; RPS23; RPS14; NPM1; RPL10A; HSP90AB1; FYN; RPS12; SLC25A6; SH3KBP1; SLC25A5; RPL10; RPS20; RPL7; RPL30; RPS6; RPL7A; RPLP2; RPL27A; RPS13; RPS25; RPS24; RPL41; RPL6; UBC; RPL21; RPS29; B2M; RPS27L; RPL4; RPLP1; RPS17; RPS15A; RPL13; RPL26; RPL23A; RPL23; RPL19; RPL27; RPL38; RPS21; EEF2; RPL36; RPS28; AP1M1; RPL18A; UBA52; RPS16; RPS19; RPL18; RPL13A; RPS11; RPS5; APOBEC3G
R-HSA-2132295	MHC class II antigen presentation	2.69	2.81e-04	5.07e-03	15/63	CD74; HLA-DRA; HLA-DRB5; HLA-DRB1; HLA-DQA1; HLA-DQB1; HLA-DMB; HLA-DPA1; HLA-DPB1; CTSD; CTSC; LAG3; TUBA1B; CTSA; AP1M1
R-HSA-418594	G alpha (i) signalling events	2.53	5.72e-04	9.92e-03	15/67	DHRS3; RGS1; CXCR4; CXCR6; CAMK4; GPSM3; ANXA1; RGS10; GPR183; CCL5; CCL4; CCL4L2; CCR7; MAPK1
R-HSA-76005	Response to elevated platelet cytosolic Ca2+	2.51	2.16e-03	3.40e-02	12/54	PLEK; ANXA5; FLNA; TLN1; CFL1; CTSW; SRGN; CD63; ACTN1; PRKCB; PECAM1; ACTN4
R-HSA-372790	Signaling by GPCR	2.44	7.69e-06	1.67e-04	27/125	UTS2; DHRS3; RHOC; RGS1; CD55; CXCR4; CXCR6; PTGER4; F2R; CAMK4; REEP5; GPSM3; ANXA1; PDE3B; ARHGEF12; RGS10; DGKA; LPAR6; GPR183; GPR68; PRKCB; CCL5; CCL4; CCL4L2; CCR7; MAPK1
R-HSA-388396	GPCR downstream signalling	2.38	1.72e-05	3.55e-04	26/123	UTS2; DHRS3; RHOC; RGS1; CXCR4; CXCR6; PTGER4; F2R; CAMK4; REEP5; GPSM3; ANXA1; PDE3B; ARHGEF12; RGS10; DGKA; LPAR6; GPR183; GPR68; PRKCB; CCL5; CCL4; CCL4L2; CCR7; MAPK1
R-HSA-109582	Hemostasis	2.17	1.61e-06	3.87e-05	39/203	RAP1A; CD58; CD2; CD84; FCER1G; SELL; ATP2B4; PLEK; GYPC; ITGA4; ANXA5; ITGA1; F2R; CD74; FYN; CD99; FLNA; DOK2; TLN1; PDE3B; CD44; CFL1; CTSW; JAML; GATA3; ITGB1; SRGN; KIF21A; TUBA1B; CD63; DGKA; ACTN1; ANXA2; PRKCB; C1QBP; PECAM1; H3F3B; ACTN4; MAPK1

Factor 2 : 136 significant Reactome pathways

GeneSet	description	enrichRatio	pValue	FDR	GeneRatio	geneSymbols
R-HSA-156902	Peptide chain elongation	9.57	0.00e+00	0.00e+00	61/84	RPL11; RPS8; RPL5; RPS27; RPS7; RPS27A; RPL31; RPL32; RPL15; RPL14; RPL29; RPL24; RPL22L1; RPL35A; RPL9; RPL34; RPS3A; RPL37; RPS23; RPS14; RPS18; RPS10; EEF1A1; RPS12; RPS4X; RPL39; RPL10; RPS20; RPL7; RPL30; RPL12; RPL7A; RPLP2; RPL27A; RPS13; RPS3; RPS25; RPL21; RPS29; RPLP1; RPS15A; RPL13; RPL26; RPL23A; RPL23; RPL19; RPL27; RPL38; RPS15; EEF2; RPL36; RPS28; UBA52; RPS16; RPS19; RPL18; RPL13A; RPS11; RPL28; RPS5; RPL3
R-HSA-192823	Viral mRNA Translation	9.26	0.00e+00	0.00e+00	59/84	RPL11; RPS8; RPL5; RPS27; RPS7; RPS27A; RPL31; RPL32; RPL15; RPL14; RPL29; RPL24; RPL22L1; RPL35A; RPL9; RPL34; RPS3A; RPL37; RPS23; RPS14; RPS18; RPS10; RPS12; RPS4X; RPL39; RPL10; RPS20; RPL7; RPL30; RPL12; RPL7A; RPLP2; RPL27A; RPS13; RPS3; RPS25; RPL21; RPS29; RPLP1; RPS15A; RPL13; RPL26; RPL23A; RPL23; RPL19; RPL27; RPL38; RPS15; RPL36; RPS28; UBA52; RPS16; RPS19; RPL18; RPL13A; RPS11; RPL28; RPS5; RPL3
R-HSA-156842	Eukaryotic Translation Elongation	9.24	0.00e+00	0.00e+00	61/87	RPL11; RPS8; RPL5; RPS27; RPS7; RPS27A; RPL31; RPL32; RPL15; RPL14; RPL29; RPL24; RPL22L1; RPL35A; RPL9; RPL34; RPS3A; RPL37; RPS23; RPS14; RPS18; RPS10; EEF1A1; RPS12; RPS4X; RPL39; RPL10; RPS20; RPL7; RPL30; RPL12; RPL7A; RPLP2; RPL27A; RPS13; RPS3; RPS25; RPL21; RPS29; RPLP1; RPS15A; RPL13; RPL26; RPL23A; RPL23; RPL19; RPL27; RPL38; RPS15; EEF2; RPL36; RPS28; UBA52; RPS16; RPS19; RPL18; RPL13A; RPS11; RPL28; RPS5; RPL3
R-HSA-5334118	DNA methylation	9.23	1.32e-06	2.94e-05	7/10	HIST2H2AC; H3F3A; H2AFZ; HIST1H4C; H2AFV; H3F3B; DNMT1
R-HSA-2408557	Selenocysteine synthesis	9.15	0.00e+00	0.00e+00	59/85	RPL11; RPS8; RPL5; RPS27; RPS7; RPS27A; RPL31; RPL32; RPL15; RPL14; RPL29; RPL24; RPL22L1; RPL35A; RPL9; RPL34; RPS3A; RPL37; RPS23; RPS14; RPS18; RPS10; RPS12; RPS4X; RPL39; RPL10; RPS20; RPL7; RPL30; RPL12; RPL7A; RPLP2; RPL27A; RPS13; RPS3; RPS25; RPL21; RPS29; RPLP1; RPS15A; RPL13; RPL26; RPL23A; RPL23; RPL19; RPL27; RPL38; RPS15; RPL36; RPS28; UBA52; RPS16; RPS19; RPL18; RPL13A; RPS11; RPL28; RPS5; RPL3
R-HSA-2299718	Condensation of Prophase Chromosomes	9.13	4.01e-08	9.65e-07	9/13	HIST2H2AC; H3F3A; SMC4; H2AFZ; HIST1H4C; H2AFV; SMC2; SET; H3F3B
R-HSA-72764	Eukaryotic Translation Termination	8.94	0.00e+00	0.00e+00	59/87	RPL11; RPS8; RPL5; RPS27; RPS7; RPS27A; RPL31; RPL32; RPL15; RPL14; RPL29; RPL24; RPL22L1; RPL35A; RPL9; RPL34; RPS3A; RPL37; RPS23; RPS14; RPS18; RPS10; RPS12; RPS4X; RPL39; RPL10; RPS20; RPL7; RPL30; RPL12; RPL7A; RPLP2; RPL27A; RPS13; RPS3; RPS25; RPL21; RPS29; RPLP1; RPS15A; RPL13; RPL26; RPL23A; RPL23; RPL19; RPL27; RPL38; RPS15; RPL36; RPS28; UBA52; RPS16; RPS19; RPL18; RPL13A; RPS11; RPL28; RPS5; RPL3
R-HSA-975956	Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)	8.84	0.00e+00	0.00e+00	59/88	RPL11; RPS8; RPL5; RPS27; RPS7; RPS27A; RPL31; RPL32; RPL15; RPL14; RPL29; RPL24; RPL22L1; RPL35A; RPL9; RPL34; RPS3A; RPL37; RPS23; RPS14; RPS18; RPS10; RPS12; RPS4X; RPL39; RPL10; RPS20; RPL7; RPL30; RPL12; RPL7A; RPLP2; RPL27A; RPS13; RPS3; RPS25; RPL21; RPS29; RPLP1; RPS15A; RPL13; RPL26; RPL23A; RPL23; RPL19; RPL27; RPL38; RPS15; RPL36; RPS28; UBA52; RPS16; RPS19; RPL18; RPL13A; RPS11; RPL28; RPS5; RPL3
R-HSA-72689	Formation of a pool of free 40S subunits	8.46	0.00e+00	0.00e+00	61/95	RPL11; RPS8; RPL5; RPS27; RPS7; RPS27A; RPL31; RPL32; RPL15; RPL14; RPL29; RPL24; RPL22L1; RPL35A; RPL9; RPL34; RPS3A; RPL37; RPS23; RPS14; RPS18; RPS10; RPS12; EIF1AX; RPS4X; RPL39; RPL10; RPS20; RPL7; RPL30; EIF3E; RPL12; RPL7A; RPLP2; RPL27A; RPS13; RPS3; RPS25; RPL21; RPS29; RPLP1; RPS15A; RPL13; RPL26; RPL23A; RPL23; RPL19; RPL27; RPL38; RPS15; RPL36; RPS28; UBA52; RPS16; RPS19; RPL18; RPL13A; RPS11; RPL28; RPS5; RPL3
R-HSA-69190	DNA strand elongation	7.91	2.93e-05	5.00e-04	6/10	MCM3; RPA3; POLD2; RFC2; MCM7; PCNA
R-HSA-140342	Apoptosis induced DNA fragmentation	7.91	2.93e-05	5.00e-04	6/10	HMGB2; HIST1H1C; HIST1H1E; HIST1H1D; HIST1H1B; HMGB1
R-HSA-211227	Activation of DNA fragmentation factor	7.91	2.93e-05	5.00e-04	6/10	HMGB2; HIST1H1C; HIST1H1E; HIST1H1D; HIST1H1B; HMGB1
R-HSA-2408522	Selenoamino acid metabolism	7.86	0.00e+00	0.00e+00	59/99	RPL11; RPS8; RPL5; RPS27; RPS7; RPS27A; RPL31; RPL32; RPL15; RPL14; RPL29; RPL24; RPL22L1; RPL35A; RPL9; RPL34; RPS3A; RPL37; RPS23; RPS14; RPS18; RPS10; RPS12; RPS4X; RPL39; RPL10; RPS20; RPL7; RPL30; RPL12; RPL7A; RPLP2; RPL27A; RPS13; RPS3; RPS25; RPL21; RPS29; RPLP1; RPS15A; RPL13; RPL26; RPL23A; RPL23; RPL19; RPL27; RPL38; RPS15; RPL36; RPS28; UBA52; RPS16; RPS19; RPL18; RPL13A; RPS11; RPL28; RPS5; RPL3
R-HSA-156827	L13a-mediated translational silencing of Ceruloplasmin expression	7.66	0.00e+00	0.00e+00	61/105	RPL11; RPS8; RPL5; RPS27; RPS7; RPS27A; RPL31; RPL32; RPL15; RPL14; RPL29; RPL24; RPL22L1; RPL35A; RPL9; RPL34; RPS3A; RPL37; RPS23; RPS14; RPS18; RPS10; RPS12; EIF1AX; RPS4X; RPL39; RPL10; RPS20; RPL7; RPL30; EIF3E; RPL12; RPL7A; RPLP2; RPL27A; RPS13; RPS3; RPS25; RPL21; RPS29; RPLP1; RPS15A; RPL13; RPL26; RPL23A; RPL23; RPL19; RPL27; RPL38; RPS15; RPL36; RPS28; UBA52; RPS16; RPS19; RPL18; RPL13A; RPS11; RPL28; RPS5; RPL3
R-HSA-927802	Nonsense-Mediated Decay (NMD)	7.66	0.00e+00	0.00e+00	61/105	RPL11; RPS8; RPL5; RPS27; RPS7; RPS27A; RPL31; RPL32; RPL15; RPL14; RPL29; RPL24; RPL22L1; RPL35A; RPL9; RPL34; RPS3A; RPL37; RPS23; RPS14; RPS18; RPS10; RPS12; RPS4X; RPL39; RPL10; RPS20; RPL7; RPL30; RPL12; RPL7A; RPLP2; RPL27A; RPS13; RPS3; RPS25; MAGOHB; RPL21; RPS29; RPLP1; RPS15A; RPL13; RPL26; RPL23A; RPL23; RPL19; RPL27; RPL38; EIF4A3; RPS15; RPL36; RPS28; UBA52; RPS16; RPS19; RPL18; RPL13A; RPS11; RPL28; RPS5; RPL3
R-HSA-975957	Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)	7.66	0.00e+00	0.00e+00	61/105	RPL11; RPS8; RPL5; RPS27; RPS7; RPS27A; RPL31; RPL32; RPL15; RPL14; RPL29; RPL24; RPL22L1; RPL35A; RPL9; RPL34; RPS3A; RPL37; RPS23; RPS14; RPS18; RPS10; RPS12; RPS4X; RPL39; RPL10; RPS20; RPL7; RPL30; RPL12; RPL7A; RPLP2; RPL27A; RPS13; RPS3; RPS25; MAGOHB; RPL21; RPS29; RPLP1; RPS15A; RPL13; RPL26; RPL23A; RPL23; RPL19; RPL27; RPL38; EIF4A3; RPS15; RPL36; RPS28; UBA52; RPS16; RPS19; RPL18; RPL13A; RPS11; RPL28; RPS5; RPL3
R-HSA-72706	GTP hydrolysis and joining of the 60S ribosomal subunit	7.59	0.00e+00	0.00e+00	61/106	RPL11; RPS8; RPL5; RPS27; RPS7; RPS27A; RPL31; RPL32; RPL15; RPL14; RPL29; RPL24; RPL22L1; RPL35A; RPL9; RPL34; RPS3A; RPL37; RPS23; RPS14; RPS18; RPS10; RPS12; EIF1AX; RPS4X; RPL39; RPL10; RPS20; RPL7; RPL30; EIF3E; RPL12; RPL7A; RPLP2; RPL27A; RPS13; RPS3; RPS25; RPL21; RPS29; RPLP1; RPS15A; RPL13; RPL26; RPL23A; RPL23; RPL19; RPL27; RPL38; RPS15; RPL36; RPS28; UBA52; RPS16; RPS19; RPL18; RPL13A; RPS11; RPL28; RPS5; RPL3
R-HSA-1799339	SRP-dependent cotranslational protein targeting to membrane	7.46	0.00e+00	0.00e+00	60/106	RPL11; RPS8; RPL5; RPS27; SRP9; RPS7; RPS27A; RPL31; RPL32; RPL15; RPL14; RPL29; RPL24; RPL22L1; RPL35A; RPL9; RPL34; RPS3A; RPL37; RPS23; RPS14; RPS18; RPS10; RPS12; RPS4X; RPL39; RPL10; RPS20; RPL7; RPL30; RPL12; RPL7A; RPLP2; RPL27A; RPS13; RPS3; RPS25; RPL21; RPS29; RPLP1; RPS15A; RPL13; RPL26; RPL23A; RPL23; RPL19; RPL27; RPL38; RPS15; RPL36; RPS28; UBA52; RPS16; RPS19; RPL18; RPL13A; RPS11; RPL28; RPS5; RPL3
R-HSA-3371511	HSF1 activation	7.19	6.03e-05	9.17e-04	6/11	HSP90AB1; EEF1A1; RPA3; PTGES3; HSP90AA1; YWHAE
R-HSA-73728	RNA Polymerase I Promoter Opening	7.19	6.03e-05	9.17e-04	6/11	HIST2H2AC; H3F3A; H2AFZ; HIST1H4C; H2AFV; H3F3B
R-HSA-72613	Eukaryotic Translation Initiation	7.18	0.00e+00	0.00e+00	61/112	RPL11; RPS8; RPL5; RPS27; RPS7; RPS27A; RPL31; RPL32; RPL15; RPL14; RPL29; RPL24; RPL22L1; RPL35A; RPL9; RPL34; RPS3A; RPL37; RPS23; RPS14; RPS18; RPS10; RPS12; EIF1AX; RPS4X; RPL39; RPL10; RPS20; RPL7; RPL30; EIF3E; RPL12; RPL7A; RPLP2; RPL27A; RPS13; RPS3; RPS25; RPL21; RPS29; RPLP1; RPS15A; RPL13; RPL26; RPL23A; RPL23; RPL19; RPL27; RPL38; RPS15; RPL36; RPS28; UBA52; RPS16; RPS19; RPL18; RPL13A; RPS11; RPL28; RPS5; RPL3
R-HSA-72737	Cap-dependent Translation Initiation	7.18	0.00e+00	0.00e+00	61/112	RPL11; RPS8; RPL5; RPS27; RPS7; RPS27A; RPL31; RPL32; RPL15; RPL14; RPL29; RPL24; RPL22L1; RPL35A; RPL9; RPL34; RPS3A; RPL37; RPS23; RPS14; RPS18; RPS10; RPS12; EIF1AX; RPS4X; RPL39; RPL10; RPS20; RPL7; RPL30; EIF3E; RPL12; RPL7A; RPLP2; RPL27A; RPS13; RPS3; RPS25; RPL21; RPS29; RPLP1; RPS15A; RPL13; RPL26; RPL23A; RPL23; RPL19; RPL27; RPL38; RPS15; RPL36; RPS28; UBA52; RPS16; RPS19; RPL18; RPL13A; RPS11; RPL28; RPS5; RPL3
R-HSA-72695	Formation of the ternary complex, and subsequently, the 43S complex	6.87	2.22e-16	6.64e-15	25/48	RPS8; RPS27; RPS7; RPS27A; RPS3A; RPS23; RPS14; RPS18; RPS10; RPS12; EIF1AX; RPS4X; RPS20; EIF3E; RPS13; RPS3; RPS25; RPS29; RPS15A; RPS15; RPS28; RPS16; RPS19; RPS11; RPS5
R-HSA-168273	Influenza Viral RNA Transcription and Replication	6.76	0.00e+00	0.00e+00	61/119	RPL11; RPS8; RPL5; RPS27; RPS7; RPS27A; RPL31; RPL32; RPL15; RPL14; RPL29; RPL24; RPL22L1; RPL35A; RPL9; RPL34; RPS3A; RPL37; RPS23; RPS14; RPS18; RPS10; RPS12; RPS4X; RPL39; RPL10; RPS20; RPL7; RPL30; RPL12; RPL7A; RPLP2; POLR2L; RPL27A; RPS13; RPS3; RPS25; RPL21; RPS29; HSP90AA1; RPLP1; RPS15A; RPL13; RPL26; RPL23A; RPL23; RPL19; RPL27; RPL38; RPS15; RPL36; RPS28; UBA52; RPS16; RPS19; RPL18; RPL13A; RPS11; RPL28; RPS5; RPL3
R-HSA-5626467	RHO GTPases activate IQGAPs	6.59	7.47e-06	1.54e-04	8/16	CALM2; ACTB; TUBB4B; TUBA1B; TUBA1C; CALM1; ACTG1; CALM3
R-HSA-8876725	Protein methylation	6.59	1.13e-04	1.58e-03	6/12	CALM2; EEF1A1; HSPA8; CALM1; EEF2; CALM3
R-HSA-427359	SIRT1 negatively regulates rRNA expression	6.59	1.13e-04	1.58e-03	6/12	HIST2H2AC; H3F3A; H2AFZ; HIST1H4C; H2AFV; H3F3B
R-HSA-5625886	Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3	6.59	1.13e-04	1.58e-03	6/12	HIST2H2AC; H3F3A; H2AFZ; HIST1H4C; H2AFV; H3F3B
R-HSA-168255	Influenza Life Cycle	6.49	0.00e+00	0.00e+00	63/128	RPL11; RPS8; RPL5; RPS27; RPS7; RPS27A; RPL31; RPL32; RPL15; RPL14; RPL29; RPL24; RPL22L1; RPL35A; RPL9; RPL34; RPS3A; RPL37; RPS23; RPS14; RPS18; RPS10; RPS12; RPS4X; RPL39; RPL10; RPS20; RPL7; RPL30; RPL12; RPL7A; RPLP2; POLR2L; RPL27A; RPS13; RPS3; RPS25; RAN; RPL21; RPS29; HSP90AA1; RPLP1; RPS15A; RPL13; RPL26; RPL23A; RPL23; RPL19; RPL27; RPL38; RPS15; RPL36; RPS28; CALR; UBA52; RPS16; RPS19; RPL18; RPL13A; RPS11; RPL28; RPS5; RPL3
R-HSA-168254	Influenza Infection	6.16	0.00e+00	0.00e+00	64/137	RPL11; RPS8; RPL5; RPS27; RPS7; RPS27A; RPL31; RPL32; RPL15; RPL14; RPL29; RPL24; RPL22L1; RPL35A; RPL9; RPL34; RPS3A; RPL37; RPS23; RPS14; RPS18; RPS10; RPS12; RPS4X; RPL39; RPL10; RPS20; RPL7; RPL30; RPL12; RPL7A; RPLP2; POLR2L; RPL27A; RPS13; RPS3; RPS25; RAN; RPL21; RPS29; HSP90AA1; RPLP1; RPS15A; RPL13; RPL26; RPL23A; RPL23; RPL19; RPL27; KPNA2; RPL38; RPS15; RPL36; RPS28; CALR; UBA52; RPS16; RPS19; RPL18; RPL13A; RPS11; RPL28; RPS5; RPL3
R-HSA-72649	Translation initiation complex formation	5.99	1.38e-14	3.85e-13	25/55	RPS8; RPS27; RPS7; RPS27A; RPS3A; RPS23; RPS14; RPS18; RPS10; RPS12; EIF1AX; RPS4X; RPS20; EIF3E; RPS13; RPS3; RPS25; RPS29; RPS15A; RPS15; RPS28; RPS16; RPS19; RPS11; RPS5
R-HSA-72702	Ribosomal scanning and start codon recognition	5.99	1.38e-14	3.85e-13	25/55	RPS8; RPS27; RPS7; RPS27A; RPS3A; RPS23; RPS14; RPS18; RPS10; RPS12; EIF1AX; RPS4X; RPS20; EIF3E; RPS13; RPS3; RPS25; RPS29; RPS15A; RPS15; RPS28; RPS16; RPS19; RPS11; RPS5
R-HSA-212300	PRC2 methylates histones and DNA	5.93	5.84e-06	1.27e-04	9/20	HIST2H2AC; H3F3A; H2AFZ; HIST1H4C; H2AFV; EZH2; PHF19; H3F3B; DNMT1
R-HSA-9010553	Regulation of expression of SLITs and ROBOs	5.92	0.00e+00	0.00e+00	66/147	RPL11; RPS8; RPL5; RPS27; RPS7; RPS27A; RPL31; RPL32; RPL15; RPL14; RPL29; RPL24; RPL22L1; RPL35A; RPL9; RPL34; RPS3A; RPL37; RPS23; RPS14; RPS18; RPS10; RPS12; RPS4X; RPL39; RPL10; RPS20; RPL7; RPL30; RPL12; RPL7A; RPLP2; RPL27A; RPS13; PSMC3; RPS3; RPS25; MAGOHB; RPL21; PSME2; RPS29; RPLP1; TCEB2; RPS15A; RPL13; RPL26; RPL23A; PSMB3; RPL23; RPL19; RPL27; RPL38; EIF4A3; PSMA7; RPS15; RPL36; RPS28; UBA52; RPS16; RPS19; RPL18; RPL13A; RPS11; RPL28; RPS5; RPL3
R-HSA-72662	Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S	5.89	2.33e-14	6.32e-13	25/56	RPS8; RPS27; RPS7; RPS27A; RPS3A; RPS23; RPS14; RPS18; RPS10; RPS12; EIF1AX; RPS4X; RPS20; EIF3E; RPS13; RPS3; RPS25; RPS29; RPS15A; RPS15; RPS28; RPS16; RPS19; RPS11; RPS5
R-HSA-912446	Meiotic recombination	5.86	2.22e-05	4.28e-04	8/18	HIST2H2AC; H3F3A; H2AFZ; HIST1H4C; RPA3; H2AFV; CDK4; H3F3B
R-HSA-157858	Gap junction trafficking and regulation	5.49	1.23e-03	1.23e-02	5/12	ACTB; TUBB4B; TUBA1B; TUBA1C; ACTG1
R-HSA-190828	Gap junction trafficking	5.49	1.23e-03	1.23e-02	5/12	ACTB; TUBB4B; TUBA1B; TUBA1C; ACTG1
R-HSA-2559584	Formation of Senescence-Associated Heterochromatin Foci (SAHF)	5.49	1.23e-03	1.23e-02	5/12	LMNB1; HIST1H1C; HIST1H1E; HIST1H1D; HIST1H1B
R-HSA-3928662	EPHB-mediated forward signaling	5.43	1.34e-04	1.79e-03	7/17	ARPC5; ACTR3; ARPC2; ACTB; ARPC1B; CFL1; ACTG1
R-HSA-499943	Interconversion of nucleotide di- and triphosphates	5.43	1.34e-04	1.79e-03	7/17	DTYMK; TXN; RRM1; DUT; DCTPP1; NME1; TYMS
R-HSA-376176	Signaling by ROBO receptors	5.37	0.00e+00	0.00e+00	68/167	RPL11; RPS8; RPL5; RPS27; RPS7; RPS27A; RPL31; RPL32; RPL15; RPL14; RPL29; RPL24; RPL22L1; RPL35A; RPL9; RPL34; RPS3A; RPL37; RPS23; RPS14; RPS18; RPS10; RPS12; RPS4X; RPL39; RPL10; RPS20; RPL7; RPL30; RPL12; RPL7A; RPLP2; RPL27A; RPS13; PSMC3; RPS3; RPS25; MAGOHB; RPL21; PSME2; RPS29; EVL; RPLP1; TCEB2; RPS15A; RPL13; PFN1; RPL26; RPL23A; PSMB3; RPL23; RPL19; RPL27; RPL38; EIF4A3; PSMA7; RPS15; RPL36; RPS28; UBA52; RPS16; RPS19; RPL18; RPL13A; RPS11; RPL28; RPS5; RPL3
R-HSA-6791226	Major pathway of rRNA processing in the nucleolus and cytosol	5.33	0.00e+00	0.00e+00	61/151	RPL11; EBNA1BP2; RPS8; RPL5; RPS27; RPS7; RPS27A; RPL31; NCL; RPL32; RPL15; RPL14; RPL29; RPL24; RPL22L1; RPL35A; RPL9; RPL34; RPS3A; RPL37; RPS23; RPS14; RPS18; RPS10; RPS12; RPS4X; RPL39; RPL10; RPS20; RPL7; RPL30; RPL12; RPL7A; RPLP2; RPL27A; RPS13; RPS3; RPS25; RPL21; RPS29; RPLP1; RPS15A; RPL13; RPL26; RPL23A; RPL23; RPL19; RPL27; RPL38; RPS15; RPL36; RPS28; UBA52; RPS16; RPS19; RPL18; RPL13A; RPS11; RPL28; RPS5; RPL3
R-HSA-171306	Packaging Of Telomere Ends	5.27	4.72e-03	3.27e-02	4/10	HIST2H2AC; H2AFZ; HIST1H4C; H2AFV
R-HSA-174417	Telomere C-strand (Lagging Strand) Synthesis	5.27	4.72e-03	3.27e-02	4/10	RPA3; POLD2; RFC2; PCNA
R-HSA-5358508	Mismatch Repair	5.27	4.72e-03	3.27e-02	4/10	MSH6; RPA3; POLD2; PCNA
R-HSA-8868773	rRNA processing in the nucleus and cytosol	5.11	0.00e+00	0.00e+00	62/160	RPL11; EBNA1BP2; RPS8; RPL5; RPS27; RPS7; RPS27A; RPL31; NCL; RPL32; RPL15; RPL14; RPL29; RPL24; RPL22L1; RPL35A; RPL9; RPL34; RPS3A; RPL37; RPS23; RPS14; NHP2; RPS18; RPS10; RPS12; RPS4X; RPL39; RPL10; RPS20; RPL7; RPL30; RPL12; RPL7A; RPLP2; RPL27A; RPS13; RPS3; RPS25; RPL21; RPS29; RPLP1; RPS15A; RPL13; RPL26; RPL23A; RPL23; RPL19; RPL27; RPL38; RPS15; RPL36; RPS28; UBA52; RPS16; RPS19; RPL18; RPL13A; RPS11; RPL28; RPS5; RPL3
R-HSA-983189	Kinesins	5.07	1.88e-03	1.70e-02	5/13	TUBB4B; KIF20B; TUBA1B; TUBA1C; KIF22
R-HSA-110312	Translesion synthesis by REV1	5.07	1.88e-03	1.70e-02	5/13	RPS27A; RPA3; RFC2; PCNA; UBA52
R-HSA-5656121	Translesion synthesis by POLI	5.07	1.88e-03	1.70e-02	5/13	RPS27A; RPA3; RFC2; PCNA; UBA52
R-HSA-157579	Telomere Maintenance	4.94	3.46e-05	5.77e-04	9/24	HIST2H2AC; H2AFZ; NHP2; HIST1H4C; RPA3; POLD2; H2AFV; RFC2; PCNA
R-HSA-5696397	Gap-filling DNA repair synthesis and ligation in GG-NER	4.94	7.54e-04	8.60e-03	6/16	RPS27A; RPA3; POLD2; RFC2; PCNA; UBA52
R-HSA-72312	rRNA processing	4.92	0.00e+00	0.00e+00	62/166	RPL11; EBNA1BP2; RPS8; RPL5; RPS27; RPS7; RPS27A; RPL31; NCL; RPL32; RPL15; RPL14; RPL29; RPL24; RPL22L1; RPL35A; RPL9; RPL34; RPS3A; RPL37; RPS23; RPS14; NHP2; RPS18; RPS10; RPS12; RPS4X; RPL39; RPL10; RPS20; RPL7; RPL30; RPL12; RPL7A; RPLP2; RPL27A; RPS13; RPS3; RPS25; RPL21; RPS29; RPLP1; RPS15A; RPL13; RPL26; RPL23A; RPL23; RPL19; RPL27; RPL38; RPS15; RPL36; RPS28; UBA52; RPS16; RPS19; RPL18; RPL13A; RPS11; RPL28; RPS5; RPL3
R-HSA-5651801	PCNA-Dependent Long Patch Base Excision Repair	4.79	6.98e-03	4.41e-02	4/11	RPA3; POLD2; RFC2; PCNA
R-HSA-3371568	Attenuation phase	4.79	6.98e-03	4.41e-02	4/11	HSP90AB1; HSPA8; PTGES3; HSP90AA1
R-HSA-2995383	Initiation of Nuclear Envelope Reformation	4.79	6.98e-03	4.41e-02	4/11	LMNB1; BANF1; TMPO; VRK1
R-HSA-2995410	Nuclear Envelope Reassembly	4.79	6.98e-03	4.41e-02	4/11	LMNB1; BANF1; TMPO; VRK1
R-HSA-2025928	Calcineurin activates NFAT	4.79	6.98e-03	4.41e-02	4/11	CALM2; PPIA; CALM1; CALM3
R-HSA-5627123	RHO GTPases activate PAKs	4.71	2.74e-03	2.10e-02	5/14	CALM2; FLNA; MYL6; CALM1; CALM3
R-HSA-5655862	Translesion synthesis by POLK	4.71	2.74e-03	2.10e-02	5/14	RPS27A; RPA3; RFC2; PCNA; UBA52
R-HSA-180786	Extension of Telomeres	4.71	2.74e-03	2.10e-02	5/14	NHP2; RPA3; POLD2; RFC2; PCNA
R-HSA-5339562	Uptake and actions of bacterial toxins	4.65	1.09e-03	1.14e-02	6/17	CALM2; HSP90AB1; CALM1; HSP90AA1; EEF2; CALM3
R-HSA-5625740	RHO GTPases activate PKNs	4.55	2.94e-05	5.00e-04	10/29	HIST2H2AC; H3F3A; YWHAQ; H2AFZ; HIST1H4C; H2AFV; MYL6; YWHAE; H3F3B; YWHAH
R-HSA-445355	Smooth Muscle Contraction	4.39	1.54e-03	1.46e-02	6/18	CALM2; MYL6; CALM1; ANXA2; TPM4; CALM3
R-HSA-110314	Recognition of DNA damage by PCNA-containing replication complex	4.39	6.17e-04	7.13e-03	7/21	USP1; RPS27A; RPA3; POLD2; RFC2; PCNA; UBA52
R-HSA-110320	Translesion Synthesis by POLH	4.39	3.86e-03	2.81e-02	5/15	RPS27A; RPA3; RFC2; PCNA; UBA52
R-HSA-71291	Metabolism of amino acids and derivatives	4.29	0.00e+00	0.00e+00	66/203	RPL11; RPS8; RPL5; RPS27; RPS7; ODC1; RPS27A; RPL31; RPL32; RPL15; RPL14; RPL29; RPL24; RPL22L1; RPL35A; RPL9; RPL34; RPS3A; RPL37; RPS23; RPS14; RPS18; RPS10; RPS12; SMS; RPS4X; RPL39; RPL10; RPS20; RPL7; RPL30; RPL12; RPL7A; RPLP2; RPL27A; RPS13; PSMC3; RPS3; RPS25; RPL21; PSME2; RPS29; RPLP1; RPS15A; RPL13; RPL26; RPL23A; PSMB3; RPL23; RPL19; RPL27; RPL38; PSMA7; RPS15; OAZ1; RPL36; RPS28; UBA52; RPS16; RPS19; RPL18; RPL13A; RPS11; RPL28; RPS5; RPL3
R-HSA-1500620	Meiosis	4.27	2.32e-05	4.38e-04	11/34	HIST2H2AC; H3F3A; H2AFZ; LMNB1; HIST1H4C; RPA3; H2AFV; SMC1A; RAD21; CDK4; H3F3B
R-HSA-8950505	Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation	4.25	5.68e-05	8.96e-04	10/31	HNRNPDL; LMNB1; HNRNPA2B1; PPIA; CFL1; LCP1; PSME2; ANXA2; SNRPA1; MIF
R-HSA-422475	Axon guidance	4.24	0.00e+00	0.00e+00	82/255	RPL11; RPS8; RPL5; RPS27; ARPC5; RPS7; RPS27A; RPL31; ACTR3; ARPC2; RPL32; RPL15; RPL14; RPL29; RPL24; RPL22L1; RPL35A; RPL9; RPL34; RPS3A; RPL37; RPS23; RPS14; RPS18; RPS10; HSP90AB1; RPS12; ACTB; ARPC1B; RPS4X; RPL39; RPL10; RPS20; RPL7; RPL30; RPL12; RPL7A; TUBB4B; RPLP2; RPL27A; RPS13; PSMC3; CFL1; RPS3; RPS25; HSPA8; MAGOHB; TUBA1B; TUBA1C; MYL6; RPL21; PSME2; RPS29; EVL; HSP90AA1; RPLP1; TCEB2; RPS15A; RPL13; PFN1; RPL26; RPL23A; PSMB3; RPL23; RPL19; RPL27; RPL38; EIF4A3; ACTG1; PSMA7; RPS15; RPL36; RPS28; UBA52; RPS16; RPS19; RPL18; RPL13A; RPS11; RPL28; RPS5; RPL3
R-HSA-2559586	DNA Damage/Telomere Stress Induced Senescence	4.24	1.39e-04	1.80e-03	9/28	HIST2H2AC; H2AFZ; LMNB1; HIST1H1C; HIST1H4C; HIST1H1E; HIST1H1D; HIST1H1B; H2AFV
R-HSA-5250924	B-WICH complex positively regulates rRNA expression	4.24	1.39e-04	1.80e-03	9/28	HIST2H2AC; H3F3A; H2AFZ; DEK; HIST1H4C; ACTB; H2AFV; POLR2L; H3F3B
R-HSA-1221632	Meiotic synapsis	4.19	8.46e-04	9.29e-03	7/22	HIST2H2AC; H2AFZ; LMNB1; HIST1H4C; H2AFV; SMC1A; RAD21
R-HSA-5656169	Termination of translesion DNA synthesis	4.19	8.46e-04	9.29e-03	7/22	RPS27A; RPA3; POLD2; RFC2; KIAA0101; PCNA; UBA52
R-HSA-606279	Deposition of new CENPA-containing nucleosomes at the centromere	4.16	2.10e-03	1.81e-02	6/19	HIST2H2AC; H2AFZ; HIST1H4C; H2AFV; STRA13; CENPM
R-HSA-774815	Nucleosome assembly	4.16	2.10e-03	1.81e-02	6/19	HIST2H2AC; H2AFZ; HIST1H4C; H2AFV; STRA13; CENPM
R-HSA-6783310	Fanconi Anemia Pathway	4.12	5.27e-03	3.57e-02	5/16	USP1; RPS27A; RPA3; STRA13; UBA52
R-HSA-8982491	Glycogen metabolism	4.12	5.27e-03	3.57e-02	5/16	CALM2; RPS27A; CALM1; UBA52; CALM3
R-HSA-73886	Chromosome Maintenance	4.03	4.25e-05	6.95e-04	11/36	HIST2H2AC; H2AFZ; NHP2; HIST1H4C; RPA3; POLD2; H2AFV; RFC2; STRA13; PCNA; CENPM
R-HSA-1912408	Pre-NOTCH Transcription and Translation	4.01	1.14e-03	1.18e-02	7/23	HIST2H2AC; H3F3A; H2AFZ; HIST1H4C; H2AFV; TFDP1; H3F3B
R-HSA-427389	ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression	3.95	2.82e-03	2.12e-02	6/20	HIST2H2AC; H3F3A; H2AFZ; HIST1H4C; H2AFV; H3F3B
R-HSA-389958	Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding	3.95	2.82e-03	2.12e-02	6/20	CCT5; ACTB; TUBB4B; TUBA1B; TUBA1C; PFDN5
R-HSA-1474165	Reproduction	3.92	5.65e-05	8.96e-04	11/37	HIST2H2AC; H3F3A; H2AFZ; LMNB1; HIST1H4C; RPA3; H2AFV; SMC1A; RAD21; CDK4; H3F3B
R-HSA-163210	Formation of ATP by chemiosmotic coupling	3.88	7.01e-03	4.41e-02	5/17	ATP5G3; ATP5J2; ATP5G1; ATP5J; MT-ATP6
R-HSA-977225	Amyloid fiber formation	3.69	1.96e-03	1.71e-02	7/25	HIST2H2AC; H3F3A; RPS27A; H2AFZ; HIST1H4C; H3F3B; UBA52
R-HSA-9020591	Interleukin-12 signaling	3.66	2.31e-04	2.83e-03	10/36	HNRNPDL; LMNB1; HNRNPA2B1; PPIA; CFL1; LCP1; PSME2; ANXA2; SNRPA1; MIF
R-HSA-2559582	Senescence-Associated Secretory Phenotype (SASP)	3.63	1.24e-04	1.71e-03	11/40	HIST2H2AC; H3F3A; RPS27A; H2AFZ; HIST1H4C; H2AFV; CDK4; H3F3B; ANAPC11; UBE2C; UBA52
R-HSA-5663205	Infectious disease	3.55	0.00e+00	0.00e+00	80/297	RPL11; RPS8; RPL5; RPS27; RPS7; CALM2; RPS27A; RPL31; RPL32; RPL15; RPL14; RPL29; RPL24; RPL22L1; RPL35A; RPL9; RPL34; RPS3A; RPL37; RPS23; RPS14; RPS18; RPS10; HSP90AB1; RPS12; PPIA; RPS4X; SLC25A5; RPL39; RPL10; RPS20; RPL7; RPL30; RPL12; RPL7A; RPLP2; POLR2L; RPL27A; RPS13; PSMC3; SSRP1; BANF1; RPS3; RPS25; RAN; RPL21; SUPT16H; PSME2; RPS29; CALM1; HSP90AA1; RPLP1; TCEB2; RPS15A; RPL13; RPL26; RPL23A; PSMB3; RPL23; RPL19; RPL27; KPNA2; RPL38; PSMA7; RPS15; EEF2; RPL36; RPS28; CALR; UBA52; RPS16; RPS19; CALM3; RPL18; RPL13A; RPS11; RPL28; RPS5; RANBP1; RPL3
R-HSA-2559580	Oxidative Stress Induced Senescence	3.44	1.07e-04	1.57e-03	12/46	HIST2H2AC; H3F3A; RPS27A; H2AFZ; HIST1H4C; H2AFV; EZH2; TXN; CDK4; TFDP1; H3F3B; UBA52
R-HSA-3299685	Detoxification of Reactive Oxygen Species	3.44	6.04e-03	4.00e-02	6/23	PRDX1; ATOX1; CYCS; TXN; GSTP1; PRDX2
R-HSA-1266738	Developmental Biology	3.37	0.00e+00	0.00e+00	91/356	RPL11; RPS8; RPL5; HIST2H2AC; RPS27; ARPC5; H3F3A; RPS7; RPS27A; RPL31; ACTR3; ARPC2; RPL32; RPL15; RPL14; RPL29; RPL24; RPL22L1; RPL35A; RPL9; H2AFZ; RPL34; RPS3A; RPL37; RPS23; RPS14; HIST1H4C; RPS18; RPS10; HSP90AB1; RPS12; ACTB; H2AFV; ARPC1B; EZH2; RPS4X; RPL39; RPL10; RPS20; RPL7; RPL30; RPL12; RPL7A; TUBB4B; RPLP2; POLR2L; RPL27A; RPS13; PSMC3; CFL1; RPS3; RPS25; HSPA8; MAGOHB; TUBA1B; TUBA1C; MYL6; CDK4; RPL21; PSME2; RPS29; EVL; HSP90AA1; RPLP1; TCEB2; RPS15A; RPL13; PFN1; RPL26; RPL23A; PSMB3; RPL23; RPL19; RPL27; RPL38; H3F3B; EIF4A3; ACTG1; PSMA7; RPS15; RPL36; RPS28; UBA52; RPS16; RPS19; RPL18; RPL13A; RPS11; RPL28; RPS5; RPL3
R-HSA-72766	Translation	3.33	0.00e+00	0.00e+00	65/257	RPL11; RPS8; RPL5; RPS27; SRP9; RPS7; RPS27A; RPL31; RPL32; RPL15; RPL14; RPL29; RPL24; RPL22L1; RPL35A; RPL9; RPL34; RPS3A; RPL37; RPS23; RPS14; RPS18; RPS10; EEF1A1; RPS12; EIF1AX; RPS4X; RPL39; RPL10; RPS20; RPL7; RPL30; EIF3E; RPL12; RPL7A; RPLP2; RPL27A; RPS13; RPS3; RPS25; RPL21; RPS29; RPLP1; RPS15A; RPL13; RPL26; RPL23A; RPL23; RPL19; RPL27; RPL38; MRPL12; RPS15; EEF2; RPL36; RPS28; UBA52; RPS16; RPS19; RPL18; RPL13A; RPS11; RPL28; RPS5; RPL3
R-HSA-73777	RNA Polymerase I Chain Elongation	3.30	3.96e-03	2.84e-02	7/28	HIST2H2AC; H3F3A; H2AFZ; HIST1H4C; H2AFV; POLR2L; H3F3B
R-HSA-110313	Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template	3.30	3.96e-03	2.84e-02	7/28	RPS27A; RPA3; POLD2; RFC2; KIAA0101; PCNA; UBA52
R-HSA-8936459	RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function	3.30	7.56e-03	4.68e-02	6/24	HIST2H2AC; H3F3A; H2AFZ; HIST1H4C; H2AFV; H3F3B
R-HSA-195258	RHO GTPase Effectors	3.22	5.28e-10	1.37e-08	33/135	NUDC; HIST2H2AC; RPS27; ARPC5; CENPF; H3F3A; YWHAQ; CALM2; ACTR3; ARPC2; H2AFZ; MAD2L1; HIST1H4C; ACTB; H2AFV; ARPC1B; FLNA; TUBB4B; CFL1; TUBA1B; TUBA1C; MYL6; CALM1; EVL; YWHAE; PFN1; SKA2; H3F3B; ACTG1; NDC80; CALM3; YWHAH; CENPM
R-HSA-2029482	Regulation of actin dynamics for phagocytic cup formation	3.21	1.37e-03	1.33e-02	9/37	ARPC5; ACTR3; ARPC2; HSP90AB1; ACTB; ARPC1B; CFL1; HSP90AA1; ACTG1
R-HSA-1912422	Pre-NOTCH Expression and Processing	3.18	4.89e-03	3.36e-02	7/29	HIST2H2AC; H3F3A; H2AFZ; HIST1H4C; H2AFV; TFDP1; H3F3B
R-HSA-1445148	Translocation of SLC2A4 (GLUT4) to the plasma membrane	3.15	4.75e-04	5.57e-03	11/46	YWHAQ; CALM2; ACTB; TUBB4B; TUBA1B; TUBA1C; CALM1; YWHAE; ACTG1; CALM3; YWHAH
R-HSA-447115	Interleukin-12 family signaling	3.14	8.91e-04	9.53e-03	10/42	HNRNPDL; LMNB1; HNRNPA2B1; PPIA; CFL1; LCP1; PSME2; ANXA2; SNRPA1; MIF
R-HSA-73893	DNA Damage Bypass	3.01	3.83e-03	2.81e-02	8/35	USP1; RPS27A; RPA3; POLD2; RFC2; KIAA0101; PCNA; UBA52
R-HSA-75153	Apoptotic execution phase	2.98	7.22e-03	4.51e-02	7/31	HMGB2; LMNB1; HIST1H1C; HIST1H1E; HIST1H1D; HIST1H1B; HMGB1
R-HSA-5250913	Positive epigenetic regulation of rRNA expression	2.97	2.45e-03	1.99e-02	9/40	HIST2H2AC; H3F3A; H2AFZ; DEK; HIST1H4C; ACTB; H2AFV; POLR2L; H3F3B
R-HSA-5663220	RHO GTPases Activate Formins	2.88	2.26e-04	2.83e-03	14/64	NUDC; RPS27; CENPF; MAD2L1; ACTB; TUBB4B; TUBA1B; TUBA1C; EVL; PFN1; SKA2; ACTG1; NDC80; CENPM
R-HSA-68875	Mitotic Prophase	2.86	4.18e-04	4.96e-03	13/60	HIST2H2AC; H3F3A; SMC4; H2AFZ; LMNB1; HIST1H4C; H2AFV; SMC2; SET; BANF1; TMPO; VRK1; H3F3B
R-HSA-2682334	EPH-Ephrin signaling	2.85	5.50e-03	3.69e-02	8/37	ARPC5; ACTR3; ARPC2; ACTB; ARPC1B; CFL1; MYL6; ACTG1
R-HSA-2559583	Cellular Senescence	2.81	2.48e-05	4.57e-04	19/89	HIST2H2AC; H3F3A; RPS27A; H2AFZ; LMNB1; HIST1H1C; HIST1H4C; HIST1H1E; HIST1H1D; HIST1H1B; H2AFV; EZH2; TXN; CDK4; TFDP1; H3F3B; ANAPC11; UBE2C; UBA52
R-HSA-427413	NoRC negatively regulates rRNA expression	2.70	7.67e-03	4.72e-02	8/39	HIST2H2AC; H3F3A; H2AFZ; HIST1H4C; H2AFV; POLR2L; H3F3B; DNMT1
R-HSA-2500257	Resolution of Sister Chromatid Cohesion	2.68	1.26e-03	1.24e-02	12/59	NUDC; RPS27; CENPF; MAD2L1; SMC1A; RAD21; TUBB4B; TUBA1B; TUBA1C; SKA2; NDC80; CENPM
R-HSA-2029480	Fcgamma receptor (FCGR) dependent phagocytosis	2.64	5.69e-03	3.79e-02	9/45	ARPC5; ACTR3; ARPC2; HSP90AB1; ACTB; ARPC1B; CFL1; HSP90AA1; ACTG1
R-HSA-9018519	Estrogen-dependent gene expression	2.60	1.09e-03	1.14e-02	13/66	HIST2H2AC; H3F3A; H2AFZ; HIST1H4C; HSP90AB1; H2AFV; SMC1A; RAD21; POLR2L; PTGES3; HSP90AA1; KPNA2; H3F3B
R-HSA-8852276	The role of GTSE1 in G2/M progression after G2 checkpoint	2.59	2.68e-03	2.10e-02	11/56	RPS27A; HSP90AB1; TUBB4B; PSMC3; TUBA1B; TUBA1C; PSME2; HSP90AA1; PSMB3; PSMA7; UBA52
R-HSA-2555396	Mitotic Metaphase and Anaphase	2.55	7.94e-06	1.56e-04	25/129	NUDC; RPS27; CENPF; RPS27A; MAD2L1; LMNB1; PTTG1; SMC1A; RAD21; TUBB4B; PSMC3; BANF1; TUBA1B; TUBA1C; TMPO; PSME2; VRK1; PSMB3; SKA2; ANAPC11; NDC80; UBE2C; PSMA7; UBA52; CENPM
R-HSA-68882	Mitotic Anaphase	2.55	7.94e-06	1.56e-04	25/129	NUDC; RPS27; CENPF; RPS27A; MAD2L1; LMNB1; PTTG1; SMC1A; RAD21; TUBB4B; PSMC3; BANF1; TUBA1B; TUBA1C; TMPO; PSME2; VRK1; PSMB3; SKA2; ANAPC11; NDC80; UBE2C; PSMA7; UBA52; CENPM
R-HSA-194315	Signaling by Rho GTPases	2.55	1.76e-07	4.13e-06	34/176	NUDC; HIST2H2AC; RPS27; ARPC5; CENPF; H3F3A; YWHAQ; CALM2; ACTR3; ARPC2; H2AFZ; MAD2L1; HIST1H4C; ACTB; H2AFV; ARPC1B; FLNA; TUBB4B; CFL1; ARHGDIB; TUBA1B; TUBA1C; MYL6; CALM1; EVL; YWHAE; PFN1; SKA2; H3F3B; ACTG1; NDC80; CALM3; YWHAH; CENPM
R-HSA-8939236	RUNX1 regulates transcription of genes involved in differentiation of HSCs	2.51	2.28e-03	1.92e-02	12/63	HIST2H2AC; H3F3A; RPS27A; H2AFZ; HIST1H4C; H2AFV; PSMC3; PSME2; PSMB3; H3F3B; PSMA7; UBA52
R-HSA-69206	G1/S Transition	2.47	7.92e-04	8.92e-03	15/80	CKS1B; RPS27A; DHFR; MCM3; RPA3; MCM7; PSMC3; CDK4; TFDP1; PSME2; PSMB3; TYMS; PCNA; PSMA7; UBA52
R-HSA-5628897	TP53 Regulates Metabolic Genes	2.47	2.62e-03	2.10e-02	12/64	PRDX1; YWHAQ; CYCS; COX7B; TXN; COX8A; COX6A1; YWHAE; PRDX2; YWHAH; MT-CO1; MT-CO3
R-HSA-8939211	ESR-mediated signaling	2.45	1.93e-03	1.71e-02	13/70	HIST2H2AC; H3F3A; H2AFZ; HIST1H4C; HSP90AB1; H2AFV; SMC1A; RAD21; POLR2L; PTGES3; HSP90AA1; KPNA2; H3F3B
R-HSA-69278	Cell Cycle, Mitotic	2.43	5.39e-10	1.37e-08	51/277	NUDC; HIST2H2AC; RPS27; CKS1B; CENPF; H3F3A; RPS27A; SMC4; H2AFZ; MAD2L1; DHFR; LMNB1; PTTG1; HIST1H4C; TUBB; HSP90AB1; MCM3; RPA3; POLD2; H2AFV; RFC2; MCM7; SMC1A; RAD21; SMC2; SET; TUBB4B; PSMC3; BANF1; TUBA1B; TUBA1C; CDK4; TMPO; TFDP1; PSME2; VRK1; HSP90AA1; YWHAE; PSMB3; TOP2A; SKA2; H3F3B; ANAPC11; TYMS; NDC80; PCNA; TPX2; UBE2C; PSMA7; UBA52; CENPM
R-HSA-69242	S Phase	2.41	2.30e-04	2.83e-03	19/104	CKS1B; RPS27A; MCM3; RPA3; POLD2; RFC2; MCM7; SMC1A; RAD21; PSMC3; CDK4; TFDP1; PSME2; PSMB3; ANAPC11; PCNA; UBE2C; PSMA7; UBA52
R-HSA-453279	Mitotic G1-G1/S phases	2.37	8.63e-04	9.36e-03	16/89	CKS1B; RPS27A; DHFR; MCM3; RPA3; MCM7; PSMC3; CDK4; TFDP1; PSME2; PSMB3; TOP2A; TYMS; PCNA; PSMA7; UBA52
R-HSA-69239	Synthesis of DNA	2.37	1.83e-03	1.70e-02	14/78	RPS27A; MCM3; RPA3; POLD2; RFC2; MCM7; PSMC3; PSME2; PSMB3; ANAPC11; PCNA; UBE2C; PSMA7; UBA52
R-HSA-212165	Epigenetic regulation of gene expression	2.33	4.43e-03	3.15e-02	12/68	HIST2H2AC; H3F3A; H2AFZ; DEK; HIST1H4C; ACTB; H2AFV; EZH2; PHF19; POLR2L; H3F3B; DNMT1
R-HSA-2467813	Separation of Sister Chromatids	2.31	2.03e-04	2.59e-03	21/120	NUDC; RPS27; CENPF; RPS27A; MAD2L1; PTTG1; SMC1A; RAD21; TUBB4B; PSMC3; TUBA1B; TUBA1C; PSME2; PSMB3; SKA2; ANAPC11; NDC80; UBE2C; PSMA7; UBA52; CENPM
R-HSA-69306	DNA Replication	2.31	2.35e-03	1.96e-02	14/80	RPS27A; MCM3; RPA3; POLD2; RFC2; MCM7; PSMC3; PSME2; PSMB3; ANAPC11; PCNA; UBE2C; PSMA7; UBA52
R-HSA-68886	M Phase	2.25	1.31e-06	2.94e-05	37/217	NUDC; HIST2H2AC; RPS27; CENPF; H3F3A; RPS27A; SMC4; H2AFZ; MAD2L1; LMNB1; PTTG1; HIST1H4C; TUBB; H2AFV; SMC1A; RAD21; SMC2; SET; TUBB4B; PSMC3; BANF1; TUBA1B; TUBA1C; TMPO; PSME2; VRK1; HSP90AA1; YWHAE; PSMB3; SKA2; H3F3B; ANAPC11; NDC80; UBE2C; PSMA7; UBA52; CENPM
R-HSA-1640170	Cell Cycle	2.24	1.70e-09	4.20e-08	56/330	NUDC; HIST2H2AC; RPS27; CKS1B; CENPF; H3F3A; YWHAQ; RPS27A; SMC4; WHSC1; H2AFZ; MAD2L1; DHFR; LMNB1; PTTG1; NHP2; HIST1H4C; TUBB; HSP90AB1; MCM3; RPA3; POLD2; H2AFV; RFC2; MCM7; SMC1A; RAD21; SMC2; SET; TUBB4B; PSMC3; BANF1; TUBA1B; TUBA1C; CDK4; TMPO; TFDP1; PSME2; VRK1; HSP90AA1; YWHAE; PSMB3; TOP2A; SKA2; H3F3B; ANAPC11; STRA13; TYMS; NDC80; PCNA; TPX2; UBE2C; PSMA7; UBA52; YWHAH; CENPM
R-HSA-9006931	Signaling by Nuclear Receptors	2.22	3.35e-03	2.51e-02	14/83	HIST2H2AC; H3F3A; H2AFZ; HIST1H4C; HSP90AB1; H2AFV; SMC1A; FABP5; RAD21; POLR2L; PTGES3; HSP90AA1; KPNA2; H3F3B
R-HSA-69481	G2/M Checkpoints	2.22	2.44e-03	1.99e-02	15/89	YWHAQ; RPS27A; WHSC1; HIST1H4C; MCM3; RPA3; RFC2; MCM7; PSMC3; PSME2; YWHAE; PSMB3; PSMA7; UBA52; YWHAH
R-HSA-68877	Mitotic Prometaphase	2.18	1.62e-03	1.53e-02	17/103	NUDC; RPS27; CENPF; SMC4; MAD2L1; TUBB; SMC1A; RAD21; SMC2; TUBB4B; TUBA1B; TUBA1C; HSP90AA1; YWHAE; SKA2; NDC80; CENPM
R-HSA-163200	Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.	2.14	1.47e-03	1.41e-02	18/111	NDUFS5; ATP5G3; NDUFS6; UQCRQ; CYCS; ATP5J2; NDUFB2; COX7B; UQCRB; COX8A; COX6A1; ATP5G1; ATP5J; MT-ND2; MT-CO1; MT-ATP6; MT-CO3; MT-CYB
R-HSA-69620	Cell Cycle Checkpoints	2.08	3.68e-04	4.44e-03	24/152	NUDC; RPS27; CENPF; YWHAQ; RPS27A; WHSC1; MAD2L1; HIST1H4C; MCM3; RPA3; RFC2; MCM7; PSMC3; PSME2; YWHAE; PSMB3; SKA2; ANAPC11; NDC80; UBE2C; PSMA7; UBA52; YWHAH; CENPM
R-HSA-2262752	Cellular responses to stress	2.05	7.22e-06	1.53e-04	39/251	PRDX1; HIST2H2AC; H3F3A; RPS27A; H2AFZ; LMNB1; ATOX1; HIST1H1C; HIST1H4C; HIST1H1E; HIST1H1D; HIST1H1B; HSP90AB1; EEF1A1; RPA3; CYCS; H2AFV; EZH2; TXN; TUBB4B; PSMC3; GSTP1; HSPA8; TUBA1B; TUBA1C; PTGES3; CDK4; TFDP1; PSME2; HSP90AA1; TCEB2; YWHAE; PSMB3; H3F3B; ANAPC11; UBE2C; PSMA7; PRDX2; UBA52
R-HSA-109581	Apoptosis	2.05	2.44e-03	1.99e-02	18/116	YWHAQ; RPS27A; HMGB2; LMNB1; HIST1H1C; HIST1H1E; HIST1H1D; HIST1H1B; CYCS; PSMC3; HMGB1; TFDP1; PSME2; YWHAE; PSMB3; PSMA7; UBA52; YWHAH
R-HSA-5357801	Programmed Cell Death	2.03	2.69e-03	2.10e-02	18/117	YWHAQ; RPS27A; HMGB2; LMNB1; HIST1H1C; HIST1H1E; HIST1H1D; HIST1H1B; CYCS; PSMC3; HMGB1; TFDP1; PSME2; YWHAE; PSMB3; PSMA7; UBA52; YWHAH

Factor 3 : 46 significant Reactome pathways

GeneSet	description	enrichRatio	pValue	FDR	GeneRatio	geneSymbols
R-HSA-216083	Integrin cell surface interactions	10.10	2.05e-09	5.93e-07	10/14	ITGA6; ITGA4; CD47; ITGA1; CD44; ITGB1; ITGB7; ITGAL; ITGAE; ICAM2
R-HSA-445355	Smooth Muscle Contraction	7.86	6.95e-08	5.59e-06	10/18	MYL5; ITGA1; ANXA1; VCL; MYL6B; PXN; CALM1; ANXA2; MYL12A
R-HSA-2142753	Arachidonic acid metabolism	7.07	3.19e-04	7.09e-03	5/10	CYP1B1; HPGD; ALOX5AP; DPEP2; GPX4
R-HSA-8876725	Protein methylation	7.07	7.58e-05	2.05e-03	6/12	HSPA8; CALM1; RPS2; EEF2; ETFB
R-HSA-418360	Platelet calcium homeostasis	6.43	5.51e-04	1.15e-02	5/11	ORAI2; ATP2B1; ORAI1; CALM1
R-HSA-198933	Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell	5.59	1.31e-09	5.66e-07	17/43	SLAMF7; CD8B; ITGA4; HLA-A; HLA-E; HLA-C; HLA-B; SH2D1A; NPDC1; CD3D; ITGB1; KLRB1; ITGB7; B2M; ITGAL; ICAM2; CD226
R-HSA-397014	Muscle contraction	5.44	1.99e-08	2.47e-06	15/39	TTN; MYL5; ITGA1; ORAI2; ANXA1; VIM; VCL; MYL6B; ATP2B1; PXN; ORAI1; CALM1; ANXA2; MYL12A
R-HSA-373076	Class A/1 (Rhodopsin-like receptors)	5.30	1.96e-05	6.74e-04	9/24	S1PR1; CXCR4; ANXA1; GPR183; PTGER2; GPR68; CCL5; CCR7; S1PR4
R-HSA-446728	Cell junction organization	5.05	2.00e-03	3.47e-02	5/14	LIMS1; ITGA6; FLNA; ITGB1; PXN
R-HSA-1474244	Extracellular matrix organization	4.83	3.44e-07	2.13e-05	14/41	CAPN2; ITGA6; ITGA4; CD47; ITGA1; CAST; TIMP1; CD44; ITGB1; ITGB7; ITGAL; ITGAE; ICAM2; CAPN12
R-HSA-6785807	Interleukin-4 and Interleukin-13 signaling	4.58	1.18e-05	4.46e-04	11/34	JAK1; S1PR1; STAT1; TIMP1; MYC; ANXA1; HSPA8; VIM; ITGB1; HIF1A; BATF
R-HSA-500792	GPCR ligand binding	4.42	4.20e-05	1.26e-03	10/32	S1PR1; CD55; CXCR4; ANXA1; GPR183; PTGER2; GPR68; CCL5; CCR7; S1PR4
R-HSA-202733	Cell surface interactions at the vascular wall	4.38	3.26e-06	1.28e-04	13/42	CD2; FCER1G; ITGA6; ITGA4; CD47; CD74; DOK2; CD44; ITGB1; SELPLG; ITGAL; GLG1; SIRPG
R-HSA-909733	Interferon alpha/beta signaling	3.98	2.54e-04	5.94e-03	9/32	JAK1; STAT1; HLA-A; HLA-E; HLA-C; HLA-B; ISG20; SAMHD1; IFNAR2
R-HSA-156902	Peptide chain elongation	3.87	6.69e-09	1.45e-06	23/84	RPL11; RPL37A; RPSA; RPL14; RPL9; RPS18; RPS4X; RPL36A; RPS20; RPL12; RPL7A; RPS25; RPS24; RPL6; RPS29; RPLP1; RPS2; RPS15A; RPL26; RPL23; EEF2; RPL13A; RPL28
R-HSA-877300	Interferon gamma signaling	3.86	3.30e-05	1.06e-03	12/44	JAK1; STAT1; HLA-A; HLA-E; HLA-C; HLA-B; HLA-DRA; HLA-DQA1; HLA-DPB1; CD44; B2M; MT2A
R-HSA-156842	Eukaryotic Translation Elongation	3.74	1.40e-08	2.43e-06	23/87	RPL11; RPL37A; RPSA; RPL14; RPL9; RPS18; RPS4X; RPL36A; RPS20; RPL12; RPL7A; RPS25; RPS24; RPL6; RPS29; RPLP1; RPS2; RPS15A; RPL26; RPL23; EEF2; RPL13A; RPL28
R-HSA-192823	Viral mRNA Translation	3.70	3.55e-08	3.85e-06	22/84	RPL11; RPL37A; RPSA; RPL14; RPL9; RPS18; RPS4X; RPL36A; RPS20; RPL12; RPL7A; RPS25; RPS24; RPL6; RPS29; RPLP1; RPS2; RPS15A; RPL26; RPL23; RPL13A; RPL28
R-HSA-975956	Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)	3.70	1.78e-08	2.47e-06	23/88	RPL11; RPL37A; RPSA; RPL14; RPL9; RPS18; RPS4X; RPL36A; RPS20; PABPC1; RPL12; RPL7A; RPS25; RPS24; RPL6; RPS29; RPLP1; RPS2; RPS15A; RPL26; RPL23; RPL13A; RPL28
R-HSA-2408557	Selenocysteine synthesis	3.66	4.49e-08	4.33e-06	22/85	RPL11; RPL37A; RPSA; RPL14; RPL9; RPS18; RPS4X; RPL36A; RPS20; RPL12; RPL7A; RPS25; RPS24; RPL6; RPS29; RPLP1; RPS2; RPS15A; RPL26; RPL23; RPL13A; RPL28
R-HSA-72764	Eukaryotic Translation Termination	3.58	7.10e-08	5.59e-06	22/87	RPL11; RPL37A; RPSA; RPL14; RPL9; RPS18; RPS4X; RPL36A; RPS20; RPL12; RPL7A; RPS25; RPS24; RPL6; RPS29; RPLP1; RPS2; RPS15A; RPL26; RPL23; RPL13A; RPL28
R-HSA-72689	Formation of a pool of free 40S subunits	3.42	8.49e-08	6.13e-06	23/95	RPL11; RPL37A; RPSA; RPL14; RPL9; RPS18; RPS4X; RPL36A; RPS20; RPL12; RPL7A; RPS25; RPS24; EIF3A; RPL6; RPS29; RPLP1; RPS2; RPS15A; RPL26; RPL23; RPL13A; RPL28
R-HSA-156827	L13a-mediated translational silencing of Ceruloplasmin expression	3.23	1.43e-07	9.53e-06	24/105	RPL11; RPL37A; RPSA; RPL14; RPL9; RPS18; RPS4X; RPL36A; RPS20; PABPC1; RPL12; RPL7A; RPS25; RPS24; EIF3A; RPL6; RPS29; RPLP1; RPS2; RPS15A; RPL26; RPL23; RPL13A; RPL28
R-HSA-2408522	Selenoamino acid metabolism	3.14	8.20e-07	3.56e-05	22/99	RPL11; RPL37A; RPSA; RPL14; RPL9; RPS18; RPS4X; RPL36A; RPS20; RPL12; RPL7A; RPS25; RPS24; RPL6; RPS29; RPLP1; RPS2; RPS15A; RPL26; RPL23; RPL13A; RPL28
R-HSA-76005	Response to elevated platelet cytosolic Ca2+	3.14	2.83e-04	6.47e-03	12/54	TTN; ANXA5; TMSB4X; TIMP1; FLNA; CTSW; SRGN; VCL; CALM1; PRKCB; PFN1
R-HSA-114608	Platelet degranulation	3.11	5.57e-04	1.15e-02	11/50	TTN; ANXA5; TMSB4X; TIMP1; FLNA; CTSW; SRGN; VCL; CALM1; PFN1
R-HSA-927802	Nonsense-Mediated Decay (NMD)	3.10	5.99e-07	2.89e-05	23/105	RPL11; RPL37A; RPSA; RPL14; RPL9; RPS18; RPS4X; RPL36A; RPS20; PABPC1; RPL12; RPL7A; RPS25; RPS24; RPL6; RPS29; RPLP1; RPS2; RPS15A; RPL26; RPL23; RPL13A; RPL28
R-HSA-975957	Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)	3.10	5.99e-07	2.89e-05	23/105	RPL11; RPL37A; RPSA; RPL14; RPL9; RPS18; RPS4X; RPL36A; RPS20; PABPC1; RPL12; RPL7A; RPS25; RPS24; RPL6; RPS29; RPLP1; RPS2; RPS15A; RPL26; RPL23; RPL13A; RPL28
R-HSA-72706	GTP hydrolysis and joining of the 60S ribosomal subunit	3.07	7.17e-07	3.27e-05	23/106	RPL11; RPL37A; RPSA; RPL14; RPL9; RPS18; RPS4X; RPL36A; RPS20; RPL12; RPL7A; RPS25; RPS24; EIF3A; RPL6; RPS29; RPLP1; RPS2; RPS15A; RPL26; RPL23; RPL13A; RPL28
R-HSA-72613	Eukaryotic Translation Initiation	3.03	5.19e-07	2.81e-05	24/112	RPL11; RPL37A; RPSA; RPL14; RPL9; RPS18; RPS4X; RPL36A; RPS20; PABPC1; RPL12; RPL7A; RPS25; RPS24; EIF3A; RPL6; RPS29; RPLP1; RPS2; RPS15A; RPL26; RPL23; RPL13A; RPL28
R-HSA-72737	Cap-dependent Translation Initiation	3.03	5.19e-07	2.81e-05	24/112	RPL11; RPL37A; RPSA; RPL14; RPL9; RPS18; RPS4X; RPL36A; RPS20; PABPC1; RPL12; RPL7A; RPS25; RPS24; EIF3A; RPL6; RPS29; RPLP1; RPS2; RPS15A; RPL26; RPL23; RPL13A; RPL28
R-HSA-72695	Formation of the ternary complex, and subsequently, the 43S complex	2.95	1.55e-03	2.80e-02	10/48	RPSA; RPS18; RPS4X; RPS20; RPS25; RPS24; EIF3A; RPS29; RPS2; RPS15A
R-HSA-1799339	SRP-dependent cotranslational protein targeting to membrane	2.94	2.80e-06	1.16e-04	22/106	RPL11; RPL37A; RPSA; RPL14; RPL9; RPS18; RPS4X; RPL36A; RPS20; RPL12; RPL7A; RPS25; RPS24; RPL6; RPS29; RPLP1; RPS2; RPS15A; RPL26; RPL23; RPL13A; RPL28
R-HSA-72649	Translation initiation complex formation	2.83	1.30e-03	2.45e-02	11/55	RPSA; RPS18; RPS4X; RPS20; PABPC1; RPS25; RPS24; EIF3A; RPS29; RPS2; RPS15A
R-HSA-109582	Hemostasis	2.79	8.04e-10	5.66e-07	40/203	CD2; S100A10; FCER1G; H3F3A; ITGA6; TTN; ITGA4; DGKD; CD47; ANXA5; ITGA1; KIF2A; CD74; SERPINB6; MYB; ORAI2; TMSB4X; TIMP1; FLNA; DOK2; GNAQ; CD44; RASGRP2; CTSW; ITGB1; SRGN; VCL; ATP2B1; SELPLG; ORAI1; CALM1; ANXA2; PRKCB; LAT; ITGAL; GLG1; ARRB2; PFN1; SIRPG
R-HSA-72662	Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S	2.78	1.52e-03	2.80e-02	11/56	RPSA; RPS18; RPS4X; RPS20; PABPC1; RPS25; RPS24; EIF3A; RPS29; RPS2; RPS15A
R-HSA-418594	G alpha (i) signalling events	2.74	6.51e-04	1.31e-02	13/67	DHRS3; S1PR1; RGS1; CXCR4; GPSM3; ANXA1; RGS10; GPR183; CALM1; CCL5; CCR7; S1PR4
R-HSA-168273	Influenza Viral RNA Transcription and Replication	2.62	2.02e-05	6.74e-04	22/119	RPL11; RPL37A; RPSA; RPL14; RPL9; RPS18; RPS4X; RPL36A; RPS20; RPL12; RPL7A; RPS25; RPS24; RPL6; RPS29; RPLP1; RPS2; RPS15A; RPL26; RPL23; RPL13A; RPL28
R-HSA-372790	Signaling by GPCR	2.60	1.41e-05	5.10e-04	23/125	DHRS3; S1PR1; RHOC; RGS1; CD55; CXCR4; DGKD; GRK6; GPSM3; ANXA1; GNAQ; RASGRP2; RGS10; GPR183; PTGER2; CALM1; GPR68; PRKCB; ARRB2; CCL5; CCR7; S1PR4
R-HSA-388396	GPCR downstream signalling	2.53	3.47e-05	1.07e-03	22/123	DHRS3; S1PR1; RHOC; RGS1; CXCR4; DGKD; GRK6; GPSM3; ANXA1; GNAQ; RASGRP2; RGS10; GPR183; PTGER2; CALM1; GPR68; PRKCB; ARRB2; CCL5; CCR7; S1PR4
R-HSA-168255	Influenza Life Cycle	2.43	6.55e-05	1.83e-03	22/128	RPL11; RPL37A; RPSA; RPL14; RPL9; RPS18; RPS4X; RPL36A; RPS20; RPL12; RPL7A; RPS25; RPS24; RPL6; RPS29; RPLP1; RPS2; RPS15A; RPL26; RPL23; RPL13A; RPL28
R-HSA-76002	Platelet activation, signaling and aggregation	2.40	3.58e-04	7.77e-03	18/106	FCER1G; TTN; DGKD; ANXA5; TMSB4X; TIMP1; FLNA; GNAQ; RASGRP2; CTSW; SRGN; VCL; CALM1; PRKCB; LAT; ARRB2; PFN1
R-HSA-168254	Influenza Infection	2.37	6.52e-05	1.83e-03	23/137	RPL11; RPL37A; RPSA; RPL14; RPL9; RPS18; SLC25A6; RPS4X; RPL36A; RPS20; RPL12; RPL7A; RPS25; RPS24; RPL6; RPS29; RPLP1; RPS2; RPS15A; RPL26; RPL23; RPL13A; RPL28
R-HSA-9010553	Regulation of expression of SLITs and ROBOs	2.21	1.98e-04	4.77e-03	23/147	RPL11; RPL37A; RPSA; RPL14; RPL9; RPS18; RPS4X; RPL36A; RPS20; PABPC1; RPL12; RPL7A; RPS25; RPS24; RPL6; RPS29; RPLP1; RPS2; RPS15A; RPL26; RPL23; RPL13A; RPL28
R-HSA-376176	Signaling by ROBO receptors	2.20	8.17e-05	2.15e-03	26/167	RPL11; CXCR4; RPL37A; SRGAP3; RPSA; RPL14; RPL9; RPS18; RPS4X; RPL36A; RPS20; PABPC1; RPL12; RPL7A; RPS25; RPS24; RPL6; RPS29; RPLP1; RPS2; RPS15A; PFN1; RPL26; RPL23; RPL13A; RPL28
R-HSA-6791226	Major pathway of rRNA processing in the nucleolus and cytosol	2.06	7.59e-04	1.50e-02	22/151	RPL11; RPL37A; RPSA; RPL14; RPL9; RPS18; RPS4X; RPL36A; RPS20; RPL12; RPL7A; RPS25; RPS24; RPL6; RPS29; RPLP1; RPS2; RPS15A; RPL26; RPL23; RPL13A; RPL28

Factor 4 : 10 significant Reactome pathways

GeneSet	description	enrichRatio	pValue	FDR	GeneRatio	geneSymbols
R-HSA-983170	Antigen Presentation: Folding, assembly and peptide loading of class I MHC	66.9	2.05e-07	0.000178	4/20	HLA-A; HLA-C; HLA-B; B2M
R-HSA-2559585	Oncogene Induced Senescence	47.8	2.57e-05	0.003185	3/21	MDM4; UBC; TNRC6B
R-HSA-909733	Interferon alpha/beta signaling	31.3	9.42e-05	0.010208	3/32	HLA-A; HLA-C; HLA-B
R-HSA-198933	Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell	31.1	5.04e-06	0.000960	4/43	HLA-A; HLA-C; HLA-B; B2M
R-HSA-877300	Interferon gamma signaling	30.4	5.54e-06	0.000960	4/44	HLA-A; HLA-C; HLA-B; B2M
R-HSA-1236974	ER-Phagosome pathway	23.9	9.14e-07	0.000374	5/70	HLA-A; HLA-C; HLA-B; UBC; B2M
R-HSA-1236975	Antigen processing-Cross presentation	22.3	1.30e-06	0.000374	5/75	HLA-A; HLA-C; HLA-B; UBC; B2M
R-HSA-2559580	Oxidative Stress Induced Senescence	21.8	2.82e-04	0.024427	3/46	MDM4; UBC; TNRC6B
R-HSA-913531	Interferon Signaling	15.6	7.63e-06	0.001103	5/107	HLA-A; HLA-C; HLA-B; UBC; B2M
R-HSA-983169	Class I MHC mediated antigen processing & presentation	7.7	2.35e-04	0.022680	5/217	HLA-A; HLA-C; HLA-B; UBC; B2M

Factor 5 : 40 significant Reactome pathways

GeneSet	description	enrichRatio	pValue	FDR	GeneRatio	geneSymbols
R-HSA-156902	Peptide chain elongation	23.00	0.00e+00	0.00e+00	73/84	RPL22; RPL11; RPS8; RPL5; RPS7; RPS27A; RPL31; RPL37A; RPL32; RPL15; RPSA; RPL14; RPL29; RPL24; RPL35A; RPL9; RPL34; RPS3A; RPL37; RPS23; RPS14; RPS18; RPS10; RPL10A; EEF1A1; RPS12; RPS4X; RPL36A; RPL39; RPL10; RPS20; RPL7; RPL30; RPL8; RPS6; RPL35; RPL12; RPL7A; RPLP2; RPL27A; RPS13; RPS3; RPS25; RPS24; RPL41; RPL6; RPLP0; RPL21; RPS29; RPL4; RPLP1; RPS17; RPS2; RPL13; RPL26; RPL23A; RPL19; RPL27; RPL38; RPS21; RPS15; EEF2; RPL36; RPS28; RPL18A; RPS16; RPL18; RPL13A; RPS11; RPS9; RPL28; RPS5; RPL3
R-HSA-156842	Eukaryotic Translation Elongation	22.50	0.00e+00	0.00e+00	74/87	RPL22; RPL11; RPS8; RPL5; RPS7; RPS27A; RPL31; EEF1B2; RPL37A; RPL32; RPL15; RPSA; RPL14; RPL29; RPL24; RPL35A; RPL9; RPL34; RPS3A; RPL37; RPS23; RPS14; RPS18; RPS10; RPL10A; EEF1A1; RPS12; RPS4X; RPL36A; RPL39; RPL10; RPS20; RPL7; RPL30; RPL8; RPS6; RPL35; RPL12; RPL7A; RPLP2; RPL27A; RPS13; RPS3; RPS25; RPS24; RPL41; RPL6; RPLP0; RPL21; RPS29; RPL4; RPLP1; RPS17; RPS2; RPL13; RPL26; RPL23A; RPL19; RPL27; RPL38; RPS21; RPS15; EEF2; RPL36; RPS28; RPL18A; RPS16; RPL18; RPL13A; RPS11; RPS9; RPL28; RPS5; RPL3
R-HSA-192823	Viral mRNA Translation	22.40	0.00e+00	0.00e+00	71/84	RPL22; RPL11; RPS8; RPL5; RPS7; RPS27A; RPL31; RPL37A; RPL32; RPL15; RPSA; RPL14; RPL29; RPL24; RPL35A; RPL9; RPL34; RPS3A; RPL37; RPS23; RPS14; RPS18; RPS10; RPL10A; RPS12; RPS4X; RPL36A; RPL39; RPL10; RPS20; RPL7; RPL30; RPL8; RPS6; RPL35; RPL12; RPL7A; RPLP2; RPL27A; RPS13; RPS3; RPS25; RPS24; RPL41; RPL6; RPLP0; RPL21; RPS29; RPL4; RPLP1; RPS17; RPS2; RPL13; RPL26; RPL23A; RPL19; RPL27; RPL38; RPS21; RPS15; RPL36; RPS28; RPL18A; RPS16; RPL18; RPL13A; RPS11; RPS9; RPL28; RPS5; RPL3
R-HSA-2408557	Selenocysteine synthesis	22.10	0.00e+00	0.00e+00	71/85	RPL22; RPL11; RPS8; RPL5; RPS7; RPS27A; RPL31; RPL37A; RPL32; RPL15; RPSA; RPL14; RPL29; RPL24; RPL35A; RPL9; RPL34; RPS3A; RPL37; RPS23; RPS14; RPS18; RPS10; RPL10A; RPS12; RPS4X; RPL36A; RPL39; RPL10; RPS20; RPL7; RPL30; RPL8; RPS6; RPL35; RPL12; RPL7A; RPLP2; RPL27A; RPS13; RPS3; RPS25; RPS24; RPL41; RPL6; RPLP0; RPL21; RPS29; RPL4; RPLP1; RPS17; RPS2; RPL13; RPL26; RPL23A; RPL19; RPL27; RPL38; RPS21; RPS15; RPL36; RPS28; RPL18A; RPS16; RPL18; RPL13A; RPS11; RPS9; RPL28; RPS5; RPL3
R-HSA-975956	Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)	21.60	0.00e+00	0.00e+00	72/88	RPL22; RPL11; RPS8; RPL5; RPS7; RPS27A; RPL31; RPL37A; RPL32; RPL15; RPSA; RPL14; RPL29; RPL24; RPL35A; RPL9; RPL34; RPS3A; RPL37; RPS23; RPS14; RPS18; RPS10; RPL10A; RPS12; RPS4X; RPL36A; RPL39; RPL10; RPS20; RPL7; RPL30; PABPC1; RPL8; RPS6; RPL35; RPL12; RPL7A; RPLP2; RPL27A; RPS13; RPS3; RPS25; RPS24; RPL41; RPL6; RPLP0; RPL21; RPS29; RPL4; RPLP1; RPS17; RPS2; RPL13; RPL26; RPL23A; RPL19; RPL27; RPL38; RPS21; RPS15; RPL36; RPS28; RPL18A; RPS16; RPL18; RPL13A; RPS11; RPS9; RPL28; RPS5; RPL3
R-HSA-72764	Eukaryotic Translation Termination	21.60	0.00e+00	0.00e+00	71/87	RPL22; RPL11; RPS8; RPL5; RPS7; RPS27A; RPL31; RPL37A; RPL32; RPL15; RPSA; RPL14; RPL29; RPL24; RPL35A; RPL9; RPL34; RPS3A; RPL37; RPS23; RPS14; RPS18; RPS10; RPL10A; RPS12; RPS4X; RPL36A; RPL39; RPL10; RPS20; RPL7; RPL30; RPL8; RPS6; RPL35; RPL12; RPL7A; RPLP2; RPL27A; RPS13; RPS3; RPS25; RPS24; RPL41; RPL6; RPLP0; RPL21; RPS29; RPL4; RPLP1; RPS17; RPS2; RPL13; RPL26; RPL23A; RPL19; RPL27; RPL38; RPS21; RPS15; RPL36; RPS28; RPL18A; RPS16; RPL18; RPL13A; RPS11; RPS9; RPL28; RPS5; RPL3
R-HSA-72689	Formation of a pool of free 40S subunits	20.60	0.00e+00	0.00e+00	74/95	RPL22; RPL11; RPS8; RPL5; RPS7; RPS27A; RPL31; RPL37A; RPL32; RPL15; RPSA; RPL14; RPL29; RPL24; RPL35A; RPL9; RPL34; RPS3A; RPL37; RPS23; RPS14; RPS18; RPS10; RPL10A; RPS12; RPS4X; RPL36A; RPL39; RPL10; RPS20; RPL7; RPL30; EIF3E; EIF3H; RPL8; RPS6; RPL35; RPL12; RPL7A; RPLP2; RPL27A; RPS13; RPS3; RPS25; RPS24; RPL41; RPL6; RPLP0; RPL21; RPS29; RPL4; RPLP1; RPS17; RPS2; RPL13; RPL26; RPL23A; RPL19; RPL27; RPL38; RPS21; RPS15; RPL36; RPS28; RPL18A; RPS16; RPL18; RPL13A; RPS11; RPS9; RPL28; RPS5; EIF3L; RPL3
R-HSA-2408522	Selenoamino acid metabolism	19.00	0.00e+00	0.00e+00	71/99	RPL22; RPL11; RPS8; RPL5; RPS7; RPS27A; RPL31; RPL37A; RPL32; RPL15; RPSA; RPL14; RPL29; RPL24; RPL35A; RPL9; RPL34; RPS3A; RPL37; RPS23; RPS14; RPS18; RPS10; RPL10A; RPS12; RPS4X; RPL36A; RPL39; RPL10; RPS20; RPL7; RPL30; RPL8; RPS6; RPL35; RPL12; RPL7A; RPLP2; RPL27A; RPS13; RPS3; RPS25; RPS24; RPL41; RPL6; RPLP0; RPL21; RPS29; RPL4; RPLP1; RPS17; RPS2; RPL13; RPL26; RPL23A; RPL19; RPL27; RPL38; RPS21; RPS15; RPL36; RPS28; RPL18A; RPS16; RPL18; RPL13A; RPS11; RPS9; RPL28; RPS5; RPL3
R-HSA-156827	L13a-mediated translational silencing of Ceruloplasmin expression	18.90	0.00e+00	0.00e+00	75/105	RPL22; RPL11; RPS8; RPL5; RPS7; RPS27A; RPL31; RPL37A; RPL32; RPL15; RPSA; RPL14; RPL29; RPL24; RPL35A; RPL9; RPL34; RPS3A; RPL37; RPS23; RPS14; RPS18; RPS10; RPL10A; RPS12; RPS4X; RPL36A; RPL39; RPL10; RPS20; RPL7; RPL30; PABPC1; EIF3E; EIF3H; RPL8; RPS6; RPL35; RPL12; RPL7A; RPLP2; RPL27A; RPS13; RPS3; RPS25; RPS24; RPL41; RPL6; RPLP0; RPL21; RPS29; RPL4; RPLP1; RPS17; RPS2; RPL13; RPL26; RPL23A; RPL19; RPL27; RPL38; RPS21; RPS15; RPL36; RPS28; RPL18A; RPS16; RPL18; RPL13A; RPS11; RPS9; RPL28; RPS5; EIF3L; RPL3
R-HSA-72706	GTP hydrolysis and joining of the 60S ribosomal subunit	18.50	0.00e+00	0.00e+00	74/106	RPL22; RPL11; RPS8; RPL5; RPS7; RPS27A; RPL31; RPL37A; RPL32; RPL15; RPSA; RPL14; RPL29; RPL24; RPL35A; RPL9; RPL34; RPS3A; RPL37; RPS23; RPS14; RPS18; RPS10; RPL10A; RPS12; RPS4X; RPL36A; RPL39; RPL10; RPS20; RPL7; RPL30; EIF3E; EIF3H; RPL8; RPS6; RPL35; RPL12; RPL7A; RPLP2; RPL27A; RPS13; RPS3; RPS25; RPS24; RPL41; RPL6; RPLP0; RPL21; RPS29; RPL4; RPLP1; RPS17; RPS2; RPL13; RPL26; RPL23A; RPL19; RPL27; RPL38; RPS21; RPS15; RPL36; RPS28; RPL18A; RPS16; RPL18; RPL13A; RPS11; RPS9; RPL28; RPS5; EIF3L; RPL3
R-HSA-927802	Nonsense-Mediated Decay (NMD)	18.10	0.00e+00	0.00e+00	72/105	RPL22; RPL11; RPS8; RPL5; RPS7; RPS27A; RPL31; RPL37A; RPL32; RPL15; RPSA; RPL14; RPL29; RPL24; RPL35A; RPL9; RPL34; RPS3A; RPL37; RPS23; RPS14; RPS18; RPS10; RPL10A; RPS12; RPS4X; RPL36A; RPL39; RPL10; RPS20; RPL7; RPL30; PABPC1; RPL8; RPS6; RPL35; RPL12; RPL7A; RPLP2; RPL27A; RPS13; RPS3; RPS25; RPS24; RPL41; RPL6; RPLP0; RPL21; RPS29; RPL4; RPLP1; RPS17; RPS2; RPL13; RPL26; RPL23A; RPL19; RPL27; RPL38; RPS21; RPS15; RPL36; RPS28; RPL18A; RPS16; RPL18; RPL13A; RPS11; RPS9; RPL28; RPS5; RPL3
R-HSA-975957	Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)	18.10	0.00e+00	0.00e+00	72/105	RPL22; RPL11; RPS8; RPL5; RPS7; RPS27A; RPL31; RPL37A; RPL32; RPL15; RPSA; RPL14; RPL29; RPL24; RPL35A; RPL9; RPL34; RPS3A; RPL37; RPS23; RPS14; RPS18; RPS10; RPL10A; RPS12; RPS4X; RPL36A; RPL39; RPL10; RPS20; RPL7; RPL30; PABPC1; RPL8; RPS6; RPL35; RPL12; RPL7A; RPLP2; RPL27A; RPS13; RPS3; RPS25; RPS24; RPL41; RPL6; RPLP0; RPL21; RPS29; RPL4; RPLP1; RPS17; RPS2; RPL13; RPL26; RPL23A; RPL19; RPL27; RPL38; RPS21; RPS15; RPL36; RPS28; RPL18A; RPS16; RPL18; RPL13A; RPS11; RPS9; RPL28; RPS5; RPL3
R-HSA-1799339	SRP-dependent cotranslational protein targeting to membrane	17.70	0.00e+00	0.00e+00	71/106	RPL22; RPL11; RPS8; RPL5; RPS7; RPS27A; RPL31; RPL37A; RPL32; RPL15; RPSA; RPL14; RPL29; RPL24; RPL35A; RPL9; RPL34; RPS3A; RPL37; RPS23; RPS14; RPS18; RPS10; RPL10A; RPS12; RPS4X; RPL36A; RPL39; RPL10; RPS20; RPL7; RPL30; RPL8; RPS6; RPL35; RPL12; RPL7A; RPLP2; RPL27A; RPS13; RPS3; RPS25; RPS24; RPL41; RPL6; RPLP0; RPL21; RPS29; RPL4; RPLP1; RPS17; RPS2; RPL13; RPL26; RPL23A; RPL19; RPL27; RPL38; RPS21; RPS15; RPL36; RPS28; RPL18A; RPS16; RPL18; RPL13A; RPS11; RPS9; RPL28; RPS5; RPL3
R-HSA-72613	Eukaryotic Translation Initiation	17.70	0.00e+00	0.00e+00	75/112	RPL22; RPL11; RPS8; RPL5; RPS7; RPS27A; RPL31; RPL37A; RPL32; RPL15; RPSA; RPL14; RPL29; RPL24; RPL35A; RPL9; RPL34; RPS3A; RPL37; RPS23; RPS14; RPS18; RPS10; RPL10A; RPS12; RPS4X; RPL36A; RPL39; RPL10; RPS20; RPL7; RPL30; PABPC1; EIF3E; EIF3H; RPL8; RPS6; RPL35; RPL12; RPL7A; RPLP2; RPL27A; RPS13; RPS3; RPS25; RPS24; RPL41; RPL6; RPLP0; RPL21; RPS29; RPL4; RPLP1; RPS17; RPS2; RPL13; RPL26; RPL23A; RPL19; RPL27; RPL38; RPS21; RPS15; RPL36; RPS28; RPL18A; RPS16; RPL18; RPL13A; RPS11; RPS9; RPL28; RPS5; EIF3L; RPL3
R-HSA-72737	Cap-dependent Translation Initiation	17.70	0.00e+00	0.00e+00	75/112	RPL22; RPL11; RPS8; RPL5; RPS7; RPS27A; RPL31; RPL37A; RPL32; RPL15; RPSA; RPL14; RPL29; RPL24; RPL35A; RPL9; RPL34; RPS3A; RPL37; RPS23; RPS14; RPS18; RPS10; RPL10A; RPS12; RPS4X; RPL36A; RPL39; RPL10; RPS20; RPL7; RPL30; PABPC1; EIF3E; EIF3H; RPL8; RPS6; RPL35; RPL12; RPL7A; RPLP2; RPL27A; RPS13; RPS3; RPS25; RPS24; RPL41; RPL6; RPLP0; RPL21; RPS29; RPL4; RPLP1; RPS17; RPS2; RPL13; RPL26; RPL23A; RPL19; RPL27; RPL38; RPS21; RPS15; RPL36; RPS28; RPL18A; RPS16; RPL18; RPL13A; RPS11; RPS9; RPL28; RPS5; EIF3L; RPL3
R-HSA-72695	Formation of the ternary complex, and subsequently, the 43S complex	16.50	0.00e+00	0.00e+00	30/48	RPS8; RPS7; RPS27A; RPSA; RPS3A; RPS23; RPS14; RPS18; RPS10; RPS12; RPS4X; RPS20; EIF3E; EIF3H; RPS6; RPS13; RPS3; RPS25; RPS24; RPS29; RPS17; RPS2; RPS21; RPS15; RPS28; RPS16; RPS11; RPS9; RPS5; EIF3L
R-HSA-168273	Influenza Viral RNA Transcription and Replication	15.80	0.00e+00	0.00e+00	71/119	RPL22; RPL11; RPS8; RPL5; RPS7; RPS27A; RPL31; RPL37A; RPL32; RPL15; RPSA; RPL14; RPL29; RPL24; RPL35A; RPL9; RPL34; RPS3A; RPL37; RPS23; RPS14; RPS18; RPS10; RPL10A; RPS12; RPS4X; RPL36A; RPL39; RPL10; RPS20; RPL7; RPL30; RPL8; RPS6; RPL35; RPL12; RPL7A; RPLP2; RPL27A; RPS13; RPS3; RPS25; RPS24; RPL41; RPL6; RPLP0; RPL21; RPS29; RPL4; RPLP1; RPS17; RPS2; RPL13; RPL26; RPL23A; RPL19; RPL27; RPL38; RPS21; RPS15; RPL36; RPS28; RPL18A; RPS16; RPL18; RPL13A; RPS11; RPS9; RPL28; RPS5; RPL3
R-HSA-72649	Translation initiation complex formation	14.90	0.00e+00	0.00e+00	31/55	RPS8; RPS7; RPS27A; RPSA; RPS3A; RPS23; RPS14; RPS18; RPS10; RPS12; RPS4X; RPS20; PABPC1; EIF3E; EIF3H; RPS6; RPS13; RPS3; RPS25; RPS24; RPS29; RPS17; RPS2; RPS21; RPS15; RPS28; RPS16; RPS11; RPS9; RPS5; EIF3L
R-HSA-168255	Influenza Life Cycle	14.70	0.00e+00	0.00e+00	71/128	RPL22; RPL11; RPS8; RPL5; RPS7; RPS27A; RPL31; RPL37A; RPL32; RPL15; RPSA; RPL14; RPL29; RPL24; RPL35A; RPL9; RPL34; RPS3A; RPL37; RPS23; RPS14; RPS18; RPS10; RPL10A; RPS12; RPS4X; RPL36A; RPL39; RPL10; RPS20; RPL7; RPL30; RPL8; RPS6; RPL35; RPL12; RPL7A; RPLP2; RPL27A; RPS13; RPS3; RPS25; RPS24; RPL41; RPL6; RPLP0; RPL21; RPS29; RPL4; RPLP1; RPS17; RPS2; RPL13; RPL26; RPL23A; RPL19; RPL27; RPL38; RPS21; RPS15; RPL36; RPS28; RPL18A; RPS16; RPL18; RPL13A; RPS11; RPS9; RPL28; RPS5; RPL3
R-HSA-72662	Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S	14.60	0.00e+00	0.00e+00	31/56	RPS8; RPS7; RPS27A; RPSA; RPS3A; RPS23; RPS14; RPS18; RPS10; RPS12; RPS4X; RPS20; PABPC1; EIF3E; EIF3H; RPS6; RPS13; RPS3; RPS25; RPS24; RPS29; RPS17; RPS2; RPS21; RPS15; RPS28; RPS16; RPS11; RPS9; RPS5; EIF3L
R-HSA-72702	Ribosomal scanning and start codon recognition	14.40	0.00e+00	0.00e+00	30/55	RPS8; RPS7; RPS27A; RPSA; RPS3A; RPS23; RPS14; RPS18; RPS10; RPS12; RPS4X; RPS20; EIF3E; EIF3H; RPS6; RPS13; RPS3; RPS25; RPS24; RPS29; RPS17; RPS2; RPS21; RPS15; RPS28; RPS16; RPS11; RPS9; RPS5; EIF3L
R-HSA-168254	Influenza Infection	13.90	0.00e+00	0.00e+00	72/137	RPL22; RPL11; RPS8; RPL5; RPS7; RPS27A; RPL31; RPL37A; RPL32; RPL15; RPSA; RPL14; RPL29; RPL24; RPL35A; RPL9; RPL34; RPS3A; RPL37; RPS23; RPS14; RPS18; RPS10; RPL10A; RPS12; SLC25A6; RPS4X; RPL36A; RPL39; RPL10; RPS20; RPL7; RPL30; RPL8; RPS6; RPL35; RPL12; RPL7A; RPLP2; RPL27A; RPS13; RPS3; RPS25; RPS24; RPL41; RPL6; RPLP0; RPL21; RPS29; RPL4; RPLP1; RPS17; RPS2; RPL13; RPL26; RPL23A; RPL19; RPL27; RPL38; RPS21; RPS15; RPL36; RPS28; RPL18A; RPS16; RPL18; RPL13A; RPS11; RPS9; RPL28; RPS5; RPL3
R-HSA-9010553	Regulation of expression of SLITs and ROBOs	13.30	0.00e+00	0.00e+00	74/147	RPL22; RPL11; RPS8; RPL5; RPS7; RPS27A; RPL31; RPL37A; RPL32; RPL15; RPSA; RPL14; RPL29; RPL24; RPL35A; RPL9; RPL34; RPS3A; RPL37; RPS23; RPS14; RPS18; RPS10; RPL10A; RPS12; RPS4X; RPL36A; RPL39; RPL10; RPS20; RPL7; RPL30; PABPC1; RPL8; RPS6; RPL35; RPL12; RPL7A; RPLP2; RPL27A; RPS13; RPS3; RPS25; RPS24; RPL41; RPL6; RPLP0; UBC; RPL21; RPS29; RPL4; RPLP1; RPS17; RPS2; RPL13; RPL26; UBB; RPL23A; RPL19; RPL27; RPL38; RPS21; RPS15; RPL36; RPS28; RPL18A; RPS16; RPL18; RPL13A; RPS11; RPS9; RPL28; RPS5; RPL3
R-HSA-6791226	Major pathway of rRNA processing in the nucleolus and cytosol	12.40	0.00e+00	0.00e+00	71/151	RPL22; RPL11; RPS8; RPL5; RPS7; RPS27A; RPL31; RPL37A; RPL32; RPL15; RPSA; RPL14; RPL29; RPL24; RPL35A; RPL9; RPL34; RPS3A; RPL37; RPS23; RPS14; RPS18; RPS10; RPL10A; RPS12; RPS4X; RPL36A; RPL39; RPL10; RPS20; RPL7; RPL30; RPL8; RPS6; RPL35; RPL12; RPL7A; RPLP2; RPL27A; RPS13; RPS3; RPS25; RPS24; RPL41; RPL6; RPLP0; RPL21; RPS29; RPL4; RPLP1; RPS17; RPS2; RPL13; RPL26; RPL23A; RPL19; RPL27; RPL38; RPS21; RPS15; RPL36; RPS28; RPL18A; RPS16; RPL18; RPL13A; RPS11; RPS9; RPL28; RPS5; RPL3
R-HSA-8868773	rRNA processing in the nucleus and cytosol	11.90	0.00e+00	0.00e+00	72/160	RPL22; RPL11; RPS8; RPL5; RPS7; RPS27A; RPL31; RPL37A; RPL32; RPL15; RPSA; RPL14; RPL29; RPL24; RPL35A; RPL9; RPL34; RPS3A; RPL37; RPS23; RPS14; RPS18; RPS10; RPL10A; RPS12; RPS4X; RPL36A; RPL39; RPL10; RPS20; RPL7; RPL30; RPL8; RPS6; RPL35; RPL12; RPL7A; RPLP2; RPL27A; RPS13; RPS3; RPS25; RPS24; RPL41; RPL6; RPLP0; RPL21; RPS29; NOP10; RPL4; RPLP1; RPS17; RPS2; RPL13; RPL26; RPL23A; RPL19; RPL27; RPL38; RPS21; RPS15; RPL36; RPS28; RPL18A; RPS16; RPL18; RPL13A; RPS11; RPS9; RPL28; RPS5; RPL3
R-HSA-376176	Signaling by ROBO receptors	11.90	0.00e+00	0.00e+00	75/167	RPL22; RPL11; RPS8; RPL5; RPS7; RPS27A; RPL31; RPL37A; RPL32; RPL15; RPSA; RPL14; RPL29; RPL24; RPL35A; RPL9; RPL34; RPS3A; RPL37; RPS23; RPS14; RPS18; RPS10; RPL10A; RPS12; RPS4X; RPL36A; RPL39; RPL10; RPS20; RPL7; RPL30; PABPC1; RPL8; RPS6; RPL35; RPL12; RPL7A; RPLP2; RPL27A; RPS13; RPS3; RPS25; RPS24; RPL41; RPL6; RPLP0; UBC; RPL21; RPS29; EVL; RPL4; RPLP1; RPS17; RPS2; RPL13; RPL26; UBB; RPL23A; RPL19; RPL27; RPL38; RPS21; RPS15; RPL36; RPS28; RPL18A; RPS16; RPL18; RPL13A; RPS11; RPS9; RPL28; RPS5; RPL3
R-HSA-72312	rRNA processing	11.50	0.00e+00	0.00e+00	72/166	RPL22; RPL11; RPS8; RPL5; RPS7; RPS27A; RPL31; RPL37A; RPL32; RPL15; RPSA; RPL14; RPL29; RPL24; RPL35A; RPL9; RPL34; RPS3A; RPL37; RPS23; RPS14; RPS18; RPS10; RPL10A; RPS12; RPS4X; RPL36A; RPL39; RPL10; RPS20; RPL7; RPL30; RPL8; RPS6; RPL35; RPL12; RPL7A; RPLP2; RPL27A; RPS13; RPS3; RPS25; RPS24; RPL41; RPL6; RPLP0; RPL21; RPS29; NOP10; RPL4; RPLP1; RPS17; RPS2; RPL13; RPL26; RPL23A; RPL19; RPL27; RPL38; RPS21; RPS15; RPL36; RPS28; RPL18A; RPS16; RPL18; RPL13A; RPS11; RPS9; RPL28; RPS5; RPL3
R-HSA-193639	p75NTR signals via NF-kB	10.60	3.44e-04	8.51e-03	4/10	RPS27A; SQSTM1; UBC; UBB
R-HSA-71291	Metabolism of amino acids and derivatives	9.25	0.00e+00	0.00e+00	71/203	RPL22; RPL11; RPS8; RPL5; RPS7; RPS27A; RPL31; RPL37A; RPL32; RPL15; RPSA; RPL14; RPL29; RPL24; RPL35A; RPL9; RPL34; RPS3A; RPL37; RPS23; RPS14; RPS18; RPS10; RPL10A; RPS12; RPS4X; RPL36A; RPL39; RPL10; RPS20; RPL7; RPL30; RPL8; RPS6; RPL35; RPL12; RPL7A; RPLP2; RPL27A; RPS13; RPS3; RPS25; RPS24; RPL41; RPL6; RPLP0; RPL21; RPS29; RPL4; RPLP1; RPS17; RPS2; RPL13; RPL26; RPL23A; RPL19; RPL27; RPL38; RPS21; RPS15; RPL36; RPS28; RPL18A; RPS16; RPL18; RPL13A; RPS11; RPS9; RPL28; RPS5; RPL3
R-HSA-9013507	NOTCH3 Activation and Transmission of Signal to the Nucleus	8.82	7.63e-04	1.74e-02	4/12	YBX1; RPS27A; UBC; UBB
R-HSA-72766	Translation	8.34	0.00e+00	0.00e+00	81/257	RPL22; RPL11; RPS8; RPL5; RPS7; RPS27A; RPL31; EEF1B2; RPL37A; RPL32; RPL15; RPSA; RPL14; RPL29; RPL24; RPL35A; RPL9; RPL34; RPS3A; RPL37; RPS23; RPS14; RPS18; RPS10; RPL10A; EEF1A1; RPS12; RPS4X; RPL36A; RPL39; RPL10; RPS20; RPL7; RPL30; PABPC1; EIF3E; EIF3H; RPL8; RPS6; RPL35; RPL12; RPL7A; RPLP2; CARS; RPL27A; RPS13; RPS3; RPS25; PPA1; RPS24; RPL41; RPL6; RPLP0; RPL21; RPS29; RPL4; RPLP1; RPS17; RPS2; RPL13; RPL26; RPL23A; RPL19; RPL27; RPL38; RPS21; RPS15; EEF2; RPL36; RPS28; RPL18A; RPS16; RPL18; RPL13A; RPS11; RPS9; RPL28; RPS5; EIF3L; RPL3; MRPS6
R-HSA-422475	Axon guidance	7.99	0.00e+00	0.00e+00	77/255	RPL22; RPL11; RPS8; RPL5; PTPRC; RPS7; RPS27A; RPL31; RPL37A; RPL32; RPL15; RPSA; RPL14; RPL29; RPL24; RPL35A; RPL9; RPL34; RPS3A; RPL37; RPS23; RPS14; RPS18; RPS10; RPL10A; HSP90AB1; RPS12; RPS4X; RPL36A; RPL39; RPL10; RPS20; RPL7; RPL30; PABPC1; RPL8; RPS6; RPL35; RPL12; RPL7A; RPLP2; RPL27A; RPS13; RPS3; RPS25; RPS24; RPL41; RPL6; RPLP0; UBC; RPL21; RPS29; EVL; RPL4; RPLP1; RPS17; RPS2; RPL13; RPL26; UBB; RPL23A; RPL19; RPL27; RPL38; RPS21; RPS15; RPL36; RPS28; RPL18A; RPS16; RPL18; RPL13A; RPS11; RPS9; RPL28; RPS5; RPL3
R-HSA-5663205	Infectious disease	7.13	0.00e+00	0.00e+00	80/297	RPL22; RPL11; LCK; RPS8; RPL5; RPS7; RPS27A; CD8B; RPL31; RPL37A; RPL32; RPL15; RPSA; RPL14; RPL29; RPL24; RPL35A; RPL9; RPL34; RPS3A; RPL37; RPS23; RPS14; NPM1; RPS18; RPS10; RPL10A; HSP90AB1; RPS12; SLC25A6; RPS4X; RPL36A; RPL39; RPL10; RPS20; RPL7; RPL30; RPL8; RPS6; RPL35; RPL12; RPL7A; RPLP2; RPL27A; RPS13; RPS3; RPS25; RPS24; RPL41; RPL6; RPLP0; UBC; RPL21; RPS29; B2M; RPL4; RPLP1; RPS17; RPS2; RPL13; RPL26; UBB; RPL23A; RPL19; RPL27; RPL38; RPS21; RPS15; EEF2; RPL36; RPS28; RPL18A; RPS16; RPL18; RPL13A; RPS11; RPS9; RPL28; RPS5; RPL3
R-HSA-5205685	Pink/Parkin Mediated Mitophagy	7.06	1.93e-03	4.18e-02	4/15	RPS27A; SQSTM1; UBC; UBB
R-HSA-198933	Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell	6.77	3.09e-07	8.11e-06	11/43	CD8B; HLA-A; HLA-E; HLA-C; HLA-B; CD3E; CD3D; CLEC2D; CLEC2B; B2M; HCST
R-HSA-983170	Antigen Presentation: Folding, assembly and peptide loading of class I MHC	6.62	7.03e-04	1.69e-02	5/20	HLA-A; HLA-E; HLA-C; HLA-B; B2M
R-HSA-977225	Amyloid fiber formation	6.35	2.56e-04	6.52e-03	6/25	RPS27A; UBC; ITM2B; B2M; UBB; H3F3B
R-HSA-1266738	Developmental Biology	5.80	0.00e+00	0.00e+00	78/356	RPL22; RPL11; RPS8; RPL5; PTPRC; RPS7; RPS27A; RPL31; RPL37A; RPL32; RPL15; RPSA; RPL14; RPL29; RPL24; RPL35A; RPL9; RPL34; RPS3A; RPL37; RPS23; RPS14; RPS18; RPS10; RPL10A; HSP90AB1; RPS12; RPS4X; RPL36A; RPL39; RPL10; RPS20; RPL7; RPL30; PABPC1; RPL8; RPS6; RPL35; RPL12; RPL7A; RPLP2; RPL27A; RPS13; RPS3; RPS25; RPS24; RPL41; RPL6; RPLP0; UBC; RPL21; RPS29; EVL; RPL4; RPLP1; RPS17; RPS2; RPL13; RPL26; UBB; RPL23A; RPL19; RPL27; RPL38; H3F3B; RPS21; RPS15; RPL36; RPS28; RPL18A; RPS16; RPL18; RPL13A; RPS11; RPS9; RPL28; RPS5; RPL3
R-HSA-202433	Generation of second messenger molecules	5.75	1.39e-03	3.09e-02	5/23	LCK; CD3E; CD3D; EVL; LAT
R-HSA-917937	Iron uptake and transport	5.29	7.33e-04	1.72e-02	6/30	RPS27A; ATP6V0E1; ATP6V1G1; UBC; UBB; FTL

Factor 6 : 43 significant Reactome pathways

GeneSet	description	enrichRatio	pValue	FDR	GeneRatio	geneSymbols
R-HSA-375276	Peptide ligand-binding receptors	11.70	4.32e-07	9.26e-05	7/12	UTS2; F2R; CXCR3; ANXA1; CCL5; CCR7; APP
R-HSA-6783783	Interleukin-10 signaling	10.80	8.97e-07	1.30e-04	7/13	TIMP1; CCL5; CCL3; CCL4; CCL3L3; CCL4L2
R-HSA-202430	Translocation of ZAP-70 to Immunological synapse	10.00	1.72e-06	2.13e-04	7/14	HLA-DRA; HLA-DRB5; HLA-DRB1; HLA-DQA1; HLA-DQB1; HLA-DPA1; HLA-DPB1
R-HSA-202427	Phosphorylation of CD3 and TCR zeta chains	9.46	5.34e-07	9.26e-05	8/17	PTPRC; HLA-DRA; HLA-DRB5; HLA-DRB1; HLA-DQA1; HLA-DQB1; HLA-DPA1; HLA-DPB1
R-HSA-389948	PD-1 signaling	9.38	3.09e-06	2.68e-04	7/15	HLA-DRA; HLA-DRB5; HLA-DRB1; HLA-DQA1; HLA-DQB1; HLA-DPA1; HLA-DPB1
R-HSA-381033	ATF6 (ATF6-alpha) activates chaperones	8.04	9.83e-04	2.13e-02	4/10	HSPA5; HSP90B1; CALR; XBP1
R-HSA-216083	Integrin cell surface interactions	7.18	4.00e-04	9.64e-03	5/14	ITGA4; CD44; ITGB1; ITGAL; PECAM1
R-HSA-198933	Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell	7.01	7.15e-10	3.10e-07	15/43	SLAMF7; SELL; CD8A; CD8B; ITGA4; SH2D1A; CD81; JAML; ITGB1; KLRG1; CLEC2D; CLEC2B; KLRD1; KLRC1; ITGAL
R-HSA-202433	Generation of second messenger molecules	6.99	8.31e-06	5.54e-04	8/23	FYB; HLA-DRA; HLA-DRB5; HLA-DRB1; HLA-DQA1; HLA-DQB1; HLA-DPA1; HLA-DPB1
R-HSA-373076	Class A/1 (Rhodopsin-like receptors)	6.70	1.19e-05	7.39e-04	8/24	UTS2; F2R; CXCR3; ANXA1; GPR183; CCL5; CCR7; APP
R-HSA-381070	IRE1alpha activates chaperones	6.09	2.48e-06	2.39e-04	10/33	PDIA6; SEC61A1; SERP1; SEC61G; DNAJB9; SEC61B; HSPA5; ERN1; MYDGF; XBP1
R-HSA-381426	Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)	5.48	5.35e-04	1.22e-02	6/22	PDIA6; TIMP1; HSP90B1; GZMH; P4HB; APP
R-HSA-381038	XBP1(S) activates chaperone genes	5.19	9.48e-05	3.42e-03	8/31	PDIA6; SEC61A1; SERP1; SEC61G; DNAJB9; SEC61B; MYDGF; XBP1
R-HSA-877300	Interferon gamma signaling	5.02	6.23e-06	4.50e-04	11/44	GBP2; GBP4; GBP5; HLA-DRA; HLA-DRB5; HLA-DRB1; HLA-DQA1; HLA-DQB1; HLA-DPA1; HLA-DPB1; CD44
R-HSA-388841	Costimulation by the CD28 family	5.02	1.67e-05	9.48e-04	10/40	THEM4; ICOS; HLA-DRA; HLA-DRB5; HLA-DRB1; HLA-DQA1; HLA-DQB1; HLA-DPA1; HLA-DPB1; FYN
R-HSA-500792	GPCR ligand binding	5.02	1.21e-04	4.20e-03	8/32	UTS2; F2R; CXCR3; ANXA1; GPR183; CCL5; CCR7; APP
R-HSA-1799339	SRP-dependent cotranslational protein targeting to membrane	4.74	2.04e-11	1.77e-08	25/106	RPL11; SSR2; SEC61A1; SSR3; RPL9; SPCS3; RPS18; SEC61G; RPS4X; SSR4; RPL10; RPS20; TRAM1; RPS6; SEC61B; RPL12; RPL7A; RPL27A; SPCS2; RPL36AL; RPS15A; SEC11C; RPN2; RPS19; RPL18
R-HSA-1474244	Extracellular matrix organization	4.41	1.35e-04	4.49e-03	9/41	ITGA4; TIMP1; CD44; ITGB1; PPIB; ITGAL; PECAM1; P4HB; APP
R-HSA-202733	Cell surface interactions at the vascular wall	4.31	1.64e-04	4.94e-03	9/42	SELL; ITGA4; CD74; FYN; CD44; JAML; ITGB1; ITGAL; PECAM1
R-HSA-381119	Unfolded Protein Response (UPR)	4.16	1.91e-05	9.76e-04	12/58	PDIA6; SEC61A1; SERP1; SEC61G; DNAJB9; SEC61B; HSPA5; HSP90B1; ERN1; MYDGF; CALR; XBP1
R-HSA-6785807	Interleukin-4 and Interleukin-13 signaling	4.14	1.15e-03	2.38e-02	7/34	TIMP1; CEBPD; ANXA1; GATA3; ITGB1; HSP90B1; IL4R
R-HSA-156902	Peptide chain elongation	3.83	2.38e-06	2.39e-04	16/84	RPL11; RPL9; RPS18; EEF1A1; RPS4X; RPL10; RPS20; RPS6; RPL12; RPL7A; RPL27A; RPL36AL; RPS15A; EEF2; RPS19; RPL18
R-HSA-156842	Eukaryotic Translation Elongation	3.70	3.87e-06	3.05e-04	16/87	RPL11; RPL9; RPS18; EEF1A1; RPS4X; RPL10; RPS20; RPS6; RPL12; RPL7A; RPL27A; RPL36AL; RPS15A; EEF2; RPS19; RPL18
R-HSA-2132295	MHC class II antigen presentation	3.51	2.18e-04	5.90e-03	11/63	CD74; CANX; HLA-DRA; HLA-DRB5; HLA-DRB1; HLA-DQA1; HLA-DQB1; HLA-DMB; HLA-DPA1; HLA-DPB1; LAG3
R-HSA-975956	Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)	3.43	2.06e-05	9.93e-04	15/88	RPL11; RPL9; RPS18; RPS4X; RPL10; RPS20; PABPC1; RPS6; RPL12; RPL7A; RPL27A; RPL36AL; RPS15A; RPS19; RPL18
R-HSA-192823	Viral mRNA Translation	3.35	5.10e-05	2.11e-03	14/84	RPL11; RPL9; RPS18; RPS4X; RPL10; RPS20; RPS6; RPL12; RPL7A; RPL27A; RPL36AL; RPS15A; RPS19; RPL18
R-HSA-2408557	Selenocysteine synthesis	3.31	5.84e-05	2.30e-03	14/85	RPL11; RPL9; RPS18; RPS4X; RPL10; RPS20; RPS6; RPL12; RPL7A; RPL27A; RPL36AL; RPS15A; RPS19; RPL18
R-HSA-72764	Eukaryotic Translation Termination	3.23	7.62e-05	2.87e-03	14/87	RPL11; RPL9; RPS18; RPS4X; RPL10; RPS20; RPS6; RPL12; RPL7A; RPL27A; RPL36AL; RPS15A; RPS19; RPL18
R-HSA-72689	Formation of a pool of free 40S subunits	2.96	2.02e-04	5.66e-03	14/95	RPL11; RPL9; RPS18; RPS4X; RPL10; RPS20; RPS6; RPL12; RPL7A; RPL27A; RPL36AL; RPS15A; RPS19; RPL18
R-HSA-156827	L13a-mediated translational silencing of Ceruloplasmin expression	2.87	1.71e-04	4.94e-03	15/105	RPL11; RPL9; RPS18; RPS4X; RPL10; RPS20; PABPC1; RPS6; RPL12; RPL7A; RPL27A; RPL36AL; RPS15A; RPS19; RPL18
R-HSA-927802	Nonsense-Mediated Decay (NMD)	2.87	1.71e-04	4.94e-03	15/105	RPL11; RPL9; RPS18; RPS4X; RPL10; RPS20; PABPC1; RPS6; RPL12; RPL7A; RPL27A; RPL36AL; RPS15A; RPS19; RPL18
R-HSA-975957	Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)	2.87	1.71e-04	4.94e-03	15/105	RPL11; RPL9; RPS18; RPS4X; RPL10; RPS20; PABPC1; RPS6; RPL12; RPL7A; RPL27A; RPL36AL; RPS15A; RPS19; RPL18
R-HSA-2408522	Selenoamino acid metabolism	2.84	3.16e-04	8.29e-03	14/99	RPL11; RPL9; RPS18; RPS4X; RPL10; RPS20; RPS6; RPL12; RPL7A; RPL27A; RPL36AL; RPS15A; RPS19; RPL18
R-HSA-72613	Eukaryotic Translation Initiation	2.69	3.54e-04	8.78e-03	15/112	RPL11; RPL9; RPS18; RPS4X; RPL10; RPS20; PABPC1; RPS6; RPL12; RPL7A; RPL27A; RPL36AL; RPS15A; RPS19; RPL18
R-HSA-72737	Cap-dependent Translation Initiation	2.69	3.54e-04	8.78e-03	15/112	RPL11; RPL9; RPS18; RPS4X; RPL10; RPS20; PABPC1; RPS6; RPL12; RPL7A; RPL27A; RPL36AL; RPS15A; RPS19; RPL18
R-HSA-72706	GTP hydrolysis and joining of the 60S ribosomal subunit	2.65	6.46e-04	1.44e-02	14/106	RPL11; RPL9; RPS18; RPS4X; RPL10; RPS20; RPS6; RPL12; RPL7A; RPL27A; RPL36AL; RPS15A; RPS19; RPL18
R-HSA-168255	Influenza Life Cycle	2.51	5.00e-04	1.17e-02	16/128	RPL11; RPL9; CANX; RPS18; RPS4X; RPL10; RPS20; RPS6; RPL12; RPL7A; RPL27A; RPL36AL; RPS15A; CALR; RPS19; RPL18
R-HSA-1280215	Cytokine Signaling in Immune system	2.49	3.53e-08	1.02e-05	39/315	JUN; GBP2; GBP4; GBP5; CANX; LTB; HLA-DRA; HLA-DRB5; HLA-DRB1; HLA-DQA1; HLA-DQB1; HLA-DPA1; HLA-DPB1; FYN; PSMC2; TIMP1; CEBPD; ANXA1; IFITM2; CD44; IL2RA; GATA3; ITGB1; PDCD4; CD27; HSP90B1; HMGB1; RPS6KA5; IL32; IL4R; CCL5; CCL3; CCL4; CCL3L3; CCL4L2; P4HB; CNN2; APP
R-HSA-449147	Signaling by Interleukins	2.39	2.87e-05	1.24e-03	25/210	JUN; CANX; FYN; PSMC2; TIMP1; CEBPD; ANXA1; IL2RA; GATA3; ITGB1; PDCD4; HSP90B1; HMGB1; RPS6KA5; IL32; IL4R; CCL5; CCL3; CCL4; CCL3L3; CCL4L2; P4HB; CNN2; APP
R-HSA-168273	Influenza Viral RNA Transcription and Replication	2.36	2.04e-03	4.11e-02	14/119	RPL11; RPL9; RPS18; RPS4X; RPL10; RPS20; RPS6; RPL12; RPL7A; RPL27A; RPL36AL; RPS15A; RPS19; RPL18
R-HSA-168254	Influenza Infection	2.35	1.07e-03	2.25e-02	16/137	RPL11; RPL9; CANX; RPS18; RPS4X; RPL10; RPS20; RPS6; RPL12; RPL7A; RPL27A; RPL36AL; RPS15A; CALR; RPS19; RPL18
R-HSA-72766	Translation	2.27	1.75e-05	9.48e-04	29/257	RPL11; SSR2; SEC61A1; SSR3; RPL9; SPCS3; RPS18; EEF1A1; SEC61G; RPS4X; SSR4; RPL10; RPS20; TRAM1; PABPC1; RPS6; SEC61B; RPL12; RPL7A; RPL27A; SPCS2; RPL36AL; RPS15A; MRPL10; SEC11C; RPN2; EEF2; RPS19; RPL18
R-HSA-9010553	Regulation of expression of SLITs and ROBOs	2.19	2.26e-03	4.35e-02	16/147	RPL11; RPL9; RPS18; PSMC2; RPS4X; RPL10; RPS20; PABPC1; RPS6; RPL12; RPL7A; RPL27A; RPL36AL; RPS15A; RPS19; RPL18

Factor 7 : 100 significant Reactome pathways

GeneSet	description	enrichRatio	pValue	FDR	GeneRatio	geneSymbols
R-HSA-140342	Apoptosis induced DNA fragmentation	31.50	7.57e-09	4.38e-07	6/10	HMGB2; HIST1H1C; HIST1H1E; HIST1H1D; HIST1H1B; HMGB1
R-HSA-211227	Activation of DNA fragmentation factor	31.50	7.57e-09	4.38e-07	6/10	HMGB2; HIST1H1C; HIST1H1E; HIST1H1D; HIST1H1B; HMGB1
R-HSA-2299718	Condensation of Prophase Chromosomes	24.30	5.91e-08	2.70e-06	6/13	HIST2H2AC; SMC4; H2AFZ; HIST1H4C; H2AFV; SMC2
R-HSA-983189	Kinesins	24.30	5.91e-08	2.70e-06	6/13	TUBB4B; KIF20B; TUBA1B; TUBA1A; TUBA1C; KIF22
R-HSA-2559584	Formation of Senescence-Associated Heterochromatin Foci (SAHF)	21.90	1.54e-06	4.46e-05	5/12	LMNB1; HIST1H1C; HIST1H1E; HIST1H1D; HIST1H1B
R-HSA-171306	Packaging Of Telomere Ends	21.00	2.32e-05	5.03e-04	4/10	HIST2H2AC; H2AFZ; HIST1H4C; H2AFV
R-HSA-5334118	DNA methylation	21.00	2.32e-05	5.03e-04	4/10	HIST2H2AC; H2AFZ; HIST1H4C; H2AFV
R-HSA-389977	Post-chaperonin tubulin folding pathway	21.00	2.32e-05	5.03e-04	4/10	TUBB4B; TUBA1B; TUBA1A; TUBA1C
R-HSA-5626467	RHO GTPases activate IQGAPs	19.70	2.64e-07	1.09e-05	6/16	CALM2; TUBB4B; TUBA1B; TUBA1A; TUBA1C; CALM3
R-HSA-73728	RNA Polymerase I Promoter Opening	19.10	3.59e-05	7.24e-04	4/11	HIST2H2AC; H2AFZ; HIST1H4C; H2AFV
R-HSA-157858	Gap junction trafficking and regulation	17.50	5.31e-05	9.21e-04	4/12	TUBB4B; TUBA1B; TUBA1A; TUBA1C
R-HSA-190828	Gap junction trafficking	17.50	5.31e-05	9.21e-04	4/12	TUBB4B; TUBA1B; TUBA1A; TUBA1C
R-HSA-427359	SIRT1 negatively regulates rRNA expression	17.50	5.31e-05	9.21e-04	4/12	HIST2H2AC; H2AFZ; HIST1H4C; H2AFV
R-HSA-5625886	Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3	17.50	5.31e-05	9.21e-04	4/12	HIST2H2AC; H2AFZ; HIST1H4C; H2AFV
R-HSA-2559586	DNA Damage/Telomere Stress Induced Senescence	16.90	1.00e-09	8.70e-08	9/28	HIST2H2AC; H2AFZ; LMNB1; HIST1H1C; HIST1H4C; HIST1H1E; HIST1H1D; HIST1H1B; H2AFV
R-HSA-606279	Deposition of new CENPA-containing nucleosomes at the centromere	16.60	8.54e-07	2.96e-05	6/19	ITGB3BP; HIST2H2AC; H2AFZ; HIST1H4C; H2AFV; CENPM
R-HSA-774815	Nucleosome assembly	16.60	8.54e-07	2.96e-05	6/19	ITGB3BP; HIST2H2AC; H2AFZ; HIST1H4C; H2AFV; CENPM
R-HSA-389960	Formation of tubulin folding intermediates by CCT/TriC	16.20	7.56e-05	1.21e-03	4/13	TUBB4B; TUBA1B; TUBA1A; TUBA1C
R-HSA-212300	PRC2 methylates histones and DNA	15.80	1.20e-06	3.86e-05	6/20	HIST2H2AC; H2AFZ; HIST1H4C; H2AFV; EZH2; PHF19
R-HSA-1221632	Meiotic synapsis	14.30	2.25e-06	6.28e-05	6/22	HIST2H2AC; H2AFZ; LMNB1; HIST1H4C; H2AFV; RAD21
R-HSA-75153	Apoptotic execution phase	13.60	6.38e-08	2.77e-06	8/31	HMGB2; LMNB1; HIST1H1C; HIST1H1E; HIST1H1D; HIST1H1B; VIM; HMGB1
R-HSA-499943	Interconversion of nucleotide di- and triphosphates	12.40	2.38e-04	3.32e-03	4/17	DTYMK; RRM1; DUT; TYMS
R-HSA-912446	Meiotic recombination	11.70	3.01e-04	3.90e-03	4/18	HIST2H2AC; H2AFZ; HIST1H4C; H2AFV
R-HSA-5620924	Intraflagellar transport	11.70	3.01e-04	3.90e-03	4/18	TUBB4B; TUBA1B; TUBA1A; TUBA1C
R-HSA-2500257	Resolution of Sister Chromatid Cohesion	11.60	2.77e-11	3.00e-09	13/59	ITGB3BP; CENPF; MAD2L1; RAD21; TUBB4B; CKAP5; BUB3; TUBA1B; TUBA1A; TUBA1C; SKA2; NDC80; CENPM
R-HSA-179409	APC-Cdc20 mediated degradation of Nek2A	11.10	3.76e-04	4.53e-03	4/19	MAD2L1; BUB3; UBB; UBE2C
R-HSA-141405	Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components	10.50	2.55e-03	2.35e-02	3/15	MAD2L1; BUB3; UBE2C
R-HSA-141430	Inactivation of APC/C via direct inhibition of the APC/C complex	10.50	2.55e-03	2.35e-02	3/15	MAD2L1; BUB3; UBE2C
R-HSA-427389	ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression	10.50	4.63e-04	5.43e-03	4/20	HIST2H2AC; H2AFZ; HIST1H4C; H2AFV
R-HSA-389958	Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding	10.50	4.63e-04	5.43e-03	4/20	TUBB4B; TUBA1B; TUBA1A; TUBA1C
R-HSA-5663220	RHO GTPases Activate Formins	9.85	1.29e-09	1.02e-07	12/64	ITGB3BP; CENPF; MAD2L1; TUBB4B; CKAP5; BUB3; TUBA1B; TUBA1A; TUBA1C; SKA2; NDC80; CENPM
R-HSA-8982491	Glycogen metabolism	9.85	3.10e-03	2.83e-02	3/16	CALM2; UBB; CALM3
R-HSA-68877	Mitotic Prometaphase	9.69	1.15e-14	2.50e-12	19/103	ITGB3BP; CENPF; SMC4; MAD2L1; TUBB; RAD21; CEP78; SMC2; CNTRL; TUBB4B; CKAP5; BUB3; TUBA1B; TUBA1A; TUBA1C; MZT1; SKA2; NDC80; CENPM
R-HSA-5250924	B-WICH complex positively regulates rRNA expression	9.38	1.51e-04	2.26e-03	5/28	HIST2H2AC; H2AFZ; DEK; HIST1H4C; H2AFV
R-HSA-141424	Amplification of signal from the kinetochores	9.34	1.41e-06	4.21e-05	8/45	ITGB3BP; CENPF; MAD2L1; CKAP5; BUB3; SKA2; NDC80; CENPM
R-HSA-141444	Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal	9.34	1.41e-06	4.21e-05	8/45	ITGB3BP; CENPF; MAD2L1; CKAP5; BUB3; SKA2; NDC80; CENPM
R-HSA-1500620	Meiosis	9.27	3.38e-05	7.15e-04	6/34	HIST2H2AC; H2AFZ; LMNB1; HIST1H4C; H2AFV; RAD21
R-HSA-5339562	Uptake and actions of bacterial toxins	9.27	3.71e-03	3.31e-02	3/17	CALM2; HSP90AB1; CALM3
R-HSA-2559582	Senescence-Associated Secretory Phenotype (SASP)	9.20	7.55e-06	1.93e-04	7/40	HIST2H2AC; H2AFZ; HIST1H4C; H2AFV; UBB; UBE2C; CDKN2D
R-HSA-1912408	Pre-NOTCH Transcription and Translation	9.14	8.11e-04	9.13e-03	4/23	HIST2H2AC; H2AFZ; HIST1H4C; H2AFV
R-HSA-437239	Recycling pathway of L1	9.14	8.11e-04	9.13e-03	4/23	TUBB4B; TUBA1B; TUBA1A; TUBA1C
R-HSA-380320	Recruitment of NuMA to mitotic centrosomes	8.92	4.41e-07	1.74e-05	9/53	TUBB; CEP78; CNTRL; TUBB4B; CKAP5; TUBA1B; TUBA1A; TUBA1C; MZT1
R-HSA-73886	Chromosome Maintenance	8.76	4.75e-05	8.95e-04	6/36	ITGB3BP; HIST2H2AC; H2AFZ; HIST1H4C; H2AFV; CENPM
R-HSA-157579	Telomere Maintenance	8.76	9.59e-04	1.03e-02	4/24	HIST2H2AC; H2AFZ; HIST1H4C; H2AFV
R-HSA-8936459	RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function	8.76	9.59e-04	1.03e-02	4/24	HIST2H2AC; H2AFZ; HIST1H4C; H2AFV
R-HSA-1474165	Reproduction	8.52	5.59e-05	9.50e-04	6/37	HIST2H2AC; H2AFZ; LMNB1; HIST1H4C; H2AFV; RAD21
R-HSA-977225	Amyloid fiber formation	8.41	1.13e-03	1.19e-02	4/25	HIST2H2AC; H2AFZ; HIST1H4C; UBB
R-HSA-8854518	AURKA Activation by TPX2	8.36	1.46e-05	3.52e-04	7/44	TUBB; CEP78; CNTRL; TUBB4B; CKAP5; TUBA1A; TPX2
R-HSA-373760	L1CAM interactions	8.30	6.53e-05	1.07e-03	6/38	SPTBN1; SDCBP; TUBB4B; TUBA1B; TUBA1A; TUBA1C
R-HSA-2672351	Stimuli-sensing channels	8.30	5.14e-03	4.50e-02	3/19	CALM2; UBB; CALM3
R-HSA-389957	Prefoldin mediated transfer of substrate to CCT/TriC	8.30	5.14e-03	4.50e-02	3/19	TUBB4B; TUBA1A; TUBA1C
R-HSA-69618	Mitotic Spindle Checkpoint	8.15	9.83e-07	3.28e-05	9/58	ITGB3BP; CENPF; MAD2L1; CKAP5; BUB3; SKA2; NDC80; UBE2C; CENPM
R-HSA-201722	Formation of the beta-catenin:TCF transactivating complex	8.08	1.31e-03	1.37e-02	4/26	HIST2H2AC; H2AFZ; HIST1H4C; H2AFV
R-HSA-2559580	Oxidative Stress Induced Senescence	8.00	1.98e-05	4.64e-04	7/46	HIST2H2AC; H2AFZ; HIST1H4C; H2AFV; EZH2; UBB; CDKN2D
R-HSA-3371497	HSP90 chaperone cycle for steroid hormone receptors (SHR)	7.96	3.39e-04	4.20e-03	5/33	HSP90AB1; TUBB4B; TUBA1B; TUBA1A; TUBA1C
R-HSA-2559583	Cellular Senescence	7.67	6.19e-09	4.13e-07	13/89	HIST2H2AC; H2AFZ; LMNB1; HIST1H1C; HIST1H4C; HIST1H1E; HIST1H1D; HIST1H1B; H2AFV; EZH2; UBB; UBE2C; CDKN2D
R-HSA-6811434	COPI-dependent Golgi-to-ER retrograde traffic	7.51	1.17e-04	1.84e-03	6/42	TUBB4B; KIF20B; TUBA1B; TUBA1A; TUBA1C; KIF22
R-HSA-3214858	RMTs methylate histone arginines	7.51	1.75e-03	1.72e-02	4/28	HIST2H2AC; H2AFZ; HIST1H4C; H2AFV
R-HSA-73777	RNA Polymerase I Chain Elongation	7.51	1.75e-03	1.72e-02	4/28	HIST2H2AC; H2AFZ; HIST1H4C; H2AFV
R-HSA-983231	Factors involved in megakaryocyte development and platelet production	7.36	3.48e-05	7.18e-04	7/50	TUBB4B; KIF20B; TUBA1B; TUBA1A; TUBA1C; CBX5; KIF22
R-HSA-2555396	Mitotic Metaphase and Anaphase	7.33	9.81e-12	1.42e-09	18/129	ITGB3BP; CENPF; MAD2L1; LMNB1; PTTG1; RAD21; TUBB4B; CKAP5; BUB3; TUBA1B; TUBA1A; TUBA1C; TMPO; UBB; SKA2; NDC80; UBE2C; CENPM
R-HSA-68882	Mitotic Anaphase	7.33	9.81e-12	1.42e-09	18/129	ITGB3BP; CENPF; MAD2L1; LMNB1; PTTG1; RAD21; TUBB4B; CKAP5; BUB3; TUBA1B; TUBA1A; TUBA1C; TMPO; UBB; SKA2; NDC80; UBE2C; CENPM
R-HSA-380259	Loss of Nlp from mitotic centrosomes	7.33	1.34e-04	2.04e-03	6/43	TUBB; CEP78; CNTRL; TUBB4B; CKAP5; TUBA1A
R-HSA-380284	Loss of proteins required for interphase microtubule organization from the centrosome	7.33	1.34e-04	2.04e-03	6/43	TUBB; CEP78; CNTRL; TUBB4B; CKAP5; TUBA1A
R-HSA-1912422	Pre-NOTCH Expression and Processing	7.25	2.00e-03	1.90e-02	4/29	HIST2H2AC; H2AFZ; HIST1H4C; H2AFV
R-HSA-5693606	DNA Double Strand Break Response	7.25	2.00e-03	1.90e-02	4/29	WHSC1; HIST1H4C; UBB; KPNA2
R-HSA-5625740	RHO GTPases activate PKNs	7.25	2.00e-03	1.90e-02	4/29	HIST2H2AC; H2AFZ; HIST1H4C; H2AFV
R-HSA-380270	Recruitment of mitotic centrosome proteins and complexes	7.07	4.52e-05	8.71e-04	7/52	TUBB; CEP78; CNTRL; TUBB4B; CKAP5; TUBA1A; MZT1
R-HSA-380287	Centrosome maturation	7.07	4.52e-05	8.71e-04	7/52	TUBB; CEP78; CNTRL; TUBB4B; CKAP5; TUBA1A; MZT1
R-HSA-2467813	Separation of Sister Chromatids	7.01	3.42e-10	3.29e-08	16/120	ITGB3BP; CENPF; MAD2L1; PTTG1; RAD21; TUBB4B; CKAP5; BUB3; TUBA1B; TUBA1A; TUBA1C; UBB; SKA2; NDC80; UBE2C; CENPM
R-HSA-68875	Mitotic Prophase	7.01	1.33e-05	3.30e-04	8/60	HIST2H2AC; SMC4; H2AFZ; LMNB1; HIST1H4C; H2AFV; SMC2; TMPO
R-HSA-6811436	COPI-independent Golgi-to-ER retrograde traffic	7.01	2.27e-03	2.14e-02	4/30	TUBB4B; TUBA1B; TUBA1A; TUBA1C
R-HSA-195258	RHO GTPase Effectors	7.01	2.17e-11	2.68e-09	18/135	ITGB3BP; HIST2H2AC; CENPF; CALM2; H2AFZ; MAD2L1; HIST1H4C; H2AFV; TUBB4B; CKAP5; BUB3; TUBA1B; TUBA1A; TUBA1C; SKA2; NDC80; CALM3; CENPM
R-HSA-1445148	Translocation of SLC2A4 (GLUT4) to the plasma membrane	6.85	1.97e-04	2.84e-03	6/46	CALM2; TUBB4B; TUBA1B; TUBA1A; TUBA1C; CALM3
R-HSA-69278	Cell Cycle, Mitotic	6.83	0.00e+00	0.00e+00	36/277	ITGB3BP; HIST2H2AC; CKS1B; CENPF; SMC4; H2AFZ; MAD2L1; LMNB1; PTTG1; HIST1H4C; TUBB; HSP90AB1; H2AFV; DBF4; RAD21; CEP78; SMC2; CNTRL; TUBB4B; CKAP5; BUB3; TUBA1B; TUBA1A; TUBA1C; TMPO; MZT1; UBB; TOP2A; SKA2; TYMS; NDC80; CDC25B; TPX2; UBE2C; CDKN2D; CENPM
R-HSA-2565942	Regulation of PLK1 Activity at G2/M Transition	6.81	5.81e-05	9.68e-04	7/54	TUBB; CEP78; CNTRL; TUBB4B; CKAP5; TUBA1A; UBB
R-HSA-68886	M Phase	6.78	0.00e+00	0.00e+00	28/217	ITGB3BP; HIST2H2AC; CENPF; SMC4; H2AFZ; MAD2L1; LMNB1; PTTG1; HIST1H4C; TUBB; H2AFV; RAD21; CEP78; SMC2; CNTRL; TUBB4B; CKAP5; BUB3; TUBA1B; TUBA1A; TUBA1C; TMPO; MZT1; UBB; SKA2; NDC80; UBE2C; CENPM
R-HSA-5250913	Positive epigenetic regulation of rRNA expression	6.57	8.48e-04	9.43e-03	5/40	HIST2H2AC; H2AFZ; DEK; HIST1H4C; H2AFV
R-HSA-5620912	Anchoring of the basal body to the plasma membrane	6.18	3.51e-04	4.28e-03	6/51	TUBB; CEP78; CNTRL; TUBB4B; CKAP5; TUBA1A
R-HSA-69275	G2/M Transition	6.03	3.72e-08	2.01e-06	14/122	CENPF; TUBB; HSP90AB1; CEP78; CNTRL; TUBB4B; CKAP5; TUBA1B; TUBA1A; TUBA1C; MZT1; UBB; CDC25B; TPX2
R-HSA-453274	Mitotic G2-G2/M phases	5.98	4.13e-08	2.11e-06	14/123	CENPF; TUBB; HSP90AB1; CEP78; CNTRL; TUBB4B; CKAP5; TUBA1B; TUBA1A; TUBA1C; MZT1; UBB; CDC25B; TPX2
R-HSA-1640170	Cell Cycle	5.89	0.00e+00	0.00e+00	37/330	ITGB3BP; HIST2H2AC; CKS1B; CENPF; SMC4; WHSC1; H2AFZ; MAD2L1; LMNB1; PTTG1; HIST1H4C; TUBB; HSP90AB1; H2AFV; DBF4; RAD21; CEP78; SMC2; CNTRL; TUBB4B; CKAP5; BUB3; TUBA1B; TUBA1A; TUBA1C; TMPO; MZT1; UBB; TOP2A; SKA2; TYMS; NDC80; CDC25B; TPX2; UBE2C; CDKN2D; CENPM
R-HSA-5617472	Activation of anterior HOX genes in hindbrain development during early embryogenesis	5.71	1.62e-03	1.63e-02	5/46	HIST2H2AC; H2AFZ; HIST1H4C; H2AFV; EZH2
R-HSA-5619507	Activation of HOX genes during differentiation	5.71	1.62e-03	1.63e-02	5/46	HIST2H2AC; H2AFZ; HIST1H4C; H2AFV; EZH2
R-HSA-8852276	The role of GTSE1 in G2/M progression after G2 checkpoint	5.63	5.87e-04	6.78e-03	6/56	HSP90AB1; TUBB4B; TUBA1B; TUBA1A; TUBA1C; UBB
R-HSA-9018519	Estrogen-dependent gene expression	5.57	2.13e-04	3.03e-03	7/66	HIST2H2AC; H2AFZ; HIST1H4C; HSP90AB1; H2AFV; RAD21; KPNA2
R-HSA-212165	Epigenetic regulation of gene expression	5.41	2.57e-04	3.54e-03	7/68	HIST2H2AC; H2AFZ; DEK; HIST1H4C; H2AFV; EZH2; PHF19
R-HSA-194315	Signaling by Rho GTPases	5.37	1.93e-09	1.39e-07	18/176	ITGB3BP; HIST2H2AC; CENPF; CALM2; H2AFZ; MAD2L1; HIST1H4C; H2AFV; TUBB4B; CKAP5; BUB3; TUBA1B; TUBA1A; TUBA1C; SKA2; NDC80; CALM3; CENPM
R-HSA-8939211	ESR-mediated signaling	5.25	3.09e-04	3.91e-03	7/70	HIST2H2AC; H2AFZ; HIST1H4C; HSP90AB1; H2AFV; RAD21; KPNA2
R-HSA-5617833	Cilium Assembly	5.00	1.58e-04	2.32e-03	8/84	TUBB; CEP78; CNTRL; TUBB4B; CKAP5; TUBA1B; TUBA1A; TUBA1C
R-HSA-15869	Metabolism of nucleotides	4.87	3.32e-03	3.00e-02	5/54	DTYMK; NUDT1; RRM1; DUT; TYMS
R-HSA-8856688	Golgi-to-ER retrograde transport	4.71	1.53e-03	1.58e-02	6/67	TUBB4B; KIF20B; TUBA1B; TUBA1A; TUBA1C; KIF22
R-HSA-69620	Cell Cycle Checkpoints	4.49	3.79e-06	1.03e-04	13/152	ITGB3BP; CENPF; WHSC1; MAD2L1; HIST1H4C; DBF4; CKAP5; BUB3; UBB; SKA2; NDC80; UBE2C; CENPM
R-HSA-9006931	Signaling by Nuclear Receptors	4.43	8.78e-04	9.64e-03	7/83	HIST2H2AC; H2AFZ; HIST1H4C; HSP90AB1; H2AFV; RAD21; KPNA2
R-HSA-6807878	COPI-mediated anterograde transport	4.31	5.63e-03	4.88e-02	5/61	SPTBN1; TUBB4B; TUBA1B; TUBA1A; TUBA1C
R-HSA-109581	Apoptosis	4.08	2.92e-04	3.89e-03	9/116	HMGB2; LMNB1; HIST1H1C; HIST1H1E; HIST1H1D; HIST1H1B; VIM; HMGB1; UBB
R-HSA-5357801	Programmed Cell Death	4.04	3.12e-04	3.91e-03	9/117	HMGB2; LMNB1; HIST1H1C; HIST1H1E; HIST1H1D; HIST1H1B; VIM; HMGB1; UBB
R-HSA-2262752	Cellular responses to stress	3.77	5.23e-07	1.97e-05	18/251	HIST2H2AC; H2AFZ; LMNB1; HIST1H1C; HIST1H4C; HIST1H1E; HIST1H1D; HIST1H1B; HSP90AB1; H2AFV; EZH2; TUBB4B; TUBA1B; TUBA1A; TUBA1C; UBB; UBE2C; CDKN2D
R-HSA-1852241	Organelle biogenesis and maintenance	3.70	2.92e-04	3.89e-03	10/142	CALM2; TUBB; CEP78; CNTRL; TUBB4B; CKAP5; TUBA1B; TUBA1A; TUBA1C; CALM3
R-HSA-8953897	Cellular responses to external stimuli	3.20	5.88e-06	1.55e-04	18/296	HIST2H2AC; H2AFZ; LMNB1; HIST1H1C; HIST1H4C; HIST1H1E; HIST1H1D; HIST1H1B; HSP90AB1; H2AFV; EZH2; TUBB4B; TUBA1B; TUBA1A; TUBA1C; UBB; UBE2C; CDKN2D

Factor 8 : 45 significant Reactome pathways

GeneSet	description	enrichRatio	pValue	FDR	GeneRatio	geneSymbols
R-HSA-6783783	Interleukin-10 signaling	16.80	6.15e-06	1.57e-04	5/13	CCL5; CCL4; CCL3L3; CCL4L2
R-HSA-156902	Peptide chain elongation	12.50	0.00e+00	0.00e+00	24/84	RPL5; RPS27; RPL37A; RPSA; RPL34; RPS18; RPS4X; RPL10; RPL30; RPL8; RPL7A; RPS3; RPL6; RPLP0; RPL21; RPLP1; RPS2; RPS15A; RPS15; RPS19; RPL13A; RPS9; RPL28; RPS5
R-HSA-192823	Viral mRNA Translation	12.50	0.00e+00	0.00e+00	24/84	RPL5; RPS27; RPL37A; RPSA; RPL34; RPS18; RPS4X; RPL10; RPL30; RPL8; RPL7A; RPS3; RPL6; RPLP0; RPL21; RPLP1; RPS2; RPS15A; RPS15; RPS19; RPL13A; RPS9; RPL28; RPS5
R-HSA-2408557	Selenocysteine synthesis	12.40	0.00e+00	0.00e+00	24/85	RPL5; RPS27; RPL37A; RPSA; RPL34; RPS18; RPS4X; RPL10; RPL30; RPL8; RPL7A; RPS3; RPL6; RPLP0; RPL21; RPLP1; RPS2; RPS15A; RPS15; RPS19; RPL13A; RPS9; RPL28; RPS5
R-HSA-156842	Eukaryotic Translation Elongation	12.10	0.00e+00	0.00e+00	24/87	RPL5; RPS27; RPL37A; RPSA; RPL34; RPS18; RPS4X; RPL10; RPL30; RPL8; RPL7A; RPS3; RPL6; RPLP0; RPL21; RPLP1; RPS2; RPS15A; RPS15; RPS19; RPL13A; RPS9; RPL28; RPS5
R-HSA-72764	Eukaryotic Translation Termination	12.10	0.00e+00	0.00e+00	24/87	RPL5; RPS27; RPL37A; RPSA; RPL34; RPS18; RPS4X; RPL10; RPL30; RPL8; RPL7A; RPS3; RPL6; RPLP0; RPL21; RPLP1; RPS2; RPS15A; RPS15; RPS19; RPL13A; RPS9; RPL28; RPS5
R-HSA-975956	Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)	11.90	0.00e+00	0.00e+00	24/88	RPL5; RPS27; RPL37A; RPSA; RPL34; RPS18; RPS4X; RPL10; RPL30; RPL8; RPL7A; RPS3; RPL6; RPLP0; RPL21; RPLP1; RPS2; RPS15A; RPS15; RPS19; RPL13A; RPS9; RPL28; RPS5
R-HSA-72689	Formation of a pool of free 40S subunits	11.10	0.00e+00	0.00e+00	24/95	RPL5; RPS27; RPL37A; RPSA; RPL34; RPS18; RPS4X; RPL10; RPL30; RPL8; RPL7A; RPS3; RPL6; RPLP0; RPL21; RPLP1; RPS2; RPS15A; RPS15; RPS19; RPL13A; RPS9; RPL28; RPS5
R-HSA-983170	Antigen Presentation: Folding, assembly and peptide loading of class I MHC	10.90	6.53e-05	1.62e-03	5/20	HLA-A; HLA-C; HLA-B; PDIA3; B2M
R-HSA-2408522	Selenoamino acid metabolism	10.60	0.00e+00	0.00e+00	24/99	RPL5; RPS27; RPL37A; RPSA; RPL34; RPS18; RPS4X; RPL10; RPL30; RPL8; RPL7A; RPS3; RPL6; RPLP0; RPL21; RPLP1; RPS2; RPS15A; RPS15; RPS19; RPL13A; RPS9; RPL28; RPS5
R-HSA-156827	L13a-mediated translational silencing of Ceruloplasmin expression	10.40	0.00e+00	0.00e+00	25/105	RPL5; RPS27; RPL37A; RPSA; RPL34; RPS18; RPS4X; RPL10; RPL30; RPL8; RPL7A; RPS3; RPL6; RPLP0; RPL21; RPLP1; RPS2; RPS15A; EIF4A1; RPS15; RPS19; RPL13A; RPS9; RPL28; RPS5
R-HSA-72706	GTP hydrolysis and joining of the 60S ribosomal subunit	10.30	0.00e+00	0.00e+00	25/106	RPL5; RPS27; RPL37A; RPSA; RPL34; RPS18; RPS4X; RPL10; RPL30; RPL8; RPL7A; RPS3; RPL6; RPLP0; RPL21; RPLP1; RPS2; RPS15A; EIF4A1; RPS15; RPS19; RPL13A; RPS9; RPL28; RPS5
R-HSA-72695	Formation of the ternary complex, and subsequently, the 43S complex	10.00	5.16e-09	1.40e-07	11/48	RPS27; RPSA; RPS18; RPS4X; RPS3; RPS2; RPS15A; RPS15; RPS19; RPS9; RPS5
R-HSA-927802	Nonsense-Mediated Decay (NMD)	10.00	0.00e+00	0.00e+00	24/105	RPL5; RPS27; RPL37A; RPSA; RPL34; RPS18; RPS4X; RPL10; RPL30; RPL8; RPL7A; RPS3; RPL6; RPLP0; RPL21; RPLP1; RPS2; RPS15A; RPS15; RPS19; RPL13A; RPS9; RPL28; RPS5
R-HSA-975957	Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)	10.00	0.00e+00	0.00e+00	24/105	RPL5; RPS27; RPL37A; RPSA; RPL34; RPS18; RPS4X; RPL10; RPL30; RPL8; RPL7A; RPS3; RPL6; RPLP0; RPL21; RPLP1; RPS2; RPS15A; RPS15; RPS19; RPL13A; RPS9; RPL28; RPS5
R-HSA-1799339	SRP-dependent cotranslational protein targeting to membrane	9.91	0.00e+00	0.00e+00	24/106	RPL5; RPS27; RPL37A; RPSA; RPL34; RPS18; RPS4X; RPL10; RPL30; RPL8; RPL7A; RPS3; RPL6; RPLP0; RPL21; RPLP1; RPS2; RPS15A; RPS15; RPS19; RPL13A; RPS9; RPL28; RPS5
R-HSA-72613	Eukaryotic Translation Initiation	9.77	0.00e+00	0.00e+00	25/112	RPL5; RPS27; RPL37A; RPSA; RPL34; RPS18; RPS4X; RPL10; RPL30; RPL8; RPL7A; RPS3; RPL6; RPLP0; RPL21; RPLP1; RPS2; RPS15A; EIF4A1; RPS15; RPS19; RPL13A; RPS9; RPL28; RPS5
R-HSA-72737	Cap-dependent Translation Initiation	9.77	0.00e+00	0.00e+00	25/112	RPL5; RPS27; RPL37A; RPSA; RPL34; RPS18; RPS4X; RPL10; RPL30; RPL8; RPL7A; RPS3; RPL6; RPLP0; RPL21; RPLP1; RPS2; RPS15A; EIF4A1; RPS15; RPS19; RPL13A; RPS9; RPL28; RPS5
R-HSA-72649	Translation initiation complex formation	9.55	1.79e-09	5.18e-08	12/55	RPS27; RPSA; RPS18; RPS4X; RPS3; RPS2; RPS15A; EIF4A1; RPS15; RPS19; RPS9; RPS5
R-HSA-72702	Ribosomal scanning and start codon recognition	9.55	1.79e-09	5.18e-08	12/55	RPS27; RPSA; RPS18; RPS4X; RPS3; RPS2; RPS15A; EIF4A1; RPS15; RPS19; RPS9; RPS5
R-HSA-72662	Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S	9.38	2.24e-09	6.26e-08	12/56	RPS27; RPSA; RPS18; RPS4X; RPS3; RPS2; RPS15A; EIF4A1; RPS15; RPS19; RPS9; RPS5
R-HSA-168273	Influenza Viral RNA Transcription and Replication	9.20	0.00e+00	0.00e+00	25/119	RPL5; RPS27; RPL37A; RPSA; RPL34; RPS18; RPS4X; RPL10; RPL30; RPL8; RPL7A; RPS3; RPL6; RPLP0; RPL21; HSP90AA1; RPLP1; RPS2; RPS15A; RPS15; RPS19; RPL13A; RPS9; RPL28; RPS5
R-HSA-168255	Influenza Life Cycle	8.55	0.00e+00	0.00e+00	25/128	RPL5; RPS27; RPL37A; RPSA; RPL34; RPS18; RPS4X; RPL10; RPL30; RPL8; RPL7A; RPS3; RPL6; RPLP0; RPL21; HSP90AA1; RPLP1; RPS2; RPS15A; RPS15; RPS19; RPL13A; RPS9; RPL28; RPS5
R-HSA-168254	Influenza Infection	7.99	0.00e+00	0.00e+00	25/137	RPL5; RPS27; RPL37A; RPSA; RPL34; RPS18; RPS4X; RPL10; RPL30; RPL8; RPL7A; RPS3; RPL6; RPLP0; RPL21; HSP90AA1; RPLP1; RPS2; RPS15A; RPS15; RPS19; RPL13A; RPS9; RPL28; RPS5
R-HSA-9010553	Regulation of expression of SLITs and ROBOs	7.74	0.00e+00	0.00e+00	26/147	RPL5; RPS27; RPL37A; RPSA; RPL34; PSMB8; RPS18; RPS4X; RPL10; RPL30; RPL8; RPL7A; RPS3; RPL6; RPLP0; UBC; RPL21; RPLP1; RPS2; RPS15A; RPS15; RPS19; RPL13A; RPS9; RPL28; RPS5
R-HSA-6791226	Major pathway of rRNA processing in the nucleolus and cytosol	7.54	0.00e+00	0.00e+00	26/151	RPL5; RPS27; RPL37A; NCL; RPSA; RPL34; RPS18; RPS4X; RPL10; RPL30; RPL8; RPL7A; RPS3; DDX21; RPL6; RPLP0; RPL21; RPLP1; RPS2; RPS15A; RPS15; RPS19; RPL13A; RPS9; RPL28; RPS5
R-HSA-373076	Class A/1 (Rhodopsin-like receptors)	7.30	1.90e-03	3.81e-02	4/24	CXCR6; LPAR6; CCL5; S1PR4
R-HSA-8868773	rRNA processing in the nucleus and cytosol	7.12	2.22e-16	8.37e-15	26/160	RPL5; RPS27; RPL37A; NCL; RPSA; RPL34; RPS18; RPS4X; RPL10; RPL30; RPL8; RPL7A; RPS3; DDX21; RPL6; RPLP0; RPL21; RPLP1; RPS2; RPS15A; RPS15; RPS19; RPL13A; RPS9; RPL28; RPS5
R-HSA-376176	Signaling by ROBO receptors	7.08	0.00e+00	0.00e+00	27/167	RPL5; RPS27; RPL37A; SRGAP3; RPSA; RPL34; PSMB8; RPS18; RPS4X; RPL10; RPL30; RPL8; RPL7A; RPS3; RPL6; RPLP0; UBC; RPL21; RPLP1; RPS2; RPS15A; RPS15; RPS19; RPL13A; RPS9; RPL28; RPS5
R-HSA-72312	rRNA processing	6.86	5.55e-16	2.01e-14	26/166	RPL5; RPS27; RPL37A; NCL; RPSA; RPL34; RPS18; RPS4X; RPL10; RPL30; RPL8; RPL7A; RPS3; DDX21; RPL6; RPLP0; RPL21; RPLP1; RPS2; RPS15A; RPS15; RPS19; RPL13A; RPS9; RPL28; RPS5
R-HSA-909733	Interferon alpha/beta signaling	6.84	6.83e-04	1.56e-02	5/32	HLA-A; HLA-C; HLA-B; PSMB8; IFNAR2
R-HSA-198933	Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell	6.11	3.67e-04	8.85e-03	6/43	SELL; HLA-A; HLA-C; HLA-B; KLRB1; B2M
R-HSA-71291	Metabolism of amino acids and derivatives	5.61	8.59e-14	2.98e-12	26/203	RPL5; RPS27; RPL37A; RPSA; RPL34; PSMB8; RPS18; RPS4X; RPL10; RPL30; RPL8; RPL7A; SLC3A2; RPS3; RPL6; RPLP0; RPL21; RPLP1; RPS2; RPS15A; RPS15; RPS19; RPL13A; RPS9; RPL28; RPS5
R-HSA-422475	Axon guidance	5.49	0.00e+00	0.00e+00	32/255	RPL5; RHOC; RPS27; RPL37A; SRGAP3; RPSA; RPL34; PSMB8; RPS18; HSP90AB1; RPS4X; RPL10; FGFR1; RPL30; RPL8; RPL7A; RPS3; RPL6; RPLP0; UBC; RPL21; HSP90AA1; RPLP1; RPS2; RPS15A; ACTG1; RPS15; RPS19; RPL13A; RPS9; RPL28; RPS5
R-HSA-418594	G alpha (i) signalling events	4.57	7.24e-04	1.61e-02	7/67	CXCR6; GPSM3; CCL5; CCL4; CCL4L2; S1PR4
R-HSA-72766	Translation	4.43	2.37e-11	7.35e-10	26/257	RPL5; RPS27; RPL37A; RPSA; RPL34; RPS18; RPS4X; RPL10; RPL30; RPL8; RPL7A; CARS; RPS3; RPL6; RPLP0; RPL21; RPLP1; RPS2; RPS15A; EIF4A1; RPS15; RPS19; RPL13A; RPS9; RPL28; RPS5
R-HSA-5663205	Infectious disease	4.42	4.07e-13	1.36e-11	30/297	RPL5; RPS27; RPL37A; RPSA; RPL34; NPM1; PSMB8; RPS18; HSP90AB1; RPS4X; RPL10; RPL30; RPL8; RPL7A; RPS3; RPL6; RPLP0; UBC; RPL21; HSP90AA1; B2M; RPLP1; RPS2; RPS15A; RPS15; RPS19; RPL13A; RPS9; RPL28; RPS5
R-HSA-1236974	ER-Phagosome pathway	4.38	9.44e-04	2.05e-02	7/70	HLA-A; HLA-C; HLA-B; PSMB8; UBC; PDIA3; B2M
R-HSA-1236975	Antigen processing-Cross presentation	4.09	1.43e-03	3.01e-02	7/75	HLA-A; HLA-C; HLA-B; PSMB8; UBC; PDIA3; B2M
R-HSA-1266738	Developmental Biology	3.94	1.35e-12	4.34e-11	32/356	RPL5; RHOC; RPS27; RPL37A; SRGAP3; RPSA; RPL34; PSMB8; RPS18; HSP90AB1; RPS4X; RPL10; FGFR1; RPL30; RPL8; RPL7A; RPS3; RPL6; RPLP0; UBC; RPL21; HSP90AA1; RPLP1; RPS2; RPS15A; ACTG1; RPS15; RPS19; RPL13A; RPS9; RPL28; RPS5
R-HSA-913531	Interferon Signaling	3.68	6.35e-04	1.49e-02	9/107	HLA-A; HLA-C; HLA-B; PSMB8; FLNA; UBC; B2M; EIF4A1; IFNAR2
R-HSA-388396	GPCR downstream signalling	3.20	1.73e-03	3.57e-02	9/123	RHOC; CXCR6; GPSM3; LPAR6; CCL5; CCL4; CCL4L2; S1PR4
R-HSA-372790	Signaling by GPCR	3.15	1.94e-03	3.81e-02	9/125	RHOC; CXCR6; GPSM3; LPAR6; CCL5; CCL4; CCL4L2; S1PR4
R-HSA-1280215	Cytokine Signaling in Immune system	2.92	4.38e-06	1.15e-04	21/315	HLA-A; HLA-C; HLA-B; LTB; PSMB8; FLNA; MYC; PDCD4; RPLP0; UBC; HSP90AA1; B2M; EIF4A1; CCL5; CCL4; CCL3L3; CCL4L2; CNN2; CD70; IFNAR2
R-HSA-449147	Signaling by Interleukins	2.50	2.57e-03	4.94e-02	12/210	PSMB8; MYC; PDCD4; RPLP0; UBC; HSP90AA1; CCL5; CCL4; CCL3L3; CCL4L2; CNN2

Factor 9 : 42 significant Reactome pathways

GeneSet	description	enrichRatio	pValue	FDR	GeneRatio	geneSymbols
R-HSA-983170	Antigen Presentation: Folding, assembly and peptide loading of class I MHC	17.70	6.13e-06	2.42e-04	5/20	HLA-A; HLA-E; HLA-C; HLA-B; B2M
R-HSA-375276	Peptide ligand-binding receptors	17.70	5.36e-04	1.26e-02	3/12	CXCR4; CCL5; CCR7
R-HSA-198933	Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell	16.40	1.74e-10	1.51e-07	10/43	SELL; CD96; HLA-A; HLA-E; HLA-C; HLA-B; JAML; CD3D; CLEC2D; B2M
R-HSA-977225	Amyloid fiber formation	14.10	1.99e-05	6.91e-04	5/25	H3F3A; HIST1H4C; UBC; ITM2B; B2M
R-HSA-3928662	EPHB-mediated forward signaling	12.50	1.58e-03	3.33e-02	3/17	ARPC5; ACTB; ACTG1
R-HSA-877300	Interferon gamma signaling	9.65	2.78e-05	9.29e-04	6/44	GBP4; HLA-A; HLA-E; HLA-C; HLA-B; B2M
R-HSA-72695	Formation of the ternary complex, and subsequently, the 43S complex	8.84	4.64e-05	1.44e-03	6/48	RPS27; RPS18; RPS4X; RPS24; RPS28; RPS19
R-HSA-909733	Interferon alpha/beta signaling	8.84	9.54e-04	2.07e-02	4/32	HLA-A; HLA-E; HLA-C; HLA-B
R-HSA-156902	Peptide chain elongation	8.42	1.63e-07	2.45e-05	10/84	RPS27; RPS18; RPS4X; RPL10; RPS24; RPL41; RPL13; RPL23; RPS28; RPS19
R-HSA-192823	Viral mRNA Translation	8.42	1.63e-07	2.45e-05	10/84	RPS27; RPS18; RPS4X; RPL10; RPS24; RPL41; RPL13; RPL23; RPS28; RPS19
R-HSA-2408557	Selenocysteine synthesis	8.32	1.82e-07	2.45e-05	10/85	RPS27; RPS18; RPS4X; RPL10; RPS24; RPL41; RPL13; RPL23; RPS28; RPS19
R-HSA-156842	Eukaryotic Translation Elongation	8.13	2.28e-07	2.45e-05	10/87	RPS27; RPS18; RPS4X; RPL10; RPS24; RPL41; RPL13; RPL23; RPS28; RPS19
R-HSA-72764	Eukaryotic Translation Termination	8.13	2.28e-07	2.45e-05	10/87	RPS27; RPS18; RPS4X; RPL10; RPS24; RPL41; RPL13; RPL23; RPS28; RPS19
R-HSA-975956	Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)	8.04	2.55e-07	2.45e-05	10/88	RPS27; RPS18; RPS4X; RPL10; RPS24; RPL41; RPL13; RPL23; RPS28; RPS19
R-HSA-72649	Translation initiation complex formation	7.72	1.02e-04	2.75e-03	6/55	RPS27; RPS18; RPS4X; RPS24; RPS28; RPS19
R-HSA-72702	Ribosomal scanning and start codon recognition	7.72	1.02e-04	2.75e-03	6/55	RPS27; RPS18; RPS4X; RPS24; RPS28; RPS19
R-HSA-2682334	EPH-Ephrin signaling	7.65	1.66e-03	3.43e-02	4/37	ARPC5; ACTB; ACTG1; MYL12A
R-HSA-72662	Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S	7.58	1.13e-04	2.96e-03	6/56	RPS27; RPS18; RPS4X; RPS24; RPS28; RPS19
R-HSA-72689	Formation of a pool of free 40S subunits	7.45	5.29e-07	4.59e-05	10/95	RPS27; RPS18; RPS4X; RPL10; RPS24; RPL41; RPL13; RPL23; RPS28; RPS19
R-HSA-2408522	Selenoamino acid metabolism	7.14	7.82e-07	6.17e-05	10/99	RPS27; RPS18; RPS4X; RPL10; RPS24; RPL41; RPL13; RPL23; RPS28; RPS19
R-HSA-156827	L13a-mediated translational silencing of Ceruloplasmin expression	6.74	1.36e-06	8.05e-05	10/105	RPS27; RPS18; RPS4X; RPL10; RPS24; RPL41; RPL13; RPL23; RPS28; RPS19
R-HSA-927802	Nonsense-Mediated Decay (NMD)	6.74	1.36e-06	8.05e-05	10/105	RPS27; RPS18; RPS4X; RPL10; RPS24; RPL41; RPL13; RPL23; RPS28; RPS19
R-HSA-975957	Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)	6.74	1.36e-06	8.05e-05	10/105	RPS27; RPS18; RPS4X; RPL10; RPS24; RPL41; RPL13; RPL23; RPS28; RPS19
R-HSA-72706	GTP hydrolysis and joining of the 60S ribosomal subunit	6.67	1.49e-06	8.05e-05	10/106	RPS27; RPS18; RPS4X; RPL10; RPS24; RPL41; RPL13; RPL23; RPS28; RPS19
R-HSA-1799339	SRP-dependent cotranslational protein targeting to membrane	6.67	1.49e-06	8.05e-05	10/106	RPS27; RPS18; RPS4X; RPL10; RPS24; RPL41; RPL13; RPL23; RPS28; RPS19
R-HSA-72613	Eukaryotic Translation Initiation	6.32	2.48e-06	1.13e-04	10/112	RPS27; RPS18; RPS4X; RPL10; RPS24; RPL41; RPL13; RPL23; RPS28; RPS19
R-HSA-72737	Cap-dependent Translation Initiation	6.32	2.48e-06	1.13e-04	10/112	RPS27; RPS18; RPS4X; RPL10; RPS24; RPL41; RPL13; RPL23; RPS28; RPS19
R-HSA-1236974	ER-Phagosome pathway	6.06	3.91e-04	9.68e-03	6/70	HLA-A; HLA-E; HLA-C; HLA-B; UBC; B2M
R-HSA-168273	Influenza Viral RNA Transcription and Replication	5.94	4.32e-06	1.78e-04	10/119	RPS27; RPS18; RPS4X; RPL10; RPS24; RPL41; RPL13; RPL23; RPS28; RPS19
R-HSA-1236975	Antigen processing-Cross presentation	5.66	5.68e-04	1.30e-02	6/75	HLA-A; HLA-E; HLA-C; HLA-B; UBC; B2M
R-HSA-168255	Influenza Life Cycle	5.53	8.37e-06	3.16e-04	10/128	RPS27; RPS18; RPS4X; RPL10; RPS24; RPL41; RPL13; RPL23; RPS28; RPS19
R-HSA-9010553	Regulation of expression of SLITs and ROBOs	5.29	4.21e-06	1.78e-04	11/147	RPS27; RPS18; RPS4X; RPL10; RPS24; RPL41; UBC; RPL13; RPL23; RPS28; RPS19
R-HSA-168254	Influenza Infection	5.16	1.54e-05	5.55e-04	10/137	RPS27; RPS18; RPS4X; RPL10; RPS24; RPL41; RPL13; RPL23; RPS28; RPS19
R-HSA-376176	Signaling by ROBO receptors	5.08	2.19e-06	1.12e-04	12/167	RPS27; CXCR4; RPS18; RPS4X; RPL10; RPS24; RPL41; UBC; RPL13; RPL23; RPS28; RPS19
R-HSA-422475	Axon guidance	4.72	2.84e-08	1.23e-05	17/255	RPS27; ARPC5; PTPRC; CXCR4; RPS18; ACTB; RPS4X; RPL10; RPS24; RPL41; UBC; RPL13; RPL23; ACTG1; MYL12A; RPS28; RPS19
R-HSA-6791226	Major pathway of rRNA processing in the nucleolus and cytosol	4.68	3.62e-05	1.16e-03	10/151	RPS27; RPS18; RPS4X; RPL10; RPS24; RPL41; RPL13; RPL23; RPS28; RPS19
R-HSA-913531	Interferon Signaling	4.63	6.59e-04	1.46e-02	7/107	GBP4; HLA-A; HLA-E; HLA-C; HLA-B; UBC; B2M
R-HSA-8868773	rRNA processing in the nucleus and cytosol	4.42	5.96e-05	1.78e-03	10/160	RPS27; RPS18; RPS4X; RPL10; RPS24; RPL41; RPL13; RPL23; RPS28; RPS19
R-HSA-72312	rRNA processing	4.26	8.17e-05	2.36e-03	10/166	RPS27; RPS18; RPS4X; RPL10; RPS24; RPL41; RPL13; RPL23; RPS28; RPS19
R-HSA-1266738	Developmental Biology	3.77	1.29e-07	2.45e-05	19/356	RPS27; ARPC5; PTPRC; H3F3A; CXCR4; HIST1H4C; RPS18; ACTB; RPS4X; RPL10; RPS24; RPL41; UBC; RPL13; RPL23; ACTG1; MYL12A; RPS28; RPS19
R-HSA-71291	Metabolism of amino acids and derivatives	3.48	4.32e-04	1.04e-02	10/203	RPS27; RPS18; RPS4X; RPL10; RPS24; RPL41; RPL13; RPL23; RPS28; RPS19
R-HSA-5663205	Infectious disease	3.10	1.70e-04	4.32e-03	13/297	RPS27; CXCR4; RPS18; RPS4X; RPL10; RPS24; RPL41; UBC; B2M; RPL13; RPL23; RPS28; RPS19

Factor 10 : 38 significant Reactome pathways

GeneSet	description	enrichRatio	pValue	FDR	GeneRatio	geneSymbols
R-HSA-202430	Translocation of ZAP-70 to Immunological synapse	16.90	3.38e-09	9.77e-07	8/14	HLA-DRA; HLA-DRB5; HLA-DRB1; HLA-DQB1; HLA-DPA1; HLA-DPB1; CD3D; CD3G
R-HSA-389948	PD-1 signaling	15.80	7.04e-09	1.53e-06	8/15	HLA-DRA; HLA-DRB5; HLA-DRB1; HLA-DQB1; HLA-DPA1; HLA-DPB1; CD3D; CD3G
R-HSA-202427	Phosphorylation of CD3 and TCR zeta chains	14.00	2.51e-08	4.36e-06	8/17	HLA-DRA; HLA-DRB5; HLA-DRB1; HLA-DQB1; HLA-DPA1; HLA-DPB1; CD3D; CD3G
R-HSA-202433	Generation of second messenger molecules	12.90	1.04e-09	4.52e-07	10/23	HLA-DRA; HLA-DRB5; HLA-DRB1; HLA-DQB1; HLA-DPA1; HLA-DPB1; CD3D; CD3G; EVL; LAT
R-HSA-198933	Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell	11.00	1.30e-13	1.12e-10	16/43	CD8A; CD8B; CD96; HLA-C; HLA-B; NCR3; JAML; CD3D; CD3G; ITGB1; CLEC2D; KLRD1; B2M; ICAM2; HCST; LAIR1
R-HSA-6783783	Interleukin-10 signaling	9.13	6.95e-04	1.94e-02	4/13	CCL5; CCL3; CCL4; CCL4L2
R-HSA-877300	Interferon gamma signaling	6.74	1.24e-06	1.53e-04	10/44	STAT1; HLA-C; HLA-B; HLA-DRA; HLA-DRB5; HLA-DRB1; HLA-DQB1; HLA-DPA1; HLA-DPB1; B2M
R-HSA-388841	Costimulation by the CD28 family	6.67	4.76e-06	5.16e-04	9/40	HLA-DRA; HLA-DRB5; HLA-DRB1; HLA-DQB1; HLA-DPA1; HLA-DPB1; CD3D; CD3G; PPP2R5C
R-HSA-373076	Class A/1 (Rhodopsin-like receptors)	6.18	1.02e-03	2.60e-02	5/24	CXCR4; LPAR6; GPR183; PTGER2; CCL5
R-HSA-2132295	MHC class II antigen presentation	5.18	5.70e-06	5.49e-04	11/63	KIF2A; CD74; HLA-DRA; HLA-DRB5; HLA-DRB1; HLA-DQB1; HLA-DPA1; HLA-DPB1; CTSD; CTSC; LAG3
R-HSA-202733	Cell surface interactions at the vascular wall	4.94	4.22e-04	1.31e-02	7/42	CD2; CD84; CD48; FCER1G; CD74; JAML; ITGB1
R-HSA-156902	Peptide chain elongation	3.88	9.41e-05	5.83e-03	11/84	RPS8; RPL5; RPL15; RPL14; RPL39; RPL35; RPS13; RPS24; RPL41; RPS15; RPS19
R-HSA-192823	Viral mRNA Translation	3.88	9.41e-05	5.83e-03	11/84	RPS8; RPL5; RPL15; RPL14; RPL39; RPL35; RPS13; RPS24; RPL41; RPS15; RPS19
R-HSA-2408557	Selenocysteine synthesis	3.84	1.05e-04	6.07e-03	11/85	RPS8; RPL5; RPL15; RPL14; RPL39; RPL35; RPS13; RPS24; RPL41; RPS15; RPS19
R-HSA-156842	Eukaryotic Translation Elongation	3.75	1.30e-04	6.64e-03	11/87	RPS8; RPL5; RPL15; RPL14; RPL39; RPL35; RPS13; RPS24; RPL41; RPS15; RPS19
R-HSA-72764	Eukaryotic Translation Termination	3.75	1.30e-04	6.64e-03	11/87	RPS8; RPL5; RPL15; RPL14; RPL39; RPL35; RPS13; RPS24; RPL41; RPS15; RPS19
R-HSA-72689	Formation of a pool of free 40S subunits	3.75	6.41e-05	5.05e-03	12/95	RPS8; RPL5; RPL15; RPL14; RPL39; RPL35; RPS13; RPS24; EIF3A; RPL41; RPS15; RPS19
R-HSA-975956	Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)	3.71	1.45e-04	6.97e-03	11/88	RPS8; RPL5; RPL15; RPL14; RPL39; RPL35; RPS13; RPS24; RPL41; RPS15; RPS19
R-HSA-418594	G alpha (i) signalling events	3.54	1.63e-03	3.94e-02	8/67	CXCR4; RGS10; GPR183; CCL5; CCL4; CCL4L2; PDE6G
R-HSA-156827	L13a-mediated translational silencing of Ceruloplasmin expression	3.39	1.72e-04	7.84e-03	12/105	RPS8; RPL5; RPL15; RPL14; RPL39; RPL35; RPS13; RPS24; EIF3A; RPL41; RPS15; RPS19
R-HSA-72706	GTP hydrolysis and joining of the 60S ribosomal subunit	3.36	1.88e-04	8.12e-03	12/106	RPS8; RPL5; RPL15; RPL14; RPL39; RPL35; RPS13; RPS24; EIF3A; RPL41; RPS15; RPS19
R-HSA-913531	Interferon Signaling	3.33	2.06e-04	8.12e-03	12/107	STAT1; HLA-C; HLA-B; HLA-DRA; HLA-DRB5; HLA-DRB1; HLA-DQB1; HLA-DPA1; HLA-DPB1; IFITM2; B2M; BST2
R-HSA-202403	TCR signaling	3.30	4.16e-04	1.31e-02	11/99	TRAT1; HLA-DRA; HLA-DRB5; HLA-DRB1; HLA-DQB1; HLA-DPA1; HLA-DPB1; CD3D; CD3G; EVL; LAT
R-HSA-2408522	Selenoamino acid metabolism	3.30	4.16e-04	1.31e-02	11/99	RPS8; RPL5; RPL15; RPL14; RPL39; RPL35; RPS13; RPS24; RPL41; RPS15; RPS19
R-HSA-202424	Downstream TCR signaling	3.22	1.68e-03	3.94e-02	9/83	TRAT1; HLA-DRA; HLA-DRB5; HLA-DRB1; HLA-DQB1; HLA-DPA1; HLA-DPB1; CD3D; CD3G
R-HSA-72613	Eukaryotic Translation Initiation	3.18	3.18e-04	1.10e-02	12/112	RPS8; RPL5; RPL15; RPL14; RPL39; RPL35; RPS13; RPS24; EIF3A; RPL41; RPS15; RPS19
R-HSA-72737	Cap-dependent Translation Initiation	3.18	3.18e-04	1.10e-02	12/112	RPS8; RPL5; RPL15; RPL14; RPL39; RPL35; RPS13; RPS24; EIF3A; RPL41; RPS15; RPS19
R-HSA-388396	GPCR downstream signalling	3.13	2.03e-04	8.12e-03	13/123	RHOC; CXCR4; ARHGEF12; RGS10; LPAR6; GPR183; PTGER2; PRKCB; CCL5; CCL4; CCL4L2; PDE6G
R-HSA-927802	Nonsense-Mediated Decay (NMD)	3.11	6.92e-04	1.94e-02	11/105	RPS8; RPL5; RPL15; RPL14; RPL39; RPL35; RPS13; RPS24; RPL41; RPS15; RPS19
R-HSA-975957	Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)	3.11	6.92e-04	1.94e-02	11/105	RPS8; RPL5; RPL15; RPL14; RPL39; RPL35; RPS13; RPS24; RPL41; RPS15; RPS19
R-HSA-372790	Signaling by GPCR	3.08	2.39e-04	9.02e-03	13/125	RHOC; CXCR4; ARHGEF12; RGS10; LPAR6; GPR183; PTGER2; PRKCB; CCL5; CCL4; CCL4L2; PDE6G
R-HSA-1799339	SRP-dependent cotranslational protein targeting to membrane	3.08	7.50e-04	1.97e-02	11/106	RPS8; RPL5; RPL15; RPL14; RPL39; RPL35; RPS13; RPS24; RPL41; RPS15; RPS19
R-HSA-109582	Hemostasis	2.78	3.57e-05	3.09e-03	19/203	CD2; CD84; CD48; FCER1G; DOCK10; ITGA1; KIF2A; CD74; PHACTR2; CTSW; JAML; ITGB1; CD9; CD63; ATP2B1; PPP2R5C; PRKCB; LAT; RAC2
R-HSA-168273	Influenza Viral RNA Transcription and Replication	2.74	1.96e-03	4.47e-02	11/119	RPS8; RPL5; RPL15; RPL14; RPL39; RPL35; RPS13; RPS24; RPL41; RPS15; RPS19
R-HSA-1280218	Adaptive Immune System	2.56	5.96e-08	8.61e-06	35/405	CD8A; CD8B; TRAT1; CD96; KIF2A; CD74; HLA-C; HLA-B; NCR3; HLA-DRA; HLA-DRB5; HLA-DRB1; HLA-DQB1; HLA-DPA1; HLA-DPB1; MKRN1; CTSD; CTSC; JAML; CD3D; CD3G; ITGB1; LAG3; CLEC2D; KLRD1; EVL; PPP2R5C; B2M; PRKCB; LAT; ICAM2; YWHAB; HCST; LAIR1; NCF4
R-HSA-376176	Signaling by ROBO receptors	2.49	1.26e-03	3.13e-02	14/167	RPS8; RPL5; CXCR4; SRGAP3; RPL15; RPL14; RPL39; RPL35; RPS13; RPS24; RPL41; EVL; RPS15; RPS19
R-HSA-1280215	Cytokine Signaling in Immune system	2.26	9.37e-05	5.83e-03	24/315	PTPN7; STAT1; HAVCR2; HLA-C; HLA-B; LTB; HLA-DRA; HLA-DRB5; HLA-DRB1; HLA-DQB1; HLA-DPA1; HLA-DPB1; IFITM2; BIRC3; IL2RA; ITGB1; CD27; B2M; IL16; CCL5; CCL3; CCL4; CCL4L2; BST2
R-HSA-422475	Axon guidance	2.21	7.36e-04	1.97e-02	19/255	RPS8; RPL5; RHOC; CXCR4; SRGAP3; RPL15; RPL14; ITGA1; EZR; RPL39; RPL35; RPS13; ARHGEF12; ITGB1; RPS24; RPL41; EVL; RPS15; RPS19

Factor 11 : 38 significant Reactome pathways

GeneSet	description	enrichRatio	pValue	FDR	GeneRatio	geneSymbols
R-HSA-202430	Translocation of ZAP-70 to Immunological synapse	17.80	2.27e-09	1.97e-06	8/14	PTPN22; HLA-DRA; HLA-DRB5; HLA-DRB1; HLA-DQA1; HLA-DQB1; HLA-DPA1; HLA-DPB1
R-HSA-202427	Phosphorylation of CD3 and TCR zeta chains	14.70	1.69e-08	4.89e-06	8/17	PTPN22; HLA-DRA; HLA-DRB5; HLA-DRB1; HLA-DQA1; HLA-DQB1; HLA-DPA1; HLA-DPB1
R-HSA-389948	PD-1 signaling	14.50	1.52e-07	2.64e-05	7/15	HLA-DRA; HLA-DRB5; HLA-DRB1; HLA-DQA1; HLA-DQB1; HLA-DPA1; HLA-DPB1
R-HSA-6783783	Interleukin-10 signaling	14.40	1.37e-06	1.98e-04	6/13	IL10RA; CCL5; CCL3; CCL4; CCL3L3
R-HSA-202433	Generation of second messenger molecules	12.20	1.49e-08	4.89e-06	9/23	FYB; HLA-DRA; HLA-DRB5; HLA-DRB1; HLA-DQA1; HLA-DQB1; HLA-DPA1; HLA-DPB1; LAT
R-HSA-375276	Peptide ligand-binding receptors	10.40	4.08e-04	1.40e-02	4/12	CXCR6; CXCR3; ANXA1; CCL5
R-HSA-373076	Class A/1 (Rhodopsin-like receptors)	7.79	8.05e-05	6.35e-03	6/24	CXCR6; CXCR3; P2RY10; ANXA1; GPR65; CCL5
R-HSA-8982491	Glycogen metabolism	7.79	1.36e-03	3.27e-02	4/16	RPS27A; GYG1; CALM1
R-HSA-425393	Transport of inorganic cations/anions and amino acids/oligopeptides	7.33	1.73e-03	4.06e-02	4/17	SLC1A4; SLC4A7; CALM1
R-HSA-500792	GPCR ligand binding	5.84	4.39e-04	1.40e-02	6/32	CXCR6; CXCR3; P2RY10; ANXA1; GPR65; CCL5
R-HSA-198933	Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell	5.80	5.01e-05	5.17e-03	8/43	CD8A; CD8B; ITGA4; NCR3; JAML; ITGB1; KLRG1; KLRB1
R-HSA-877300	Interferon gamma signaling	5.67	5.96e-05	5.17e-03	8/44	HLA-DRA; HLA-DRB5; HLA-DRB1; HLA-DQA1; HLA-DQB1; HLA-DPA1; HLA-DPB1; IFNGR1
R-HSA-388841	Costimulation by the CD28 family	5.45	2.27e-04	1.31e-02	7/40	HLA-DRA; HLA-DRB5; HLA-DRB1; HLA-DQA1; HLA-DQB1; HLA-DPA1; HLA-DPB1
R-HSA-72695	Formation of the ternary complex, and subsequently, the 43S complex	5.19	1.14e-04	7.06e-03	8/48	RPS27A; RPSA; RPS18; RPS20; RPS24; RPS2; RPS15A; RPS5
R-HSA-202733	Cell surface interactions at the vascular wall	5.19	3.11e-04	1.34e-02	7/42	CD2; CD84; ITGA4; CD74; JAML; ITGB1; TGFB1
R-HSA-72649	Translation initiation complex formation	5.10	4.87e-05	5.17e-03	9/55	RPS27A; RPSA; RPS18; RPS20; PABPC1; RPS24; RPS2; RPS15A; RPS5
R-HSA-72662	Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S	5.01	5.65e-05	5.17e-03	9/56	RPS27A; RPSA; RPS18; RPS20; PABPC1; RPS24; RPS2; RPS15A; RPS5
R-HSA-72702	Ribosomal scanning and start codon recognition	4.53	3.05e-04	1.34e-02	8/55	RPS27A; RPSA; RPS18; RPS20; RPS24; RPS2; RPS15A; RPS5
R-HSA-2132295	MHC class II antigen presentation	3.96	7.83e-04	2.03e-02	8/63	CD74; HLA-DRA; HLA-DRB5; HLA-DRB1; HLA-DQA1; HLA-DQB1; HLA-DPA1; HLA-DPB1
R-HSA-975956	Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)	3.90	9.21e-05	6.41e-03	11/88	RPS27A; RPSA; RPS18; RPL39; RPS20; PABPC1; RPS24; RPS2; RPS15A; RPL13A; RPS5
R-HSA-156902	Peptide chain elongation	3.71	2.93e-04	1.34e-02	10/84	RPS27A; RPSA; RPS18; RPL39; RPS20; RPS24; RPS2; RPS15A; RPL13A; RPS5
R-HSA-192823	Viral mRNA Translation	3.71	2.93e-04	1.34e-02	10/84	RPS27A; RPSA; RPS18; RPL39; RPS20; RPS24; RPS2; RPS15A; RPL13A; RPS5
R-HSA-2408557	Selenocysteine synthesis	3.67	3.23e-04	1.34e-02	10/85	RPS27A; RPSA; RPS18; RPL39; RPS20; RPS24; RPS2; RPS15A; RPL13A; RPS5
R-HSA-156842	Eukaryotic Translation Elongation	3.58	3.92e-04	1.40e-02	10/87	RPS27A; RPSA; RPS18; RPL39; RPS20; RPS24; RPS2; RPS15A; RPL13A; RPS5
R-HSA-72764	Eukaryotic Translation Termination	3.58	3.92e-04	1.40e-02	10/87	RPS27A; RPSA; RPS18; RPL39; RPS20; RPS24; RPS2; RPS15A; RPL13A; RPS5
R-HSA-202403	TCR signaling	3.46	2.69e-04	1.34e-02	11/99	PTPN22; RPS27A; FYB; HLA-DRA; HLA-DRB5; HLA-DRB1; HLA-DQA1; HLA-DQB1; HLA-DPA1; HLA-DPB1; LAT
R-HSA-72689	Formation of a pool of free 40S subunits	3.28	7.97e-04	2.03e-02	10/95	RPS27A; RPSA; RPS18; RPL39; RPS20; RPS24; RPS2; RPS15A; RPL13A; RPS5
R-HSA-156827	L13a-mediated translational silencing of Ceruloplasmin expression	3.27	4.52e-04	1.40e-02	11/105	RPS27A; RPSA; RPS18; RPL39; RPS20; PABPC1; RPS24; RPS2; RPS15A; RPL13A; RPS5
R-HSA-927802	Nonsense-Mediated Decay (NMD)	3.27	4.52e-04	1.40e-02	11/105	RPS27A; RPSA; RPS18; RPL39; RPS20; PABPC1; RPS24; RPS2; RPS15A; RPL13A; RPS5
R-HSA-975957	Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)	3.27	4.52e-04	1.40e-02	11/105	RPS27A; RPSA; RPS18; RPL39; RPS20; PABPC1; RPS24; RPS2; RPS15A; RPL13A; RPS5
R-HSA-1799339	SRP-dependent cotranslational protein targeting to membrane	3.23	4.91e-04	1.47e-02	11/106	RPS27A; RPSA; RPS18; RPL39; RPS20; RPS24; SRP14; RPS2; RPS15A; RPL13A; RPS5
R-HSA-913531	Interferon Signaling	3.20	5.32e-04	1.54e-02	11/107	RPS27A; HLA-DRA; HLA-DRB5; HLA-DRB1; HLA-DQA1; HLA-DQB1; HLA-DPA1; HLA-DPB1; IFNGR1; IFITM2; ISG20
R-HSA-2408522	Selenoamino acid metabolism	3.15	1.10e-03	2.73e-02	10/99	RPS27A; RPSA; RPS18; RPL39; RPS20; RPS24; RPS2; RPS15A; RPL13A; RPS5
R-HSA-72613	Eukaryotic Translation Initiation	3.06	7.87e-04	2.03e-02	11/112	RPS27A; RPSA; RPS18; RPL39; RPS20; PABPC1; RPS24; RPS2; RPS15A; RPL13A; RPS5
R-HSA-72737	Cap-dependent Translation Initiation	3.06	7.87e-04	2.03e-02	11/112	RPS27A; RPSA; RPS18; RPL39; RPS20; PABPC1; RPS24; RPS2; RPS15A; RPL13A; RPS5
R-HSA-1280215	Cytokine Signaling in Immune system	2.97	2.32e-08	5.02e-06	30/315	JUN; RPS27A; STAT4; LTB; HLA-DRA; HLA-DRB5; HLA-DRB1; HLA-DQA1; HLA-DQB1; HLA-DPA1; HLA-DPB1; IFNGR1; CEBPD; ANXA1; IFITM2; CASP1; IL10RA; ITGB1; PDCD4; CD27; LCP1; RORA; ISG20; IL32; CCL5; CCL3; CCL4; CCL3L3; TGFB1
R-HSA-72706	GTP hydrolysis and joining of the 60S ribosomal subunit	2.94	1.87e-03	4.26e-02	10/106	RPS27A; RPSA; RPS18; RPL39; RPS20; RPS24; RPS2; RPS15A; RPL13A; RPS5
R-HSA-449147	Signaling by Interleukins	2.67	9.61e-05	6.41e-03	18/210	JUN; RPS27A; STAT4; CEBPD; ANXA1; CASP1; IL10RA; ITGB1; PDCD4; LCP1; RORA; IL32; CCL5; CCL3; CCL4; CCL3L3; TGFB1

Factor 12 : 53 significant Reactome pathways

GeneSet	description	enrichRatio	pValue	FDR	GeneRatio	geneSymbols
R-HSA-3928662	EPHB-mediated forward signaling	27.00	5.43e-12	4.71e-09	9/17	CDC42; ARPC5; ACTR3; ARPC2; FYN; ACTB; ARPC1B; CFL1; ACTG1
R-HSA-6783783	Interleukin-10 signaling	15.70	8.45e-05	2.30e-03	4/13	IL10RA; CCL5; CCL3L3
R-HSA-2682334	EPH-Ephrin signaling	15.20	4.21e-11	1.83e-08	11/37	CDC42; ARPC5; ACTR3; ARPC2; FYN; ACTB; ARPC1B; CFL1; MYL6; ACTG1; MYL12A
R-HSA-5663213	RHO GTPases Activate WASPs and WAVEs	14.30	2.98e-07	4.30e-05	7/25	CDC42; ARPC5; ACTR3; ARPC2; ACTB; ARPC1B; ACTG1
R-HSA-5627117	RHO GTPases Activate ROCKs	13.90	1.06e-03	2.09e-02	3/11	CFL1; MYL6; MYL12A
R-HSA-446353	Cell-extracellular matrix interactions	13.90	1.06e-03	2.09e-02	3/11	ACTB; ACTN1; ACTG1
R-HSA-2172127	DAP12 interactions	13.40	2.35e-05	1.07e-03	5/19	FYN; KLRD1; KLRC2; B2M; GRAP2
R-HSA-2424491	DAP12 signaling	13.40	2.35e-05	1.07e-03	5/19	FYN; KLRD1; KLRC2; B2M; GRAP2
R-HSA-375276	Peptide ligand-binding receptors	12.80	1.39e-03	2.52e-02	3/12	CXCR3; CCL5; CCR7
R-HSA-2029482	Regulation of actin dynamics for phagocytic cup formation	11.00	3.56e-07	4.41e-05	8/37	CDC42; ARPC5; ACTR3; ARPC2; ACTB; ARPC1B; CFL1; ACTG1
R-HSA-446728	Cell junction organization	10.90	2.24e-03	3.81e-02	3/14	ACTB; ACTN1; ACTG1
R-HSA-5627123	RHO GTPases activate PAKs	10.90	2.24e-03	3.81e-02	3/14	CDC42; MYL6; MYL12A
R-HSA-373076	Class A/1 (Rhodopsin-like receptors)	10.60	7.95e-05	2.30e-03	5/24	CXCR3; LPAR6; PTGER2; CCL5; CCR7
R-HSA-2029480	Fcgamma receptor (FCGR) dependent phagocytosis	10.20	1.28e-07	2.22e-05	9/45	CDC42; ARPC5; ACTR3; ARPC2; FYN; ACTB; ARPC1B; CFL1; ACTG1
R-HSA-373755	Semaphorin interactions	8.88	9.02e-04	1.96e-02	4/23	FYN; CFL1; MYL6; MYL12A
R-HSA-1500931	Cell-Cell communication	7.98	3.33e-04	8.03e-03	5/32	FYB; FYN; ACTB; ACTN1; ACTG1
R-HSA-500792	GPCR ligand binding	7.98	3.33e-04	8.03e-03	5/32	CXCR3; LPAR6; PTGER2; CCL5; CCR7
R-HSA-9020591	Interleukin-12 signaling	7.09	5.87e-04	1.34e-02	5/36	CDC42; CFL1; RPLP0; LCP1; P4HB
R-HSA-8950505	Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation	6.59	2.85e-03	4.66e-02	4/31	CDC42; CFL1; RPLP0; LCP1
R-HSA-156902	Peptide chain elongation	6.08	3.80e-06	3.66e-04	10/84	RPL12; RPS3; RPS26; RPL41; RPLP0; RPL36AL; RPS15A; RPS19; RPL13A; RPL3
R-HSA-192823	Viral mRNA Translation	6.08	3.80e-06	3.66e-04	10/84	RPL12; RPS3; RPS26; RPL41; RPLP0; RPL36AL; RPS15A; RPS19; RPL13A; RPL3
R-HSA-447115	Interleukin-12 family signaling	6.08	1.21e-03	2.33e-02	5/42	CDC42; CFL1; RPLP0; LCP1; P4HB
R-HSA-2408557	Selenocysteine synthesis	6.01	4.24e-06	3.68e-04	10/85	RPL12; RPS3; RPS26; RPL41; RPLP0; RPL36AL; RPS15A; RPS19; RPL13A; RPL3
R-HSA-198933	Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell	5.94	1.35e-03	2.49e-02	5/43	SLAMF7; ITGA4; KLRD1; KLRC1; B2M
R-HSA-156842	Eukaryotic Translation Elongation	5.87	5.25e-06	3.80e-04	10/87	RPL12; RPS3; RPS26; RPL41; RPLP0; RPL36AL; RPS15A; RPS19; RPL13A; RPL3
R-HSA-72764	Eukaryotic Translation Termination	5.87	5.25e-06	3.80e-04	10/87	RPL12; RPS3; RPS26; RPL41; RPLP0; RPL36AL; RPS15A; RPS19; RPL13A; RPL3
R-HSA-975956	Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)	5.80	5.83e-06	3.89e-04	10/88	RPL12; RPS3; RPS26; RPL41; RPLP0; RPL36AL; RPS15A; RPS19; RPL13A; RPL3
R-HSA-72689	Formation of a pool of free 40S subunits	5.38	1.17e-05	6.77e-04	10/95	RPL12; RPS3; RPS26; RPL41; RPLP0; RPL36AL; RPS15A; RPS19; RPL13A; RPL3
R-HSA-2408522	Selenoamino acid metabolism	5.16	1.70e-05	8.65e-04	10/99	RPL12; RPS3; RPS26; RPL41; RPLP0; RPL36AL; RPS15A; RPS19; RPL13A; RPL3
R-HSA-114608	Platelet degranulation	5.11	2.67e-03	4.45e-02	5/50	CAP1; TMSB4X; CFL1; ACTN1; PFN1
R-HSA-156827	L13a-mediated translational silencing of Ceruloplasmin expression	4.87	2.86e-05	1.08e-03	10/105	RPL12; RPS3; RPS26; RPL41; RPLP0; RPL36AL; RPS15A; RPS19; RPL13A; RPL3
R-HSA-927802	Nonsense-Mediated Decay (NMD)	4.87	2.86e-05	1.08e-03	10/105	RPL12; RPS3; RPS26; RPL41; RPLP0; RPL36AL; RPS15A; RPS19; RPL13A; RPL3
R-HSA-975957	Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)	4.87	2.86e-05	1.08e-03	10/105	RPL12; RPS3; RPS26; RPL41; RPLP0; RPL36AL; RPS15A; RPS19; RPL13A; RPL3
R-HSA-72706	GTP hydrolysis and joining of the 60S ribosomal subunit	4.82	3.11e-05	1.08e-03	10/106	RPL12; RPS3; RPS26; RPL41; RPLP0; RPL36AL; RPS15A; RPS19; RPL13A; RPL3
R-HSA-1799339	SRP-dependent cotranslational protein targeting to membrane	4.82	3.11e-05	1.08e-03	10/106	RPL12; RPS3; RPS26; RPL41; RPLP0; RPL36AL; RPS15A; RPS19; RPL13A; RPL3
R-HSA-422475	Axon guidance	4.61	1.50e-10	4.35e-08	23/255	CDC42; CAP1; ARPC5; ACTR3; ARPC2; FYN; ACTB; ARPC1B; RPL12; CFL1; RPS3; RPS26; RPL41; MYL6; RPLP0; RPL36AL; RPS15A; PFN1; ACTG1; MYL12A; RPS19; RPL13A; RPL3
R-HSA-72613	Eukaryotic Translation Initiation	4.56	5.03e-05	1.56e-03	10/112	RPL12; RPS3; RPS26; RPL41; RPLP0; RPL36AL; RPS15A; RPS19; RPL13A; RPL3
R-HSA-72737	Cap-dependent Translation Initiation	4.56	5.03e-05	1.56e-03	10/112	RPL12; RPS3; RPS26; RPL41; RPLP0; RPL36AL; RPS15A; RPS19; RPL13A; RPL3
R-HSA-195258	RHO GTPase Effectors	4.54	8.54e-06	5.29e-04	12/135	CDC42; ARPC5; ACTR3; ARPC2; ACTB; ARPC1B; CFL1; MYL6; PFN1; ACTG1; MYL12A; RAC2
R-HSA-168273	Influenza Viral RNA Transcription and Replication	4.29	8.47e-05	2.30e-03	10/119	RPL12; RPS3; RPS26; RPL41; RPLP0; RPL36AL; RPS15A; RPS19; RPL13A; RPL3
R-HSA-168255	Influenza Life Cycle	3.99	1.57e-04	4.12e-03	10/128	RPL12; RPS3; RPS26; RPL41; RPLP0; RPL36AL; RPS15A; RPS19; RPL13A; RPL3
R-HSA-376176	Signaling by ROBO receptors	3.98	1.49e-05	8.08e-04	13/167	CDC42; CAP1; RPL12; RPS3; RPS26; RPL41; RPLP0; RPL36AL; RPS15A; PFN1; RPS19; RPL13A; RPL3
R-HSA-76002	Platelet activation, signaling and aggregation	3.86	9.46e-04	1.97e-02	8/106	CDC42; CAP1; FYN; TMSB4X; CFL1; ACTN1; PFN1; RAC2
R-HSA-194315	Signaling by Rho GTPases	3.77	2.63e-05	1.08e-03	13/176	CDC42; ARPC5; ACTR3; ARPC2; ACTB; ARPC1B; CFL1; ARHGDIB; MYL6; PFN1; ACTG1; MYL12A; RAC2
R-HSA-168254	Influenza Infection	3.73	2.75e-04	7.02e-03	10/137	RPL12; RPS3; RPS26; RPL41; RPLP0; RPL36AL; RPS15A; RPS19; RPL13A; RPL3
R-HSA-9010553	Regulation of expression of SLITs and ROBOs	3.48	4.88e-04	1.14e-02	10/147	RPL12; RPS3; RPS26; RPL41; RPLP0; RPL36AL; RPS15A; RPS19; RPL13A; RPL3
R-HSA-449147	Signaling by Interleukins	3.41	3.95e-05	1.32e-03	14/210	CDC42; HAVCR2; FYN; CFL1; IL10RA; VIM; RPLP0; LCP1; RORA; CCL5; CCL3L3; P4HB; IL2RB
R-HSA-6791226	Major pathway of rRNA processing in the nucleolus and cytosol	3.38	6.04e-04	1.34e-02	10/151	RPL12; RPS3; RPS26; RPL41; RPLP0; RPL36AL; RPS15A; RPS19; RPL13A; RPL3
R-HSA-1266738	Developmental Biology	3.30	1.08e-07	2.22e-05	23/356	CDC42; CAP1; ARPC5; ACTR3; ARPC2; FYN; ACTB; ARPC1B; RPL12; CFL1; RPS3; RPS26; RPL41; MYL6; RPLP0; RPL36AL; RPS15A; PFN1; ACTG1; MYL12A; RPS19; RPL13A; RPL3
R-HSA-8868773	rRNA processing in the nucleus and cytosol	3.19	9.52e-04	1.97e-02	10/160	RPL12; RPS3; RPS26; RPL41; RPLP0; RPL36AL; RPS15A; RPS19; RPL13A; RPL3
R-HSA-72312	rRNA processing	3.08	1.27e-03	2.39e-02	10/166	RPL12; RPS3; RPS26; RPL41; RPLP0; RPL36AL; RPS15A; RPS19; RPL13A; RPL3
R-HSA-109582	Hemostasis	2.77	1.70e-03	3.01e-02	11/203	CAPZB; CDC42; CAP1; ITGA4; FYN; ACTB; TMSB4X; CFL1; ACTN1; PFN1; RAC2
R-HSA-1280215	Cytokine Signaling in Immune system	2.76	8.04e-05	2.30e-03	17/315	CDC42; GBP1; HAVCR2; LTB; FYN; CFL1; IL10RA; VIM; RPLP0; LCP1; B2M; RORA; CCL5; CCL3L3; P4HB; IL2RB

Factor 13 : 23 significant Reactome pathways

GeneSet	description	enrichRatio	pValue	FDR	GeneRatio	geneSymbols
R-HSA-6783783	Interleukin-10 signaling	22.00	6.33e-09	1.37e-06	7/13	TNFRSF1B; TIMP1; CCL3; CCL4; CCL3L3; CCL4L2
R-HSA-202430	Translocation of ZAP-70 to Immunological synapse	20.40	1.24e-08	1.79e-06	7/14	HLA-DRA; HLA-DRB5; HLA-DRB1; HLA-DQA1; HLA-DQB1; HLA-DPA1; HLA-DPB1
R-HSA-389948	PD-1 signaling	19.10	2.28e-08	2.83e-06	7/15	HLA-DRA; HLA-DRB5; HLA-DRB1; HLA-DQA1; HLA-DQB1; HLA-DPA1; HLA-DPB1
R-HSA-202427	Phosphorylation of CD3 and TCR zeta chains	16.80	6.62e-08	6.38e-06	7/17	HLA-DRA; HLA-DRB5; HLA-DRB1; HLA-DQA1; HLA-DQB1; HLA-DPA1; HLA-DPB1
R-HSA-198933	Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell	15.20	6.66e-16	5.78e-13	16/43	SLAMF7; SELL; CD96; HLA-A; HLA-E; HLA-C; HLA-B; SH2D1A; CD81; JAML; CRTAM; KLRG1; KLRC1; ITGB7; CD226; ITGB2
R-HSA-202433	Generation of second messenger molecules	14.20	3.41e-08	3.70e-06	8/23	HLA-DRA; HLA-DRB5; HLA-DRB1; HLA-DQA1; HLA-DQB1; HLA-DPA1; HLA-DPB1; EVL
R-HSA-877300	Interferon gamma signaling	10.20	4.01e-09	1.16e-06	11/44	HLA-A; HLA-E; HLA-C; HLA-B; HLA-DRA; HLA-DRB5; HLA-DRB1; HLA-DQA1; HLA-DQB1; HLA-DPA1; HLA-DPB1
R-HSA-983170	Antigen Presentation: Folding, assembly and peptide loading of class I MHC	8.17	1.20e-03	4.70e-02	4/20	HLA-A; HLA-E; HLA-C; HLA-B
R-HSA-388841	Costimulation by the CD28 family	7.15	4.01e-05	2.90e-03	7/40	HLA-DRA; HLA-DRB5; HLA-DRB1; HLA-DQA1; HLA-DQB1; HLA-DPA1; HLA-DPB1
R-HSA-2132295	MHC class II antigen presentation	7.14	2.20e-07	1.91e-05	11/63	CD74; HLA-DRA; HLA-DRB5; HLA-DRB1; HLA-DQA1; HLA-DQB1; HLA-DMB; HLA-DPA1; HLA-DPB1; CTSC; LAG3
R-HSA-909733	Interferon alpha/beta signaling	6.39	9.38e-04	4.06e-02	5/32	HLA-A; HLA-E; HLA-C; HLA-B; IFITM2
R-HSA-6785807	Interleukin-4 and Interleukin-13 signaling	6.01	1.25e-03	4.70e-02	5/34	TNFRSF1B; TIMP1; CEBPD; VIM; ITGB2
R-HSA-202733	Cell surface interactions at the vascular wall	5.84	4.69e-04	2.71e-02	6/42	FCER1G; SELL; SOS1; CD74; JAML; ITGB2
R-HSA-913531	Interferon Signaling	4.58	8.12e-06	6.40e-04	12/107	HLA-A; HLA-E; HLA-C; HLA-B; HLA-DRA; HLA-DRB5; HLA-DRB1; HLA-DQA1; HLA-DQB1; HLA-DPA1; HLA-DPB1; IFITM2
R-HSA-418594	G alpha (i) signalling events	4.27	1.09e-03	4.52e-02	7/67	RGS1; CXCR4; RGS10; CCL4; CCL4L2; CCR7
R-HSA-202424	Downstream TCR signaling	3.94	8.26e-04	3.77e-02	8/83	HLA-DRA; HLA-DRB5; HLA-DRB1; HLA-DQA1; HLA-DQB1; PSMB9; HLA-DPA1; HLA-DPB1
R-HSA-202403	TCR signaling	3.72	5.97e-04	3.23e-02	9/99	HLA-DRA; HLA-DRB5; HLA-DRB1; HLA-DQA1; HLA-DQB1; PSMB9; HLA-DPA1; HLA-DPB1; EVL
R-HSA-1280215	Cytokine Signaling in Immune system	3.63	4.75e-10	2.06e-07	28/315	TNFRSF1B; PTPN7; SOS1; HLA-A; HLA-E; HLA-C; HLA-B; HLA-DRA; HLA-DRB5; HLA-DRB1; HLA-DQA1; HLA-DQB1; PSMB9; HLA-DPA1; HLA-DPB1; TIMP1; CEBPD; IFITM2; VIM; CD27; HMGB1; IL32; CCL3; CCL4; CCL3L3; CCL4L2; ITGB2
R-HSA-388396	GPCR downstream signalling	3.32	7.19e-04	3.67e-02	10/123	RGS1; SOS1; CXCR4; F2R; ARHGEF12; RGS10; CCL4; CCL4L2; CCR7
R-HSA-372790	Signaling by GPCR	3.27	8.16e-04	3.77e-02	10/125	RGS1; SOS1; CXCR4; F2R; ARHGEF12; RGS10; CCL4; CCL4L2; CCR7
R-HSA-1280218	Adaptive Immune System	3.03	8.22e-09	1.43e-06	30/405	SLAMF7; SELL; SOS1; CD96; CD74; HLA-A; HLA-E; HLA-C; HLA-B; HLA-DRA; HLA-DRB5; HLA-DRB1; HLA-DQA1; HLA-DQB1; PSMB9; HLA-DMB; HLA-DPA1; HLA-DPB1; SH2D1A; CD81; CTSC; JAML; CRTAM; LAG3; KLRG1; KLRC1; ITGB7; EVL; CD226; ITGB2
R-HSA-109582	Hemostasis	3.02	9.20e-05	6.13e-03	15/203	S100A10; FCER1G; SELL; SOS1; PLEK; ITGA1; F2R; CD74; TMSB4X; TIMP1; JAML; SRGN; ATP2B1; P2RX4; ITGB2
R-HSA-449147	Signaling by Interleukins	2.92	1.35e-04	8.39e-03	15/210	TNFRSF1B; PTPN7; SOS1; PSMB9; TIMP1; CEBPD; VIM; HMGB1; IL32; CCL3; CCL4; CCL3L3; CCL4L2; ITGB2

Factor 14 : 22 significant Reactome pathways

GeneSet	description	enrichRatio	pValue	FDR	GeneRatio	geneSymbols
R-HSA-877300	Interferon gamma signaling	7.60	6.83e-06	0.002963	8/44	GBP4; STAT1; HLA-B; HLA-DRA; HLA-DQA1; CD44; PTPN6; MT2A
R-HSA-6785807	Interleukin-4 and Interleukin-13 signaling	6.15	1.13e-03	0.046482	5/34	STAT1; IL2RG; HIF1A; JUNB; ITGB2
R-HSA-156902	Peptide chain elongation	4.98	2.37e-05	0.003889	10/84	RPL15; RPS18; RPL39; RPLP2; RPS26; RPL6; RPLP1; RPS21; RPL18A; RPS9
R-HSA-192823	Viral mRNA Translation	4.98	2.37e-05	0.003889	10/84	RPL15; RPS18; RPL39; RPLP2; RPS26; RPL6; RPLP1; RPS21; RPL18A; RPS9
R-HSA-2408557	Selenocysteine synthesis	4.92	2.64e-05	0.003889	10/85	RPL15; RPS18; RPL39; RPLP2; RPS26; RPL6; RPLP1; RPS21; RPL18A; RPS9
R-HSA-156842	Eukaryotic Translation Elongation	4.80	3.24e-05	0.003889	10/87	RPL15; RPS18; RPL39; RPLP2; RPS26; RPL6; RPLP1; RPS21; RPL18A; RPS9
R-HSA-72764	Eukaryotic Translation Termination	4.80	3.24e-05	0.003889	10/87	RPL15; RPS18; RPL39; RPLP2; RPS26; RPL6; RPLP1; RPS21; RPL18A; RPS9
R-HSA-975956	Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)	4.75	3.59e-05	0.003889	10/88	RPL15; RPS18; RPL39; RPLP2; RPS26; RPL6; RPLP1; RPS21; RPL18A; RPS9
R-HSA-72689	Formation of a pool of free 40S subunits	4.40	7.00e-05	0.006747	10/95	RPL15; RPS18; RPL39; RPLP2; RPS26; RPL6; RPLP1; RPS21; RPL18A; RPS9
R-HSA-2408522	Selenoamino acid metabolism	4.22	9.98e-05	0.008655	10/99	RPL15; RPS18; RPL39; RPLP2; RPS26; RPL6; RPLP1; RPS21; RPL18A; RPS9
R-HSA-156827	L13a-mediated translational silencing of Ceruloplasmin expression	3.98	1.64e-04	0.010283	10/105	RPL15; RPS18; RPL39; RPLP2; RPS26; RPL6; RPLP1; RPS21; RPL18A; RPS9
R-HSA-927802	Nonsense-Mediated Decay (NMD)	3.98	1.64e-04	0.010283	10/105	RPL15; RPS18; RPL39; RPLP2; RPS26; RPL6; RPLP1; RPS21; RPL18A; RPS9
R-HSA-975957	Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)	3.98	1.64e-04	0.010283	10/105	RPL15; RPS18; RPL39; RPLP2; RPS26; RPL6; RPLP1; RPS21; RPL18A; RPS9
R-HSA-72706	GTP hydrolysis and joining of the 60S ribosomal subunit	3.94	1.78e-04	0.010283	10/106	RPL15; RPS18; RPL39; RPLP2; RPS26; RPL6; RPLP1; RPS21; RPL18A; RPS9
R-HSA-1799339	SRP-dependent cotranslational protein targeting to membrane	3.94	1.78e-04	0.010283	10/106	RPL15; RPS18; RPL39; RPLP2; RPS26; RPL6; RPLP1; RPS21; RPL18A; RPS9
R-HSA-72613	Eukaryotic Translation Initiation	3.73	2.81e-04	0.014330	10/112	RPL15; RPS18; RPL39; RPLP2; RPS26; RPL6; RPLP1; RPS21; RPL18A; RPS9
R-HSA-72737	Cap-dependent Translation Initiation	3.73	2.81e-04	0.014330	10/112	RPL15; RPS18; RPL39; RPLP2; RPS26; RPL6; RPLP1; RPS21; RPL18A; RPS9
R-HSA-168273	Influenza Viral RNA Transcription and Replication	3.51	4.60e-04	0.021011	10/119	RPL15; RPS18; RPL39; RPLP2; RPS26; RPL6; RPLP1; RPS21; RPL18A; RPS9
R-HSA-168254	Influenza Infection	3.36	3.51e-04	0.016898	11/137	RPL15; RPS18; SLC25A6; RPL39; RPLP2; RPS26; RPL6; RPLP1; RPS21; RPL18A; RPS9
R-HSA-168255	Influenza Life Cycle	3.27	8.23e-04	0.035666	10/128	RPL15; RPS18; RPL39; RPLP2; RPS26; RPL6; RPLP1; RPS21; RPL18A; RPS9
R-HSA-1280215	Cytokine Signaling in Immune system	3.05	6.44e-07	0.000558	23/315	GBP4; PTPN7; STAT1; HAVCR2; SQSTM1; HLA-B; LTB; HLA-DRA; HLA-DQA1; IL2RG; CD44; BIRC3; NFKB2; CD27; PTPN6; LCP1; NFKBIA; HIF1A; MT2A; JUNB; IL27RA; RELB; ITGB2
R-HSA-449147	Signaling by Interleukins	2.59	1.25e-03	0.049234	13/210	PTPN7; STAT1; HAVCR2; SQSTM1; IL2RG; NFKB2; PTPN6; LCP1; NFKBIA; HIF1A; JUNB; IL27RA; ITGB2

Factor 16 : 17 significant Reactome pathways

GeneSet	description	enrichRatio	pValue	FDR	GeneRatio	geneSymbols
R-HSA-70263	Gluconeogenesis	49.90	1.36e-11	1.18e-08	7/12	ENO1; PGK1; PGAM1; GAPDH; TPI1; ALDOA; ALDOC
R-HSA-70171	Glycolysis	20.30	2.14e-10	9.29e-08	9/38	ENO1; PGK1; PFKP; PGAM1; GAPDH; TPI1; PKM; ALDOA; ALDOC
R-HSA-70326	Glucose metabolism	18.30	5.67e-10	1.64e-07	9/42	ENO1; PGK1; PFKP; PGAM1; GAPDH; TPI1; PKM; ALDOA; ALDOC
R-HSA-3928662	EPHB-mediated forward signaling	15.10	9.03e-04	4.61e-02	3/17	ACTB; CFL1; ACTG1
R-HSA-71387	Metabolism of carbohydrates	8.91	8.61e-08	1.87e-05	10/96	ENO1; RPS27A; PGK1; PFKP; PGAM1; GAPDH; TPI1; PKM; ALDOA; ALDOC
R-HSA-156842	Eukaryotic Translation Elongation	6.88	5.25e-05	9.10e-03	7/87	RPS27A; RPS18; EEF1D; RPS24; RPS15; RPL13A; RPL3
R-HSA-156902	Peptide chain elongation	6.11	3.67e-04	3.09e-02	6/84	RPS27A; RPS18; RPS24; RPS15; RPL13A; RPL3
R-HSA-192823	Viral mRNA Translation	6.11	3.67e-04	3.09e-02	6/84	RPS27A; RPS18; RPS24; RPS15; RPL13A; RPL3
R-HSA-2408522	Selenoamino acid metabolism	6.05	1.20e-04	1.41e-02	7/99	RPS27A; DARS; RPS18; RPS24; RPS15; RPL13A; RPL3
R-HSA-2408557	Selenocysteine synthesis	6.04	3.92e-04	3.09e-02	6/85	RPS27A; RPS18; RPS24; RPS15; RPL13A; RPL3
R-HSA-72764	Eukaryotic Translation Termination	5.90	4.45e-04	3.16e-02	6/87	RPS27A; RPS18; RPS24; RPS15; RPL13A; RPL3
R-HSA-975956	Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)	5.83	4.73e-04	3.16e-02	6/88	RPS27A; RPS18; RPS24; RPS15; RPL13A; RPL3
R-HSA-72689	Formation of a pool of free 40S subunits	5.40	7.14e-04	4.13e-02	6/95	RPS27A; RPS18; RPS24; RPS15; RPL13A; RPL3
R-HSA-168254	Influenza Infection	4.37	8.94e-04	4.61e-02	7/137	RPS27A; RPS18; SLC25A6; RPS24; RPS15; RPL13A; RPL3
R-HSA-376176	Signaling by ROBO receptors	4.10	5.67e-04	3.51e-02	8/167	RPS27A; RPS18; RPS24; TCEB2; PFN1; RPS15; RPL13A; RPL3
R-HSA-422475	Axon guidance	3.69	1.12e-04	1.41e-02	11/255	RPS27A; RPS18; ACTB; CFL1; RPS24; TCEB2; PFN1; ACTG1; RPS15; RPL13A; RPL3
R-HSA-1266738	Developmental Biology	3.12	1.30e-04	1.41e-02	13/356	H3F3A; RPS27A; HIST1H4C; RPS18; ACTB; CFL1; RPS24; TCEB2; PFN1; ACTG1; RPS15; RPL13A; RPL3

Factor 17 : 33 significant Reactome pathways

GeneSet	description	enrichRatio	pValue	FDR	GeneRatio	geneSymbols
R-HSA-72689	Formation of a pool of free 40S subunits	14.80	0.00000	0.00000	51/95	RPL11; RPS8; RPS27; RPL31; RPL37A; RPL32; RPSA; RPL14; RPL29; RPL35A; RPL9; RPL34; RPS3A; RPL37; RPS23; RPS18; RPS12; RPS4X; RPL36A; RPL39; RPL10; RPL30; EIF3E; EIF3H; RPL12; RPLP2; EIF3F; RPL27A; RPS13; EIF3M; RPS25; RPL41; RPL21; RPS29; RPS17; RPS2; RPS15A; RPL13; RPL26; RPL23A; RPL23; RPL27; RPL38; RPS28; EIF3G; RPL18A; EIF3K; RPS16; RPS9; RPL28; EIF3D
R-HSA-156902	Peptide chain elongation	14.80	0.00000	0.00000	45/84	RPL11; RPS8; RPS27; RPL31; RPL37A; RPL32; RPSA; RPL14; RPL29; RPL35A; RPL9; RPL34; RPS3A; RPL37; RPS23; RPS18; RPS12; RPS4X; RPL36A; RPL39; RPL10; RPL30; RPL12; RPLP2; RPL27A; RPS13; RPS25; RPL41; RPL21; RPS29; RPS17; RPS2; RPS15A; RPL13; RPL26; RPL23A; RPL23; RPL27; RPL38; EEF2; RPS28; RPL18A; RPS16; RPS9; RPL28
R-HSA-192823	Viral mRNA Translation	14.50	0.00000	0.00000	44/84	RPL11; RPS8; RPS27; RPL31; RPL37A; RPL32; RPSA; RPL14; RPL29; RPL35A; RPL9; RPL34; RPS3A; RPL37; RPS23; RPS18; RPS12; RPS4X; RPL36A; RPL39; RPL10; RPL30; RPL12; RPLP2; RPL27A; RPS13; RPS25; RPL41; RPL21; RPS29; RPS17; RPS2; RPS15A; RPL13; RPL26; RPL23A; RPL23; RPL27; RPL38; RPS28; RPL18A; RPS16; RPS9; RPL28
R-HSA-72695	Formation of the ternary complex, and subsequently, the 43S complex	14.40	0.00000	0.00000	25/48	RPS8; RPS27; RPSA; RPS3A; RPS23; RPS18; RPS12; EIF2S3; RPS4X; EIF3E; EIF3H; EIF3F; RPS13; EIF3M; RPS25; RPS29; RPS17; RPS2; RPS15A; RPS28; EIF3G; EIF3K; RPS16; RPS9; EIF3D
R-HSA-2408557	Selenocysteine synthesis	14.30	0.00000	0.00000	44/85	RPL11; RPS8; RPS27; RPL31; RPL37A; RPL32; RPSA; RPL14; RPL29; RPL35A; RPL9; RPL34; RPS3A; RPL37; RPS23; RPS18; RPS12; RPS4X; RPL36A; RPL39; RPL10; RPL30; RPL12; RPLP2; RPL27A; RPS13; RPS25; RPL41; RPL21; RPS29; RPS17; RPS2; RPS15A; RPL13; RPL26; RPL23A; RPL23; RPL27; RPL38; RPS28; RPL18A; RPS16; RPS9; RPL28
R-HSA-156842	Eukaryotic Translation Elongation	14.30	0.00000	0.00000	45/87	RPL11; RPS8; RPS27; RPL31; RPL37A; RPL32; RPSA; RPL14; RPL29; RPL35A; RPL9; RPL34; RPS3A; RPL37; RPS23; RPS18; RPS12; RPS4X; RPL36A; RPL39; RPL10; RPL30; RPL12; RPLP2; RPL27A; RPS13; RPS25; RPL41; RPL21; RPS29; RPS17; RPS2; RPS15A; RPL13; RPL26; RPL23A; RPL23; RPL27; RPL38; EEF2; RPS28; RPL18A; RPS16; RPS9; RPL28
R-HSA-975956	Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)	14.10	0.00000	0.00000	45/88	RPL11; RPS8; RPS27; RPL31; RPL37A; RPL32; RPSA; RPL14; RPL29; RPL35A; RPL9; RPL34; RPS3A; RPL37; RPS23; RPS18; RPS12; RPS4X; RPL36A; RPL39; RPL10; RPL30; PABPC1; RPL12; RPLP2; RPL27A; RPS13; RPS25; RPL41; RPL21; RPS29; RPS17; RPS2; RPS15A; RPL13; RPL26; RPL23A; RPL23; RPL27; RPL38; RPS28; RPL18A; RPS16; RPS9; RPL28
R-HSA-72764	Eukaryotic Translation Termination	14.00	0.00000	0.00000	44/87	RPL11; RPS8; RPS27; RPL31; RPL37A; RPL32; RPSA; RPL14; RPL29; RPL35A; RPL9; RPL34; RPS3A; RPL37; RPS23; RPS18; RPS12; RPS4X; RPL36A; RPL39; RPL10; RPL30; RPL12; RPLP2; RPL27A; RPS13; RPS25; RPL41; RPL21; RPS29; RPS17; RPS2; RPS15A; RPL13; RPL26; RPL23A; RPL23; RPL27; RPL38; RPS28; RPL18A; RPS16; RPS9; RPL28
R-HSA-156827	L13a-mediated translational silencing of Ceruloplasmin expression	14.00	0.00000	0.00000	53/105	RPL11; RPS8; RPS27; RPL31; RPL37A; RPL32; RPSA; RPL14; RPL29; RPL35A; RPL9; RPL34; RPS3A; RPL37; RPS23; RPS18; RPS12; EIF2S3; RPS4X; RPL36A; RPL39; RPL10; RPL30; PABPC1; EIF3E; EIF3H; RPL12; RPLP2; EIF3F; RPL27A; RPS13; EIF3M; RPS25; RPL41; RPL21; RPS29; RPS17; RPS2; RPS15A; RPL13; RPL26; RPL23A; RPL23; RPL27; RPL38; RPS28; EIF3G; RPL18A; EIF3K; RPS16; RPS9; RPL28; EIF3D
R-HSA-72706	GTP hydrolysis and joining of the 60S ribosomal subunit	13.60	0.00000	0.00000	52/106	RPL11; RPS8; RPS27; RPL31; RPL37A; RPL32; RPSA; RPL14; RPL29; RPL35A; RPL9; RPL34; RPS3A; RPL37; RPS23; RPS18; RPS12; EIF2S3; RPS4X; RPL36A; RPL39; RPL10; RPL30; EIF3E; EIF3H; RPL12; RPLP2; EIF3F; RPL27A; RPS13; EIF3M; RPS25; RPL41; RPL21; RPS29; RPS17; RPS2; RPS15A; RPL13; RPL26; RPL23A; RPL23; RPL27; RPL38; RPS28; EIF3G; RPL18A; EIF3K; RPS16; RPS9; RPL28; EIF3D
R-HSA-72613	Eukaryotic Translation Initiation	13.10	0.00000	0.00000	53/112	RPL11; RPS8; RPS27; RPL31; RPL37A; RPL32; RPSA; RPL14; RPL29; RPL35A; RPL9; RPL34; RPS3A; RPL37; RPS23; RPS18; RPS12; EIF2S3; RPS4X; RPL36A; RPL39; RPL10; RPL30; PABPC1; EIF3E; EIF3H; RPL12; RPLP2; EIF3F; RPL27A; RPS13; EIF3M; RPS25; RPL41; RPL21; RPS29; RPS17; RPS2; RPS15A; RPL13; RPL26; RPL23A; RPL23; RPL27; RPL38; RPS28; EIF3G; RPL18A; EIF3K; RPS16; RPS9; RPL28; EIF3D
R-HSA-72737	Cap-dependent Translation Initiation	13.10	0.00000	0.00000	53/112	RPL11; RPS8; RPS27; RPL31; RPL37A; RPL32; RPSA; RPL14; RPL29; RPL35A; RPL9; RPL34; RPS3A; RPL37; RPS23; RPS18; RPS12; EIF2S3; RPS4X; RPL36A; RPL39; RPL10; RPL30; PABPC1; EIF3E; EIF3H; RPL12; RPLP2; EIF3F; RPL27A; RPS13; EIF3M; RPS25; RPL41; RPL21; RPS29; RPS17; RPS2; RPS15A; RPL13; RPL26; RPL23A; RPL23; RPL27; RPL38; RPS28; EIF3G; RPL18A; EIF3K; RPS16; RPS9; RPL28; EIF3D
R-HSA-72649	Translation initiation complex formation	13.10	0.00000	0.00000	26/55	RPS8; RPS27; RPSA; RPS3A; RPS23; RPS18; RPS12; EIF2S3; RPS4X; PABPC1; EIF3E; EIF3H; EIF3F; RPS13; EIF3M; RPS25; RPS29; RPS17; RPS2; RPS15A; RPS28; EIF3G; EIF3K; RPS16; RPS9; EIF3D
R-HSA-72662	Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S	12.80	0.00000	0.00000	26/56	RPS8; RPS27; RPSA; RPS3A; RPS23; RPS18; RPS12; EIF2S3; RPS4X; PABPC1; EIF3E; EIF3H; EIF3F; RPS13; EIF3M; RPS25; RPS29; RPS17; RPS2; RPS15A; RPS28; EIF3G; EIF3K; RPS16; RPS9; EIF3D
R-HSA-72702	Ribosomal scanning and start codon recognition	12.60	0.00000	0.00000	25/55	RPS8; RPS27; RPSA; RPS3A; RPS23; RPS18; RPS12; EIF2S3; RPS4X; EIF3E; EIF3H; EIF3F; RPS13; EIF3M; RPS25; RPS29; RPS17; RPS2; RPS15A; RPS28; EIF3G; EIF3K; RPS16; RPS9; EIF3D
R-HSA-2408522	Selenoamino acid metabolism	12.30	0.00000	0.00000	44/99	RPL11; RPS8; RPS27; RPL31; RPL37A; RPL32; RPSA; RPL14; RPL29; RPL35A; RPL9; RPL34; RPS3A; RPL37; RPS23; RPS18; RPS12; RPS4X; RPL36A; RPL39; RPL10; RPL30; RPL12; RPLP2; RPL27A; RPS13; RPS25; RPL41; RPL21; RPS29; RPS17; RPS2; RPS15A; RPL13; RPL26; RPL23A; RPL23; RPL27; RPL38; RPS28; RPL18A; RPS16; RPS9; RPL28
R-HSA-927802	Nonsense-Mediated Decay (NMD)	11.90	0.00000	0.00000	45/105	RPL11; RPS8; RPS27; RPL31; RPL37A; RPL32; RPSA; RPL14; RPL29; RPL35A; RPL9; RPL34; RPS3A; RPL37; RPS23; RPS18; RPS12; RPS4X; RPL36A; RPL39; RPL10; RPL30; PABPC1; RPL12; RPLP2; RPL27A; RPS13; RPS25; RPL41; RPL21; RPS29; RPS17; RPS2; RPS15A; RPL13; RPL26; RPL23A; RPL23; RPL27; RPL38; RPS28; RPL18A; RPS16; RPS9; RPL28
R-HSA-975957	Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)	11.90	0.00000	0.00000	45/105	RPL11; RPS8; RPS27; RPL31; RPL37A; RPL32; RPSA; RPL14; RPL29; RPL35A; RPL9; RPL34; RPS3A; RPL37; RPS23; RPS18; RPS12; RPS4X; RPL36A; RPL39; RPL10; RPL30; PABPC1; RPL12; RPLP2; RPL27A; RPS13; RPS25; RPL41; RPL21; RPS29; RPS17; RPS2; RPS15A; RPL13; RPL26; RPL23A; RPL23; RPL27; RPL38; RPS28; RPL18A; RPS16; RPS9; RPL28
R-HSA-1799339	SRP-dependent cotranslational protein targeting to membrane	11.70	0.00000	0.00000	45/106	RPL11; RPS8; RPS27; SSR2; RPL31; RPL37A; RPL32; RPSA; RPL14; RPL29; RPL35A; RPL9; RPL34; RPS3A; RPL37; RPS23; RPS18; RPS12; RPS4X; RPL36A; RPL39; RPL10; RPL30; RPL12; RPLP2; RPL27A; RPS13; RPS25; RPL41; RPL21; RPS29; RPS17; RPS2; RPS15A; RPL13; RPL26; RPL23A; RPL23; RPL27; RPL38; RPS28; RPL18A; RPS16; RPS9; RPL28
R-HSA-168273	Influenza Viral RNA Transcription and Replication	10.50	0.00000	0.00000	45/119	RPL11; RPS8; RPS27; RPL31; RPL37A; RPL32; RPSA; RPL14; RPL29; RPL35A; RPL9; RPL34; RPS3A; RPL37; RPS23; RPS18; RPS12; RPS4X; RPL36A; RPL39; RPL10; RPL30; RPL12; RPLP2; RPL27A; RPS13; RPS25; RPL41; RPL21; RPS29; RPS17; RPS2; RPS15A; RPL13; RPL26; RPL23A; RPL23; RPL27; RPL38; GTF2F1; RPS28; RPL18A; RPS16; RPS9; RPL28
R-HSA-168255	Influenza Life Cycle	9.72	0.00000	0.00000	45/128	RPL11; RPS8; RPS27; RPL31; RPL37A; RPL32; RPSA; RPL14; RPL29; RPL35A; RPL9; RPL34; RPS3A; RPL37; RPS23; RPS18; RPS12; RPS4X; RPL36A; RPL39; RPL10; RPL30; RPL12; RPLP2; RPL27A; RPS13; RPS25; RPL41; RPL21; RPS29; RPS17; RPS2; RPS15A; RPL13; RPL26; RPL23A; RPL23; RPL27; RPL38; GTF2F1; RPS28; RPL18A; RPS16; RPS9; RPL28
R-HSA-168254	Influenza Infection	9.29	0.00000	0.00000	46/137	RPL11; RPS8; RPS27; RPL31; RPL37A; RPL32; RPSA; RPL14; RPL29; RPL35A; RPL9; RPL34; RPS3A; RPL37; RPS23; RPS18; RPS12; SLC25A6; RPS4X; RPL36A; RPL39; RPL10; RPL30; RPL12; RPLP2; RPL27A; RPS13; RPS25; RPL41; RPL21; RPS29; RPS17; RPS2; RPS15A; RPL13; RPL26; RPL23A; RPL23; RPL27; RPL38; GTF2F1; RPS28; RPL18A; RPS16; RPS9; RPL28
R-HSA-9010553	Regulation of expression of SLITs and ROBOs	8.47	0.00000	0.00000	45/147	RPL11; RPS8; RPS27; RPL31; RPL37A; RPL32; RPSA; RPL14; RPL29; RPL35A; RPL9; RPL34; RPS3A; RPL37; RPS23; RPS18; RPS12; RPS4X; RPL36A; RPL39; RPL10; RPL30; PABPC1; RPL12; RPLP2; RPL27A; RPS13; RPS25; RPL41; RPL21; RPS29; RPS17; RPS2; RPS15A; RPL13; RPL26; RPL23A; RPL23; RPL27; RPL38; RPS28; RPL18A; RPS16; RPS9; RPL28
R-HSA-6791226	Major pathway of rRNA processing in the nucleolus and cytosol	8.24	0.00000	0.00000	45/151	RPL11; RPS8; RPS27; RPL31; RPL37A; RPL32; RPSA; RPL14; RPL29; RPL35A; RPL9; RPL34; RPS3A; RPL37; RPS23; RPS18; RPS12; RPS4X; RPL36A; RPL39; RPL10; RPL30; RPL12; RPLP2; RPL27A; RPS13; RPS25; RPL41; RPL21; RPS29; RPS17; RPS2; RPS15A; NOB1; RPL13; RPL26; RPL23A; RPL23; RPL27; RPL38; RPS28; RPL18A; RPS16; RPS9; RPL28
R-HSA-163210	Formation of ATP by chemiosmotic coupling	8.13	0.00025	0.00657	5/17	ATP5F1; ATP5L; ATP5G2; ATP5B; ATP5D
R-HSA-8868773	rRNA processing in the nucleus and cytosol	7.78	0.00000	0.00000	45/160	RPL11; RPS8; RPS27; RPL31; RPL37A; RPL32; RPSA; RPL14; RPL29; RPL35A; RPL9; RPL34; RPS3A; RPL37; RPS23; RPS18; RPS12; RPS4X; RPL36A; RPL39; RPL10; RPL30; RPL12; RPLP2; RPL27A; RPS13; RPS25; RPL41; RPL21; RPS29; RPS17; RPS2; RPS15A; NOB1; RPL13; RPL26; RPL23A; RPL23; RPL27; RPL38; RPS28; RPL18A; RPS16; RPS9; RPL28
R-HSA-72312	rRNA processing	7.50	0.00000	0.00000	45/166	RPL11; RPS8; RPS27; RPL31; RPL37A; RPL32; RPSA; RPL14; RPL29; RPL35A; RPL9; RPL34; RPS3A; RPL37; RPS23; RPS18; RPS12; RPS4X; RPL36A; RPL39; RPL10; RPL30; RPL12; RPLP2; RPL27A; RPS13; RPS25; RPL41; RPL21; RPS29; RPS17; RPS2; RPS15A; NOB1; RPL13; RPL26; RPL23A; RPL23; RPL27; RPL38; RPS28; RPL18A; RPS16; RPS9; RPL28
R-HSA-376176	Signaling by ROBO receptors	7.45	0.00000	0.00000	45/167	RPL11; RPS8; RPS27; RPL31; RPL37A; RPL32; RPSA; RPL14; RPL29; RPL35A; RPL9; RPL34; RPS3A; RPL37; RPS23; RPS18; RPS12; RPS4X; RPL36A; RPL39; RPL10; RPL30; PABPC1; RPL12; RPLP2; RPL27A; RPS13; RPS25; RPL41; RPL21; RPS29; RPS17; RPS2; RPS15A; RPL13; RPL26; RPL23A; RPL23; RPL27; RPL38; RPS28; RPL18A; RPS16; RPS9; RPL28
R-HSA-71291	Metabolism of amino acids and derivatives	6.40	0.00000	0.00000	47/203	RPL11; RPS8; CCBL2; RPS27; RPL31; RPL37A; RPL32; RPSA; RPL14; RPL29; RPL35A; RPL9; RPL34; RPS3A; RPL37; RPS23; RPS18; RPS12; RPS4X; RPL36A; RPL39; RPL10; RPL30; RPL12; RPLP2; RPL27A; RPS13; RPS25; PCBD1; RPL41; RPL21; RPS29; RPS17; RPS2; RPS15A; RPL13; RPL26; RPL23A; RPL23; RPL27; RPL38; RPS28; RPL18A; RPS16; ETHE1; RPS9; RPL28
R-HSA-72766	Translation	6.35	0.00000	0.00000	59/257	RPL11; RPS8; MRPS21; RPS27; SSR2; RPL31; RPL37A; RPL32; RPSA; RPL14; RPL29; RPL35A; RPL9; RPL34; RPS3A; RPL37; RPS23; RPS18; RPS12; EIF2S3; RPS4X; RPL36A; RPL39; RPL10; RPL30; PABPC1; EIF3E; EIF3H; RPL12; RPLP2; CARS; EIF3F; RPL27A; RPS13; EIF3M; RPS25; RPL41; RPL21; OXA1L; RPS29; RPS17; RPS2; RPS15A; RPL13; RPL26; RPL23A; RPL23; RPL27; MRPL10; RPL38; EEF2; RPS28; EIF3G; RPL18A; EIF3K; RPS16; RPS9; RPL28; EIF3D
R-HSA-422475	Axon guidance	5.53	0.00000	0.00000	51/255	RPL11; RPS8; RPS27; RPL31; RPL37A; RPL32; RPSA; RPL14; RPL29; RPL35A; RPL9; RPL34; RPS3A; RPL37; RPS23; CSNK2B; RPS18; HSP90AB1; RPS12; ACTB; RPS4X; RPL36A; RPL39; RPL10; RPL30; PABPC1; RPL12; RPLP2; RPL27A; RPS13; RPS25; HSPA8; ITGB1; RPL41; RPL21; RPS29; RPS17; RPS2; RPS15A; RPL13; RPL26; RPL23A; RPL23; RPL27; RPL38; ACTG1; RPS28; RPL18A; RPS16; RPS9; RPL28
R-HSA-5663205	Infectious disease	4.84	0.00000	0.00000	52/297	RPL11; RPS8; RPS27; RPL31; RPL37A; RPL32; RPSA; RPL14; RPL29; RPL35A; RPL9; RPL34; RPS3A; RPL37; RPS23; NPM1; RPS18; HMGA1; HSP90AB1; RPS12; SLC25A6; RPS4X; RPL36A; SLC25A5; RPL39; RPL10; RPL30; RPL12; RPLP2; RPL27A; RPS13; RPS25; RPL41; RPL21; RPS29; B2M; RPS17; RPS2; RPS15A; RPL13; RPL26; RPL23A; RPL23; RPL27; RPL38; EEF2; GTF2F1; RPS28; RPL18A; RPS16; RPS9; RPL28
R-HSA-1266738	Developmental Biology	3.96	0.00000	0.00000	51/356	RPL11; RPS8; RPS27; RPL31; RPL37A; RPL32; RPSA; RPL14; RPL29; RPL35A; RPL9; RPL34; RPS3A; RPL37; RPS23; CSNK2B; RPS18; HSP90AB1; RPS12; ACTB; RPS4X; RPL36A; RPL39; RPL10; RPL30; PABPC1; RPL12; RPLP2; RPL27A; RPS13; RPS25; HSPA8; ITGB1; RPL41; RPL21; RPS29; RPS17; RPS2; RPS15A; RPL13; RPL26; RPL23A; RPL23; RPL27; RPL38; ACTG1; RPS28; RPL18A; RPS16; RPS9; RPL28

Factor 19 : 16 significant Reactome pathways

GeneSet	description	enrichRatio	pValue	FDR	GeneRatio	geneSymbols
R-HSA-202430	Translocation of ZAP-70 to Immunological synapse	87.60	2.17e-13	9.41e-11	7/14	HLA-DRA; HLA-DRB5; HLA-DRB1; HLA-DQA1; HLA-DQB1; HLA-DPA1; HLA-DPB1
R-HSA-389948	PD-1 signaling	81.70	4.06e-13	1.17e-10	7/15	HLA-DRA; HLA-DRB5; HLA-DRB1; HLA-DQA1; HLA-DQB1; HLA-DPA1; HLA-DPB1
R-HSA-202427	Phosphorylation of CD3 and TCR zeta chains	72.10	1.22e-12	2.64e-10	7/17	HLA-DRA; HLA-DRB5; HLA-DRB1; HLA-DQA1; HLA-DQB1; HLA-DPA1; HLA-DPB1
R-HSA-202433	Generation of second messenger molecules	53.30	1.50e-11	2.55e-09	7/23	HLA-DRA; HLA-DRB5; HLA-DRB1; HLA-DQA1; HLA-DQB1; HLA-DPA1; HLA-DPB1
R-HSA-877300	Interferon gamma signaling	39.80	6.44e-15	5.58e-12	10/44	HLA-A; HLA-C; HLA-B; HLA-DRA; HLA-DRB5; HLA-DRB1; HLA-DQA1; HLA-DQB1; HLA-DPA1; HLA-DPB1
R-HSA-388841	Costimulation by the CD28 family	30.60	1.08e-09	1.17e-07	7/40	HLA-DRA; HLA-DRB5; HLA-DRB1; HLA-DQA1; HLA-DQB1; HLA-DPA1; HLA-DPB1
R-HSA-983170	Antigen Presentation: Folding, assembly and peptide loading of class I MHC	26.30	1.72e-04	1.06e-02	3/20	HLA-A; HLA-C; HLA-B
R-HSA-2132295	MHC class II antigen presentation	25.00	1.76e-11	2.55e-09	9/63	CD74; HLA-DRA; HLA-DRB5; HLA-DRB1; HLA-DQA1; HLA-DQB1; HLA-DMB; HLA-DPA1; HLA-DPB1
R-HSA-909733	Interferon alpha/beta signaling	16.40	7.16e-04	3.88e-02	3/32	HLA-A; HLA-C; HLA-B
R-HSA-913531	Interferon Signaling	16.40	7.69e-11	9.52e-09	10/107	HLA-A; HLA-C; HLA-B; HLA-DRA; HLA-DRB5; HLA-DRB1; HLA-DQA1; HLA-DQB1; HLA-DPA1; HLA-DPB1
R-HSA-198933	Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell	16.30	8.39e-05	5.60e-03	4/43	HLA-A; HLA-C; HLA-B; KLRD1
R-HSA-202424	Downstream TCR signaling	14.80	2.08e-07	1.64e-05	7/83	HLA-DRA; HLA-DRB5; HLA-DRB1; HLA-DQA1; HLA-DQB1; HLA-DPA1; HLA-DPB1
R-HSA-202403	TCR signaling	12.40	7.07e-07	5.11e-05	7/99	HLA-DRA; HLA-DRB5; HLA-DRB1; HLA-DQA1; HLA-DQB1; HLA-DPA1; HLA-DPB1
R-HSA-418594	G alpha (i) signalling events	10.50	4.77e-04	2.76e-02	4/67	RGS1; CCL4; CCL4L2
R-HSA-1280215	Cytokine Signaling in Immune system	6.67	1.85e-08	1.78e-06	12/315	HLA-A; HLA-C; HLA-B; HLA-DRA; HLA-DRB5; HLA-DRB1; HLA-DQA1; HLA-DQB1; HLA-DPA1; HLA-DPB1; CCL4; CCL4L2
R-HSA-1280218	Adaptive Immune System	5.62	2.60e-08	2.25e-06	13/405	CD74; HLA-A; HLA-C; HLA-B; HLA-DRA; HLA-DRB5; HLA-DRB1; HLA-DQA1; HLA-DQB1; HLA-DMB; HLA-DPA1; HLA-DPB1; KLRD1

Factor 20 : 33 significant Reactome pathways

GeneSet	description	enrichRatio	pValue	FDR	GeneRatio	geneSymbols
R-HSA-156902	Peptide chain elongation	21.90	0.00e+00	0.00e+00	33/84	RPS8; RPS27; RPL31; RPL15; RPL14; RPL35A; RPL34; RPS3A; RPS14; EEF1A1; RPS4X; RPL10; RPL30; RPS6; RPL12; RPL27A; RPS25; RPS24; RPS26; RPL41; RPLP0; RPS29; RPL36AL; RPL4; RPLP1; RPL23A; RPL38; RPS21; RPS15; EEF2; RPL36; RPS28; RPL28
R-HSA-156842	Eukaryotic Translation Elongation	21.80	0.00e+00	0.00e+00	34/87	RPS8; RPS27; RPL31; EEF1B2; RPL15; RPL14; RPL35A; RPL34; RPS3A; RPS14; EEF1A1; RPS4X; RPL10; RPL30; RPS6; RPL12; RPL27A; RPS25; RPS24; RPS26; RPL41; RPLP0; RPS29; RPL36AL; RPL4; RPLP1; RPL23A; RPL38; RPS21; RPS15; EEF2; RPL36; RPS28; RPL28
R-HSA-192823	Viral mRNA Translation	20.60	0.00e+00	0.00e+00	31/84	RPS8; RPS27; RPL31; RPL15; RPL14; RPL35A; RPL34; RPS3A; RPS14; RPS4X; RPL10; RPL30; RPS6; RPL12; RPL27A; RPS25; RPS24; RPS26; RPL41; RPLP0; RPS29; RPL36AL; RPL4; RPLP1; RPL23A; RPL38; RPS21; RPS15; RPL36; RPS28; RPL28
R-HSA-2408557	Selenocysteine synthesis	20.30	0.00e+00	0.00e+00	31/85	RPS8; RPS27; RPL31; RPL15; RPL14; RPL35A; RPL34; RPS3A; RPS14; RPS4X; RPL10; RPL30; RPS6; RPL12; RPL27A; RPS25; RPS24; RPS26; RPL41; RPLP0; RPS29; RPL36AL; RPL4; RPLP1; RPL23A; RPL38; RPS21; RPS15; RPL36; RPS28; RPL28
R-HSA-975956	Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)	20.30	0.00e+00	0.00e+00	32/88	RPS8; RPS27; RPL31; RPL15; RPL14; RPL35A; RPL34; RPS3A; RPS14; RPS4X; RPL10; RPL30; PABPC1; RPS6; RPL12; RPL27A; RPS25; RPS24; RPS26; RPL41; RPLP0; RPS29; RPL36AL; RPL4; RPLP1; RPL23A; RPL38; RPS21; RPS15; RPL36; RPS28; RPL28
R-HSA-72764	Eukaryotic Translation Termination	19.90	0.00e+00	0.00e+00	31/87	RPS8; RPS27; RPL31; RPL15; RPL14; RPL35A; RPL34; RPS3A; RPS14; RPS4X; RPL10; RPL30; RPS6; RPL12; RPL27A; RPS25; RPS24; RPS26; RPL41; RPLP0; RPS29; RPL36AL; RPL4; RPLP1; RPL23A; RPL38; RPS21; RPS15; RPL36; RPS28; RPL28
R-HSA-72689	Formation of a pool of free 40S subunits	18.20	0.00e+00	0.00e+00	31/95	RPS8; RPS27; RPL31; RPL15; RPL14; RPL35A; RPL34; RPS3A; RPS14; RPS4X; RPL10; RPL30; RPS6; RPL12; RPL27A; RPS25; RPS24; RPS26; RPL41; RPLP0; RPS29; RPL36AL; RPL4; RPLP1; RPL23A; RPL38; RPS21; RPS15; RPL36; RPS28; RPL28
R-HSA-2408522	Selenoamino acid metabolism	17.40	0.00e+00	0.00e+00	31/99	RPS8; RPS27; RPL31; RPL15; RPL14; RPL35A; RPL34; RPS3A; RPS14; RPS4X; RPL10; RPL30; RPS6; RPL12; RPL27A; RPS25; RPS24; RPS26; RPL41; RPLP0; RPS29; RPL36AL; RPL4; RPLP1; RPL23A; RPL38; RPS21; RPS15; RPL36; RPS28; RPL28
R-HSA-156827	L13a-mediated translational silencing of Ceruloplasmin expression	17.00	0.00e+00	0.00e+00	32/105	RPS8; RPS27; RPL31; RPL15; RPL14; RPL35A; RPL34; RPS3A; RPS14; RPS4X; RPL10; RPL30; PABPC1; RPS6; RPL12; RPL27A; RPS25; RPS24; RPS26; RPL41; RPLP0; RPS29; RPL36AL; RPL4; RPLP1; RPL23A; RPL38; RPS21; RPS15; RPL36; RPS28; RPL28
R-HSA-927802	Nonsense-Mediated Decay (NMD)	17.00	0.00e+00	0.00e+00	32/105	RPS8; RPS27; RPL31; RPL15; RPL14; RPL35A; RPL34; RPS3A; RPS14; RPS4X; RPL10; RPL30; PABPC1; RPS6; RPL12; RPL27A; RPS25; RPS24; RPS26; RPL41; RPLP0; RPS29; RPL36AL; RPL4; RPLP1; RPL23A; RPL38; RPS21; RPS15; RPL36; RPS28; RPL28
R-HSA-975957	Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)	17.00	0.00e+00	0.00e+00	32/105	RPS8; RPS27; RPL31; RPL15; RPL14; RPL35A; RPL34; RPS3A; RPS14; RPS4X; RPL10; RPL30; PABPC1; RPS6; RPL12; RPL27A; RPS25; RPS24; RPS26; RPL41; RPLP0; RPS29; RPL36AL; RPL4; RPLP1; RPL23A; RPL38; RPS21; RPS15; RPL36; RPS28; RPL28
R-HSA-72706	GTP hydrolysis and joining of the 60S ribosomal subunit	16.30	0.00e+00	0.00e+00	31/106	RPS8; RPS27; RPL31; RPL15; RPL14; RPL35A; RPL34; RPS3A; RPS14; RPS4X; RPL10; RPL30; RPS6; RPL12; RPL27A; RPS25; RPS24; RPS26; RPL41; RPLP0; RPS29; RPL36AL; RPL4; RPLP1; RPL23A; RPL38; RPS21; RPS15; RPL36; RPS28; RPL28
R-HSA-1799339	SRP-dependent cotranslational protein targeting to membrane	16.30	0.00e+00	0.00e+00	31/106	RPS8; RPS27; RPL31; RPL15; RPL14; RPL35A; RPL34; RPS3A; RPS14; RPS4X; RPL10; RPL30; RPS6; RPL12; RPL27A; RPS25; RPS24; RPS26; RPL41; RPLP0; RPS29; RPL36AL; RPL4; RPLP1; RPL23A; RPL38; RPS21; RPS15; RPL36; RPS28; RPL28
R-HSA-72613	Eukaryotic Translation Initiation	15.90	0.00e+00	0.00e+00	32/112	RPS8; RPS27; RPL31; RPL15; RPL14; RPL35A; RPL34; RPS3A; RPS14; RPS4X; RPL10; RPL30; PABPC1; RPS6; RPL12; RPL27A; RPS25; RPS24; RPS26; RPL41; RPLP0; RPS29; RPL36AL; RPL4; RPLP1; RPL23A; RPL38; RPS21; RPS15; RPL36; RPS28; RPL28
R-HSA-72737	Cap-dependent Translation Initiation	15.90	0.00e+00	0.00e+00	32/112	RPS8; RPS27; RPL31; RPL15; RPL14; RPL35A; RPL34; RPS3A; RPS14; RPS4X; RPL10; RPL30; PABPC1; RPS6; RPL12; RPL27A; RPS25; RPS24; RPS26; RPL41; RPLP0; RPS29; RPL36AL; RPL4; RPLP1; RPL23A; RPL38; RPS21; RPS15; RPL36; RPS28; RPL28
R-HSA-72695	Formation of the ternary complex, and subsequently, the 43S complex	15.10	6.93e-13	1.94e-11	13/48	RPS8; RPS27; RPS3A; RPS14; RPS4X; RPS6; RPS25; RPS24; RPS26; RPS29; RPS21; RPS15; RPS28
R-HSA-168273	Influenza Viral RNA Transcription and Replication	14.50	0.00e+00	0.00e+00	31/119	RPS8; RPS27; RPL31; RPL15; RPL14; RPL35A; RPL34; RPS3A; RPS14; RPS4X; RPL10; RPL30; RPS6; RPL12; RPL27A; RPS25; RPS24; RPS26; RPL41; RPLP0; RPS29; RPL36AL; RPL4; RPLP1; RPL23A; RPL38; RPS21; RPS15; RPL36; RPS28; RPL28
R-HSA-72649	Translation initiation complex formation	14.20	2.10e-13	6.27e-12	14/55	RPS8; RPS27; RPS3A; RPS14; RPS4X; PABPC1; RPS6; RPS25; RPS24; RPS26; RPS29; RPS21; RPS15; RPS28
R-HSA-72662	Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S	13.90	2.76e-13	7.98e-12	14/56	RPS8; RPS27; RPS3A; RPS14; RPS4X; PABPC1; RPS6; RPS25; RPS24; RPS26; RPS29; RPS21; RPS15; RPS28
R-HSA-168255	Influenza Life Cycle	13.50	0.00e+00	0.00e+00	31/128	RPS8; RPS27; RPL31; RPL15; RPL14; RPL35A; RPL34; RPS3A; RPS14; RPS4X; RPL10; RPL30; RPS6; RPL12; RPL27A; RPS25; RPS24; RPS26; RPL41; RPLP0; RPS29; RPL36AL; RPL4; RPLP1; RPL23A; RPL38; RPS21; RPS15; RPL36; RPS28; RPL28
R-HSA-72702	Ribosomal scanning and start codon recognition	13.20	4.74e-12	1.28e-10	13/55	RPS8; RPS27; RPS3A; RPS14; RPS4X; RPS6; RPS25; RPS24; RPS26; RPS29; RPS21; RPS15; RPS28
R-HSA-6783783	Interleukin-10 signaling	12.90	1.39e-03	3.65e-02	3/13	CCL3L3; CCL4L2
R-HSA-168254	Influenza Infection	12.60	0.00e+00	0.00e+00	31/137	RPS8; RPS27; RPL31; RPL15; RPL14; RPL35A; RPL34; RPS3A; RPS14; RPS4X; RPL10; RPL30; RPS6; RPL12; RPL27A; RPS25; RPS24; RPS26; RPL41; RPLP0; RPS29; RPL36AL; RPL4; RPLP1; RPL23A; RPL38; RPS21; RPS15; RPL36; RPS28; RPL28
R-HSA-9010553	Regulation of expression of SLITs and ROBOs	12.10	0.00e+00	0.00e+00	32/147	RPS8; RPS27; RPL31; RPL15; RPL14; RPL35A; RPL34; RPS3A; RPS14; RPS4X; RPL10; RPL30; PABPC1; RPS6; RPL12; RPL27A; RPS25; RPS24; RPS26; RPL41; RPLP0; RPS29; RPL36AL; RPL4; RPLP1; RPL23A; RPL38; RPS21; RPS15; RPL36; RPS28; RPL28
R-HSA-6791226	Major pathway of rRNA processing in the nucleolus and cytosol	11.40	0.00e+00	0.00e+00	31/151	RPS8; RPS27; RPL31; RPL15; RPL14; RPL35A; RPL34; RPS3A; RPS14; RPS4X; RPL10; RPL30; RPS6; RPL12; RPL27A; RPS25; RPS24; RPS26; RPL41; RPLP0; RPS29; RPL36AL; RPL4; RPLP1; RPL23A; RPL38; RPS21; RPS15; RPL36; RPS28; RPL28
R-HSA-8868773	rRNA processing in the nucleus and cytosol	10.80	0.00e+00	0.00e+00	31/160	RPS8; RPS27; RPL31; RPL15; RPL14; RPL35A; RPL34; RPS3A; RPS14; RPS4X; RPL10; RPL30; RPS6; RPL12; RPL27A; RPS25; RPS24; RPS26; RPL41; RPLP0; RPS29; RPL36AL; RPL4; RPLP1; RPL23A; RPL38; RPS21; RPS15; RPL36; RPS28; RPL28
R-HSA-376176	Signaling by ROBO receptors	10.70	0.00e+00	0.00e+00	32/167	RPS8; RPS27; RPL31; RPL15; RPL14; RPL35A; RPL34; RPS3A; RPS14; RPS4X; RPL10; RPL30; PABPC1; RPS6; RPL12; RPL27A; RPS25; RPS24; RPS26; RPL41; RPLP0; RPS29; RPL36AL; RPL4; RPLP1; RPL23A; RPL38; RPS21; RPS15; RPL36; RPS28; RPL28
R-HSA-72312	rRNA processing	10.40	0.00e+00	0.00e+00	31/166	RPS8; RPS27; RPL31; RPL15; RPL14; RPL35A; RPL34; RPS3A; RPS14; RPS4X; RPL10; RPL30; RPS6; RPL12; RPL27A; RPS25; RPS24; RPS26; RPL41; RPLP0; RPS29; RPL36AL; RPL4; RPLP1; RPL23A; RPL38; RPS21; RPS15; RPL36; RPS28; RPL28
R-HSA-71291	Metabolism of amino acids and derivatives	8.51	0.00e+00	0.00e+00	31/203	RPS8; RPS27; RPL31; RPL15; RPL14; RPL35A; RPL34; RPS3A; RPS14; RPS4X; RPL10; RPL30; RPS6; RPL12; RPL27A; RPS25; RPS24; RPS26; RPL41; RPLP0; RPS29; RPL36AL; RPL4; RPLP1; RPL23A; RPL38; RPS21; RPS15; RPL36; RPS28; RPL28
R-HSA-72766	Translation	7.59	0.00e+00	0.00e+00	35/257	RPS8; RPS27; RPL31; EEF1B2; RPL15; RPL14; RPL35A; RPL34; RPS3A; RPS14; EEF1A1; RPS4X; RPL10; RPL30; PABPC1; RPS6; RPL12; RPL27A; RPS25; RPS24; RPS26; RPL41; RPLP0; RPS29; RPL36AL; RPL4; RPLP1; RPL23A; RPL38; RPS21; RPS15; EEF2; RPL36; RPS28; RPL28
R-HSA-422475	Axon guidance	7.21	0.00e+00	0.00e+00	33/255	RPS8; RPS27; RPL31; RPL15; RPL14; RPL35A; RPL34; RPS3A; RPS14; RPS4X; RPL10; RPL30; PABPC1; RPS6; RPL12; RPL27A; RPS25; ITGB1; RPS24; RPS26; RPL41; RPLP0; RPS29; RPL36AL; RPL4; RPLP1; RPL23A; RPL38; RPS21; RPS15; RPL36; RPS28; RPL28
R-HSA-5663205	Infectious disease	6.00	0.00e+00	0.00e+00	32/297	RPS8; RPS27; RPL31; RPL15; RPL14; RPL35A; RPL34; RPS3A; RPS14; RPS4X; RPL10; RPL30; RPS6; RPL12; RPL27A; RPS25; RPS24; RPS26; RPL41; RPLP0; RPS29; RPL36AL; RPL4; RPLP1; RPL23A; RPL38; RPS21; RPS15; EEF2; RPL36; RPS28; RPL28
R-HSA-1266738	Developmental Biology	5.17	0.00e+00	0.00e+00	33/356	RPS8; RPS27; RPL31; RPL15; RPL14; RPL35A; RPL34; RPS3A; RPS14; RPS4X; RPL10; RPL30; PABPC1; RPS6; RPL12; RPL27A; RPS25; ITGB1; RPS24; RPS26; RPL41; RPLP0; RPS29; RPL36AL; RPL4; RPLP1; RPL23A; RPL38; RPS21; RPS15; RPL36; RPS28; RPL28

Summary:
Factor	1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	19	20
Signif_GO_terms	54	136	46	10	40	43	100	45	42	38	38	53	23	22	0	17	33	0	16	33

4 Gene Set Enrichment Analysis by Perturbation

Target genes: Genes w/ LFSR < 0.05 under each perturbation marker gene;
Backgroud genes: all 6000 genes used in factor analysis;
Statistical test: hypergeometric test (over-representation test);
Only GO terms/pathways that satisfy fold change \(\geq\) 2 and test FDR \(<\) 0.05 are shown below.

4.1 GO Slim Over-Representation Analysis

Gene sets: Gene ontology "Biological Process" (non-redundant).

CDKN1B : 55 significant GO terms

GeneSet	description	enrichRatio	pValue	FDR	GeneRatio	geneSymbols
GO:0050918	positive chemotaxis	7.22	3.50e-04	8.23e-03	5/12	HMGB2; HMGB1; CORO1A; CCL5; MIF
GO:0051383	kinetochore organization	7.22	3.50e-04	8.23e-03	5/12	CENPF; SMC4; SMC2; STRA13; NDC80
GO:0051131	chaperone-mediated protein complex assembly	6.30	2.60e-03	3.57e-02	4/11	HSPD1; HSP90AB1; PTGES3; HSP90AA1
GO:0070972	protein localization to endoplasmic reticulum	5.40	0.00e+00	0.00e+00	38/122	RPL11; RPS27; SRP9; RPS27A; RPL31; RPL14; RPL24; RPL35A; RPL9; RPL34; RPL37; RPS14; RPS10; RPS4X; RPL39; RPL10; RPL30; RPLP2; RPL27A; RPS3; RPS25; RPL21; RPS29; RPLP1; RPS15A; RPL13; RPL26; RPL23A; RPL23; RPL27; RPL38; RPL36; RPS28; UBA52; RPS19; RPL18; RPL13A; RPS11
GO:0070671	response to interleukin-12	4.95	1.77e-05	8.61e-04	10/35	HNRNPDL; LMNB1; HNRNPA2B1; PPIA; CFL1; LCP1; PSME2; ANXA2; SNRPA1; MIF
GO:0042769	DNA damage response, detection of DNA damage	4.95	1.26e-04	4.15e-03	8/28	USP1; RPS27A; RPA3; POLD2; RFC2; RPS3; PCNA; UBA52
GO:0036297	interstrand cross-link repair	4.72	1.19e-03	2.04e-02	6/22	NUCKS1; MSH6; RPS27A; RPA3; STRA13; UBA52
GO:0009262	deoxyribonucleotide metabolic process	4.52	1.54e-03	2.54e-02	6/23	DTYMK; NUDT1; RRM1; DUT; DCTPP1; TYMS
GO:0006413	translational initiation	4.44	0.00e+00	0.00e+00	41/160	RPL11; RPS27; RPS27A; RPL31; RPL14; RPL24; RPL35A; RPL9; RPL34; RPL37; RPS14; RPS10; EIF1AX; RPS4X; RPL39; RPL10; RPL30; EIF3E; RPLP2; RPL27A; RPS3; RPS25; RPL21; RPS29; RPLP1; RPS15A; RPL13; RPL26; RPL23A; CCL5; RPL23; EIF1; RPL27; RPL38; RPL36; RPS28; UBA52; RPS19; RPL18; RPL13A; RPS11
GO:0048857	neural nucleus development	4.16	2.44e-03	3.43e-02	6/25	YWHAQ; ACTB; CALM1; YWHAE; YWHAH; ATP5J
GO:0002181	cytoplasmic translation	4.15	3.32e-07	3.45e-05	17/71	RPL11; RPL31; RPL24; RPL35A; RPL9; RPL39; RPL30; EIF3E; RPS29; RPLP1; RPL26; RPL38; EEF2; RPL36; RPS28; RPL18; RPL13A
GO:0090150	establishment of protein localization to membrane	3.80	8.88e-16	2.16e-13	45/205	RPL11; RPS27; SRP9; YWHAQ; RPS27A; RPL31; RPL14; RPL24; RPL35A; RPL9; RPL34; RPL37; RPS14; GNB2L1; RPS10; RPS4X; RPL39; RPL10; RPL30; RPLP2; RPL27A; RPS3; RPS25; RPL21; TFDP1; RPS29; CALM1; HSP90AA1; RPLP1; RPS15A; RPL13; YWHAE; RPL26; RPL23A; RPL23; RPL27; RPL38; RPL36; RPS28; UBA52; RPS19; RPL18; RPL13A; RPS11; YWHAH
GO:0006333	chromatin assembly or disassembly	3.71	7.35e-06	4.12e-04	15/70	NASP; H3F3A; HMGB2; H2AFY; HIST1H1C; HIST1H1E; HIST1H1D; HIST1H1B; ANP32B; SET; HELLS; HMGB1; SUPT16H; STRA13; CENPM
GO:0006959	humoral immune response	3.67	2.31e-03	3.39e-02	7/33	HMGN2; HLA-E; RPL39; RPL30; CD59; PHB; RPS19
GO:0030901	midbrain development	3.67	2.31e-03	3.39e-02	7/33	YWHAQ; UQCRQ; ACTB; CALM1; YWHAE; YWHAH; ATP5J
GO:0032355	response to estradiol	3.65	1.20e-03	2.04e-02	8/38	HNRNPD; H2AFZ; ARPC1B; EZH2; GSTP1; PCNA; EEF2; CALR
GO:0006301	postreplication repair	3.57	2.77e-03	3.67e-02	7/34	RPS27A; RPA3; POLD2; RFC2; KIAA0101; PCNA; UBA52
GO:0031099	regeneration	3.54	3.86e-04	8.59e-03	10/49	DHFR; EZH2; GSTP1; CDK4; LCP1; PKM; PHB; TYMS; PCNA; MT-CYB
GO:0071897	DNA biosynthetic process	3.40	9.73e-07	8.85e-05	20/102	CENPF; RPS27A; HNRNPD; CCT5; NHP2; HSP90AB1; RPA3; HNRNPA2B1; POLD2; PPIA; RFC2; HNRNPA1; PTGES3; TFDP1; HSP90AA1; KIAA0101; PHB; TYMS; PCNA; UBA52
GO:0006401	RNA catabolic process	3.40	5.33e-15	9.70e-13	49/250	HNRNPR; RPL11; YBX1; RPS27; RPS27A; RPL31; LSM3; RPL14; RPL24; RPL35A; RPL9; HNRNPD; RPL34; RPL37; RPS14; RPS10; LSM5; RPS4X; RPL39; RPL10; RPL30; EIF3E; SET; RPLP2; RPL27A; RPS3; RPS25; HSPA8; MAGOHB; RPL21; RPS29; RPLP1; RPS15A; RPL13; RPL26; RPL23A; RPL23; RPL27; RPL38; EIF4A3; RPL36; RPS28; HNRNPM; LSM4; UBA52; RPS19; RPL18; RPL13A; RPS11
GO:0051702	interaction with symbiont	3.38	2.01e-03	3.18e-02	8/41	NUCKS1; HSPD1; PSMC3; CFL1; HSPA8; CALM1; ANXA2; CCL5
GO:0001906	cell killing	3.29	3.89e-04	8.59e-03	11/58	HMGN2; PRDX1; IL7R; HLA-E; TUBB; HSP90AB1; HPRT1; RPL30; TUBB4B; CORO1A; RPS19
GO:0046939	nucleotide phosphorylation	3.22	2.76e-03	3.67e-02	8/43	ENO1; DTYMK; PGK1; LDHA; PGAM1; TPI1; PKM; NME1
GO:0071103	DNA conformation change	3.21	2.50e-06	1.65e-04	20/108	NASP; H3F3A; SMC4; HMGB2; H2AFY; HIST1H1C; HIST1H1E; HIST1H1D; HIST1H1B; HNRNPA2B1; MCM7; ANP32B; SMC2; SET; HELLS; HMGB1; NUSAP1; TOP2A; STRA13; CENPM
GO:0035821	modification of morphology or physiology of other organism	3.20	2.77e-04	7.20e-03	12/65	HMGN2; NUCKS1; RPL30; PSMC3; CFL1; HSPA8; CALM1; ANXA2; CCL5; KPNA2; TYMS; RPS19
GO:0051321	meiotic cell cycle	3.20	2.77e-04	7.20e-03	12/65	ASPM; MSH6; ACTR3; SMC4; PTTG1; SMC1A; RAD21; CKS2; SMC2; TOP2A; STRA13; CALR
GO:1902600	proton transmembrane transport	3.00	2.98e-04	7.49e-03	13/75	ATP5G3; COX17; ATP5J2; COX7B; STOML2; COX8A; COX6A1; ATP5G1; ATP5J; MT-CO1; MT-ATP6; MT-CO3; MT-CYB
GO:0009141	nucleoside triphosphate metabolic process	2.96	1.54e-08	1.87e-06	32/187	ENO1; NDUFS5; ATP5G3; DTYMK; NDUFS6; UQCRQ; UQCC2; NUDT1; CYCS; ATP5J2; NDUFB2; PGK1; UQCRB; STOML2; LDHA; HSPA8; PGAM1; TPI1; COX6A1; RAN; DUT; PKM; DCTPP1; ATP5G1; NME1; TYMS; ATP5J; MT-ND2; MT-CO1; MT-ATP6; MT-CO3; MT-CYB
GO:0071824	protein-DNA complex subunit organization	2.95	1.98e-06	1.60e-04	23/135	NASP; ANP32E; CENPF; H3F3A; RPS27A; PTMA; HMGB2; H2AFY; HIST1H1C; HIST1H1E; HIST1H1D; HIST1H1B; RPA3; ANP32B; SET; PSMC3; HELLS; HMGB1; SUPT16H; RPL23; STRA13; UBA52; CENPM
GO:0006260	DNA replication	2.86	2.50e-05	1.14e-03	19/115	NASP; NUCKS1; MSH6; SLBP; MCM3; RPA3; POLD2; RFC2; MCM7; SMC1A; STOML2; SET; RRM1; SSRP1; SUPT16H; DUT; KIAA0101; STRA13; PCNA
GO:0051262	protein tetramerization	2.83	3.81e-03	4.70e-02	9/55	CD74; HPRT1; RRM1; EVL; ANXA2; PKM; DCTPP1; CCL5; RPS19
GO:0006605	protein targeting	2.81	3.88e-10	5.64e-08	42/259	RPL11; RPS27; SRP9; RPS27A; RPL31; HSPD1; RPL14; RPL24; RPL35A; RPL9; RPL34; RPL37; RPS14; RPS10; TOMM7; RPS4X; RPL39; RPL10; RPL30; RPLP2; RPL27A; RPS3; RPS25; HSPA8; RPL21; RPS29; HSP90AA1; RPLP1; RPS15A; RPL13; RPL26; RPL23A; RPL23; RPL27; RPL38; RPL36; RPS28; UBA52; RPS19; RPL18; RPL13A; RPS11
GO:0034341	response to interferon-gamma	2.71	8.22e-04	1.57e-02	13/83	ACTR3; HLA-E; HLA-DRA; HLA-DRB5; HLA-DRB1; HLA-DPA1; HSP90AB1; CD44; EVL; MT2A; CCL5; ACTG1; RPL13A
GO:0032200	telomere organization	2.68	9.23e-04	1.68e-02	13/84	H3F3A; HNRNPD; CCT5; NHP2; HSP90AB1; RPA3; HNRNPA2B1; POLD2; RFC2; HNRNPA1; PTGES3; HSP90AA1; PCNA
GO:0006310	DNA recombination	2.68	6.54e-05	2.51e-03	19/123	SFPQ; NUCKS1; MSH6; HSPD1; ACTL6A; TFRC; WHSC1; HMGB2; IL7R; HIST1H1C; HIST1H1E; HIST1H1D; HIST1H1B; RPA3; RAD21; HMGB1; TOP2A; KPNA2; STRA13
GO:0009636	response to toxic substance	2.61	7.17e-06	4.12e-04	25/166	PRDX1; HSPD1; DHFR; GNB2L1; ACTB; EZH2; HPRT1; TXN; LDHA; GSTP1; RPS3; HNRNPA1; CDK4; CALM1; MT2A; MT1E; TXNDC17; CCL5; PHB; TYMS; PCNA; EEF2; PRDX2; UBA52; MT-CYB
GO:0060326	cell chemotaxis	2.54	3.49e-03	4.38e-02	11/75	HMGB2; CD74; GPSM3; GSTP1; JAML; HMGB1; CORO1A; CCL5; CALR; RPS19; MIF
GO:0009123	nucleoside monophosphate metabolic process	2.54	2.29e-06	1.65e-04	29/198	ENO1; NDUFS5; ATP5G3; DTYMK; NDUFS6; UQCRQ; UQCC2; CYCS; ATP5J2; NDUFB2; PGK1; HPRT1; UQCRB; STOML2; LDHA; HSPA8; PGAM1; TPI1; COX6A1; DUT; PKM; ATP5G1; TYMS; ATP5J; MT-ND2; MT-CO1; MT-ATP6; MT-CO3; MT-CYB
GO:0045787	positive regulation of cell cycle	2.51	3.29e-05	1.33e-03	23/159	SFPQ; CKS1B; MAD2L1; H2AFY; HSP90AB1; EZH2; RAD21; CKS2; KIF20B; CDK4; TFDP1; NUSAP1; RPS15A; RPL26; EVI2B; RPL23; ANAPC11; NDC80; PCNA; UBE2C; CALR; RAD23A; MIF
GO:0048285	organelle fission	2.49	1.13e-05	5.86e-04	26/181	ASPM; CENPF; ACTR3; RPL24; SMC4; MAD2L1; H2AFY; PTTG1; SMC1A; FLNA; RAD21; CKS2; SMC2; KIF20B; MKI67; RAN; NUSAP1; KIF22; TOP2A; ANAPC11; STRA13; NDC80; TPX2; UBE2C; CALR; UBE2S
GO:0007059	chromosome segregation	2.47	8.80e-05	3.20e-03	21/147	SFPQ; CENPF; ACTR3; SMC4; MAD2L1; H2AFY; PTTG1; SMC1A; SLC25A5; RAD21; SMC2; RPS3; MKI67; RAN; NUSAP1; KIF22; TOP2A; SKA2; ANAPC11; STRA13; NDC80
GO:0007006	mitochondrial membrane organization	2.45	3.21e-03	4.10e-02	12/85	YWHAQ; ATP5G3; ATP5J2; SLC25A5; TFDP1; CALM1; HSP90AA1; YWHAE; ATP5G1; YWHAH; ATP5J; MT-ATP6
GO:0010948	negative regulation of cell cycle process	2.44	1.58e-04	4.80e-03	20/142	CENPF; MSH6; MAD2L1; H2AFY; PTTG1; HSP90AB1; EZH2; SMC1A; RAD21; CBX5; CDK4; TFDP1; RPL26; EVI2B; RPL23; NDC80; PCNA; CALR; GLTSCR2; MIF
GO:0046677	response to antibiotic	2.41	5.59e-04	1.13e-02	17/122	HSPD1; HNRNPD; GNB2L1; EZH2; TXN; LDHA; GSTP1; RPS3; FDX1; HNRNPA1; HSP90AA1; RPL23; PHB; TYMS; PCNA; EEF2; MT-CYB
GO:0051052	regulation of DNA metabolic process	2.32	2.91e-05	1.25e-03	27/202	USP1; NUCKS1; MSH6; TFRC; WHSC1; HNRNPD; CCT5; IL7R; DEK; HIST1H1C; HIST1H1E; HIST1H1D; HIST1H1B; HSP90AB1; HNRNPA2B1; RFC2; SMC1A; STOML2; RPS3; HNRNPA1; PTGES3; HMGB1; TFDP1; HSP90AA1; KPNA2; PCNA; DNMT1
GO:0070661	leukocyte proliferation	2.29	2.85e-03	3.70e-02	14/106	HSPD1; TFRC; IL7R; CD74; HLA-E; HLA-DPA1; HPRT1; GSTP1; RPS3; HELLS; HMGB1; CORO1A; CCL5; MIF
GO:1901293	nucleoside phosphate biosynthetic process	2.28	4.01e-04	8.59e-03	20/152	ENO1; ATP5G3; DTYMK; ATP5J2; PGK1; HPRT1; STOML2; RRM1; LDHA; PGAM1; TPI1; ERH; DUT; PKM; IDH2; ATP5G1; NME1; TYMS; ATP5J; MT-ATP6
GO:0010639	negative regulation of organelle organization	2.10	8.61e-04	1.61e-02	21/173	STMN1; CENPF; H3F3A; TMSB10; MAD2L1; H2AFY; PTTG1; HIST1H1C; HIST1H1E; HIST1H1D; HIST1H1B; SLC25A5; RAD21; ATAD2; SET; HNRNPA1; CORO1A; PFN1; TOP2A; NDC80; DNMT1
GO:0071826	ribonucleoprotein complex subunit organization	2.10	5.10e-04	1.06e-02	23/190	RPL11; SRSF10; RPS27; SNRPE; SNRPG; LSM3; RPL24; RPS14; RPS10; HSP90AB1; RPL10; EIF3E; PTGES3; HSP90AA1; RPL23A; RPL38; SNRPD1; SNRPB; RPS28; LSM4; RPS19; GLTSCR2; RPL13A
GO:0060249	anatomical structure homeostasis	2.08	2.28e-03	3.39e-02	18/150	PRDX1; TFRC; HNRNPD; CCT5; NHP2; HSP90AB1; ACTB; RPA3; HNRNPA2B1; POLD2; RFC2; PGK1; HNRNPA1; PTGES3; HSP90AA1; CORO1A; ACTG1; PCNA
GO:0040029	regulation of gene expression, epigenetic	2.07	2.45e-03	3.43e-02	18/151	H3F3A; H2AFY; DEK; HIST1H1C; HIST1H1E; HIST1H1D; HIST1H1B; ACTB; HNRNPA2B1; EZH2; ATAD2; PHF19; POLR2L; HELLS; RAN; HMGB1; EIF1; DNMT1
GO:0033044	regulation of chromosome organization	2.06	6.39e-04	1.26e-02	23/193	SFPQ; CENPF; H3F3A; HNRNPD; MAD2L1; CCT5; H2AFY; PTTG1; HIST1H1C; HIST1H1E; HIST1H1D; HIST1H1B; HNRNPA2B1; RAD21; ATAD2; PHF19; SET; MKI67; HNRNPA1; TOP2A; ANAPC11; NDC80; DNMT1
GO:0006091	generation of precursor metabolites and energy	2.06	1.31e-04	4.15e-03	29/244	ENO1; NDUFS5; COX17; NDUFS6; UQCRQ; UQCC2; CYCS; ATP5J2; NDUFB2; COX7B; PGK1; UQCRB; STOML2; LDHA; COX8A; FDX1; PGAM1; TPI1; COX6A1; HMGB1; PKM; IDH2; GLTSCR2; ATP5J; MT-ND2; MT-CO1; MT-ATP6; MT-CO3; MT-CYB
GO:0044772	mitotic cell cycle phase transition	2.05	1.04e-04	3.62e-03	30/253	NASP; CKS1B; CENPF; MSH6; RPL24; MAD2L1; DHFR; TUBB; MCM3; RPA3; MCM7; EZH2; RAD21; CKS2; TUBB4B; CDK4; TFDP1; PSME2; CALM1; HSP90AA1; YWHAE; RPL26; ANAPC11; TYMS; NDC80; PCNA; TPX2; UBE2C; GLTSCR2; UBE2S
GO:0009259	ribonucleotide metabolic process	2.02	1.88e-04	5.27e-03	29/249	ENO1; NDUFS5; DBI; ATP5G3; NDUFS6; UQCRQ; UQCC2; CYCS; ATP5J2; NDUFB2; PGK1; HPRT1; UQCRB; STOML2; LDHA; HSPA8; PGAM1; TPI1; COX6A1; RAN; PKM; ATP5G1; NME1; ATP5J; MT-ND2; MT-CO1; MT-ATP6; MT-CO3; MT-CYB

MEF2D : 6 significant GO terms

GeneSet	description	enrichRatio	pValue	FDR	GeneRatio	geneSymbols
GO:0002181	cytoplasmic translation	21.90	9.22e-12	1.17e-09	10/71	RPL31; RPL30; RPS26; RPL41; RPS29; RPL38; RPS21; EEF2; RPL36; RPS28
GO:0070972	protein localization to endoplasmic reticulum	19.10	1.11e-16	8.08e-14	15/122	RPS27; RPL31; RPS14; RPL30; RPL12; RPS25; RPS26; RPL41; RPS29; RPL4; RPL38; RPS21; RPL36; RPS28; RPL28
GO:0006413	translational initiation	15.50	2.22e-16	8.08e-14	16/160	RPS27; RPL31; RPS14; RPL30; PABPC1; RPL12; RPS25; RPS26; RPL41; RPS29; RPL4; RPL38; RPS21; RPL36; RPS28; RPL28
GO:0090150	establishment of protein localization to membrane	12.10	1.31e-14	3.18e-12	16/205	RPS27; RPL31; RPS14; RPL30; RPL12; RPS25; RPS26; RPL41; GZMB; RPS29; RPL4; RPL38; RPS21; RPL36; RPS28; RPL28
GO:0006401	RNA catabolic process	9.94	3.04e-13	5.54e-11	16/250	RPS27; RPL31; RPS14; RPL30; PABPC1; RPL12; RPS25; RPS26; RPL41; RPS29; RPL4; RPL38; RPS21; RPL36; RPS28; RPL28
GO:0006605	protein targeting	9.00	9.66e-12	1.17e-09	15/259	RPS27; RPL31; RPS14; RPL30; RPL12; RPS25; RPS26; RPL41; RPS29; RPL4; RPL38; RPS21; RPL36; RPS28; RPL28

RASA2 : 45 significant GO terms

GeneSet	description	enrichRatio	pValue	FDR	GeneRatio	geneSymbols
GO:0045730	respiratory burst	8.89	7.74e-04	1.62e-02	4/13	CD52; PGAM1; NCF4; RAC2
GO:0048013	ephrin receptor signaling pathway	7.71	5.32e-06	4.30e-04	8/30	CDC42; ARPC5; ACTR3; ARPC2; FYN; ACTB; ARPC1B; ACTG1
GO:0034109	homotypic cell-cell adhesion	6.74	5.45e-05	2.20e-03	7/30	CLIC1; ACTB; CD9; ACTN1; ACTG1; MYL12A; LGALS1
GO:0046939	nucleotide phosphorylation	6.05	1.18e-05	7.59e-04	9/43	ENO1; PGK1; LDHA; PFKP; PGAM1; TPI1; PKM; ALDOA; ALDOC
GO:0006090	pyruvate metabolic process	5.78	1.74e-05	9.06e-04	9/45	ENO1; PGK1; LDHA; PFKP; PGAM1; TPI1; PKM; ALDOA; ALDOC
GO:0016052	carbohydrate catabolic process	5.58	2.85e-06	2.97e-04	11/57	ENO1; AOAH; PGK1; LDHA; PFKP; PGAM1; TPI1; FUT8; PKM; ALDOA; ALDOC
GO:0060326	cell chemotaxis	5.40	1.84e-07	2.68e-05	14/75	LYST; CXCR4; LEF1; ITGA1; CD74; AIF1; TMSB4X; JAML; GPR183; IL16; CORO1A; CCL3L3; MIF; RAC2
GO:0097581	lamellipodium organization	5.26	7.99e-04	1.62e-02	6/33	CAPZB; CDC42; ARPC5; ARPC2; ITGB1; RAC2
GO:0009132	nucleoside diphosphate metabolic process	5.10	5.00e-05	2.14e-03	9/51	ENO1; PGK1; LDHA; PFKP; PGAM1; TPI1; PKM; ALDOA; ALDOC
GO:0007015	actin filament organization	5.08	5.76e-11	4.19e-08	23/131	CAPZB; CDC42; CAP1; S100A10; ARPC5; CAPG; ACTR3; ARPC2; AIF1; EZR; ARPC1B; TMSB4X; CFL1; ITGB1; LCP1; ACTN1; EVL; ALDOA; CORO1A; FAM101B; PFN1; TPM4; RAC2
GO:0007229	integrin-mediated signaling pathway	4.96	1.11e-03	1.96e-02	6/35	CDC42; ITGA4; FYB; ITGA1; ITGB1; FUT8
GO:0070671	response to interleukin-12	4.96	1.11e-03	1.96e-02	6/35	CDC42; CFL1; RPLP0; LCP1; P4HB; MIF
GO:0050900	leukocyte migration	4.54	2.09e-08	4.40e-06	19/121	CD2; CD84; CD48; LYST; CXCR4; ITGA4; ITGA1; CD74; AIF1; FYN; JAML; ITGB1; GPR183; IL16; CORO1A; CCL3L3; ADA; MIF; RAC2
GO:0006909	phagocytosis	4.40	2.48e-06	2.97e-04	14/92	CDC42; ARPC5; ACTR3; ARPC2; LYAR; AIF1; FYN; ACTB; ARPC1B; CD3G; ITGB1; CORO1A; ACTG1; NCF4
GO:0050920	regulation of chemotaxis	4.36	4.08e-04	1.02e-02	8/53	CXCR4; CD74; AIF1; TMSB4X; GPR183; IL16; MIF; RAC2
GO:0034341	response to interferon-gamma	4.18	2.28e-05	1.11e-03	12/83	GBP1; ACTR3; AIF1; HLA-DRA; HLA-DRB5; HLA-DRB1; HLA-DQB1; HLA-DPA1; HLA-DPB1; EVL; CCL3L3; ACTG1
GO:0072524	pyridine-containing compound metabolic process	4.00	3.47e-04	9.35e-03	9/65	ENO1; PGK1; LDHA; PFKP; PGAM1; TPI1; PKM; ALDOA; ALDOC
GO:0070661	leukocyte proliferation	3.82	1.36e-05	7.62e-04	14/106	SATB1; LEF1; CD74; AIF1; HLA-DPA1; HLA-DPB1; FYN; RPS3; GPR183; CORO1A; IKZF3; ADA; MIF; RAC2
GO:0031589	cell-substrate adhesion	3.81	5.83e-05	2.24e-03	12/91	CDC42; GBP1; S100A10; ITGA4; ARPC2; CD96; ITGA1; ITGB1; ACTN1; CORO1A; RAC2; LGALS1
GO:0032970	regulation of actin filament-based process	3.79	3.52e-06	3.21e-04	16/122	CAPZB; CDC42; S100A10; ARPC5; CAPG; ACTR3; ARPC2; ABRACL; EZR; ARPC1B; TMSB4X; CFL1; ARHGDIB; EVL; CORO1A; PFN1
GO:0046434	organophosphate catabolic process	3.75	2.78e-04	8.11e-03	10/77	ENO1; PGK1; LDHA; PFKP; PGAM1; TPI1; PKM; ALDOA; ALDOC; ADA
GO:0016051	carbohydrate biosynthetic process	3.72	6.08e-04	1.42e-02	9/70	ENO1; PASK; PGK1; CSGALNACT1; PGAM1; TPI1; FUT8; ALDOA; ALDOC
GO:0042110	T cell activation	3.61	6.65e-09	2.42e-06	26/208	CDC42; CD2; CD8A; CD8B; SATB1; TIGIT; LEF1; CD74; AIF1; HLA-DPA1; HLA-DPB1; FYN; RPS3; JAML; CD3D; CD3G; LCP1; GPR183; BCL11B; CORO1A; CD7; ADA; XBP1; RAC2; LGALS1; GRAP2
GO:0060491	regulation of cell projection assembly	3.45	1.99e-03	3.29e-02	8/67	CAPZB; CDC42; ARPC2; SYNE2; EVL; PFN1; SEPT9; RAC2
GO:0019882	antigen processing and presentation	3.42	3.19e-04	8.94e-03	11/93	CAPZB; CD8A; KIF2A; CD74; HLA-DRA; HLA-DRB5; HLA-DRB1; HLA-DQB1; HLA-DPA1; HLA-DPB1; CTSD
GO:0002764	immune response-regulating signaling pathway	3.40	2.42e-08	4.40e-06	26/221	CDC42; GBP1; ARPC5; ACTR3; ARPC2; TIFA; FYB; NCR3; HLA-DRA; HLA-DRB5; HLA-DRB1; HLA-DQB1; HLA-DPA1; HLA-DPB1; FYN; EZR; ACTB; ARPC1B; MFHAS1; RPS3; CD3D; CD3G; PLEKHA1; ACTG1; ADA; GRAP2
GO:0034404	nucleobase-containing small molecule biosynthetic process	3.40	6.25e-04	1.42e-02	10/85	ENO1; PGK1; LDHA; PFKP; PGAM1; TPI1; PKM; ALDOA; ALDOC; ADA
GO:0007159	leukocyte cell-cell adhesion	3.30	1.18e-05	7.59e-04	17/149	CDC42; ITGA4; TIGIT; CD74; AIF1; HLA-DPA1; HLA-DPB1; FYN; EZR; RPS3; ITGB1; CORO1A; ADA; XBP1; RAC2; LGALS1; GRAP2
GO:0050867	positive regulation of cell activation	3.28	4.15e-05	1.89e-03	15/132	CDC42; CD2; CD74; AIF1; HLA-DPA1; HLA-DPB1; FYN; RPS3; GPR183; CORO1A; ADA; MIF; XBP1; LGALS1; GRAP2
GO:1902903	regulation of supramolecular fiber organization	3.16	1.15e-04	3.99e-03	14/128	CAPZB; CDC42; S100A10; ARPC5; CAPG; ACTR3; ARPC2; ARPC1B; TMSB4X; CFL1; RPS3; EVL; CORO1A; PFN1
GO:0016053	organic acid biosynthetic process	3.13	2.24e-04	6.78e-03	13/120	ENO1; CD74; PGK1; LDHA; PFKP; PGAM1; TPI1; ALOX5AP; PKM; ALDOA; ALDOC; MIF; XBP1
GO:0005996	monosaccharide metabolic process	3.11	1.27e-03	2.15e-02	10/93	ENO1; PASK; PGK1; PFKP; PGAM1; TPI1; FUT8; PKM; ALDOA; ALDOC
GO:0022407	regulation of cell-cell adhesion	3.02	6.40e-05	2.33e-03	16/153	CDC42; ITGA4; TIGIT; LEF1; CD74; AIF1; HLA-DPA1; HLA-DPB1; FYN; RPS3; CD9; CORO1A; ADA; XBP1; LGALS1; GRAP2
GO:0050817	coagulation	3.00	9.86e-04	1.94e-02	11/106	CAPZB; CDC42; H3F3A; CLIC1; FYN; ACTB; CD59; CD9; ACTN1; ACTG1; MYL12A
GO:0042113	B cell activation	2.97	1.07e-03	1.96e-02	11/107	ITGA4; LEF1; CD74; ITM2A; ITGB1; GPR183; IKZF3; ADA; MIF; XBP1; LGALS1
GO:0051258	protein polymerization	2.96	6.48e-04	1.43e-02	12/117	CAPZB; ARPC5; CAPG; ACTR3; ARPC2; AIF1; ARPC1B; TMSB4X; RPS3; EVL; CORO1A; PFN1
GO:0002694	regulation of leukocyte activation	2.92	1.25e-05	7.59e-04	20/198	CDC42; CD2; CD84; TIGIT; CD74; AIF1; HLA-DPA1; HLA-DPB1; FYN; MFHAS1; RPS3; GPR183; CORO1A; IKZF3; ADA; MIF; XBP1; RAC2; LGALS1; GRAP2
GO:0045785	positive regulation of cell adhesion	2.91	1.68e-04	5.57e-03	15/149	CDC42; S100A10; ITGA4; ARPC2; CD74; AIF1; HLA-DPA1; HLA-DPB1; FYN; RPS3; CORO1A; ADA; XBP1; LGALS1; GRAP2
GO:0002250	adaptive immune response	2.87	1.96e-04	6.19e-03	15/151	CD84; CD48; CD8A; CD8B; LEF1; CD74; HLA-DQB1; FYN; CTSC; CD3D; CD3G; GPR183; CD7; ADA; LAIR1
GO:0090066	regulation of anatomical structure size	2.83	3.74e-04	9.71e-03	14/143	CAPZB; ARPC5; CAPG; ACTR3; ARPC2; ITGA1; EZR; ARPC1B; TMSB4X; CFL1; TMEM123; EVL; CORO1A; PFN1
GO:0072522	purine-containing compound biosynthetic process	2.75	1.26e-03	2.15e-02	12/126	ENO1; TMSB4X; PGK1; LDHA; ATP5L; PFKP; PGAM1; TPI1; PKM; ALDOA; ALDOC; ADA
GO:0050878	regulation of body fluid levels	2.67	1.07e-03	1.96e-02	13/141	CAPZB; CDC42; H3F3A; CLIC1; FYN; ACTB; CD59; CD9; ACTN1; ACTG1; MYL12A; ADA; XBP1
GO:0046390	ribose phosphate biosynthetic process	2.63	2.89e-03	4.68e-02	11/121	ENO1; TMSB4X; PGK1; LDHA; ATP5L; PFKP; PGAM1; TPI1; PKM; ALDOA; ALDOC
GO:0051493	regulation of cytoskeleton organization	2.43	7.86e-04	1.62e-02	16/190	CAPZB; CDC42; S100A10; ARPC5; CAPG; ACTR3; ARPC2; EZR; ARPC1B; TMSB4X; CFL1; RPS3; ARHGDIB; EVL; CORO1A; PFN1
GO:0002521	leukocyte differentiation	2.42	5.73e-04	1.39e-02	17/203	CDC42; CD2; CD8A; ITGA4; SATB1; LEF1; CD74; ITM2A; CD3D; CD3G; ITGB1; GPR183; BCL11B; IKZF3; ADA; XBP1; LGALS1

TCEB2 : 44 significant GO terms

GeneSet	description	enrichRatio	pValue	FDR	GeneRatio	geneSymbols
GO:0006090	pyruvate metabolic process	4.74	4.33e-06	5.26e-04	12/45	ENO1; GLO1; PGK1; LDHA; PFKP; DDIT4; PGAM1; GAPDH; TPI1; PKM; ALDOA; ALDOC
GO:0070972	protein localization to endoplasmic reticulum	4.66	5.04e-14	1.83e-11	32/122	RPL5; RPS27; RPS27A; RPSA; RPL34; RPS3A; RPL37; RPS23; RPS18; RPL39; RPL10; RPL30; RPL8; RPL35; HSPA5; RPL12; RPL7A; RPS13; RPS24; RPL6; RPLP0; RPL21; RPS27L; RPLP1; RPS2; RPL27; RPS19; KDELR1; RPL13A; RPS9; RPL28; RPS5; RPL3
GO:0046939	nucleotide phosphorylation	4.54	1.69e-05	1.12e-03	11/43	ENO1; PGK1; LDHA; PFKP; DDIT4; PGAM1; GAPDH; TPI1; PKM; ALDOA; ALDOC
GO:0006413	translational initiation	4.44	2.22e-16	1.62e-13	40/160	RPL5; RPS27; RPS27A; RPSA; EIF2A; RPL34; RPS3A; RPL37; RPS23; NPM1; RPS18; EIF2S3; RPL39; RPL10; RPL30; EIF3E; EIF3H; RPL8; RPL35; RPL12; RPL7A; RPS13; EIF3M; RPS24; RPL6; RPLP0; RPL21; RPS27L; RPLP1; RPS2; EIF4A1; EIF1; RPL27; RPS19; RPL13A; RPS9; RPL28; RPS5; EIF3D; RPL3; ATF4
GO:0016052	carbohydrate catabolic process	4.05	1.13e-05	9.56e-04	13/57	ENO1; AOAH; PGK1; LDHA; PFKP; DDIT4; PGAM1; GAPDH; TPI1; FUT8; PKM; ALDOA; ALDOC
GO:0046683	response to organophosphorus	3.95	6.94e-04	1.61e-02	8/36	SELL; HSPD1; EZR; HSPA5; LDHA; HSP90B1; ZFP36L1; TYMS
GO:0009132	nucleoside diphosphate metabolic process	3.83	9.36e-05	4.01e-03	11/51	ENO1; PGK1; LDHA; PFKP; DDIT4; PGAM1; GAPDH; TPI1; PKM; ALDOA; ALDOC
GO:0072524	pyridine-containing compound metabolic process	3.55	5.04e-05	2.62e-03	13/65	ENO1; TKT; PGK1; NMRK1; LDHA; PFKP; DDIT4; PGAM1; GAPDH; TPI1; PKM; ALDOA; ALDOC
GO:0051702	interaction with symbiont	3.46	1.72e-03	3.29e-02	8/41	HSPD1; GPX1; CFL1; HSPA8; GAPDH; CALM1; ANXA2; PPIB
GO:0090150	establishment of protein localization to membrane	3.38	5.45e-12	9.92e-10	39/205	RPL5; RPS27; SSR2; YWHAQ; RPS27A; RPSA; RPL34; RPS3A; RPL37; RPS23; RPS18; RPL39; RPL10; GOLGA7; RPL30; RPL8; RPL35; RPL12; RPL7A; RPS13; RPS24; RPL6; RPLP0; RILPL2; RPL21; GZMB; CALM1; RPS27L; RPLP1; RPS2; RPL27; YWHAB; RPS19; BBC3; BAX; RPL13A; RPS9; RPL28; RPS5; RPL3
GO:0060326	cell chemotaxis	3.31	5.81e-05	2.82e-03	14/75	ITGA1; FAM65B; AIF1; GPSM3; TMSB4X; CXCR3; FGFR1; JAML; LGALS3; IL16; CKLF; RPS19; MIF; RAC2
GO:0002576	platelet degranulation	3.30	2.36e-03	4.09e-02	8/43	OLA1; TMSB4X; CTSW; SRGN; CD9; CD63; CALM1; ALDOA
GO:0002181	cytoplasmic translation	3.25	1.32e-04	5.32e-03	13/71	RPS23; EIF2S3; RPL39; RPL30; EIF3E; EIF3H; RPL8; EIF3M; RPL6; RPLP0; RPLP1; RPL13A; EIF3D
GO:0006401	RNA catabolic process	3.13	3.38e-12	8.20e-10	44/250	YBX1; RPL5; RPS27; ZFP36L2; RPS27A; RPSA; FXR1; RPL34; RPS3A; RPL37; RPS23; NPM1; LSM2; RPS18; RPL39; RPL10; RPL30; EIF3E; RPL8; RPL35; RPL12; RPL7A; RPS13; ATM; HSPA8; VIM; RPS24; RPL6; RPLP0; RPL21; ZFP36L1; RPS27L; RPLP1; ISG20; RPS2; CARHSP1; RPL27; DDX5; YWHAB; RPS19; RPL13A; RPS9; RPL28; RPS5; RPL3
GO:0008637	apoptotic mitochondrial changes	3.10	6.61e-04	1.61e-02	11/63	YWHAQ; HSPD1; GPX1; FAM162A; BNIP3L; BNIP3; TRIAP1; GZMB; YWHAB; BBC3; BAX
GO:0001906	cell killing	3.06	1.28e-03	2.52e-02	10/58	SLAMF7; HAVCR2; RPL30; CTSC; GAPDH; LAG3; GZMB; B2M; GZMM; RPS19
GO:0046434	organophosphate catabolic process	3.00	3.07e-04	9.60e-03	13/77	ENO1; GPX1; HINT1; PGK1; LDHA; PFKP; DDIT4; PGAM1; GAPDH; TPI1; PKM; ALDOA; ALDOC
GO:0043270	positive regulation of ion transport	2.96	2.83e-03	4.58e-02	9/54	TMSB4X; GSTO1; TRIAP1; LGALS3; CALM1; ANXA2; BAX; MIF; ATF4
GO:0006605	protein targeting	2.95	4.62e-11	6.73e-09	43/259	RPL5; RPS27; SSR2; RPS27A; HSPD1; RPSA; RPL34; RPS3A; RPL37; RPS23; RPS18; PMPCB; GSTK1; SLC25A6; RPL39; RPL10; BNIP3L; GOLGA7; RPL30; RPL8; RPL35; RPL12; RPL7A; RPS13; SORL1; HSPA8; RPS24; GNPTAB; RPL6; RPLP0; RPL21; RPS27L; RPLP1; RPS2; UQCRC2; RPL27; YWHAB; RPS19; RPL13A; RPS9; RPL28; RPS5; RAC2; RPL3
GO:0050900	leukocyte migration	2.94	1.05e-05	9.56e-04	20/121	CD2; CD48; SELL; ITGA4; ITGA1; FAM65B; AIF1; GPSM3; PPIA; MYO1G; CXCR3; CD44; SLC3A2; JAML; LGALS3; IL16; CKLF; RPS19; MIF; RAC2
GO:0034404	nucleobase-containing small molecule biosynthetic process	2.92	2.37e-04	8.61e-03	14/85	ENO1; GPX1; HINT1; PGK1; NMRK1; LDHA; PFKP; DDIT4; PGAM1; GAPDH; TPI1; PKM; ALDOA; ALDOC
GO:0046390	ribose phosphate biosynthetic process	2.79	3.69e-05	2.24e-03	19/121	ENO1; ATP5F1; ELOVL5; TMSB4X; PGK1; NMRK1; LDHA; ATP5L; PFKP; DDIT4; PGAM1; GAPDH; TPI1; ATP5G2; ATP5B; PKM; ALDOA; ALDOC; ATP5D
GO:0009410	response to xenobiotic stimulus	2.77	2.76e-03	4.56e-02	10/64	HSPD1; GPX1; AIF1; HSPA5; DDIT4; GSTO1; RGS10; MDM2; CALM1; PCNA
GO:0035821	modification of morphology or physiology of other organism	2.73	3.10e-03	4.70e-02	10/65	SLC25A6; RPL30; CFL1; HSPA8; GAPDH; CALM1; ANXA2; PPIB; TYMS; RPS19
GO:0007006	mitochondrial membrane organization	2.72	8.22e-04	1.81e-02	13/85	ATP5F1; YWHAQ; BNIP3L; ATP5L; BNIP3; ATP5G2; ATP5B; GZMB; CALM1; YWHAB; ATP5D; BBC3; BAX
GO:0005996	monosaccharide metabolic process	2.67	6.15e-04	1.60e-02	14/93	ENO1; TKT; PGK1; FABP5; PFKP; PGAM1; GSTO1; GAPDH; TPI1; FUT8; PKM; ALDOA; ALDOC; ATF4
GO:0034341	response to interferon-gamma	2.57	2.13e-03	3.88e-02	12/83	AIF1; ZYX; IFITM2; TRIM22; CD44; VIM; GAPDH; B2M; MT2A; ACTG1; BST2; RPL13A
GO:0072522	purine-containing compound biosynthetic process	2.54	2.07e-04	7.94e-03	18/126	ENO1; ATP5F1; ELOVL5; TMSB4X; PGK1; LDHA; ATP5L; PFKP; DDIT4; PGAM1; GAPDH; TPI1; ATP5G2; ATP5B; PKM; ALDOA; ALDOC; ATP5D
GO:0032103	positive regulation of response to external stimulus	2.48	2.89e-03	4.58e-02	12/86	HSPD1; HAVCR2; FAM65B; AIF1; GPSM3; TMSB4X; FGFR1; IL16; TRADD; RPS19; MIF; RAC2
GO:0009141	nucleoside triphosphate metabolic process	2.47	1.31e-05	9.56e-04	26/187	ENO1; UQCRH; ATP5F1; COX7A2L; OLA1; NDUFB5; PMPCB; TMSB4X; PGK1; LDHA; ATP5L; HSPA8; PFKP; DDIT4; PGAM1; GAPDH; TPI1; ATP5G2; ATP5B; PKM; UQCRC2; ALDOA; ALDOC; TYMS; ATP5D; MT-ND2
GO:0009123	nucleoside monophosphate metabolic process	2.42	1.28e-05	9.56e-04	27/198	ENO1; UQCRH; ATP5F1; COX7A2L; OLA1; NDUFB5; PMPCB; TMSB4X; PGK1; NMRK1; LDHA; ATP5L; HSPA8; PFKP; DDIT4; PGAM1; GAPDH; TPI1; ATP5G2; ATP5B; PKM; UQCRC2; ALDOA; ALDOC; TYMS; ATP5D; MT-ND2
GO:0035690	cellular response to drug	2.39	9.21e-04	1.97e-02	16/119	AIF1; MYB; ACTB; ZNF277; MYC; HSPA5; VIM; DDIT4; RGS10; BNIP3; MDM2; HSP90B1; MT2A; PCNA; KLF2; ATF4
GO:0070482	response to oxygen levels	2.37	4.94e-04	1.33e-02	18/135	ENO1; RPS27A; HSPD1; FAM162A; MYB; PGK1; BNIP3L; MYC; LDHA; ATM; DDIT4; BNIP3; MDM2; HSP90B1; ZFP36L1; PKM; TCEB2; ATF4
GO:1901293	nucleoside phosphate biosynthetic process	2.34	2.90e-04	9.60e-03	20/152	ENO1; ATP5F1; ELOVL5; TMSB4X; PGK1; NMRK1; LDHA; ATP5L; PFKP; DDIT4; PGAM1; GAPDH; TPI1; ATP5G2; ATP5B; PKM; ALDOA; ALDOC; TYMS; ATP5D
GO:0071826	ribonucleoprotein complex subunit organization	2.34	5.03e-05	2.62e-03	25/190	RPL5; RPS27; RPSA; EIF2A; RPS23; NPM1; EIF2S3; RPL10; ZFAND1; EIF3E; EIF3H; RPL12; EIF3M; ATM; SNRPF; RPL6; RPLP0; RSL24D1; RPS27L; ZNHIT3; RPS19; RPL13A; RPS5; EIF3D; RPL3
GO:2001233	regulation of apoptotic signaling pathway	2.33	7.54e-05	3.43e-03	24/183	ENO1; YWHAQ; ITM2C; GPX1; FAM162A; NONO; FGFR1; CD44; CTSC; VDAC2; BNIP3; MDM2; ERP29; TRIAP1; TPT1; GZMB; LGALS3; PDIA3; TRADD; YWHAB; CDKN2D; BBC3; BAX; MIF
GO:0052547	regulation of peptidase activity	2.32	3.16e-04	9.60e-03	20/153	BIN1; HSPD1; GPX1; FAM162A; IGBP1; NGFRAP1; MYC; ANP32B; CD44; UBXN1; SORL1; GAPDH; MDM2; TRIAP1; RPS27L; TRADD; CDKN2D; BST2; BBC3; BAX
GO:0007015	actin filament organization	2.30	9.66e-04	2.01e-02	17/131	RHOC; S100A10; TMSB10; CAPG; BIN1; BRK1; AIF1; EZR; ARPC1B; ZYX; TMSB4X; CFL1; HSP90B1; ALDOA; FAM101B; PFN1; RAC2
GO:0104004	cellular response to environmental stimulus	2.30	7.06e-04	1.61e-02	18/139	HIST3H2A; XPC; NPM1; FAM65B; ZFAND1; MYC; EEF1D; HSPA5; DDB2; ATM; BNIP3; MDM2; TRIAP1; ZFP36L1; CALM1; PCNA; BAX; ATF4
GO:0097193	intrinsic apoptotic signaling pathway	2.28	4.10e-04	1.15e-02	20/156	ENO1; GPX1; HINT1; NONO; CD44; ATM; DDIT4; VDAC2; BNIP3; MDM2; ERP29; TRIAP1; TPT1; RPS27L; DDX5; CDKN2D; BBC3; BAX; MIF; ATF4
GO:0009636	response to toxic substance	2.25	3.55e-04	1.03e-02	21/166	TXNIP; HSPD1; GPX1; MYB; ACTB; ZNF277; GSTK1; LDHA; GSTO1; RGS10; BNIP3; MDM2; CALM1; MT2A; MT1E; MT1F; TYMS; PCNA; KLF2; BAX; ATF4
GO:0006732	coenzyme metabolic process	2.11	2.55e-03	4.32e-02	17/143	ENO1; TKT; ELOVL5; PGK1; NMRK1; LDHA; PFKP; PCBD1; DDIT4; PGAM1; GSTO1; GAPDH; TPI1; PKM; ALDOA; ALDOC; TYMS
GO:0098542	defense response to other organism	2.08	2.33e-03	4.09e-02	18/154	PLAC8; HAVCR2; RPL39; BNIP3L; RPL30; IFITM2; TRIM22; IL2RA; DDX21; DDIT4; BNIP3; GAPDH; PCBP2; ISG20; BST2; RPS19; APOBEC3H; IFNAR2
GO:0002683	negative regulation of immune system process	2.02	3.09e-03	4.70e-02	18/158	GPX1; CD96; HAVCR2; FAM65B; EZR; MYC; PHPT1; CD59; ATM; IL2RA; LAG3; PCBP2; LGALS3; ZFP36L1; BST2; RPS19; MIF; SAMSN1

Summary:
Marker	CDKN1B	MEF2D	RASA2	TCEB2
Signif_GO_terms	55	6	45	44

4.2 Reactome Pathway Over-Representation Analysis

Gene sets: The Reactome pathway database.

CDKN1B : 151 significant Reactome pathways

GeneSet	description	enrichRatio	pValue	FDR	GeneRatio	geneSymbols
R-HSA-5334118	DNA methylation	9.90	8.14e-07	2.02e-05	7/10	HIST2H2AC; H3F3A; H2AFZ; HIST1H4C; H2AFV; H3F3B; DNMT1
R-HSA-2299718	Condensation of Prophase Chromosomes	9.79	2.15e-08	5.82e-07	9/13	HIST2H2AC; H3F3A; SMC4; H2AFZ; HIST1H4C; H2AFV; SMC2; SET; H3F3B
R-HSA-69190	DNA strand elongation	8.49	1.95e-05	3.26e-04	6/10	MCM3; RPA3; POLD2; RFC2; MCM7; PCNA
R-HSA-140342	Apoptosis induced DNA fragmentation	8.49	1.95e-05	3.26e-04	6/10	HMGB2; HIST1H1C; HIST1H1E; HIST1H1D; HIST1H1B; HMGB1
R-HSA-211227	Activation of DNA fragmentation factor	8.49	1.95e-05	3.26e-04	6/10	HMGB2; HIST1H1C; HIST1H1E; HIST1H1D; HIST1H1B; HMGB1
R-HSA-3371511	HSF1 activation	7.72	4.03e-05	6.02e-04	6/11	HSP90AB1; EEF1A1; RPA3; PTGES3; HSP90AA1; YWHAE
R-HSA-73728	RNA Polymerase I Promoter Opening	7.72	4.03e-05	6.02e-04	6/11	HIST2H2AC; H3F3A; H2AFZ; HIST1H4C; H2AFV; H3F3B
R-HSA-5626467	RHO GTPases activate IQGAPs	7.07	4.39e-06	9.28e-05	8/16	CALM2; ACTB; TUBB4B; TUBA1B; TUBA1C; CALM1; ACTG1; CALM3
R-HSA-8876725	Protein methylation	7.07	7.58e-05	1.03e-03	6/12	CALM2; EEF1A1; HSPA8; CALM1; EEF2; CALM3
R-HSA-427359	SIRT1 negatively regulates rRNA expression	7.07	7.58e-05	1.03e-03	6/12	HIST2H2AC; H3F3A; H2AFZ; HIST1H4C; H2AFV; H3F3B
R-HSA-5625886	Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3	7.07	7.58e-05	1.03e-03	6/12	HIST2H2AC; H3F3A; H2AFZ; HIST1H4C; H2AFV; H3F3B
R-HSA-156902	Peptide chain elongation	6.74	0.00e+00	0.00e+00	40/84	RPL11; RPS27; RPS27A; RPL31; RPL14; RPL24; RPL22L1; RPL35A; RPL9; RPL34; RPL37; RPS14; RPS10; EEF1A1; RPS4X; RPL39; RPL10; RPL30; RPLP2; RPL27A; RPS3; RPS25; RPL21; RPS29; RPLP1; RPS15A; RPL13; RPL26; RPL23A; RPL23; RPL27; RPL38; EEF2; RPL36; RPS28; UBA52; RPS19; RPL18; RPL13A; RPS11
R-HSA-156842	Eukaryotic Translation Elongation	6.50	0.00e+00	0.00e+00	40/87	RPL11; RPS27; RPS27A; RPL31; RPL14; RPL24; RPL22L1; RPL35A; RPL9; RPL34; RPL37; RPS14; RPS10; EEF1A1; RPS4X; RPL39; RPL10; RPL30; RPLP2; RPL27A; RPS3; RPS25; RPL21; RPS29; RPLP1; RPS15A; RPL13; RPL26; RPL23A; RPL23; RPL27; RPL38; EEF2; RPL36; RPS28; UBA52; RPS19; RPL18; RPL13A; RPS11
R-HSA-192823	Viral mRNA Translation	6.40	0.00e+00	0.00e+00	38/84	RPL11; RPS27; RPS27A; RPL31; RPL14; RPL24; RPL22L1; RPL35A; RPL9; RPL34; RPL37; RPS14; RPS10; RPS4X; RPL39; RPL10; RPL30; RPLP2; RPL27A; RPS3; RPS25; RPL21; RPS29; RPLP1; RPS15A; RPL13; RPL26; RPL23A; RPL23; RPL27; RPL38; RPL36; RPS28; UBA52; RPS19; RPL18; RPL13A; RPS11
R-HSA-212300	PRC2 methylates histones and DNA	6.37	3.24e-06	7.01e-05	9/20	HIST2H2AC; H3F3A; H2AFZ; HIST1H4C; H2AFV; EZH2; PHF19; H3F3B; DNMT1
R-HSA-2408557	Selenocysteine synthesis	6.32	0.00e+00	0.00e+00	38/85	RPL11; RPS27; RPS27A; RPL31; RPL14; RPL24; RPL22L1; RPL35A; RPL9; RPL34; RPL37; RPS14; RPS10; RPS4X; RPL39; RPL10; RPL30; RPLP2; RPL27A; RPS3; RPS25; RPL21; RPS29; RPLP1; RPS15A; RPL13; RPL26; RPL23A; RPL23; RPL27; RPL38; RPL36; RPS28; UBA52; RPS19; RPL18; RPL13A; RPS11
R-HSA-912446	Meiotic recombination	6.29	1.32e-05	2.54e-04	8/18	HIST2H2AC; H3F3A; H2AFZ; HIST1H4C; RPA3; H2AFV; CDK4; H3F3B
R-HSA-72764	Eukaryotic Translation Termination	6.18	0.00e+00	0.00e+00	38/87	RPL11; RPS27; RPS27A; RPL31; RPL14; RPL24; RPL22L1; RPL35A; RPL9; RPL34; RPL37; RPS14; RPS10; RPS4X; RPL39; RPL10; RPL30; RPLP2; RPL27A; RPS3; RPS25; RPL21; RPS29; RPLP1; RPS15A; RPL13; RPL26; RPL23A; RPL23; RPL27; RPL38; RPL36; RPS28; UBA52; RPS19; RPL18; RPL13A; RPS11
R-HSA-975956	Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)	6.11	0.00e+00	0.00e+00	38/88	RPL11; RPS27; RPS27A; RPL31; RPL14; RPL24; RPL22L1; RPL35A; RPL9; RPL34; RPL37; RPS14; RPS10; RPS4X; RPL39; RPL10; RPL30; RPLP2; RPL27A; RPS3; RPS25; RPL21; RPS29; RPLP1; RPS15A; RPL13; RPL26; RPL23A; RPL23; RPL27; RPL38; RPL36; RPS28; UBA52; RPS19; RPL18; RPL13A; RPS11
R-HSA-72689	Formation of a pool of free 40S subunits	5.96	0.00e+00	0.00e+00	40/95	RPL11; RPS27; RPS27A; RPL31; RPL14; RPL24; RPL22L1; RPL35A; RPL9; RPL34; RPL37; RPS14; RPS10; EIF1AX; RPS4X; RPL39; RPL10; RPL30; EIF3E; RPLP2; RPL27A; RPS3; RPS25; RPL21; RPS29; RPLP1; RPS15A; RPL13; RPL26; RPL23A; RPL23; RPL27; RPL38; RPL36; RPS28; UBA52; RPS19; RPL18; RPL13A; RPS11
R-HSA-157858	Gap junction trafficking and regulation	5.89	8.90e-04	8.30e-03	5/12	ACTB; TUBB4B; TUBA1B; TUBA1C; ACTG1
R-HSA-190828	Gap junction trafficking	5.89	8.90e-04	8.30e-03	5/12	ACTB; TUBB4B; TUBA1B; TUBA1C; ACTG1
R-HSA-2559584	Formation of Senescence-Associated Heterochromatin Foci (SAHF)	5.89	8.90e-04	8.30e-03	5/12	LMNB1; HIST1H1C; HIST1H1E; HIST1H1D; HIST1H1B
R-HSA-3928662	EPHB-mediated forward signaling	5.82	8.56e-05	1.09e-03	7/17	ARPC5; ACTR3; ARPC2; ACTB; ARPC1B; CFL1; ACTG1
R-HSA-499943	Interconversion of nucleotide di- and triphosphates	5.82	8.56e-05	1.09e-03	7/17	DTYMK; TXN; RRM1; DUT; DCTPP1; NME1; TYMS
R-HSA-171306	Packaging Of Telomere Ends	5.66	3.65e-03	2.45e-02	4/10	HIST2H2AC; H2AFZ; HIST1H4C; H2AFV
R-HSA-174417	Telomere C-strand (Lagging Strand) Synthesis	5.66	3.65e-03	2.45e-02	4/10	RPA3; POLD2; RFC2; PCNA
R-HSA-5358508	Mismatch Repair	5.66	3.65e-03	2.45e-02	4/10	MSH6; RPA3; POLD2; PCNA
R-HSA-983189	Kinesins	5.44	1.36e-03	1.13e-02	5/13	TUBB4B; KIF20B; TUBA1B; TUBA1C; KIF22
R-HSA-110312	Translesion synthesis by REV1	5.44	1.36e-03	1.13e-02	5/13	RPS27A; RPA3; RFC2; PCNA; UBA52
R-HSA-5656121	Translesion synthesis by POLI	5.44	1.36e-03	1.13e-02	5/13	RPS27A; RPA3; RFC2; PCNA; UBA52
R-HSA-2408522	Selenoamino acid metabolism	5.43	0.00e+00	0.00e+00	38/99	RPL11; RPS27; RPS27A; RPL31; RPL14; RPL24; RPL22L1; RPL35A; RPL9; RPL34; RPL37; RPS14; RPS10; RPS4X; RPL39; RPL10; RPL30; RPLP2; RPL27A; RPS3; RPS25; RPL21; RPS29; RPLP1; RPS15A; RPL13; RPL26; RPL23A; RPL23; RPL27; RPL38; RPL36; RPS28; UBA52; RPS19; RPL18; RPL13A; RPS11
R-HSA-156827	L13a-mediated translational silencing of Ceruloplasmin expression	5.39	0.00e+00	0.00e+00	40/105	RPL11; RPS27; RPS27A; RPL31; RPL14; RPL24; RPL22L1; RPL35A; RPL9; RPL34; RPL37; RPS14; RPS10; EIF1AX; RPS4X; RPL39; RPL10; RPL30; EIF3E; RPLP2; RPL27A; RPS3; RPS25; RPL21; RPS29; RPLP1; RPS15A; RPL13; RPL26; RPL23A; RPL23; RPL27; RPL38; RPL36; RPS28; UBA52; RPS19; RPL18; RPL13A; RPS11
R-HSA-927802	Nonsense-Mediated Decay (NMD)	5.39	0.00e+00	0.00e+00	40/105	RPL11; RPS27; RPS27A; RPL31; RPL14; RPL24; RPL22L1; RPL35A; RPL9; RPL34; RPL37; RPS14; RPS10; RPS4X; RPL39; RPL10; RPL30; RPLP2; RPL27A; RPS3; RPS25; MAGOHB; RPL21; RPS29; RPLP1; RPS15A; RPL13; RPL26; RPL23A; RPL23; RPL27; RPL38; EIF4A3; RPL36; RPS28; UBA52; RPS19; RPL18; RPL13A; RPS11
R-HSA-975957	Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)	5.39	0.00e+00	0.00e+00	40/105	RPL11; RPS27; RPS27A; RPL31; RPL14; RPL24; RPL22L1; RPL35A; RPL9; RPL34; RPL37; RPS14; RPS10; RPS4X; RPL39; RPL10; RPL30; RPLP2; RPL27A; RPS3; RPS25; MAGOHB; RPL21; RPS29; RPLP1; RPS15A; RPL13; RPL26; RPL23A; RPL23; RPL27; RPL38; EIF4A3; RPL36; RPS28; UBA52; RPS19; RPL18; RPL13A; RPS11
R-HSA-72706	GTP hydrolysis and joining of the 60S ribosomal subunit	5.34	0.00e+00	0.00e+00	40/106	RPL11; RPS27; RPS27A; RPL31; RPL14; RPL24; RPL22L1; RPL35A; RPL9; RPL34; RPL37; RPS14; RPS10; EIF1AX; RPS4X; RPL39; RPL10; RPL30; EIF3E; RPLP2; RPL27A; RPS3; RPS25; RPL21; RPS29; RPLP1; RPS15A; RPL13; RPL26; RPL23A; RPL23; RPL27; RPL38; RPL36; RPS28; UBA52; RPS19; RPL18; RPL13A; RPS11
R-HSA-157579	Telomere Maintenance	5.30	1.96e-05	3.26e-04	9/24	HIST2H2AC; H2AFZ; NHP2; HIST1H4C; RPA3; POLD2; H2AFV; RFC2; PCNA
R-HSA-5696397	Gap-filling DNA repair synthesis and ligation in GG-NER	5.30	5.15e-04	5.66e-03	6/16	RPS27A; RPA3; POLD2; RFC2; PCNA; UBA52
R-HSA-1799339	SRP-dependent cotranslational protein targeting to membrane	5.20	0.00e+00	0.00e+00	39/106	RPL11; RPS27; SRP9; RPS27A; RPL31; RPL14; RPL24; RPL22L1; RPL35A; RPL9; RPL34; RPL37; RPS14; RPS10; RPS4X; RPL39; RPL10; RPL30; RPLP2; RPL27A; RPS3; RPS25; RPL21; RPS29; RPLP1; RPS15A; RPL13; RPL26; RPL23A; RPL23; RPL27; RPL38; RPL36; RPS28; UBA52; RPS19; RPL18; RPL13A; RPS11
R-HSA-5651801	PCNA-Dependent Long Patch Base Excision Repair	5.14	5.41e-03	3.33e-02	4/11	RPA3; POLD2; RFC2; PCNA
R-HSA-3371568	Attenuation phase	5.14	5.41e-03	3.33e-02	4/11	HSP90AB1; HSPA8; PTGES3; HSP90AA1
R-HSA-2995383	Initiation of Nuclear Envelope Reformation	5.14	5.41e-03	3.33e-02	4/11	LMNB1; BANF1; TMPO; VRK1
R-HSA-2995410	Nuclear Envelope Reassembly	5.14	5.41e-03	3.33e-02	4/11	LMNB1; BANF1; TMPO; VRK1
R-HSA-2025928	Calcineurin activates NFAT	5.14	5.41e-03	3.33e-02	4/11	CALM2; PPIA; CALM1; CALM3
R-HSA-72613	Eukaryotic Translation Initiation	5.05	0.00e+00	0.00e+00	40/112	RPL11; RPS27; RPS27A; RPL31; RPL14; RPL24; RPL22L1; RPL35A; RPL9; RPL34; RPL37; RPS14; RPS10; EIF1AX; RPS4X; RPL39; RPL10; RPL30; EIF3E; RPLP2; RPL27A; RPS3; RPS25; RPL21; RPS29; RPLP1; RPS15A; RPL13; RPL26; RPL23A; RPL23; RPL27; RPL38; RPL36; RPS28; UBA52; RPS19; RPL18; RPL13A; RPS11
R-HSA-72737	Cap-dependent Translation Initiation	5.05	0.00e+00	0.00e+00	40/112	RPL11; RPS27; RPS27A; RPL31; RPL14; RPL24; RPL22L1; RPL35A; RPL9; RPL34; RPL37; RPS14; RPS10; EIF1AX; RPS4X; RPL39; RPL10; RPL30; EIF3E; RPLP2; RPL27A; RPS3; RPS25; RPL21; RPS29; RPLP1; RPS15A; RPL13; RPL26; RPL23A; RPL23; RPL27; RPL38; RPL36; RPS28; UBA52; RPS19; RPL18; RPL13A; RPS11
R-HSA-5627123	RHO GTPases activate PAKs	5.05	2.00e-03	1.48e-02	5/14	CALM2; FLNA; MYL6; CALM1; CALM3
R-HSA-5655862	Translesion synthesis by POLK	5.05	2.00e-03	1.48e-02	5/14	RPS27A; RPA3; RFC2; PCNA; UBA52
R-HSA-180786	Extension of Telomeres	5.05	2.00e-03	1.48e-02	5/14	NHP2; RPA3; POLD2; RFC2; PCNA
R-HSA-5339562	Uptake and actions of bacterial toxins	4.99	7.50e-04	7.39e-03	6/17	CALM2; HSP90AB1; CALM1; HSP90AA1; EEF2; CALM3
R-HSA-5625740	RHO GTPases activate PKNs	4.88	1.58e-05	2.98e-04	10/29	HIST2H2AC; H3F3A; YWHAQ; H2AFZ; HIST1H4C; H2AFV; MYL6; YWHAE; H3F3B; YWHAH
R-HSA-168273	Influenza Viral RNA Transcription and Replication	4.76	0.00e+00	0.00e+00	40/119	RPL11; RPS27; RPS27A; RPL31; RPL14; RPL24; RPL22L1; RPL35A; RPL9; RPL34; RPL37; RPS14; RPS10; RPS4X; RPL39; RPL10; RPL30; RPLP2; POLR2L; RPL27A; RPS3; RPS25; RPL21; RPS29; HSP90AA1; RPLP1; RPS15A; RPL13; RPL26; RPL23A; RPL23; RPL27; RPL38; RPL36; RPS28; UBA52; RPS19; RPL18; RPL13A; RPS11
R-HSA-110314	Recognition of DNA damage by PCNA-containing replication complex	4.72	4.00e-04	4.50e-03	7/21	USP1; RPS27A; RPA3; POLD2; RFC2; PCNA; UBA52
R-HSA-445355	Smooth Muscle Contraction	4.72	1.06e-03	9.56e-03	6/18	CALM2; MYL6; CALM1; ANXA2; TPM4; CALM3
R-HSA-110320	Translesion Synthesis by POLH	4.72	2.83e-03	1.99e-02	5/15	RPS27A; RPA3; RFC2; PCNA; UBA52
R-HSA-70263	Gluconeogenesis	4.72	7.67e-03	4.47e-02	4/12	ENO1; PGK1; PGAM1; TPI1
R-HSA-168255	Influenza Life Cycle	4.64	0.00e+00	0.00e+00	42/128	RPL11; RPS27; RPS27A; RPL31; RPL14; RPL24; RPL22L1; RPL35A; RPL9; RPL34; RPL37; RPS14; RPS10; RPS4X; RPL39; RPL10; RPL30; RPLP2; POLR2L; RPL27A; RPS3; RPS25; RAN; RPL21; RPS29; HSP90AA1; RPLP1; RPS15A; RPL13; RPL26; RPL23A; RPL23; RPL27; RPL38; RPL36; RPS28; CALR; UBA52; RPS19; RPL18; RPL13A; RPS11
R-HSA-1500620	Meiosis	4.58	1.18e-05	2.38e-04	11/34	HIST2H2AC; H3F3A; H2AFZ; LMNB1; HIST1H4C; RPA3; H2AFV; SMC1A; RAD21; CDK4; H3F3B
R-HSA-8950505	Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation	4.56	3.08e-05	4.77e-04	10/31	HNRNPDL; LMNB1; HNRNPA2B1; PPIA; CFL1; LCP1; PSME2; ANXA2; SNRPA1; MIF
R-HSA-2559586	DNA Damage/Telomere Stress Induced Senescence	4.55	8.03e-05	1.06e-03	9/28	HIST2H2AC; H2AFZ; LMNB1; HIST1H1C; HIST1H4C; HIST1H1E; HIST1H1D; HIST1H1B; H2AFV
R-HSA-5250924	B-WICH complex positively regulates rRNA expression	4.55	8.03e-05	1.06e-03	9/28	HIST2H2AC; H3F3A; H2AFZ; DEK; HIST1H4C; ACTB; H2AFV; POLR2L; H3F3B
R-HSA-1221632	Meiotic synapsis	4.50	5.52e-04	5.91e-03	7/22	HIST2H2AC; H2AFZ; LMNB1; HIST1H4C; H2AFV; SMC1A; RAD21
R-HSA-5656169	Termination of translesion DNA synthesis	4.50	5.52e-04	5.91e-03	7/22	RPS27A; RPA3; POLD2; RFC2; KIAA0101; PCNA; UBA52
R-HSA-606279	Deposition of new CENPA-containing nucleosomes at the centromere	4.47	1.46e-03	1.17e-02	6/19	HIST2H2AC; H2AFZ; HIST1H4C; H2AFV; STRA13; CENPM
R-HSA-774815	Nucleosome assembly	4.47	1.46e-03	1.17e-02	6/19	HIST2H2AC; H2AFZ; HIST1H4C; H2AFV; STRA13; CENPM
R-HSA-168254	Influenza Infection	4.44	0.00e+00	0.00e+00	43/137	RPL11; RPS27; RPS27A; RPL31; RPL14; RPL24; RPL22L1; RPL35A; RPL9; RPL34; RPL37; RPS14; RPS10; RPS4X; RPL39; RPL10; RPL30; RPLP2; POLR2L; RPL27A; RPS3; RPS25; RAN; RPL21; RPS29; HSP90AA1; RPLP1; RPS15A; RPL13; RPL26; RPL23A; RPL23; RPL27; KPNA2; RPL38; RPL36; RPS28; CALR; UBA52; RPS19; RPL18; RPL13A; RPS11
R-HSA-6783310	Fanconi Anemia Pathway	4.42	3.88e-03	2.57e-02	5/16	USP1; RPS27A; RPA3; STRA13; UBA52
R-HSA-8982491	Glycogen metabolism	4.42	3.88e-03	2.57e-02	5/16	CALM2; RPS27A; CALM1; UBA52; CALM3
R-HSA-9010553	Regulation of expression of SLITs and ROBOs	4.33	0.00e+00	0.00e+00	45/147	RPL11; RPS27; RPS27A; RPL31; RPL14; RPL24; RPL22L1; RPL35A; RPL9; RPL34; RPL37; RPS14; RPS10; RPS4X; RPL39; RPL10; RPL30; RPLP2; RPL27A; PSMC3; RPS3; RPS25; MAGOHB; RPL21; PSME2; RPS29; RPLP1; TCEB2; RPS15A; RPL13; RPL26; RPL23A; PSMB3; RPL23; RPL27; RPL38; EIF4A3; PSMA7; RPL36; RPS28; UBA52; RPS19; RPL18; RPL13A; RPS11
R-HSA-73886	Chromosome Maintenance	4.32	2.19e-05	3.51e-04	11/36	HIST2H2AC; H2AFZ; NHP2; HIST1H4C; RPA3; POLD2; H2AFV; RFC2; STRA13; PCNA; CENPM
R-HSA-1912408	Pre-NOTCH Transcription and Translation	4.31	7.46e-04	7.39e-03	7/23	HIST2H2AC; H3F3A; H2AFZ; HIST1H4C; H2AFV; TFDP1; H3F3B
R-HSA-427389	ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression	4.24	1.96e-03	1.48e-02	6/20	HIST2H2AC; H3F3A; H2AFZ; HIST1H4C; H2AFV; H3F3B
R-HSA-389958	Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding	4.24	1.96e-03	1.48e-02	6/20	CCT5; ACTB; TUBB4B; TUBA1B; TUBA1C; PFDN5
R-HSA-1474165	Reproduction	4.21	2.92e-05	4.60e-04	11/37	HIST2H2AC; H3F3A; H2AFZ; LMNB1; HIST1H4C; RPA3; H2AFV; SMC1A; RAD21; CDK4; H3F3B
R-HSA-163210	Formation of ATP by chemiosmotic coupling	4.16	5.19e-03	3.33e-02	5/17	ATP5G3; ATP5J2; ATP5G1; ATP5J; MT-ATP6
R-HSA-72695	Formation of the ternary complex, and subsequently, the 43S complex	4.13	2.99e-06	6.65e-05	14/48	RPS27; RPS27A; RPS14; RPS10; EIF1AX; RPS4X; EIF3E; RPS3; RPS25; RPS29; RPS15A; RPS28; RPS19; RPS11
R-HSA-376176	Signaling by ROBO receptors	3.98	0.00e+00	0.00e+00	47/167	RPL11; RPS27; RPS27A; RPL31; RPL14; RPL24; RPL22L1; RPL35A; RPL9; RPL34; RPL37; RPS14; RPS10; RPS4X; RPL39; RPL10; RPL30; RPLP2; RPL27A; PSMC3; RPS3; RPS25; MAGOHB; RPL21; PSME2; RPS29; EVL; RPLP1; TCEB2; RPS15A; RPL13; PFN1; RPL26; RPL23A; PSMB3; RPL23; RPL27; RPL38; EIF4A3; PSMA7; RPL36; RPS28; UBA52; RPS19; RPL18; RPL13A; RPS11
R-HSA-977225	Amyloid fiber formation	3.96	1.29e-03	1.10e-02	7/25	HIST2H2AC; H3F3A; RPS27A; H2AFZ; HIST1H4C; H3F3B; UBA52
R-HSA-9020591	Interleukin-12 signaling	3.93	1.29e-04	1.55e-03	10/36	HNRNPDL; LMNB1; HNRNPA2B1; PPIA; CFL1; LCP1; PSME2; ANXA2; SNRPA1; MIF
R-HSA-2559582	Senescence-Associated Secretory Phenotype (SASP)	3.89	6.52e-05	9.41e-04	11/40	HIST2H2AC; H3F3A; RPS27A; H2AFZ; HIST1H4C; H2AFV; CDK4; H3F3B; ANAPC11; UBE2C; UBA52
R-HSA-6791226	Major pathway of rRNA processing in the nucleolus and cytosol	3.75	3.18e-14	1.15e-12	40/151	RPL11; EBNA1BP2; RPS27; RPS27A; RPL31; NCL; RPL14; RPL24; RPL22L1; RPL35A; RPL9; RPL34; RPL37; RPS14; RPS10; RPS4X; RPL39; RPL10; RPL30; RPLP2; RPL27A; RPS3; RPS25; RPL21; RPS29; RPLP1; RPS15A; RPL13; RPL26; RPL23A; RPL23; RPL27; RPL38; RPL36; RPS28; UBA52; RPS19; RPL18; RPL13A; RPS11
R-HSA-2672351	Stimuli-sensing channels	3.72	8.68e-03	4.85e-02	5/19	CALM2; RPS27A; CALM1; UBA52; CALM3
R-HSA-389957	Prefoldin mediated transfer of substrate to CCT/TriC	3.72	8.68e-03	4.85e-02	5/19	CCT5; ACTB; TUBB4B; TUBA1C; PFDN5
R-HSA-179409	APC-Cdc20 mediated degradation of Nek2A	3.72	8.68e-03	4.85e-02	5/19	RPS27A; MAD2L1; ANAPC11; UBE2C; UBA52
R-HSA-2559580	Oxidative Stress Induced Senescence	3.69	5.36e-05	7.88e-04	12/46	HIST2H2AC; H3F3A; RPS27A; H2AFZ; HIST1H4C; H2AFV; EZH2; TXN; CDK4; TFDP1; H3F3B; UBA52
R-HSA-3299685	Detoxification of Reactive Oxygen Species	3.69	4.26e-03	2.80e-02	6/23	PRDX1; ATOX1; CYCS; TXN; GSTP1; PRDX2
R-HSA-8868773	rRNA processing in the nucleus and cytosol	3.62	5.04e-14	1.75e-12	41/160	RPL11; EBNA1BP2; RPS27; RPS27A; RPL31; NCL; RPL14; RPL24; RPL22L1; RPL35A; RPL9; RPL34; RPL37; RPS14; NHP2; RPS10; RPS4X; RPL39; RPL10; RPL30; RPLP2; RPL27A; RPS3; RPS25; RPL21; RPS29; RPLP1; RPS15A; RPL13; RPL26; RPL23A; RPL23; RPL27; RPL38; RPL36; RPS28; UBA52; RPS19; RPL18; RPL13A; RPS11
R-HSA-72649	Translation initiation complex formation	3.60	1.72e-05	3.11e-04	14/55	RPS27; RPS27A; RPS14; RPS10; EIF1AX; RPS4X; EIF3E; RPS3; RPS25; RPS29; RPS15A; RPS28; RPS19; RPS11
R-HSA-72702	Ribosomal scanning and start codon recognition	3.60	1.72e-05	3.11e-04	14/55	RPS27; RPS27A; RPS14; RPS10; EIF1AX; RPS4X; EIF3E; RPS3; RPS25; RPS29; RPS15A; RPS28; RPS19; RPS11
R-HSA-72662	Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S	3.54	2.15e-05	3.51e-04	14/56	RPS27; RPS27A; RPS14; RPS10; EIF1AX; RPS4X; EIF3E; RPS3; RPS25; RPS29; RPS15A; RPS28; RPS19; RPS11
R-HSA-73777	RNA Polymerase I Chain Elongation	3.54	2.65e-03	1.89e-02	7/28	HIST2H2AC; H3F3A; H2AFZ; HIST1H4C; H2AFV; POLR2L; H3F3B
R-HSA-110313	Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template	3.54	2.65e-03	1.89e-02	7/28	RPS27A; RPA3; POLD2; RFC2; KIAA0101; PCNA; UBA52
R-HSA-8936459	RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function	3.54	5.36e-03	3.33e-02	6/24	HIST2H2AC; H3F3A; H2AFZ; HIST1H4C; H2AFV; H3F3B
R-HSA-72312	rRNA processing	3.49	1.96e-13	6.53e-12	41/166	RPL11; EBNA1BP2; RPS27; RPS27A; RPL31; NCL; RPL14; RPL24; RPL22L1; RPL35A; RPL9; RPL34; RPL37; RPS14; NHP2; RPS10; RPS4X; RPL39; RPL10; RPL30; RPLP2; RPL27A; RPS3; RPS25; RPL21; RPS29; RPLP1; RPS15A; RPL13; RPL26; RPL23A; RPL23; RPL27; RPL38; RPL36; RPS28; UBA52; RPS19; RPL18; RPL13A; RPS11
R-HSA-195258	RHO GTPase Effectors	3.46	7.71e-11	2.31e-09	33/135	NUDC; HIST2H2AC; RPS27; ARPC5; CENPF; H3F3A; YWHAQ; CALM2; ACTR3; ARPC2; H2AFZ; MAD2L1; HIST1H4C; ACTB; H2AFV; ARPC1B; FLNA; TUBB4B; CFL1; TUBA1B; TUBA1C; MYL6; CALM1; EVL; YWHAE; PFN1; SKA2; H3F3B; ACTG1; NDC80; CALM3; YWHAH; CENPM
R-HSA-2029482	Regulation of actin dynamics for phagocytic cup formation	3.44	8.22e-04	8.00e-03	9/37	ARPC5; ACTR3; ARPC2; HSP90AB1; ACTB; ARPC1B; CFL1; HSP90AA1; ACTG1
R-HSA-1912422	Pre-NOTCH Expression and Processing	3.41	3.29e-03	2.30e-02	7/29	HIST2H2AC; H3F3A; H2AFZ; HIST1H4C; H2AFV; TFDP1; H3F3B
R-HSA-5663213	RHO GTPases Activate WASPs and WAVEs	3.40	6.64e-03	3.97e-02	6/25	ARPC5; ACTR3; ARPC2; ACTB; ARPC1B; ACTG1
R-HSA-422475	Axon guidance	3.38	0.00e+00	0.00e+00	61/255	RPL11; RPS27; ARPC5; RPS27A; RPL31; ACTR3; ARPC2; RPL14; RPL24; RPL22L1; RPL35A; RPL9; RPL34; RPL37; RPS14; RPS10; HSP90AB1; ACTB; ARPC1B; RPS4X; RPL39; RPL10; RPL30; TUBB4B; RPLP2; RPL27A; PSMC3; CFL1; RPS3; RPS25; HSPA8; MAGOHB; TUBA1B; TUBA1C; MYL6; RPL21; PSME2; RPS29; EVL; HSP90AA1; RPLP1; TCEB2; RPS15A; RPL13; PFN1; RPL26; RPL23A; PSMB3; RPL23; RPL27; RPL38; EIF4A3; ACTG1; PSMA7; RPL36; RPS28; UBA52; RPS19; RPL18; RPL13A; RPS11
R-HSA-1445148	Translocation of SLC2A4 (GLUT4) to the plasma membrane	3.38	2.57e-04	3.01e-03	11/46	YWHAQ; CALM2; ACTB; TUBB4B; TUBA1B; TUBA1C; CALM1; YWHAE; ACTG1; CALM3; YWHAH
R-HSA-447115	Interleukin-12 family signaling	3.37	5.09e-04	5.66e-03	10/42	HNRNPDL; LMNB1; HNRNPA2B1; PPIA; CFL1; LCP1; PSME2; ANXA2; SNRPA1; MIF
R-HSA-201722	Formation of the beta-catenin:TCF transactivating complex	3.26	8.13e-03	4.67e-02	6/26	HIST2H2AC; H3F3A; H2AFZ; HIST1H4C; H2AFV; H3F3B
R-HSA-73893	DNA Damage Bypass	3.23	2.46e-03	1.80e-02	8/35	USP1; RPS27A; RPA3; POLD2; RFC2; KIAA0101; PCNA; UBA52
R-HSA-75153	Apoptotic execution phase	3.19	4.91e-03	3.20e-02	7/31	HMGB2; LMNB1; HIST1H1C; HIST1H1E; HIST1H1D; HIST1H1B; HMGB1
R-HSA-5250913	Positive epigenetic regulation of rRNA expression	3.18	1.50e-03	1.19e-02	9/40	HIST2H2AC; H3F3A; H2AFZ; DEK; HIST1H4C; ACTB; H2AFV; POLR2L; H3F3B
R-HSA-71291	Metabolism of amino acids and derivatives	3.14	7.54e-13	2.42e-11	45/203	RPL11; RPS27; ODC1; RPS27A; RPL31; RPL14; RPL24; RPL22L1; RPL35A; RPL9; RPL34; RPL37; RPS14; RPS10; SMS; RPS4X; RPL39; RPL10; RPL30; RPLP2; RPL27A; PSMC3; RPS3; RPS25; RPL21; PSME2; RPS29; RPLP1; RPS15A; RPL13; RPL26; RPL23A; PSMB3; RPL23; RPL27; RPL38; PSMA7; OAZ1; RPL36; RPS28; UBA52; RPS19; RPL18; RPL13A; RPS11
R-HSA-5663220	RHO GTPases Activate Formins	3.09	1.06e-04	1.31e-03	14/64	NUDC; RPS27; CENPF; MAD2L1; ACTB; TUBB4B; TUBA1B; TUBA1C; EVL; PFN1; SKA2; ACTG1; NDC80; CENPM
R-HSA-68875	Mitotic Prophase	3.06	2.07e-04	2.46e-03	13/60	HIST2H2AC; H3F3A; SMC4; H2AFZ; LMNB1; HIST1H4C; H2AFV; SMC2; SET; BANF1; TMPO; VRK1; H3F3B
R-HSA-2682334	EPH-Ephrin signaling	3.06	3.56e-03	2.45e-02	8/37	ARPC5; ACTR3; ARPC2; ACTB; ARPC1B; CFL1; MYL6; ACTG1
R-HSA-2559583	Cellular Senescence	3.02	8.93e-06	1.84e-04	19/89	HIST2H2AC; H3F3A; RPS27A; H2AFZ; LMNB1; HIST1H1C; HIST1H4C; HIST1H1E; HIST1H1D; HIST1H1B; H2AFV; EZH2; TXN; CDK4; TFDP1; H3F3B; ANAPC11; UBE2C; UBA52
R-HSA-3371497	HSP90 chaperone cycle for steroid hormone receptors (SHR)	3.00	7.06e-03	4.17e-02	7/33	HSP90AB1; TUBB4B; HSPA8; TUBA1B; TUBA1C; PTGES3; HSP90AA1
R-HSA-427413	NoRC negatively regulates rRNA expression	2.90	5.02e-03	3.25e-02	8/39	HIST2H2AC; H3F3A; H2AFZ; HIST1H4C; H2AFV; POLR2L; H3F3B; DNMT1
R-HSA-2500257	Resolution of Sister Chromatid Cohesion	2.88	6.72e-04	6.94e-03	12/59	NUDC; RPS27; CENPF; MAD2L1; SMC1A; RAD21; TUBB4B; TUBA1B; TUBA1C; SKA2; NDC80; CENPM
R-HSA-2029480	Fcgamma receptor (FCGR) dependent phagocytosis	2.83	3.55e-03	2.45e-02	9/45	ARPC5; ACTR3; ARPC2; HSP90AB1; ACTB; ARPC1B; CFL1; HSP90AA1; ACTG1
R-HSA-5663205	Infectious disease	2.81	1.95e-14	7.37e-13	59/297	RPL11; RPS27; CALM2; RPS27A; RPL31; RPL14; RPL24; RPL22L1; RPL35A; RPL9; RPL34; RPL37; RPS14; RPS10; HSP90AB1; PPIA; RPS4X; SLC25A5; RPL39; RPL10; RPL30; RPLP2; POLR2L; RPL27A; PSMC3; SSRP1; BANF1; RPS3; RPS25; RAN; RPL21; SUPT16H; PSME2; RPS29; CALM1; HSP90AA1; RPLP1; TCEB2; RPS15A; RPL13; RPL26; RPL23A; PSMB3; RPL23; RPL27; KPNA2; RPL38; PSMA7; EEF2; RPL36; RPS28; CALR; UBA52; RPS19; CALM3; RPL18; RPL13A; RPS11; RANBP1
R-HSA-9018519	Estrogen-dependent gene expression	2.79	5.59e-04	5.91e-03	13/66	HIST2H2AC; H3F3A; H2AFZ; HIST1H4C; HSP90AB1; H2AFV; SMC1A; RAD21; POLR2L; PTGES3; HSP90AA1; KPNA2; H3F3B
R-HSA-1266738	Developmental Biology	2.78	0.00e+00	0.00e+00	70/356	RPL11; HIST2H2AC; RPS27; ARPC5; H3F3A; RPS27A; RPL31; ACTR3; ARPC2; RPL14; RPL24; RPL22L1; RPL35A; RPL9; H2AFZ; RPL34; RPL37; RPS14; HIST1H4C; RPS10; HSP90AB1; ACTB; H2AFV; ARPC1B; EZH2; RPS4X; RPL39; RPL10; RPL30; TUBB4B; RPLP2; POLR2L; RPL27A; PSMC3; CFL1; RPS3; RPS25; HSPA8; MAGOHB; TUBA1B; TUBA1C; MYL6; CDK4; RPL21; PSME2; RPS29; EVL; HSP90AA1; RPLP1; TCEB2; RPS15A; RPL13; PFN1; RPL26; RPL23A; PSMB3; RPL23; RPL27; RPL38; H3F3B; EIF4A3; ACTG1; PSMA7; RPL36; RPS28; UBA52; RPS19; RPL18; RPL13A; RPS11
R-HSA-8852276	The role of GTSE1 in G2/M progression after G2 checkpoint	2.78	1.52e-03	1.20e-02	11/56	RPS27A; HSP90AB1; TUBB4B; PSMC3; TUBA1B; TUBA1C; PSME2; HSP90AA1; PSMB3; PSMA7; UBA52
R-HSA-5250941	Negative epigenetic regulation of rRNA expression	2.76	6.90e-03	4.10e-02	8/41	HIST2H2AC; H3F3A; H2AFZ; HIST1H4C; H2AFV; POLR2L; H3F3B; DNMT1
R-HSA-2555396	Mitotic Metaphase and Anaphase	2.74	2.18e-06	4.98e-05	25/129	NUDC; RPS27; CENPF; RPS27A; MAD2L1; LMNB1; PTTG1; SMC1A; RAD21; TUBB4B; PSMC3; BANF1; TUBA1B; TUBA1C; TMPO; PSME2; VRK1; PSMB3; SKA2; ANAPC11; NDC80; UBE2C; PSMA7; UBA52; CENPM
R-HSA-68882	Mitotic Anaphase	2.74	2.18e-06	4.98e-05	25/129	NUDC; RPS27; CENPF; RPS27A; MAD2L1; LMNB1; PTTG1; SMC1A; RAD21; TUBB4B; PSMC3; BANF1; TUBA1B; TUBA1C; TMPO; PSME2; VRK1; PSMB3; SKA2; ANAPC11; NDC80; UBE2C; PSMA7; UBA52; CENPM
R-HSA-194315	Signaling by Rho GTPases	2.73	2.96e-08	7.77e-07	34/176	NUDC; HIST2H2AC; RPS27; ARPC5; CENPF; H3F3A; YWHAQ; CALM2; ACTR3; ARPC2; H2AFZ; MAD2L1; HIST1H4C; ACTB; H2AFV; ARPC1B; FLNA; TUBB4B; CFL1; ARHGDIB; TUBA1B; TUBA1C; MYL6; CALM1; EVL; YWHAE; PFN1; SKA2; H3F3B; ACTG1; NDC80; CALM3; YWHAH; CENPM
R-HSA-8939236	RUNX1 regulates transcription of genes involved in differentiation of HSCs	2.69	1.24e-03	1.07e-02	12/63	HIST2H2AC; H3F3A; RPS27A; H2AFZ; HIST1H4C; H2AFV; PSMC3; PSME2; PSMB3; H3F3B; PSMA7; UBA52
R-HSA-5578749	Transcriptional regulation by small RNAs	2.69	8.01e-03	4.63e-02	8/42	HIST2H2AC; H3F3A; H2AFZ; HIST1H4C; H2AFV; POLR2L; RAN; H3F3B
R-HSA-69206	G1/S Transition	2.65	3.73e-04	4.31e-03	15/80	CKS1B; RPS27A; DHFR; MCM3; RPA3; MCM7; PSMC3; CDK4; TFDP1; PSME2; PSMB3; TYMS; PCNA; PSMA7; UBA52
R-HSA-5628897	TP53 Regulates Metabolic Genes	2.65	1.43e-03	1.17e-02	12/64	PRDX1; YWHAQ; CYCS; COX7B; TXN; COX8A; COX6A1; YWHAE; PRDX2; YWHAH; MT-CO1; MT-CO3
R-HSA-8939211	ESR-mediated signaling	2.63	1.01e-03	9.17e-03	13/70	HIST2H2AC; H3F3A; H2AFZ; HIST1H4C; HSP90AB1; H2AFV; SMC1A; RAD21; POLR2L; PTGES3; HSP90AA1; KPNA2; H3F3B
R-HSA-69278	Cell Cycle, Mitotic	2.60	3.57e-11	1.11e-09	51/277	NUDC; HIST2H2AC; RPS27; CKS1B; CENPF; H3F3A; RPS27A; SMC4; H2AFZ; MAD2L1; DHFR; LMNB1; PTTG1; HIST1H4C; TUBB; HSP90AB1; MCM3; RPA3; POLD2; H2AFV; RFC2; MCM7; SMC1A; RAD21; SMC2; SET; TUBB4B; PSMC3; BANF1; TUBA1B; TUBA1C; CDK4; TMPO; TFDP1; PSME2; VRK1; HSP90AA1; YWHAE; PSMB3; TOP2A; SKA2; H3F3B; ANAPC11; TYMS; NDC80; PCNA; TPX2; UBE2C; PSMA7; UBA52; CENPM
R-HSA-69242	S Phase	2.58	8.96e-05	1.13e-03	19/104	CKS1B; RPS27A; MCM3; RPA3; POLD2; RFC2; MCM7; SMC1A; RAD21; PSMC3; CDK4; TFDP1; PSME2; PSMB3; ANAPC11; PCNA; UBE2C; PSMA7; UBA52
R-HSA-983231	Factors involved in megakaryocyte development and platelet production	2.55	7.37e-03	4.32e-02	9/50	H3F3A; ACTB; TUBB4B; KIF20B; TUBA1B; TUBA1C; CBX5; KIF22; H3F3B
R-HSA-453279	Mitotic G1-G1/S phases	2.54	3.93e-04	4.49e-03	16/89	CKS1B; RPS27A; DHFR; MCM3; RPA3; MCM7; PSMC3; CDK4; TFDP1; PSME2; PSMB3; TOP2A; TYMS; PCNA; PSMA7; UBA52
R-HSA-69239	Synthesis of DNA	2.54	9.22e-04	8.50e-03	14/78	RPS27A; MCM3; RPA3; POLD2; RFC2; MCM7; PSMC3; PSME2; PSMB3; ANAPC11; PCNA; UBE2C; PSMA7; UBA52
R-HSA-212165	Epigenetic regulation of gene expression	2.50	2.47e-03	1.80e-02	12/68	HIST2H2AC; H3F3A; H2AFZ; DEK; HIST1H4C; ACTB; H2AFV; EZH2; PHF19; POLR2L; H3F3B; DNMT1
R-HSA-72165	mRNA Splicing - Minor Pathway	2.50	8.41e-03	4.80e-02	9/51	YBX1; SNRPE; SRSF7; SNRPG; POLR2L; SNRNP25; SRSF2; SNRPD1; SNRPB
R-HSA-69306	DNA Replication	2.48	1.19e-03	1.05e-02	14/80	RPS27A; MCM3; RPA3; POLD2; RFC2; MCM7; PSMC3; PSME2; PSMB3; ANAPC11; PCNA; UBE2C; PSMA7; UBA52
R-HSA-2467813	Separation of Sister Chromatids	2.48	7.35e-05	1.03e-03	21/120	NUDC; RPS27; CENPF; RPS27A; MAD2L1; PTTG1; SMC1A; RAD21; TUBB4B; PSMC3; TUBA1B; TUBA1C; PSME2; PSMB3; SKA2; ANAPC11; NDC80; UBE2C; PSMA7; UBA52; CENPM
R-HSA-109688	Cleavage of Growing Transcript in the Termination Region	2.44	6.61e-03	3.97e-02	10/58	SNRPE; SRSF7; SNRPG; SLBP; SRSF3; MAGOHB; SRSF2; EIF4A3; SNRPB; DDX39A
R-HSA-73856	RNA Polymerase II Transcription Termination	2.44	6.61e-03	3.97e-02	10/58	SNRPE; SRSF7; SNRPG; SLBP; SRSF3; MAGOHB; SRSF2; EIF4A3; SNRPB; DDX39A
R-HSA-1592230	Mitochondrial biogenesis	2.44	6.61e-03	3.97e-02	10/58	CALM2; ATP5G3; CYCS; ATP5J2; CALM1; IDH2; ATP5G1; CALM3; ATP5J; MT-ATP6
R-HSA-72766	Translation	2.42	1.10e-08	3.07e-07	44/257	RPL11; RPS27; SRP9; RPS27A; RPL31; RPL14; RPL24; RPL22L1; RPL35A; RPL9; RPL34; RPL37; RPS14; RPS10; EEF1A1; EIF1AX; RPS4X; RPL39; RPL10; RPL30; EIF3E; RPLP2; RPL27A; RPS3; RPS25; RPL21; RPS29; RPLP1; RPS15A; RPL13; RPL26; RPL23A; RPL23; RPL27; RPL38; MRPL12; EEF2; RPL36; RPS28; UBA52; RPS19; RPL18; RPL13A; RPS11
R-HSA-68886	M Phase	2.41	2.14e-07	5.45e-06	37/217	NUDC; HIST2H2AC; RPS27; CENPF; H3F3A; RPS27A; SMC4; H2AFZ; MAD2L1; LMNB1; PTTG1; HIST1H4C; TUBB; H2AFV; SMC1A; RAD21; SMC2; SET; TUBB4B; PSMC3; BANF1; TUBA1B; TUBA1C; TMPO; PSME2; VRK1; HSP90AA1; YWHAE; PSMB3; SKA2; H3F3B; ANAPC11; NDC80; UBE2C; PSMA7; UBA52; CENPM
R-HSA-1640170	Cell Cycle	2.40	9.60e-11	2.78e-09	56/330	NUDC; HIST2H2AC; RPS27; CKS1B; CENPF; H3F3A; YWHAQ; RPS27A; SMC4; WHSC1; H2AFZ; MAD2L1; DHFR; LMNB1; PTTG1; NHP2; HIST1H4C; TUBB; HSP90AB1; MCM3; RPA3; POLD2; H2AFV; RFC2; MCM7; SMC1A; RAD21; SMC2; SET; TUBB4B; PSMC3; BANF1; TUBA1B; TUBA1C; CDK4; TMPO; TFDP1; PSME2; VRK1; HSP90AA1; YWHAE; PSMB3; TOP2A; SKA2; H3F3B; ANAPC11; STRA13; TYMS; NDC80; PCNA; TPX2; UBE2C; PSMA7; UBA52; YWHAH; CENPM
R-HSA-9006931	Signaling by Nuclear Receptors	2.39	1.73e-03	1.34e-02	14/83	HIST2H2AC; H3F3A; H2AFZ; HIST1H4C; HSP90AB1; H2AFV; SMC1A; FABP5; RAD21; POLR2L; PTGES3; HSP90AA1; KPNA2; H3F3B
R-HSA-69481	G2/M Checkpoints	2.38	1.20e-03	1.05e-02	15/89	YWHAQ; RPS27A; WHSC1; HIST1H4C; MCM3; RPA3; RFC2; MCM7; PSMC3; PSME2; YWHAE; PSMB3; PSMA7; UBA52; YWHAH
R-HSA-68877	Mitotic Prometaphase	2.33	7.34e-04	7.39e-03	17/103	NUDC; RPS27; CENPF; SMC4; MAD2L1; TUBB; SMC1A; RAD21; SMC2; TUBB4B; TUBA1B; TUBA1C; HSP90AA1; YWHAE; SKA2; NDC80; CENPM
R-HSA-163200	Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.	2.29	6.40e-04	6.68e-03	18/111	NDUFS5; ATP5G3; NDUFS6; UQCRQ; CYCS; ATP5J2; NDUFB2; COX7B; UQCRB; COX8A; COX6A1; ATP5G1; ATP5J; MT-ND2; MT-CO1; MT-ATP6; MT-CO3; MT-CYB
R-HSA-69620	Cell Cycle Checkpoints	2.23	1.24e-04	1.51e-03	24/152	NUDC; RPS27; CENPF; YWHAQ; RPS27A; WHSC1; MAD2L1; HIST1H4C; MCM3; RPA3; RFC2; MCM7; PSMC3; PSME2; YWHAE; PSMB3; SKA2; ANAPC11; NDC80; UBE2C; PSMA7; UBA52; YWHAH; CENPM
R-HSA-2262752	Cellular responses to stress	2.20	1.20e-06	2.88e-05	39/251	PRDX1; HIST2H2AC; H3F3A; RPS27A; H2AFZ; LMNB1; ATOX1; HIST1H1C; HIST1H4C; HIST1H1E; HIST1H1D; HIST1H1B; HSP90AB1; EEF1A1; RPA3; CYCS; H2AFV; EZH2; TXN; TUBB4B; PSMC3; GSTP1; HSPA8; TUBA1B; TUBA1C; PTGES3; CDK4; TFDP1; PSME2; HSP90AA1; TCEB2; YWHAE; PSMB3; H3F3B; ANAPC11; UBE2C; PSMA7; PRDX2; UBA52
R-HSA-109581	Apoptosis	2.20	1.09e-03	9.78e-03	18/116	YWHAQ; RPS27A; HMGB2; LMNB1; HIST1H1C; HIST1H1E; HIST1H1D; HIST1H1B; CYCS; PSMC3; HMGB1; TFDP1; PSME2; YWHAE; PSMB3; PSMA7; UBA52; YWHAH
R-HSA-5357801	Programmed Cell Death	2.18	1.21e-03	1.05e-02	18/117	YWHAQ; RPS27A; HMGB2; LMNB1; HIST1H1C; HIST1H1E; HIST1H1D; HIST1H1B; CYCS; PSMC3; HMGB1; TFDP1; PSME2; YWHAE; PSMB3; PSMA7; UBA52; YWHAH
R-HSA-1428517	The citric acid (TCA) cycle and respiratory electron transport	2.04	1.54e-03	1.20e-02	20/139	NDUFS5; ATP5G3; NDUFS6; UQCRQ; CYCS; ATP5J2; NDUFB2; COX7B; UQCRB; LDHA; COX8A; COX6A1; IDH2; ATP5G1; ATP5J; MT-ND2; MT-CO1; MT-ATP6; MT-CO3; MT-CYB

MEF2D : 32 significant Reactome pathways

GeneSet	description	enrichRatio	pValue	FDR	GeneRatio	geneSymbols
R-HSA-156902	Peptide chain elongation	24.00	0.00e+00	0.00e+00	17/84	RPS27; RPL31; RPS14; RPL30; RPL12; RPS25; RPS26; RPL41; RPS29; RPL36AL; RPL4; RPL38; RPS21; EEF2; RPL36; RPS28; RPL28
R-HSA-156842	Eukaryotic Translation Elongation	23.20	0.00e+00	0.00e+00	17/87	RPS27; RPL31; RPS14; RPL30; RPL12; RPS25; RPS26; RPL41; RPS29; RPL36AL; RPL4; RPL38; RPS21; EEF2; RPL36; RPS28; RPL28
R-HSA-975956	Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)	22.90	0.00e+00	0.00e+00	17/88	RPS27; RPL31; RPS14; RPL30; PABPC1; RPL12; RPS25; RPS26; RPL41; RPS29; RPL36AL; RPL4; RPL38; RPS21; RPL36; RPS28; RPL28
R-HSA-192823	Viral mRNA Translation	22.60	0.00e+00	0.00e+00	16/84	RPS27; RPL31; RPS14; RPL30; RPL12; RPS25; RPS26; RPL41; RPS29; RPL36AL; RPL4; RPL38; RPS21; RPL36; RPS28; RPL28
R-HSA-2408557	Selenocysteine synthesis	22.30	0.00e+00	0.00e+00	16/85	RPS27; RPL31; RPS14; RPL30; RPL12; RPS25; RPS26; RPL41; RPS29; RPL36AL; RPL4; RPL38; RPS21; RPL36; RPS28; RPL28
R-HSA-72764	Eukaryotic Translation Termination	21.80	0.00e+00	0.00e+00	16/87	RPS27; RPL31; RPS14; RPL30; RPL12; RPS25; RPS26; RPL41; RPS29; RPL36AL; RPL4; RPL38; RPS21; RPL36; RPS28; RPL28
R-HSA-72689	Formation of a pool of free 40S subunits	20.00	0.00e+00	0.00e+00	16/95	RPS27; RPL31; RPS14; RPL30; RPL12; RPS25; RPS26; RPL41; RPS29; RPL36AL; RPL4; RPL38; RPS21; RPL36; RPS28; RPL28
R-HSA-156827	L13a-mediated translational silencing of Ceruloplasmin expression	19.20	0.00e+00	0.00e+00	17/105	RPS27; RPL31; RPS14; RPL30; PABPC1; RPL12; RPS25; RPS26; RPL41; RPS29; RPL36AL; RPL4; RPL38; RPS21; RPL36; RPS28; RPL28
R-HSA-927802	Nonsense-Mediated Decay (NMD)	19.20	0.00e+00	0.00e+00	17/105	RPS27; RPL31; RPS14; RPL30; PABPC1; RPL12; RPS25; RPS26; RPL41; RPS29; RPL36AL; RPL4; RPL38; RPS21; RPL36; RPS28; RPL28
R-HSA-975957	Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)	19.20	0.00e+00	0.00e+00	17/105	RPS27; RPL31; RPS14; RPL30; PABPC1; RPL12; RPS25; RPS26; RPL41; RPS29; RPL36AL; RPL4; RPL38; RPS21; RPL36; RPS28; RPL28
R-HSA-2408522	Selenoamino acid metabolism	19.20	0.00e+00	0.00e+00	16/99	RPS27; RPL31; RPS14; RPL30; RPL12; RPS25; RPS26; RPL41; RPS29; RPL36AL; RPL4; RPL38; RPS21; RPL36; RPS28; RPL28
R-HSA-72613	Eukaryotic Translation Initiation	18.00	0.00e+00	0.00e+00	17/112	RPS27; RPL31; RPS14; RPL30; PABPC1; RPL12; RPS25; RPS26; RPL41; RPS29; RPL36AL; RPL4; RPL38; RPS21; RPL36; RPS28; RPL28
R-HSA-72737	Cap-dependent Translation Initiation	18.00	0.00e+00	0.00e+00	17/112	RPS27; RPL31; RPS14; RPL30; PABPC1; RPL12; RPS25; RPS26; RPL41; RPS29; RPL36AL; RPL4; RPL38; RPS21; RPL36; RPS28; RPL28
R-HSA-72706	GTP hydrolysis and joining of the 60S ribosomal subunit	17.90	0.00e+00	0.00e+00	16/106	RPS27; RPL31; RPS14; RPL30; RPL12; RPS25; RPS26; RPL41; RPS29; RPL36AL; RPL4; RPL38; RPS21; RPL36; RPS28; RPL28
R-HSA-1799339	SRP-dependent cotranslational protein targeting to membrane	17.90	0.00e+00	0.00e+00	16/106	RPS27; RPL31; RPS14; RPL30; RPL12; RPS25; RPS26; RPL41; RPS29; RPL36AL; RPL4; RPL38; RPS21; RPL36; RPS28; RPL28
R-HSA-72695	Formation of the ternary complex, and subsequently, the 43S complex	17.30	8.51e-08	2.38e-06	7/48	RPS27; RPS14; RPS25; RPS26; RPS29; RPS21; RPS28
R-HSA-72649	Translation initiation complex formation	17.30	8.95e-09	2.68e-07	8/55	RPS27; RPS14; PABPC1; RPS25; RPS26; RPS29; RPS21; RPS28
R-HSA-72662	Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S	16.90	1.04e-08	3.00e-07	8/56	RPS27; RPS14; PABPC1; RPS25; RPS26; RPS29; RPS21; RPS28
R-HSA-168273	Influenza Viral RNA Transcription and Replication	16.00	1.11e-16	5.66e-15	16/119	RPS27; RPL31; RPS14; RPL30; RPL12; RPS25; RPS26; RPL41; RPS29; RPL36AL; RPL4; RPL38; RPS21; RPL36; RPS28; RPL28
R-HSA-72702	Ribosomal scanning and start codon recognition	15.10	2.25e-07	6.11e-06	7/55	RPS27; RPS14; RPS25; RPS26; RPS29; RPS21; RPS28
R-HSA-168255	Influenza Life Cycle	14.80	3.33e-16	1.60e-14	16/128	RPS27; RPL31; RPS14; RPL30; RPL12; RPS25; RPS26; RPL41; RPS29; RPL36AL; RPL4; RPL38; RPS21; RPL36; RPS28; RPL28
R-HSA-168254	Influenza Infection	13.90	1.11e-15	4.81e-14	16/137	RPS27; RPL31; RPS14; RPL30; RPL12; RPS25; RPS26; RPL41; RPS29; RPL36AL; RPL4; RPL38; RPS21; RPL36; RPS28; RPL28
R-HSA-9010553	Regulation of expression of SLITs and ROBOs	13.70	1.11e-16	5.66e-15	17/147	RPS27; RPL31; RPS14; RPL30; PABPC1; RPL12; RPS25; RPS26; RPL41; RPS29; RPL36AL; RPL4; RPL38; RPS21; RPL36; RPS28; RPL28
R-HSA-6791226	Major pathway of rRNA processing in the nucleolus and cytosol	12.60	5.22e-15	2.15e-13	16/151	RPS27; RPL31; RPS14; RPL30; RPL12; RPS25; RPS26; RPL41; RPS29; RPL36AL; RPL4; RPL38; RPS21; RPL36; RPS28; RPL28
R-HSA-376176	Signaling by ROBO receptors	12.10	9.99e-16	4.56e-14	17/167	RPS27; RPL31; RPS14; RPL30; PABPC1; RPL12; RPS25; RPS26; RPL41; RPS29; RPL36AL; RPL4; RPL38; RPS21; RPL36; RPS28; RPL28
R-HSA-8868773	rRNA processing in the nucleus and cytosol	11.90	1.33e-14	5.25e-13	16/160	RPS27; RPL31; RPS14; RPL30; RPL12; RPS25; RPS26; RPL41; RPS29; RPL36AL; RPL4; RPL38; RPS21; RPL36; RPS28; RPL28
R-HSA-72312	rRNA processing	11.40	2.42e-14	9.12e-13	16/166	RPS27; RPL31; RPS14; RPL30; RPL12; RPS25; RPS26; RPL41; RPS29; RPL36AL; RPL4; RPL38; RPS21; RPL36; RPS28; RPL28
R-HSA-71291	Metabolism of amino acids and derivatives	9.35	5.99e-13	2.08e-11	16/203	RPS27; RPL31; RPS14; RPL30; RPL12; RPS25; RPS26; RPL41; RPS29; RPL36AL; RPL4; RPL38; RPS21; RPL36; RPS28; RPL28
R-HSA-72766	Translation	8.31	8.04e-14	2.90e-12	18/257	RPS27; RPL31; RPS14; RPL30; PABPC1; RPL12; RPS25; RPS26; RPL41; RPS29; RPL36AL; RPL4; RPL38; RPS21; EEF2; RPL36; RPS28; RPL28
R-HSA-422475	Axon guidance	7.91	1.30e-12	4.33e-11	17/255	RPS27; RPL31; RPS14; RPL30; PABPC1; RPL12; RPS25; RPS26; RPL41; RPS29; RPL36AL; RPL4; RPL38; RPS21; RPL36; RPS28; RPL28
R-HSA-5663205	Infectious disease	6.79	1.59e-11	5.12e-10	17/297	RPS27; RPL31; RPS14; RPL30; RPL12; RPS25; RPS26; RPL41; RPS29; RPL36AL; RPL4; RPL38; RPS21; EEF2; RPL36; RPS28; RPL28
R-HSA-1266738	Developmental Biology	6.00	2.35e-11	7.27e-10	18/356	RPS27; H3F3A; RPL31; RPS14; RPL30; PABPC1; RPL12; RPS25; RPS26; RPL41; RPS29; RPL36AL; RPL4; RPL38; RPS21; RPL36; RPS28; RPL28

PDCD1 : 9 significant Reactome pathways

GeneSet	description	enrichRatio	pValue	FDR	GeneRatio	geneSymbols
R-HSA-202430	Translocation of ZAP-70 to Immunological synapse	20.50	2.42e-06	6.99e-04	5/14	HLA-DRB5; HLA-DRB1; HLA-DQB1; HLA-DPA1; CD3D
R-HSA-389948	PD-1 signaling	19.20	3.58e-06	7.75e-04	5/15	HLA-DRB5; HLA-DRB1; HLA-DQB1; HLA-DPA1; CD3D
R-HSA-202427	Phosphorylation of CD3 and TCR zeta chains	16.90	7.18e-06	1.05e-03	5/17	HLA-DRB5; HLA-DRB1; HLA-DQB1; HLA-DPA1; CD3D
R-HSA-202433	Generation of second messenger molecules	15.00	1.75e-06	6.99e-04	6/23	HLA-DRB5; HLA-DRB1; HLA-DQB1; HLA-DPA1; CD3D; EVL
R-HSA-198933	Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell	13.40	1.51e-09	1.31e-06	10/43	CD96; HLA-C; HLA-B; NCR3; CD3D; ITGB1; CLEC2D; B2M; ICAM2; LAIR1
R-HSA-877300	Interferon gamma signaling	9.14	7.99e-06	1.05e-03	7/44	HLA-C; HLA-B; HLA-DRB5; HLA-DRB1; HLA-DQB1; HLA-DPA1; B2M
R-HSA-388841	Costimulation by the CD28 family	8.62	5.29e-05	5.73e-03	6/40	HLA-DRB5; HLA-DRB1; HLA-DQB1; HLA-DPA1; CD3D; PPP2R5C
R-HSA-913531	Interferon Signaling	4.83	7.71e-05	7.43e-03	9/107	HLA-C; HLA-B; HLA-DRB5; HLA-DRB1; HLA-DQB1; HLA-DPA1; FLNA; IFITM2; B2M
R-HSA-1280218	Adaptive Immune System	2.84	8.48e-06	1.05e-03	20/405	TRAT1; CD96; KIF2A; HLA-C; HLA-B; NCR3; HLA-DRB5; HLA-DRB1; HLA-DQB1; HLA-DPA1; MKRN1; CD3D; ITGB1; CLEC2D; EVL; PPP2R5C; B2M; ICAM2; YWHAB; LAIR1

RASA2 : 58 significant Reactome pathways

GeneSet	description	enrichRatio	pValue	FDR	GeneRatio	geneSymbols
R-HSA-202430	Translocation of ZAP-70 to Immunological synapse	16.30	4.65e-09	7.27e-07	8/14	HLA-DRA; HLA-DRB5; HLA-DRB1; HLA-DQB1; HLA-DPA1; HLA-DPB1; CD3D; CD3G
R-HSA-389948	PD-1 signaling	15.20	9.66e-09	1.20e-06	8/15	HLA-DRA; HLA-DRB5; HLA-DRB1; HLA-DQB1; HLA-DPA1; HLA-DPB1; CD3D; CD3G
R-HSA-3928662	EPHB-mediated forward signaling	15.10	1.17e-09	2.53e-07	9/17	CDC42; ARPC5; ACTR3; ARPC2; FYN; ACTB; ARPC1B; CFL1; ACTG1
R-HSA-70263	Gluconeogenesis	14.30	1.29e-06	7.98e-05	6/12	ENO1; PGK1; PGAM1; TPI1; ALDOA; ALDOC
R-HSA-202433	Generation of second messenger molecules	13.60	6.11e-11	5.29e-08	11/23	FYB; HLA-DRA; HLA-DRB5; HLA-DRB1; HLA-DQB1; HLA-DPA1; HLA-DPB1; CD3D; CD3G; EVL; GRAP2
R-HSA-202427	Phosphorylation of CD3 and TCR zeta chains	13.40	3.44e-08	2.98e-06	8/17	HLA-DRA; HLA-DRB5; HLA-DRB1; HLA-DQB1; HLA-DPA1; HLA-DPB1; CD3D; CD3G
R-HSA-446353	Cell-extracellular matrix interactions	10.40	3.94e-04	9.22e-03	4/11	ACTB; ITGB1; ACTN1; ACTG1
R-HSA-388841	Costimulation by the CD28 family	8.55	5.03e-09	7.27e-07	12/40	CDC42; HLA-DRA; HLA-DRB5; HLA-DRB1; HLA-DQB1; HLA-DPA1; HLA-DPB1; FYN; CD3D; CD3G; PPP2R5C; GRAP2
R-HSA-2682334	EPH-Ephrin signaling	8.48	2.54e-08	2.45e-06	11/37	CDC42; ARPC5; ACTR3; ARPC2; FYN; ACTB; ARPC1B; CFL1; MYL6; ACTG1; MYL12A
R-HSA-446728	Cell junction organization	8.15	1.10e-03	1.87e-02	4/14	ACTB; ITGB1; ACTN1; ACTG1
R-HSA-5663213	RHO GTPases Activate WASPs and WAVEs	7.98	1.57e-05	6.50e-04	7/25	CDC42; ARPC5; ACTR3; ARPC2; ACTB; ARPC1B; ACTG1
R-HSA-198933	Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell	7.96	1.26e-08	1.37e-06	12/43	CD8A; CD8B; ITGA4; CD96; NCR3; JAML; CD3D; CD3G; ITGB1; CLEC2D; HCST; LAIR1
R-HSA-373755	Semaphorin interactions	7.44	1.02e-04	3.41e-03	6/23	ITGA1; FYN; CFL1; ITGB1; MYL6; MYL12A
R-HSA-2029482	Regulation of actin dynamics for phagocytic cup formation	6.94	3.29e-06	1.78e-04	9/37	CDC42; ARPC5; ACTR3; ARPC2; ACTB; ARPC1B; CFL1; CD3G; ACTG1
R-HSA-445355	Smooth Muscle Contraction	6.34	3.01e-03	4.59e-02	4/18	ITGA1; MYL6; MYL12A; TPM4
R-HSA-2029480	Fcgamma receptor (FCGR) dependent phagocytosis	6.34	2.23e-06	1.29e-04	10/45	CDC42; ARPC5; ACTR3; ARPC2; FYN; ACTB; ARPC1B; CFL1; CD3G; ACTG1
R-HSA-202733	Cell surface interactions at the vascular wall	6.11	1.02e-05	4.63e-04	9/42	CD2; CD84; CD48; ITGA4; CD74; FYN; JAML; ITGB1; MIF
R-HSA-70171	Glycolysis	6.00	3.71e-05	1.46e-03	8/38	ENO1; PGK1; PFKP; PGAM1; TPI1; PKM; ALDOA; ALDOC
R-HSA-70326	Glucose metabolism	5.43	7.96e-05	2.88e-03	8/42	ENO1; PGK1; PFKP; PGAM1; TPI1; PKM; ALDOA; ALDOC
R-HSA-1500931	Cell-Cell communication	5.35	7.09e-04	1.36e-02	6/32	FYB; FYN; ACTB; ITGB1; ACTN1; ACTG1
R-HSA-2132295	MHC class II antigen presentation	4.98	8.39e-06	4.04e-04	11/63	CAPZB; KIF2A; CD74; HLA-DRA; HLA-DRB5; HLA-DRB1; HLA-DQB1; HLA-DPA1; HLA-DPB1; CTSD; CTSC
R-HSA-72695	Formation of the ternary complex, and subsequently, the 43S complex	4.75	2.13e-04	5.60e-03	8/48	RPS18; RPS13; RPS3; RPS24; EIF3A; RPS26; RPS15A; RPS15
R-HSA-9020591	Interleukin-12 signaling	4.75	1.36e-03	2.26e-02	6/36	CDC42; CFL1; RPLP0; LCP1; P4HB; MIF
R-HSA-114608	Platelet degranulation	4.56	2.86e-04	6.88e-03	8/50	CAP1; PHACTR2; TMSB4X; CFL1; CD9; ACTN1; ALDOA; PFN1
R-HSA-877300	Interferon gamma signaling	4.54	7.19e-04	1.36e-02	7/44	GBP1; HLA-DRA; HLA-DRB5; HLA-DRB1; HLA-DQB1; HLA-DPA1; HLA-DPB1
R-HSA-76005	Response to elevated platelet cytosolic Ca2+	4.22	4.92e-04	1.07e-02	8/54	CAP1; PHACTR2; TMSB4X; CFL1; CD9; ACTN1; ALDOA; PFN1
R-HSA-1474244	Extracellular matrix organization	4.17	2.71e-03	4.23e-02	6/41	ITGA4; ITGA1; CTSD; ITGB1; ACTN1; P4HB
R-HSA-72649	Translation initiation complex formation	4.15	5.59e-04	1.15e-02	8/55	RPS18; RPS13; RPS3; RPS24; EIF3A; RPS26; RPS15A; RPS15
R-HSA-72702	Ribosomal scanning and start codon recognition	4.15	5.59e-04	1.15e-02	8/55	RPS18; RPS13; RPS3; RPS24; EIF3A; RPS26; RPS15A; RPS15
R-HSA-72662	Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S	4.07	6.34e-04	1.25e-02	8/56	RPS18; RPS13; RPS3; RPS24; EIF3A; RPS26; RPS15A; RPS15
R-HSA-447115	Interleukin-12 family signaling	4.07	3.08e-03	4.60e-02	6/42	CDC42; CFL1; RPLP0; LCP1; P4HB; MIF
R-HSA-156842	Eukaryotic Translation Elongation	3.93	3.90e-05	1.47e-03	12/87	RPL5; RPS18; EEF1D; RPS13; RPS3; RPS24; RPS26; RPLP0; RPL36AL; RPS15A; RPL23; RPS15
R-HSA-195258	RHO GTPase Effectors	3.80	6.55e-07	4.37e-05	18/135	CDC42; ARPC5; H3F3A; ACTR3; ARPC2; KIF2A; ACTB; ARPC1B; CFL1; ITGB1; MYL6; EVL; PPP2R5C; PFN1; ACTG1; MYL12A; NCF4; RAC2
R-HSA-109582	Hemostasis	3.79	6.82e-10	1.97e-07	27/203	CAPZB; CDC42; CAP1; CD2; S100A10; CD84; CD48; H3F3A; ITGA4; ITGA1; KIF2A; CD74; FYN; PHACTR2; ACTB; TMSB4X; CFL1; JAML; ITGB1; CD9; ATP2B1; ACTN1; PPP2R5C; ALDOA; PFN1; MIF; RAC2
R-HSA-156902	Peptide chain elongation	3.73	1.35e-04	4.18e-03	11/84	RPL5; RPS18; RPS13; RPS3; RPS24; RPS26; RPLP0; RPL36AL; RPS15A; RPL23; RPS15
R-HSA-192823	Viral mRNA Translation	3.73	1.35e-04	4.18e-03	11/84	RPL5; RPS18; RPS13; RPS3; RPS24; RPS26; RPLP0; RPL36AL; RPS15A; RPL23; RPS15
R-HSA-2408557	Selenocysteine synthesis	3.69	1.50e-04	4.35e-03	11/85	RPL5; RPS18; RPS13; RPS3; RPS24; RPS26; RPLP0; RPL36AL; RPS15A; RPL23; RPS15
R-HSA-72764	Eukaryotic Translation Termination	3.60	1.86e-04	5.20e-03	11/87	RPL5; RPS18; RPS13; RPS3; RPS24; RPS26; RPLP0; RPL36AL; RPS15A; RPL23; RPS15
R-HSA-72689	Formation of a pool of free 40S subunits	3.60	9.46e-05	3.28e-03	12/95	RPL5; RPS18; RPS13; RPS3; RPS24; EIF3A; RPS26; RPLP0; RPL36AL; RPS15A; RPL23; RPS15
R-HSA-975956	Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)	3.56	2.06e-04	5.59e-03	11/88	RPL5; RPS18; RPS13; RPS3; RPS24; RPS26; RPLP0; RPL36AL; RPS15A; RPL23; RPS15
R-HSA-5663220	RHO GTPases Activate Formins	3.56	1.56e-03	2.55e-02	8/64	CDC42; KIF2A; ACTB; ITGB1; EVL; PPP2R5C; PFN1; ACTG1
R-HSA-422475	Axon guidance	3.47	2.95e-10	1.28e-07	31/255	CDC42; CAP1; RPL5; ARPC5; ACTR3; CXCR4; ARPC2; SRGAP3; ITGA1; RPS18; FYN; EZR; ACTB; ARPC1B; RPS13; CFL1; RPS3; ITGB1; RPS24; RPS26; MYL6; RPLP0; RPL36AL; EVL; TCEB2; RPS15A; PFN1; RPL23; ACTG1; MYL12A; RPS15
R-HSA-2408522	Selenoamino acid metabolism	3.46	1.42e-04	4.24e-03	12/99	RPL5; DARS; RPS18; RPS13; RPS3; RPS24; RPS26; RPLP0; RPL36AL; RPS15A; RPL23; RPS15
R-HSA-194315	Signaling by Rho GTPases	3.40	4.74e-07	3.42e-05	21/176	CDC42; ARPC5; H3F3A; ACTR3; ARPC2; SRGAP3; KIF2A; TAGAP; ACTB; ARPC1B; CFL1; ITGB1; ARHGDIB; MYL6; EVL; PPP2R5C; PFN1; ACTG1; MYL12A; NCF4; RAC2
R-HSA-156827	L13a-mediated translational silencing of Ceruloplasmin expression	3.26	2.50e-04	6.38e-03	12/105	RPL5; RPS18; RPS13; RPS3; RPS24; EIF3A; RPS26; RPLP0; RPL36AL; RPS15A; RPL23; RPS15
R-HSA-72706	GTP hydrolysis and joining of the 60S ribosomal subunit	3.23	2.74e-04	6.79e-03	12/106	RPL5; RPS18; RPS13; RPS3; RPS24; EIF3A; RPS26; RPLP0; RPL36AL; RPS15A; RPL23; RPS15
R-HSA-202403	TCR signaling	3.17	5.85e-04	1.18e-02	11/99	FYB; HLA-DRA; HLA-DRB5; HLA-DRB1; HLA-DQB1; HLA-DPA1; HLA-DPB1; CD3D; CD3G; EVL; GRAP2
R-HSA-376176	Signaling by ROBO receptors	3.07	1.47e-05	6.38e-04	18/167	CDC42; CAP1; RPL5; CXCR4; SRGAP3; RPS18; RPS13; RPS3; RPS24; RPS26; RPLP0; RPL36AL; EVL; TCEB2; RPS15A; PFN1; RPL23; RPS15
R-HSA-72613	Eukaryotic Translation Initiation	3.05	4.59e-04	1.02e-02	12/112	RPL5; RPS18; RPS13; RPS3; RPS24; EIF3A; RPS26; RPLP0; RPL36AL; RPS15A; RPL23; RPS15
R-HSA-72737	Cap-dependent Translation Initiation	3.05	4.59e-04	1.02e-02	12/112	RPL5; RPS18; RPS13; RPS3; RPS24; EIF3A; RPS26; RPLP0; RPL36AL; RPS15A; RPL23; RPS15
R-HSA-927802	Nonsense-Mediated Decay (NMD)	2.99	9.66e-04	1.74e-02	11/105	RPL5; RPS18; RPS13; RPS3; RPS24; RPS26; RPLP0; RPL36AL; RPS15A; RPL23; RPS15
R-HSA-975957	Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)	2.99	9.66e-04	1.74e-02	11/105	RPL5; RPS18; RPS13; RPS3; RPS24; RPS26; RPLP0; RPL36AL; RPS15A; RPL23; RPS15
R-HSA-76002	Platelet activation, signaling and aggregation	2.96	1.05e-03	1.81e-02	11/106	CDC42; CAP1; FYN; PHACTR2; TMSB4X; CFL1; CD9; ACTN1; ALDOA; PFN1; RAC2
R-HSA-1799339	SRP-dependent cotranslational protein targeting to membrane	2.96	1.05e-03	1.81e-02	11/106	RPL5; RPS18; RPS13; RPS3; RPS24; RPS26; RPLP0; RPL36AL; RPS15A; RPL23; RPS15
R-HSA-168273	Influenza Viral RNA Transcription and Replication	2.64	2.69e-03	4.23e-02	11/119	RPL5; RPS18; RPS13; RPS3; RPS24; RPS26; RPLP0; RPL36AL; RPS15A; RPL23; RPS15
R-HSA-1266738	Developmental Biology	2.56	2.81e-07	2.21e-05	32/356	CDC42; CAP1; RPL5; ARPC5; H3F3A; ACTR3; CXCR4; ARPC2; SRGAP3; ITGA1; RPS18; FYN; EZR; ACTB; ARPC1B; RPS13; CFL1; RPS3; ITGB1; RPS24; RPS26; MYL6; RPLP0; RPL36AL; EVL; TCEB2; RPS15A; PFN1; RPL23; ACTG1; MYL12A; RPS15
R-HSA-168254	Influenza Infection	2.50	2.73e-03	4.23e-02	12/137	RPL5; RPS18; SLC25A6; RPS13; RPS3; RPS24; RPS26; RPLP0; RPL36AL; RPS15A; RPL23; RPS15
R-HSA-1280218	Adaptive Immune System	2.25	5.17e-06	2.64e-04	32/405	CAPZB; CDC42; CD8A; CD8B; ITGA4; CD96; FYB; KIF2A; CD74; NCR3; HLA-DRA; HLA-DRB5; HLA-DRB1; HLA-DQB1; HLA-DPA1; HLA-DPB1; FYN; MKRN1; CTSD; CTSC; JAML; CD3D; CD3G; ITGB1; CLEC2D; EVL; PPP2R5C; TCEB2; HCST; LAIR1; NCF4; GRAP2

TCEB2 : 44 significant Reactome pathways

GeneSet	description	enrichRatio	pValue	FDR	GeneRatio	geneSymbols
R-HSA-70263	Gluconeogenesis	9.29	2.13e-06	5.43e-05	7/12	ENO1; PGK1; PGAM1; GAPDH; TPI1; ALDOA; ALDOC
R-HSA-6803204	TP53 Regulates Transcription of Genes Involved in Cytochrome C Release	7.96	1.82e-04	4.26e-03	5/10	BNIP3L; ATM; TRIAP1; BBC3; BAX
R-HSA-8876725	Protein methylation	6.63	5.15e-04	1.14e-02	5/12	EEF1A1; HSPA8; CALM1; RPS2
R-HSA-156902	Peptide chain elongation	6.26	0.00e+00	0.00e+00	33/84	RPL5; RPS27; RPS27A; RPSA; RPL34; RPS3A; RPL37; RPS23; RPS18; EEF1A1; RPL39; RPL10; RPL30; RPL8; RPL35; RPL12; RPL7A; RPS13; RPS24; RPL6; RPLP0; RPL21; RPL36AL; RPS27L; RPLP1; RPS2; RPL27; RPS19; RPL13A; RPS9; RPL28; RPS5; RPL3
R-HSA-156842	Eukaryotic Translation Elongation	6.22	0.00e+00	0.00e+00	34/87	RPL5; RPS27; RPS27A; RPSA; RPL34; RPS3A; RPL37; RPS23; RPS18; EEF1A1; RPL39; RPL10; RPL30; EEF1D; RPL8; RPL35; RPL12; RPL7A; RPS13; RPS24; RPL6; RPLP0; RPL21; RPL36AL; RPS27L; RPLP1; RPS2; RPL27; RPS19; RPL13A; RPS9; RPL28; RPS5; RPL3
R-HSA-192823	Viral mRNA Translation	6.07	0.00e+00	0.00e+00	32/84	RPL5; RPS27; RPS27A; RPSA; RPL34; RPS3A; RPL37; RPS23; RPS18; RPL39; RPL10; RPL30; RPL8; RPL35; RPL12; RPL7A; RPS13; RPS24; RPL6; RPLP0; RPL21; RPL36AL; RPS27L; RPLP1; RPS2; RPL27; RPS19; RPL13A; RPS9; RPL28; RPS5; RPL3
R-HSA-72689	Formation of a pool of free 40S subunits	6.03	0.00e+00	0.00e+00	36/95	RPL5; RPS27; RPS27A; RPSA; RPL34; RPS3A; RPL37; RPS23; RPS18; RPL39; RPL10; RPL30; EIF3E; EIF3H; RPL8; RPL35; RPL12; RPL7A; RPS13; EIF3M; RPS24; RPL6; RPLP0; RPL21; RPL36AL; RPS27L; RPLP1; RPS2; RPL27; RPS19; RPL13A; RPS9; RPL28; RPS5; EIF3D; RPL3
R-HSA-2408557	Selenocysteine synthesis	5.99	0.00e+00	0.00e+00	32/85	RPL5; RPS27; RPS27A; RPSA; RPL34; RPS3A; RPL37; RPS23; RPS18; RPL39; RPL10; RPL30; RPL8; RPL35; RPL12; RPL7A; RPS13; RPS24; RPL6; RPLP0; RPL21; RPL36AL; RPS27L; RPLP1; RPS2; RPL27; RPS19; RPL13A; RPS9; RPL28; RPS5; RPL3
R-HSA-72695	Formation of the ternary complex, and subsequently, the 43S complex	5.97	1.63e-10	5.42e-09	18/48	RPS27; RPS27A; RPSA; RPS3A; RPS23; RPS18; EIF2S3; EIF3E; EIF3H; RPS13; EIF3M; RPS24; RPS27L; RPS2; RPS19; RPS9; RPS5; EIF3D
R-HSA-72764	Eukaryotic Translation Termination	5.86	0.00e+00	0.00e+00	32/87	RPL5; RPS27; RPS27A; RPSA; RPL34; RPS3A; RPL37; RPS23; RPS18; RPL39; RPL10; RPL30; RPL8; RPL35; RPL12; RPL7A; RPS13; RPS24; RPL6; RPLP0; RPL21; RPL36AL; RPS27L; RPLP1; RPS2; RPL27; RPS19; RPL13A; RPS9; RPL28; RPS5; RPL3
R-HSA-975956	Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)	5.79	0.00e+00	0.00e+00	32/88	RPL5; RPS27; RPS27A; RPSA; RPL34; RPS3A; RPL37; RPS23; RPS18; RPL39; RPL10; RPL30; RPL8; RPL35; RPL12; RPL7A; RPS13; RPS24; RPL6; RPLP0; RPL21; RPL36AL; RPS27L; RPLP1; RPS2; RPL27; RPS19; RPL13A; RPS9; RPL28; RPS5; RPL3
R-HSA-156827	L13a-mediated translational silencing of Ceruloplasmin expression	5.76	0.00e+00	0.00e+00	38/105	RPL5; RPS27; RPS27A; RPSA; RPL34; RPS3A; RPL37; RPS23; RPS18; EIF2S3; RPL39; RPL10; RPL30; EIF3E; EIF3H; RPL8; RPL35; RPL12; RPL7A; RPS13; EIF3M; RPS24; RPL6; RPLP0; RPL21; RPL36AL; RPS27L; RPLP1; RPS2; EIF4A1; RPL27; RPS19; RPL13A; RPS9; RPL28; RPS5; EIF3D; RPL3
R-HSA-72706	GTP hydrolysis and joining of the 60S ribosomal subunit	5.71	0.00e+00	0.00e+00	38/106	RPL5; RPS27; RPS27A; RPSA; RPL34; RPS3A; RPL37; RPS23; RPS18; EIF2S3; RPL39; RPL10; RPL30; EIF3E; EIF3H; RPL8; RPL35; RPL12; RPL7A; RPS13; EIF3M; RPS24; RPL6; RPLP0; RPL21; RPL36AL; RPS27L; RPLP1; RPS2; EIF4A1; RPL27; RPS19; RPL13A; RPS9; RPL28; RPS5; EIF3D; RPL3
R-HSA-72649	Translation initiation complex formation	5.50	2.59e-10	8.01e-09	19/55	RPS27; RPS27A; RPSA; RPS3A; RPS23; RPS18; EIF2S3; EIF3E; EIF3H; RPS13; EIF3M; RPS24; RPS27L; RPS2; EIF4A1; RPS19; RPS9; RPS5; EIF3D
R-HSA-72702	Ribosomal scanning and start codon recognition	5.50	2.59e-10	8.01e-09	19/55	RPS27; RPS27A; RPSA; RPS3A; RPS23; RPS18; EIF2S3; EIF3E; EIF3H; RPS13; EIF3M; RPS24; RPS27L; RPS2; EIF4A1; RPS19; RPS9; RPS5; EIF3D
R-HSA-72613	Eukaryotic Translation Initiation	5.40	0.00e+00	0.00e+00	38/112	RPL5; RPS27; RPS27A; RPSA; RPL34; RPS3A; RPL37; RPS23; RPS18; EIF2S3; RPL39; RPL10; RPL30; EIF3E; EIF3H; RPL8; RPL35; RPL12; RPL7A; RPS13; EIF3M; RPS24; RPL6; RPLP0; RPL21; RPL36AL; RPS27L; RPLP1; RPS2; EIF4A1; RPL27; RPS19; RPL13A; RPS9; RPL28; RPS5; EIF3D; RPL3
R-HSA-72737	Cap-dependent Translation Initiation	5.40	0.00e+00	0.00e+00	38/112	RPL5; RPS27; RPS27A; RPSA; RPL34; RPS3A; RPL37; RPS23; RPS18; EIF2S3; RPL39; RPL10; RPL30; EIF3E; EIF3H; RPL8; RPL35; RPL12; RPL7A; RPS13; EIF3M; RPS24; RPL6; RPLP0; RPL21; RPL36AL; RPS27L; RPLP1; RPS2; EIF4A1; RPL27; RPS19; RPL13A; RPS9; RPL28; RPS5; EIF3D; RPL3
R-HSA-72662	Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S	5.40	3.70e-10	1.07e-08	19/56	RPS27; RPS27A; RPSA; RPS3A; RPS23; RPS18; EIF2S3; EIF3E; EIF3H; RPS13; EIF3M; RPS24; RPS27L; RPS2; EIF4A1; RPS19; RPS9; RPS5; EIF3D
R-HSA-2408522	Selenoamino acid metabolism	5.31	1.11e-16	8.02e-15	33/99	RPL5; RPS27; RPS27A; DARS; RPSA; RPL34; RPS3A; RPL37; RPS23; RPS18; RPL39; RPL10; RPL30; RPL8; RPL35; RPL12; RPL7A; RPS13; RPS24; RPL6; RPLP0; RPL21; RPL36AL; RPS27L; RPLP1; RPS2; RPL27; RPS19; RPL13A; RPS9; RPL28; RPS5; RPL3
R-HSA-1799339	SRP-dependent cotranslational protein targeting to membrane	4.96	1.22e-15	8.14e-14	33/106	RPL5; RPS27; SSR2; RPS27A; RPSA; RPL34; RPS3A; RPL37; RPS23; RPS18; RPL39; RPL10; RPL30; RPL8; RPL35; RPL12; RPL7A; RPS13; RPS24; RPL6; RPLP0; RPL21; RPL36AL; RPS27L; RPLP1; RPS2; RPL27; RPS19; RPL13A; RPS9; RPL28; RPS5; RPL3
R-HSA-927802	Nonsense-Mediated Decay (NMD)	4.85	6.88e-15	3.98e-13	32/105	RPL5; RPS27; RPS27A; RPSA; RPL34; RPS3A; RPL37; RPS23; RPS18; RPL39; RPL10; RPL30; RPL8; RPL35; RPL12; RPL7A; RPS13; RPS24; RPL6; RPLP0; RPL21; RPL36AL; RPS27L; RPLP1; RPS2; RPL27; RPS19; RPL13A; RPS9; RPL28; RPS5; RPL3
R-HSA-975957	Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)	4.85	6.88e-15	3.98e-13	32/105	RPL5; RPS27; RPS27A; RPSA; RPL34; RPS3A; RPL37; RPS23; RPS18; RPL39; RPL10; RPL30; RPL8; RPL35; RPL12; RPL7A; RPS13; RPS24; RPL6; RPLP0; RPL21; RPL36AL; RPS27L; RPLP1; RPS2; RPL27; RPS19; RPL13A; RPS9; RPL28; RPS5; RPL3
R-HSA-168273	Influenza Viral RNA Transcription and Replication	4.42	5.44e-14	2.95e-12	33/119	RPL5; RPS27; RPS27A; RPSA; RPL34; RPS3A; RPL37; RPS23; RPS18; RPL39; RPL10; RPL30; RPL8; RPL35; RPL12; RPL7A; RPS13; RPS24; RPL6; RPLP0; RPL21; RPL36AL; RPS27L; RPLP1; RPS2; RPL27; GTF2F1; RPS19; RPL13A; RPS9; RPL28; RPS5; RPL3
R-HSA-114608	Platelet degranulation	4.14	7.45e-06	1.85e-04	13/50	OLA1; PPIA; TMSB4X; HSPA5; CFL1; CTSW; SRGN; CD9; CD63; CALM1; ALDOA; PFN1
R-HSA-168255	Influenza Life Cycle	4.10	5.36e-13	2.73e-11	33/128	RPL5; RPS27; RPS27A; RPSA; RPL34; RPS3A; RPL37; RPS23; RPS18; RPL39; RPL10; RPL30; RPL8; RPL35; RPL12; RPL7A; RPS13; RPS24; RPL6; RPLP0; RPL21; RPL36AL; RPS27L; RPLP1; RPS2; RPL27; GTF2F1; RPS19; RPL13A; RPS9; RPL28; RPS5; RPL3
R-HSA-168254	Influenza Infection	3.95	7.62e-13	3.67e-11	34/137	RPL5; RPS27; RPS27A; RPSA; RPL34; RPS3A; RPL37; RPS23; RPS18; SLC25A6; RPL39; RPL10; RPL30; RPL8; RPL35; RPL12; RPL7A; RPS13; RPS24; RPL6; RPLP0; RPL21; RPL36AL; RPS27L; RPLP1; RPS2; RPL27; GTF2F1; RPS19; RPL13A; RPS9; RPL28; RPS5; RPL3
R-HSA-76005	Response to elevated platelet cytosolic Ca2+	3.83	1.86e-05	4.47e-04	13/54	OLA1; PPIA; TMSB4X; HSPA5; CFL1; CTSW; SRGN; CD9; CD63; CALM1; ALDOA; PFN1
R-HSA-70171	Glycolysis	3.77	4.25e-04	9.70e-03	9/38	ENO1; PGK1; PFKP; PGAM1; GAPDH; TPI1; PKM; ALDOA; ALDOC
R-HSA-6791226	Major pathway of rRNA processing in the nucleolus and cytosol	3.69	2.96e-12	1.35e-10	35/151	RPL5; RPS27; RPS27A; NCL; RPSA; RPL34; RPS3A; RPL37; RPS23; RPS18; RPL39; RPL10; RPL30; RPL8; RPL35; RPL12; RPL7A; RPS13; DDX21; RPS24; RPL6; RPLP0; RPL21; RPL36AL; RPS27L; RPLP1; RPS2; NOB1; RPL27; RPS19; RPL13A; RPS9; RPL28; RPS5; RPL3
R-HSA-9010553	Regulation of expression of SLITs and ROBOs	3.57	3.40e-11	1.28e-09	33/147	RPL5; RPS27; RPS27A; RPSA; RPL34; RPS3A; RPL37; RPS23; RPS18; RPL39; RPL10; RPL30; RPL8; RPL35; RPL12; RPL7A; RPS13; RPS24; RPL6; RPLP0; RPL21; RPL36AL; RPS27L; RPLP1; RPS2; TCEB2; RPL27; RPS19; RPL13A; RPS9; RPL28; RPS5; RPL3
R-HSA-8868773	rRNA processing in the nucleus and cytosol	3.48	1.77e-11	6.98e-10	35/160	RPL5; RPS27; RPS27A; NCL; RPSA; RPL34; RPS3A; RPL37; RPS23; RPS18; RPL39; RPL10; RPL30; RPL8; RPL35; RPL12; RPL7A; RPS13; DDX21; RPS24; RPL6; RPLP0; RPL21; RPL36AL; RPS27L; RPLP1; RPS2; NOB1; RPL27; RPS19; RPL13A; RPS9; RPL28; RPS5; RPL3
R-HSA-70326	Glucose metabolism	3.41	9.33e-04	1.97e-02	9/42	ENO1; PGK1; PFKP; PGAM1; GAPDH; TPI1; PKM; ALDOA; ALDOC
R-HSA-202733	Cell surface interactions at the vascular wall	3.41	9.33e-04	1.97e-02	9/42	CD2; CD48; SELL; ITGA4; PPIA; CD44; SLC3A2; JAML; MIF
R-HSA-72312	rRNA processing	3.36	5.40e-11	1.95e-09	35/166	RPL5; RPS27; RPS27A; NCL; RPSA; RPL34; RPS3A; RPL37; RPS23; RPS18; RPL39; RPL10; RPL30; RPL8; RPL35; RPL12; RPL7A; RPS13; DDX21; RPS24; RPL6; RPLP0; RPL21; RPL36AL; RPS27L; RPLP1; RPS2; NOB1; RPL27; RPS19; RPL13A; RPS9; RPL28; RPS5; RPL3
R-HSA-376176	Signaling by ROBO receptors	3.34	6.46e-11	2.24e-09	35/167	RPL5; RPS27; RPS27A; SRGAP3; RPSA; RPL34; RPS3A; RPL37; RPS23; RPS18; RPL39; RPL10; RPL30; RPL8; RPL35; RPL12; RPL7A; RPS13; RPS24; RPL6; RPLP0; RPL21; RPL36AL; RPS27L; RPLP1; RPS2; TCEB2; PFN1; RPL27; RPS19; RPL13A; RPS9; RPL28; RPS5; RPL3
R-HSA-198933	Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell	3.33	1.12e-03	2.30e-02	9/43	SLAMF7; SELL; ITGA4; CD96; HLA-C; HLA-B; JAML; B2M; ICAM2
R-HSA-71291	Metabolism of amino acids and derivatives	2.98	3.11e-10	9.31e-09	38/203	CCBL2; RPL5; RPS27; RPS27A; DARS; RPSA; RPL34; RPS3A; RPL37; RPS23; RPS18; RPL39; RPL10; RPL30; RPL8; RPL35; RPL12; RPL7A; RPS13; SLC3A2; PCBD1; RPS24; RPL6; RPLP0; RPL21; RPL36AL; RPS27L; RPLP1; RPS2; RPL27; OAZ1; RPS19; ETHE1; RPL13A; RPS9; RPL28; RPS5; RPL3
R-HSA-422475	Axon guidance	2.87	1.15e-11	4.98e-10	46/255	RPL5; RHOC; RPS27; RPS27A; SRGAP3; RPSA; RPL34; RPS3A; RPL37; ITGA1; RPS23; CSNK2B; RPS18; EZR; ACTB; ARPC1B; RPL39; RPL10; FGFR1; RPL30; RPL8; RPL35; RPL12; RPL7A; RPS13; CFL1; ARHGEF12; HSPA8; RPS24; RPL6; RPLP0; RPL21; RPL36AL; RPS27L; RPLP1; RPS2; TCEB2; PFN1; RPL27; ACTG1; RPS19; RPL13A; RPS9; RPL28; RPS5; RPL3
R-HSA-72766	Translation	2.85	1.53e-11	6.32e-10	46/257	RPL5; MRPS21; RPS27; SSR2; RPS27A; DARS; RPSA; RPL34; RPS3A; RPL37; RPS23; RPS18; EEF1A1; EIF2S3; RPL39; RPL10; RPL30; EIF3E; EIF3H; EEF1D; RPL8; RPL35; RPL12; RPL7A; CARS; RPS13; EIF3M; RPS24; RPL6; RPLP0; RPL21; OXA1L; RPL36AL; RPS27L; RPLP1; RPS2; EIF4A1; RPL27; MRPL10; RPS19; RPL13A; RPS9; RPL28; RPS5; EIF3D; RPL3
R-HSA-109582	Hemostasis	2.43	1.98e-06	5.21e-05	31/203	CD2; S100A10; CD48; SELL; H3F3A; OLA1; ITGA4; ITGA1; KIF2A; MYB; ACTB; PPIA; TMSB4X; HSPA5; CD44; SLC3A2; CFL1; CTSW; JAML; SRGN; CD9; CD63; ATP2B1; CALM1; PPP2R5C; ANXA2; ALDOA; PFN1; MIF; RAC2
R-HSA-71387	Metabolism of carbohydrates	2.32	2.33e-03	4.50e-02	14/96	ENO1; RPS27A; TKT; PGK1; CD44; PFKP; PGAM1; GAPDH; TPI1; CALM1; PKM; ALDOA; ALDOC
R-HSA-5663205	Infectious disease	2.25	2.13e-07	5.77e-06	42/297	RPL5; RPS27; RPS27A; RPSA; RPL34; RPS3A; RPL37; RPS23; NPM1; RPS18; HMGA1; PPIA; SLC25A6; RPL39; RPL10; RPL30; RPL8; RPL35; RPL12; RPL7A; RPS13; RPS24; CD9; RPL6; RPLP0; RPL21; RPL36AL; CALM1; B2M; RPS27L; RPLP1; RPS2; TCEB2; RPL27; GTF2F1; RPS19; RPL13A; RPS9; RPL28; RPS5; RPL3
R-HSA-1266738	Developmental Biology	2.15	1.11e-07	3.10e-06	48/356	RPL5; RHOC; RPS27; H3F3A; RPS27A; SRGAP3; RPSA; RPL34; RPS3A; RPL37; ITGA1; RPS23; HIST1H4C; CSNK2B; RPS18; EZR; ACTB; ARPC1B; RPL39; RPL10; FGFR1; RPL30; RPL8; RPL35; RPL12; RPL7A; RPS13; CFL1; ARHGEF12; HSPA8; RPS24; RPL6; RPLP0; RPL21; RPL36AL; RPS27L; RPLP1; RPS2; TCEB2; PFN1; RPL27; ACTG1; RPS19; RPL13A; RPS9; RPL28; RPS5; RPL3
R-HSA-195258	RHO GTPase Effectors	2.12	1.67e-03	3.28e-02	18/135	RHOC; RPS27; H3F3A; YWHAQ; BRK1; KIF2A; HIST1H4C; ACTB; ARPC1B; CFL1; CALM1; PPP2R5C; RPS27L; PFN1; ACTG1; YWHAB; NCF4; RAC2

Summary:
Marker	CDKN1B	MEF2D	PDCD1	RASA2	TCEB2
Signif_GO_terms	151	32	9	58	44

Guided Factor Analysis on Unstimulated T Cell CROP-seq Data

-- Deviance residual transformed + normal-mixture prior

Yifan Zhou (zhouyf@uchicago.edu)

2021-09-27